-- dump date 20140619_140536 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1191523000001 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1191523000002 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1191523000003 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1191523000004 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1191523000005 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1191523000006 putative active site [active] 1191523000007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523000008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523000009 dimerization interface [polypeptide binding]; other site 1191523000010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523000011 dimer interface [polypeptide binding]; other site 1191523000012 phosphorylation site [posttranslational modification] 1191523000013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523000014 ATP binding site [chemical binding]; other site 1191523000015 Mg2+ binding site [ion binding]; other site 1191523000016 G-X-G motif; other site 1191523000017 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1191523000018 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523000019 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523000020 N-terminal plug; other site 1191523000021 ligand-binding site [chemical binding]; other site 1191523000022 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1191523000023 nucleoside/Zn binding site; other site 1191523000024 dimer interface [polypeptide binding]; other site 1191523000025 catalytic motif [active] 1191523000026 adenylate kinase; Reviewed; Region: adk; PRK00279 1191523000027 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1191523000028 AMP-binding site [chemical binding]; other site 1191523000029 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1191523000030 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1191523000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523000032 Walker A/P-loop; other site 1191523000033 ATP binding site [chemical binding]; other site 1191523000034 Q-loop/lid; other site 1191523000035 ABC transporter signature motif; other site 1191523000036 Walker B; other site 1191523000037 D-loop; other site 1191523000038 H-loop/switch region; other site 1191523000039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523000040 S-adenosylmethionine binding site [chemical binding]; other site 1191523000041 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1191523000042 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1191523000043 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1191523000044 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1191523000045 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1191523000046 RNA binding site [nucleotide binding]; other site 1191523000047 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1191523000048 multimer interface [polypeptide binding]; other site 1191523000049 Walker A motif; other site 1191523000050 ATP binding site [chemical binding]; other site 1191523000051 Walker B motif; other site 1191523000052 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1191523000053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191523000054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191523000055 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1191523000056 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1191523000057 heterodimer interface [polypeptide binding]; other site 1191523000058 active site 1191523000059 FMN binding site [chemical binding]; other site 1191523000060 homodimer interface [polypeptide binding]; other site 1191523000061 substrate binding site [chemical binding]; other site 1191523000062 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1191523000063 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1191523000064 FAD binding pocket [chemical binding]; other site 1191523000065 FAD binding motif [chemical binding]; other site 1191523000066 phosphate binding motif [ion binding]; other site 1191523000067 beta-alpha-beta structure motif; other site 1191523000068 NAD binding pocket [chemical binding]; other site 1191523000069 Iron coordination center [ion binding]; other site 1191523000070 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1191523000071 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1191523000072 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1191523000073 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1191523000074 Substrate binding site; other site 1191523000075 Cupin domain; Region: Cupin_2; cl17218 1191523000076 hypothetical protein; Provisional; Region: PRK02877 1191523000077 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1191523000078 transmembrane helices; other site 1191523000079 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1191523000080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523000081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523000082 putative substrate translocation pore; other site 1191523000083 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1191523000084 FAD binding domain; Region: FAD_binding_4; pfam01565 1191523000085 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1191523000086 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1191523000087 Competence protein; Region: Competence; pfam03772 1191523000088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191523000089 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1191523000090 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1191523000091 putative active site [active] 1191523000092 dimerization interface [polypeptide binding]; other site 1191523000093 putative tRNAtyr binding site [nucleotide binding]; other site 1191523000094 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1191523000095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523000096 S-adenosylmethionine binding site [chemical binding]; other site 1191523000097 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1191523000098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523000099 motif II; other site 1191523000100 L-arabinose isomerase; Provisional; Region: PRK02929 1191523000101 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1191523000102 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191523000103 trimer interface [polypeptide binding]; other site 1191523000104 putative substrate binding site [chemical binding]; other site 1191523000105 putative metal binding site [ion binding]; other site 1191523000106 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191523000107 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1191523000108 intersubunit interface [polypeptide binding]; other site 1191523000109 active site 1191523000110 Zn2+ binding site [ion binding]; other site 1191523000111 ribulokinase; Provisional; Region: PRK04123 1191523000112 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1191523000113 N- and C-terminal domain interface [polypeptide binding]; other site 1191523000114 active site 1191523000115 MgATP binding site [chemical binding]; other site 1191523000116 catalytic site [active] 1191523000117 metal binding site [ion binding]; metal-binding site 1191523000118 carbohydrate binding site [chemical binding]; other site 1191523000119 homodimer interface [polypeptide binding]; other site 1191523000120 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1191523000121 Na binding site [ion binding]; other site 1191523000122 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1191523000123 active site 1191523000124 catalytic residues [active] 1191523000125 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1191523000126 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1191523000127 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1191523000128 UbiA prenyltransferase family; Region: UbiA; pfam01040 1191523000129 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1191523000130 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1191523000131 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1191523000132 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1191523000133 Subunit I/III interface [polypeptide binding]; other site 1191523000134 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1191523000135 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1191523000136 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1191523000137 Cu(I) binding site [ion binding]; other site 1191523000138 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1191523000139 Cytochrome c; Region: Cytochrom_C; pfam00034 1191523000140 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1191523000141 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1191523000142 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1191523000143 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1191523000144 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1191523000145 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191523000146 molybdopterin cofactor binding site; other site 1191523000147 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1191523000148 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1191523000149 4Fe-4S binding domain; Region: Fer4; cl02805 1191523000150 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1191523000151 heme-binding residues [chemical binding]; other site 1191523000152 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1191523000153 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1191523000154 substrate binding pocket [chemical binding]; other site 1191523000155 chain length determination region; other site 1191523000156 substrate-Mg2+ binding site; other site 1191523000157 catalytic residues [active] 1191523000158 aspartate-rich region 1; other site 1191523000159 active site lid residues [active] 1191523000160 aspartate-rich region 2; other site 1191523000161 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1191523000162 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1191523000163 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1191523000164 dimer interface [polypeptide binding]; other site 1191523000165 active site 1191523000166 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1191523000167 folate binding site [chemical binding]; other site 1191523000168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523000169 binding surface 1191523000170 TPR motif; other site 1191523000171 TPR repeat; Region: TPR_11; pfam13414 1191523000172 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 1191523000173 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 1191523000174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523000175 active site 1191523000176 motif I; other site 1191523000177 motif II; other site 1191523000178 glycogen synthase; Provisional; Region: glgA; PRK00654 1191523000179 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1191523000180 ADP-binding pocket [chemical binding]; other site 1191523000181 homodimer interface [polypeptide binding]; other site 1191523000182 imidazolonepropionase; Validated; Region: PRK09356 1191523000183 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1191523000184 active site 1191523000185 glutamate formiminotransferase; Region: FtcD; TIGR02024 1191523000186 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 1191523000187 Formiminotransferase domain; Region: FTCD; pfam02971 1191523000188 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1191523000189 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1191523000190 Bacterial Ig-like domain; Region: Big_5; pfam13205 1191523000191 YceG-like family; Region: YceG; pfam02618 1191523000192 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1191523000193 dimerization interface [polypeptide binding]; other site 1191523000194 UGMP family protein; Validated; Region: PRK09604 1191523000195 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1191523000196 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1191523000197 Proline dehydrogenase; Region: Pro_dh; cl03282 1191523000198 dephospho-CoA kinase; Region: TIGR00152 1191523000199 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1191523000200 CoA-binding site [chemical binding]; other site 1191523000201 phosphodiesterase; Provisional; Region: PRK12704 1191523000202 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 1191523000203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523000204 Zn2+ binding site [ion binding]; other site 1191523000205 Mg2+ binding site [ion binding]; other site 1191523000206 Cell division protein ZapA; Region: ZapA; pfam05164 1191523000207 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1191523000208 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1191523000209 putative tRNA-binding site [nucleotide binding]; other site 1191523000210 B3/4 domain; Region: B3_4; pfam03483 1191523000211 tRNA synthetase B5 domain; Region: B5; smart00874 1191523000212 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1191523000213 dimer interface [polypeptide binding]; other site 1191523000214 motif 1; other site 1191523000215 motif 3; other site 1191523000216 motif 2; other site 1191523000217 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1191523000218 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1191523000219 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1191523000220 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1191523000221 dimer interface [polypeptide binding]; other site 1191523000222 motif 1; other site 1191523000223 active site 1191523000224 motif 2; other site 1191523000225 motif 3; other site 1191523000226 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1191523000227 23S rRNA binding site [nucleotide binding]; other site 1191523000228 L21 binding site [polypeptide binding]; other site 1191523000229 L13 binding site [polypeptide binding]; other site 1191523000230 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1191523000231 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1191523000232 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1191523000233 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1191523000234 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1191523000235 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1191523000236 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1191523000237 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1191523000238 active site 1191523000239 dimer interface [polypeptide binding]; other site 1191523000240 motif 1; other site 1191523000241 motif 2; other site 1191523000242 motif 3; other site 1191523000243 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1191523000244 anticodon binding site; other site 1191523000245 FOG: PKD repeat [General function prediction only]; Region: COG3291 1191523000246 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1191523000247 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191523000248 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1191523000249 L-rhamnose isomerase; Provisional; Region: PRK01076 1191523000250 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1191523000251 rhamnose-proton symporter; Provisional; Region: PRK13499 1191523000252 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1191523000253 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1191523000254 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191523000255 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1191523000256 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191523000257 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000258 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000259 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523000260 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523000261 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523000262 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000263 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1191523000264 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1191523000265 active site 1191523000266 catalytic site [active] 1191523000267 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1191523000268 metal binding site [ion binding]; metal-binding site 1191523000269 active site 1191523000270 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1191523000271 Ca binding site [ion binding]; other site 1191523000272 Ca binding site (active) [ion binding]; other site 1191523000273 ligand binding site [chemical binding]; other site 1191523000274 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000275 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000276 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523000277 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523000278 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523000279 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523000280 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1191523000281 N- and C-terminal domain interface [polypeptide binding]; other site 1191523000282 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1191523000283 active site 1191523000284 putative catalytic site [active] 1191523000285 metal binding site [ion binding]; metal-binding site 1191523000286 ATP binding site [chemical binding]; other site 1191523000287 carbohydrate binding site [chemical binding]; other site 1191523000288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191523000289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191523000290 DNA binding site [nucleotide binding] 1191523000291 domain linker motif; other site 1191523000292 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191523000293 dimerization interface [polypeptide binding]; other site 1191523000294 ligand binding site [chemical binding]; other site 1191523000295 iron-sulfur cluster-binding protein; Region: TIGR00273 1191523000296 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1191523000297 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1191523000298 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191523000299 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1191523000300 Acetokinase family; Region: Acetate_kinase; cl17229 1191523000301 propionate/acetate kinase; Provisional; Region: PRK12379 1191523000302 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1191523000303 intersubunit interface [polypeptide binding]; other site 1191523000304 active site 1191523000305 Zn2+ binding site [ion binding]; other site 1191523000306 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000307 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000308 central pore; other site 1191523000309 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000310 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000311 central pore; other site 1191523000312 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000313 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000314 central pore; other site 1191523000315 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191523000316 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191523000317 Hexamer interface [polypeptide binding]; other site 1191523000318 Hexagonal pore residue; other site 1191523000319 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 1191523000320 NAD(P) binding site [chemical binding]; other site 1191523000321 catalytic residues [active] 1191523000322 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191523000323 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191523000324 Hexamer interface [polypeptide binding]; other site 1191523000325 Hexagonal pore residue; other site 1191523000326 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191523000327 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191523000328 Hexamer interface [polypeptide binding]; other site 1191523000329 Hexagonal pore residue; other site 1191523000330 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1191523000331 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000332 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000333 central pore; other site 1191523000334 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 1191523000335 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191523000336 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191523000337 hypothetical protein; Provisional; Region: PRK10279 1191523000338 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1191523000339 nucleophile elbow; other site 1191523000340 Right handed beta helix region; Region: Beta_helix; pfam13229 1191523000341 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523000342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523000343 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523000344 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1191523000345 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000346 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1191523000347 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1191523000348 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1191523000349 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000350 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523000351 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523000352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523000353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523000354 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1191523000355 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1191523000356 active site 1191523000357 catalytic residues [active] 1191523000358 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000359 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191523000360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523000361 putative substrate translocation pore; other site 1191523000362 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1191523000363 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1191523000364 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1191523000365 Two component regulator propeller; Region: Reg_prop; pfam07494 1191523000366 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1191523000367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523000368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523000369 dimer interface [polypeptide binding]; other site 1191523000370 phosphorylation site [posttranslational modification] 1191523000371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523000372 ATP binding site [chemical binding]; other site 1191523000373 Mg2+ binding site [ion binding]; other site 1191523000374 G-X-G motif; other site 1191523000375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523000376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523000377 active site 1191523000378 phosphorylation site [posttranslational modification] 1191523000379 intermolecular recognition site; other site 1191523000380 dimerization interface [polypeptide binding]; other site 1191523000381 Helix-turn-helix domain; Region: HTH_18; pfam12833 1191523000382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191523000383 peptide chain release factor 1; Provisional; Region: PRK04011 1191523000384 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1191523000385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523000386 ATP binding site [chemical binding]; other site 1191523000387 putative Mg++ binding site [ion binding]; other site 1191523000388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523000389 nucleotide binding region [chemical binding]; other site 1191523000390 ATP-binding site [chemical binding]; other site 1191523000391 DNA-dependent RNA polymerase; Region: RNA_pol; pfam00940 1191523000392 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1191523000393 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1191523000394 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1191523000395 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1191523000396 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1191523000397 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1191523000398 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1191523000399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523000400 ATP binding site [chemical binding]; other site 1191523000401 putative Mg++ binding site [ion binding]; other site 1191523000402 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1191523000403 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1191523000404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523000405 putative substrate translocation pore; other site 1191523000406 transcription antitermination factor NusB; Region: nusB; TIGR01951 1191523000407 putative RNA binding site [nucleotide binding]; other site 1191523000408 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1191523000409 putative active site [active] 1191523000410 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1191523000411 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191523000412 Walker A/P-loop; other site 1191523000413 ATP binding site [chemical binding]; other site 1191523000414 Q-loop/lid; other site 1191523000415 ABC transporter signature motif; other site 1191523000416 Walker B; other site 1191523000417 D-loop; other site 1191523000418 H-loop/switch region; other site 1191523000419 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1191523000420 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523000421 Predicted integral membrane protein [Function unknown]; Region: COG5652 1191523000422 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1191523000423 putative carbohydrate kinase; Provisional; Region: PRK10565 1191523000424 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1191523000425 putative substrate binding site [chemical binding]; other site 1191523000426 putative ATP binding site [chemical binding]; other site 1191523000427 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1191523000428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523000429 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1191523000430 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1191523000431 transmembrane helices; other site 1191523000432 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1191523000433 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523000434 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1191523000435 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1191523000436 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523000437 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1191523000438 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1191523000439 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1191523000440 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1191523000441 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1191523000442 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1191523000443 putative dimer interface [polypeptide binding]; other site 1191523000444 putative anticodon binding site; other site 1191523000445 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1191523000446 homodimer interface [polypeptide binding]; other site 1191523000447 motif 1; other site 1191523000448 motif 2; other site 1191523000449 active site 1191523000450 motif 3; other site 1191523000451 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1191523000452 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1191523000453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523000454 Zn2+ binding site [ion binding]; other site 1191523000455 Mg2+ binding site [ion binding]; other site 1191523000456 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523000457 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523000458 putative active site [active] 1191523000459 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1191523000460 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1191523000461 Substrate-binding site [chemical binding]; other site 1191523000462 Substrate specificity [chemical binding]; other site 1191523000463 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1191523000464 catalytic center binding site [active] 1191523000465 ATP binding site [chemical binding]; other site 1191523000466 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1191523000467 active site 1191523000468 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1191523000469 EamA-like transporter family; Region: EamA; pfam00892 1191523000470 EamA-like transporter family; Region: EamA; pfam00892 1191523000471 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1191523000472 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1191523000473 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1191523000474 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1191523000475 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1191523000476 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1191523000477 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1191523000478 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1191523000479 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1191523000480 putative substrate binding site [chemical binding]; other site 1191523000481 nucleotide binding site [chemical binding]; other site 1191523000482 nucleotide binding site [chemical binding]; other site 1191523000483 homodimer interface [polypeptide binding]; other site 1191523000484 Predicted GTPase [General function prediction only]; Region: COG2403 1191523000485 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191523000486 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1191523000487 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1191523000488 glutaminase active site [active] 1191523000489 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1191523000490 dimer interface [polypeptide binding]; other site 1191523000491 active site 1191523000492 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1191523000493 dimer interface [polypeptide binding]; other site 1191523000494 active site 1191523000495 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1191523000496 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1191523000497 SLBB domain; Region: SLBB; pfam10531 1191523000498 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1191523000499 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1191523000500 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1191523000501 putative dimer interface [polypeptide binding]; other site 1191523000502 [2Fe-2S] cluster binding site [ion binding]; other site 1191523000503 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1191523000504 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1191523000505 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1191523000506 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1191523000507 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1191523000508 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1191523000509 acetylornithine aminotransferase; Provisional; Region: PRK02627 1191523000510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523000511 inhibitor-cofactor binding pocket; inhibition site 1191523000512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523000513 catalytic residue [active] 1191523000514 acetylglutamate/acetylaminoadipate kinase; Provisional; Region: PRK14058 1191523000515 nucleotide binding site [chemical binding]; other site 1191523000516 substrate binding site [chemical binding]; other site 1191523000517 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1191523000518 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1191523000519 active site 1191523000520 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1191523000521 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191523000522 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1191523000523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523000524 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1191523000525 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1191523000526 active site 1191523000527 catalytic residues [active] 1191523000528 metal binding site [ion binding]; metal-binding site 1191523000529 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 1191523000530 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191523000531 MoxR-like ATPases [General function prediction only]; Region: COG0714 1191523000532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523000533 Walker A motif; other site 1191523000534 ATP binding site [chemical binding]; other site 1191523000535 Walker B motif; other site 1191523000536 arginine finger; other site 1191523000537 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1191523000538 SurA N-terminal domain; Region: SurA_N; pfam09312 1191523000539 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191523000540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191523000541 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 1191523000542 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1191523000543 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191523000544 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191523000545 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191523000546 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1191523000547 DNA methylase; Region: N6_N4_Mtase; pfam01555 1191523000548 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1191523000549 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1191523000550 active site 1191523000551 HIGH motif; other site 1191523000552 KMSKS motif; other site 1191523000553 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1191523000554 tRNA binding surface [nucleotide binding]; other site 1191523000555 anticodon binding site; other site 1191523000556 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1191523000557 dimer interface [polypeptide binding]; other site 1191523000558 putative tRNA-binding site [nucleotide binding]; other site 1191523000559 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1191523000560 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1191523000561 acyl-activating enzyme (AAE) consensus motif; other site 1191523000562 putative AMP binding site [chemical binding]; other site 1191523000563 putative active site [active] 1191523000564 putative CoA binding site [chemical binding]; other site 1191523000565 Predicted membrane protein [Function unknown]; Region: COG1238 1191523000566 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1191523000567 Class II fumarases; Region: Fumarase_classII; cd01362 1191523000568 active site 1191523000569 tetramer interface [polypeptide binding]; other site 1191523000570 NlpC/P60 family; Region: NLPC_P60; pfam00877 1191523000571 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1191523000572 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1191523000573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523000574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1191523000575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523000576 DNA binding residues [nucleotide binding] 1191523000577 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000578 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000579 central pore; other site 1191523000580 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523000581 central pore; other site 1191523000582 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523000583 PIN domain; Region: PIN; pfam01850 1191523000584 phosphopentomutase; Provisional; Region: PRK05362 1191523000585 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1191523000586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523000587 GAF domain; Region: GAF; pfam01590 1191523000588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523000589 GAF domain; Region: GAF; pfam01590 1191523000590 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191523000591 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191523000592 metal binding site [ion binding]; metal-binding site 1191523000593 active site 1191523000594 I-site; other site 1191523000595 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1191523000596 G1 box; other site 1191523000597 GTP/Mg2+ binding site [chemical binding]; other site 1191523000598 Switch I region; other site 1191523000599 G2 box; other site 1191523000600 G3 box; other site 1191523000601 Switch II region; other site 1191523000602 G4 box; other site 1191523000603 G5 box; other site 1191523000604 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1191523000605 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1191523000606 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1191523000607 alphaNTD homodimer interface [polypeptide binding]; other site 1191523000608 alphaNTD - beta interaction site [polypeptide binding]; other site 1191523000609 alphaNTD - beta' interaction site [polypeptide binding]; other site 1191523000610 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1191523000611 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1191523000612 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1191523000613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191523000614 RNA binding surface [nucleotide binding]; other site 1191523000615 30S ribosomal protein S11; Validated; Region: PRK05309 1191523000616 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1191523000617 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1191523000618 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1191523000619 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1191523000620 rRNA binding site [nucleotide binding]; other site 1191523000621 predicted 30S ribosome binding site; other site 1191523000622 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1191523000623 active site 1191523000624 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1191523000625 SecY translocase; Region: SecY; pfam00344 1191523000626 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1191523000627 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1191523000628 23S rRNA binding site [nucleotide binding]; other site 1191523000629 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1191523000630 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1191523000631 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1191523000632 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1191523000633 5S rRNA interface [nucleotide binding]; other site 1191523000634 23S rRNA interface [nucleotide binding]; other site 1191523000635 L5 interface [polypeptide binding]; other site 1191523000636 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1191523000637 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1191523000638 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1191523000639 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1191523000640 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1191523000641 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1191523000642 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1191523000643 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1191523000644 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1191523000645 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1191523000646 RNA binding site [nucleotide binding]; other site 1191523000647 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1191523000648 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1191523000649 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1191523000650 putative translocon interaction site; other site 1191523000651 23S rRNA interface [nucleotide binding]; other site 1191523000652 signal recognition particle (SRP54) interaction site; other site 1191523000653 L23 interface [polypeptide binding]; other site 1191523000654 trigger factor interaction site; other site 1191523000655 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1191523000656 23S rRNA interface [nucleotide binding]; other site 1191523000657 5S rRNA interface [nucleotide binding]; other site 1191523000658 putative antibiotic binding site [chemical binding]; other site 1191523000659 L25 interface [polypeptide binding]; other site 1191523000660 L27 interface [polypeptide binding]; other site 1191523000661 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1191523000662 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1191523000663 G-X-X-G motif; other site 1191523000664 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1191523000665 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1191523000666 putative translocon binding site; other site 1191523000667 protein-rRNA interface [nucleotide binding]; other site 1191523000668 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1191523000669 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1191523000670 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1191523000671 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1191523000672 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1191523000673 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1191523000674 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1191523000675 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1191523000676 elongation factor Tu; Reviewed; Region: PRK00049 1191523000677 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1191523000678 G1 box; other site 1191523000679 GEF interaction site [polypeptide binding]; other site 1191523000680 GTP/Mg2+ binding site [chemical binding]; other site 1191523000681 Switch I region; other site 1191523000682 G2 box; other site 1191523000683 G3 box; other site 1191523000684 Switch II region; other site 1191523000685 G4 box; other site 1191523000686 G5 box; other site 1191523000687 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1191523000688 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1191523000689 Antibiotic Binding Site [chemical binding]; other site 1191523000690 elongation factor G; Reviewed; Region: PRK00007 1191523000691 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1191523000692 G1 box; other site 1191523000693 putative GEF interaction site [polypeptide binding]; other site 1191523000694 GTP/Mg2+ binding site [chemical binding]; other site 1191523000695 Switch I region; other site 1191523000696 G2 box; other site 1191523000697 G3 box; other site 1191523000698 Switch II region; other site 1191523000699 G4 box; other site 1191523000700 G5 box; other site 1191523000701 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1191523000702 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1191523000703 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1191523000704 30S ribosomal protein S7; Validated; Region: PRK05302 1191523000705 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1191523000706 S17 interaction site [polypeptide binding]; other site 1191523000707 16S rRNA interaction site [nucleotide binding]; other site 1191523000708 streptomycin interaction site [chemical binding]; other site 1191523000709 23S rRNA interaction site [nucleotide binding]; other site 1191523000710 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1191523000711 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1191523000712 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1191523000713 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1191523000714 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1191523000715 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1191523000716 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1191523000717 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1191523000718 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1191523000719 DNA binding site [nucleotide binding] 1191523000720 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1191523000721 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 1191523000722 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1191523000723 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1191523000724 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1191523000725 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1191523000726 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1191523000727 RPB3 interaction site [polypeptide binding]; other site 1191523000728 RPB1 interaction site [polypeptide binding]; other site 1191523000729 RPB11 interaction site [polypeptide binding]; other site 1191523000730 RPB10 interaction site [polypeptide binding]; other site 1191523000731 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1191523000732 L11 interface [polypeptide binding]; other site 1191523000733 putative EF-Tu interaction site [polypeptide binding]; other site 1191523000734 putative EF-G interaction site [polypeptide binding]; other site 1191523000735 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1191523000736 23S rRNA interface [nucleotide binding]; other site 1191523000737 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1191523000738 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1191523000739 mRNA/rRNA interface [nucleotide binding]; other site 1191523000740 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1191523000741 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1191523000742 23S rRNA interface [nucleotide binding]; other site 1191523000743 L7/L12 interface [polypeptide binding]; other site 1191523000744 putative thiostrepton binding site; other site 1191523000745 L25 interface [polypeptide binding]; other site 1191523000746 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1191523000747 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1191523000748 putative homodimer interface [polypeptide binding]; other site 1191523000749 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1191523000750 heterodimer interface [polypeptide binding]; other site 1191523000751 homodimer interface [polypeptide binding]; other site 1191523000752 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1191523000753 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1191523000754 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1191523000755 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1191523000756 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1191523000757 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1191523000758 active site 1191523000759 catalytic residues [active] 1191523000760 metal binding site [ion binding]; metal-binding site 1191523000761 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1191523000762 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1191523000763 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1191523000764 substrate binding site [chemical binding]; other site 1191523000765 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1191523000766 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1191523000767 substrate binding site [chemical binding]; other site 1191523000768 ligand binding site [chemical binding]; other site 1191523000769 2-isopropylmalate synthase; Validated; Region: PRK00915 1191523000770 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1191523000771 active site 1191523000772 catalytic residues [active] 1191523000773 metal binding site [ion binding]; metal-binding site 1191523000774 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1191523000775 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1191523000776 tartrate dehydrogenase; Region: TTC; TIGR02089 1191523000777 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1191523000778 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1191523000779 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1191523000780 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1191523000781 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1191523000782 putative valine binding site [chemical binding]; other site 1191523000783 dimer interface [polypeptide binding]; other site 1191523000784 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1191523000785 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1191523000786 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191523000787 PYR/PP interface [polypeptide binding]; other site 1191523000788 dimer interface [polypeptide binding]; other site 1191523000789 TPP binding site [chemical binding]; other site 1191523000790 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191523000791 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1191523000792 TPP-binding site [chemical binding]; other site 1191523000793 dimer interface [polypeptide binding]; other site 1191523000794 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1191523000795 homoserine dehydrogenase; Provisional; Region: PRK06270 1191523000796 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1191523000797 NAD(P) binding pocket [chemical binding]; other site 1191523000798 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1191523000799 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1191523000800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523000801 dimerization interface [polypeptide binding]; other site 1191523000802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1191523000803 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1191523000804 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1191523000805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1191523000806 dimer interface [polypeptide binding]; other site 1191523000807 putative CheW interface [polypeptide binding]; other site 1191523000808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523000809 active site 1191523000810 phosphorylation site [posttranslational modification] 1191523000811 intermolecular recognition site; other site 1191523000812 PAS domain S-box; Region: sensory_box; TIGR00229 1191523000813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000814 putative active site [active] 1191523000815 heme pocket [chemical binding]; other site 1191523000816 PAS domain S-box; Region: sensory_box; TIGR00229 1191523000817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000818 putative active site [active] 1191523000819 heme pocket [chemical binding]; other site 1191523000820 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523000821 GAF domain; Region: GAF; pfam01590 1191523000822 PAS domain; Region: PAS; smart00091 1191523000823 PAS fold; Region: PAS_4; pfam08448 1191523000824 PAS domain S-box; Region: sensory_box; TIGR00229 1191523000825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000826 putative active site [active] 1191523000827 heme pocket [chemical binding]; other site 1191523000828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523000829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523000830 dimer interface [polypeptide binding]; other site 1191523000831 phosphorylation site [posttranslational modification] 1191523000832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523000833 ATP binding site [chemical binding]; other site 1191523000834 Mg2+ binding site [ion binding]; other site 1191523000835 G-X-G motif; other site 1191523000836 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523000837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523000838 active site 1191523000839 phosphorylation site [posttranslational modification] 1191523000840 intermolecular recognition site; other site 1191523000841 dimerization interface [polypeptide binding]; other site 1191523000842 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191523000843 PAS domain S-box; Region: sensory_box; TIGR00229 1191523000844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000845 putative active site [active] 1191523000846 heme pocket [chemical binding]; other site 1191523000847 PAS domain; Region: PAS; smart00091 1191523000848 PAS fold; Region: PAS_4; pfam08448 1191523000849 putative active site [active] 1191523000850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000851 PAS fold; Region: PAS_3; pfam08447 1191523000852 putative active site [active] 1191523000853 heme pocket [chemical binding]; other site 1191523000854 PAS fold; Region: PAS_4; pfam08448 1191523000855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000856 putative active site [active] 1191523000857 heme pocket [chemical binding]; other site 1191523000858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523000859 PAS fold; Region: PAS_3; pfam08447 1191523000860 putative active site [active] 1191523000861 heme pocket [chemical binding]; other site 1191523000862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523000863 dimer interface [polypeptide binding]; other site 1191523000864 phosphorylation site [posttranslational modification] 1191523000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523000866 ATP binding site [chemical binding]; other site 1191523000867 Mg2+ binding site [ion binding]; other site 1191523000868 G-X-G motif; other site 1191523000869 hypothetical protein; Provisional; Region: PRK11770 1191523000870 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1191523000871 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1191523000872 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1191523000873 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1191523000874 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1191523000875 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1191523000876 hypothetical protein; Provisional; Region: PRK08201 1191523000877 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1191523000878 metal binding site [ion binding]; metal-binding site 1191523000879 putative dimer interface [polypeptide binding]; other site 1191523000880 Predicted permeases [General function prediction only]; Region: COG0795 1191523000881 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1191523000882 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1191523000883 Predicted permeases [General function prediction only]; Region: COG0795 1191523000884 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1191523000885 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1191523000886 CHASE2 domain; Region: CHASE2; pfam05226 1191523000887 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1191523000888 cyclase homology domain; Region: CHD; cd07302 1191523000889 nucleotidyl binding site; other site 1191523000890 metal binding site [ion binding]; metal-binding site 1191523000891 dimer interface [polypeptide binding]; other site 1191523000892 FecR protein; Region: FecR; pfam04773 1191523000893 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1191523000894 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523000895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523000896 TPR motif; other site 1191523000897 binding surface 1191523000898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523000899 binding surface 1191523000900 TPR repeat; Region: TPR_11; pfam13414 1191523000901 TPR motif; other site 1191523000902 TPR repeat; Region: TPR_11; pfam13414 1191523000903 TPR repeat; Region: TPR_11; pfam13414 1191523000904 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1191523000905 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1191523000906 active site 1191523000907 purine riboside binding site [chemical binding]; other site 1191523000908 urocanate hydratase; Provisional; Region: PRK05414 1191523000909 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1191523000910 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1191523000911 ligand binding site [chemical binding]; other site 1191523000912 NAD binding site [chemical binding]; other site 1191523000913 dimerization interface [polypeptide binding]; other site 1191523000914 catalytic site [active] 1191523000915 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1191523000916 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1191523000917 RimM N-terminal domain; Region: RimM; pfam01782 1191523000918 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1191523000919 KH domain; Region: KH_4; pfam13083 1191523000920 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1191523000921 signal recognition particle protein; Provisional; Region: PRK10867 1191523000922 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1191523000923 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1191523000924 P loop; other site 1191523000925 GTP binding site [chemical binding]; other site 1191523000926 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1191523000927 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1191523000928 core domain interface [polypeptide binding]; other site 1191523000929 delta subunit interface [polypeptide binding]; other site 1191523000930 epsilon subunit interface [polypeptide binding]; other site 1191523000931 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1191523000932 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1191523000933 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1191523000934 beta subunit interaction interface [polypeptide binding]; other site 1191523000935 Walker A motif; other site 1191523000936 ATP binding site [chemical binding]; other site 1191523000937 Walker B motif; other site 1191523000938 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1191523000939 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1191523000940 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1191523000941 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1191523000942 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1191523000943 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1191523000944 F0F1 ATP synthase subunit A; Provisional; Region: PRK13419 1191523000945 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1191523000946 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1191523000947 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1191523000948 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1191523000949 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1191523000950 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191523000951 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523000952 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523000953 putative active site [active] 1191523000954 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1191523000955 putative acyl-acceptor binding pocket; other site 1191523000956 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523000957 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523000958 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523000959 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523000960 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523000961 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523000962 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191523000963 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523000964 catalytic residues [active] 1191523000965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191523000966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1191523000967 active site 1191523000968 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1191523000969 classical (c) SDRs; Region: SDR_c; cd05233 1191523000970 NAD(P) binding site [chemical binding]; other site 1191523000971 active site 1191523000972 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1191523000973 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1191523000974 active site 1191523000975 PHP Thumb interface [polypeptide binding]; other site 1191523000976 metal binding site [ion binding]; metal-binding site 1191523000977 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1191523000978 generic binding surface II; other site 1191523000979 generic binding surface I; other site 1191523000980 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1191523000981 trimer interface [polypeptide binding]; other site 1191523000982 active site 1191523000983 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1191523000984 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1191523000985 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1191523000986 active site 1191523000987 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1191523000988 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1191523000989 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1191523000990 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1191523000991 Probable Catalytic site; other site 1191523000992 metal-binding site 1191523000993 CoA-binding domain; Region: CoA_binding_3; pfam13727 1191523000994 Bacterial sugar transferase; Region: Bac_transf; cl00939 1191523000995 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1191523000996 Ligand binding site; other site 1191523000997 Putative Catalytic site; other site 1191523000998 DXD motif; other site 1191523000999 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1191523001000 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1191523001001 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1191523001002 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1191523001003 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1191523001004 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191523001005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523001006 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1191523001007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523001008 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1191523001009 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1191523001010 Chain length determinant protein; Region: Wzz; cl15801 1191523001011 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1191523001012 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1191523001013 SLBB domain; Region: SLBB; pfam10531 1191523001014 SLBB domain; Region: SLBB; pfam10531 1191523001015 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523001016 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191523001017 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1191523001018 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1191523001019 NAD binding site [chemical binding]; other site 1191523001020 substrate binding site [chemical binding]; other site 1191523001021 homodimer interface [polypeptide binding]; other site 1191523001022 active site 1191523001023 cell division protein FtsZ; Region: ftsZ; TIGR00065 1191523001024 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1191523001025 nucleotide binding site [chemical binding]; other site 1191523001026 SulA interaction site; other site 1191523001027 cell division protein FtsA; Region: ftsA; TIGR01174 1191523001028 Cell division protein FtsA; Region: FtsA; smart00842 1191523001029 Cell division protein FtsA; Region: FtsA; pfam14450 1191523001030 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1191523001031 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1191523001032 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1191523001033 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191523001034 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191523001035 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191523001036 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1191523001037 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1191523001038 active site 1191523001039 homodimer interface [polypeptide binding]; other site 1191523001040 cell division protein FtsW; Region: ftsW; TIGR02614 1191523001041 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191523001042 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191523001043 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1191523001044 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1191523001045 Mg++ binding site [ion binding]; other site 1191523001046 putative catalytic motif [active] 1191523001047 putative substrate binding site [chemical binding]; other site 1191523001048 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1191523001049 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191523001050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191523001051 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1191523001052 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191523001053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191523001054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191523001055 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1191523001056 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191523001057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191523001058 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1191523001059 MraW methylase family; Region: Methyltransf_5; cl17771 1191523001060 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1191523001061 cell division protein MraZ; Reviewed; Region: PRK00326 1191523001062 MraZ protein; Region: MraZ; pfam02381 1191523001063 MraZ protein; Region: MraZ; pfam02381 1191523001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001065 binding surface 1191523001066 TPR motif; other site 1191523001067 TPR repeat; Region: TPR_11; pfam13414 1191523001068 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191523001069 IHF dimer interface [polypeptide binding]; other site 1191523001070 IHF - DNA interface [nucleotide binding]; other site 1191523001071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191523001072 metal-binding site [ion binding] 1191523001073 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1191523001074 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191523001075 metal-binding site [ion binding] 1191523001076 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191523001077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523001078 motif II; other site 1191523001079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523001080 putative substrate translocation pore; other site 1191523001081 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1191523001082 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1191523001083 active site 1191523001084 metal binding site [ion binding]; metal-binding site 1191523001085 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1191523001086 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1191523001087 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1191523001088 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1191523001089 Family description; Region: UvrD_C_2; pfam13538 1191523001090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523001091 dimerization interface [polypeptide binding]; other site 1191523001092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001093 dimer interface [polypeptide binding]; other site 1191523001094 phosphorylation site [posttranslational modification] 1191523001095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001096 ATP binding site [chemical binding]; other site 1191523001097 Mg2+ binding site [ion binding]; other site 1191523001098 G-X-G motif; other site 1191523001099 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1191523001100 dihydroorotase; Validated; Region: pyrC; PRK09357 1191523001101 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1191523001102 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1191523001103 active site 1191523001104 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1191523001105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1191523001106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1191523001107 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1191523001108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523001109 active site 1191523001110 Rrf2 family protein; Region: rrf2_super; TIGR00738 1191523001111 Transcriptional regulator; Region: Rrf2; pfam02082 1191523001112 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 1191523001113 Domain of unknown function DUF59; Region: DUF59; cl00941 1191523001114 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191523001115 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1191523001116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523001117 catalytic residue [active] 1191523001118 FeS assembly protein SufD; Region: sufD; TIGR01981 1191523001119 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1191523001120 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1191523001121 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1191523001122 Walker A/P-loop; other site 1191523001123 ATP binding site [chemical binding]; other site 1191523001124 Q-loop/lid; other site 1191523001125 ABC transporter signature motif; other site 1191523001126 Walker B; other site 1191523001127 D-loop; other site 1191523001128 H-loop/switch region; other site 1191523001129 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1191523001130 putative ABC transporter; Region: ycf24; CHL00085 1191523001131 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1191523001132 putative ADP-ribose binding site [chemical binding]; other site 1191523001133 putative active site [active] 1191523001134 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191523001135 EamA-like transporter family; Region: EamA; pfam00892 1191523001136 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523001137 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523001138 putative active site [active] 1191523001139 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523001140 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523001141 putative active site [active] 1191523001142 enolase; Provisional; Region: eno; PRK00077 1191523001143 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1191523001144 dimer interface [polypeptide binding]; other site 1191523001145 metal binding site [ion binding]; metal-binding site 1191523001146 substrate binding pocket [chemical binding]; other site 1191523001147 putative transposase OrfB; Reviewed; Region: PHA02517 1191523001148 HTH-like domain; Region: HTH_21; pfam13276 1191523001149 Integrase core domain; Region: rve; pfam00665 1191523001150 Integrase core domain; Region: rve_3; pfam13683 1191523001151 Transposase; Region: HTH_Tnp_1; pfam01527 1191523001152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1191523001153 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1191523001154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191523001155 sequence-specific DNA binding site [nucleotide binding]; other site 1191523001156 salt bridge; other site 1191523001157 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1191523001158 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1191523001159 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1191523001160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1191523001161 Divalent cation transporter; Region: MgtE; pfam01769 1191523001162 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1191523001163 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1191523001164 putative catalytic cysteine [active] 1191523001165 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1191523001166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001167 active site 1191523001168 phosphorylation site [posttranslational modification] 1191523001169 intermolecular recognition site; other site 1191523001170 dimerization interface [polypeptide binding]; other site 1191523001171 LytTr DNA-binding domain; Region: LytTR; smart00850 1191523001172 Histidine kinase; Region: His_kinase; pfam06580 1191523001173 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1191523001174 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1191523001175 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1191523001176 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1191523001177 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1191523001178 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1191523001179 NAD binding site [chemical binding]; other site 1191523001180 homodimer interface [polypeptide binding]; other site 1191523001181 active site 1191523001182 substrate binding site [chemical binding]; other site 1191523001183 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1191523001184 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1191523001185 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1191523001186 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1191523001187 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1191523001188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523001189 NAD(P) binding site [chemical binding]; other site 1191523001190 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191523001191 active site 1191523001192 phosphorylation site [posttranslational modification] 1191523001193 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1191523001194 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1191523001195 dimer interface [polypeptide binding]; other site 1191523001196 motif 1; other site 1191523001197 active site 1191523001198 motif 2; other site 1191523001199 motif 3; other site 1191523001200 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1191523001201 anticodon binding site; other site 1191523001202 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1191523001203 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1191523001204 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191523001205 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1191523001206 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1191523001207 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523001208 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191523001209 substrate binding site [chemical binding]; other site 1191523001210 ATP binding site [chemical binding]; other site 1191523001211 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1191523001212 NADP binding site [chemical binding]; other site 1191523001213 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1191523001214 active site 1191523001215 putative substrate binding site [chemical binding]; other site 1191523001216 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 1191523001217 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523001218 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1191523001219 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1191523001220 Walker A/P-loop; other site 1191523001221 ATP binding site [chemical binding]; other site 1191523001222 Q-loop/lid; other site 1191523001223 ABC transporter signature motif; other site 1191523001224 Walker B; other site 1191523001225 D-loop; other site 1191523001226 H-loop/switch region; other site 1191523001227 OstA-like protein; Region: OstA_2; pfam13100 1191523001228 OstA-like protein; Region: OstA; cl00844 1191523001229 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1191523001230 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1191523001231 putative active site [active] 1191523001232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1191523001233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523001234 active site 1191523001235 motif I; other site 1191523001236 motif II; other site 1191523001237 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1191523001238 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1191523001239 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1191523001240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001241 Walker A motif; other site 1191523001242 ATP binding site [chemical binding]; other site 1191523001243 Walker B motif; other site 1191523001244 arginine finger; other site 1191523001245 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1191523001246 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1191523001247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1191523001248 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1191523001249 B12 binding site [chemical binding]; other site 1191523001250 cobalt ligand [ion binding]; other site 1191523001251 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1191523001252 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1191523001253 Ligand binding site; other site 1191523001254 oligomer interface; other site 1191523001255 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1191523001256 Fibronectin type 3 domain; Region: FN3; smart00060 1191523001257 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 1191523001258 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1191523001259 metal ion-dependent adhesion site (MIDAS); other site 1191523001260 Peptidase family M48; Region: Peptidase_M48; pfam01435 1191523001261 TPR repeat; Region: TPR_11; pfam13414 1191523001262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001263 binding surface 1191523001264 TPR motif; other site 1191523001265 Oxygen tolerance; Region: BatD; pfam13584 1191523001266 TPR repeat; Region: TPR_11; pfam13414 1191523001267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001268 binding surface 1191523001269 TPR motif; other site 1191523001270 TPR repeat; Region: TPR_11; pfam13414 1191523001271 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1191523001272 metal ion-dependent adhesion site (MIDAS); other site 1191523001273 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1191523001274 metal ion-dependent adhesion site (MIDAS); other site 1191523001275 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1191523001276 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1191523001277 metal ion-dependent adhesion site (MIDAS); other site 1191523001278 MoxR-like ATPases [General function prediction only]; Region: COG0714 1191523001279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001280 Walker A motif; other site 1191523001281 ATP binding site [chemical binding]; other site 1191523001282 Walker B motif; other site 1191523001283 arginine finger; other site 1191523001284 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1191523001285 intersubunit interface [polypeptide binding]; other site 1191523001286 active site 1191523001287 Zn2+ binding site [ion binding]; other site 1191523001288 AbgT putative transporter family; Region: ABG_transport; cl17431 1191523001289 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1191523001290 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1191523001291 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1191523001292 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1191523001293 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1191523001294 TPR repeat; Region: TPR_11; pfam13414 1191523001295 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1191523001296 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1191523001297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191523001298 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1191523001299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191523001300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523001301 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1191523001302 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523001303 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1191523001304 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1191523001305 iron-sulfur cluster [ion binding]; other site 1191523001306 [2Fe-2S] cluster binding site [ion binding]; other site 1191523001307 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1191523001308 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1191523001309 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1191523001310 putative catalytic site [active] 1191523001311 putative metal binding site [ion binding]; other site 1191523001312 putative phosphate binding site [ion binding]; other site 1191523001313 4Fe-4S binding domain; Region: Fer4; cl02805 1191523001314 Repair protein; Region: Repair_PSII; pfam04536 1191523001315 LemA family; Region: LemA; pfam04011 1191523001316 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1191523001317 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1191523001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1191523001319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191523001320 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1191523001321 FAD binding site [chemical binding]; other site 1191523001322 homotetramer interface [polypeptide binding]; other site 1191523001323 substrate binding pocket [chemical binding]; other site 1191523001324 catalytic base [active] 1191523001325 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1191523001326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523001327 FeS/SAM binding site; other site 1191523001328 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523001329 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523001330 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523001331 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 1191523001332 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 1191523001333 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1191523001334 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191523001335 Divergent AAA domain; Region: AAA_4; pfam04326 1191523001336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001337 TPR motif; other site 1191523001338 binding surface 1191523001339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001340 binding surface 1191523001341 TPR motif; other site 1191523001342 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1191523001343 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191523001344 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 1191523001345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191523001346 ATP binding site [chemical binding]; other site 1191523001347 putative Mg++ binding site [ion binding]; other site 1191523001348 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1191523001349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523001350 nucleotide binding region [chemical binding]; other site 1191523001351 ATP-binding site [chemical binding]; other site 1191523001352 SEC-C motif; Region: SEC-C; pfam02810 1191523001353 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 1191523001354 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191523001355 metal binding triad; other site 1191523001356 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1191523001357 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191523001358 metal binding triad; other site 1191523001359 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1191523001360 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1191523001361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001362 Walker B motif; other site 1191523001363 arginine finger; other site 1191523001364 Peptidase family M41; Region: Peptidase_M41; pfam01434 1191523001365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523001366 active site 1191523001367 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1191523001368 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1191523001369 Ligand Binding Site [chemical binding]; other site 1191523001370 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1191523001371 Pyrimidine deaminase [Coenzyme metabolism]; Region: RibD; COG0117 1191523001372 active site 1191523001373 Zn binding site [ion binding]; other site 1191523001374 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1191523001375 RibD C-terminal domain; Region: RibD_C; cl17279 1191523001376 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1191523001377 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1191523001378 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1191523001379 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1191523001380 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523001381 putative catalytic residue [active] 1191523001382 OmpW family; Region: OmpW; cl17427 1191523001383 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1191523001384 putative active site [active] 1191523001385 putative metal binding residues [ion binding]; other site 1191523001386 signature motif; other site 1191523001387 putative triphosphate binding site [ion binding]; other site 1191523001388 dimer interface [polypeptide binding]; other site 1191523001389 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1191523001390 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1191523001391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191523001392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191523001393 DNA binding residues [nucleotide binding] 1191523001394 dimerization interface [polypeptide binding]; other site 1191523001395 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 1191523001396 putative active site [active] 1191523001397 Zn binding site [ion binding]; other site 1191523001398 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1191523001399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523001400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523001401 DNA binding residues [nucleotide binding] 1191523001402 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191523001403 Ligand Binding Site [chemical binding]; other site 1191523001404 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1191523001405 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1191523001406 Peptidase family M48; Region: Peptidase_M48; pfam01435 1191523001407 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1191523001408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191523001409 ABC-ATPase subunit interface; other site 1191523001410 dimer interface [polypeptide binding]; other site 1191523001411 putative PBP binding regions; other site 1191523001412 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1191523001413 GTP1/OBG; Region: GTP1_OBG; pfam01018 1191523001414 Obg GTPase; Region: Obg; cd01898 1191523001415 G1 box; other site 1191523001416 GTP/Mg2+ binding site [chemical binding]; other site 1191523001417 Switch I region; other site 1191523001418 G2 box; other site 1191523001419 G3 box; other site 1191523001420 Switch II region; other site 1191523001421 G4 box; other site 1191523001422 G5 box; other site 1191523001423 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1191523001424 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1191523001425 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523001426 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1191523001427 L-aspartate oxidase; Provisional; Region: PRK06175 1191523001428 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1191523001429 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1191523001430 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1191523001431 putative Iron-sulfur protein interface [polypeptide binding]; other site 1191523001432 proximal heme binding site [chemical binding]; other site 1191523001433 distal heme binding site [chemical binding]; other site 1191523001434 putative dimer interface [polypeptide binding]; other site 1191523001435 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1191523001436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523001437 N-terminal plug; other site 1191523001438 ligand-binding site [chemical binding]; other site 1191523001439 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1191523001440 pseudouridine synthase; Region: TIGR00093 1191523001441 active site 1191523001442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523001443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001444 dimer interface [polypeptide binding]; other site 1191523001445 phosphorylation site [posttranslational modification] 1191523001446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001447 ATP binding site [chemical binding]; other site 1191523001448 Mg2+ binding site [ion binding]; other site 1191523001449 G-X-G motif; other site 1191523001450 peroxiredoxin; Provisional; Region: PRK13189 1191523001451 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1191523001452 dimer interface [polypeptide binding]; other site 1191523001453 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1191523001454 catalytic triad [active] 1191523001455 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1191523001456 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1191523001457 dimerization interface [polypeptide binding]; other site 1191523001458 DPS ferroxidase diiron center [ion binding]; other site 1191523001459 ion pore; other site 1191523001460 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1191523001461 GAF domain; Region: GAF_3; pfam13492 1191523001462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001463 Walker A motif; other site 1191523001464 ATP binding site [chemical binding]; other site 1191523001465 Walker B motif; other site 1191523001466 arginine finger; other site 1191523001467 YCII-related domain; Region: YCII; cl00999 1191523001468 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1191523001469 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1191523001470 dimer interface [polypeptide binding]; other site 1191523001471 active site 1191523001472 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1191523001473 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1191523001474 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1191523001475 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1191523001476 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191523001477 Na binding site [ion binding]; other site 1191523001478 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191523001479 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191523001480 DNA binding site [nucleotide binding] 1191523001481 domain linker motif; other site 1191523001482 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191523001483 ligand binding site [chemical binding]; other site 1191523001484 dimerization interface [polypeptide binding]; other site 1191523001485 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1191523001486 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523001488 PAS domain; Region: PAS_9; pfam13426 1191523001489 putative active site [active] 1191523001490 heme pocket [chemical binding]; other site 1191523001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001492 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191523001493 Walker A motif; other site 1191523001494 ATP binding site [chemical binding]; other site 1191523001495 Walker B motif; other site 1191523001496 arginine finger; other site 1191523001497 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523001498 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523001499 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523001500 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523001501 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191523001502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191523001503 Coenzyme A binding pocket [chemical binding]; other site 1191523001504 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1191523001505 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1191523001506 putative active site [active] 1191523001507 catalytic triad [active] 1191523001508 putative dimer interface [polypeptide binding]; other site 1191523001509 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1191523001510 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1191523001511 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1191523001512 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 1191523001513 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1191523001514 active site 1191523001515 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1191523001516 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523001517 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1191523001518 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1191523001519 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1191523001520 protein binding site [polypeptide binding]; other site 1191523001521 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1191523001522 Domain interface; other site 1191523001523 Peptide binding site; other site 1191523001524 Active site tetrad [active] 1191523001525 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191523001526 Protein export membrane protein; Region: SecD_SecF; cl14618 1191523001527 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191523001528 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523001529 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1191523001530 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523001531 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523001532 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1191523001533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523001534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523001535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191523001536 catalytic residues [active] 1191523001537 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1191523001538 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1191523001539 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1191523001540 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1191523001541 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523001542 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191523001543 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191523001544 active site 1191523001545 catalytic tetrad [active] 1191523001546 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523001547 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1191523001548 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523001549 N-terminal plug; other site 1191523001550 ligand-binding site [chemical binding]; other site 1191523001551 Uncharacterized conserved protein [Function unknown]; Region: COG1433 1191523001552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1191523001553 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523001554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001555 active site 1191523001556 phosphorylation site [posttranslational modification] 1191523001557 intermolecular recognition site; other site 1191523001558 dimerization interface [polypeptide binding]; other site 1191523001559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001560 Walker A motif; other site 1191523001561 ATP binding site [chemical binding]; other site 1191523001562 Walker B motif; other site 1191523001563 arginine finger; other site 1191523001564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523001565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001566 ATP binding site [chemical binding]; other site 1191523001567 Mg2+ binding site [ion binding]; other site 1191523001568 G-X-G motif; other site 1191523001569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1191523001570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1191523001571 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1191523001572 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1191523001573 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523001574 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1191523001575 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1191523001576 putative active cleft [active] 1191523001577 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1191523001578 active site 1191523001579 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191523001580 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191523001581 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1191523001582 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191523001583 Na binding site [ion binding]; other site 1191523001584 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1191523001585 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 1191523001586 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1191523001587 PAS domain; Region: PAS; smart00091 1191523001588 PAS domain S-box; Region: sensory_box; TIGR00229 1191523001589 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523001590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523001591 putative active site [active] 1191523001592 heme pocket [chemical binding]; other site 1191523001593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001594 dimer interface [polypeptide binding]; other site 1191523001595 phosphorylation site [posttranslational modification] 1191523001596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001597 ATP binding site [chemical binding]; other site 1191523001598 Mg2+ binding site [ion binding]; other site 1191523001599 G-X-G motif; other site 1191523001600 HDOD domain; Region: HDOD; pfam08668 1191523001601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1191523001602 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1191523001603 dockerin binding interface; other site 1191523001604 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1191523001605 Putative Ig domain; Region: He_PIG; pfam05345 1191523001606 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001607 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1191523001608 dockerin binding interface; other site 1191523001609 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 1191523001610 dockerin binding interface; other site 1191523001611 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1191523001612 Putative Ig domain; Region: He_PIG; pfam05345 1191523001613 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001614 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1191523001615 dockerin binding interface; other site 1191523001616 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 1191523001617 dockerin binding interface; other site 1191523001618 Putative Ig domain; Region: He_PIG; pfam05345 1191523001619 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001620 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523001621 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1191523001622 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191523001623 active site 1191523001624 dimer interface [polypeptide binding]; other site 1191523001625 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1191523001626 mce related protein; Region: MCE; pfam02470 1191523001627 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1191523001628 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1191523001629 Walker A/P-loop; other site 1191523001630 ATP binding site [chemical binding]; other site 1191523001631 Q-loop/lid; other site 1191523001632 ABC transporter signature motif; other site 1191523001633 Walker B; other site 1191523001634 D-loop; other site 1191523001635 H-loop/switch region; other site 1191523001636 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1191523001637 Permease; Region: Permease; pfam02405 1191523001638 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1191523001639 GIY-YIG motif/motif A; other site 1191523001640 putative active site [active] 1191523001641 putative metal binding site [ion binding]; other site 1191523001642 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1191523001643 RNA/DNA hybrid binding site [nucleotide binding]; other site 1191523001644 active site 1191523001645 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523001646 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523001647 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1191523001648 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1191523001649 putative substrate binding site [chemical binding]; other site 1191523001650 putative ATP binding site [chemical binding]; other site 1191523001651 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1191523001652 hypothetical protein; Reviewed; Region: PRK09588 1191523001653 hypothetical protein; Reviewed; Region: PRK12497 1191523001654 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1191523001655 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1191523001656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523001657 catalytic residue [active] 1191523001658 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001659 Transposase; Region: HTH_Tnp_1; pfam01527 1191523001660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1191523001661 putative transposase OrfB; Reviewed; Region: PHA02517 1191523001662 HTH-like domain; Region: HTH_21; pfam13276 1191523001663 Integrase core domain; Region: rve; pfam00665 1191523001664 Integrase core domain; Region: rve_3; pfam13683 1191523001665 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1191523001666 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1191523001667 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1191523001668 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1191523001669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001670 active site 1191523001671 phosphorylation site [posttranslational modification] 1191523001672 intermolecular recognition site; other site 1191523001673 dimerization interface [polypeptide binding]; other site 1191523001674 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1191523001675 NMT1-like family; Region: NMT1_2; pfam13379 1191523001676 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1191523001677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523001678 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1191523001679 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 1191523001680 active site 1191523001681 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1191523001682 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1191523001683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523001684 active site 1191523001685 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191523001686 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1191523001687 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1191523001688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523001689 FeS/SAM binding site; other site 1191523001690 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1191523001691 active site 1191523001692 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1191523001693 NAD-dependent deacetylase; Provisional; Region: PRK00481 1191523001694 NAD+ binding site [chemical binding]; other site 1191523001695 substrate binding site [chemical binding]; other site 1191523001696 Zn binding site [ion binding]; other site 1191523001697 TPR repeat; Region: TPR_11; pfam13414 1191523001698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001699 binding surface 1191523001700 TPR motif; other site 1191523001701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523001702 TPR motif; other site 1191523001703 binding surface 1191523001704 TPR repeat; Region: TPR_11; pfam13414 1191523001705 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1191523001706 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1191523001707 generic binding surface I; other site 1191523001708 generic binding surface II; other site 1191523001709 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1191523001710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523001711 Zn2+ binding site [ion binding]; other site 1191523001712 Mg2+ binding site [ion binding]; other site 1191523001713 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 1191523001714 transcriptional activator RfaH; Region: RfaH; TIGR01955 1191523001715 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1191523001716 heterodimer interface [polypeptide binding]; other site 1191523001717 homodimer interface [polypeptide binding]; other site 1191523001718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523001719 PAS fold; Region: PAS_3; pfam08447 1191523001720 putative active site [active] 1191523001721 heme pocket [chemical binding]; other site 1191523001722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523001723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001724 dimer interface [polypeptide binding]; other site 1191523001725 phosphorylation site [posttranslational modification] 1191523001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001727 ATP binding site [chemical binding]; other site 1191523001728 Mg2+ binding site [ion binding]; other site 1191523001729 G-X-G motif; other site 1191523001730 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001732 active site 1191523001733 phosphorylation site [posttranslational modification] 1191523001734 intermolecular recognition site; other site 1191523001735 dimerization interface [polypeptide binding]; other site 1191523001736 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523001737 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523001738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523001739 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1191523001740 Ca binding site [ion binding]; other site 1191523001741 Ca binding site (active) [ion binding]; other site 1191523001742 ligand binding site [chemical binding]; other site 1191523001743 Amb_all domain; Region: Amb_all; smart00656 1191523001744 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001745 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001746 beta-D-glucuronidase; Provisional; Region: PRK10150 1191523001747 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523001748 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523001749 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523001750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523001751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523001752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523001753 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191523001754 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1191523001755 Herpesvirus DNA helicase/primase complex associated protein; Region: Herpes_HEPA; cl17366 1191523001756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523001757 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1191523001758 NAD(P) binding site [chemical binding]; other site 1191523001759 active site 1191523001760 short chain dehydrogenase; Provisional; Region: PRK06197 1191523001761 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1191523001762 putative NAD(P) binding site [chemical binding]; other site 1191523001763 active site 1191523001764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191523001765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191523001766 active site 1191523001767 catalytic tetrad [active] 1191523001768 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191523001769 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1191523001770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523001771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523001772 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1191523001773 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523001774 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523001775 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1191523001776 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1191523001777 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191523001778 Heavy-metal-associated domain; Region: HMA; pfam00403 1191523001779 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1191523001780 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1191523001781 integron integrase; Region: integrase_gron; TIGR02249 1191523001782 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1191523001783 Int/Topo IB signature motif; other site 1191523001784 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523001785 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523001786 Interdomain contacts; other site 1191523001787 Cytokine receptor motif; other site 1191523001788 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1191523001789 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1191523001790 putative active site [active] 1191523001791 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001793 active site 1191523001794 phosphorylation site [posttranslational modification] 1191523001795 intermolecular recognition site; other site 1191523001796 dimerization interface [polypeptide binding]; other site 1191523001797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523001798 Walker A motif; other site 1191523001799 ATP binding site [chemical binding]; other site 1191523001800 Walker B motif; other site 1191523001801 arginine finger; other site 1191523001802 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523001803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001804 dimer interface [polypeptide binding]; other site 1191523001805 phosphorylation site [posttranslational modification] 1191523001806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001807 ATP binding site [chemical binding]; other site 1191523001808 Mg2+ binding site [ion binding]; other site 1191523001809 G-X-G motif; other site 1191523001810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001811 active site 1191523001812 phosphorylation site [posttranslational modification] 1191523001813 intermolecular recognition site; other site 1191523001814 dimerization interface [polypeptide binding]; other site 1191523001815 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523001816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001817 active site 1191523001818 phosphorylation site [posttranslational modification] 1191523001819 intermolecular recognition site; other site 1191523001820 dimerization interface [polypeptide binding]; other site 1191523001821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523001822 dimerization interface [polypeptide binding]; other site 1191523001823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523001824 GAF domain; Region: GAF_3; pfam13492 1191523001825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001826 dimer interface [polypeptide binding]; other site 1191523001827 phosphorylation site [posttranslational modification] 1191523001828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001829 ATP binding site [chemical binding]; other site 1191523001830 Mg2+ binding site [ion binding]; other site 1191523001831 G-X-G motif; other site 1191523001832 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523001833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001834 active site 1191523001835 phosphorylation site [posttranslational modification] 1191523001836 intermolecular recognition site; other site 1191523001837 dimerization interface [polypeptide binding]; other site 1191523001838 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1191523001839 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1191523001840 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1191523001841 Walker A motif; other site 1191523001842 ATP binding site [chemical binding]; other site 1191523001843 Walker B motif; other site 1191523001844 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1191523001845 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1191523001846 Walker A motif; other site 1191523001847 ATP binding site [chemical binding]; other site 1191523001848 Walker B motif; other site 1191523001849 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191523001850 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191523001851 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1191523001852 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1191523001853 dimer interface [polypeptide binding]; other site 1191523001854 anticodon binding site; other site 1191523001855 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1191523001856 homodimer interface [polypeptide binding]; other site 1191523001857 motif 1; other site 1191523001858 active site 1191523001859 motif 2; other site 1191523001860 GAD domain; Region: GAD; pfam02938 1191523001861 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1191523001862 motif 3; other site 1191523001863 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1191523001864 CoenzymeA binding site [chemical binding]; other site 1191523001865 subunit interaction site [polypeptide binding]; other site 1191523001866 PHB binding site; other site 1191523001867 H+ Antiporter protein; Region: 2A0121; TIGR00900 1191523001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523001869 putative substrate translocation pore; other site 1191523001870 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1191523001871 dimer interface [polypeptide binding]; other site 1191523001872 active site 1191523001873 Schiff base residues; other site 1191523001874 protoporphyrinogen oxidase; Region: PLN02576 1191523001875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523001876 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1191523001877 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1191523001878 active site 1191523001879 Zn binding site [ion binding]; other site 1191523001880 Ferrochelatase; Region: Ferrochelatase; pfam00762 1191523001881 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1191523001882 C-terminal domain interface [polypeptide binding]; other site 1191523001883 active site 1191523001884 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1191523001885 active site 1191523001886 N-terminal domain interface [polypeptide binding]; other site 1191523001887 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1191523001888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523001889 FeS/SAM binding site; other site 1191523001890 HemN C-terminal domain; Region: HemN_C; pfam06969 1191523001891 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1191523001892 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1191523001893 substrate binding site [chemical binding]; other site 1191523001894 active site 1191523001895 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1191523001896 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1191523001897 active site 1191523001898 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1191523001899 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1191523001900 domain interfaces; other site 1191523001901 active site 1191523001902 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1191523001903 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1191523001904 tRNA; other site 1191523001905 putative tRNA binding site [nucleotide binding]; other site 1191523001906 putative NADP binding site [chemical binding]; other site 1191523001907 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1191523001908 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1191523001909 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1191523001910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523001911 inhibitor-cofactor binding pocket; inhibition site 1191523001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523001913 catalytic residue [active] 1191523001914 Hemerythrin; Region: Hemerythrin; cd12107 1191523001915 Fe binding site [ion binding]; other site 1191523001916 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 1191523001917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523001918 FeS/SAM binding site; other site 1191523001919 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523001920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001921 active site 1191523001922 phosphorylation site [posttranslational modification] 1191523001923 intermolecular recognition site; other site 1191523001924 dimerization interface [polypeptide binding]; other site 1191523001925 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1191523001926 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1191523001927 acyl-activating enzyme (AAE) consensus motif; other site 1191523001928 putative AMP binding site [chemical binding]; other site 1191523001929 putative active site [active] 1191523001930 putative CoA binding site [chemical binding]; other site 1191523001931 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1191523001932 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523001934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523001935 active site 1191523001936 phosphorylation site [posttranslational modification] 1191523001937 intermolecular recognition site; other site 1191523001938 dimerization interface [polypeptide binding]; other site 1191523001939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191523001940 DNA binding site [nucleotide binding] 1191523001941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523001942 HAMP domain; Region: HAMP; pfam00672 1191523001943 dimerization interface [polypeptide binding]; other site 1191523001944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523001945 dimer interface [polypeptide binding]; other site 1191523001946 phosphorylation site [posttranslational modification] 1191523001947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001948 ATP binding site [chemical binding]; other site 1191523001949 Mg2+ binding site [ion binding]; other site 1191523001950 G-X-G motif; other site 1191523001951 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1191523001952 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1191523001953 CcmE; Region: CcmE; cl00994 1191523001954 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1191523001955 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523001956 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523001957 Sel1-like repeats; Region: SEL1; smart00671 1191523001958 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1191523001959 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1191523001960 Sel1-like repeats; Region: SEL1; smart00671 1191523001961 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1191523001962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523001963 ATP binding site [chemical binding]; other site 1191523001964 Mg2+ binding site [ion binding]; other site 1191523001965 G-X-G motif; other site 1191523001966 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1191523001967 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523001968 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1191523001969 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1191523001970 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523001971 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1191523001972 Predicted Fe-S protein [General function prediction only]; Region: COG2000 1191523001973 Putative Fe-S cluster; Region: FeS; cl17515 1191523001974 PAS domain; Region: PAS; smart00091 1191523001975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191523001976 catalytic loop [active] 1191523001977 iron binding site [ion binding]; other site 1191523001978 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1191523001979 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523001980 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1191523001981 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1191523001982 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1191523001983 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1191523001984 dimer interface [polypeptide binding]; other site 1191523001985 [2Fe-2S] cluster binding site [ion binding]; other site 1191523001986 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1191523001987 dimer interface [polypeptide binding]; other site 1191523001988 [2Fe-2S] cluster binding site [ion binding]; other site 1191523001989 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1191523001990 SLBB domain; Region: SLBB; pfam10531 1191523001991 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1191523001992 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523001993 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191523001994 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1191523001995 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1191523001996 putative dimer interface [polypeptide binding]; other site 1191523001997 [2Fe-2S] cluster binding site [ion binding]; other site 1191523001998 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1191523001999 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1191523002000 CoA binding domain; Region: CoA_binding; smart00881 1191523002001 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191523002002 beta-galactosidase; Region: BGL; TIGR03356 1191523002003 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1191523002004 ligand binding site; other site 1191523002005 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1191523002006 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1191523002007 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1191523002008 GIY-YIG motif/motif A; other site 1191523002009 putative active site [active] 1191523002010 putative metal binding site [ion binding]; other site 1191523002011 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 1191523002012 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191523002013 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1191523002014 dimer interface [polypeptide binding]; other site 1191523002015 substrate binding site [chemical binding]; other site 1191523002016 metal binding site [ion binding]; metal-binding site 1191523002017 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1191523002018 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1191523002019 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1191523002020 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 1191523002021 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 1191523002022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523002023 carboxyltransferase (CT) interaction site; other site 1191523002024 biotinylation site [posttranslational modification]; other site 1191523002025 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1191523002026 pullulanase, type I; Region: pulA_typeI; TIGR02104 1191523002027 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1191523002028 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1191523002029 active site 1191523002030 catalytic site [active] 1191523002031 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191523002032 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191523002033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002034 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523002035 putative active site [active] 1191523002036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002037 putative active site [active] 1191523002038 heme pocket [chemical binding]; other site 1191523002039 PAS domain S-box; Region: sensory_box; TIGR00229 1191523002040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002041 putative active site [active] 1191523002042 heme pocket [chemical binding]; other site 1191523002043 PAS fold; Region: PAS_3; pfam08447 1191523002044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002045 putative active site [active] 1191523002046 heme pocket [chemical binding]; other site 1191523002047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002049 dimer interface [polypeptide binding]; other site 1191523002050 phosphorylation site [posttranslational modification] 1191523002051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002052 ATP binding site [chemical binding]; other site 1191523002053 Mg2+ binding site [ion binding]; other site 1191523002054 G-X-G motif; other site 1191523002055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523002056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002057 active site 1191523002058 phosphorylation site [posttranslational modification] 1191523002059 intermolecular recognition site; other site 1191523002060 dimerization interface [polypeptide binding]; other site 1191523002061 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1191523002062 Peptidase family M28; Region: Peptidase_M28; pfam04389 1191523002063 metal binding site [ion binding]; metal-binding site 1191523002064 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523002065 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1191523002066 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1191523002067 FMN binding site [chemical binding]; other site 1191523002068 substrate binding site [chemical binding]; other site 1191523002069 putative catalytic residue [active] 1191523002070 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523002071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1191523002072 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1191523002073 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1191523002074 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1191523002075 RIP metalloprotease RseP; Region: TIGR00054 1191523002076 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1191523002077 active site 1191523002078 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1191523002079 protein binding site [polypeptide binding]; other site 1191523002080 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1191523002081 protein binding site [polypeptide binding]; other site 1191523002082 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1191523002083 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1191523002084 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523002085 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1191523002086 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191523002087 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1191523002088 active site 1191523002089 motif 2; other site 1191523002090 motif 3; other site 1191523002091 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1191523002092 anticodon binding site; other site 1191523002093 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1191523002094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002096 dimer interface [polypeptide binding]; other site 1191523002097 phosphorylation site [posttranslational modification] 1191523002098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002099 ATP binding site [chemical binding]; other site 1191523002100 Mg2+ binding site [ion binding]; other site 1191523002101 G-X-G motif; other site 1191523002102 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1191523002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002104 active site 1191523002105 phosphorylation site [posttranslational modification] 1191523002106 intermolecular recognition site; other site 1191523002107 dimerization interface [polypeptide binding]; other site 1191523002108 LytTr DNA-binding domain; Region: LytTR; smart00850 1191523002109 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523002110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002111 putative active site [active] 1191523002112 heme pocket [chemical binding]; other site 1191523002113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002114 putative active site [active] 1191523002115 heme pocket [chemical binding]; other site 1191523002116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002118 dimer interface [polypeptide binding]; other site 1191523002119 phosphorylation site [posttranslational modification] 1191523002120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002121 ATP binding site [chemical binding]; other site 1191523002122 Mg2+ binding site [ion binding]; other site 1191523002123 G-X-G motif; other site 1191523002124 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523002125 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1191523002126 TIGR01777 family protein; Region: yfcH 1191523002127 putative NAD(P) binding site [chemical binding]; other site 1191523002128 putative active site [active] 1191523002129 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1191523002130 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1191523002131 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1191523002132 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1191523002133 active site 1191523002134 metal binding site [ion binding]; metal-binding site 1191523002135 Cytochrome c; Region: Cytochrom_C; pfam00034 1191523002136 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191523002137 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1191523002138 intersubunit interface [polypeptide binding]; other site 1191523002139 active site 1191523002140 zinc binding site [ion binding]; other site 1191523002141 Na+ binding site [ion binding]; other site 1191523002142 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1191523002143 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1191523002144 FOG: CBS domain [General function prediction only]; Region: COG0517 1191523002145 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1191523002146 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1191523002147 proline aminopeptidase P II; Provisional; Region: PRK10879 1191523002148 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1191523002149 active site 1191523002150 EamA-like transporter family; Region: EamA; pfam00892 1191523002151 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191523002152 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191523002153 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1191523002154 Repair protein; Region: Repair_PSII; cl01535 1191523002155 Repair protein; Region: Repair_PSII; cl01535 1191523002156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191523002157 catalytic core [active] 1191523002158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191523002159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523002160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002161 binding surface 1191523002162 TPR motif; other site 1191523002163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523002164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002165 binding surface 1191523002166 TPR motif; other site 1191523002167 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523002168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523002169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002170 binding surface 1191523002171 TPR motif; other site 1191523002172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523002173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002175 dimer interface [polypeptide binding]; other site 1191523002176 phosphorylation site [posttranslational modification] 1191523002177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002178 ATP binding site [chemical binding]; other site 1191523002179 Mg2+ binding site [ion binding]; other site 1191523002180 G-X-G motif; other site 1191523002181 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191523002182 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191523002183 transketolase; Reviewed; Region: PRK05899 1191523002184 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191523002185 TPP-binding site [chemical binding]; other site 1191523002186 dimer interface [polypeptide binding]; other site 1191523002187 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191523002188 PYR/PP interface [polypeptide binding]; other site 1191523002189 dimer interface [polypeptide binding]; other site 1191523002190 TPP binding site [chemical binding]; other site 1191523002191 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191523002192 DNA polymerase IV; Reviewed; Region: PRK03103 1191523002193 Y-family of DNA polymerases; Region: PolY; cd00424 1191523002194 active site 1191523002195 DNA binding site [nucleotide binding] 1191523002196 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1191523002197 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1191523002198 putative ligand binding pocket/active site [active] 1191523002199 putative metal binding site [ion binding]; other site 1191523002200 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1191523002201 AMMECR1; Region: AMMECR1; pfam01871 1191523002202 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1191523002203 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1191523002204 substrate binding site [chemical binding]; other site 1191523002205 tetramer interface [polypeptide binding]; other site 1191523002206 catalytic residue [active] 1191523002207 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1191523002208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523002209 primosomal protein N' Region: priA; TIGR00595 1191523002210 ATP binding site [chemical binding]; other site 1191523002211 putative Mg++ binding site [ion binding]; other site 1191523002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523002213 ATP-binding site [chemical binding]; other site 1191523002214 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1191523002215 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191523002216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523002217 catalytic residues [active] 1191523002218 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1191523002219 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1191523002220 active site 1191523002221 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1191523002222 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1191523002223 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1191523002224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002225 putative active site [active] 1191523002226 heme pocket [chemical binding]; other site 1191523002227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002228 putative active site [active] 1191523002229 heme pocket [chemical binding]; other site 1191523002230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002231 dimer interface [polypeptide binding]; other site 1191523002232 phosphorylation site [posttranslational modification] 1191523002233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002234 ATP binding site [chemical binding]; other site 1191523002235 Mg2+ binding site [ion binding]; other site 1191523002236 G-X-G motif; other site 1191523002237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1191523002238 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1191523002239 active site 1191523002240 B12 binding domain; Region: B12-binding_2; pfam02607 1191523002241 B12 binding domain; Region: B12-binding; pfam02310 1191523002242 B12 binding site [chemical binding]; other site 1191523002243 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 1191523002244 Lamin Tail Domain; Region: LTD; pfam00932 1191523002245 Lamin Tail Domain; Region: LTD; pfam00932 1191523002246 Lamin Tail Domain; Region: LTD; pfam00932 1191523002247 Lamin Tail Domain; Region: LTD; pfam00932 1191523002248 Lamin Tail Domain; Region: LTD; pfam00932 1191523002249 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523002250 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523002251 Peptidase family M28; Region: Peptidase_M28; pfam04389 1191523002252 metal binding site [ion binding]; metal-binding site 1191523002253 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1191523002254 active site 1191523002255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191523002256 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1191523002257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523002258 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1191523002259 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1191523002260 active site 1191523002261 dimer interface [polypeptide binding]; other site 1191523002262 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1191523002263 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1191523002264 active site 1191523002265 FMN binding site [chemical binding]; other site 1191523002266 substrate binding site [chemical binding]; other site 1191523002267 3Fe-4S cluster binding site [ion binding]; other site 1191523002268 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1191523002269 domain interface; other site 1191523002270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523002271 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191523002272 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1191523002273 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1191523002274 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1191523002275 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1191523002276 HflX GTPase family; Region: HflX; cd01878 1191523002277 G1 box; other site 1191523002278 GTP/Mg2+ binding site [chemical binding]; other site 1191523002279 Switch I region; other site 1191523002280 G2 box; other site 1191523002281 G3 box; other site 1191523002282 Switch II region; other site 1191523002283 G4 box; other site 1191523002284 G5 box; other site 1191523002285 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1191523002286 active sites [active] 1191523002287 tetramer interface [polypeptide binding]; other site 1191523002288 EamA-like transporter family; Region: EamA; pfam00892 1191523002289 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191523002290 EamA-like transporter family; Region: EamA; pfam00892 1191523002291 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1191523002292 homodimer interface [polypeptide binding]; other site 1191523002293 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191523002294 substrate-cofactor binding pocket; other site 1191523002295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523002296 catalytic residue [active] 1191523002297 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1191523002298 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1191523002299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191523002300 MarR family; Region: MarR; pfam01047 1191523002301 MarR family; Region: MarR_2; cl17246 1191523002302 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1191523002303 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1191523002304 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1191523002305 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191523002306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523002307 catalytic residue [active] 1191523002308 PspC domain; Region: PspC; pfam04024 1191523002309 PspC domain; Region: PspC; pfam04024 1191523002310 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1191523002311 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1191523002312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523002313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523002314 DNA binding residues [nucleotide binding] 1191523002315 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1191523002316 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1191523002317 motif 1; other site 1191523002318 active site 1191523002319 motif 2; other site 1191523002320 motif 3; other site 1191523002321 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1191523002322 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1191523002323 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1191523002324 NAD(P) binding site [chemical binding]; other site 1191523002325 catalytic residues [active] 1191523002326 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1191523002327 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1191523002328 putative active site [active] 1191523002329 PhoH-like protein; Region: PhoH; pfam02562 1191523002330 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1191523002331 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523002332 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1191523002333 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1191523002334 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1191523002335 protein binding site [polypeptide binding]; other site 1191523002336 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1191523002337 Domain interface; other site 1191523002338 Peptide binding site; other site 1191523002339 Active site tetrad [active] 1191523002340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523002341 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1191523002342 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1191523002343 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1191523002344 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191523002345 ligand binding site [chemical binding]; other site 1191523002346 flexible hinge region; other site 1191523002347 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523002348 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191523002349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002351 ATP binding site [chemical binding]; other site 1191523002352 Mg2+ binding site [ion binding]; other site 1191523002353 G-X-G motif; other site 1191523002354 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191523002355 endonuclease III; Region: ENDO3c; smart00478 1191523002356 minor groove reading motif; other site 1191523002357 helix-hairpin-helix signature motif; other site 1191523002358 substrate binding pocket [chemical binding]; other site 1191523002359 active site 1191523002360 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1191523002361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523002362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523002363 DNA binding residues [nucleotide binding] 1191523002364 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1191523002365 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1191523002366 RuvA N terminal domain; Region: RuvA_N; pfam01330 1191523002367 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1191523002368 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1191523002369 active site 1191523002370 putative DNA-binding cleft [nucleotide binding]; other site 1191523002371 dimer interface [polypeptide binding]; other site 1191523002372 hypothetical protein; Validated; Region: PRK00110 1191523002373 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1191523002374 DHH family; Region: DHH; pfam01368 1191523002375 DHHA1 domain; Region: DHHA1; pfam02272 1191523002376 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1191523002377 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1191523002378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523002379 FeS/SAM binding site; other site 1191523002380 Predicted helicase [General function prediction only]; Region: COG4889 1191523002381 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1191523002382 High-affinity nickel-transport protein; Region: NicO; cl00964 1191523002383 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523002384 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1191523002385 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1191523002386 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191523002387 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191523002388 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1191523002389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191523002390 nucleotide binding site [chemical binding]; other site 1191523002391 Glucokinase; Region: Glucokinase; cl17310 1191523002392 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1191523002393 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1191523002394 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1191523002395 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1191523002396 active site 1191523002397 catalytic site [active] 1191523002398 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523002399 SusE outer membrane protein; Region: SusE; pfam14292 1191523002400 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 1191523002401 starch binding site [chemical binding]; other site 1191523002402 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 1191523002403 starch binding site [chemical binding]; other site 1191523002404 starch binding outer membrane protein SusD; Region: SusD; cd08977 1191523002405 starch binding outer membrane protein SusD; Region: SusD; cd08977 1191523002406 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523002407 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 1191523002408 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523002409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523002410 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1191523002411 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1191523002412 active site 1191523002413 homodimer interface [polypeptide binding]; other site 1191523002414 catalytic site [active] 1191523002415 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1191523002416 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1191523002417 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1191523002418 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1191523002419 trimer interface [polypeptide binding]; other site 1191523002420 active site 1191523002421 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1191523002422 catalytic site [active] 1191523002423 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1191523002424 Na binding site [ion binding]; other site 1191523002425 peptidase T; Region: peptidase-T; TIGR01882 1191523002426 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1191523002427 metal binding site [ion binding]; metal-binding site 1191523002428 dimer interface [polypeptide binding]; other site 1191523002429 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1191523002430 Cation efflux family; Region: Cation_efflux; pfam01545 1191523002431 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1191523002432 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191523002433 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1191523002434 acyl-activating enzyme (AAE) consensus motif; other site 1191523002435 putative AMP binding site [chemical binding]; other site 1191523002436 putative active site [active] 1191523002437 putative CoA binding site [chemical binding]; other site 1191523002438 carboxy-terminal protease; Provisional; Region: PRK11186 1191523002439 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1191523002440 protein binding site [polypeptide binding]; other site 1191523002441 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1191523002442 Catalytic dyad [active] 1191523002443 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1191523002444 Outer membrane efflux protein; Region: OEP; pfam02321 1191523002445 Outer membrane efflux protein; Region: OEP; pfam02321 1191523002446 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1191523002447 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523002448 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1191523002449 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1191523002450 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191523002451 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1191523002452 Double zinc ribbon; Region: DZR; pfam12773 1191523002453 Cytochrome C biogenesis protein; Region: CcmH; cl01179 1191523002454 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1191523002455 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1191523002456 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523002457 FtsX-like permease family; Region: FtsX; pfam02687 1191523002458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191523002459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191523002460 Walker A/P-loop; other site 1191523002461 ATP binding site [chemical binding]; other site 1191523002462 Q-loop/lid; other site 1191523002463 ABC transporter signature motif; other site 1191523002464 Walker B; other site 1191523002465 D-loop; other site 1191523002466 H-loop/switch region; other site 1191523002467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1191523002468 binding surface 1191523002469 TPR motif; other site 1191523002470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002471 binding surface 1191523002472 TPR motif; other site 1191523002473 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1191523002474 Predicted transcriptional regulators [Transcription]; Region: COG1695 1191523002475 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1191523002476 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191523002477 4Fe-4S binding domain; Region: Fer4; cl02805 1191523002478 DsrE/DsrF-like family; Region: DrsE; cl00672 1191523002479 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1191523002480 YHS domain; Region: YHS; pfam04945 1191523002481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191523002482 metal-binding site [ion binding] 1191523002483 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1191523002484 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191523002485 metal-binding site [ion binding] 1191523002486 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191523002487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523002488 motif II; other site 1191523002489 Short C-terminal domain; Region: SHOCT; pfam09851 1191523002490 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1191523002491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523002492 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1191523002493 Domain of unknown function DUF302; Region: DUF302; cl01364 1191523002494 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1191523002495 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1191523002496 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1191523002497 Domain of unknown function DUF77; Region: DUF77; pfam01910 1191523002498 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1191523002499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523002500 S-adenosylmethionine binding site [chemical binding]; other site 1191523002501 SpoVG; Region: SpoVG; cl00915 1191523002502 AAA domain; Region: AAA_14; pfam13173 1191523002503 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1191523002504 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1191523002505 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 1191523002506 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1191523002507 four helix bundle protein; Region: TIGR02436 1191523002508 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1191523002509 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1191523002510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191523002511 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1191523002512 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 1191523002513 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1191523002514 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1191523002515 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1191523002516 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1191523002517 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1191523002518 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1191523002519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1191523002520 Putative zinc-finger; Region: zf-HC2; pfam13490 1191523002521 YacP-like NYN domain; Region: NYN_YacP; cl01491 1191523002522 CHASE3 domain; Region: CHASE3; cl05000 1191523002523 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1191523002524 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1191523002525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523002526 dimerization interface [polypeptide binding]; other site 1191523002527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1191523002528 dimer interface [polypeptide binding]; other site 1191523002529 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1191523002530 putative CheW interface [polypeptide binding]; other site 1191523002531 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1191523002532 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1191523002533 putative CheA interaction surface; other site 1191523002534 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523002535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002536 active site 1191523002537 phosphorylation site [posttranslational modification] 1191523002538 intermolecular recognition site; other site 1191523002539 dimerization interface [polypeptide binding]; other site 1191523002540 LytTr DNA-binding domain; Region: LytTR; pfam04397 1191523002541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002543 dimer interface [polypeptide binding]; other site 1191523002544 phosphorylation site [posttranslational modification] 1191523002545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002546 ATP binding site [chemical binding]; other site 1191523002547 Mg2+ binding site [ion binding]; other site 1191523002548 G-X-G motif; other site 1191523002549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523002550 GAF domain; Region: GAF; cl17456 1191523002551 PAS domain; Region: PAS_8; pfam13188 1191523002552 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1191523002553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1191523002554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002556 ATP binding site [chemical binding]; other site 1191523002557 Mg2+ binding site [ion binding]; other site 1191523002558 G-X-G motif; other site 1191523002559 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523002560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002561 active site 1191523002562 phosphorylation site [posttranslational modification] 1191523002563 intermolecular recognition site; other site 1191523002564 dimerization interface [polypeptide binding]; other site 1191523002565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523002566 Walker A motif; other site 1191523002567 ATP binding site [chemical binding]; other site 1191523002568 Walker B motif; other site 1191523002569 arginine finger; other site 1191523002570 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1191523002571 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1191523002572 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1191523002573 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1191523002574 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1191523002575 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1191523002576 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1191523002577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191523002578 acyl-activating enzyme (AAE) consensus motif; other site 1191523002579 AMP binding site [chemical binding]; other site 1191523002580 active site 1191523002581 CoA binding site [chemical binding]; other site 1191523002582 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1191523002583 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1191523002584 active site 1191523002585 oxyanion hole [active] 1191523002586 catalytic triad [active] 1191523002587 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1191523002588 active site 1191523002589 catalytic triad [active] 1191523002590 oxyanion hole [active] 1191523002591 phosphodiesterase; Provisional; Region: PRK12704 1191523002592 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1191523002593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1191523002594 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1191523002595 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1191523002596 substrate binding site; other site 1191523002597 tetramer interface; other site 1191523002598 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1191523002599 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1191523002600 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1191523002601 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1191523002602 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1191523002603 CoA-ligase; Region: Ligase_CoA; pfam00549 1191523002604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002605 active site 1191523002606 phosphorylation site [posttranslational modification] 1191523002607 intermolecular recognition site; other site 1191523002608 dimerization interface [polypeptide binding]; other site 1191523002609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1191523002610 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523002611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002612 active site 1191523002613 phosphorylation site [posttranslational modification] 1191523002614 intermolecular recognition site; other site 1191523002615 dimerization interface [polypeptide binding]; other site 1191523002616 HDOD domain; Region: HDOD; pfam08668 1191523002617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523002618 Zn2+ binding site [ion binding]; other site 1191523002619 Mg2+ binding site [ion binding]; other site 1191523002620 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1191523002621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523002622 putative active site [active] 1191523002623 heme pocket [chemical binding]; other site 1191523002624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002625 ATP binding site [chemical binding]; other site 1191523002626 Mg2+ binding site [ion binding]; other site 1191523002627 G-X-G motif; other site 1191523002628 YceI-like domain; Region: YceI; pfam04264 1191523002629 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1191523002630 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1191523002631 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1191523002632 Walker A/P-loop; other site 1191523002633 ATP binding site [chemical binding]; other site 1191523002634 Q-loop/lid; other site 1191523002635 ABC transporter signature motif; other site 1191523002636 Walker B; other site 1191523002637 D-loop; other site 1191523002638 H-loop/switch region; other site 1191523002639 muropeptide transporter; Validated; Region: ampG; cl17669 1191523002640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523002641 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1191523002642 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 1191523002643 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1191523002644 putative deacylase active site [active] 1191523002645 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1191523002646 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523002647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523002648 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191523002649 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1191523002650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191523002651 E3 interaction surface; other site 1191523002652 lipoyl attachment site [posttranslational modification]; other site 1191523002653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191523002654 E3 interaction surface; other site 1191523002655 lipoyl attachment site [posttranslational modification]; other site 1191523002656 e3 binding domain; Region: E3_binding; pfam02817 1191523002657 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1191523002658 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1191523002659 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1191523002660 dimer interface [polypeptide binding]; other site 1191523002661 TPP-binding site [chemical binding]; other site 1191523002662 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1191523002663 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1191523002664 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1191523002665 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 1191523002666 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1191523002667 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191523002668 Active Sites [active] 1191523002669 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1191523002670 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191523002671 Active Sites [active] 1191523002672 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1191523002673 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1191523002674 CysD dimerization site [polypeptide binding]; other site 1191523002675 G1 box; other site 1191523002676 putative GEF interaction site [polypeptide binding]; other site 1191523002677 GTP/Mg2+ binding site [chemical binding]; other site 1191523002678 Switch I region; other site 1191523002679 G2 box; other site 1191523002680 G3 box; other site 1191523002681 Switch II region; other site 1191523002682 G4 box; other site 1191523002683 G5 box; other site 1191523002684 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1191523002685 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1191523002686 siroheme synthase; Provisional; Region: cysG; PRK10637 1191523002687 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1191523002688 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1191523002689 active site 1191523002690 SAM binding site [chemical binding]; other site 1191523002691 homodimer interface [polypeptide binding]; other site 1191523002692 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1191523002693 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191523002694 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191523002695 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1191523002696 CPxP motif; other site 1191523002697 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1191523002698 Transcriptional regulator; Region: Rrf2; pfam02082 1191523002699 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191523002700 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191523002701 dimer interface [polypeptide binding]; other site 1191523002702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523002703 catalytic residue [active] 1191523002704 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1191523002705 thiS-thiF/thiG interaction site; other site 1191523002706 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1191523002707 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191523002708 homodimer interface [polypeptide binding]; other site 1191523002709 substrate-cofactor binding pocket; other site 1191523002710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523002711 catalytic residue [active] 1191523002712 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1191523002713 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1191523002714 ATP binding site [chemical binding]; other site 1191523002715 substrate interface [chemical binding]; other site 1191523002716 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1191523002717 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1191523002718 CPxP motif; other site 1191523002719 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1191523002720 MPN+ (JAMM) motif; other site 1191523002721 Zinc-binding site [ion binding]; other site 1191523002722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1191523002723 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1191523002724 substrate binding pocket [chemical binding]; other site 1191523002725 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523002726 Pectinesterase; Region: Pectinesterase; pfam01095 1191523002727 putative pectinesterase; Region: PLN02432; cl01911 1191523002728 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523002729 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1191523002730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002731 active site 1191523002732 phosphorylation site [posttranslational modification] 1191523002733 intermolecular recognition site; other site 1191523002734 dimerization interface [polypeptide binding]; other site 1191523002735 LytTr DNA-binding domain; Region: LytTR; smart00850 1191523002736 Histidine kinase; Region: His_kinase; pfam06580 1191523002737 Histidine kinase; Region: His_kinase; pfam06580 1191523002738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002739 ATP binding site [chemical binding]; other site 1191523002740 Mg2+ binding site [ion binding]; other site 1191523002741 G-X-G motif; other site 1191523002742 Beta-lactamase; Region: Beta-lactamase; pfam00144 1191523002743 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1191523002744 Haem-binding domain; Region: Haem_bd; pfam14376 1191523002745 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1191523002746 active site 1191523002747 DNA binding site [nucleotide binding] 1191523002748 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523002749 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523002750 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523002751 putative active site [active] 1191523002752 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1191523002753 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1191523002754 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1191523002755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523002756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002757 dimer interface [polypeptide binding]; other site 1191523002758 phosphorylation site [posttranslational modification] 1191523002759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002760 ATP binding site [chemical binding]; other site 1191523002761 Mg2+ binding site [ion binding]; other site 1191523002762 G-X-G motif; other site 1191523002763 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1191523002764 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1191523002765 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1191523002766 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191523002767 TPR repeat; Region: TPR_11; pfam13414 1191523002768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002769 binding surface 1191523002770 TPR motif; other site 1191523002771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002772 binding surface 1191523002773 TPR motif; other site 1191523002774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002775 binding surface 1191523002776 TPR motif; other site 1191523002777 TPR repeat; Region: TPR_11; pfam13414 1191523002778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523002779 binding surface 1191523002780 TPR motif; other site 1191523002781 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523002782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1191523002783 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1191523002784 putative deacylase active site [active] 1191523002785 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523002787 active site 1191523002788 phosphorylation site [posttranslational modification] 1191523002789 intermolecular recognition site; other site 1191523002790 dimerization interface [polypeptide binding]; other site 1191523002791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523002792 Walker A motif; other site 1191523002793 ATP binding site [chemical binding]; other site 1191523002794 Walker B motif; other site 1191523002795 arginine finger; other site 1191523002796 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523002797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1191523002798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523002799 dimerization interface [polypeptide binding]; other site 1191523002800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523002801 dimer interface [polypeptide binding]; other site 1191523002802 phosphorylation site [posttranslational modification] 1191523002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523002804 ATP binding site [chemical binding]; other site 1191523002805 Mg2+ binding site [ion binding]; other site 1191523002806 G-X-G motif; other site 1191523002807 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 1191523002808 Cupin domain; Region: Cupin_2; cl17218 1191523002809 Helix-turn-helix domain; Region: HTH_18; pfam12833 1191523002810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191523002811 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1191523002812 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1191523002813 active site 1191523002814 catalytic triad [active] 1191523002815 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191523002816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523002817 Walker A motif; other site 1191523002818 ATP binding site [chemical binding]; other site 1191523002819 Walker B motif; other site 1191523002820 arginine finger; other site 1191523002821 excinuclease ABC subunit B; Provisional; Region: PRK05298 1191523002822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523002823 ATP binding site [chemical binding]; other site 1191523002824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523002825 nucleotide binding region [chemical binding]; other site 1191523002826 ATP-binding site [chemical binding]; other site 1191523002827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1191523002828 UvrB/uvrC motif; Region: UVR; pfam02151 1191523002829 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1191523002830 putative ligand binding pocket/active site [active] 1191523002831 putative metal binding site [ion binding]; other site 1191523002832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191523002833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523002834 S-adenosylmethionine binding site [chemical binding]; other site 1191523002835 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1191523002836 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1191523002837 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1191523002838 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1191523002839 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1191523002840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523002841 Walker A/P-loop; other site 1191523002842 ATP binding site [chemical binding]; other site 1191523002843 Q-loop/lid; other site 1191523002844 ABC transporter signature motif; other site 1191523002845 Walker B; other site 1191523002846 D-loop; other site 1191523002847 H-loop/switch region; other site 1191523002848 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1191523002849 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1191523002850 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1191523002851 active site 1191523002852 Zn binding site [ion binding]; other site 1191523002853 argininosuccinate lyase; Provisional; Region: PRK00855 1191523002854 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1191523002855 active sites [active] 1191523002856 tetramer interface [polypeptide binding]; other site 1191523002857 argininosuccinate synthase; Provisional; Region: PRK13820 1191523002858 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1191523002859 ANP binding site [chemical binding]; other site 1191523002860 Substrate Binding Site II [chemical binding]; other site 1191523002861 Substrate Binding Site I [chemical binding]; other site 1191523002862 Arginine repressor [Transcription]; Region: ArgR; COG1438 1191523002863 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1191523002864 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1191523002865 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1191523002866 feedback inhibition sensing region; other site 1191523002867 homohexameric interface [polypeptide binding]; other site 1191523002868 nucleotide binding site [chemical binding]; other site 1191523002869 N-acetyl-L-glutamate binding site [chemical binding]; other site 1191523002870 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1191523002871 heterotetramer interface [polypeptide binding]; other site 1191523002872 active site pocket [active] 1191523002873 cleavage site 1191523002874 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1191523002875 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191523002876 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1191523002877 active site 1191523002878 SdiA-regulated; Region: SdiA-regulated; cd09971 1191523002879 putative active site [active] 1191523002880 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 1191523002881 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1191523002882 Cl- selectivity filter; other site 1191523002883 Cl- binding residues [ion binding]; other site 1191523002884 pore gating glutamate residue; other site 1191523002885 dimer interface [polypeptide binding]; other site 1191523002886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1191523002887 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1191523002888 TrkA-C domain; Region: TrkA_C; pfam02080 1191523002889 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523002890 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523002891 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1191523002892 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1191523002893 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191523002894 active site 1191523002895 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1191523002896 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1191523002897 active site 1191523002898 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191523002899 dimer interface [polypeptide binding]; other site 1191523002900 substrate binding site [chemical binding]; other site 1191523002901 catalytic residues [active] 1191523002902 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1191523002903 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1191523002904 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523002905 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1191523002906 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523002907 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1191523002908 putative active site [active] 1191523002909 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191523002910 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1191523002911 cofactor binding site; other site 1191523002912 DNA binding site [nucleotide binding] 1191523002913 substrate interaction site [chemical binding]; other site 1191523002914 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191523002915 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1191523002916 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191523002917 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1191523002918 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1191523002919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523002920 Walker A/P-loop; other site 1191523002921 ATP binding site [chemical binding]; other site 1191523002922 Q-loop/lid; other site 1191523002923 ABC transporter signature motif; other site 1191523002924 Walker B; other site 1191523002925 D-loop; other site 1191523002926 H-loop/switch region; other site 1191523002927 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1191523002928 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191523002929 Walker A/P-loop; other site 1191523002930 ATP binding site [chemical binding]; other site 1191523002931 Q-loop/lid; other site 1191523002932 ABC transporter signature motif; other site 1191523002933 Walker B; other site 1191523002934 D-loop; other site 1191523002935 H-loop/switch region; other site 1191523002936 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191523002937 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523002938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523002939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523002940 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1191523002941 active site 1191523002942 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1191523002943 active site 1191523002944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191523002945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191523002946 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1191523002947 oligomerisation interface [polypeptide binding]; other site 1191523002948 mobile loop; other site 1191523002949 roof hairpin; other site 1191523002950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523002951 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1191523002952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191523002953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523002954 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191523002955 catalytic residues [active] 1191523002956 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1191523002957 L-aspartate oxidase; Provisional; Region: PRK06175 1191523002958 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1191523002959 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1191523002960 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1191523002961 dimerization interface [polypeptide binding]; other site 1191523002962 active site 1191523002963 quinolinate synthetase; Provisional; Region: PRK09375 1191523002964 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 1191523002965 ATP cone domain; Region: ATP-cone; pfam03477 1191523002966 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 1191523002967 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1191523002968 putative FMN binding site [chemical binding]; other site 1191523002969 NADPH bind site [chemical binding]; other site 1191523002970 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1191523002971 active site 1191523002972 catalytic residues [active] 1191523002973 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 1191523002974 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 1191523002975 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523002976 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1191523002977 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523002978 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523002979 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523002980 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191523002981 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191523002982 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191523002983 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1191523002984 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1191523002985 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1191523002986 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1191523002987 active site 1191523002988 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523002989 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523002990 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523002991 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1191523002992 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1191523002993 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523002994 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523002995 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523002996 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1191523002997 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1191523002998 active site 1191523002999 catalytic residues [active] 1191523003000 Right handed beta helix region; Region: Beta_helix; pfam13229 1191523003001 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003002 Ycf48-like protein; Provisional; Region: PRK13684 1191523003003 CotH protein; Region: CotH; pfam08757 1191523003004 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003005 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1191523003006 active site 1191523003007 catalytic residues [active] 1191523003008 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003009 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191523003010 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523003011 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1191523003012 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523003013 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523003014 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1191523003015 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1191523003016 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1191523003017 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1191523003018 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1191523003019 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1191523003020 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003021 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003022 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523003023 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523003024 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523003025 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523003026 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523003027 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523003028 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523003029 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1191523003030 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1191523003031 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1191523003032 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1191523003033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191523003034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191523003035 active site 1191523003036 catalytic tetrad [active] 1191523003037 short chain dehydrogenase; Provisional; Region: PRK07024 1191523003038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523003039 NAD(P) binding site [chemical binding]; other site 1191523003040 active site 1191523003041 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523003042 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1191523003043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523003044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1191523003045 TPR motif; other site 1191523003046 binding surface 1191523003047 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1191523003048 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1191523003049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523003050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523003051 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1191523003052 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1191523003053 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1191523003054 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1191523003055 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 1191523003056 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 1191523003057 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523003058 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523003059 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523003060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523003061 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1191523003062 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1191523003063 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1191523003064 G1 box; other site 1191523003065 GTP/Mg2+ binding site [chemical binding]; other site 1191523003066 Switch I region; other site 1191523003067 G2 box; other site 1191523003068 Switch II region; other site 1191523003069 G3 box; other site 1191523003070 G4 box; other site 1191523003071 G5 box; other site 1191523003072 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1191523003073 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1191523003074 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1191523003075 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1191523003076 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1191523003077 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1191523003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523003079 S-adenosylmethionine binding site [chemical binding]; other site 1191523003080 putative transposase OrfB; Reviewed; Region: PHA02517 1191523003081 Integrase core domain; Region: rve; pfam00665 1191523003082 Integrase core domain; Region: rve_3; pfam13683 1191523003083 Transposase; Region: HTH_Tnp_1; cl17663 1191523003084 amino acid transporter; Region: 2A0306; TIGR00909 1191523003085 Spore germination protein; Region: Spore_permease; cl17796 1191523003086 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1191523003087 Ligand Binding Site [chemical binding]; other site 1191523003088 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191523003089 Ligand Binding Site [chemical binding]; other site 1191523003090 Ion channel; Region: Ion_trans_2; pfam07885 1191523003091 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1191523003092 TrkA-N domain; Region: TrkA_N; pfam02254 1191523003093 TrkA-C domain; Region: TrkA_C; pfam02080 1191523003094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191523003095 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191523003096 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191523003097 PAS fold; Region: PAS_3; pfam08447 1191523003098 PAS domain S-box; Region: sensory_box; TIGR00229 1191523003099 PAS domain; Region: PAS; smart00091 1191523003100 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523003101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003102 putative active site [active] 1191523003103 heme pocket [chemical binding]; other site 1191523003104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003105 dimer interface [polypeptide binding]; other site 1191523003106 phosphorylation site [posttranslational modification] 1191523003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003108 ATP binding site [chemical binding]; other site 1191523003109 Mg2+ binding site [ion binding]; other site 1191523003110 G-X-G motif; other site 1191523003111 Putative methyltransferase; Region: Methyltransf_4; cl17290 1191523003112 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1191523003113 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1191523003114 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1191523003115 RF-1 domain; Region: RF-1; pfam00472 1191523003116 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1191523003117 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1191523003118 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1191523003119 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1191523003120 DsrC like protein; Region: DsrC; pfam04358 1191523003121 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1191523003122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1191523003123 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1191523003124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1191523003125 DNA binding residues [nucleotide binding] 1191523003126 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1191523003127 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1191523003128 nucleophile elbow; other site 1191523003129 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1191523003130 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1191523003131 active site 1191523003132 FMN binding site [chemical binding]; other site 1191523003133 substrate binding site [chemical binding]; other site 1191523003134 putative catalytic residue [active] 1191523003135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523003136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523003137 Uncharacterized conserved protein [Function unknown]; Region: COG1433 1191523003138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523003140 putative substrate translocation pore; other site 1191523003141 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1191523003142 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1191523003143 transmembrane helices; other site 1191523003144 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1191523003145 active site 1191523003146 homotetramer interface [polypeptide binding]; other site 1191523003147 homodimer interface [polypeptide binding]; other site 1191523003148 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1191523003149 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1191523003150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003151 Walker A motif; other site 1191523003152 ATP binding site [chemical binding]; other site 1191523003153 Walker B motif; other site 1191523003154 arginine finger; other site 1191523003155 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1191523003156 DnaA box-binding interface [nucleotide binding]; other site 1191523003157 DNA polymerase III subunit beta; Validated; Region: PRK05643 1191523003158 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1191523003159 putative DNA binding surface [nucleotide binding]; other site 1191523003160 dimer interface [polypeptide binding]; other site 1191523003161 beta-clamp/clamp loader binding surface; other site 1191523003162 beta-clamp/translesion DNA polymerase binding surface; other site 1191523003163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523003164 recombination protein F; Reviewed; Region: recF; PRK00064 1191523003165 Walker A/P-loop; other site 1191523003166 ATP binding site [chemical binding]; other site 1191523003167 Q-loop/lid; other site 1191523003168 ABC transporter signature motif; other site 1191523003169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523003170 ABC transporter signature motif; other site 1191523003171 Walker B; other site 1191523003172 D-loop; other site 1191523003173 H-loop/switch region; other site 1191523003174 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1191523003175 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1191523003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003177 Mg2+ binding site [ion binding]; other site 1191523003178 G-X-G motif; other site 1191523003179 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1191523003180 anchoring element; other site 1191523003181 dimer interface [polypeptide binding]; other site 1191523003182 ATP binding site [chemical binding]; other site 1191523003183 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1191523003184 active site 1191523003185 putative metal-binding site [ion binding]; other site 1191523003186 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1191523003187 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1191523003188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1191523003189 Divalent cation transporter; Region: MgtE; cl00786 1191523003190 DNA gyrase subunit A; Validated; Region: PRK05560 1191523003191 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1191523003192 CAP-like domain; other site 1191523003193 active site 1191523003194 primary dimer interface [polypeptide binding]; other site 1191523003195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003199 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003200 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191523003201 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1191523003202 Zn binding site [ion binding]; other site 1191523003203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191523003204 dimerization interface [polypeptide binding]; other site 1191523003205 putative DNA binding site [nucleotide binding]; other site 1191523003206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191523003207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523003208 S-adenosylmethionine binding site [chemical binding]; other site 1191523003209 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1191523003210 active site 1191523003211 catalytic triad [active] 1191523003212 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003213 Peptidase S46; Region: Peptidase_S46; pfam10459 1191523003214 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191523003215 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191523003216 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1191523003217 GIY-YIG motif/motif A; other site 1191523003218 putative active site [active] 1191523003219 putative metal binding site [ion binding]; other site 1191523003220 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1191523003221 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1191523003222 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1191523003223 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1191523003224 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1191523003225 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1191523003226 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1191523003227 Putative esterase; Region: Esterase; pfam00756 1191523003228 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1191523003229 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1191523003230 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1191523003231 active site 1191523003232 catalytic site [active] 1191523003233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523003234 S-adenosylmethionine binding site [chemical binding]; other site 1191523003235 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191523003236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191523003237 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1191523003238 catalytic loop [active] 1191523003239 iron binding site [ion binding]; other site 1191523003240 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1191523003241 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1191523003242 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1191523003243 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1191523003244 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1191523003245 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1191523003246 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1191523003247 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1191523003248 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003249 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 1191523003250 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1191523003251 arsenical-resistance protein; Region: acr3; TIGR00832 1191523003252 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1191523003253 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1191523003254 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1191523003255 active site 1191523003256 Predicted permease; Region: DUF318; cl17795 1191523003257 Predicted permease; Region: DUF318; cl17795 1191523003258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191523003259 dimerization interface [polypeptide binding]; other site 1191523003260 putative DNA binding site [nucleotide binding]; other site 1191523003261 putative Zn2+ binding site [ion binding]; other site 1191523003262 HAMP domain; Region: HAMP; pfam00672 1191523003263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003264 dimer interface [polypeptide binding]; other site 1191523003265 phosphorylation site [posttranslational modification] 1191523003266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003267 ATP binding site [chemical binding]; other site 1191523003268 Mg2+ binding site [ion binding]; other site 1191523003269 G-X-G motif; other site 1191523003270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003271 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523003272 active site 1191523003273 phosphorylation site [posttranslational modification] 1191523003274 intermolecular recognition site; other site 1191523003275 dimerization interface [polypeptide binding]; other site 1191523003276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003277 Walker A motif; other site 1191523003278 ATP binding site [chemical binding]; other site 1191523003279 Walker B motif; other site 1191523003280 arginine finger; other site 1191523003281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523003282 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1191523003283 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1191523003284 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1191523003285 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523003286 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1191523003287 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1191523003288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191523003289 molybdopterin cofactor binding site; other site 1191523003290 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191523003291 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1191523003292 putative molybdopterin cofactor binding site; other site 1191523003293 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1191523003294 Chromate transporter; Region: Chromate_transp; pfam02417 1191523003295 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1191523003296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523003297 FeS/SAM binding site; other site 1191523003298 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1191523003299 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1191523003300 trimer interface [polypeptide binding]; other site 1191523003301 dimer interface [polypeptide binding]; other site 1191523003302 putative active site [active] 1191523003303 MOSC domain; Region: MOSC; pfam03473 1191523003304 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1191523003305 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1191523003306 dimer interface [polypeptide binding]; other site 1191523003307 putative functional site; other site 1191523003308 putative MPT binding site; other site 1191523003309 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1191523003310 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1191523003311 GTP binding site; other site 1191523003312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523003313 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191523003314 substrate binding site [chemical binding]; other site 1191523003315 ATP binding site [chemical binding]; other site 1191523003316 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1191523003317 CoA binding domain; Region: CoA_binding_2; pfam13380 1191523003318 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1191523003319 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1191523003320 EamA-like transporter family; Region: EamA; pfam00892 1191523003321 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1191523003322 linker region; other site 1191523003323 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1191523003324 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1191523003325 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1191523003326 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1191523003327 proposed catalytic triad [active] 1191523003328 conserved cys residue [active] 1191523003329 serine racemase; Region: PLN02970 1191523003330 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1191523003331 tetramer interface [polypeptide binding]; other site 1191523003332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523003333 catalytic residue [active] 1191523003334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523003335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523003336 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1191523003337 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1191523003338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1191523003339 acyl transferase; Provisional; Region: luxD; PRK13604 1191523003340 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1191523003341 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1191523003342 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1191523003343 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1191523003344 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1191523003345 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1191523003346 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1191523003347 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1191523003348 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1191523003349 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191523003350 Rrf2 family protein; Region: rrf2_super; TIGR00738 1191523003351 Transcriptional regulator; Region: Rrf2; pfam02082 1191523003352 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1191523003353 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1191523003354 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1191523003355 Cytochrome c; Region: Cytochrom_C; pfam00034 1191523003356 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 1191523003357 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1191523003358 NosL; Region: NosL; cl01769 1191523003359 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1191523003360 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1191523003361 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191523003362 Walker A/P-loop; other site 1191523003363 ATP binding site [chemical binding]; other site 1191523003364 Q-loop/lid; other site 1191523003365 ABC transporter signature motif; other site 1191523003366 Walker B; other site 1191523003367 D-loop; other site 1191523003368 H-loop/switch region; other site 1191523003369 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523003370 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1191523003371 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1191523003372 Family of unknown function (DUF438); Region: DUF438; pfam04282 1191523003373 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1191523003374 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1191523003375 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 1191523003376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1191523003377 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1191523003378 Protein kinase domain; Region: Pkinase; pfam00069 1191523003379 active site 1191523003380 ATP binding site [chemical binding]; other site 1191523003381 substrate binding site [chemical binding]; other site 1191523003382 activation loop (A-loop); other site 1191523003383 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191523003384 Active Sites [active] 1191523003385 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1191523003386 glycogen synthase; Provisional; Region: glgA; PRK00654 1191523003387 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1191523003388 ADP-binding pocket [chemical binding]; other site 1191523003389 homodimer interface [polypeptide binding]; other site 1191523003390 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1191523003391 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523003392 putative active site [active] 1191523003393 putative metal binding site [ion binding]; other site 1191523003394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523003395 active site 1191523003396 motif I; other site 1191523003397 motif II; other site 1191523003398 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1191523003399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003400 Walker A motif; other site 1191523003401 ATP binding site [chemical binding]; other site 1191523003402 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1191523003403 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1191523003404 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1191523003405 active site 1191523003406 HslU subunit interaction site [polypeptide binding]; other site 1191523003407 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1191523003408 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1191523003409 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1191523003410 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 1191523003411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523003412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003413 active site 1191523003414 phosphorylation site [posttranslational modification] 1191523003415 intermolecular recognition site; other site 1191523003416 dimerization interface [polypeptide binding]; other site 1191523003417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191523003418 DNA binding site [nucleotide binding] 1191523003419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523003420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003421 dimer interface [polypeptide binding]; other site 1191523003422 phosphorylation site [posttranslational modification] 1191523003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003424 ATP binding site [chemical binding]; other site 1191523003425 Mg2+ binding site [ion binding]; other site 1191523003426 G-X-G motif; other site 1191523003427 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1191523003428 B12 binding domain; Region: B12-binding; pfam02310 1191523003429 B12 binding site [chemical binding]; other site 1191523003430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523003431 FeS/SAM binding site; other site 1191523003432 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1191523003433 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1191523003434 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191523003435 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1191523003436 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1191523003437 catalytic residues [active] 1191523003438 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1191523003439 nucleotide binding site [chemical binding]; other site 1191523003440 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1191523003441 dimer interface [polypeptide binding]; other site 1191523003442 putative threonine allosteric regulatory site; other site 1191523003443 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1191523003444 putative threonine allosteric regulatory site; other site 1191523003445 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1191523003446 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191523003447 homoserine kinase; Provisional; Region: PRK01212 1191523003448 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1191523003449 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1191523003450 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1191523003451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523003452 catalytic residue [active] 1191523003453 Secretory lipase; Region: LIP; pfam03583 1191523003454 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1191523003455 putative ligand binding site [chemical binding]; other site 1191523003456 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1191523003457 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1191523003458 Haemolytic domain; Region: Haemolytic; pfam01809 1191523003459 membrane protein insertase; Provisional; Region: PRK01318 1191523003460 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1191523003461 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1191523003462 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1191523003463 nucleophile elbow; other site 1191523003464 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1191523003465 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523003466 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1191523003467 TRAM domain; Region: TRAM; cl01282 1191523003468 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1191523003469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1191523003470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523003471 S-adenosylmethionine binding site [chemical binding]; other site 1191523003472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523003473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523003474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523003475 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1191523003476 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1191523003477 Predicted membrane protein [Function unknown]; Region: COG4485 1191523003478 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1191523003479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523003480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523003481 NAD(P) binding site [chemical binding]; other site 1191523003482 active site 1191523003483 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1191523003484 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1191523003485 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1191523003486 Cu(I) binding site [ion binding]; other site 1191523003487 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1191523003488 putative catalytic site [active] 1191523003489 putative metal binding site [ion binding]; other site 1191523003490 putative phosphate binding site [ion binding]; other site 1191523003491 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003492 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1191523003493 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1191523003494 NAD(P) binding site [chemical binding]; other site 1191523003495 homodimer interface [polypeptide binding]; other site 1191523003496 substrate binding site [chemical binding]; other site 1191523003497 active site 1191523003498 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1191523003499 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1191523003500 inhibitor-cofactor binding pocket; inhibition site 1191523003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523003502 catalytic residue [active] 1191523003503 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1191523003504 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1191523003505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1191523003506 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191523003507 pseudaminic acid synthase; Region: PseI; TIGR03586 1191523003508 NeuB family; Region: NeuB; pfam03102 1191523003509 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1191523003510 NeuB binding interface [polypeptide binding]; other site 1191523003511 putative substrate binding site [chemical binding]; other site 1191523003512 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1191523003513 active site 1191523003514 NTP binding site [chemical binding]; other site 1191523003515 metal binding triad [ion binding]; metal-binding site 1191523003516 antibiotic binding site [chemical binding]; other site 1191523003517 Protein of unknown function DUF86; Region: DUF86; pfam01934 1191523003518 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1191523003519 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1191523003520 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1191523003521 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1191523003522 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1191523003523 Beta-lactamase; Region: Beta-lactamase; pfam00144 1191523003524 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1191523003525 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1191523003526 substrate binding site [chemical binding]; other site 1191523003527 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1191523003528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191523003529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523003530 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1191523003531 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1191523003532 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1191523003533 tyrosine decarboxylase; Region: PLN02880 1191523003534 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1191523003535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523003536 catalytic residue [active] 1191523003537 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1191523003538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191523003539 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1191523003540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191523003541 motif 1; other site 1191523003542 dimer interface [polypeptide binding]; other site 1191523003543 active site 1191523003544 motif 2; other site 1191523003545 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1191523003546 putative deacylase active site [active] 1191523003547 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191523003548 active site 1191523003549 motif 3; other site 1191523003550 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1191523003551 anticodon binding site; other site 1191523003552 Predicted methyltransferases [General function prediction only]; Region: COG0313 1191523003553 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1191523003554 putative SAM binding site [chemical binding]; other site 1191523003555 putative homodimer interface [polypeptide binding]; other site 1191523003556 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1191523003557 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1191523003558 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1191523003559 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1191523003560 hypothetical protein; Provisional; Region: PRK07101 1191523003561 substrate-cofactor binding pocket; other site 1191523003562 para-aminobenzoate synthase component I; Validated; Region: PRK07093 1191523003563 DNA repair protein RadA; Provisional; Region: PRK11823 1191523003564 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1191523003565 Walker A motif/ATP binding site; other site 1191523003566 ATP binding site [chemical binding]; other site 1191523003567 Walker B motif; other site 1191523003568 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1191523003569 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1191523003570 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1191523003571 Walker A/P-loop; other site 1191523003572 ATP binding site [chemical binding]; other site 1191523003573 Q-loop/lid; other site 1191523003574 ABC transporter signature motif; other site 1191523003575 Walker B; other site 1191523003576 D-loop; other site 1191523003577 H-loop/switch region; other site 1191523003578 Protein of unknown function (DUF3681); Region: DUF3681; pfam12442 1191523003579 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1191523003580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523003581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003582 dimer interface [polypeptide binding]; other site 1191523003583 phosphorylation site [posttranslational modification] 1191523003584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003585 ATP binding site [chemical binding]; other site 1191523003586 Mg2+ binding site [ion binding]; other site 1191523003587 G-X-G motif; other site 1191523003588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523003589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003590 active site 1191523003591 phosphorylation site [posttranslational modification] 1191523003592 intermolecular recognition site; other site 1191523003593 dimerization interface [polypeptide binding]; other site 1191523003594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191523003595 DNA binding site [nucleotide binding] 1191523003596 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1191523003597 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1191523003598 dimerization interface 3.5A [polypeptide binding]; other site 1191523003599 active site 1191523003600 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523003601 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523003602 EamA-like transporter family; Region: EamA; pfam00892 1191523003603 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191523003604 EamA-like transporter family; Region: EamA; pfam00892 1191523003605 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1191523003606 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1191523003607 active site 1191523003608 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523003609 Peptidase family M28; Region: Peptidase_M28; pfam04389 1191523003610 metal binding site [ion binding]; metal-binding site 1191523003611 Fibronectin type 3 domain; Region: FN3; smart00060 1191523003612 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1191523003613 TrkA-N domain; Region: TrkA_N; pfam02254 1191523003614 TrkA-C domain; Region: TrkA_C; pfam02080 1191523003615 Cation transport protein; Region: TrkH; cl17365 1191523003616 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1191523003617 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523003618 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523003619 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1191523003620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003621 AAA domain; Region: AAA_22; pfam13401 1191523003622 Walker A motif; other site 1191523003623 ATP binding site [chemical binding]; other site 1191523003624 Walker B motif; other site 1191523003625 arginine finger; other site 1191523003626 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1191523003627 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1191523003628 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1191523003629 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1191523003630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523003631 Zn2+ binding site [ion binding]; other site 1191523003632 Mg2+ binding site [ion binding]; other site 1191523003633 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1191523003634 LytB protein; Region: LYTB; cl00507 1191523003635 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1191523003636 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 1191523003637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1191523003638 TPR motif; other site 1191523003639 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1191523003640 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1191523003641 Glutamate binding site [chemical binding]; other site 1191523003642 NAD binding site [chemical binding]; other site 1191523003643 catalytic residues [active] 1191523003644 Transposase; Region: HTH_Tnp_1; pfam01527 1191523003645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1191523003646 putative transposase OrfB; Reviewed; Region: PHA02517 1191523003647 HTH-like domain; Region: HTH_21; pfam13276 1191523003648 Integrase core domain; Region: rve; pfam00665 1191523003649 Integrase core domain; Region: rve_3; pfam13683 1191523003650 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003651 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1191523003652 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1191523003653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003654 Walker A motif; other site 1191523003655 ATP binding site [chemical binding]; other site 1191523003656 Walker B motif; other site 1191523003657 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1191523003658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523003659 binding surface 1191523003660 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523003661 TPR motif; other site 1191523003662 TPR repeat; Region: TPR_11; pfam13414 1191523003663 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1191523003664 FAD binding domain; Region: FAD_binding_4; pfam01565 1191523003665 Trm112p-like protein; Region: Trm112p; cl01066 1191523003666 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1191523003667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523003668 S-adenosylmethionine binding site [chemical binding]; other site 1191523003669 Predicted transcriptional regulator [Transcription]; Region: COG1959 1191523003670 Transcriptional regulator; Region: Rrf2; pfam02082 1191523003671 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523003672 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523003673 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1191523003674 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1191523003675 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523003676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191523003677 active site 1191523003678 GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103 1191523003679 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523003680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003681 active site 1191523003682 phosphorylation site [posttranslational modification] 1191523003683 intermolecular recognition site; other site 1191523003684 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523003685 dimerization interface [polypeptide binding]; other site 1191523003686 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523003687 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191523003688 anti sigma factor interaction site; other site 1191523003689 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1191523003690 regulatory phosphorylation site [posttranslational modification]; other site 1191523003691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523003692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003693 active site 1191523003694 phosphorylation site [posttranslational modification] 1191523003695 intermolecular recognition site; other site 1191523003696 dimerization interface [polypeptide binding]; other site 1191523003697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003698 Walker A motif; other site 1191523003699 ATP binding site [chemical binding]; other site 1191523003700 Walker B motif; other site 1191523003701 arginine finger; other site 1191523003702 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523003703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003704 PAS fold; Region: PAS_3; pfam08447 1191523003705 putative active site [active] 1191523003706 heme pocket [chemical binding]; other site 1191523003707 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523003708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003709 putative active site [active] 1191523003710 heme pocket [chemical binding]; other site 1191523003711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003712 dimer interface [polypeptide binding]; other site 1191523003713 phosphorylation site [posttranslational modification] 1191523003714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003715 ATP binding site [chemical binding]; other site 1191523003716 Mg2+ binding site [ion binding]; other site 1191523003717 G-X-G motif; other site 1191523003718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523003719 putative substrate translocation pore; other site 1191523003720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523003721 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1191523003722 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1191523003723 Peptidase family U32; Region: Peptidase_U32; pfam01136 1191523003724 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191523003725 anti sigma factor interaction site; other site 1191523003726 regulatory phosphorylation site [posttranslational modification]; other site 1191523003727 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523003728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1191523003729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1191523003730 active site 1191523003731 ATP binding site [chemical binding]; other site 1191523003732 substrate binding site [chemical binding]; other site 1191523003733 activation loop (A-loop); other site 1191523003734 PEGA domain; Region: PEGA; pfam08308 1191523003735 PEGA domain; Region: PEGA; pfam08308 1191523003736 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1191523003737 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191523003738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523003739 Walker A motif; other site 1191523003740 ATP binding site [chemical binding]; other site 1191523003741 Walker B motif; other site 1191523003742 arginine finger; other site 1191523003743 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1191523003744 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1191523003745 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1191523003746 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523003747 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523003748 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1191523003749 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1191523003750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523003751 putative substrate translocation pore; other site 1191523003752 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523003753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003754 active site 1191523003755 phosphorylation site [posttranslational modification] 1191523003756 intermolecular recognition site; other site 1191523003757 dimerization interface [polypeptide binding]; other site 1191523003758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191523003759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523003760 active site 1191523003761 phosphorylation site [posttranslational modification] 1191523003762 intermolecular recognition site; other site 1191523003763 dimerization interface [polypeptide binding]; other site 1191523003764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191523003765 DNA binding residues [nucleotide binding] 1191523003766 dimerization interface [polypeptide binding]; other site 1191523003767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003768 PAS fold; Region: PAS_3; pfam08447 1191523003769 putative active site [active] 1191523003770 heme pocket [chemical binding]; other site 1191523003771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003772 PAS domain; Region: PAS_9; pfam13426 1191523003773 putative active site [active] 1191523003774 heme pocket [chemical binding]; other site 1191523003775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003776 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523003777 putative active site [active] 1191523003778 heme pocket [chemical binding]; other site 1191523003779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003780 putative active site [active] 1191523003781 heme pocket [chemical binding]; other site 1191523003782 PAS domain S-box; Region: sensory_box; TIGR00229 1191523003783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003784 putative active site [active] 1191523003785 heme pocket [chemical binding]; other site 1191523003786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1191523003787 Histidine kinase; Region: HisKA_3; pfam07730 1191523003788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003789 ATP binding site [chemical binding]; other site 1191523003790 Mg2+ binding site [ion binding]; other site 1191523003791 G-X-G motif; other site 1191523003792 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523003793 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523003794 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523003795 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523003796 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523003797 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523003798 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191523003799 DNA-binding site [nucleotide binding]; DNA binding site 1191523003800 RNA-binding motif; other site 1191523003801 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191523003802 DNA-binding site [nucleotide binding]; DNA binding site 1191523003803 RNA-binding motif; other site 1191523003804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523003805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523003806 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1191523003807 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191523003808 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191523003809 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523003810 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191523003811 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1191523003812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523003813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523003814 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1191523003815 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523003816 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523003817 active site 1191523003818 Permease; Region: Permease; pfam02405 1191523003819 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1191523003820 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1191523003821 Walker A/P-loop; other site 1191523003822 ATP binding site [chemical binding]; other site 1191523003823 Q-loop/lid; other site 1191523003824 ABC transporter signature motif; other site 1191523003825 Walker B; other site 1191523003826 D-loop; other site 1191523003827 H-loop/switch region; other site 1191523003828 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1191523003829 mce related protein; Region: MCE; pfam02470 1191523003830 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1191523003831 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523003832 inhibitor-cofactor binding pocket; inhibition site 1191523003833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523003834 catalytic residue [active] 1191523003835 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1191523003836 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523003837 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523003838 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191523003839 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1191523003840 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1191523003841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523003842 motif II; other site 1191523003843 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1191523003844 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 1191523003845 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1191523003846 CotH protein; Region: CotH; pfam08757 1191523003847 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1191523003848 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1191523003849 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1191523003850 ArsC family; Region: ArsC; pfam03960 1191523003851 catalytic residue [active] 1191523003852 Peptidase family M49; Region: Peptidase_M49; pfam03571 1191523003853 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523003854 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1191523003855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523003856 motif II; other site 1191523003857 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1191523003858 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1191523003859 Protein of unknown function DUF82; Region: DUF82; pfam01927 1191523003860 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1191523003861 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1191523003862 MOSC domain; Region: MOSC; pfam03473 1191523003863 Protein of unknown function (DUF502); Region: DUF502; pfam04367 1191523003864 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1191523003865 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1191523003866 putative catalytic cysteine [active] 1191523003867 gamma-glutamyl kinase; Provisional; Region: PRK05429 1191523003868 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1191523003869 nucleotide binding site [chemical binding]; other site 1191523003870 homotetrameric interface [polypeptide binding]; other site 1191523003871 putative phosphate binding site [ion binding]; other site 1191523003872 putative allosteric binding site; other site 1191523003873 PUA domain; Region: PUA; pfam01472 1191523003874 Domain of unknown function DUF302; Region: DUF302; cl01364 1191523003875 GxxExxY protein; Region: GxxExxY; TIGR04256 1191523003876 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1191523003877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523003878 active site 1191523003879 HIGH motif; other site 1191523003880 nucleotide binding site [chemical binding]; other site 1191523003881 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1191523003882 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1191523003883 active site 1191523003884 KMSKS motif; other site 1191523003885 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1191523003886 tRNA binding surface [nucleotide binding]; other site 1191523003887 anticodon binding site; other site 1191523003888 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1191523003889 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1191523003890 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1191523003891 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1191523003892 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1191523003893 RNA binding site [nucleotide binding]; other site 1191523003894 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1191523003895 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1191523003896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523003897 ATP binding site [chemical binding]; other site 1191523003898 putative Mg++ binding site [ion binding]; other site 1191523003899 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1191523003900 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1191523003901 LabA_like proteins; Region: LabA_like; cd06167 1191523003902 putative metal binding site [ion binding]; other site 1191523003903 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1191523003904 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1191523003905 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1191523003906 ORF6N domain; Region: ORF6N; pfam10543 1191523003907 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1191523003908 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1191523003909 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1191523003910 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1191523003911 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523003912 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523003913 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523003914 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1191523003915 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191523003916 Na binding site [ion binding]; other site 1191523003917 Domain of unknown function DUF21; Region: DUF21; pfam01595 1191523003918 FOG: CBS domain [General function prediction only]; Region: COG0517 1191523003919 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191523003920 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1191523003922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191523003923 Coenzyme A binding pocket [chemical binding]; other site 1191523003924 PAS domain; Region: PAS_9; pfam13426 1191523003925 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523003926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523003927 putative active site [active] 1191523003928 heme pocket [chemical binding]; other site 1191523003929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523003930 dimer interface [polypeptide binding]; other site 1191523003931 phosphorylation site [posttranslational modification] 1191523003932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523003933 ATP binding site [chemical binding]; other site 1191523003934 Mg2+ binding site [ion binding]; other site 1191523003935 G-X-G motif; other site 1191523003936 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1191523003937 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1191523003938 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1191523003939 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1191523003940 cobalamin binding residues [chemical binding]; other site 1191523003941 putative BtuC binding residues; other site 1191523003942 dimer interface [polypeptide binding]; other site 1191523003943 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1191523003944 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1191523003945 Ligand binding site; other site 1191523003946 Putative Catalytic site; other site 1191523003947 DXD motif; other site 1191523003948 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1191523003949 catalytic nucleophile [active] 1191523003950 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 1191523003951 TQXA domain; Region: TQXA_dom; TIGR03934 1191523003952 Cna protein B-type domain; Region: Cna_B; pfam05738 1191523003953 Cna protein B-type domain; Region: Cna_B; pfam05738 1191523003954 Domain of unknown function DUF11; Region: DUF11; cl17728 1191523003955 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1191523003956 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1191523003957 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523003958 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523003959 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 1191523003960 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1191523003961 PA/protease or protease-like domain interface [polypeptide binding]; other site 1191523003962 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523003963 metal binding site [ion binding]; metal-binding site 1191523003964 PEGA domain; Region: PEGA; pfam08308 1191523003965 sucrose synthase; Region: sucr_synth; TIGR02470 1191523003966 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1191523003967 putative ADP-binding pocket [chemical binding]; other site 1191523003968 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 1191523003969 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1191523003970 putative ADP-binding pocket [chemical binding]; other site 1191523003971 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1191523003972 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523003973 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1191523003974 putative substrate binding site [chemical binding]; other site 1191523003975 putative ATP binding site [chemical binding]; other site 1191523003976 inorganic pyrophosphatase; Provisional; Region: PRK02230 1191523003977 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1191523003978 dimer interface [polypeptide binding]; other site 1191523003979 substrate binding site [chemical binding]; other site 1191523003980 metal binding sites [ion binding]; metal-binding site 1191523003981 amino acid transporter; Region: 2A0306; TIGR00909 1191523003982 Phosphate transporter family; Region: PHO4; cl00396 1191523003983 short chain dehydrogenase; Provisional; Region: PRK06197 1191523003984 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1191523003985 putative NAD(P) binding site [chemical binding]; other site 1191523003986 active site 1191523003987 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1191523003988 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1191523003989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523003990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523003991 binding surface 1191523003992 TPR motif; other site 1191523003993 TPR repeat; Region: TPR_11; pfam13414 1191523003994 TPR repeat; Region: TPR_11; pfam13414 1191523003995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523003996 binding surface 1191523003997 TPR motif; other site 1191523003998 TPR repeat; Region: TPR_11; pfam13414 1191523003999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523004000 TPR repeat; Region: TPR_11; pfam13414 1191523004001 binding surface 1191523004002 TPR motif; other site 1191523004003 TPR repeat; Region: TPR_11; pfam13414 1191523004004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523004005 binding surface 1191523004006 TPR motif; other site 1191523004007 TPR repeat; Region: TPR_11; pfam13414 1191523004008 TPR repeat; Region: TPR_11; pfam13414 1191523004009 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1191523004010 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191523004011 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191523004012 shikimate binding site; other site 1191523004013 NAD(P) binding site [chemical binding]; other site 1191523004014 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1191523004015 Putative zinc ribbon domain; Region: DUF164; pfam02591 1191523004016 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1191523004017 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1191523004018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1191523004019 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1191523004020 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1191523004021 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 1191523004022 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1191523004023 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1191523004024 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1191523004025 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1191523004026 conserved cys residue [active] 1191523004027 DNA primase; Validated; Region: dnaG; PRK05667 1191523004028 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1191523004029 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1191523004030 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1191523004031 active site 1191523004032 metal binding site [ion binding]; metal-binding site 1191523004033 interdomain interaction site; other site 1191523004034 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 1191523004035 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1191523004036 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1191523004037 active site 1191523004038 catalytic site [active] 1191523004039 PAS fold; Region: PAS; pfam00989 1191523004040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004041 putative active site [active] 1191523004042 heme pocket [chemical binding]; other site 1191523004043 PAS domain; Region: PAS_9; pfam13426 1191523004044 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191523004045 GAF domain; Region: GAF; pfam01590 1191523004046 PAS fold; Region: PAS_4; pfam08448 1191523004047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004048 putative active site [active] 1191523004049 heme pocket [chemical binding]; other site 1191523004050 PAS domain S-box; Region: sensory_box; TIGR00229 1191523004051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004052 putative active site [active] 1191523004053 heme pocket [chemical binding]; other site 1191523004054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004055 putative active site [active] 1191523004056 heme pocket [chemical binding]; other site 1191523004057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523004058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004059 ATP binding site [chemical binding]; other site 1191523004060 Mg2+ binding site [ion binding]; other site 1191523004061 G-X-G motif; other site 1191523004062 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523004063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004064 active site 1191523004065 phosphorylation site [posttranslational modification] 1191523004066 intermolecular recognition site; other site 1191523004067 dimerization interface [polypeptide binding]; other site 1191523004068 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 1191523004069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191523004070 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191523004071 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1191523004072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191523004073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523004074 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1191523004075 substrate binding site [chemical binding]; other site 1191523004076 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1191523004077 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1191523004078 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1191523004079 catalytic site [active] 1191523004080 subunit interface [polypeptide binding]; other site 1191523004081 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1191523004082 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1191523004083 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 1191523004084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191523004085 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 1191523004086 catalytic residues [active] 1191523004087 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 1191523004088 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1191523004089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523004090 catalytic residues [active] 1191523004091 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191523004092 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191523004093 dimer interface [polypeptide binding]; other site 1191523004094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523004095 catalytic residue [active] 1191523004096 serine O-acetyltransferase; Region: cysE; TIGR01172 1191523004097 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1191523004098 trimer interface [polypeptide binding]; other site 1191523004099 active site 1191523004100 substrate binding site [chemical binding]; other site 1191523004101 CoA binding site [chemical binding]; other site 1191523004102 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191523004103 DNA-binding site [nucleotide binding]; DNA binding site 1191523004104 RNA-binding motif; other site 1191523004105 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1191523004106 DinB superfamily; Region: DinB_2; pfam12867 1191523004107 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1191523004108 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1191523004109 active site 1191523004110 dimer interfaces [polypeptide binding]; other site 1191523004111 catalytic residues [active] 1191523004112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191523004113 MarR family; Region: MarR_2; pfam12802 1191523004114 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1191523004115 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1191523004116 active site 1191523004117 catalytic site [active] 1191523004118 metal binding site [ion binding]; metal-binding site 1191523004119 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1191523004120 GIY-YIG motif/motif A; other site 1191523004121 putative active site [active] 1191523004122 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1191523004123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191523004124 DNA-binding site [nucleotide binding]; DNA binding site 1191523004125 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191523004126 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523004127 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523004128 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523004129 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523004130 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1191523004131 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004132 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1191523004133 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004134 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1191523004135 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1191523004136 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004137 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1191523004138 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1191523004139 active site 1191523004140 intersubunit interface [polypeptide binding]; other site 1191523004141 catalytic residue [active] 1191523004142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191523004143 classical (c) SDRs; Region: SDR_c; cd05233 1191523004144 NAD(P) binding site [chemical binding]; other site 1191523004145 active site 1191523004146 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1191523004147 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1191523004148 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191523004149 D-galactonate transporter; Region: 2A0114; TIGR00893 1191523004150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523004151 putative substrate translocation pore; other site 1191523004152 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004153 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523004154 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191523004155 substrate binding site [chemical binding]; other site 1191523004156 ATP binding site [chemical binding]; other site 1191523004157 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1191523004158 GIY-YIG motif/motif A; other site 1191523004159 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1191523004160 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1191523004161 active site 1191523004162 substrate-binding site [chemical binding]; other site 1191523004163 metal-binding site [ion binding] 1191523004164 ATP binding site [chemical binding]; other site 1191523004165 aspartate aminotransferase; Provisional; Region: PRK05764 1191523004166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191523004167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523004168 homodimer interface [polypeptide binding]; other site 1191523004169 catalytic residue [active] 1191523004170 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1191523004171 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1191523004172 putative FMN binding site [chemical binding]; other site 1191523004173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523004174 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1191523004175 active site 1191523004176 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191523004177 putative trimer interface [polypeptide binding]; other site 1191523004178 putative CoA binding site [chemical binding]; other site 1191523004179 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1191523004180 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1191523004181 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1191523004182 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1191523004183 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1191523004184 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1191523004185 homotetramer interface [polypeptide binding]; other site 1191523004186 ligand binding site [chemical binding]; other site 1191523004187 catalytic site [active] 1191523004188 NAD binding site [chemical binding]; other site 1191523004189 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004191 active site 1191523004192 phosphorylation site [posttranslational modification] 1191523004193 intermolecular recognition site; other site 1191523004194 dimerization interface [polypeptide binding]; other site 1191523004195 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523004196 PAS domain; Region: PAS; smart00091 1191523004197 putative active site [active] 1191523004198 heme pocket [chemical binding]; other site 1191523004199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523004200 dimer interface [polypeptide binding]; other site 1191523004201 phosphorylation site [posttranslational modification] 1191523004202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004203 ATP binding site [chemical binding]; other site 1191523004204 Mg2+ binding site [ion binding]; other site 1191523004205 G-X-G motif; other site 1191523004206 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1191523004207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523004208 FeS/SAM binding site; other site 1191523004209 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1191523004210 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1191523004211 domain interfaces; other site 1191523004212 active site 1191523004213 AAA domain; Region: AAA_32; pfam13654 1191523004214 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1191523004215 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1191523004216 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523004217 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523004218 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523004219 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523004220 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1191523004221 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1191523004222 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1191523004223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191523004224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191523004225 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1191523004226 dimerization interface [polypeptide binding]; other site 1191523004227 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1191523004228 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1191523004229 dimer interface [polypeptide binding]; other site 1191523004230 active site 1191523004231 heme binding site [chemical binding]; other site 1191523004232 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1191523004233 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1191523004234 Beta-lactamase; Region: Beta-lactamase; pfam00144 1191523004235 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1191523004236 GTPase RsgA; Reviewed; Region: PRK01889 1191523004237 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523004238 RNA binding site [nucleotide binding]; other site 1191523004239 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1191523004240 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1191523004241 GTP/Mg2+ binding site [chemical binding]; other site 1191523004242 G4 box; other site 1191523004243 G5 box; other site 1191523004244 G1 box; other site 1191523004245 Switch I region; other site 1191523004246 G2 box; other site 1191523004247 G3 box; other site 1191523004248 Switch II region; other site 1191523004249 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1191523004250 active site lid residues [active] 1191523004251 substrate binding pocket [chemical binding]; other site 1191523004252 catalytic residues [active] 1191523004253 substrate-Mg2+ binding site; other site 1191523004254 aspartate-rich region 1; other site 1191523004255 aspartate-rich region 2; other site 1191523004256 Protein of unknown function (DUF422); Region: DUF422; cl00991 1191523004257 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1191523004258 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1191523004259 putative acyl-acceptor binding pocket; other site 1191523004260 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1191523004261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191523004262 active site 1191523004263 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1191523004264 phytoene desaturase; Region: crtI_fam; TIGR02734 1191523004265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523004266 glutamine synthetase, type I; Region: GlnA; TIGR00653 1191523004267 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1191523004268 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1191523004269 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1191523004270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191523004271 putative DNA binding site [nucleotide binding]; other site 1191523004272 putative Zn2+ binding site [ion binding]; other site 1191523004273 AsnC family; Region: AsnC_trans_reg; pfam01037 1191523004274 TIGR03546 family protein; Region: TIGR03546 1191523004275 TIGR03545 family protein; Region: TIGR03545 1191523004276 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1191523004277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004278 active site 1191523004279 phosphorylation site [posttranslational modification] 1191523004280 intermolecular recognition site; other site 1191523004281 dimerization interface [polypeptide binding]; other site 1191523004282 LytTr DNA-binding domain; Region: LytTR; smart00850 1191523004283 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191523004284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004285 PAS domain; Region: PAS_9; pfam13426 1191523004286 putative active site [active] 1191523004287 heme pocket [chemical binding]; other site 1191523004288 GAF domain; Region: GAF; pfam01590 1191523004289 GAF domain; Region: GAF_2; pfam13185 1191523004290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523004291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523004292 dimer interface [polypeptide binding]; other site 1191523004293 phosphorylation site [posttranslational modification] 1191523004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004295 ATP binding site [chemical binding]; other site 1191523004296 Mg2+ binding site [ion binding]; other site 1191523004297 G-X-G motif; other site 1191523004298 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1191523004299 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1191523004300 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191523004301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004302 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523004303 putative active site [active] 1191523004304 heme pocket [chemical binding]; other site 1191523004305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004306 putative active site [active] 1191523004307 heme pocket [chemical binding]; other site 1191523004308 PAS domain S-box; Region: sensory_box; TIGR00229 1191523004309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004310 putative active site [active] 1191523004311 heme pocket [chemical binding]; other site 1191523004312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523004313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523004314 dimer interface [polypeptide binding]; other site 1191523004315 phosphorylation site [posttranslational modification] 1191523004316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004317 ATP binding site [chemical binding]; other site 1191523004318 Mg2+ binding site [ion binding]; other site 1191523004319 G-X-G motif; other site 1191523004320 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1191523004321 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1191523004322 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191523004323 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523004324 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 1191523004325 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191523004326 IHF dimer interface [polypeptide binding]; other site 1191523004327 IHF - DNA interface [nucleotide binding]; other site 1191523004328 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1191523004329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1191523004330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523004331 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1191523004332 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1191523004333 ligand binding site [chemical binding]; other site 1191523004334 NAD binding site [chemical binding]; other site 1191523004335 tetramer interface [polypeptide binding]; other site 1191523004336 catalytic site [active] 1191523004337 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1191523004338 L-serine binding site [chemical binding]; other site 1191523004339 ACT domain interface; other site 1191523004340 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1191523004341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523004342 putative catalytic residue [active] 1191523004343 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1191523004344 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523004345 catalytic residues [active] 1191523004346 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1191523004347 Interdomain contacts; other site 1191523004348 Cytokine receptor motif; other site 1191523004349 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523004350 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523004351 active site 1191523004352 metal binding site [ion binding]; metal-binding site 1191523004353 photolyase PhrII; Region: phr2; TIGR00591 1191523004354 DNA photolyase; Region: DNA_photolyase; pfam00875 1191523004355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191523004356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1191523004357 phosphorylation site [posttranslational modification] 1191523004358 intermolecular recognition site; other site 1191523004359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191523004360 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191523004361 DNA binding residues [nucleotide binding] 1191523004362 dimerization interface [polypeptide binding]; other site 1191523004363 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523004364 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1191523004365 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523004366 N-terminal plug; other site 1191523004367 ligand-binding site [chemical binding]; other site 1191523004368 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 1191523004369 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1191523004370 putative active site [active] 1191523004371 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523004372 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523004373 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523004374 EVE domain; Region: EVE; cl00728 1191523004375 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1191523004376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191523004377 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191523004378 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1191523004379 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1191523004380 phosphofructokinase; Region: PFK_mixed; TIGR02483 1191523004381 active site 1191523004382 ADP/pyrophosphate binding site [chemical binding]; other site 1191523004383 dimerization interface [polypeptide binding]; other site 1191523004384 allosteric effector site; other site 1191523004385 fructose-1,6-bisphosphate binding site; other site 1191523004386 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1191523004387 RNA/DNA hybrid binding site [nucleotide binding]; other site 1191523004388 active site 1191523004389 phosphomannomutase CpsG; Provisional; Region: PRK15414 1191523004390 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1191523004391 active site 1191523004392 substrate binding site [chemical binding]; other site 1191523004393 metal binding site [ion binding]; metal-binding site 1191523004394 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1191523004395 active site 1191523004396 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191523004397 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191523004398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523004399 catalytic residue [active] 1191523004400 oligoendopeptidase F; Region: pepF; TIGR00181 1191523004401 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1191523004402 active site 1191523004403 Zn binding site [ion binding]; other site 1191523004404 OPT oligopeptide transporter protein; Region: OPT; pfam03169 1191523004405 putative oligopeptide transporter, OPT family; Region: TIGR00733 1191523004406 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1191523004407 dimer interface [polypeptide binding]; other site 1191523004408 active site 1191523004409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1191523004410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1191523004411 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1191523004412 active site 1191523004413 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1191523004414 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1191523004415 acyl-activating enzyme (AAE) consensus motif; other site 1191523004416 putative AMP binding site [chemical binding]; other site 1191523004417 putative active site [active] 1191523004418 putative CoA binding site [chemical binding]; other site 1191523004419 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1191523004420 active site 1191523004421 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1191523004422 UbiA prenyltransferase family; Region: UbiA; pfam01040 1191523004423 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191523004424 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1191523004425 substrate binding site [chemical binding]; other site 1191523004426 oxyanion hole (OAH) forming residues; other site 1191523004427 trimer interface [polypeptide binding]; other site 1191523004428 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1191523004429 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1191523004430 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1191523004431 dimer interface [polypeptide binding]; other site 1191523004432 tetramer interface [polypeptide binding]; other site 1191523004433 PYR/PP interface [polypeptide binding]; other site 1191523004434 TPP binding site [chemical binding]; other site 1191523004435 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1191523004436 TPP-binding site; other site 1191523004437 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1191523004438 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1191523004439 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191523004440 MarR family; Region: MarR; pfam01047 1191523004441 MarR family; Region: MarR_2; cl17246 1191523004442 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1191523004443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523004444 S-adenosylmethionine binding site [chemical binding]; other site 1191523004445 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1191523004446 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1191523004447 active site 1191523004448 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 1191523004449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523004450 FeS/SAM binding site; other site 1191523004451 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1191523004452 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1191523004453 dimerization interface [polypeptide binding]; other site 1191523004454 putative ATP binding site [chemical binding]; other site 1191523004455 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1191523004456 GrpE; Region: GrpE; pfam01025 1191523004457 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1191523004458 dimer interface [polypeptide binding]; other site 1191523004459 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1191523004460 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1191523004461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191523004462 HSP70 interaction site [polypeptide binding]; other site 1191523004463 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1191523004464 Zn binding sites [ion binding]; other site 1191523004465 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1191523004466 dimer interface [polypeptide binding]; other site 1191523004467 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1191523004468 Helix-hairpin-helix motif; Region: HHH; pfam00633 1191523004469 helix-hairpin-helix signature motif; other site 1191523004470 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1191523004471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1191523004472 S-adenosylmethionine binding site [chemical binding]; other site 1191523004473 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1191523004474 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1191523004475 active site 1191523004476 (T/H)XGH motif; other site 1191523004477 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191523004478 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1191523004479 Na binding site [ion binding]; other site 1191523004480 SurA N-terminal domain; Region: SurA_N_3; cl07813 1191523004481 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191523004482 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1191523004483 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191523004484 shikimate kinase; Reviewed; Region: aroK; PRK00131 1191523004485 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1191523004486 ADP binding site [chemical binding]; other site 1191523004487 magnesium binding site [ion binding]; other site 1191523004488 putative shikimate binding site; other site 1191523004489 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1191523004490 active site 1191523004491 dimer interface [polypeptide binding]; other site 1191523004492 metal binding site [ion binding]; metal-binding site 1191523004493 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1191523004494 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1191523004495 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1191523004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523004497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523004498 putative substrate translocation pore; other site 1191523004499 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1191523004500 ferredoxin; Validated; Region: PRK07118 1191523004501 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523004502 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1191523004503 ApbE family; Region: ApbE; pfam02424 1191523004504 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1191523004505 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1191523004506 FMN-binding domain; Region: FMN_bind; pfam04205 1191523004507 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1191523004508 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1191523004509 SLBB domain; Region: SLBB; pfam10531 1191523004510 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523004511 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523004512 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1191523004513 putative active site [active] 1191523004514 putative metal binding site [ion binding]; other site 1191523004515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523004516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523004517 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1191523004518 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1191523004519 ligand binding site; other site 1191523004520 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1191523004521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523004522 inhibitor-cofactor binding pocket; inhibition site 1191523004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523004524 catalytic residue [active] 1191523004525 flagellin modification protein A; Provisional; Region: PRK09186 1191523004526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523004527 NAD(P) binding site [chemical binding]; other site 1191523004528 active site 1191523004529 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191523004530 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1191523004531 NeuB family; Region: NeuB; pfam03102 1191523004532 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1191523004533 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1191523004534 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1191523004535 conserved hypothetical protein; Region: TIGR02231 1191523004536 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1191523004537 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1191523004538 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1191523004539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523004540 putative active site [active] 1191523004541 heme pocket [chemical binding]; other site 1191523004542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523004543 dimer interface [polypeptide binding]; other site 1191523004544 phosphorylation site [posttranslational modification] 1191523004545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004546 ATP binding site [chemical binding]; other site 1191523004547 Mg2+ binding site [ion binding]; other site 1191523004548 G-X-G motif; other site 1191523004549 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523004550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004551 active site 1191523004552 phosphorylation site [posttranslational modification] 1191523004553 intermolecular recognition site; other site 1191523004554 dimerization interface [polypeptide binding]; other site 1191523004555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523004556 Walker A motif; other site 1191523004557 ATP binding site [chemical binding]; other site 1191523004558 Walker B motif; other site 1191523004559 arginine finger; other site 1191523004560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523004561 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191523004562 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523004563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523004564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523004565 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523004566 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523004567 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1191523004568 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1191523004569 putative FMN binding site [chemical binding]; other site 1191523004570 MgtC family; Region: MgtC; pfam02308 1191523004571 Predicted membrane protein [Function unknown]; Region: COG3174 1191523004572 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1191523004573 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1191523004574 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1191523004575 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1191523004576 putative active site [active] 1191523004577 putative substrate binding site [chemical binding]; other site 1191523004578 putative cosubstrate binding site; other site 1191523004579 catalytic site [active] 1191523004580 Cupin domain; Region: Cupin_2; pfam07883 1191523004581 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1191523004582 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523004583 Pectic acid lyase; Region: Pec_lyase; pfam09492 1191523004584 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1191523004585 active site 1191523004586 catalytic triad [active] 1191523004587 oxyanion hole [active] 1191523004588 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 1191523004589 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1191523004590 substrate binding site [chemical binding]; other site 1191523004591 ligand binding site [chemical binding]; other site 1191523004592 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 1191523004593 substrate binding site [chemical binding]; other site 1191523004594 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004595 Kelch motif; Region: Kelch_6; pfam13964 1191523004596 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1191523004597 Kelch domain; Region: Kelch; smart00612 1191523004598 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1191523004599 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004600 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1191523004601 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1191523004602 putative NAD(P) binding site [chemical binding]; other site 1191523004603 homodimer interface [polypeptide binding]; other site 1191523004604 homotetramer interface [polypeptide binding]; other site 1191523004605 active site 1191523004606 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1191523004607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1191523004608 Heavy-metal-associated domain; Region: HMA; pfam00403 1191523004609 metal-binding site [ion binding] 1191523004610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191523004611 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1191523004612 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1191523004613 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 1191523004614 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1191523004615 Low-spin heme binding site [chemical binding]; other site 1191523004616 Putative water exit pathway; other site 1191523004617 Binuclear center (active site) [active] 1191523004618 Putative proton exit pathway; other site 1191523004619 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1191523004620 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1191523004621 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1191523004622 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1191523004623 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1191523004624 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523004625 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1191523004626 FixH; Region: FixH; pfam05751 1191523004627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1191523004628 Family description; Region: DsbD_2; pfam13386 1191523004629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1191523004630 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191523004631 catalytic core [active] 1191523004632 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1191523004633 putative active site [active] 1191523004634 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1191523004635 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1191523004636 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523004637 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1191523004638 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1191523004639 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 1191523004640 putative catalytic residues [active] 1191523004641 nucleotide binding site [chemical binding]; other site 1191523004642 aspartate binding site [chemical binding]; other site 1191523004643 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1191523004644 dimer interface [polypeptide binding]; other site 1191523004645 putative threonine allosteric regulatory site; other site 1191523004646 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1191523004647 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1191523004648 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1191523004649 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1191523004650 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191523004651 homodimer interface [polypeptide binding]; other site 1191523004652 substrate-cofactor binding pocket; other site 1191523004653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523004654 catalytic residue [active] 1191523004655 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1191523004656 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1191523004657 Peptidase S46; Region: Peptidase_S46; pfam10459 1191523004658 Peptidase S46; Region: Peptidase_S46; pfam10459 1191523004659 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 1191523004660 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1191523004661 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523004662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523004663 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1191523004664 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004665 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1191523004666 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004667 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004668 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1191523004669 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191523004671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191523004672 active site 1191523004673 catalytic tetrad [active] 1191523004674 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1191523004675 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1191523004676 heme binding site [chemical binding]; other site 1191523004677 ferroxidase pore; other site 1191523004678 ferroxidase diiron center [ion binding]; other site 1191523004679 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191523004680 dimer interface [polypeptide binding]; other site 1191523004681 ADP-ribose binding site [chemical binding]; other site 1191523004682 active site 1191523004683 nudix motif; other site 1191523004684 metal binding site [ion binding]; metal-binding site 1191523004685 glutamate racemase; Provisional; Region: PRK00865 1191523004686 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 1191523004687 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191523004688 metal binding triad; other site 1191523004689 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1191523004690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523004691 Zn2+ binding site [ion binding]; other site 1191523004692 Mg2+ binding site [ion binding]; other site 1191523004693 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1191523004694 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1191523004695 tyrosine phenol-lyase; Provisional; Region: PRK13237 1191523004696 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1191523004697 substrate binding site [chemical binding]; other site 1191523004698 tetramer interface [polypeptide binding]; other site 1191523004699 catalytic residue [active] 1191523004700 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1191523004701 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 1191523004702 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1191523004703 DNA methylase; Region: N6_N4_Mtase; cl17433 1191523004704 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1191523004705 Ligand Binding Site [chemical binding]; other site 1191523004706 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1191523004707 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1191523004708 HIGH motif; other site 1191523004709 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1191523004710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523004711 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523004712 active site 1191523004713 KMSKS motif; other site 1191523004714 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1191523004715 tRNA binding surface [nucleotide binding]; other site 1191523004716 seryl-tRNA synthetase; Provisional; Region: PRK05431 1191523004717 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1191523004718 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1191523004719 dimer interface [polypeptide binding]; other site 1191523004720 active site 1191523004721 motif 1; other site 1191523004722 motif 2; other site 1191523004723 motif 3; other site 1191523004724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1191523004725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191523004726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523004727 Walker A/P-loop; other site 1191523004728 ATP binding site [chemical binding]; other site 1191523004729 Q-loop/lid; other site 1191523004730 ABC transporter signature motif; other site 1191523004731 Walker B; other site 1191523004732 D-loop; other site 1191523004733 H-loop/switch region; other site 1191523004734 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1191523004735 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1191523004736 NAD binding site [chemical binding]; other site 1191523004737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1191523004738 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191523004739 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1191523004740 Walker A/P-loop; other site 1191523004741 ATP binding site [chemical binding]; other site 1191523004742 Q-loop/lid; other site 1191523004743 ABC transporter signature motif; other site 1191523004744 Walker B; other site 1191523004745 D-loop; other site 1191523004746 H-loop/switch region; other site 1191523004747 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1191523004748 AMP binding site [chemical binding]; other site 1191523004749 metal binding site [ion binding]; metal-binding site 1191523004750 active site 1191523004751 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523004752 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523004753 putative active site [active] 1191523004754 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1191523004755 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1191523004756 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1191523004757 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1191523004758 active site 1191523004759 substrate-binding site [chemical binding]; other site 1191523004760 metal-binding site [ion binding] 1191523004761 ATP binding site [chemical binding]; other site 1191523004762 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1191523004763 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1191523004764 ligand binding site [chemical binding]; other site 1191523004765 NAD binding site [chemical binding]; other site 1191523004766 catalytic site [active] 1191523004767 homodimer interface [polypeptide binding]; other site 1191523004768 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 1191523004769 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1191523004770 heme-binding residues [chemical binding]; other site 1191523004771 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 1191523004772 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 1191523004773 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1191523004774 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523004775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004776 active site 1191523004777 phosphorylation site [posttranslational modification] 1191523004778 intermolecular recognition site; other site 1191523004779 dimerization interface [polypeptide binding]; other site 1191523004780 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1191523004781 lipoyl attachment site [posttranslational modification]; other site 1191523004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523004783 active site 1191523004784 phosphorylation site [posttranslational modification] 1191523004785 intermolecular recognition site; other site 1191523004786 dimerization interface [polypeptide binding]; other site 1191523004787 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1191523004788 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1191523004789 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1191523004790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523004791 dimerization interface [polypeptide binding]; other site 1191523004792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523004793 dimer interface [polypeptide binding]; other site 1191523004794 phosphorylation site [posttranslational modification] 1191523004795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523004796 ATP binding site [chemical binding]; other site 1191523004797 G-X-G motif; other site 1191523004798 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1191523004799 heme-binding residues [chemical binding]; other site 1191523004800 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 1191523004801 heme-binding residues [chemical binding]; other site 1191523004802 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1191523004803 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1191523004804 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1191523004805 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1191523004806 Chorismate mutase type II; Region: CM_2; cl00693 1191523004807 Prephenate dehydratase; Region: PDT; pfam00800 1191523004808 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1191523004809 putative L-Phe binding site [chemical binding]; other site 1191523004810 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 1191523004811 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1191523004812 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1191523004813 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1191523004814 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004815 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 1191523004816 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1191523004817 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1191523004818 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1191523004819 active site 1191523004820 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 1191523004821 putative ligand binding site [chemical binding]; other site 1191523004822 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1191523004823 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1191523004824 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191523004825 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1191523004826 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191523004827 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523004828 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523004829 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523004830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523004831 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523004832 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1191523004833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523004834 putative substrate translocation pore; other site 1191523004835 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191523004836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191523004837 nucleotide binding site [chemical binding]; other site 1191523004838 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; pfam01532 1191523004839 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1191523004840 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1191523004841 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191523004842 trimer interface [polypeptide binding]; other site 1191523004843 substrate binding site [chemical binding]; other site 1191523004844 Mn binding site [ion binding]; other site 1191523004845 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1191523004846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523004847 putative substrate translocation pore; other site 1191523004848 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1191523004849 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1191523004850 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1191523004851 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1191523004852 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 1191523004853 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1191523004854 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1191523004855 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1191523004856 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1191523004857 active site 1191523004858 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1191523004859 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1191523004860 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1191523004861 Na binding site [ion binding]; other site 1191523004862 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1191523004863 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523004864 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1191523004865 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1191523004866 Fn3 associated; Region: Fn3_assoc; pfam13287 1191523004867 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1191523004868 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191523004869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191523004870 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1191523004871 Na binding site [ion binding]; other site 1191523004872 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1191523004873 catalytic residues [active] 1191523004874 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1191523004875 oligomerisation interface [polypeptide binding]; other site 1191523004876 mobile loop; other site 1191523004877 roof hairpin; other site 1191523004878 Cupin domain; Region: Cupin_2; pfam07883 1191523004879 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523004880 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523004881 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1191523004882 EamA-like transporter family; Region: EamA; pfam00892 1191523004883 EamA-like transporter family; Region: EamA; pfam00892 1191523004884 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1191523004885 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1191523004886 TAP-like protein; Region: Abhydrolase_4; pfam08386 1191523004887 CHASE2 domain; Region: CHASE2; pfam05226 1191523004888 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1191523004889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523004890 Walker A motif; other site 1191523004891 ATP binding site [chemical binding]; other site 1191523004892 Walker B motif; other site 1191523004893 arginine finger; other site 1191523004894 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1191523004895 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1191523004896 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1191523004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523004898 FeS/SAM binding site; other site 1191523004899 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1191523004900 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1191523004901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523004902 Walker A motif; other site 1191523004903 ATP binding site [chemical binding]; other site 1191523004904 Walker B motif; other site 1191523004905 arginine finger; other site 1191523004906 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523004907 Lipopolysaccharide-assembly; Region: LptE; cl01125 1191523004908 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 1191523004909 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523004910 DXD motif; other site 1191523004911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523004912 binding surface 1191523004913 TPR repeat; Region: TPR_11; pfam13414 1191523004914 TPR motif; other site 1191523004915 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523004916 heat shock protein HtpX; Provisional; Region: PRK03982 1191523004917 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1191523004918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1191523004919 binding surface 1191523004920 TPR motif; other site 1191523004921 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1191523004922 Family description; Region: VCBS; pfam13517 1191523004923 Family description; Region: VCBS; pfam13517 1191523004924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191523004925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191523004926 Walker A/P-loop; other site 1191523004927 ATP binding site [chemical binding]; other site 1191523004928 Q-loop/lid; other site 1191523004929 ABC transporter signature motif; other site 1191523004930 Walker B; other site 1191523004931 D-loop; other site 1191523004932 H-loop/switch region; other site 1191523004933 CcmB protein; Region: CcmB; cl17444 1191523004934 aspartate aminotransferase; Provisional; Region: PRK05764 1191523004935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191523004936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523004937 homodimer interface [polypeptide binding]; other site 1191523004938 catalytic residue [active] 1191523004939 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1191523004940 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1191523004941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523004942 ATP binding site [chemical binding]; other site 1191523004943 putative Mg++ binding site [ion binding]; other site 1191523004944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523004945 nucleotide binding region [chemical binding]; other site 1191523004946 ATP-binding site [chemical binding]; other site 1191523004947 TRCF domain; Region: TRCF; pfam03461 1191523004948 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 1191523004949 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1191523004950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523004951 FeS/SAM binding site; other site 1191523004952 TRAM domain; Region: TRAM; pfam01938 1191523004953 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523004954 Sporulation related domain; Region: SPOR; pfam05036 1191523004955 Sporulation related domain; Region: SPOR; pfam05036 1191523004956 CAAX protease self-immunity; Region: Abi; pfam02517 1191523004957 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1191523004958 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1191523004959 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1191523004960 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1191523004961 putative ligand binding site [chemical binding]; other site 1191523004962 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1191523004963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523004964 TPR motif; other site 1191523004965 TPR repeat; Region: TPR_11; pfam13414 1191523004966 binding surface 1191523004967 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1191523004968 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1191523004969 dimerization interface [polypeptide binding]; other site 1191523004970 ATP binding site [chemical binding]; other site 1191523004971 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1191523004972 dimerization interface [polypeptide binding]; other site 1191523004973 ATP binding site [chemical binding]; other site 1191523004974 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1191523004975 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1191523004976 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1191523004977 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1191523004978 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191523004979 Beta-Casp domain; Region: Beta-Casp; smart01027 1191523004980 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1191523004981 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523004982 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1191523004983 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1191523004984 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1191523004985 PA14 domain; Region: PA14; cl08459 1191523004986 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1191523004987 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1191523004988 putative active site [active] 1191523004989 putative catalytic site [active] 1191523004990 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1191523004991 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523004992 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523004993 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523004994 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1191523004995 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1191523004996 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523004997 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191523004998 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1191523004999 putative metal binding residues [ion binding]; other site 1191523005000 signature motif; other site 1191523005001 dimer interface [polypeptide binding]; other site 1191523005002 active site 1191523005003 polyP binding site; other site 1191523005004 substrate binding site [chemical binding]; other site 1191523005005 acceptor-phosphate pocket; other site 1191523005006 MgtC family; Region: MgtC; pfam02308 1191523005007 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 1191523005008 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1191523005009 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1191523005010 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1191523005011 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1191523005012 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523005013 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191523005014 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191523005015 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1191523005016 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1191523005017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191523005018 active site 1191523005019 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 1191523005020 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523005021 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523005022 putative active site [active] 1191523005023 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1191523005024 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1191523005025 Zn binding site [ion binding]; other site 1191523005026 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1191523005027 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1191523005028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523005029 inhibitor-cofactor binding pocket; inhibition site 1191523005030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523005031 catalytic residue [active] 1191523005032 MerC mercury resistance protein; Region: MerC; cl03934 1191523005033 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1191523005034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523005035 putative active site [active] 1191523005036 heme pocket [chemical binding]; other site 1191523005037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523005038 dimer interface [polypeptide binding]; other site 1191523005039 phosphorylation site [posttranslational modification] 1191523005040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523005041 ATP binding site [chemical binding]; other site 1191523005042 Mg2+ binding site [ion binding]; other site 1191523005043 G-X-G motif; other site 1191523005044 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523005045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523005046 active site 1191523005047 phosphorylation site [posttranslational modification] 1191523005048 intermolecular recognition site; other site 1191523005049 dimerization interface [polypeptide binding]; other site 1191523005050 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 1191523005051 active site 1191523005052 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191523005053 AMP nucleosidase; Provisional; Region: PRK07115 1191523005054 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1191523005055 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1191523005056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523005057 FtsX-like permease family; Region: FtsX; pfam02687 1191523005058 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1191523005059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523005060 FtsX-like permease family; Region: FtsX; pfam02687 1191523005061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191523005062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191523005063 Walker A/P-loop; other site 1191523005064 ATP binding site [chemical binding]; other site 1191523005065 Q-loop/lid; other site 1191523005066 ABC transporter signature motif; other site 1191523005067 Walker B; other site 1191523005068 D-loop; other site 1191523005069 H-loop/switch region; other site 1191523005070 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1191523005071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523005072 S-adenosylmethionine binding site [chemical binding]; other site 1191523005073 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1191523005074 DinB family; Region: DinB; cl17821 1191523005075 DinB superfamily; Region: DinB_2; pfam12867 1191523005076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523005077 active site 1191523005078 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1191523005079 putative active site [active] 1191523005080 nucleotide binding site [chemical binding]; other site 1191523005081 nudix motif; other site 1191523005082 putative metal binding site [ion binding]; other site 1191523005083 four helix bundle protein; Region: TIGR02436 1191523005084 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1191523005085 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1191523005086 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1191523005087 NADP binding site [chemical binding]; other site 1191523005088 homopentamer interface [polypeptide binding]; other site 1191523005089 substrate binding site [chemical binding]; other site 1191523005090 active site 1191523005091 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1191523005092 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1191523005093 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1191523005094 substrate binding pocket [chemical binding]; other site 1191523005095 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1191523005096 B12 binding site [chemical binding]; other site 1191523005097 cobalt ligand [ion binding]; other site 1191523005098 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1191523005099 Phosphotransferase enzyme family; Region: APH; pfam01636 1191523005100 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1191523005101 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1191523005102 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1191523005103 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1191523005104 Substrate binding site; other site 1191523005105 metal-binding site 1191523005106 Predicted acyl esterases [General function prediction only]; Region: COG2936 1191523005107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523005108 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1191523005109 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1191523005110 Domain of unknown function (DUF386); Region: DUF386; cl01047 1191523005111 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 1191523005112 deoxyhypusine synthase; Region: dhys; TIGR00321 1191523005113 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1191523005114 23S rRNA interface [nucleotide binding]; other site 1191523005115 L3 interface [polypeptide binding]; other site 1191523005116 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1191523005117 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1191523005118 rRNA interaction site [nucleotide binding]; other site 1191523005119 S8 interaction site; other site 1191523005120 putative laminin-1 binding site; other site 1191523005121 elongation factor Ts; Provisional; Region: tsf; PRK09377 1191523005122 UBA/TS-N domain; Region: UBA; pfam00627 1191523005123 Elongation factor TS; Region: EF_TS; pfam00889 1191523005124 Elongation factor TS; Region: EF_TS; pfam00889 1191523005125 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1191523005126 putative nucleotide binding site [chemical binding]; other site 1191523005127 uridine monophosphate binding site [chemical binding]; other site 1191523005128 homohexameric interface [polypeptide binding]; other site 1191523005129 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1191523005130 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1191523005131 hinge region; other site 1191523005132 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1191523005133 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1191523005134 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1191523005135 putative NAD(P) binding site [chemical binding]; other site 1191523005136 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1191523005137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1191523005138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191523005139 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523005140 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523005141 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1191523005142 putative metal binding site [ion binding]; other site 1191523005143 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523005144 hypothetical protein; Provisional; Region: PRK11820 1191523005145 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1191523005146 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1191523005147 AAA domain; Region: AAA_33; pfam13671 1191523005148 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1191523005149 catalytic site [active] 1191523005150 G-X2-G-X-G-K; other site 1191523005151 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1191523005152 Fe-S cluster binding site [ion binding]; other site 1191523005153 active site 1191523005154 replicative DNA helicase; Region: DnaB; TIGR00665 1191523005155 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1191523005156 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1191523005157 Walker A motif; other site 1191523005158 ATP binding site [chemical binding]; other site 1191523005159 Walker B motif; other site 1191523005160 DNA binding loops [nucleotide binding] 1191523005161 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1191523005162 endonuclease IV; Provisional; Region: PRK01060 1191523005163 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1191523005164 AP (apurinic/apyrimidinic) site pocket; other site 1191523005165 DNA interaction; other site 1191523005166 Metal-binding active site; metal-binding site 1191523005167 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1191523005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523005169 NAD(P) binding site [chemical binding]; other site 1191523005170 active site 1191523005171 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1191523005172 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1191523005173 GatB domain; Region: GatB_Yqey; smart00845 1191523005174 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1191523005175 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1191523005176 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1191523005177 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191523005178 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1191523005179 transmembrane helices; other site 1191523005180 Domain of unknown function DUF302; Region: DUF302; cl01364 1191523005181 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191523005182 HSP70 interaction site [polypeptide binding]; other site 1191523005183 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1191523005184 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1191523005185 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1191523005186 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1191523005187 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1191523005188 putative RNA binding site [nucleotide binding]; other site 1191523005189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523005190 S-adenosylmethionine binding site [chemical binding]; other site 1191523005191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523005192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523005193 putative substrate translocation pore; other site 1191523005194 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1191523005195 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 1191523005196 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1191523005197 Domain of unknown function (DUF3395); Region: DUF3395; pfam11875 1191523005198 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1191523005199 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1191523005200 Walker A/P-loop; other site 1191523005201 ATP binding site [chemical binding]; other site 1191523005202 Q-loop/lid; other site 1191523005203 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1191523005204 ABC transporter signature motif; other site 1191523005205 Walker B; other site 1191523005206 D-loop; other site 1191523005207 H-loop/switch region; other site 1191523005208 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1191523005209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523005210 FeS/SAM binding site; other site 1191523005211 HemN C-terminal domain; Region: HemN_C; pfam06969 1191523005212 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1191523005213 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1191523005214 putative oligomer interface [polypeptide binding]; other site 1191523005215 putative RNA binding site [nucleotide binding]; other site 1191523005216 transcription termination factor NusA; Region: NusA; TIGR01953 1191523005217 NusA N-terminal domain; Region: NusA_N; pfam08529 1191523005218 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1191523005219 RNA binding site [nucleotide binding]; other site 1191523005220 homodimer interface [polypeptide binding]; other site 1191523005221 NusA-like KH domain; Region: KH_5; pfam13184 1191523005222 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1191523005223 G-X-X-G motif; other site 1191523005224 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1191523005225 translation initiation factor IF-2; Region: IF-2; TIGR00487 1191523005226 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1191523005227 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1191523005228 G1 box; other site 1191523005229 putative GEF interaction site [polypeptide binding]; other site 1191523005230 GTP/Mg2+ binding site [chemical binding]; other site 1191523005231 Switch I region; other site 1191523005232 G2 box; other site 1191523005233 G3 box; other site 1191523005234 Switch II region; other site 1191523005235 G4 box; other site 1191523005236 G5 box; other site 1191523005237 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1191523005238 Translation-initiation factor 2; Region: IF-2; pfam11987 1191523005239 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1191523005240 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1191523005241 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1191523005242 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1191523005243 RNA binding site [nucleotide binding]; other site 1191523005244 active site 1191523005245 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1191523005246 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1191523005247 active site 1191523005248 Riboflavin kinase; Region: Flavokinase; smart00904 1191523005249 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1191523005250 16S/18S rRNA binding site [nucleotide binding]; other site 1191523005251 S13e-L30e interaction site [polypeptide binding]; other site 1191523005252 25S rRNA binding site [nucleotide binding]; other site 1191523005253 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1191523005254 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1191523005255 RNase E interface [polypeptide binding]; other site 1191523005256 trimer interface [polypeptide binding]; other site 1191523005257 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1191523005258 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1191523005259 RNase E interface [polypeptide binding]; other site 1191523005260 trimer interface [polypeptide binding]; other site 1191523005261 active site 1191523005262 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1191523005263 putative nucleic acid binding region [nucleotide binding]; other site 1191523005264 G-X-X-G motif; other site 1191523005265 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1191523005266 RNA binding site [nucleotide binding]; other site 1191523005267 domain interface; other site 1191523005268 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1191523005269 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1191523005270 FMN binding site [chemical binding]; other site 1191523005271 active site 1191523005272 catalytic residues [active] 1191523005273 substrate binding site [chemical binding]; other site 1191523005274 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1191523005275 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1191523005276 homodimer interface [polypeptide binding]; other site 1191523005277 oligonucleotide binding site [chemical binding]; other site 1191523005278 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1191523005279 active site 1191523005280 intersubunit interactions; other site 1191523005281 catalytic residue [active] 1191523005282 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1191523005283 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1191523005284 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1191523005285 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1191523005286 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1191523005287 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1191523005288 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1191523005289 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1191523005290 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1191523005291 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1191523005292 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1191523005293 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1191523005294 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1191523005295 active site 1191523005296 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1191523005297 Na2 binding site [ion binding]; other site 1191523005298 putative substrate binding site 1 [chemical binding]; other site 1191523005299 Na binding site 1 [ion binding]; other site 1191523005300 putative substrate binding site 2 [chemical binding]; other site 1191523005301 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1191523005302 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1191523005303 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1191523005304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523005305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523005306 DNA binding residues [nucleotide binding] 1191523005307 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1191523005308 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1191523005309 NusB family; Region: NusB; pfam01029 1191523005310 putative RNA binding site [nucleotide binding]; other site 1191523005311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523005312 S-adenosylmethionine binding site [chemical binding]; other site 1191523005313 Helix-turn-helix domain; Region: HTH_25; pfam13413 1191523005314 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1191523005315 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1191523005316 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1191523005317 nucleotide binding pocket [chemical binding]; other site 1191523005318 K-X-D-G motif; other site 1191523005319 catalytic site [active] 1191523005320 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1191523005321 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1191523005322 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1191523005323 Dimer interface [polypeptide binding]; other site 1191523005324 BRCT sequence motif; other site 1191523005325 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191523005326 anti sigma factor interaction site; other site 1191523005327 regulatory phosphorylation site [posttranslational modification]; other site 1191523005328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523005329 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1191523005330 active site 1191523005331 motif I; other site 1191523005332 motif II; other site 1191523005333 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191523005334 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1191523005335 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1191523005336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523005337 Zn2+ binding site [ion binding]; other site 1191523005338 Mg2+ binding site [ion binding]; other site 1191523005339 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1191523005340 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1191523005341 active site 1191523005342 Int/Topo IB signature motif; other site 1191523005343 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1191523005344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1191523005345 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191523005346 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1191523005347 Walker A/P-loop; other site 1191523005348 ATP binding site [chemical binding]; other site 1191523005349 Q-loop/lid; other site 1191523005350 ABC transporter signature motif; other site 1191523005351 Walker B; other site 1191523005352 D-loop; other site 1191523005353 H-loop/switch region; other site 1191523005354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1191523005355 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1191523005356 putative metal binding site; other site 1191523005357 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1191523005358 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1191523005359 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1191523005360 putative transposase OrfB; Reviewed; Region: PHA02517 1191523005361 HTH-like domain; Region: HTH_21; pfam13276 1191523005362 Integrase core domain; Region: rve; pfam00665 1191523005363 Integrase core domain; Region: rve_3; pfam13683 1191523005364 Transposase; Region: HTH_Tnp_1; pfam01527 1191523005365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1191523005366 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1191523005367 catalytic residues [active] 1191523005368 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523005369 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1191523005370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523005371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523005372 DNA binding residues [nucleotide binding] 1191523005373 regulatory protein UhpC; Provisional; Region: PRK11663 1191523005374 GTPase Era; Reviewed; Region: era; PRK00089 1191523005375 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1191523005376 G1 box; other site 1191523005377 GTP/Mg2+ binding site [chemical binding]; other site 1191523005378 Switch I region; other site 1191523005379 G2 box; other site 1191523005380 Switch II region; other site 1191523005381 G3 box; other site 1191523005382 G4 box; other site 1191523005383 G5 box; other site 1191523005384 KH domain; Region: KH_2; pfam07650 1191523005385 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191523005386 EamA-like transporter family; Region: EamA; pfam00892 1191523005387 Acylphosphatase; Region: Acylphosphatase; pfam00708 1191523005388 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1191523005389 homotrimer interaction site [polypeptide binding]; other site 1191523005390 zinc binding site [ion binding]; other site 1191523005391 CDP-binding sites; other site 1191523005392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191523005393 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191523005394 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1191523005395 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1191523005396 putative active site [active] 1191523005397 catalytic triad [active] 1191523005398 putative dimer interface [polypeptide binding]; other site 1191523005399 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1191523005400 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1191523005401 tetramer interface [polypeptide binding]; other site 1191523005402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523005403 catalytic residue [active] 1191523005404 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1191523005405 active site 1191523005406 catalytic site [active] 1191523005407 substrate binding site [chemical binding]; other site 1191523005408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523005409 active site 1191523005410 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1191523005411 iron-sulfur cluster [ion binding]; other site 1191523005412 [2Fe-2S] cluster binding site [ion binding]; other site 1191523005413 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1191523005414 heme bH binding site [chemical binding]; other site 1191523005415 intrachain domain interface; other site 1191523005416 heme bL binding site [chemical binding]; other site 1191523005417 interchain domain interface [polypeptide binding]; other site 1191523005418 Qo binding site; other site 1191523005419 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1191523005420 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1191523005421 DNA binding residues [nucleotide binding] 1191523005422 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1191523005423 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1191523005424 putative [Fe4-S4] binding site [ion binding]; other site 1191523005425 putative molybdopterin cofactor binding site [chemical binding]; other site 1191523005426 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1191523005427 putative molybdopterin cofactor binding site; other site 1191523005428 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1191523005429 4Fe-4S binding domain; Region: Fer4; cl02805 1191523005430 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1191523005431 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1191523005432 putative inner membrane protein; Provisional; Region: PRK11099 1191523005433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1191523005434 active site residue [active] 1191523005435 RmuC family; Region: RmuC; pfam02646 1191523005436 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1191523005437 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1191523005438 Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cl02575 1191523005439 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1191523005440 active site 1191523005441 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1191523005442 FAD binding site [chemical binding]; other site 1191523005443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523005444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523005445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191523005446 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1191523005447 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1191523005448 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523005449 Septum formation initiator; Region: DivIC; cl17659 1191523005450 recombination factor protein RarA; Reviewed; Region: PRK13342 1191523005451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523005452 Walker A motif; other site 1191523005453 ATP binding site [chemical binding]; other site 1191523005454 Walker B motif; other site 1191523005455 arginine finger; other site 1191523005456 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1191523005457 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1191523005458 DNA protecting protein DprA; Region: dprA; TIGR00732 1191523005459 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191523005460 Hexamer/Pentamer interface [polypeptide binding]; other site 1191523005461 central pore; other site 1191523005462 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 1191523005463 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1191523005464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523005465 Walker A motif; other site 1191523005466 ATP binding site [chemical binding]; other site 1191523005467 Walker B motif; other site 1191523005468 arginine finger; other site 1191523005469 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1191523005470 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1191523005471 GAF domain; Region: GAF_2; pfam13185 1191523005472 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1191523005473 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1191523005474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523005475 Walker A motif; other site 1191523005476 ATP binding site [chemical binding]; other site 1191523005477 Walker B motif; other site 1191523005478 arginine finger; other site 1191523005479 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1191523005480 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1191523005481 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1191523005482 active site 1191523005483 dimerization interface [polypeptide binding]; other site 1191523005484 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1191523005485 oligomerization interface [polypeptide binding]; other site 1191523005486 active site 1191523005487 metal binding site [ion binding]; metal-binding site 1191523005488 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1191523005489 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1191523005490 active site 1191523005491 ATP-binding site [chemical binding]; other site 1191523005492 pantoate-binding site; other site 1191523005493 HXXH motif; other site 1191523005494 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1191523005495 Flavoprotein; Region: Flavoprotein; pfam02441 1191523005496 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1191523005497 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1191523005498 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1191523005499 tetramerization interface [polypeptide binding]; other site 1191523005500 active site 1191523005501 cytidylate kinase; Provisional; Region: cmk; PRK00023 1191523005502 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1191523005503 CMP-binding site; other site 1191523005504 The sites determining sugar specificity; other site 1191523005505 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1191523005506 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1191523005507 RNA binding site [nucleotide binding]; other site 1191523005508 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1191523005509 RNA binding site [nucleotide binding]; other site 1191523005510 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523005511 RNA binding site [nucleotide binding]; other site 1191523005512 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523005513 RNA binding site [nucleotide binding]; other site 1191523005514 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1191523005515 RNA binding site [nucleotide binding]; other site 1191523005516 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1191523005517 RNA binding site [nucleotide binding]; other site 1191523005518 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1191523005519 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1191523005520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523005521 FeS/SAM binding site; other site 1191523005522 TRAM domain; Region: TRAM; cl01282 1191523005523 starch binding outer membrane protein SusD; Region: SusD; cl17845 1191523005524 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1191523005525 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1191523005526 dimerization interface 3.5A [polypeptide binding]; other site 1191523005527 active site 1191523005528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191523005529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523005530 NAD(P) binding site [chemical binding]; other site 1191523005531 active site 1191523005532 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1191523005533 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1191523005534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191523005535 substrate binding site [chemical binding]; other site 1191523005536 oxyanion hole (OAH) forming residues; other site 1191523005537 trimer interface [polypeptide binding]; other site 1191523005538 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523005539 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523005540 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523005541 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523005542 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523005543 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523005544 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1191523005545 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1191523005546 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523005547 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523005548 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523005549 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523005550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1191523005551 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1191523005552 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1191523005553 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1191523005554 GIY-YIG motif/motif A; other site 1191523005555 active site 1191523005556 catalytic site [active] 1191523005557 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1191523005558 GIY-YIG motif/motif A; other site 1191523005559 putative active site [active] 1191523005560 putative metal binding site [ion binding]; other site 1191523005561 outer membrane protein A; Reviewed; Region: PRK10808 1191523005562 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1191523005563 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191523005564 ligand binding site [chemical binding]; other site 1191523005565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523005566 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1191523005567 putative active site [active] 1191523005568 heme pocket [chemical binding]; other site 1191523005569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523005570 dimer interface [polypeptide binding]; other site 1191523005571 phosphorylation site [posttranslational modification] 1191523005572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523005573 ATP binding site [chemical binding]; other site 1191523005574 Mg2+ binding site [ion binding]; other site 1191523005575 G-X-G motif; other site 1191523005576 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523005577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523005578 active site 1191523005579 phosphorylation site [posttranslational modification] 1191523005580 intermolecular recognition site; other site 1191523005581 dimerization interface [polypeptide binding]; other site 1191523005582 Peptidase M30; Region: Peptidase_M30; pfam10460 1191523005583 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523005584 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1191523005585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523005586 FeS/SAM binding site; other site 1191523005587 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1191523005588 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191523005589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191523005590 Coenzyme A binding pocket [chemical binding]; other site 1191523005591 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 1191523005592 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523005593 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1191523005594 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1191523005595 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523005596 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1191523005597 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1191523005598 generic binding surface II; other site 1191523005599 ssDNA binding site; other site 1191523005600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523005601 ATP binding site [chemical binding]; other site 1191523005602 putative Mg++ binding site [ion binding]; other site 1191523005603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523005604 nucleotide binding region [chemical binding]; other site 1191523005605 ATP-binding site [chemical binding]; other site 1191523005606 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1191523005607 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1191523005608 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1191523005609 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1191523005610 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1191523005611 substrate binding site; other site 1191523005612 dimer interface; other site 1191523005613 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1191523005614 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1191523005615 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1191523005616 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191523005617 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191523005618 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191523005619 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191523005620 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1191523005621 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1191523005622 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1191523005623 putative acyl-acceptor binding pocket; other site 1191523005624 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1191523005625 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 1191523005626 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1191523005627 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191523005628 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1191523005629 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1191523005630 Walker A/P-loop; other site 1191523005631 ATP binding site [chemical binding]; other site 1191523005632 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1191523005633 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1191523005634 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1191523005635 ABC transporter signature motif; other site 1191523005636 Walker B; other site 1191523005637 D-loop; other site 1191523005638 H-loop/switch region; other site 1191523005639 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523005640 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523005641 Yip1 domain; Region: Yip1; pfam04893 1191523005642 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1191523005643 triosephosphate isomerase; Provisional; Region: PRK14565 1191523005644 substrate binding site [chemical binding]; other site 1191523005645 dimer interface [polypeptide binding]; other site 1191523005646 catalytic triad [active] 1191523005647 NifU-like domain; Region: NifU; pfam01106 1191523005648 antiporter inner membrane protein; Provisional; Region: PRK11670 1191523005649 Domain of unknown function DUF59; Region: DUF59; pfam01883 1191523005650 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1191523005651 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1191523005652 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1191523005653 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1191523005654 FeoA domain; Region: FeoA; pfam04023 1191523005655 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1191523005656 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1191523005657 FeoA domain; Region: FeoA; pfam04023 1191523005658 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1191523005659 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1191523005660 G1 box; other site 1191523005661 GTP/Mg2+ binding site [chemical binding]; other site 1191523005662 Switch I region; other site 1191523005663 G2 box; other site 1191523005664 G3 box; other site 1191523005665 Switch II region; other site 1191523005666 G4 box; other site 1191523005667 G5 box; other site 1191523005668 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1191523005669 Nucleoside recognition; Region: Gate; pfam07670 1191523005670 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1191523005671 polyphosphate kinase; Provisional; Region: PRK05443 1191523005672 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1191523005673 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1191523005674 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1191523005675 putative domain interface [polypeptide binding]; other site 1191523005676 putative active site [active] 1191523005677 catalytic site [active] 1191523005678 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1191523005679 putative domain interface [polypeptide binding]; other site 1191523005680 putative active site [active] 1191523005681 catalytic site [active] 1191523005682 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1191523005683 catalytic motif [active] 1191523005684 Zn binding site [ion binding]; other site 1191523005685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523005686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523005687 phosphorylation site [posttranslational modification] 1191523005688 dimer interface [polypeptide binding]; other site 1191523005689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523005690 ATP binding site [chemical binding]; other site 1191523005691 Mg2+ binding site [ion binding]; other site 1191523005692 G-X-G motif; other site 1191523005693 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1191523005694 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1191523005695 GDP-binding site [chemical binding]; other site 1191523005696 ACT binding site; other site 1191523005697 IMP binding site; other site 1191523005698 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191523005699 anti sigma factor interaction site; other site 1191523005700 regulatory phosphorylation site [posttranslational modification]; other site 1191523005701 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1191523005702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523005703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523005704 DNA binding residues [nucleotide binding] 1191523005705 GAF domain; Region: GAF_3; pfam13492 1191523005706 GAF domain; Region: GAF_2; pfam13185 1191523005707 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523005708 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523005709 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191523005710 anti sigma factor interaction site; other site 1191523005711 regulatory phosphorylation site [posttranslational modification]; other site 1191523005712 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1191523005713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523005714 ATP binding site [chemical binding]; other site 1191523005715 Mg2+ binding site [ion binding]; other site 1191523005716 G-X-G motif; other site 1191523005717 GAF domain; Region: GAF; cl17456 1191523005718 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523005719 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523005720 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1191523005721 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 1191523005722 Protein export membrane protein; Region: SecD_SecF; pfam02355 1191523005723 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1191523005724 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1191523005725 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1191523005726 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1191523005727 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1191523005728 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1191523005729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1191523005730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1191523005731 dimer interface [polypeptide binding]; other site 1191523005732 ssDNA binding site [nucleotide binding]; other site 1191523005733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191523005734 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1191523005735 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1191523005736 putative active site [active] 1191523005737 catalytic residue [active] 1191523005738 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1191523005739 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1191523005740 5S rRNA interface [nucleotide binding]; other site 1191523005741 CTC domain interface [polypeptide binding]; other site 1191523005742 L16 interface [polypeptide binding]; other site 1191523005743 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1191523005744 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1191523005745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523005746 active site 1191523005747 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1191523005748 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1191523005749 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523005750 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523005751 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523005752 ribonuclease R; Region: RNase_R; TIGR02063 1191523005753 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523005754 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523005755 RNB domain; Region: RNB; pfam00773 1191523005756 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1191523005757 RNA binding site [nucleotide binding]; other site 1191523005758 Family of unknown function (DUF490); Region: DUF490; pfam04357 1191523005759 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1191523005760 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1191523005761 active site 1191523005762 HIGH motif; other site 1191523005763 nucleotide binding site [chemical binding]; other site 1191523005764 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1191523005765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523005766 putative ribose interaction site [chemical binding]; other site 1191523005767 putative ADP binding site [chemical binding]; other site 1191523005768 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1191523005769 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1191523005770 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1191523005771 active site 1191523005772 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 1191523005773 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1191523005774 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1191523005775 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1191523005776 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1191523005777 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1191523005778 trimer interface [polypeptide binding]; other site 1191523005779 active site 1191523005780 UDP-GlcNAc binding site [chemical binding]; other site 1191523005781 lipid binding site [chemical binding]; lipid-binding site 1191523005782 periplasmic chaperone; Provisional; Region: PRK10780 1191523005783 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1191523005784 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1191523005785 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1191523005786 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523005787 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523005788 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523005789 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191523005790 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523005791 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1191523005792 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1191523005793 catalytic residue [active] 1191523005794 putative FPP diphosphate binding site; other site 1191523005795 putative FPP binding hydrophobic cleft; other site 1191523005796 dimer interface [polypeptide binding]; other site 1191523005797 putative IPP diphosphate binding site; other site 1191523005798 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1191523005799 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191523005800 minor groove reading motif; other site 1191523005801 helix-hairpin-helix signature motif; other site 1191523005802 substrate binding pocket [chemical binding]; other site 1191523005803 active site 1191523005804 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1191523005805 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 1191523005806 active site 1191523005807 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523005808 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 1191523005809 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1191523005810 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523005811 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1191523005812 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1191523005813 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523005814 GTP-binding protein Der; Reviewed; Region: PRK00093 1191523005815 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1191523005816 G1 box; other site 1191523005817 GTP/Mg2+ binding site [chemical binding]; other site 1191523005818 Switch I region; other site 1191523005819 G2 box; other site 1191523005820 Switch II region; other site 1191523005821 G3 box; other site 1191523005822 G4 box; other site 1191523005823 G5 box; other site 1191523005824 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1191523005825 G1 box; other site 1191523005826 GTP/Mg2+ binding site [chemical binding]; other site 1191523005827 Switch I region; other site 1191523005828 G2 box; other site 1191523005829 G3 box; other site 1191523005830 Switch II region; other site 1191523005831 G4 box; other site 1191523005832 G5 box; other site 1191523005833 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1191523005834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191523005835 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191523005836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523005837 active site 1191523005838 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1191523005839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523005840 Zn2+ binding site [ion binding]; other site 1191523005841 Mg2+ binding site [ion binding]; other site 1191523005842 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1191523005843 synthetase active site [active] 1191523005844 NTP binding site [chemical binding]; other site 1191523005845 metal binding site [ion binding]; metal-binding site 1191523005846 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1191523005847 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1191523005848 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1191523005849 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191523005850 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1191523005851 Hexamer interface [polypeptide binding]; other site 1191523005852 Putative hexagonal pore residue; other site 1191523005853 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191523005854 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191523005855 Hexamer interface [polypeptide binding]; other site 1191523005856 Hexagonal pore residue; other site 1191523005857 YbbR-like protein; Region: YbbR; pfam07949 1191523005858 Z1 domain; Region: Z1; pfam10593 1191523005859 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1191523005860 thymidylate kinase; Region: DTMP_kinase; TIGR00041 1191523005861 TMP-binding site; other site 1191523005862 ATP-binding site [chemical binding]; other site 1191523005863 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1191523005864 C-terminal peptidase (prc); Region: prc; TIGR00225 1191523005865 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1191523005866 protein binding site [polypeptide binding]; other site 1191523005867 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1191523005868 Catalytic dyad [active] 1191523005869 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1191523005870 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1191523005871 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1191523005872 active site 1191523005873 catalytic site [active] 1191523005874 substrate binding site [chemical binding]; other site 1191523005875 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1191523005876 GIY-YIG motif/motif A; other site 1191523005877 active site 1191523005878 catalytic site [active] 1191523005879 putative DNA binding site [nucleotide binding]; other site 1191523005880 metal binding site [ion binding]; metal-binding site 1191523005881 UvrB/uvrC motif; Region: UVR; pfam02151 1191523005882 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1191523005883 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1191523005884 oligomer interface [polypeptide binding]; other site 1191523005885 metal binding site [ion binding]; metal-binding site 1191523005886 metal binding site [ion binding]; metal-binding site 1191523005887 Cl binding site [ion binding]; other site 1191523005888 aspartate ring; other site 1191523005889 basic sphincter; other site 1191523005890 putative hydrophobic gate; other site 1191523005891 periplasmic entrance; other site 1191523005892 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1191523005893 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523005894 putative active site [active] 1191523005895 metal binding site [ion binding]; metal-binding site 1191523005896 homodimer binding site [polypeptide binding]; other site 1191523005897 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1191523005898 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1191523005899 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1191523005900 homodimer interface [polypeptide binding]; other site 1191523005901 NADP binding site [chemical binding]; other site 1191523005902 substrate binding site [chemical binding]; other site 1191523005903 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1191523005904 intersubunit interface [polypeptide binding]; other site 1191523005905 active site 1191523005906 catalytic residue [active] 1191523005907 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1191523005908 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191523005909 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1191523005910 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1191523005911 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1191523005912 hinge; other site 1191523005913 active site 1191523005914 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1191523005915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1191523005916 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191523005917 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191523005918 nucleotide binding site [chemical binding]; other site 1191523005919 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1191523005920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191523005921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191523005922 ABC transporter; Region: ABC_tran_2; pfam12848 1191523005923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191523005924 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523005925 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1191523005926 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1191523005927 active site 1191523005928 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1191523005929 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1191523005930 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191523005931 ligand binding site [chemical binding]; other site 1191523005932 flexible hinge region; other site 1191523005933 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1191523005934 putative switch regulator; other site 1191523005935 non-specific DNA interactions [nucleotide binding]; other site 1191523005936 DNA binding site [nucleotide binding] 1191523005937 sequence specific DNA binding site [nucleotide binding]; other site 1191523005938 putative cAMP binding site [chemical binding]; other site 1191523005939 cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434 1191523005940 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1191523005941 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1191523005942 Phosphoglycerate kinase; Region: PGK; pfam00162 1191523005943 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1191523005944 substrate binding site [chemical binding]; other site 1191523005945 hinge regions; other site 1191523005946 ADP binding site [chemical binding]; other site 1191523005947 catalytic site [active] 1191523005948 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1191523005949 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1191523005950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191523005951 ATP binding site [chemical binding]; other site 1191523005952 putative Mg++ binding site [ion binding]; other site 1191523005953 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1191523005954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191523005955 nucleotide binding region [chemical binding]; other site 1191523005956 ATP-binding site [chemical binding]; other site 1191523005957 HRDC domain; Region: HRDC; pfam00570 1191523005958 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1191523005959 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191523005960 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191523005961 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1191523005962 propionate/acetate kinase; Provisional; Region: PRK12379 1191523005963 short chain dehydrogenase; Provisional; Region: PRK08339 1191523005964 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1191523005965 putative NAD(P) binding site [chemical binding]; other site 1191523005966 putative active site [active] 1191523005967 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1191523005968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191523005969 SnoaL-like domain; Region: SnoaL_2; pfam12680 1191523005970 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1191523005971 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1191523005972 MutS domain I; Region: MutS_I; pfam01624 1191523005973 MutS domain II; Region: MutS_II; pfam05188 1191523005974 MutS domain III; Region: MutS_III; pfam05192 1191523005975 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1191523005976 Walker A/P-loop; other site 1191523005977 ATP binding site [chemical binding]; other site 1191523005978 Q-loop/lid; other site 1191523005979 ABC transporter signature motif; other site 1191523005980 Walker B; other site 1191523005981 D-loop; other site 1191523005982 H-loop/switch region; other site 1191523005983 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1191523005984 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1191523005985 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1191523005986 prephenate dehydrogenase; Validated; Region: PRK06545 1191523005987 prephenate dehydrogenase; Validated; Region: PRK08507 1191523005988 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1191523005989 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1191523005990 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1191523005991 active site 1191523005992 catalytic site [active] 1191523005993 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1191523005994 Predicted membrane protein [Function unknown]; Region: COG1511 1191523005995 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191523005996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1191523005997 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523005998 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523005999 Outer membrane efflux protein; Region: OEP; pfam02321 1191523006000 Outer membrane efflux protein; Region: OEP; pfam02321 1191523006001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191523006002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191523006003 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1191523006004 Gram-negative porin; Region: Porin_4; pfam13609 1191523006005 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1191523006006 FMN-binding domain; Region: FMN_bind; pfam04205 1191523006007 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 1191523006008 heat shock protein 90; Provisional; Region: PRK05218 1191523006009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006010 ATP binding site [chemical binding]; other site 1191523006011 Mg2+ binding site [ion binding]; other site 1191523006012 G-X-G motif; other site 1191523006013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523006014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523006015 NAD(P) binding site [chemical binding]; other site 1191523006016 active site 1191523006017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006019 phosphorylation site [posttranslational modification] 1191523006020 dimer interface [polypeptide binding]; other site 1191523006021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006022 ATP binding site [chemical binding]; other site 1191523006023 Mg2+ binding site [ion binding]; other site 1191523006024 G-X-G motif; other site 1191523006025 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523006026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006027 active site 1191523006028 phosphorylation site [posttranslational modification] 1191523006029 intermolecular recognition site; other site 1191523006030 dimerization interface [polypeptide binding]; other site 1191523006031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523006032 Walker A motif; other site 1191523006033 ATP binding site [chemical binding]; other site 1191523006034 Walker B motif; other site 1191523006035 arginine finger; other site 1191523006036 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523006037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1191523006038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191523006039 motif II; other site 1191523006040 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1191523006041 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1191523006042 Trp docking motif [polypeptide binding]; other site 1191523006043 active site 1191523006044 PQQ-like domain; Region: PQQ_2; pfam13360 1191523006045 GTP-binding protein LepA; Provisional; Region: PRK05433 1191523006046 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1191523006047 G1 box; other site 1191523006048 putative GEF interaction site [polypeptide binding]; other site 1191523006049 GTP/Mg2+ binding site [chemical binding]; other site 1191523006050 Switch I region; other site 1191523006051 G2 box; other site 1191523006052 G3 box; other site 1191523006053 Switch II region; other site 1191523006054 G4 box; other site 1191523006055 G5 box; other site 1191523006056 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1191523006057 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1191523006058 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1191523006059 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1191523006060 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1191523006061 Catalytic site [active] 1191523006062 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1191523006063 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1191523006064 active site 1191523006065 catalytic residues [active] 1191523006066 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006067 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1191523006068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006069 S-adenosylmethionine binding site [chemical binding]; other site 1191523006070 Rrf2 family protein; Region: rrf2_super; TIGR00738 1191523006071 Transcriptional regulator; Region: Rrf2; pfam02082 1191523006072 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1191523006073 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1191523006074 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1191523006075 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1191523006076 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191523006077 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191523006078 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1191523006079 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1191523006080 homopentamer interface [polypeptide binding]; other site 1191523006081 active site 1191523006082 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1191523006083 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1191523006084 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1191523006085 dimerization interface [polypeptide binding]; other site 1191523006086 active site 1191523006087 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1191523006088 Lumazine binding domain; Region: Lum_binding; pfam00677 1191523006089 Lumazine binding domain; Region: Lum_binding; pfam00677 1191523006090 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1191523006091 catalytic motif [active] 1191523006092 Zn binding site [ion binding]; other site 1191523006093 hypothetical protein; Provisional; Region: PRK04164 1191523006094 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1191523006095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006096 S-adenosylmethionine binding site [chemical binding]; other site 1191523006097 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1191523006098 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1191523006099 peptide chain release factor 2; Provisional; Region: PRK05589 1191523006100 PCRF domain; Region: PCRF; pfam03462 1191523006101 RF-1 domain; Region: RF-1; pfam00472 1191523006102 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1191523006103 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191523006104 ligand binding site [chemical binding]; other site 1191523006105 flexible hinge region; other site 1191523006106 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1191523006107 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1191523006108 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1191523006109 DNA binding site [nucleotide binding] 1191523006110 active site 1191523006111 PspC domain; Region: PspC; pfam04024 1191523006112 NAD synthetase; Provisional; Region: PRK13981 1191523006113 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1191523006114 multimer interface [polypeptide binding]; other site 1191523006115 active site 1191523006116 catalytic triad [active] 1191523006117 protein interface 1 [polypeptide binding]; other site 1191523006118 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1191523006119 homodimer interface [polypeptide binding]; other site 1191523006120 NAD binding pocket [chemical binding]; other site 1191523006121 ATP binding pocket [chemical binding]; other site 1191523006122 Mg binding site [ion binding]; other site 1191523006123 active-site loop [active] 1191523006124 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1191523006125 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1191523006126 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1191523006127 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191523006128 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191523006129 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191523006130 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1191523006131 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1191523006132 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1191523006133 dimer interface [polypeptide binding]; other site 1191523006134 PYR/PP interface [polypeptide binding]; other site 1191523006135 TPP binding site [chemical binding]; other site 1191523006136 substrate binding site [chemical binding]; other site 1191523006137 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1191523006138 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1191523006139 TPP-binding site [chemical binding]; other site 1191523006140 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1191523006141 DHH family; Region: DHH; pfam01368 1191523006142 DHHA1 domain; Region: DHHA1; pfam02272 1191523006143 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1191523006144 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1191523006145 interface (dimer of trimers) [polypeptide binding]; other site 1191523006146 Substrate-binding/catalytic site; other site 1191523006147 Zn-binding sites [ion binding]; other site 1191523006148 Dodecin; Region: Dodecin; pfam07311 1191523006149 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1191523006150 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1191523006151 dimer interface [polypeptide binding]; other site 1191523006152 catalytic triad [active] 1191523006153 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1191523006154 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1191523006155 catalytic triad [active] 1191523006156 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1191523006157 active site 1191523006158 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1191523006159 homodecamer interface [polypeptide binding]; other site 1191523006160 GTP cyclohydrolase I; Provisional; Region: PLN03044 1191523006161 active site 1191523006162 putative catalytic site residues [active] 1191523006163 zinc binding site [ion binding]; other site 1191523006164 GTP-CH-I/GFRP interaction surface; other site 1191523006165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523006166 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1191523006167 NAD(P) binding site [chemical binding]; other site 1191523006168 active site 1191523006169 short chain dehydrogenase; Provisional; Region: PRK07326 1191523006170 classical (c) SDRs; Region: SDR_c; cd05233 1191523006171 NAD(P) binding site [chemical binding]; other site 1191523006172 active site 1191523006173 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1191523006174 dimer interface [polypeptide binding]; other site 1191523006175 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1191523006176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523006177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523006178 DNA binding residues [nucleotide binding] 1191523006179 TPR repeat; Region: TPR_11; pfam13414 1191523006180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006181 binding surface 1191523006182 TPR motif; other site 1191523006183 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523006184 TPR repeat; Region: TPR_11; pfam13414 1191523006185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006186 binding surface 1191523006187 TPR motif; other site 1191523006188 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1191523006189 Outer membrane lipoprotein; Region: YfiO; pfam13525 1191523006190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006191 binding surface 1191523006192 TPR motif; other site 1191523006193 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523006194 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523006195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006196 TPR motif; other site 1191523006197 binding surface 1191523006198 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523006199 Sporulation related domain; Region: SPOR; pfam05036 1191523006200 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1191523006201 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1191523006202 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1191523006203 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523006204 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 1191523006205 NHL repeat; Region: NHL; pfam01436 1191523006206 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006207 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006208 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006209 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006210 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006211 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006212 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006213 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1191523006214 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1191523006215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006216 TPR motif; other site 1191523006217 binding surface 1191523006218 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523006219 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1191523006220 LexA repressor; Validated; Region: PRK00215 1191523006221 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191523006222 Catalytic site [active] 1191523006223 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1191523006224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191523006225 dimerization interface [polypeptide binding]; other site 1191523006226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006227 PAS domain; Region: PAS_9; pfam13426 1191523006228 putative active site [active] 1191523006229 heme pocket [chemical binding]; other site 1191523006230 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1191523006231 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1191523006232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1191523006233 dimer interface [polypeptide binding]; other site 1191523006234 putative CheW interface [polypeptide binding]; other site 1191523006235 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1191523006236 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1191523006237 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1191523006238 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1191523006239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006240 ATP binding site [chemical binding]; other site 1191523006241 Mg2+ binding site [ion binding]; other site 1191523006242 G-X-G motif; other site 1191523006243 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1191523006244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1191523006245 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1191523006246 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006248 active site 1191523006249 phosphorylation site [posttranslational modification] 1191523006250 intermolecular recognition site; other site 1191523006251 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006253 active site 1191523006254 phosphorylation site [posttranslational modification] 1191523006255 intermolecular recognition site; other site 1191523006256 dimerization interface [polypeptide binding]; other site 1191523006257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006259 dimer interface [polypeptide binding]; other site 1191523006260 phosphorylation site [posttranslational modification] 1191523006261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006262 ATP binding site [chemical binding]; other site 1191523006263 Mg2+ binding site [ion binding]; other site 1191523006264 G-X-G motif; other site 1191523006265 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1191523006266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006267 ATP binding site [chemical binding]; other site 1191523006268 Mg2+ binding site [ion binding]; other site 1191523006269 G-X-G motif; other site 1191523006270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006271 dimer interface [polypeptide binding]; other site 1191523006272 phosphorylation site [posttranslational modification] 1191523006273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006274 ATP binding site [chemical binding]; other site 1191523006275 Mg2+ binding site [ion binding]; other site 1191523006276 G-X-G motif; other site 1191523006277 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006279 active site 1191523006280 phosphorylation site [posttranslational modification] 1191523006281 intermolecular recognition site; other site 1191523006282 dimerization interface [polypeptide binding]; other site 1191523006283 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006285 active site 1191523006286 phosphorylation site [posttranslational modification] 1191523006287 intermolecular recognition site; other site 1191523006288 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006290 active site 1191523006291 phosphorylation site [posttranslational modification] 1191523006292 intermolecular recognition site; other site 1191523006293 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006295 active site 1191523006296 phosphorylation site [posttranslational modification] 1191523006297 intermolecular recognition site; other site 1191523006298 dimerization interface [polypeptide binding]; other site 1191523006299 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006301 active site 1191523006302 phosphorylation site [posttranslational modification] 1191523006303 intermolecular recognition site; other site 1191523006304 PAS domain S-box; Region: sensory_box; TIGR00229 1191523006305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1191523006306 putative active site [active] 1191523006307 heme pocket [chemical binding]; other site 1191523006308 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523006309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006310 putative active site [active] 1191523006311 heme pocket [chemical binding]; other site 1191523006312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006313 dimer interface [polypeptide binding]; other site 1191523006314 phosphorylation site [posttranslational modification] 1191523006315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006316 ATP binding site [chemical binding]; other site 1191523006317 G-X-G motif; other site 1191523006318 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1191523006319 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1191523006320 homodimer interface [polypeptide binding]; other site 1191523006321 substrate-cofactor binding pocket; other site 1191523006322 catalytic residue [active] 1191523006323 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191523006324 Ligand Binding Site [chemical binding]; other site 1191523006325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191523006326 Ligand Binding Site [chemical binding]; other site 1191523006327 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1191523006328 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1191523006329 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191523006330 active site 1191523006331 phosphorylation site [posttranslational modification] 1191523006332 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1191523006333 Permease; Region: Permease; pfam02405 1191523006334 glutamate dehydrogenase; Provisional; Region: PRK09414 1191523006335 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1191523006336 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1191523006337 NAD(P) binding site [chemical binding]; other site 1191523006338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006340 phosphorylation site [posttranslational modification] 1191523006341 intermolecular recognition site; other site 1191523006342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1191523006343 active site 1191523006344 dimerization interface [polypeptide binding]; other site 1191523006345 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191523006346 aminotransferase AlaT; Validated; Region: PRK09265 1191523006347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191523006348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523006349 homodimer interface [polypeptide binding]; other site 1191523006350 catalytic residue [active] 1191523006351 xylose isomerase; Provisional; Region: PRK05474 1191523006352 xylose isomerase; Region: xylose_isom_A; TIGR02630 1191523006353 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191523006354 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191523006355 nucleotide binding site [chemical binding]; other site 1191523006356 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1191523006357 nudix motif; other site 1191523006358 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1191523006359 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191523006360 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191523006361 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191523006362 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1191523006363 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191523006364 catalytic loop [active] 1191523006365 iron binding site [ion binding]; other site 1191523006366 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1191523006367 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191523006368 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191523006369 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1191523006370 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1191523006371 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1191523006372 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523006373 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1191523006374 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1191523006375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523006376 Walker A motif; other site 1191523006377 ATP binding site [chemical binding]; other site 1191523006378 Walker B motif; other site 1191523006379 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1191523006380 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523006381 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523006382 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191523006383 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191523006384 Ion transport protein; Region: Ion_trans; pfam00520 1191523006385 Ion channel; Region: Ion_trans_2; pfam07885 1191523006386 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1191523006387 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1191523006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1191523006389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523006390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006391 intermolecular recognition site; other site 1191523006392 active site 1191523006393 dimerization interface [polypeptide binding]; other site 1191523006394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191523006395 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1191523006396 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1191523006397 SelR domain; Region: SelR; pfam01641 1191523006398 Pirin-related protein [General function prediction only]; Region: COG1741 1191523006399 Pirin; Region: Pirin; pfam02678 1191523006400 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1191523006401 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1191523006402 Switch I region; other site 1191523006403 G2 box; other site 1191523006404 Switch II region; other site 1191523006405 G3 box; other site 1191523006406 G4 box; other site 1191523006407 G5 box; other site 1191523006408 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1191523006409 Aspartase; Region: Aspartase; cd01357 1191523006410 active sites [active] 1191523006411 tetramer interface [polypeptide binding]; other site 1191523006412 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1191523006413 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006414 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1191523006415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523006416 active site 1191523006417 HIGH motif; other site 1191523006418 nucleotide binding site [chemical binding]; other site 1191523006419 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1191523006420 KMSKS motif; other site 1191523006421 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1191523006422 anticodon binding site; other site 1191523006423 tRNA binding surface [nucleotide binding]; other site 1191523006424 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1191523006425 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1191523006426 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191523006427 GTPase RsgA; Reviewed; Region: PRK00098 1191523006428 RNA binding site [nucleotide binding]; other site 1191523006429 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1191523006430 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1191523006431 GTP/Mg2+ binding site [chemical binding]; other site 1191523006432 G4 box; other site 1191523006433 G5 box; other site 1191523006434 G1 box; other site 1191523006435 Switch I region; other site 1191523006436 G2 box; other site 1191523006437 G3 box; other site 1191523006438 Switch II region; other site 1191523006439 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523006440 TPR repeat; Region: TPR_11; pfam13414 1191523006441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006442 TPR motif; other site 1191523006443 binding surface 1191523006444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1191523006445 TPR motif; other site 1191523006446 binding surface 1191523006447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006448 TPR motif; other site 1191523006449 binding surface 1191523006450 TPR repeat; Region: TPR_11; pfam13414 1191523006451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006452 binding surface 1191523006453 TPR motif; other site 1191523006454 TPR repeat; Region: TPR_11; pfam13414 1191523006455 TPR repeat; Region: TPR_11; pfam13414 1191523006456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006457 binding surface 1191523006458 TPR motif; other site 1191523006459 TPR repeat; Region: TPR_11; pfam13414 1191523006460 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1191523006461 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1191523006462 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191523006463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523006464 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191523006465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523006466 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191523006467 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1191523006468 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1191523006469 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1191523006470 active site 1191523006471 dimerization interface [polypeptide binding]; other site 1191523006472 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1191523006473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006474 S-adenosylmethionine binding site [chemical binding]; other site 1191523006475 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1191523006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006477 S-adenosylmethionine binding site [chemical binding]; other site 1191523006478 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523006479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523006480 active site 1191523006481 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1191523006482 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1191523006483 Peptidase family M50; Region: Peptidase_M50; pfam02163 1191523006484 active site 1191523006485 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1191523006486 putative substrate binding region [chemical binding]; other site 1191523006487 BNR repeat-like domain; Region: BNR_2; pfam13088 1191523006488 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523006489 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 1191523006490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1191523006491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523006492 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1191523006493 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523006494 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523006495 putative active site [active] 1191523006496 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1191523006497 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191523006498 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191523006499 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191523006500 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191523006501 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523006502 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523006503 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523006504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523006505 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006506 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006507 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523006508 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523006509 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523006510 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1191523006511 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1191523006512 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006513 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1191523006514 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006515 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191523006516 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1191523006517 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191523006518 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1191523006519 active site 1191523006520 catalytic triad [active] 1191523006521 oxyanion hole [active] 1191523006522 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1191523006523 metal binding site [ion binding]; metal-binding site 1191523006524 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1191523006526 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1191523006527 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191523006528 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1191523006529 active site 1191523006530 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191523006531 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1191523006532 active site 1191523006533 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1191523006534 ligand binding site [chemical binding]; other site 1191523006535 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523006536 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006537 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523006538 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523006539 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1191523006540 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1191523006541 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1191523006542 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 1191523006543 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006544 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1191523006545 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191523006546 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1191523006547 inhibitor binding site; inhibition site 1191523006548 active site 1191523006549 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1191523006550 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 1191523006551 B12 binding site [chemical binding]; other site 1191523006552 cobalt ligand [ion binding]; other site 1191523006553 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1191523006554 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1191523006555 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1191523006556 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1191523006557 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1191523006558 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1191523006559 putative active site [active] 1191523006560 putative metal binding site [ion binding]; other site 1191523006561 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523006562 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 1191523006563 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1191523006564 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1191523006565 active site 1191523006566 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1191523006567 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 1191523006568 catalytic domain interface [polypeptide binding]; other site 1191523006569 putative homodimer interface [polypeptide binding]; other site 1191523006570 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191523006571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523006572 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 1191523006573 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1191523006574 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1191523006575 Two component regulator propeller; Region: Reg_prop; pfam07494 1191523006576 Two component regulator propeller; Region: Reg_prop; pfam07494 1191523006577 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1191523006578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006580 dimer interface [polypeptide binding]; other site 1191523006581 phosphorylation site [posttranslational modification] 1191523006582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006583 ATP binding site [chemical binding]; other site 1191523006584 Mg2+ binding site [ion binding]; other site 1191523006585 G-X-G motif; other site 1191523006586 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1191523006587 catalytic residues [active] 1191523006588 dimer interface [polypeptide binding]; other site 1191523006589 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1191523006590 putative metal binding site [ion binding]; other site 1191523006591 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1191523006592 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1191523006593 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1191523006594 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1191523006595 active site 1191523006596 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1191523006597 TSCPD domain; Region: TSCPD; pfam12637 1191523006598 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1191523006599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191523006600 catalytic residue [active] 1191523006601 DivIVA protein; Region: DivIVA; pfam05103 1191523006602 DivIVA domain; Region: DivI1A_domain; TIGR03544 1191523006603 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1191523006604 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1191523006605 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1191523006606 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523006607 active site 1191523006608 HIGH motif; other site 1191523006609 nucleotide binding site [chemical binding]; other site 1191523006610 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1191523006611 active site 1191523006612 KMSKS motif; other site 1191523006613 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1191523006614 tRNA binding surface [nucleotide binding]; other site 1191523006615 anticodon binding site; other site 1191523006616 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1191523006617 lipoprotein signal peptidase; Provisional; Region: PRK14787 1191523006618 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1191523006619 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1191523006620 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191523006621 active site 1191523006622 PAS domain; Region: PAS_8; pfam13188 1191523006623 PAS domain S-box; Region: sensory_box; TIGR00229 1191523006624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006625 PAS domain; Region: PAS_9; pfam13426 1191523006626 putative active site [active] 1191523006627 heme pocket [chemical binding]; other site 1191523006628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006630 dimer interface [polypeptide binding]; other site 1191523006631 phosphorylation site [posttranslational modification] 1191523006632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006633 ATP binding site [chemical binding]; other site 1191523006634 Mg2+ binding site [ion binding]; other site 1191523006635 G-X-G motif; other site 1191523006636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006638 active site 1191523006639 phosphorylation site [posttranslational modification] 1191523006640 intermolecular recognition site; other site 1191523006641 dimerization interface [polypeptide binding]; other site 1191523006642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006644 dimer interface [polypeptide binding]; other site 1191523006645 phosphorylation site [posttranslational modification] 1191523006646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006647 ATP binding site [chemical binding]; other site 1191523006648 Mg2+ binding site [ion binding]; other site 1191523006649 G-X-G motif; other site 1191523006650 HEAT repeats; Region: HEAT_2; pfam13646 1191523006651 HEAT repeats; Region: HEAT_2; pfam13646 1191523006652 HEAT repeats; Region: HEAT_2; pfam13646 1191523006653 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1191523006654 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1191523006655 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1191523006656 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006658 active site 1191523006659 phosphorylation site [posttranslational modification] 1191523006660 intermolecular recognition site; other site 1191523006661 dimerization interface [polypeptide binding]; other site 1191523006662 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1191523006663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006664 active site 1191523006665 phosphorylation site [posttranslational modification] 1191523006666 intermolecular recognition site; other site 1191523006667 dimerization interface [polypeptide binding]; other site 1191523006668 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1191523006669 putative binding surface; other site 1191523006670 active site 1191523006671 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1191523006672 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1191523006673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006674 ATP binding site [chemical binding]; other site 1191523006675 Mg2+ binding site [ion binding]; other site 1191523006676 G-X-G motif; other site 1191523006677 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1191523006678 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1191523006679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006680 active site 1191523006681 phosphorylation site [posttranslational modification] 1191523006682 intermolecular recognition site; other site 1191523006683 CheB methylesterase; Region: CheB_methylest; pfam01339 1191523006684 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 1191523006685 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1191523006686 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1191523006687 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1191523006688 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1191523006689 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1191523006690 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1191523006691 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1191523006692 FliG C-terminal domain; Region: FliG_C; pfam01706 1191523006693 Flagellar assembly protein FliH; Region: FliH; pfam02108 1191523006694 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 1191523006695 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1191523006696 Walker A motif/ATP binding site; other site 1191523006697 Walker B motif; other site 1191523006698 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1191523006699 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 1191523006700 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1191523006701 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523006702 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1191523006703 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1191523006704 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 1191523006705 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1191523006706 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1191523006707 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1191523006708 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1191523006709 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1191523006710 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1191523006711 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1191523006712 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1191523006713 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1191523006714 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1191523006715 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1191523006716 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1191523006717 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1191523006718 FHIPEP family; Region: FHIPEP; pfam00771 1191523006719 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1191523006720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191523006721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191523006722 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1191523006723 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1191523006724 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1191523006725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523006726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523006727 DNA binding residues [nucleotide binding] 1191523006728 HDOD domain; Region: HDOD; pfam08668 1191523006729 HD domain; Region: HD; pfam01966 1191523006730 HDOD domain; Region: HDOD; pfam08668 1191523006731 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523006732 Zn2+ binding site [ion binding]; other site 1191523006733 Mg2+ binding site [ion binding]; other site 1191523006734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006735 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1191523006736 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1191523006737 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1191523006738 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1191523006739 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1191523006740 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1191523006741 SAF-like; Region: SAF_2; pfam13144 1191523006742 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1191523006743 Flagellar L-ring protein; Region: FlgH; pfam02107 1191523006744 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1191523006745 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1191523006746 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1191523006747 Rod binding protein; Region: Rod-binding; cl01626 1191523006748 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1191523006749 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191523006750 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191523006751 catalytic residue [active] 1191523006752 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1191523006753 type II restriction endonuclease, Alw26I/Eco31I/Esp3I family; Region: restrict_Alw26I; TIGR02986 1191523006754 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1191523006755 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1191523006756 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1191523006757 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1191523006758 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1191523006759 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191523006760 ligand binding site [chemical binding]; other site 1191523006761 FliW protein; Region: FliW; cl00740 1191523006762 Global regulator protein family; Region: CsrA; pfam02599 1191523006763 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006765 active site 1191523006766 phosphorylation site [posttranslational modification] 1191523006767 intermolecular recognition site; other site 1191523006768 Hpt domain; Region: Hpt; pfam01627 1191523006769 putative binding surface; other site 1191523006770 active site 1191523006771 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1191523006772 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1191523006773 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1191523006774 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191523006775 ligand binding site [chemical binding]; other site 1191523006776 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006778 active site 1191523006779 phosphorylation site [posttranslational modification] 1191523006780 intermolecular recognition site; other site 1191523006781 dimerization interface [polypeptide binding]; other site 1191523006782 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523006783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006784 active site 1191523006785 phosphorylation site [posttranslational modification] 1191523006786 intermolecular recognition site; other site 1191523006787 dimerization interface [polypeptide binding]; other site 1191523006788 PAS domain; Region: PAS_9; pfam13426 1191523006789 PAS domain; Region: PAS_9; pfam13426 1191523006790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006792 dimer interface [polypeptide binding]; other site 1191523006793 phosphorylation site [posttranslational modification] 1191523006794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006795 ATP binding site [chemical binding]; other site 1191523006796 Mg2+ binding site [ion binding]; other site 1191523006797 G-X-G motif; other site 1191523006798 YtxH-like protein; Region: YtxH; cl02079 1191523006799 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1191523006800 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1191523006801 active site 1191523006802 homodimer interface [polypeptide binding]; other site 1191523006803 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523006804 extended (e) SDRs; Region: SDR_e; cd08946 1191523006805 NAD(P) binding site [chemical binding]; other site 1191523006806 active site 1191523006807 substrate binding site [chemical binding]; other site 1191523006808 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1191523006809 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1191523006810 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1191523006811 NADP binding site [chemical binding]; other site 1191523006812 active site 1191523006813 putative substrate binding site [chemical binding]; other site 1191523006814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006815 S-adenosylmethionine binding site [chemical binding]; other site 1191523006816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006817 binding surface 1191523006818 TPR motif; other site 1191523006819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523006820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1191523006821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006822 binding surface 1191523006823 TPR motif; other site 1191523006824 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523006825 TPR repeat; Region: TPR_11; pfam13414 1191523006826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006827 binding surface 1191523006828 TPR motif; other site 1191523006829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523006830 S-adenosylmethionine binding site [chemical binding]; other site 1191523006831 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523006832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191523006833 active site 1191523006834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523006835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523006836 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523006837 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1191523006838 Probable Catalytic site; other site 1191523006839 metal-binding site 1191523006840 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523006841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006842 TPR motif; other site 1191523006843 binding surface 1191523006844 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1191523006845 putative metal binding site; other site 1191523006846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006847 binding surface 1191523006848 TPR motif; other site 1191523006849 TPR repeat; Region: TPR_11; pfam13414 1191523006850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523006851 TPR motif; other site 1191523006852 binding surface 1191523006853 flagellin; Provisional; Region: PRK12802 1191523006854 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1191523006855 Flagellar protein FliS; Region: FliS; cl00654 1191523006856 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1191523006857 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1191523006858 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006860 active site 1191523006861 phosphorylation site [posttranslational modification] 1191523006862 intermolecular recognition site; other site 1191523006863 dimerization interface [polypeptide binding]; other site 1191523006864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006865 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523006866 putative active site [active] 1191523006867 heme pocket [chemical binding]; other site 1191523006868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006869 dimer interface [polypeptide binding]; other site 1191523006870 phosphorylation site [posttranslational modification] 1191523006871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006872 ATP binding site [chemical binding]; other site 1191523006873 Mg2+ binding site [ion binding]; other site 1191523006874 G-X-G motif; other site 1191523006875 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523006876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006877 active site 1191523006878 phosphorylation site [posttranslational modification] 1191523006879 intermolecular recognition site; other site 1191523006880 dimerization interface [polypeptide binding]; other site 1191523006881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006882 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523006883 putative active site [active] 1191523006884 heme pocket [chemical binding]; other site 1191523006885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006886 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523006887 putative active site [active] 1191523006888 heme pocket [chemical binding]; other site 1191523006889 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523006890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006891 putative active site [active] 1191523006892 heme pocket [chemical binding]; other site 1191523006893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006894 dimer interface [polypeptide binding]; other site 1191523006895 phosphorylation site [posttranslational modification] 1191523006896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006897 ATP binding site [chemical binding]; other site 1191523006898 Mg2+ binding site [ion binding]; other site 1191523006899 G-X-G motif; other site 1191523006900 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1191523006901 putative CheA interaction surface; other site 1191523006902 Hemerythrin; Region: Hemerythrin; cd12107 1191523006903 Fe binding site [ion binding]; other site 1191523006904 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523006905 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1191523006906 HAMP domain; Region: HAMP; pfam00672 1191523006907 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1191523006908 dimerization interface [polypeptide binding]; other site 1191523006909 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1191523006910 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1191523006911 dimer interface [polypeptide binding]; other site 1191523006912 putative CheW interface [polypeptide binding]; other site 1191523006913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523006914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523006915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191523006916 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1191523006917 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1191523006918 G1 box; other site 1191523006919 putative GEF interaction site [polypeptide binding]; other site 1191523006920 GTP/Mg2+ binding site [chemical binding]; other site 1191523006921 Switch I region; other site 1191523006922 G2 box; other site 1191523006923 G3 box; other site 1191523006924 Switch II region; other site 1191523006925 G4 box; other site 1191523006926 G5 box; other site 1191523006927 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1191523006928 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1191523006929 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191523006930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006931 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523006932 putative active site [active] 1191523006933 heme pocket [chemical binding]; other site 1191523006934 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1191523006935 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1191523006936 PAS domain; Region: PAS; smart00091 1191523006937 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523006938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006939 putative active site [active] 1191523006940 heme pocket [chemical binding]; other site 1191523006941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006942 dimer interface [polypeptide binding]; other site 1191523006943 phosphorylation site [posttranslational modification] 1191523006944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006945 ATP binding site [chemical binding]; other site 1191523006946 Mg2+ binding site [ion binding]; other site 1191523006947 G-X-G motif; other site 1191523006948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523006950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523006951 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 1191523006952 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1191523006953 active site 1191523006954 catalytic site [active] 1191523006955 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1191523006956 Protein of unknown function DUF45; Region: DUF45; pfam01863 1191523006957 putative acyltransferase; Provisional; Region: PRK05790 1191523006958 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191523006959 dimer interface [polypeptide binding]; other site 1191523006960 active site 1191523006961 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191523006962 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1191523006963 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1191523006964 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191523006965 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1191523006966 GIY-YIG motif/motif A; other site 1191523006967 putative active site [active] 1191523006968 putative metal binding site [ion binding]; other site 1191523006969 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1191523006970 GIY-YIG motif/motif A; other site 1191523006971 putative active site [active] 1191523006972 putative metal binding site [ion binding]; other site 1191523006973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523006974 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1191523006975 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523006976 N-terminal plug; other site 1191523006977 ligand-binding site [chemical binding]; other site 1191523006978 acetyl-CoA synthetase; Provisional; Region: PRK00174 1191523006979 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1191523006980 active site 1191523006981 CoA binding site [chemical binding]; other site 1191523006982 acyl-activating enzyme (AAE) consensus motif; other site 1191523006983 AMP binding site [chemical binding]; other site 1191523006984 acetate binding site [chemical binding]; other site 1191523006985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523006986 PAS fold; Region: PAS_3; pfam08447 1191523006987 putative active site [active] 1191523006988 heme pocket [chemical binding]; other site 1191523006989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523006990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523006991 dimer interface [polypeptide binding]; other site 1191523006992 phosphorylation site [posttranslational modification] 1191523006993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523006994 ATP binding site [chemical binding]; other site 1191523006995 Mg2+ binding site [ion binding]; other site 1191523006996 G-X-G motif; other site 1191523006997 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523006998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523006999 active site 1191523007000 phosphorylation site [posttranslational modification] 1191523007001 intermolecular recognition site; other site 1191523007002 dimerization interface [polypeptide binding]; other site 1191523007003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007004 Walker A motif; other site 1191523007005 ATP binding site [chemical binding]; other site 1191523007006 Walker B motif; other site 1191523007007 arginine finger; other site 1191523007008 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523007009 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523007010 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1191523007011 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 1191523007012 PEGA domain; Region: PEGA; pfam08308 1191523007013 PEGA domain; Region: PEGA; pfam08308 1191523007014 citrate lyase, alpha subunit; Region: citF; TIGR01584 1191523007015 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1191523007016 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1191523007017 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1191523007018 homoaconitase; Region: h_aconitase; TIGR00139 1191523007019 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1191523007020 substrate binding site [chemical binding]; other site 1191523007021 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1191523007022 ligand binding site [chemical binding]; other site 1191523007023 Homoaconitase swivel domain. This family includes homoaconitase and other uncharacterized proteins of the Aconitase family. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized...; Region: Homoaconitase_Swivel; cd01674 1191523007024 substrate binding site [chemical binding]; other site 1191523007025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523007026 Zn2+ binding site [ion binding]; other site 1191523007027 Mg2+ binding site [ion binding]; other site 1191523007028 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1191523007029 Carbon starvation protein CstA; Region: CstA; pfam02554 1191523007030 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1191523007031 tartrate dehydrogenase; Region: TTC; TIGR02089 1191523007032 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1191523007033 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1191523007034 active site 1191523007035 hydrophilic channel; other site 1191523007036 dimerization interface [polypeptide binding]; other site 1191523007037 catalytic residues [active] 1191523007038 active site lid [active] 1191523007039 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 1191523007040 OPT oligopeptide transporter protein; Region: OPT; cl14607 1191523007041 putative oligopeptide transporter, OPT family; Region: TIGR00733 1191523007042 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1191523007043 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1191523007044 metal binding site [ion binding]; metal-binding site 1191523007045 dimer interface [polypeptide binding]; other site 1191523007046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523007047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523007048 putative substrate translocation pore; other site 1191523007049 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1191523007050 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1191523007051 Part of AAA domain; Region: AAA_19; pfam13245 1191523007052 Family description; Region: UvrD_C_2; pfam13538 1191523007053 6-phosphofructokinase; Provisional; Region: PRK03202 1191523007054 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1191523007055 active site 1191523007056 ADP/pyrophosphate binding site [chemical binding]; other site 1191523007057 dimerization interface [polypeptide binding]; other site 1191523007058 allosteric effector site; other site 1191523007059 fructose-1,6-bisphosphate binding site; other site 1191523007060 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1191523007061 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1191523007062 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1191523007063 Na2 binding site [ion binding]; other site 1191523007064 putative substrate binding site 1 [chemical binding]; other site 1191523007065 Na binding site 1 [ion binding]; other site 1191523007066 putative substrate binding site 2 [chemical binding]; other site 1191523007067 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1191523007068 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1191523007069 putative NAD(P) binding site [chemical binding]; other site 1191523007070 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007071 Interdomain contacts; other site 1191523007072 Cytokine receptor motif; other site 1191523007073 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523007074 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007075 Interdomain contacts; other site 1191523007076 Cytokine receptor motif; other site 1191523007077 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523007078 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191523007079 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1191523007080 active site 1191523007081 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1191523007082 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1191523007083 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1191523007084 Predicted ATPases involved in biogenesis of archaeal flagella [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlaH; COG2874 1191523007085 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1191523007086 Walker A motif; other site 1191523007087 ATP binding site [chemical binding]; other site 1191523007088 Walker B motif; other site 1191523007089 TPR repeat; Region: TPR_11; pfam13414 1191523007090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523007091 binding surface 1191523007092 TPR motif; other site 1191523007093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523007094 binding surface 1191523007095 TPR motif; other site 1191523007096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523007097 binding surface 1191523007098 TPR motif; other site 1191523007099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523007100 binding surface 1191523007101 TPR motif; other site 1191523007102 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1191523007103 active site 1191523007104 oxyanion hole [active] 1191523007105 catalytic triad [active] 1191523007106 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191523007107 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1191523007108 DXD motif; other site 1191523007109 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1191523007110 conserved cys residue [active] 1191523007111 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1191523007112 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007113 Interdomain contacts; other site 1191523007114 Cytokine receptor motif; other site 1191523007115 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007116 Interdomain contacts; other site 1191523007117 Cytokine receptor motif; other site 1191523007118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523007119 PAS fold; Region: PAS_4; pfam08448 1191523007120 putative active site [active] 1191523007121 heme pocket [chemical binding]; other site 1191523007122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523007123 putative active site [active] 1191523007124 heme pocket [chemical binding]; other site 1191523007125 PAS fold; Region: PAS; pfam00989 1191523007126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523007127 putative active site [active] 1191523007128 heme pocket [chemical binding]; other site 1191523007129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523007130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007131 dimer interface [polypeptide binding]; other site 1191523007132 phosphorylation site [posttranslational modification] 1191523007133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007134 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007135 active site 1191523007136 phosphorylation site [posttranslational modification] 1191523007137 intermolecular recognition site; other site 1191523007138 dimerization interface [polypeptide binding]; other site 1191523007139 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1191523007140 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1191523007141 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1191523007142 DNA binding site [nucleotide binding] 1191523007143 active site 1191523007144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523007145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523007146 putative substrate translocation pore; other site 1191523007147 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1191523007148 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1191523007149 inhibitor-cofactor binding pocket; inhibition site 1191523007150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523007151 catalytic residue [active] 1191523007152 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1191523007153 active site 1191523007154 substrate binding site [chemical binding]; other site 1191523007155 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1191523007156 metal binding site [ion binding]; metal-binding site 1191523007157 PAS fold; Region: PAS_4; pfam08448 1191523007158 PAS domain S-box; Region: sensory_box; TIGR00229 1191523007159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523007160 putative active site [active] 1191523007161 heme pocket [chemical binding]; other site 1191523007162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523007163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007164 dimer interface [polypeptide binding]; other site 1191523007165 phosphorylation site [posttranslational modification] 1191523007166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523007167 ATP binding site [chemical binding]; other site 1191523007168 Mg2+ binding site [ion binding]; other site 1191523007169 G-X-G motif; other site 1191523007170 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1191523007171 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191523007172 minor groove reading motif; other site 1191523007173 helix-hairpin-helix signature motif; other site 1191523007174 substrate binding pocket [chemical binding]; other site 1191523007175 active site 1191523007176 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1191523007177 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1191523007178 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1191523007179 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1191523007180 TPP-binding site [chemical binding]; other site 1191523007181 tetramer interface [polypeptide binding]; other site 1191523007182 heterodimer interface [polypeptide binding]; other site 1191523007183 phosphorylation loop region [posttranslational modification] 1191523007184 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1191523007185 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1191523007186 alpha subunit interface [polypeptide binding]; other site 1191523007187 TPP binding site [chemical binding]; other site 1191523007188 heterodimer interface [polypeptide binding]; other site 1191523007189 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191523007190 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1191523007191 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191523007192 E3 interaction surface; other site 1191523007193 lipoyl attachment site [posttranslational modification]; other site 1191523007194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191523007195 E3 interaction surface; other site 1191523007196 lipoyl attachment site [posttranslational modification]; other site 1191523007197 e3 binding domain; Region: E3_binding; pfam02817 1191523007198 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1191523007199 lipoyl synthase; Provisional; Region: PRK05481 1191523007200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523007201 FeS/SAM binding site; other site 1191523007202 Ferredoxin [Energy production and conversion]; Region: COG1146 1191523007203 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1191523007204 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1191523007205 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1191523007206 dimer interface [polypeptide binding]; other site 1191523007207 PYR/PP interface [polypeptide binding]; other site 1191523007208 TPP binding site [chemical binding]; other site 1191523007209 substrate binding site [chemical binding]; other site 1191523007210 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1191523007211 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1191523007212 TPP-binding site [chemical binding]; other site 1191523007213 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1191523007214 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1191523007215 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1191523007216 putative hydrophobic ligand binding site [chemical binding]; other site 1191523007217 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1191523007218 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1191523007219 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1191523007220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191523007221 active site 1191523007222 HIGH motif; other site 1191523007223 nucleotide binding site [chemical binding]; other site 1191523007224 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1191523007225 KMSKS motif; other site 1191523007226 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1191523007227 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1191523007228 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1191523007229 active site 1191523007230 HIGH motif; other site 1191523007231 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1191523007232 active site 1191523007233 KMSKS motif; other site 1191523007234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523007235 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1191523007236 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007238 active site 1191523007239 phosphorylation site [posttranslational modification] 1191523007240 intermolecular recognition site; other site 1191523007241 dimerization interface [polypeptide binding]; other site 1191523007242 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1191523007243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007244 active site 1191523007245 phosphorylation site [posttranslational modification] 1191523007246 intermolecular recognition site; other site 1191523007247 dimerization interface [polypeptide binding]; other site 1191523007248 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007250 active site 1191523007251 phosphorylation site [posttranslational modification] 1191523007252 intermolecular recognition site; other site 1191523007253 dimerization interface [polypeptide binding]; other site 1191523007254 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1191523007255 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1191523007256 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523007257 Clp protease; Region: CLP_protease; pfam00574 1191523007258 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1191523007259 oligomer interface [polypeptide binding]; other site 1191523007260 active site residues [active] 1191523007261 trigger factor; Region: tig; TIGR00115 1191523007262 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1191523007263 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1191523007264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1191523007265 active site 1191523007266 ATP binding site [chemical binding]; other site 1191523007267 substrate binding site [chemical binding]; other site 1191523007268 activation loop (A-loop); other site 1191523007269 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1191523007270 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1191523007271 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1191523007272 hinge; other site 1191523007273 active site 1191523007274 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1191523007275 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1191523007276 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1191523007277 active site 1191523007278 NTP binding site [chemical binding]; other site 1191523007279 metal binding triad [ion binding]; metal-binding site 1191523007280 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1191523007281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191523007282 Zn2+ binding site [ion binding]; other site 1191523007283 Mg2+ binding site [ion binding]; other site 1191523007284 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1191523007285 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1191523007286 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191523007287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191523007288 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191523007289 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191523007290 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191523007291 Walker A/P-loop; other site 1191523007292 ATP binding site [chemical binding]; other site 1191523007293 Q-loop/lid; other site 1191523007294 ABC transporter signature motif; other site 1191523007295 Walker B; other site 1191523007296 D-loop; other site 1191523007297 H-loop/switch region; other site 1191523007298 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523007299 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1191523007300 FtsX-like permease family; Region: FtsX; pfam02687 1191523007301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523007302 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1191523007303 FtsX-like permease family; Region: FtsX; pfam02687 1191523007304 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1191523007305 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1191523007306 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1191523007307 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1191523007308 active site 1191523007309 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1191523007310 elongation factor P; Validated; Region: PRK00529 1191523007311 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1191523007312 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1191523007313 RNA binding site [nucleotide binding]; other site 1191523007314 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1191523007315 RNA binding site [nucleotide binding]; other site 1191523007316 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1191523007317 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523007318 carboxyltransferase (CT) interaction site; other site 1191523007319 biotinylation site [posttranslational modification]; other site 1191523007320 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1191523007321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191523007322 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191523007323 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1191523007324 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1191523007325 lipoyl attachment site [posttranslational modification]; other site 1191523007326 GMP synthase; Reviewed; Region: guaA; PRK00074 1191523007327 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1191523007328 AMP/PPi binding site [chemical binding]; other site 1191523007329 candidate oxyanion hole; other site 1191523007330 catalytic triad [active] 1191523007331 potential glutamine specificity residues [chemical binding]; other site 1191523007332 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1191523007333 ATP Binding subdomain [chemical binding]; other site 1191523007334 Ligand Binding sites [chemical binding]; other site 1191523007335 Dimerization subdomain; other site 1191523007336 hypothetical protein; Reviewed; Region: PRK00024 1191523007337 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1191523007338 helix-hairpin-helix signature motif; other site 1191523007339 active site 1191523007340 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1191523007341 MPN+ (JAMM) motif; other site 1191523007342 Zinc-binding site [ion binding]; other site 1191523007343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523007344 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1191523007345 PhoH-like protein; Region: PhoH; pfam02562 1191523007346 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1191523007347 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1191523007348 homodimer interface [polypeptide binding]; other site 1191523007349 metal binding site [ion binding]; metal-binding site 1191523007350 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1191523007351 homodimer interface [polypeptide binding]; other site 1191523007352 active site 1191523007353 putative chemical substrate binding site [chemical binding]; other site 1191523007354 metal binding site [ion binding]; metal-binding site 1191523007355 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1191523007356 homotrimer interaction site [polypeptide binding]; other site 1191523007357 putative active site [active] 1191523007358 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1191523007359 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1191523007360 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1191523007361 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1191523007362 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1191523007363 active site 1191523007364 HIGH motif; other site 1191523007365 KMSK motif region; other site 1191523007366 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1191523007367 tRNA binding surface [nucleotide binding]; other site 1191523007368 anticodon binding site; other site 1191523007369 DNA utilization protein GntX; Provisional; Region: PRK11595 1191523007370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523007371 active site 1191523007372 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1191523007373 CARDB; Region: CARDB; pfam07705 1191523007374 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1191523007375 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1191523007376 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1191523007377 generic binding surface II; other site 1191523007378 generic binding surface I; other site 1191523007379 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1191523007380 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1191523007381 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1191523007382 TPP-binding site; other site 1191523007383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191523007384 PYR/PP interface [polypeptide binding]; other site 1191523007385 dimer interface [polypeptide binding]; other site 1191523007386 TPP binding site [chemical binding]; other site 1191523007387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191523007388 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523007389 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523007390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523007391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007392 active site 1191523007393 phosphorylation site [posttranslational modification] 1191523007394 intermolecular recognition site; other site 1191523007395 dimerization interface [polypeptide binding]; other site 1191523007396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191523007397 DNA binding site [nucleotide binding] 1191523007398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007399 dimer interface [polypeptide binding]; other site 1191523007400 phosphorylation site [posttranslational modification] 1191523007401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523007402 ATP binding site [chemical binding]; other site 1191523007403 Mg2+ binding site [ion binding]; other site 1191523007404 G-X-G motif; other site 1191523007405 Alginate lyase; Region: Alginate_lyase; pfam05426 1191523007406 Alginate lyase; Region: Alginate_lyase; pfam05426 1191523007407 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191523007408 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523007409 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191523007410 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191523007411 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523007412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523007413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523007414 putative transposase OrfB; Reviewed; Region: PHA02517 1191523007415 HTH-like domain; Region: HTH_21; pfam13276 1191523007416 Integrase core domain; Region: rve; pfam00665 1191523007417 Integrase core domain; Region: rve_3; pfam13683 1191523007418 Transposase; Region: HTH_Tnp_1; pfam01527 1191523007419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1191523007420 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 1191523007421 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007422 Interdomain contacts; other site 1191523007423 Cytokine receptor motif; other site 1191523007424 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523007425 Interdomain contacts; other site 1191523007426 Cytokine receptor motif; other site 1191523007427 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1191523007428 sugar binding site [chemical binding]; other site 1191523007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523007430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523007431 putative substrate translocation pore; other site 1191523007432 Glucuronate isomerase; Region: UxaC; pfam02614 1191523007433 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1191523007434 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1191523007435 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1191523007436 active site 1191523007437 intersubunit interface [polypeptide binding]; other site 1191523007438 catalytic residue [active] 1191523007439 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1191523007440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523007441 NAD(P) binding site [chemical binding]; other site 1191523007442 active site 1191523007443 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191523007444 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523007445 substrate binding site [chemical binding]; other site 1191523007446 ATP binding site [chemical binding]; other site 1191523007447 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1191523007448 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1191523007449 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1191523007450 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1191523007451 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1191523007452 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191523007453 TPP-binding site [chemical binding]; other site 1191523007454 dimer interface [polypeptide binding]; other site 1191523007455 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191523007456 PYR/PP interface [polypeptide binding]; other site 1191523007457 dimer interface [polypeptide binding]; other site 1191523007458 TPP binding site [chemical binding]; other site 1191523007459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191523007460 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1191523007461 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1191523007462 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1191523007463 NADP binding site [chemical binding]; other site 1191523007464 homodimer interface [polypeptide binding]; other site 1191523007465 active site 1191523007466 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523007467 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1191523007468 Trehalose utilisation; Region: ThuA; pfam06283 1191523007469 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191523007470 active site 1191523007471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191523007472 catalytic tetrad [active] 1191523007473 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1191523007474 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1191523007475 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523007476 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1191523007477 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1191523007478 Interdomain contacts; other site 1191523007479 Cytokine receptor motif; other site 1191523007480 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1191523007481 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523007482 Pectate lyase; Region: Pec_lyase_C; cl01593 1191523007483 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523007484 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191523007485 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1191523007486 active site 1191523007487 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523007488 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1191523007489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523007490 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523007491 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 1191523007492 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1191523007493 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1191523007494 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1191523007495 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191523007496 Pectic acid lyase; Region: Pec_lyase; pfam09492 1191523007497 putative pectinesterase; Region: PLN02432; cl01911 1191523007498 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 1191523007499 GTP-binding protein YchF; Reviewed; Region: PRK09601 1191523007500 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1191523007501 G1 box; other site 1191523007502 GTP/Mg2+ binding site [chemical binding]; other site 1191523007503 G3 box; other site 1191523007504 Switch II region; other site 1191523007505 G4 box; other site 1191523007506 G5 box; other site 1191523007507 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1191523007508 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1191523007509 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1191523007510 metal binding site [ion binding]; metal-binding site 1191523007511 dimer interface [polypeptide binding]; other site 1191523007512 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1191523007513 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1191523007514 acyl-activating enzyme (AAE) consensus motif; other site 1191523007515 putative AMP binding site [chemical binding]; other site 1191523007516 putative active site [active] 1191523007517 putative CoA binding site [chemical binding]; other site 1191523007518 Sporulation related domain; Region: SPOR; pfam05036 1191523007519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1191523007520 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191523007521 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1191523007522 active site 1191523007523 catalytic site [active] 1191523007524 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 1191523007525 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1191523007526 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1191523007527 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1191523007528 alpha subunit interaction interface [polypeptide binding]; other site 1191523007529 Walker A motif; other site 1191523007530 ATP binding site [chemical binding]; other site 1191523007531 Walker B motif; other site 1191523007532 inhibitor binding site; inhibition site 1191523007533 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1191523007534 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1191523007535 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1191523007536 gamma subunit interface [polypeptide binding]; other site 1191523007537 epsilon subunit interface [polypeptide binding]; other site 1191523007538 LBP interface [polypeptide binding]; other site 1191523007539 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1191523007540 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1191523007541 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1191523007542 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1191523007543 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1191523007544 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1191523007545 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1191523007546 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1191523007547 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1191523007548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523007549 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1191523007550 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523007551 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1191523007552 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1191523007553 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191523007554 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1191523007555 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1191523007556 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1191523007557 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1191523007558 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191523007559 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1191523007560 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1191523007561 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1191523007562 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1191523007563 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1191523007564 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1191523007565 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1191523007566 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1191523007567 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1191523007568 ligand binding site [chemical binding]; other site 1191523007569 homodimer interface [polypeptide binding]; other site 1191523007570 NAD(P) binding site [chemical binding]; other site 1191523007571 trimer interface B [polypeptide binding]; other site 1191523007572 trimer interface A [polypeptide binding]; other site 1191523007573 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1191523007574 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1191523007575 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1191523007576 HEAT repeats; Region: HEAT_2; pfam13646 1191523007577 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523007578 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1191523007579 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191523007580 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1191523007581 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1191523007582 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191523007583 active site 1191523007584 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1191523007585 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1191523007586 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1191523007587 Pleckstrin homology-like domain; Region: PH-like; cl17171 1191523007588 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1191523007589 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1191523007590 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1191523007591 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523007592 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523007593 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1191523007594 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1191523007595 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1191523007596 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191523007597 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1191523007598 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1191523007599 catalytic triad [active] 1191523007600 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1191523007601 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1191523007602 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1191523007603 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191523007604 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1191523007605 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1191523007606 active site 1191523007607 catalytic triad [active] 1191523007608 dimer interface [polypeptide binding]; other site 1191523007609 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1191523007610 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1191523007611 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1191523007612 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1191523007613 dimerization interface [polypeptide binding]; other site 1191523007614 ligand binding site [chemical binding]; other site 1191523007615 NADP binding site [chemical binding]; other site 1191523007616 catalytic site [active] 1191523007617 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1191523007618 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1191523007619 hexamer interface [polypeptide binding]; other site 1191523007620 ligand binding site [chemical binding]; other site 1191523007621 putative active site [active] 1191523007622 NAD(P) binding site [chemical binding]; other site 1191523007623 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1191523007624 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1191523007625 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1191523007626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191523007627 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1191523007628 active site 1191523007629 metal binding site [ion binding]; metal-binding site 1191523007630 cell surface protein SprA; Region: surface_SprA; TIGR04189 1191523007631 Motility related/secretion protein; Region: SprA_N; pfam14349 1191523007632 Motility related/secretion protein; Region: SprA_N; pfam14349 1191523007633 Motility related/secretion protein; Region: SprA_N; pfam14349 1191523007634 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007636 active site 1191523007637 phosphorylation site [posttranslational modification] 1191523007638 intermolecular recognition site; other site 1191523007639 dimerization interface [polypeptide binding]; other site 1191523007640 PglZ domain; Region: PglZ; pfam08665 1191523007641 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1191523007642 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1191523007643 Glycoprotease family; Region: Peptidase_M22; pfam00814 1191523007644 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1191523007645 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1191523007646 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1191523007647 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1191523007648 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1191523007649 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1191523007650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523007651 catalytic residue [active] 1191523007652 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1191523007653 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1191523007654 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1191523007655 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1191523007656 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1191523007657 putative dimer interface [polypeptide binding]; other site 1191523007658 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1191523007659 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1191523007660 nucleotide binding site [chemical binding]; other site 1191523007661 NEF interaction site [polypeptide binding]; other site 1191523007662 SBD interface [polypeptide binding]; other site 1191523007663 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1191523007664 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1191523007665 putative dimer interface [polypeptide binding]; other site 1191523007666 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1191523007667 Zn binding site [ion binding]; other site 1191523007668 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1191523007669 active site 1191523007670 catalytic residues [active] 1191523007671 metal binding site [ion binding]; metal-binding site 1191523007672 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1191523007673 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1191523007674 putative active site [active] 1191523007675 substrate binding site [chemical binding]; other site 1191523007676 putative cosubstrate binding site; other site 1191523007677 catalytic site [active] 1191523007678 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1191523007679 substrate binding site [chemical binding]; other site 1191523007680 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191523007681 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191523007682 dimer interface [polypeptide binding]; other site 1191523007683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523007684 catalytic residue [active] 1191523007685 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1191523007686 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1191523007687 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191523007688 homodimer interface [polypeptide binding]; other site 1191523007689 substrate-cofactor binding pocket; other site 1191523007690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523007691 catalytic residue [active] 1191523007692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1191523007693 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1191523007694 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523007695 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191523007696 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1191523007697 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1191523007698 ATP binding site [chemical binding]; other site 1191523007699 active site 1191523007700 substrate binding site [chemical binding]; other site 1191523007701 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1191523007702 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1191523007703 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1191523007704 tetramer interfaces [polypeptide binding]; other site 1191523007705 binuclear metal-binding site [ion binding]; other site 1191523007706 competence damage-inducible protein A; Provisional; Region: PRK00549 1191523007707 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1191523007708 putative MPT binding site; other site 1191523007709 Competence-damaged protein; Region: CinA; pfam02464 1191523007710 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1191523007711 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1191523007712 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1191523007713 recombinase A; Provisional; Region: recA; PRK09354 1191523007714 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1191523007715 hexamer interface [polypeptide binding]; other site 1191523007716 Walker A motif; other site 1191523007717 ATP binding site [chemical binding]; other site 1191523007718 Walker B motif; other site 1191523007719 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1191523007720 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1191523007721 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191523007722 active site 1191523007723 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1191523007724 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1191523007725 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1191523007726 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1191523007727 active site 1191523007728 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1191523007729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523007730 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1191523007731 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1191523007732 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1191523007733 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1191523007734 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1191523007735 nucleotide binding site/active site [active] 1191523007736 HIT family signature motif; other site 1191523007737 catalytic residue [active] 1191523007738 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1191523007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007740 active site 1191523007741 phosphorylation site [posttranslational modification] 1191523007742 intermolecular recognition site; other site 1191523007743 dimerization interface [polypeptide binding]; other site 1191523007744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007745 Walker A motif; other site 1191523007746 ATP binding site [chemical binding]; other site 1191523007747 Walker B motif; other site 1191523007748 arginine finger; other site 1191523007749 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191523007750 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1191523007751 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1191523007752 Walker A; other site 1191523007753 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1191523007754 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1191523007755 active site 1191523007756 (T/H)XGH motif; other site 1191523007757 Protease prsW family; Region: PrsW-protease; pfam13367 1191523007758 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1191523007759 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1191523007760 putative phosphate acyltransferase; Provisional; Region: PRK05331 1191523007761 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1191523007762 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1191523007763 dimer interface [polypeptide binding]; other site 1191523007764 active site 1191523007765 CoA binding pocket [chemical binding]; other site 1191523007766 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1191523007767 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1191523007768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191523007769 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1191523007770 NAD(P) binding site [chemical binding]; other site 1191523007771 homotetramer interface [polypeptide binding]; other site 1191523007772 homodimer interface [polypeptide binding]; other site 1191523007773 active site 1191523007774 acyl carrier protein; Provisional; Region: acpP; PRK00982 1191523007775 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1191523007776 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191523007777 dimer interface [polypeptide binding]; other site 1191523007778 active site 1191523007779 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1191523007780 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1191523007781 dimerization interface [polypeptide binding]; other site 1191523007782 active site 1191523007783 metal binding site [ion binding]; metal-binding site 1191523007784 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1191523007785 dsRNA binding site [nucleotide binding]; other site 1191523007786 glycine dehydrogenase; Provisional; Region: PRK05367 1191523007787 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1191523007788 tetramer interface [polypeptide binding]; other site 1191523007789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523007790 catalytic residue [active] 1191523007791 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1191523007792 tetramer interface [polypeptide binding]; other site 1191523007793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523007794 catalytic residue [active] 1191523007795 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1191523007796 RNA methyltransferase, RsmE family; Region: TIGR00046 1191523007797 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1191523007798 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1191523007799 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1191523007800 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1191523007801 Nucleoside recognition; Region: Gate; pfam07670 1191523007802 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1191523007803 thymidine kinase; Provisional; Region: PRK04296 1191523007804 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1191523007805 active site 1191523007806 catalytic motif [active] 1191523007807 Zn binding site [ion binding]; other site 1191523007808 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1191523007809 Part of AAA domain; Region: AAA_19; pfam13245 1191523007810 Family description; Region: UvrD_C_2; pfam13538 1191523007811 hypothetical protein; Provisional; Region: PRK13665 1191523007812 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1191523007813 Clp amino terminal domain; Region: Clp_N; pfam02861 1191523007814 Clp amino terminal domain; Region: Clp_N; pfam02861 1191523007815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007816 Walker A motif; other site 1191523007817 ATP binding site [chemical binding]; other site 1191523007818 Walker B motif; other site 1191523007819 arginine finger; other site 1191523007820 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1191523007821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007822 Walker A motif; other site 1191523007823 ATP binding site [chemical binding]; other site 1191523007824 Walker B motif; other site 1191523007825 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1191523007826 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1191523007827 aromatic arch; other site 1191523007828 DCoH dimer interaction site [polypeptide binding]; other site 1191523007829 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1191523007830 DCoH tetramer interaction site [polypeptide binding]; other site 1191523007831 substrate binding site [chemical binding]; other site 1191523007832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523007833 active site 1191523007834 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1191523007835 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1191523007836 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1191523007837 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1191523007838 SLBB domain; Region: SLBB; pfam10531 1191523007839 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1191523007840 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1191523007841 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191523007842 E3 interaction surface; other site 1191523007843 lipoyl attachment site [posttranslational modification]; other site 1191523007844 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1191523007845 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1191523007846 putative hexamer interface [polypeptide binding]; other site 1191523007847 putative hexagonal pore; other site 1191523007848 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1191523007849 putative hexamer interface [polypeptide binding]; other site 1191523007850 putative hexagonal pore; other site 1191523007851 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191523007852 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1191523007853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523007854 NAD(P) binding site [chemical binding]; other site 1191523007855 active site 1191523007856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523007857 binding surface 1191523007858 TPR motif; other site 1191523007859 TPR repeat; Region: TPR_11; pfam13414 1191523007860 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1191523007861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007862 Walker A motif; other site 1191523007863 ATP binding site [chemical binding]; other site 1191523007864 Walker B motif; other site 1191523007865 arginine finger; other site 1191523007866 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191523007867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007868 Walker A motif; other site 1191523007869 ATP binding site [chemical binding]; other site 1191523007870 Walker B motif; other site 1191523007871 arginine finger; other site 1191523007872 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1191523007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191523007874 Walker A motif; other site 1191523007875 ATP binding site [chemical binding]; other site 1191523007876 Walker B motif; other site 1191523007877 arginine finger; other site 1191523007878 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1191523007879 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1191523007880 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1191523007881 putative dimer interface [polypeptide binding]; other site 1191523007882 [2Fe-2S] cluster binding site [ion binding]; other site 1191523007883 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1191523007884 dimer interface [polypeptide binding]; other site 1191523007885 [2Fe-2S] cluster binding site [ion binding]; other site 1191523007886 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1191523007887 SLBB domain; Region: SLBB; pfam10531 1191523007888 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1191523007889 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1191523007890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191523007891 catalytic loop [active] 1191523007892 iron binding site [ion binding]; other site 1191523007893 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1191523007894 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1191523007895 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1191523007896 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1191523007897 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1191523007898 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1191523007899 Putative Fe-S cluster; Region: FeS; cl17515 1191523007900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007901 dimer interface [polypeptide binding]; other site 1191523007902 phosphorylation site [posttranslational modification] 1191523007903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523007904 ATP binding site [chemical binding]; other site 1191523007905 Mg2+ binding site [ion binding]; other site 1191523007906 G-X-G motif; other site 1191523007907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007908 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007909 active site 1191523007910 phosphorylation site [posttranslational modification] 1191523007911 intermolecular recognition site; other site 1191523007912 dimerization interface [polypeptide binding]; other site 1191523007913 Response regulator receiver domain; Region: Response_reg; pfam00072 1191523007914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007915 active site 1191523007916 phosphorylation site [posttranslational modification] 1191523007917 intermolecular recognition site; other site 1191523007918 dimerization interface [polypeptide binding]; other site 1191523007919 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523007920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523007921 putative active site [active] 1191523007922 heme pocket [chemical binding]; other site 1191523007923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007924 dimer interface [polypeptide binding]; other site 1191523007925 phosphorylation site [posttranslational modification] 1191523007926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523007927 ATP binding site [chemical binding]; other site 1191523007928 Mg2+ binding site [ion binding]; other site 1191523007929 G-X-G motif; other site 1191523007930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191523007931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191523007932 active site 1191523007933 phosphorylation site [posttranslational modification] 1191523007934 intermolecular recognition site; other site 1191523007935 dimerization interface [polypeptide binding]; other site 1191523007936 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1191523007937 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1191523007938 putative dimer interface [polypeptide binding]; other site 1191523007939 [2Fe-2S] cluster binding site [ion binding]; other site 1191523007940 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1191523007941 SLBB domain; Region: SLBB; pfam10531 1191523007942 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1191523007943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191523007944 catalytic loop [active] 1191523007945 iron binding site [ion binding]; other site 1191523007946 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1191523007947 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1191523007948 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1191523007949 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1191523007950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191523007951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523007952 dimer interface [polypeptide binding]; other site 1191523007953 phosphorylation site [posttranslational modification] 1191523007954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523007955 ATP binding site [chemical binding]; other site 1191523007956 Mg2+ binding site [ion binding]; other site 1191523007957 G-X-G motif; other site 1191523007958 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 1191523007959 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1191523007960 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1191523007961 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523007962 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523007963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523007964 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523007965 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523007966 putative active site [active] 1191523007967 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191523007968 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191523007969 putative active site [active] 1191523007970 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1191523007971 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1191523007972 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1191523007973 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1191523007974 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1191523007975 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1191523007976 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 1191523007977 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 1191523007978 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 1191523007979 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1191523007980 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1191523007981 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1191523007982 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1191523007983 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1191523007984 substrate binding site [chemical binding]; other site 1191523007985 hexamer interface [polypeptide binding]; other site 1191523007986 metal binding site [ion binding]; metal-binding site 1191523007987 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191523007988 dihydropteroate synthase; Region: DHPS; TIGR01496 1191523007989 substrate binding pocket [chemical binding]; other site 1191523007990 dimer interface [polypeptide binding]; other site 1191523007991 inhibitor binding site; inhibition site 1191523007992 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1191523007993 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1191523007994 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191523007995 metal-dependent hydrolase; Provisional; Region: PRK00685 1191523007996 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1191523007997 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191523007998 P-loop; other site 1191523007999 Magnesium ion binding site [ion binding]; other site 1191523008000 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191523008001 Magnesium ion binding site [ion binding]; other site 1191523008002 ParB-like nuclease domain; Region: ParBc; pfam02195 1191523008003 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1191523008004 KorB domain; Region: KorB; pfam08535 1191523008005 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1191523008006 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1191523008007 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1191523008008 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1191523008009 trimer interface [polypeptide binding]; other site 1191523008010 active site 1191523008011 dimer interface [polypeptide binding]; other site 1191523008012 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1191523008013 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1191523008014 DNA binding residues [nucleotide binding] 1191523008015 HD domain; Region: HD_4; pfam13328 1191523008016 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1191523008017 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1191523008018 active site 1191523008019 tetramer interface [polypeptide binding]; other site 1191523008020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523008021 active site 1191523008022 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1191523008023 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1191523008024 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1191523008025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1191523008026 P loop; other site 1191523008027 GTP binding site [chemical binding]; other site 1191523008028 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1191523008029 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1191523008030 PEGA domain; Region: PEGA; pfam08308 1191523008031 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1191523008032 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1191523008033 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1191523008034 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191523008035 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191523008036 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1191523008037 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1191523008038 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1191523008039 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1191523008040 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1191523008041 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191523008042 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1191523008043 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1191523008044 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1191523008045 Hpr binding site; other site 1191523008046 active site 1191523008047 homohexamer subunit interaction site [polypeptide binding]; other site 1191523008048 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1191523008049 30S subunit binding site; other site 1191523008050 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191523008051 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1191523008052 active site 1191523008053 DNA binding site [nucleotide binding] 1191523008054 Int/Topo IB signature motif; other site 1191523008055 DNA topoisomerase I; Validated; Region: PRK06599 1191523008056 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1191523008057 active site 1191523008058 interdomain interaction site; other site 1191523008059 putative metal-binding site [ion binding]; other site 1191523008060 nucleotide binding site [chemical binding]; other site 1191523008061 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1191523008062 domain I; other site 1191523008063 DNA binding groove [nucleotide binding] 1191523008064 phosphate binding site [ion binding]; other site 1191523008065 domain II; other site 1191523008066 domain III; other site 1191523008067 nucleotide binding site [chemical binding]; other site 1191523008068 catalytic site [active] 1191523008069 domain IV; other site 1191523008070 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1191523008071 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1191523008072 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1191523008073 Protein of unknown function (DUF494); Region: DUF494; cl01103 1191523008074 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1191523008075 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1191523008076 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1191523008077 trimer interface [polypeptide binding]; other site 1191523008078 putative metal binding site [ion binding]; other site 1191523008079 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1191523008080 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1191523008081 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1191523008082 protein binding site [polypeptide binding]; other site 1191523008083 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1191523008084 Catalytic dyad [active] 1191523008085 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1191523008086 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1191523008087 dimer interface [polypeptide binding]; other site 1191523008088 putative anticodon binding site; other site 1191523008089 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1191523008090 motif 1; other site 1191523008091 active site 1191523008092 motif 2; other site 1191523008093 motif 3; other site 1191523008094 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1191523008095 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1191523008096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191523008097 RNA binding surface [nucleotide binding]; other site 1191523008098 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1191523008099 active site 1191523008100 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1191523008101 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1191523008102 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1191523008103 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1191523008104 active site 1191523008105 HIGH motif; other site 1191523008106 dimer interface [polypeptide binding]; other site 1191523008107 KMSKS motif; other site 1191523008108 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1191523008109 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1191523008110 active site 1191523008111 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1191523008112 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1191523008113 Ligand Binding Site [chemical binding]; other site 1191523008114 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1191523008115 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1191523008116 mce related protein; Region: MCE; pfam02470 1191523008117 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 1191523008118 Domain of unknown function DUF21; Region: DUF21; pfam01595 1191523008119 FOG: CBS domain [General function prediction only]; Region: COG0517 1191523008120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191523008121 Transporter associated domain; Region: CorC_HlyC; smart01091 1191523008122 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1191523008123 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1191523008124 dimer interface [polypeptide binding]; other site 1191523008125 ssDNA binding site [nucleotide binding]; other site 1191523008126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191523008127 Sporulation related domain; Region: SPOR; pfam05036 1191523008128 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1191523008129 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523008130 carboxyltransferase (CT) interaction site; other site 1191523008131 biotinylation site [posttranslational modification]; other site 1191523008132 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1191523008133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191523008134 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191523008135 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1191523008136 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1191523008137 MutS domain III; Region: MutS_III; pfam05192 1191523008138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523008139 Walker A/P-loop; other site 1191523008140 ATP binding site [chemical binding]; other site 1191523008141 Q-loop/lid; other site 1191523008142 ABC transporter signature motif; other site 1191523008143 Walker B; other site 1191523008144 D-loop; other site 1191523008145 H-loop/switch region; other site 1191523008146 Smr domain; Region: Smr; pfam01713 1191523008147 Colicin V production protein; Region: Colicin_V; pfam02674 1191523008148 Yqey-like protein; Region: YqeY; pfam09424 1191523008149 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1191523008150 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1191523008151 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1191523008152 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1191523008153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523008154 NAD(P) binding site [chemical binding]; other site 1191523008155 active site 1191523008156 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1191523008157 putative catalytic site [active] 1191523008158 putative metal binding site [ion binding]; other site 1191523008159 putative phosphate binding site [ion binding]; other site 1191523008160 DNA polymerase I; Provisional; Region: PRK05755 1191523008161 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1191523008162 active site 1191523008163 metal binding site 1 [ion binding]; metal-binding site 1191523008164 putative 5' ssDNA interaction site; other site 1191523008165 metal binding site 3; metal-binding site 1191523008166 metal binding site 2 [ion binding]; metal-binding site 1191523008167 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1191523008168 putative DNA binding site [nucleotide binding]; other site 1191523008169 putative metal binding site [ion binding]; other site 1191523008170 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1191523008171 active site 1191523008172 catalytic site [active] 1191523008173 substrate binding site [chemical binding]; other site 1191523008174 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1191523008175 active site 1191523008176 DNA binding site [nucleotide binding] 1191523008177 catalytic site [active] 1191523008178 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1191523008179 PQQ-like domain; Region: PQQ_2; pfam13360 1191523008180 Trp docking motif [polypeptide binding]; other site 1191523008181 active site 1191523008182 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1191523008183 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523008184 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191523008185 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 1191523008186 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 1191523008187 dimer interface [polypeptide binding]; other site 1191523008188 active site 1191523008189 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 1191523008190 dimer interface [polypeptide binding]; other site 1191523008191 active site 1191523008192 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1191523008193 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1191523008194 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191523008195 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191523008196 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191523008197 dimerization domain swap beta strand [polypeptide binding]; other site 1191523008198 regulatory protein interface [polypeptide binding]; other site 1191523008199 active site 1191523008200 regulatory phosphorylation site [posttranslational modification]; other site 1191523008201 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1191523008202 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1191523008203 substrate binding pocket [chemical binding]; other site 1191523008204 chain length determination region; other site 1191523008205 substrate-Mg2+ binding site; other site 1191523008206 catalytic residues [active] 1191523008207 aspartate-rich region 1; other site 1191523008208 active site lid residues [active] 1191523008209 aspartate-rich region 2; other site 1191523008210 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1191523008211 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1191523008212 homotetramer interface [polypeptide binding]; other site 1191523008213 FMN binding site [chemical binding]; other site 1191523008214 homodimer contacts [polypeptide binding]; other site 1191523008215 putative active site [active] 1191523008216 putative substrate binding site [chemical binding]; other site 1191523008217 MG2 domain; Region: A2M_N; pfam01835 1191523008218 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191523008219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523008220 S-adenosylmethionine binding site [chemical binding]; other site 1191523008221 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370 1191523008222 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1191523008223 SmpB-tmRNA interface; other site 1191523008224 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1191523008225 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1191523008226 active site 1191523008227 HIGH motif; other site 1191523008228 dimer interface [polypeptide binding]; other site 1191523008229 KMSKS motif; other site 1191523008230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191523008231 RNA binding surface [nucleotide binding]; other site 1191523008232 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 1191523008233 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1191523008234 Thiamine pyrophosphokinase; Region: TPK; cd07995 1191523008235 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1191523008236 active site 1191523008237 dimerization interface [polypeptide binding]; other site 1191523008238 thiamine binding site [chemical binding]; other site 1191523008239 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523008240 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008241 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191523008242 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1191523008243 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191523008244 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191523008245 catalytic residue [active] 1191523008246 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1191523008247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008249 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008250 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1191523008251 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008252 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008253 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191523008255 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1191523008256 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1191523008257 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1191523008258 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191523008259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191523008260 Walker A/P-loop; other site 1191523008261 ATP binding site [chemical binding]; other site 1191523008262 Q-loop/lid; other site 1191523008263 ABC transporter signature motif; other site 1191523008264 Walker B; other site 1191523008265 D-loop; other site 1191523008266 H-loop/switch region; other site 1191523008267 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1191523008268 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1191523008269 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1191523008270 Tetramer interface [polypeptide binding]; other site 1191523008271 active site 1191523008272 FMN-binding site [chemical binding]; other site 1191523008273 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1191523008274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191523008275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191523008276 protein binding site [polypeptide binding]; other site 1191523008277 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191523008278 protein binding site [polypeptide binding]; other site 1191523008279 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1191523008280 Recombination protein O N terminal; Region: RecO_N; pfam11967 1191523008281 Recombination protein O C terminal; Region: RecO_C; pfam02565 1191523008282 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1191523008283 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1191523008284 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191523008285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191523008286 substrate binding site [chemical binding]; other site 1191523008287 ATP binding site [chemical binding]; other site 1191523008288 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1191523008289 nudix motif; other site 1191523008290 cell surface protein SprA; Region: surface_SprA; TIGR04189 1191523008291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523008292 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1191523008293 FtsX-like permease family; Region: FtsX; pfam02687 1191523008294 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523008295 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1191523008296 FtsX-like permease family; Region: FtsX; pfam02687 1191523008297 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1191523008298 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191523008299 polygalacturonase ADPG; Region: PLN02218 1191523008300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191523008301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191523008302 DNA binding site [nucleotide binding] 1191523008303 domain linker motif; other site 1191523008304 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191523008305 dimerization interface [polypeptide binding]; other site 1191523008306 ligand binding site [chemical binding]; other site 1191523008307 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1191523008308 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1191523008309 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523008310 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008311 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008312 alpha-galactosidase; Region: PLN02808; cl17638 1191523008313 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1191523008314 Peptidase family U32; Region: Peptidase_U32; pfam01136 1191523008315 Collagenase; Region: DUF3656; pfam12392 1191523008316 Domain of unknown function (DUF897); Region: DUF897; pfam05982 1191523008317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523008318 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1191523008319 ATP-grasp domain; Region: ATP-grasp; pfam02222 1191523008320 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1191523008321 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1191523008322 Protein of unknown function DUF58; Region: DUF58; pfam01882 1191523008323 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1191523008324 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523008325 biotin synthase; Provisional; Region: PRK07094 1191523008326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523008327 FeS/SAM binding site; other site 1191523008328 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1191523008329 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 1191523008330 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1191523008331 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1191523008332 dimer interface [polypeptide binding]; other site 1191523008333 catalytic triad [active] 1191523008334 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1191523008335 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1191523008336 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1191523008337 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1191523008338 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1191523008339 Right handed beta helix region; Region: Beta_helix; pfam13229 1191523008340 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1191523008341 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1191523008342 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008343 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523008344 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523008345 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008346 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008347 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1191523008348 dimerization interface [polypeptide binding]; other site 1191523008349 putative active cleft [active] 1191523008350 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1191523008351 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523008352 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1191523008353 putative NAD(P) binding site [chemical binding]; other site 1191523008354 active site 1191523008355 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1191523008356 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1191523008357 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523008358 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523008359 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191523008360 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1191523008361 PhoU domain; Region: PhoU; pfam01895 1191523008362 PhoU domain; Region: PhoU; pfam01895 1191523008363 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1191523008364 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1191523008365 Walker A/P-loop; other site 1191523008366 ATP binding site [chemical binding]; other site 1191523008367 Q-loop/lid; other site 1191523008368 ABC transporter signature motif; other site 1191523008369 Walker B; other site 1191523008370 D-loop; other site 1191523008371 H-loop/switch region; other site 1191523008372 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1191523008373 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1191523008374 Walker A/P-loop; other site 1191523008375 ATP binding site [chemical binding]; other site 1191523008376 Q-loop/lid; other site 1191523008377 ABC transporter signature motif; other site 1191523008378 Walker B; other site 1191523008379 D-loop; other site 1191523008380 H-loop/switch region; other site 1191523008381 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1191523008382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191523008383 dimer interface [polypeptide binding]; other site 1191523008384 conserved gate region; other site 1191523008385 putative PBP binding loops; other site 1191523008386 ABC-ATPase subunit interface; other site 1191523008387 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1191523008388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191523008389 dimer interface [polypeptide binding]; other site 1191523008390 conserved gate region; other site 1191523008391 putative PBP binding loops; other site 1191523008392 ABC-ATPase subunit interface; other site 1191523008393 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1191523008394 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008395 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008396 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523008397 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523008398 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008399 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008400 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008401 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 1191523008402 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1191523008403 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1191523008404 putative acyl-acceptor binding pocket; other site 1191523008405 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1191523008406 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523008407 FtsX-like permease family; Region: FtsX; pfam02687 1191523008408 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1191523008409 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191523008410 FtsX-like permease family; Region: FtsX; pfam02687 1191523008411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191523008412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191523008413 Walker A/P-loop; other site 1191523008414 ATP binding site [chemical binding]; other site 1191523008415 Q-loop/lid; other site 1191523008416 ABC transporter signature motif; other site 1191523008417 Walker B; other site 1191523008418 D-loop; other site 1191523008419 H-loop/switch region; other site 1191523008420 ferric uptake regulator; Provisional; Region: fur; PRK09462 1191523008421 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1191523008422 metal binding site 2 [ion binding]; metal-binding site 1191523008423 putative DNA binding helix; other site 1191523008424 metal binding site 1 [ion binding]; metal-binding site 1191523008425 dimer interface [polypeptide binding]; other site 1191523008426 structural Zn2+ binding site [ion binding]; other site 1191523008427 FeoA domain; Region: FeoA; pfam04023 1191523008428 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1191523008429 G1 box; other site 1191523008430 GTP/Mg2+ binding site [chemical binding]; other site 1191523008431 G2 box; other site 1191523008432 Switch I region; other site 1191523008433 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1191523008434 G4 box; other site 1191523008435 G5 box; other site 1191523008436 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1191523008437 Nucleoside recognition; Region: Gate; pfam07670 1191523008438 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1191523008439 Nucleoside recognition; Region: Gate; pfam07670 1191523008440 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1191523008441 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191523008442 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1191523008443 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 1191523008444 Peptidase family M28; Region: Peptidase_M28; pfam04389 1191523008445 metal binding site [ion binding]; metal-binding site 1191523008446 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191523008447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1191523008448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191523008449 active site 1191523008450 metal binding site [ion binding]; metal-binding site 1191523008451 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1191523008452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191523008453 active site 1191523008454 metal binding site [ion binding]; metal-binding site 1191523008455 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1191523008456 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191523008457 N-terminal plug; other site 1191523008458 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1191523008459 ligand-binding site [chemical binding]; other site 1191523008460 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1191523008461 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1191523008462 putative active site [active] 1191523008463 putative FMN binding site [chemical binding]; other site 1191523008464 putative substrate binding site [chemical binding]; other site 1191523008465 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1191523008466 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1191523008467 dimer interface [polypeptide binding]; other site 1191523008468 PYR/PP interface [polypeptide binding]; other site 1191523008469 TPP binding site [chemical binding]; other site 1191523008470 substrate binding site [chemical binding]; other site 1191523008471 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1191523008472 Domain of unknown function; Region: EKR; pfam10371 1191523008473 4Fe-4S binding domain; Region: Fer4; pfam00037 1191523008474 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1191523008475 TPP-binding site [chemical binding]; other site 1191523008476 dimer interface [polypeptide binding]; other site 1191523008477 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1191523008478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191523008479 putative active site [active] 1191523008480 heme pocket [chemical binding]; other site 1191523008481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191523008482 dimer interface [polypeptide binding]; other site 1191523008483 phosphorylation site [posttranslational modification] 1191523008484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523008485 ATP binding site [chemical binding]; other site 1191523008486 Mg2+ binding site [ion binding]; other site 1191523008487 G-X-G motif; other site 1191523008488 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1191523008489 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1191523008490 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1191523008491 Bacterial sugar transferase; Region: Bac_transf; cl00939 1191523008492 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1191523008493 O-Antigen ligase; Region: Wzy_C; pfam04932 1191523008494 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1191523008495 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 1191523008496 Ligand Binding Site [chemical binding]; other site 1191523008497 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1191523008498 active site 1191523008499 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1191523008500 homodimer interface [polypeptide binding]; other site 1191523008501 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 1191523008502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523008503 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 1191523008504 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1191523008505 substrate binding site [chemical binding]; other site 1191523008506 glutamase interaction surface [polypeptide binding]; other site 1191523008507 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1191523008508 four helix bundle protein; Region: TIGR02436 1191523008509 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1191523008510 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1191523008511 putative active site [active] 1191523008512 oxyanion strand; other site 1191523008513 catalytic triad [active] 1191523008514 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1191523008515 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1191523008516 Ligand Binding Site [chemical binding]; other site 1191523008517 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523008518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523008519 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523008520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191523008521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191523008522 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1191523008523 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1191523008524 MULE transposase domain; Region: MULE; pfam10551 1191523008525 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191523008526 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1191523008527 putative trimer interface [polypeptide binding]; other site 1191523008528 putative active site [active] 1191523008529 putative substrate binding site [chemical binding]; other site 1191523008530 putative CoA binding site [chemical binding]; other site 1191523008531 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1191523008532 GIY-YIG motif/motif A; other site 1191523008533 putative active site [active] 1191523008534 putative metal binding site [ion binding]; other site 1191523008535 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191523008536 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191523008537 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191523008538 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1191523008539 four helix bundle protein; Region: TIGR02436 1191523008540 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1191523008541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523008542 NAD(P) binding site [chemical binding]; other site 1191523008543 active site 1191523008544 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1191523008545 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1191523008546 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1191523008547 putative homodimer interface [polypeptide binding]; other site 1191523008548 putative active site pocket [active] 1191523008549 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1191523008550 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1191523008551 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1191523008552 ring oligomerisation interface [polypeptide binding]; other site 1191523008553 ATP/Mg binding site [chemical binding]; other site 1191523008554 stacking interactions; other site 1191523008555 hinge regions; other site 1191523008556 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1191523008557 oligomerisation interface [polypeptide binding]; other site 1191523008558 mobile loop; other site 1191523008559 roof hairpin; other site 1191523008560 adenylosuccinate lyase; Provisional; Region: PRK07492 1191523008561 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1191523008562 tetramer interface [polypeptide binding]; other site 1191523008563 active site 1191523008564 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1191523008565 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191523008566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191523008567 protein binding site [polypeptide binding]; other site 1191523008568 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1191523008569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523008570 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1191523008571 NAD binding site [chemical binding]; other site 1191523008572 putative substrate binding site 2 [chemical binding]; other site 1191523008573 putative substrate binding site 1 [chemical binding]; other site 1191523008574 active site 1191523008575 Chain length determinant protein; Region: Wzz; cl15801 1191523008576 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1191523008577 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1191523008578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191523008579 Magnesium ion binding site [ion binding]; other site 1191523008580 SLBB domain; Region: SLBB; pfam10531 1191523008581 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1191523008582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1191523008583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523008584 S-adenosylmethionine binding site [chemical binding]; other site 1191523008585 recombination protein RecR; Reviewed; Region: recR; PRK00076 1191523008586 RecR protein; Region: RecR; pfam02132 1191523008587 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1191523008588 putative active site [active] 1191523008589 putative metal-binding site [ion binding]; other site 1191523008590 tetramer interface [polypeptide binding]; other site 1191523008591 hypothetical protein; Validated; Region: PRK00153 1191523008592 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1191523008593 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1191523008594 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1191523008595 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1191523008596 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1191523008597 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1191523008598 putative active site [active] 1191523008599 catalytic triad [active] 1191523008600 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1191523008601 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1191523008602 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1191523008603 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1191523008604 CoA binding domain; Region: CoA_binding; pfam02629 1191523008605 CoA-ligase; Region: Ligase_CoA; pfam00549 1191523008606 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1191523008607 active site 1191523008608 multimer interface [polypeptide binding]; other site 1191523008609 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1191523008610 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1191523008611 dimer interface [polypeptide binding]; other site 1191523008612 active site residues [active] 1191523008613 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1191523008614 agmatinase; Region: agmatinase; TIGR01230 1191523008615 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1191523008616 putative active site [active] 1191523008617 Mn binding site [ion binding]; other site 1191523008618 Preprotein translocase subunit; Region: YajC; pfam02699 1191523008619 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1191523008620 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1191523008621 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008622 Domain of unknown function DUF21; Region: DUF21; pfam01595 1191523008623 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1191523008624 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191523008625 Transporter associated domain; Region: CorC_HlyC; smart01091 1191523008626 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1191523008627 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 1191523008628 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1191523008629 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1191523008630 ATP binding site [chemical binding]; other site 1191523008631 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 1191523008632 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1191523008633 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1191523008634 NADP+ binding site [chemical binding]; other site 1191523008635 folate binding site [chemical binding]; other site 1191523008636 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1191523008637 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1191523008638 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1191523008639 nucleotide binding site/active site [active] 1191523008640 HIT family signature motif; other site 1191523008641 catalytic residue [active] 1191523008642 elongation factor G; Reviewed; Region: PRK12740 1191523008643 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1191523008644 Switch II region; other site 1191523008645 G4 box; other site 1191523008646 G5 box; other site 1191523008647 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1191523008648 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1191523008649 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1191523008650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1191523008651 G1 box; other site 1191523008652 GTP/Mg2+ binding site [chemical binding]; other site 1191523008653 G2 box; other site 1191523008654 Switch I region; other site 1191523008655 YtxH-like protein; Region: YtxH; pfam12732 1191523008656 Maf-like protein; Region: Maf; pfam02545 1191523008657 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1191523008658 active site 1191523008659 dimer interface [polypeptide binding]; other site 1191523008660 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1191523008661 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1191523008662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191523008663 non-specific DNA binding site [nucleotide binding]; other site 1191523008664 salt bridge; other site 1191523008665 sequence-specific DNA binding site [nucleotide binding]; other site 1191523008666 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1191523008667 short chain dehydrogenase; Provisional; Region: PRK06924 1191523008668 classical (c) SDRs; Region: SDR_c; cd05233 1191523008669 NAD(P) binding site [chemical binding]; other site 1191523008670 active site 1191523008671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191523008672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1191523008673 active site 1191523008674 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1191523008675 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191523008676 carboxyltransferase (CT) interaction site; other site 1191523008677 biotinylation site [posttranslational modification]; other site 1191523008678 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1191523008679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191523008680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191523008681 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1191523008682 enoyl-CoA hydratase; Provisional; Region: PRK05995 1191523008683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191523008684 substrate binding site [chemical binding]; other site 1191523008685 oxyanion hole (OAH) forming residues; other site 1191523008686 trimer interface [polypeptide binding]; other site 1191523008687 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1191523008688 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1191523008689 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 1191523008690 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191523008691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523008692 NAD(P) binding site [chemical binding]; other site 1191523008693 active site 1191523008694 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1191523008695 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1191523008696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523008697 catalytic residue [active] 1191523008698 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1191523008699 aldehyde dehydrogenase family 7 member; Region: PLN02315 1191523008700 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1191523008701 tetrameric interface [polypeptide binding]; other site 1191523008702 NAD binding site [chemical binding]; other site 1191523008703 catalytic residues [active] 1191523008704 L-lysine aminotransferase; Provisional; Region: PRK08297 1191523008705 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191523008706 inhibitor-cofactor binding pocket; inhibition site 1191523008707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523008708 catalytic residue [active] 1191523008709 Predicted methyltransferases [General function prediction only]; Region: COG0313 1191523008710 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1191523008711 putative SAM binding site [chemical binding]; other site 1191523008712 putative homodimer interface [polypeptide binding]; other site 1191523008713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191523008714 active site 1191523008715 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1191523008716 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1191523008717 FMN binding site [chemical binding]; other site 1191523008718 active site 1191523008719 catalytic residues [active] 1191523008720 substrate binding site [chemical binding]; other site 1191523008721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523008722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191523008723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191523008724 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1191523008725 Cysteine-rich domain; Region: CCG; pfam02754 1191523008726 Cysteine-rich domain; Region: CCG; pfam02754 1191523008727 BioY family; Region: BioY; pfam02632 1191523008728 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1191523008729 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1191523008730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191523008731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1191523008732 active site 1191523008733 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1191523008734 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1191523008735 catalytic residues [active] 1191523008736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1191523008737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191523008738 ligand binding site [chemical binding]; other site 1191523008739 flexible hinge region; other site 1191523008740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191523008741 Ligand Binding Site [chemical binding]; other site 1191523008742 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1191523008743 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1191523008744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523008745 binding surface 1191523008746 TPR motif; other site 1191523008747 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1191523008748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523008749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523008750 DNA binding residues [nucleotide binding] 1191523008751 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1191523008752 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1191523008753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191523008754 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1191523008755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191523008756 DNA binding residues [nucleotide binding] 1191523008757 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191523008758 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191523008759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191523008760 catalytic residue [active] 1191523008761 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 1191523008762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191523008763 FeS/SAM binding site; other site 1191523008764 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1191523008765 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1191523008766 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1191523008767 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1191523008768 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1191523008769 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1191523008770 glutamine binding [chemical binding]; other site 1191523008771 catalytic triad [active] 1191523008772 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1191523008773 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1191523008774 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1191523008775 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1191523008776 active site 1191523008777 ribulose/triose binding site [chemical binding]; other site 1191523008778 phosphate binding site [ion binding]; other site 1191523008779 substrate (anthranilate) binding pocket [chemical binding]; other site 1191523008780 product (indole) binding pocket [chemical binding]; other site 1191523008781 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1191523008782 active site 1191523008783 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1191523008784 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1191523008785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523008786 catalytic residue [active] 1191523008787 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1191523008788 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1191523008789 substrate binding site [chemical binding]; other site 1191523008790 active site 1191523008791 catalytic residues [active] 1191523008792 heterodimer interface [polypeptide binding]; other site 1191523008793 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1191523008794 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1191523008795 active site residue [active] 1191523008796 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1191523008797 active site residue [active] 1191523008798 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1191523008799 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1191523008800 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1191523008801 metal binding site [ion binding]; metal-binding site 1191523008802 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1191523008803 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1191523008804 substrate binding site [chemical binding]; other site 1191523008805 glutamase interaction surface [polypeptide binding]; other site 1191523008806 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1191523008807 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1191523008808 catalytic residues [active] 1191523008809 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1191523008810 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1191523008811 putative active site [active] 1191523008812 oxyanion strand; other site 1191523008813 catalytic triad [active] 1191523008814 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1191523008815 putative active site pocket [active] 1191523008816 4-fold oligomerization interface [polypeptide binding]; other site 1191523008817 metal binding residues [ion binding]; metal-binding site 1191523008818 3-fold/trimer interface [polypeptide binding]; other site 1191523008819 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1191523008820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191523008821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191523008822 homodimer interface [polypeptide binding]; other site 1191523008823 catalytic residue [active] 1191523008824 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1191523008825 histidinol dehydrogenase; Region: hisD; TIGR00069 1191523008826 NAD binding site [chemical binding]; other site 1191523008827 dimerization interface [polypeptide binding]; other site 1191523008828 product binding site; other site 1191523008829 substrate binding site [chemical binding]; other site 1191523008830 zinc binding site [ion binding]; other site 1191523008831 catalytic residues [active] 1191523008832 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1191523008833 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1191523008834 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1191523008835 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1191523008836 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191523008837 active site 1191523008838 metal binding site [ion binding]; metal-binding site 1191523008839 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191523008840 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1191523008841 metal binding triad [ion binding]; metal-binding site 1191523008842 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191523008843 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1191523008844 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1191523008845 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1191523008846 NAD(P) binding site [chemical binding]; other site 1191523008847 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1191523008848 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191523008849 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 1191523008850 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1191523008851 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1191523008852 Transglycosylase; Region: Transgly; pfam00912 1191523008853 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1191523008854 Ferritin-like domain; Region: Ferritin; pfam00210 1191523008855 ferroxidase diiron center [ion binding]; other site 1191523008856 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1191523008857 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1191523008858 Ligand binding site [chemical binding]; other site 1191523008859 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1191523008860 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1191523008861 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1191523008862 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1191523008863 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1191523008864 UvrB/uvrC motif; Region: UVR; pfam02151 1191523008865 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 1191523008866 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1191523008867 active site 1191523008868 dimer interface [polypeptide binding]; other site 1191523008869 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1191523008870 trimer interface [polypeptide binding]; other site 1191523008871 active site 1191523008872 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1191523008873 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1191523008874 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191523008875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191523008876 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1191523008877 rod shape-determining protein MreC; Provisional; Region: PRK13922 1191523008878 rod shape-determining protein MreC; Region: MreC; pfam04085 1191523008879 rod shape-determining protein MreB; Provisional; Region: PRK13927 1191523008880 MreB and similar proteins; Region: MreB_like; cd10225 1191523008881 nucleotide binding site [chemical binding]; other site 1191523008882 Mg binding site [ion binding]; other site 1191523008883 putative protofilament interaction site [polypeptide binding]; other site 1191523008884 RodZ interaction site [polypeptide binding]; other site 1191523008885 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1191523008886 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1191523008887 purine monophosphate binding site [chemical binding]; other site 1191523008888 dimer interface [polypeptide binding]; other site 1191523008889 putative catalytic residues [active] 1191523008890 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1191523008891 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1191523008892 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1191523008893 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1191523008894 active site 1191523008895 substrate binding site [chemical binding]; other site 1191523008896 cosubstrate binding site; other site 1191523008897 catalytic site [active] 1191523008898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523008899 TPR motif; other site 1191523008900 binding surface 1191523008901 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1191523008902 active site 1191523008903 CTP synthetase; Validated; Region: pyrG; PRK05380 1191523008904 Catalytic site [active] 1191523008905 UTP binding site [chemical binding]; other site 1191523008906 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1191523008907 active site 1191523008908 putative oxyanion hole; other site 1191523008909 catalytic triad [active] 1191523008910 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191523008911 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191523008912 catalytic residue [active] 1191523008913 type I citrate synthase; Reviewed; Region: PRK09569 1191523008914 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 1191523008915 oxalacetate binding site [chemical binding]; other site 1191523008916 citrylCoA binding site [chemical binding]; other site 1191523008917 coenzyme A binding site [chemical binding]; other site 1191523008918 catalytic triad [active] 1191523008919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191523008920 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1191523008921 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1191523008922 active site lid residues [active] 1191523008923 substrate binding pocket [chemical binding]; other site 1191523008924 catalytic residues [active] 1191523008925 substrate-Mg2+ binding site; other site 1191523008926 aspartate-rich region 1; other site 1191523008927 aspartate-rich region 2; other site 1191523008928 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1191523008929 active site lid residues [active] 1191523008930 substrate binding pocket [chemical binding]; other site 1191523008931 catalytic residues [active] 1191523008932 substrate-Mg2+ binding site; other site 1191523008933 aspartate-rich region 1; other site 1191523008934 aspartate-rich region 2; other site 1191523008935 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1191523008936 Transglycosylase; Region: Transgly; pfam00912 1191523008937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1191523008938 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1191523008939 putative active site [active] 1191523008940 putative metal binding site [ion binding]; other site 1191523008941 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1191523008942 Zn binding site [ion binding]; other site 1191523008943 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1191523008944 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1191523008945 ligand binding site; other site 1191523008946 oligomer interface; other site 1191523008947 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1191523008948 dimer interface [polypeptide binding]; other site 1191523008949 N-terminal domain interface [polypeptide binding]; other site 1191523008950 sulfate 1 binding site; other site 1191523008951 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 1191523008952 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1191523008953 GIY-YIG motif/motif A; other site 1191523008954 active site 1191523008955 catalytic site [active] 1191523008956 putative DNA binding site [nucleotide binding]; other site 1191523008957 metal binding site [ion binding]; metal-binding site 1191523008958 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1191523008959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191523008960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191523008961 DNA binding site [nucleotide binding] 1191523008962 domain linker motif; other site 1191523008963 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191523008964 ligand binding site [chemical binding]; other site 1191523008965 dimerization interface [polypeptide binding]; other site 1191523008966 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1191523008967 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1191523008968 dimer interface [polypeptide binding]; other site 1191523008969 active site 1191523008970 metal binding site [ion binding]; metal-binding site 1191523008971 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1191523008972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191523008973 S-adenosylmethionine binding site [chemical binding]; other site 1191523008974 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1191523008975 oxyanion hole [active] 1191523008976 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1191523008977 catalytic triad [active] 1191523008978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191523008979 TPR motif; other site 1191523008980 binding surface 1191523008981 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1191523008982 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1191523008983 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191523008984 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1191523008985 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1191523008986 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1191523008987 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191523008989 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1191523008990 active site 1191523008991 catalytic residues [active] 1191523008992 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1191523008993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191523008994 NAD(P) binding site [chemical binding]; other site 1191523008995 active site 1191523008996 mannonate dehydratase; Provisional; Region: PRK03906 1191523008997 mannonate dehydratase; Region: uxuA; TIGR00695 1191523008998 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1191523008999 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1191523009000 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191523009001 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1191523009002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191523009003 Beta-Casp domain; Region: Beta-Casp; smart01027 1191523009004 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1191523009005 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191523009006 Interdomain contacts; other site 1191523009007 Cytokine receptor motif; other site 1191523009008 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1191523009009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191523009010 ATP binding site [chemical binding]; other site 1191523009011 Mg2+ binding site [ion binding]; other site 1191523009012 G-X-G motif; other site 1191523009013 malate dehydrogenase; Reviewed; Region: PRK06223 1191523009014 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1191523009015 NAD(P) binding site [chemical binding]; other site 1191523009016 dimer interface [polypeptide binding]; other site 1191523009017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191523009018 substrate binding site [chemical binding]; other site 1191523009019 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1191523009020 50S ribosomal protein L21; Validated; Region: rplU; PRK05573