-- dump date 20140619_140609 -- class Genbank::misc_feature -- table misc_feature_note -- id note 940190000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 940190000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 940190000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190000004 Walker A motif; other site 940190000005 ATP binding site [chemical binding]; other site 940190000006 Walker B motif; other site 940190000007 arginine finger; other site 940190000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 940190000009 DnaA box-binding interface [nucleotide binding]; other site 940190000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 940190000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 940190000012 putative DNA binding surface [nucleotide binding]; other site 940190000013 dimer interface [polypeptide binding]; other site 940190000014 beta-clamp/clamp loader binding surface; other site 940190000015 beta-clamp/translesion DNA polymerase binding surface; other site 940190000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 940190000017 recombination protein F; Reviewed; Region: recF; PRK00064 940190000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 940190000019 Walker A/P-loop; other site 940190000020 ATP binding site [chemical binding]; other site 940190000021 Q-loop/lid; other site 940190000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190000023 ABC transporter signature motif; other site 940190000024 Walker B; other site 940190000025 D-loop; other site 940190000026 H-loop/switch region; other site 940190000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 940190000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000029 Mg2+ binding site [ion binding]; other site 940190000030 G-X-G motif; other site 940190000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 940190000032 anchoring element; other site 940190000033 dimer interface [polypeptide binding]; other site 940190000034 ATP binding site [chemical binding]; other site 940190000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 940190000036 active site 940190000037 putative metal-binding site [ion binding]; other site 940190000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 940190000039 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 940190000040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000041 Mg2+ binding site [ion binding]; other site 940190000042 G-X-G motif; other site 940190000043 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 940190000044 anchoring element; other site 940190000045 dimer interface [polypeptide binding]; other site 940190000046 ATP binding site [chemical binding]; other site 940190000047 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 940190000048 active site 940190000049 putative metal-binding site [ion binding]; other site 940190000050 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 940190000051 DNA gyrase subunit A; Validated; Region: PRK05560 940190000052 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 940190000053 CAP-like domain; other site 940190000054 active site 940190000055 primary dimer interface [polypeptide binding]; other site 940190000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190000061 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 940190000062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 940190000063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 940190000064 dimer interface [polypeptide binding]; other site 940190000065 ssDNA binding site [nucleotide binding]; other site 940190000066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 940190000067 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 940190000068 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 940190000069 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 940190000070 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 940190000071 DHH family; Region: DHH; pfam01368 940190000072 DHHA1 domain; Region: DHHA1; pfam02272 940190000073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 940190000074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 940190000075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 940190000076 replicative DNA helicase; Provisional; Region: PRK05748 940190000077 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 940190000078 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 940190000079 Walker A motif; other site 940190000080 ATP binding site [chemical binding]; other site 940190000081 Walker B motif; other site 940190000082 DNA binding loops [nucleotide binding] 940190000083 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 940190000084 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 940190000085 GDP-binding site [chemical binding]; other site 940190000086 ACT binding site; other site 940190000087 IMP binding site; other site 940190000088 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 940190000089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190000090 Walker A/P-loop; other site 940190000091 ATP binding site [chemical binding]; other site 940190000092 Q-loop/lid; other site 940190000093 ABC transporter signature motif; other site 940190000094 Walker B; other site 940190000095 D-loop; other site 940190000096 H-loop/switch region; other site 940190000097 ABC transporter; Region: ABC_tran_2; pfam12848 940190000098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 940190000099 potential frameshift: common BLAST hit: gi|29374677|ref|NP_813829.1| sigma-54 factor interaction domain-containing protein 940190000100 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 940190000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190000102 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 940190000103 Walker A motif; other site 940190000104 ATP binding site [chemical binding]; other site 940190000105 Walker B motif; other site 940190000106 arginine finger; other site 940190000107 Transcriptional antiterminator [Transcription]; Region: COG3933 940190000108 PRD domain; Region: PRD; pfam00874 940190000109 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 940190000110 active pocket/dimerization site; other site 940190000111 active site 940190000112 PRD domain; Region: PRD; pfam00874 940190000113 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 940190000114 active site 940190000115 phosphorylation site [posttranslational modification] 940190000116 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 940190000117 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 940190000118 active pocket/dimerization site; other site 940190000119 active site 940190000120 phosphorylation site [posttranslational modification] 940190000121 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 940190000122 active site 940190000123 phosphorylation site [posttranslational modification] 940190000124 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 940190000125 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 940190000126 Domain of unknown function (DUF956); Region: DUF956; pfam06115 940190000127 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 940190000128 potential frameshift: common BLAST hit: gi|312126907|ref|YP_003991781.1| fibronectin type III domain-containing protein 940190000129 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 940190000130 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 940190000131 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 940190000132 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 940190000133 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 940190000134 potential frameshift: common BLAST hit: gi|290955699|ref|YP_003486881.1| hydrolase 940190000135 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190000136 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190000137 active site 940190000138 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 940190000139 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 940190000140 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 940190000141 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 940190000142 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 940190000143 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 940190000144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190000145 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 940190000146 Predicted membrane protein [Function unknown]; Region: COG3463 940190000147 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 940190000148 trimer interface [polypeptide binding]; other site 940190000149 active site 940190000150 DNA repair protein RadA; Provisional; Region: PRK11823 940190000151 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 940190000152 Walker A motif/ATP binding site; other site 940190000153 ATP binding site [chemical binding]; other site 940190000154 Walker B motif; other site 940190000155 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 940190000156 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 940190000157 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 940190000158 putative active site [active] 940190000159 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 940190000160 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 940190000161 HIGH motif; other site 940190000162 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 940190000163 active site 940190000164 KMSKS motif; other site 940190000165 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 940190000166 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 940190000167 active site 940190000168 HIGH motif; other site 940190000169 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 940190000170 KMSKS motif; other site 940190000171 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 940190000172 tRNA binding surface [nucleotide binding]; other site 940190000173 anticodon binding site; other site 940190000174 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 940190000175 active site 940190000176 metal binding site [ion binding]; metal-binding site 940190000177 dimerization interface [polypeptide binding]; other site 940190000178 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 940190000179 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 940190000180 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 940190000181 YacP-like NYN domain; Region: NYN_YacP; pfam05991 940190000182 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 940190000183 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 940190000184 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 940190000185 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 940190000186 metal binding site [ion binding]; metal-binding site 940190000187 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190000188 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 940190000189 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 940190000190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190000191 ABC-ATPase subunit interface; other site 940190000192 dimer interface [polypeptide binding]; other site 940190000193 putative PBP binding regions; other site 940190000194 pur operon repressor; Provisional; Region: PRK09213 940190000195 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 940190000196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190000197 active site 940190000198 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 940190000199 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 940190000200 putative active site [active] 940190000201 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 940190000202 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 940190000203 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 940190000204 elongation factor P; Validated; Region: PRK00529 940190000205 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 940190000206 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 940190000207 RNA binding site [nucleotide binding]; other site 940190000208 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 940190000209 RNA binding site [nucleotide binding]; other site 940190000210 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 940190000211 Low molecular weight phosphatase family; Region: LMWPc; cd00115 940190000212 active site 940190000213 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 940190000214 active site 940190000215 catalytic site [active] 940190000216 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 940190000217 23S rRNA interface [nucleotide binding]; other site 940190000218 L3 interface [polypeptide binding]; other site 940190000219 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 940190000220 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 940190000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190000222 active site 940190000223 phosphorylation site [posttranslational modification] 940190000224 intermolecular recognition site; other site 940190000225 dimerization interface [polypeptide binding]; other site 940190000226 LytTr DNA-binding domain; Region: LytTR; cl04498 940190000227 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 940190000228 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 940190000229 ATP binding site [chemical binding]; other site 940190000230 Mg2+ binding site [ion binding]; other site 940190000231 G-X-G motif; other site 940190000232 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 940190000233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 940190000234 Walker A/P-loop; other site 940190000235 ATP binding site [chemical binding]; other site 940190000236 Q-loop/lid; other site 940190000237 ABC transporter signature motif; other site 940190000238 Walker B; other site 940190000239 D-loop; other site 940190000240 H-loop/switch region; other site 940190000241 topology modulation protein; Reviewed; Region: PRK08118 940190000242 AAA domain; Region: AAA_17; pfam13207 940190000243 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 940190000244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 940190000245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190000246 non-specific DNA binding site [nucleotide binding]; other site 940190000247 salt bridge; other site 940190000248 sequence-specific DNA binding site [nucleotide binding]; other site 940190000249 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 940190000250 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 940190000251 trimer interface [polypeptide binding]; other site 940190000252 active site 940190000253 substrate binding site [chemical binding]; other site 940190000254 CoA binding site [chemical binding]; other site 940190000255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 940190000256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190000257 active site 940190000258 phosphorylation site [posttranslational modification] 940190000259 intermolecular recognition site; other site 940190000260 dimerization interface [polypeptide binding]; other site 940190000261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 940190000262 DNA binding residues [nucleotide binding] 940190000263 dimerization interface [polypeptide binding]; other site 940190000264 Histidine kinase; Region: HisKA_3; pfam07730 940190000265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000266 ATP binding site [chemical binding]; other site 940190000267 Mg2+ binding site [ion binding]; other site 940190000268 G-X-G motif; other site 940190000269 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 940190000270 ABC-2 type transporter; Region: ABC2_membrane; cl17235 940190000271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190000272 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 940190000273 Walker A/P-loop; other site 940190000274 ATP binding site [chemical binding]; other site 940190000275 Q-loop/lid; other site 940190000276 ABC transporter signature motif; other site 940190000277 Walker B; other site 940190000278 D-loop; other site 940190000279 H-loop/switch region; other site 940190000280 Glycerate kinase family; Region: Gly_kinase; cl00841 940190000281 Glycerate kinase family; Region: Gly_kinase; cl00841 940190000282 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 940190000283 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 940190000284 WxL domain surface cell wall-binding; Region: WxL; pfam13731 940190000285 WxL domain surface cell wall-binding; Region: WxL; pfam13731 940190000286 legume lectins; Region: lectin_L-type; cl14058 940190000287 carbohydrate binding site [chemical binding]; other site 940190000288 metal binding site [ion binding]; metal-binding site 940190000289 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 940190000290 WxL domain surface cell wall-binding; Region: WxL; pfam13731 940190000291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190000292 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 940190000293 Walker A/P-loop; other site 940190000294 ATP binding site [chemical binding]; other site 940190000295 Q-loop/lid; other site 940190000296 ABC transporter signature motif; other site 940190000297 Walker B; other site 940190000298 D-loop; other site 940190000299 H-loop/switch region; other site 940190000300 potential frameshift: common BLAST hit: gi|300174212|ref|YP_003773378.1| bacteriocin-associated integral membrane protein 940190000301 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 940190000302 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 940190000303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190000304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190000305 Walker A/P-loop; other site 940190000306 ATP binding site [chemical binding]; other site 940190000307 Q-loop/lid; other site 940190000308 ABC transporter signature motif; other site 940190000309 Walker B; other site 940190000310 D-loop; other site 940190000311 H-loop/switch region; other site 940190000312 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 940190000313 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 940190000314 NAD binding site [chemical binding]; other site 940190000315 substrate binding site [chemical binding]; other site 940190000316 catalytic Zn binding site [ion binding]; other site 940190000317 tetramer interface [polypeptide binding]; other site 940190000318 structural Zn binding site [ion binding]; other site 940190000319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 940190000320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190000321 dimer interface [polypeptide binding]; other site 940190000322 phosphorylation site [posttranslational modification] 940190000323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000324 ATP binding site [chemical binding]; other site 940190000325 Mg2+ binding site [ion binding]; other site 940190000326 G-X-G motif; other site 940190000327 Predicted secreted protein [Function unknown]; Region: COG4086 940190000328 potential frameshift: common BLAST hit: gi|328956644|ref|YP_004374030.1| extracellular solute-binding protein family 1 940190000329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190000330 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190000332 dimer interface [polypeptide binding]; other site 940190000333 conserved gate region; other site 940190000334 putative PBP binding loops; other site 940190000335 ABC-ATPase subunit interface; other site 940190000336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190000337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190000338 dimer interface [polypeptide binding]; other site 940190000339 conserved gate region; other site 940190000340 putative PBP binding loops; other site 940190000341 ABC-ATPase subunit interface; other site 940190000342 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 940190000343 active site 940190000344 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 940190000345 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 940190000346 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 940190000347 dimer interface [polypeptide binding]; other site 940190000348 FMN binding site [chemical binding]; other site 940190000349 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 940190000350 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 940190000351 NAD binding site [chemical binding]; other site 940190000352 homotetramer interface [polypeptide binding]; other site 940190000353 homodimer interface [polypeptide binding]; other site 940190000354 substrate binding site [chemical binding]; other site 940190000355 active site 940190000356 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 940190000357 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 940190000358 dimer interface [polypeptide binding]; other site 940190000359 active site 940190000360 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 940190000361 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 940190000362 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 940190000363 Substrate binding site; other site 940190000364 Mg++ binding site; other site 940190000365 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 940190000366 active site 940190000367 substrate binding site [chemical binding]; other site 940190000368 CoA binding site [chemical binding]; other site 940190000369 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 940190000370 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 940190000371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190000372 active site 940190000373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190000374 Coenzyme A binding pocket [chemical binding]; other site 940190000375 Predicted small secreted protein [Function unknown]; Region: COG5584 940190000376 Predicted small secreted protein [Function unknown]; Region: COG5584 940190000377 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 940190000378 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 940190000379 oligomer interface [polypeptide binding]; other site 940190000380 active site 940190000381 metal binding site [ion binding]; metal-binding site 940190000382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 940190000383 catalytic residues [active] 940190000384 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 940190000385 Ligand Binding Site [chemical binding]; other site 940190000386 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 940190000387 putative tRNA-binding site [nucleotide binding]; other site 940190000388 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 940190000389 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 940190000390 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 940190000391 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 940190000392 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 940190000393 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 940190000394 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 940190000395 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 940190000396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190000397 non-specific DNA binding site [nucleotide binding]; other site 940190000398 salt bridge; other site 940190000399 sequence-specific DNA binding site [nucleotide binding]; other site 940190000400 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 940190000401 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 940190000402 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 940190000403 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 940190000404 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 940190000405 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 940190000406 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 940190000407 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 940190000408 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 940190000409 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 940190000410 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 940190000411 putative translocon binding site; other site 940190000412 protein-rRNA interface [nucleotide binding]; other site 940190000413 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 940190000414 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 940190000415 G-X-X-G motif; other site 940190000416 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 940190000417 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 940190000418 23S rRNA interface [nucleotide binding]; other site 940190000419 5S rRNA interface [nucleotide binding]; other site 940190000420 putative antibiotic binding site [chemical binding]; other site 940190000421 L25 interface [polypeptide binding]; other site 940190000422 L27 interface [polypeptide binding]; other site 940190000423 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 940190000424 23S rRNA interface [nucleotide binding]; other site 940190000425 putative translocon interaction site; other site 940190000426 signal recognition particle (SRP54) interaction site; other site 940190000427 L23 interface [polypeptide binding]; other site 940190000428 trigger factor interaction site; other site 940190000429 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 940190000430 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 940190000431 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 940190000432 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 940190000433 RNA binding site [nucleotide binding]; other site 940190000434 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 940190000435 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 940190000436 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 940190000437 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 940190000438 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 940190000439 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 940190000440 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 940190000441 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 940190000442 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 940190000443 5S rRNA interface [nucleotide binding]; other site 940190000444 L27 interface [polypeptide binding]; other site 940190000445 23S rRNA interface [nucleotide binding]; other site 940190000446 L5 interface [polypeptide binding]; other site 940190000447 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 940190000448 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 940190000449 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 940190000450 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 940190000451 23S rRNA binding site [nucleotide binding]; other site 940190000452 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 940190000453 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 940190000454 SecY translocase; Region: SecY; pfam00344 940190000455 adenylate kinase; Reviewed; Region: adk; PRK00279 940190000456 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 940190000457 AMP-binding site [chemical binding]; other site 940190000458 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 940190000459 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 940190000460 rRNA binding site [nucleotide binding]; other site 940190000461 predicted 30S ribosome binding site; other site 940190000462 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 940190000463 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 940190000464 30S ribosomal protein S13; Region: bact_S13; TIGR03631 940190000465 30S ribosomal protein S11; Validated; Region: PRK05309 940190000466 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 940190000467 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 940190000468 alphaNTD homodimer interface [polypeptide binding]; other site 940190000469 alphaNTD - beta interaction site [polypeptide binding]; other site 940190000470 alphaNTD - beta' interaction site [polypeptide binding]; other site 940190000471 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 940190000472 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 940190000473 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 940190000474 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 940190000475 Walker A/P-loop; other site 940190000476 ATP binding site [chemical binding]; other site 940190000477 Q-loop/lid; other site 940190000478 ABC transporter signature motif; other site 940190000479 Walker B; other site 940190000480 D-loop; other site 940190000481 H-loop/switch region; other site 940190000482 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 940190000483 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 940190000484 Walker A/P-loop; other site 940190000485 ATP binding site [chemical binding]; other site 940190000486 Q-loop/lid; other site 940190000487 ABC transporter signature motif; other site 940190000488 Walker B; other site 940190000489 D-loop; other site 940190000490 H-loop/switch region; other site 940190000491 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 940190000492 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 940190000493 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 940190000494 dimerization interface 3.5A [polypeptide binding]; other site 940190000495 active site 940190000496 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 940190000497 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 940190000498 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 940190000499 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 940190000500 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 940190000501 sensory histidine kinase DcuS; Provisional; Region: PRK11086 940190000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000503 ATP binding site [chemical binding]; other site 940190000504 Mg2+ binding site [ion binding]; other site 940190000505 G-X-G motif; other site 940190000506 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 940190000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190000508 active site 940190000509 phosphorylation site [posttranslational modification] 940190000510 intermolecular recognition site; other site 940190000511 dimerization interface [polypeptide binding]; other site 940190000512 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 940190000513 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 940190000514 NAD binding site [chemical binding]; other site 940190000515 Membrane transport protein; Region: Mem_trans; pfam03547 940190000516 glucose-1-dehydrogenase; Provisional; Region: PRK08936 940190000517 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 940190000518 NAD binding site [chemical binding]; other site 940190000519 homodimer interface [polypeptide binding]; other site 940190000520 active site 940190000521 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 940190000522 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 940190000523 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 940190000524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 940190000525 catalytic residue [active] 940190000526 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 940190000527 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 940190000528 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 940190000529 Ligand Binding Site [chemical binding]; other site 940190000530 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 940190000531 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 940190000532 CoA binding domain; Region: CoA_binding; pfam02629 940190000533 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 940190000534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 940190000535 active site 940190000536 HIGH motif; other site 940190000537 nucleotide binding site [chemical binding]; other site 940190000538 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 940190000539 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 940190000540 active site 940190000541 KMSKS motif; other site 940190000542 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 940190000543 tRNA binding surface [nucleotide binding]; other site 940190000544 anticodon binding site; other site 940190000545 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 940190000546 Uncharacterized conserved protein [Function unknown]; Region: COG0398 940190000547 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 940190000548 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 940190000549 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 940190000550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190000551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 940190000552 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 940190000553 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 940190000554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190000555 motif II; other site 940190000556 hypothetical protein; Reviewed; Region: PRK00024 940190000557 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 940190000558 MPN+ (JAMM) motif; other site 940190000559 Zinc-binding site [ion binding]; other site 940190000560 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 940190000561 DNA-binding site [nucleotide binding]; DNA binding site 940190000562 RNA-binding motif; other site 940190000563 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 940190000564 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 940190000565 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 940190000566 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 940190000567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190000568 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190000569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190000570 Walker A/P-loop; other site 940190000571 ATP binding site [chemical binding]; other site 940190000572 Q-loop/lid; other site 940190000573 ABC transporter signature motif; other site 940190000574 Walker B; other site 940190000575 D-loop; other site 940190000576 H-loop/switch region; other site 940190000577 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190000578 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190000579 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 940190000580 Walker A/P-loop; other site 940190000581 ATP binding site [chemical binding]; other site 940190000582 Q-loop/lid; other site 940190000583 ABC transporter signature motif; other site 940190000584 Walker B; other site 940190000585 D-loop; other site 940190000586 H-loop/switch region; other site 940190000587 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 940190000588 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 940190000589 trimer interface [polypeptide binding]; other site 940190000590 putative metal binding site [ion binding]; other site 940190000591 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 940190000592 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 940190000593 active site 940190000594 homodimer interface [polypeptide binding]; other site 940190000595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 940190000596 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 940190000597 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 940190000598 catalytic residues [active] 940190000599 catalytic nucleophile [active] 940190000600 Presynaptic Site I dimer interface [polypeptide binding]; other site 940190000601 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 940190000602 Synaptic Flat tetramer interface [polypeptide binding]; other site 940190000603 Synaptic Site I dimer interface [polypeptide binding]; other site 940190000604 DNA binding site [nucleotide binding] 940190000605 Cna protein B-type domain; Region: Cna_B; pfam05738 940190000606 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190000607 domain interaction interfaces [polypeptide binding]; other site 940190000608 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190000609 domain interaction interfaces [polypeptide binding]; other site 940190000610 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190000611 domain interaction interfaces [polypeptide binding]; other site 940190000612 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190000613 domain interaction interfaces [polypeptide binding]; other site 940190000614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 940190000615 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 940190000616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 940190000617 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 940190000618 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 940190000619 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 940190000620 active site 940190000621 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 940190000622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 940190000623 FeS/SAM binding site; other site 940190000624 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 940190000625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190000626 DNA-binding site [nucleotide binding]; DNA binding site 940190000627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 940190000628 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 940190000629 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 940190000630 dimer interface [polypeptide binding]; other site 940190000631 active site 940190000632 glycine loop; other site 940190000633 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 940190000634 active site 940190000635 intersubunit interactions; other site 940190000636 catalytic residue [active] 940190000637 hypothetical protein 940190000638 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 940190000639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190000640 active site 940190000641 phosphorylation site [posttranslational modification] 940190000642 intermolecular recognition site; other site 940190000643 dimerization interface [polypeptide binding]; other site 940190000644 Histidine kinase; Region: His_kinase; pfam06580 940190000645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000646 ATP binding site [chemical binding]; other site 940190000647 Mg2+ binding site [ion binding]; other site 940190000648 G-X-G motif; other site 940190000649 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 940190000650 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 940190000651 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 940190000652 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 940190000653 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 940190000654 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 940190000655 Walker A/P-loop; other site 940190000656 ATP binding site [chemical binding]; other site 940190000657 Q-loop/lid; other site 940190000658 ABC transporter signature motif; other site 940190000659 Walker B; other site 940190000660 D-loop; other site 940190000661 H-loop/switch region; other site 940190000662 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 940190000663 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 940190000664 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 940190000665 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 940190000666 TM-ABC transporter signature motif; other site 940190000667 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190000668 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 940190000669 Walker A/P-loop; other site 940190000670 ATP binding site [chemical binding]; other site 940190000671 Q-loop/lid; other site 940190000672 ABC transporter signature motif; other site 940190000673 Walker B; other site 940190000674 D-loop; other site 940190000675 H-loop/switch region; other site 940190000676 inner membrane transport permease; Provisional; Region: PRK15066 940190000677 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 940190000678 GMP synthase; Reviewed; Region: guaA; PRK00074 940190000679 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 940190000680 AMP/PPi binding site [chemical binding]; other site 940190000681 candidate oxyanion hole; other site 940190000682 catalytic triad [active] 940190000683 potential glutamine specificity residues [chemical binding]; other site 940190000684 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 940190000685 ATP Binding subdomain [chemical binding]; other site 940190000686 Dimerization subdomain; other site 940190000687 pantothenate kinase; Provisional; Region: PRK05439 940190000688 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 940190000689 ATP-binding site [chemical binding]; other site 940190000690 CoA-binding site [chemical binding]; other site 940190000691 Mg2+-binding site [ion binding]; other site 940190000692 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 940190000693 active site 940190000694 catalytic triad [active] 940190000695 oxyanion hole [active] 940190000696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190000697 Methyltransferase domain; Region: Methyltransf_31; pfam13847 940190000698 S-adenosylmethionine binding site [chemical binding]; other site 940190000699 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 940190000700 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 940190000701 active site 940190000702 catalytic motif [active] 940190000703 Zn binding site [ion binding]; other site 940190000704 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 940190000705 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 940190000706 ligand binding site [chemical binding]; other site 940190000707 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 940190000708 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 940190000709 Walker A/P-loop; other site 940190000710 ATP binding site [chemical binding]; other site 940190000711 Q-loop/lid; other site 940190000712 ABC transporter signature motif; other site 940190000713 Walker B; other site 940190000714 D-loop; other site 940190000715 H-loop/switch region; other site 940190000716 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 940190000717 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 940190000718 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 940190000719 TM-ABC transporter signature motif; other site 940190000720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 940190000721 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 940190000722 TM-ABC transporter signature motif; other site 940190000723 purine nucleoside phosphorylase; Provisional; Region: PRK08202 940190000724 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 940190000725 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 940190000726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190000727 catalytic core [active] 940190000728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190000729 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 940190000730 tetramer (dimer of dimers) interface [polypeptide binding]; other site 940190000731 active site 940190000732 dimer interface [polypeptide binding]; other site 940190000733 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 940190000734 S17 interaction site [polypeptide binding]; other site 940190000735 S8 interaction site; other site 940190000736 16S rRNA interaction site [nucleotide binding]; other site 940190000737 streptomycin interaction site [chemical binding]; other site 940190000738 23S rRNA interaction site [nucleotide binding]; other site 940190000739 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 940190000740 30S ribosomal protein S7; Validated; Region: PRK05302 940190000741 elongation factor G; Reviewed; Region: PRK00007 940190000742 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 940190000743 G1 box; other site 940190000744 putative GEF interaction site [polypeptide binding]; other site 940190000745 GTP/Mg2+ binding site [chemical binding]; other site 940190000746 Switch I region; other site 940190000747 G2 box; other site 940190000748 G3 box; other site 940190000749 Switch II region; other site 940190000750 G4 box; other site 940190000751 G5 box; other site 940190000752 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 940190000753 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 940190000754 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 940190000755 elongation factor Tu; Reviewed; Region: PRK00049 940190000756 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 940190000757 G1 box; other site 940190000758 GEF interaction site [polypeptide binding]; other site 940190000759 GTP/Mg2+ binding site [chemical binding]; other site 940190000760 Switch I region; other site 940190000761 G2 box; other site 940190000762 G3 box; other site 940190000763 Switch II region; other site 940190000764 G4 box; other site 940190000765 G5 box; other site 940190000766 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 940190000767 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 940190000768 Antibiotic Binding Site [chemical binding]; other site 940190000769 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 940190000770 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 940190000771 catalytic site [active] 940190000772 G-X2-G-X-G-K; other site 940190000773 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 940190000774 proline racemase; Provisional; Region: PRK13969 940190000775 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 940190000776 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 940190000777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190000778 ATP binding site [chemical binding]; other site 940190000779 putative Mg++ binding site [ion binding]; other site 940190000780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190000781 ATP-binding site [chemical binding]; other site 940190000782 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 940190000783 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 940190000784 putative active site [active] 940190000785 substrate binding site [chemical binding]; other site 940190000786 putative cosubstrate binding site; other site 940190000787 catalytic site [active] 940190000788 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 940190000789 substrate binding site [chemical binding]; other site 940190000790 16S rRNA methyltransferase B; Provisional; Region: PRK14902 940190000791 NusB family; Region: NusB; pfam01029 940190000792 putative RNA binding site [nucleotide binding]; other site 940190000793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190000794 S-adenosylmethionine binding site [chemical binding]; other site 940190000795 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 940190000796 active site 940190000797 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 940190000798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 940190000799 active site 940190000800 ATP binding site [chemical binding]; other site 940190000801 substrate binding site [chemical binding]; other site 940190000802 activation loop (A-loop); other site 940190000803 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 940190000804 PASTA domain; Region: PASTA; smart00740 940190000805 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 940190000806 GTPase RsgA; Reviewed; Region: PRK00098 940190000807 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 940190000808 RNA binding site [nucleotide binding]; other site 940190000809 homodimer interface [polypeptide binding]; other site 940190000810 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 940190000811 GTPase/Zn-binding domain interface [polypeptide binding]; other site 940190000812 GTP/Mg2+ binding site [chemical binding]; other site 940190000813 G4 box; other site 940190000814 G5 box; other site 940190000815 G1 box; other site 940190000816 Switch I region; other site 940190000817 G2 box; other site 940190000818 G3 box; other site 940190000819 Switch II region; other site 940190000820 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 940190000821 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 940190000822 substrate binding site [chemical binding]; other site 940190000823 hexamer interface [polypeptide binding]; other site 940190000824 metal binding site [ion binding]; metal-binding site 940190000825 Thiamine pyrophosphokinase; Region: TPK; cd07995 940190000826 active site 940190000827 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 940190000828 dimerization interface [polypeptide binding]; other site 940190000829 thiamine binding site [chemical binding]; other site 940190000830 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 940190000831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 940190000832 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 940190000833 DAK2 domain; Region: Dak2; pfam02734 940190000834 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 940190000835 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 940190000836 generic binding surface II; other site 940190000837 ssDNA binding site; other site 940190000838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190000839 ATP binding site [chemical binding]; other site 940190000840 putative Mg++ binding site [ion binding]; other site 940190000841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190000842 nucleotide binding region [chemical binding]; other site 940190000843 ATP-binding site [chemical binding]; other site 940190000844 putative phosphate acyltransferase; Provisional; Region: PRK05331 940190000845 acyl carrier protein; Provisional; Region: acpP; PRK00982 940190000846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 940190000847 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 940190000848 substrate binding pocket [chemical binding]; other site 940190000849 membrane-bound complex binding site; other site 940190000850 hinge residues; other site 940190000851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190000852 dimer interface [polypeptide binding]; other site 940190000853 conserved gate region; other site 940190000854 putative PBP binding loops; other site 940190000855 ABC-ATPase subunit interface; other site 940190000856 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 940190000857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 940190000858 Walker A/P-loop; other site 940190000859 ATP binding site [chemical binding]; other site 940190000860 Q-loop/lid; other site 940190000861 ABC transporter signature motif; other site 940190000862 Walker B; other site 940190000863 D-loop; other site 940190000864 H-loop/switch region; other site 940190000865 maltose O-acetyltransferase; Provisional; Region: PRK10092 940190000866 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 940190000867 active site 940190000868 substrate binding site [chemical binding]; other site 940190000869 trimer interface [polypeptide binding]; other site 940190000870 CoA binding site [chemical binding]; other site 940190000871 Chorismate mutase type II; Region: CM_2; cl00693 940190000872 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 940190000873 HTH domain; Region: HTH_11; pfam08279 940190000874 3H domain; Region: 3H; pfam02829 940190000875 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 940190000876 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 940190000877 tetramer (dimer of dimers) interface [polypeptide binding]; other site 940190000878 NAD binding site [chemical binding]; other site 940190000879 dimer interface [polypeptide binding]; other site 940190000880 substrate binding site [chemical binding]; other site 940190000881 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 940190000882 putative active site [active] 940190000883 catalytic residue [active] 940190000884 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 940190000885 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 940190000886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190000887 ATP binding site [chemical binding]; other site 940190000888 putative Mg++ binding site [ion binding]; other site 940190000889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190000890 nucleotide binding region [chemical binding]; other site 940190000891 ATP-binding site [chemical binding]; other site 940190000892 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 940190000893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190000894 RNA binding surface [nucleotide binding]; other site 940190000895 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 940190000896 Septum formation initiator; Region: DivIC; pfam04977 940190000897 hypothetical protein; Provisional; Region: PRK08582 940190000898 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 940190000899 RNA binding site [nucleotide binding]; other site 940190000900 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 940190000901 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 940190000902 Ligand Binding Site [chemical binding]; other site 940190000903 TilS substrate C-terminal domain; Region: TilS_C; smart00977 940190000904 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190000905 active site 940190000906 FtsH Extracellular; Region: FtsH_ext; pfam06480 940190000907 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 940190000908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190000909 Walker A motif; other site 940190000910 ATP binding site [chemical binding]; other site 940190000911 Walker B motif; other site 940190000912 arginine finger; other site 940190000913 Peptidase family M41; Region: Peptidase_M41; pfam01434 940190000914 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 940190000915 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 940190000916 dimerization interface [polypeptide binding]; other site 940190000917 domain crossover interface; other site 940190000918 redox-dependent activation switch; other site 940190000919 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 940190000920 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 940190000921 FMN binding site [chemical binding]; other site 940190000922 active site 940190000923 catalytic residues [active] 940190000924 substrate binding site [chemical binding]; other site 940190000925 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 940190000926 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 940190000927 dimer interface [polypeptide binding]; other site 940190000928 putative anticodon binding site; other site 940190000929 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 940190000930 motif 1; other site 940190000931 active site 940190000932 motif 2; other site 940190000933 motif 3; other site 940190000934 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 940190000935 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 940190000936 Clp amino terminal domain; Region: Clp_N; pfam02861 940190000937 Clp amino terminal domain; Region: Clp_N; pfam02861 940190000938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190000939 Walker A motif; other site 940190000940 ATP binding site [chemical binding]; other site 940190000941 Walker B motif; other site 940190000942 arginine finger; other site 940190000943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190000944 Walker A motif; other site 940190000945 ATP binding site [chemical binding]; other site 940190000946 Walker B motif; other site 940190000947 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 940190000948 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 940190000949 Peptidase family U32; Region: Peptidase_U32; pfam01136 940190000950 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 940190000951 Peptidase family U32; Region: Peptidase_U32; pfam01136 940190000952 competence damage-inducible protein A; Provisional; Region: PRK00549 940190000953 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 940190000954 putative MPT binding site; other site 940190000955 Competence-damaged protein; Region: CinA; pfam02464 940190000956 recombinase A; Provisional; Region: recA; PRK09354 940190000957 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 940190000958 hexamer interface [polypeptide binding]; other site 940190000959 Walker A motif; other site 940190000960 ATP binding site [chemical binding]; other site 940190000961 Walker B motif; other site 940190000962 phosphodiesterase; Provisional; Region: PRK12704 940190000963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190000964 Zn2+ binding site [ion binding]; other site 940190000965 Mg2+ binding site [ion binding]; other site 940190000966 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 940190000967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 940190000968 putative active site [active] 940190000969 metal binding site [ion binding]; metal-binding site 940190000970 homodimer binding site [polypeptide binding]; other site 940190000971 Protein of unknown function (DUF964); Region: DUF964; cl01483 940190000972 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 940190000973 MutS domain I; Region: MutS_I; pfam01624 940190000974 MutS domain II; Region: MutS_II; pfam05188 940190000975 MutS domain III; Region: MutS_III; pfam05192 940190000976 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 940190000977 Walker A/P-loop; other site 940190000978 ATP binding site [chemical binding]; other site 940190000979 Q-loop/lid; other site 940190000980 ABC transporter signature motif; other site 940190000981 Walker B; other site 940190000982 D-loop; other site 940190000983 H-loop/switch region; other site 940190000984 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 940190000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190000986 ATP binding site [chemical binding]; other site 940190000987 Mg2+ binding site [ion binding]; other site 940190000988 G-X-G motif; other site 940190000989 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 940190000990 ATP binding site [chemical binding]; other site 940190000991 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 940190000992 methionine sulfoxide reductase B; Provisional; Region: PRK00222 940190000993 SelR domain; Region: SelR; pfam01641 940190000994 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 940190000995 RuvA N terminal domain; Region: RuvA_N; pfam01330 940190000996 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 940190000997 helix-hairpin-helix signature motif; other site 940190000998 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 940190000999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190001000 Walker A motif; other site 940190001001 ATP binding site [chemical binding]; other site 940190001002 Walker B motif; other site 940190001003 arginine finger; other site 940190001004 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 940190001005 ribonuclease III; Reviewed; Region: rnc; PRK00102 940190001006 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 940190001007 dimerization interface [polypeptide binding]; other site 940190001008 active site 940190001009 metal binding site [ion binding]; metal-binding site 940190001010 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 940190001011 dsRNA binding site [nucleotide binding]; other site 940190001012 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 940190001013 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 940190001014 Walker A/P-loop; other site 940190001015 ATP binding site [chemical binding]; other site 940190001016 Q-loop/lid; other site 940190001017 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 940190001018 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 940190001019 ABC transporter signature motif; other site 940190001020 Walker B; other site 940190001021 D-loop; other site 940190001022 H-loop/switch region; other site 940190001023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190001024 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 940190001025 active site 940190001026 motif I; other site 940190001027 motif II; other site 940190001028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190001029 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 940190001030 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 940190001031 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 940190001032 P loop; other site 940190001033 GTP binding site [chemical binding]; other site 940190001034 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 940190001035 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 940190001036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 940190001037 potential frameshift: common BLAST hit: gi|29376659|ref|NP_815813.1| FemAB family protein 940190001038 FemAB family; Region: FemAB; pfam02388 940190001039 FemAB family; Region: FemAB; pfam02388 940190001040 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 940190001041 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190001042 dimer interface [polypeptide binding]; other site 940190001043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 940190001044 putative PBP binding regions; other site 940190001045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190001046 ABC-ATPase subunit interface; other site 940190001047 dimer interface [polypeptide binding]; other site 940190001048 putative PBP binding regions; other site 940190001049 iron compound ABC uptake transporter ATP-binding protein 940190001050 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 940190001051 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 940190001052 putative ligand binding residues [chemical binding]; other site 940190001053 BioY family; Region: BioY; pfam02632 940190001054 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 940190001055 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 940190001056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190001057 RNA binding surface [nucleotide binding]; other site 940190001058 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 940190001059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190001060 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 940190001061 active site 940190001062 motif I; other site 940190001063 motif II; other site 940190001064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190001065 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 940190001066 active site 940190001067 catalytic residues [active] 940190001068 metal binding site [ion binding]; metal-binding site 940190001069 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 940190001070 16S/18S rRNA binding site [nucleotide binding]; other site 940190001071 S13e-L30e interaction site [polypeptide binding]; other site 940190001072 25S rRNA binding site [nucleotide binding]; other site 940190001073 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 940190001074 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 940190001075 RNase E interface [polypeptide binding]; other site 940190001076 trimer interface [polypeptide binding]; other site 940190001077 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 940190001078 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 940190001079 RNase E interface [polypeptide binding]; other site 940190001080 trimer interface [polypeptide binding]; other site 940190001081 active site 940190001082 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 940190001083 putative nucleic acid binding region [nucleotide binding]; other site 940190001084 G-X-X-G motif; other site 940190001085 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 940190001086 RNA binding site [nucleotide binding]; other site 940190001087 domain interface; other site 940190001088 rod shape-determining protein MreC; Provisional; Region: PRK13922 940190001089 rod shape-determining protein MreC; Region: MreC; pfam04085 940190001090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 940190001091 PhoU domain; Region: PhoU; pfam01895 940190001092 CHAP domain; Region: CHAP; cl17642 940190001093 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 940190001094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 940190001095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 940190001096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 940190001097 protein binding site [polypeptide binding]; other site 940190001098 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 940190001099 potential frameshift: common BLAST hit: gi|29377430|ref|NP_816584.1| BglG family transcriptional antiterminator 940190001100 Mga helix-turn-helix domain; Region: Mga; pfam05043 940190001101 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 940190001102 PRD domain; Region: PRD; pfam00874 940190001103 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 940190001104 active site 940190001105 P-loop; other site 940190001106 phosphorylation site [posttranslational modification] 940190001107 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 940190001108 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 940190001109 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 940190001110 active site 940190001111 P-loop; other site 940190001112 phosphorylation site [posttranslational modification] 940190001113 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 940190001114 Uncharacterized conserved protein [Function unknown]; Region: COG3589 940190001115 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 940190001116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 940190001117 active site turn [active] 940190001118 phosphorylation site [posttranslational modification] 940190001119 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 940190001120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 940190001121 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 940190001122 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 940190001123 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 940190001124 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 940190001125 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 940190001126 putative active site [active] 940190001127 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 940190001128 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 940190001129 substrate binding site [chemical binding]; other site 940190001130 dimer interface [polypeptide binding]; other site 940190001131 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 940190001132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 940190001133 ATP binding site [chemical binding]; other site 940190001134 substrate binding site [chemical binding]; other site 940190001135 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 940190001136 HPr interaction site; other site 940190001137 glycerol kinase (GK) interaction site [polypeptide binding]; other site 940190001138 active site 940190001139 phosphorylation site [posttranslational modification] 940190001140 potential frameshift: common BLAST hit: gi|302340645|ref|YP_003805851.1| aldo/keto reductase 940190001141 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 940190001142 catalytic tetrad [active] 940190001143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 940190001144 active site 940190001145 catalytic tetrad [active] 940190001146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 940190001147 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 940190001148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190001149 Domain of unknown function (DUF718); Region: DUF718; cl01281 940190001150 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 940190001151 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 940190001152 Nucleoside recognition; Region: Gate; pfam07670 940190001153 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 940190001154 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 940190001155 active site 940190001156 tetramer interface [polypeptide binding]; other site 940190001157 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 940190001158 MarR family; Region: MarR_2; pfam12802 940190001159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190001160 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190001161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190001162 Walker A/P-loop; other site 940190001163 ATP binding site [chemical binding]; other site 940190001164 Q-loop/lid; other site 940190001165 ABC transporter signature motif; other site 940190001166 Walker B; other site 940190001167 D-loop; other site 940190001168 H-loop/switch region; other site 940190001169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190001170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190001171 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 940190001172 Walker A/P-loop; other site 940190001173 ATP binding site [chemical binding]; other site 940190001174 Q-loop/lid; other site 940190001175 ABC transporter signature motif; other site 940190001176 Walker B; other site 940190001177 D-loop; other site 940190001178 H-loop/switch region; other site 940190001179 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 940190001180 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190001181 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 940190001182 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 940190001183 active site 940190001184 catalytic site [active] 940190001185 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 940190001186 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 940190001187 Ca binding site [ion binding]; other site 940190001188 substrate binding site [chemical binding]; other site 940190001189 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 940190001190 active site 940190001191 catalytic triad [active] 940190001192 oxyanion hole [active] 940190001193 potential frameshift: common BLAST hit: gi|29375098|ref|NP_814251.1| MgtC family protein 940190001194 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 940190001195 MgtC family; Region: MgtC; pfam02308 940190001196 Peptidase family C69; Region: Peptidase_C69; pfam03577 940190001197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 940190001198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190001199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190001200 Walker A/P-loop; other site 940190001201 ATP binding site [chemical binding]; other site 940190001202 Q-loop/lid; other site 940190001203 ABC transporter signature motif; other site 940190001204 Walker B; other site 940190001205 D-loop; other site 940190001206 H-loop/switch region; other site 940190001207 conserved hypothetical integral membrane protein; Region: TIGR03766 940190001208 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 940190001209 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 940190001210 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 940190001211 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 940190001212 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 940190001213 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 940190001214 putative substrate binding site [chemical binding]; other site 940190001215 putative ATP binding site [chemical binding]; other site 940190001216 Class I aldolases; Region: Aldolase_Class_I; cl17187 940190001217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190001218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190001219 Walker A/P-loop; other site 940190001220 ATP binding site [chemical binding]; other site 940190001221 Q-loop/lid; other site 940190001222 ABC transporter signature motif; other site 940190001223 Walker B; other site 940190001224 D-loop; other site 940190001225 H-loop/switch region; other site 940190001226 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 940190001227 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 940190001228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 940190001229 nucleotide binding site [chemical binding]; other site 940190001230 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 940190001231 xylose isomerase; Provisional; Region: PRK05474 940190001232 xylose isomerase; Region: xylose_isom_A; TIGR02630 940190001233 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 940190001234 N- and C-terminal domain interface [polypeptide binding]; other site 940190001235 D-xylulose kinase; Region: XylB; TIGR01312 940190001236 active site 940190001237 MgATP binding site [chemical binding]; other site 940190001238 catalytic site [active] 940190001239 metal binding site [ion binding]; metal-binding site 940190001240 xylulose binding site [chemical binding]; other site 940190001241 homodimer interface [polypeptide binding]; other site 940190001242 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 940190001243 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 940190001244 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 940190001245 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 940190001246 putative dimer interface [polypeptide binding]; other site 940190001247 putative anticodon binding site; other site 940190001248 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 940190001249 homodimer interface [polypeptide binding]; other site 940190001250 motif 1; other site 940190001251 motif 2; other site 940190001252 active site 940190001253 motif 3; other site 940190001254 potential frameshift: common BLAST hit: gi|29375733|ref|NP_814887.1| M20/M25/M40 family peptidase 940190001255 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 940190001256 active site 940190001257 metal binding site [ion binding]; metal-binding site 940190001258 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 940190001259 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 940190001260 active site 940190001261 dimer interface [polypeptide binding]; other site 940190001262 catalytic nucleophile [active] 940190001263 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 940190001264 active site 940190001265 P-loop; other site 940190001266 phosphorylation site [posttranslational modification] 940190001267 potential frameshift: common BLAST hit: gi|331700558|ref|YP_004397517.1| 67 kDa myosin-cross-reactive antigen family protein 940190001268 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 940190001269 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 940190001270 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 940190001271 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 940190001272 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 940190001273 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 940190001274 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 940190001275 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 940190001276 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 940190001277 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 940190001278 potential frameshift: common BLAST hit: gi|29376745|ref|NP_815899.1| LacI family sugar-binding transcriptional regulator 940190001279 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 940190001280 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190001281 putative ligand binding site [chemical binding]; other site 940190001282 putative dimerization interface [polypeptide binding]; other site 940190001283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190001284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 940190001285 DNA binding site [nucleotide binding] 940190001286 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 940190001287 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 940190001288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190001289 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 940190001290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190001291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190001292 dimer interface [polypeptide binding]; other site 940190001293 conserved gate region; other site 940190001294 putative PBP binding loops; other site 940190001295 ABC-ATPase subunit interface; other site 940190001296 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 940190001297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190001298 DNA-binding site [nucleotide binding]; DNA binding site 940190001299 UTRA domain; Region: UTRA; pfam07702 940190001300 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 940190001301 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 940190001302 dimer interface [polypeptide binding]; other site 940190001303 active site 940190001304 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 940190001305 putative active site [active] 940190001306 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 940190001307 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 940190001308 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 940190001309 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 940190001310 active site 940190001311 phosphorylation site [posttranslational modification] 940190001312 potential frameshift: common BLAST hit: gi|29376346|ref|NP_815500.1| PTS system, IID component 940190001313 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 940190001314 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 940190001315 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 940190001316 active pocket/dimerization site; other site 940190001317 active site 940190001318 phosphorylation site [posttranslational modification] 940190001319 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 940190001320 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 940190001321 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 940190001322 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 940190001323 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 940190001324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190001325 DNA-binding site [nucleotide binding]; DNA binding site 940190001326 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 940190001327 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 940190001328 active site turn [active] 940190001329 phosphorylation site [posttranslational modification] 940190001330 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 940190001331 potential frameshift: common BLAST hit: gi|305676670|ref|YP_003868342.1| aryl-6-phospho-beta-glucosidase 940190001332 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 940190001333 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 940190001334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 940190001335 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 940190001336 Walker A/P-loop; other site 940190001337 ATP binding site [chemical binding]; other site 940190001338 Q-loop/lid; other site 940190001339 ABC transporter signature motif; other site 940190001340 Walker B; other site 940190001341 D-loop; other site 940190001342 H-loop/switch region; other site 940190001343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190001344 non-specific DNA binding site [nucleotide binding]; other site 940190001345 salt bridge; other site 940190001346 sequence-specific DNA binding site [nucleotide binding]; other site 940190001347 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 940190001348 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 940190001349 peptide binding site [polypeptide binding]; other site 940190001350 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 940190001351 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 940190001352 active site 940190001353 trimer interface [polypeptide binding]; other site 940190001354 allosteric site; other site 940190001355 active site lid [active] 940190001356 hexamer (dimer of trimers) interface [polypeptide binding]; other site 940190001357 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 940190001358 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 940190001359 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 940190001360 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 940190001361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190001362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190001363 homodimer interface [polypeptide binding]; other site 940190001364 catalytic residue [active] 940190001365 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 940190001366 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 940190001367 active site turn [active] 940190001368 phosphorylation site [posttranslational modification] 940190001369 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 940190001370 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 940190001371 HPr interaction site; other site 940190001372 glycerol kinase (GK) interaction site [polypeptide binding]; other site 940190001373 active site 940190001374 phosphorylation site [posttranslational modification] 940190001375 transcriptional antiterminator BglG; Provisional; Region: PRK09772 940190001376 CAT RNA binding domain; Region: CAT_RBD; smart01061 940190001377 PRD domain; Region: PRD; pfam00874 940190001378 PRD domain; Region: PRD; pfam00874 940190001379 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 940190001380 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 940190001381 Cl- selectivity filter; other site 940190001382 Cl- binding residues [ion binding]; other site 940190001383 pore gating glutamate residue; other site 940190001384 dimer interface [polypeptide binding]; other site 940190001385 H+/Cl- coupling transport residue; other site 940190001386 TrkA-C domain; Region: TrkA_C; pfam02080 940190001387 FemAB family; Region: FemAB; pfam02388 940190001388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 940190001389 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 940190001390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 940190001391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190001392 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 940190001393 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190001394 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190001395 Melibiase; Region: Melibiase; pfam02065 940190001396 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 940190001397 putative metal binding site [ion binding]; other site 940190001398 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 940190001399 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 940190001400 Ca binding site [ion binding]; other site 940190001401 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 940190001402 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 940190001403 dimer interface [polypeptide binding]; other site 940190001404 active site 940190001405 metal binding site [ion binding]; metal-binding site 940190001406 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 940190001407 active site 940190001408 LemA family; Region: LemA; cl00742 940190001409 Repair protein; Region: Repair_PSII; pfam04536 940190001410 potential frameshift: common BLAST hit: gi|163119467|ref|YP_079231.2| sugar transporter 940190001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190001412 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 940190001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190001414 putative substrate translocation pore; other site 940190001415 L-arabinose isomerase; Provisional; Region: PRK02929 940190001416 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 940190001417 hexamer (dimer of trimers) interface [polypeptide binding]; other site 940190001418 trimer interface [polypeptide binding]; other site 940190001419 substrate binding site [chemical binding]; other site 940190001420 Mn binding site [ion binding]; other site 940190001421 XFP N-terminal domain; Region: XFP_N; pfam09364 940190001422 potential frameshift: common BLAST hit: gi|328958427|ref|YP_004375813.1| xylulose-5-phosphate phosphoketolase 940190001423 putative phosphoketolase; Provisional; Region: PRK05261 940190001424 XFP N-terminal domain; Region: XFP_N; pfam09364 940190001425 XFP C-terminal domain; Region: XFP_C; pfam09363 940190001426 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 940190001427 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 940190001428 active site 940190001429 HIGH motif; other site 940190001430 dimer interface [polypeptide binding]; other site 940190001431 KMSKS motif; other site 940190001432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190001433 RNA binding surface [nucleotide binding]; other site 940190001434 decarboxylase 940190001435 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 940190001436 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 940190001437 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 940190001438 active site 940190001439 catalytic triad [active] 940190001440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 940190001441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190001442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 940190001443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190001444 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190001445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190001446 dimer interface [polypeptide binding]; other site 940190001447 conserved gate region; other site 940190001448 putative PBP binding loops; other site 940190001449 ABC-ATPase subunit interface; other site 940190001450 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 940190001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190001452 dimer interface [polypeptide binding]; other site 940190001453 conserved gate region; other site 940190001454 ABC-ATPase subunit interface; other site 940190001455 Protein of unknown function, DUF624; Region: DUF624; cl02369 940190001456 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 940190001457 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 940190001458 putative pectinesterase; Region: PLN02432; cl01911 940190001459 putative pectinesterase; Region: PLN02432; cl01911 940190001460 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 940190001461 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 940190001462 inhibitor binding site; inhibition site 940190001463 active site 940190001464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190001465 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190001466 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 940190001467 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 940190001468 MFS/sugar transport protein; Region: MFS_2; pfam13347 940190001469 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190001470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190001471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 940190001472 DNA binding site [nucleotide binding] 940190001473 domain linker motif; other site 940190001474 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 940190001475 ligand binding site [chemical binding]; other site 940190001476 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 940190001477 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 940190001478 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 940190001479 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 940190001480 galactarate dehydratase; Region: galactar-dH20; TIGR03248 940190001481 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 940190001482 Transcriptional regulators [Transcription]; Region: GntR; COG1802 940190001483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190001484 DNA-binding site [nucleotide binding]; DNA binding site 940190001485 FCD domain; Region: FCD; pfam07729 940190001486 Predicted transcriptional regulator [Transcription]; Region: COG4189 940190001487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 940190001488 dimerization interface [polypeptide binding]; other site 940190001489 putative DNA binding site [nucleotide binding]; other site 940190001490 putative Zn2+ binding site [ion binding]; other site 940190001491 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 940190001492 substrate binding site [chemical binding]; other site 940190001493 active site 940190001494 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 940190001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190001496 dimer interface [polypeptide binding]; other site 940190001497 conserved gate region; other site 940190001498 putative PBP binding loops; other site 940190001499 ABC-ATPase subunit interface; other site 940190001500 GO:0005215; GO:0006810; GO:0016020; multiple sugar ABC transporter, membrane-spanning permease MsmG 940190001501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190001502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 940190001503 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 940190001504 Protein of unknown function, DUF624; Region: DUF624; cl02369 940190001505 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 940190001506 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 940190001507 Histidine kinase; Region: His_kinase; pfam06580 940190001508 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 940190001509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190001510 active site 940190001511 phosphorylation site [posttranslational modification] 940190001512 intermolecular recognition site; other site 940190001513 dimerization interface [polypeptide binding]; other site 940190001514 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 940190001515 potential frameshift: common BLAST hit: gi|29376724|ref|NP_815878.1| alpha-1,2-mannosidase 940190001516 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 940190001517 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 940190001518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190001519 DNA-binding site [nucleotide binding]; DNA binding site 940190001520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190001521 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 940190001522 ligand binding site [chemical binding]; other site 940190001523 dimerization interface [polypeptide binding]; other site 940190001524 Uncharacterized conserved protein [Function unknown]; Region: COG3538 940190001525 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 940190001526 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 940190001527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 940190001528 nucleotide binding site [chemical binding]; other site 940190001529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 940190001530 YceG-like family; Region: YceG; pfam02618 940190001531 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 940190001532 dimerization interface [polypeptide binding]; other site 940190001533 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 940190001534 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 940190001535 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 940190001536 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 940190001537 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 940190001538 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 940190001539 Ligand binding site; other site 940190001540 Putative Catalytic site; other site 940190001541 DXD motif; other site 940190001542 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 940190001543 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 940190001544 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 940190001545 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 940190001546 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 940190001547 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 940190001548 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 940190001549 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 940190001550 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 940190001551 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 940190001552 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 940190001553 Chain length determinant protein; Region: Wzz; cl15801 940190001554 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 940190001555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 940190001556 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 940190001557 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 940190001558 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 940190001559 NAD(P) binding site [chemical binding]; other site 940190001560 homodimer interface [polypeptide binding]; other site 940190001561 substrate binding site [chemical binding]; other site 940190001562 active site 940190001563 Bacterial sugar transferase; Region: Bac_transf; pfam02397 940190001564 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 940190001565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 940190001566 NAD(P) binding site [chemical binding]; other site 940190001567 active site 940190001568 potential frameshift: common BLAST hit: gi|160881625|ref|YP_001560593.1| glycosyl transferase group 1 940190001569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 940190001570 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 940190001571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 940190001572 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 940190001573 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 940190001574 NAD(P) binding site [chemical binding]; other site 940190001575 homodimer interface [polypeptide binding]; other site 940190001576 substrate binding site [chemical binding]; other site 940190001577 active site 940190001578 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 940190001579 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 940190001580 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 940190001581 active site 940190001582 homodimer interface [polypeptide binding]; other site 940190001583 potential frameshift: common BLAST hit: gi|217962754|ref|YP_002341330.1| glycosyltransferase 940190001584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 940190001585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 940190001586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 940190001587 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 940190001588 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190001589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190001590 active site 940190001591 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 940190001592 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 940190001593 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 940190001594 dimer interface [polypeptide binding]; other site 940190001595 putative radical transfer pathway; other site 940190001596 diiron center [ion binding]; other site 940190001597 tyrosyl radical; other site 940190001598 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 940190001599 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 940190001600 Class I ribonucleotide reductase; Region: RNR_I; cd01679 940190001601 active site 940190001602 dimer interface [polypeptide binding]; other site 940190001603 catalytic residues [active] 940190001604 effector binding site; other site 940190001605 R2 peptide binding site; other site 940190001606 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 940190001607 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 940190001608 catalytic residues [active] 940190001609 FeoA domain; Region: FeoA; pfam04023 940190001610 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 940190001611 GO:0001882; GO:0005525; GO:0005622; GO:0015093; GO:0015684; GO:0016021; ferrous iron transport protein B 940190001612 Virus attachment protein p12 family; Region: P12; pfam12669 940190001613 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 940190001614 CAAX protease self-immunity; Region: Abi; pfam02517 940190001615 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 940190001616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 940190001617 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 940190001618 active site 940190001619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190001620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190001621 homodimer interface [polypeptide binding]; other site 940190001622 catalytic residue [active] 940190001623 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 940190001624 general stress protein 13; Validated; Region: PRK08059 940190001625 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 940190001626 RNA binding site [nucleotide binding]; other site 940190001627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 940190001628 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 940190001629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 940190001630 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 940190001631 putative ADP-binding pocket [chemical binding]; other site 940190001632 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 940190001633 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 940190001634 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 940190001635 MarR family; Region: MarR; pfam01047 940190001636 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 940190001637 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 940190001638 dimer interface [polypeptide binding]; other site 940190001639 active site 940190001640 CoA binding pocket [chemical binding]; other site 940190001641 acyl carrier protein; Provisional; Region: acpP; PRK00982 940190001642 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 940190001643 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 940190001644 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 940190001645 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 940190001646 NAD(P) binding site [chemical binding]; other site 940190001647 homotetramer interface [polypeptide binding]; other site 940190001648 homodimer interface [polypeptide binding]; other site 940190001649 active site 940190001650 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 940190001651 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 940190001652 dimer interface [polypeptide binding]; other site 940190001653 active site 940190001654 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 940190001655 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 940190001656 carboxyltransferase (CT) interaction site; other site 940190001657 biotinylation site [posttranslational modification]; other site 940190001658 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 940190001659 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 940190001660 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 940190001661 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 940190001662 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 940190001663 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 940190001664 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 940190001665 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 940190001666 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 940190001667 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 940190001668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190001669 active site 940190001670 motif I; other site 940190001671 motif II; other site 940190001672 GTPase YqeH; Provisional; Region: PRK13796 940190001673 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 940190001674 GTP/Mg2+ binding site [chemical binding]; other site 940190001675 G4 box; other site 940190001676 G5 box; other site 940190001677 G1 box; other site 940190001678 Switch I region; other site 940190001679 G2 box; other site 940190001680 G3 box; other site 940190001681 Switch II region; other site 940190001682 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 940190001683 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 940190001684 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 940190001685 active site 940190001686 (T/H)XGH motif; other site 940190001687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190001688 Zn2+ binding site [ion binding]; other site 940190001689 Mg2+ binding site [ion binding]; other site 940190001690 Oligomerisation domain; Region: Oligomerisation; cl00519 940190001691 Methyltransferase domain; Region: Methyltransf_23; pfam13489 940190001692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190001693 S-adenosylmethionine binding site [chemical binding]; other site 940190001694 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1323 940190001695 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 940190001696 hypothetical protein; Provisional; Region: PRK12378 940190001697 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 940190001698 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 940190001699 Uncharacterized conserved protein [Function unknown]; Region: COG1434 940190001700 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 940190001701 putative active site [active] 940190001702 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 940190001703 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 940190001704 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 940190001705 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 940190001706 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 940190001707 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 940190001708 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 940190001709 active site 940190001710 dimer interface [polypeptide binding]; other site 940190001711 motif 1; other site 940190001712 motif 2; other site 940190001713 motif 3; other site 940190001714 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 940190001715 anticodon binding site; other site 940190001716 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 940190001717 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 940190001718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 940190001719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 940190001720 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 940190001721 potential frameshift: common BLAST hit: gi|301066984|ref|YP_003789007.1| Very conserved membrane protein 940190001722 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 940190001723 Rhomboid family; Region: Rhomboid; pfam01694 940190001724 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 940190001725 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 940190001726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 940190001727 nucleotide binding site [chemical binding]; other site 940190001728 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 940190001729 active site residue [active] 940190001730 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 940190001731 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 940190001732 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 940190001733 galactokinase; Provisional; Region: PRK05322 940190001734 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 940190001735 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 940190001736 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 940190001737 NAD binding site [chemical binding]; other site 940190001738 homodimer interface [polypeptide binding]; other site 940190001739 active site 940190001740 substrate binding site [chemical binding]; other site 940190001741 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 940190001742 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 940190001743 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 940190001744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190001745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 940190001746 DNA binding site [nucleotide binding] 940190001747 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 940190001748 putative ligand binding site [chemical binding]; other site 940190001749 putative dimerization interface [polypeptide binding]; other site 940190001750 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 940190001751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190001752 Walker A motif; other site 940190001753 ATP binding site [chemical binding]; other site 940190001754 Walker B motif; other site 940190001755 arginine finger; other site 940190001756 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 940190001757 hypothetical protein; Validated; Region: PRK00153 940190001758 recombination protein RecR; Reviewed; Region: recR; PRK00076 940190001759 RecR protein; Region: RecR; pfam02132 940190001760 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 940190001761 putative active site [active] 940190001762 putative metal-binding site [ion binding]; other site 940190001763 tetramer interface [polypeptide binding]; other site 940190001764 thymidylate kinase; Validated; Region: tmk; PRK00698 940190001765 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 940190001766 TMP-binding site; other site 940190001767 ATP-binding site [chemical binding]; other site 940190001768 Protein of unknown function (DUF970); Region: DUF970; pfam06153 940190001769 DNA polymerase III subunit delta'; Validated; Region: PRK08058 940190001770 DNA polymerase III subunit delta'; Validated; Region: PRK08485 940190001771 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 940190001772 Protein of unknown function (DUF972); Region: DUF972; pfam06156 940190001773 Predicted methyltransferases [General function prediction only]; Region: COG0313 940190001774 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 940190001775 putative SAM binding site [chemical binding]; other site 940190001776 putative homodimer interface [polypeptide binding]; other site 940190001777 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 940190001778 active site 940190001779 DNA polymerase IV; Validated; Region: PRK02406 940190001780 DNA binding site [nucleotide binding] 940190001781 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 940190001782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 940190001783 FeS/SAM binding site; other site 940190001784 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 940190001785 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 940190001786 ATP cone domain; Region: ATP-cone; pfam03477 940190001787 Class III ribonucleotide reductase; Region: RNR_III; cd01675 940190001788 effector binding site; other site 940190001789 active site 940190001790 Zn binding site [ion binding]; other site 940190001791 glycine loop; other site 940190001792 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190001793 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190001794 Walker A/P-loop; other site 940190001795 ATP binding site [chemical binding]; other site 940190001796 Q-loop/lid; other site 940190001797 ABC transporter signature motif; other site 940190001798 Walker B; other site 940190001799 D-loop; other site 940190001800 H-loop/switch region; other site 940190001801 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 940190001802 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 940190001803 acyl-activating enzyme (AAE) consensus motif; other site 940190001804 AMP binding site [chemical binding]; other site 940190001805 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 940190001806 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 940190001807 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 940190001808 DltD N-terminal region; Region: DltD_N; pfam04915 940190001809 DltD central region; Region: DltD_M; pfam04918 940190001810 DltD C-terminal region; Region: DltD_C; pfam04914 940190001811 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 940190001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190001813 S-adenosylmethionine binding site [chemical binding]; other site 940190001814 Arginine repressor [Transcription]; Region: ArgR; COG1438 940190001815 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 940190001816 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 940190001817 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 940190001818 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 940190001819 active site 940190001820 metal binding site [ion binding]; metal-binding site 940190001821 substrate binding site [chemical binding]; other site 940190001822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 940190001823 potential frameshift: common BLAST hit: gi|29376479|ref|NP_815633.1| sigma-54 dependent DNA-binding response regulator 940190001824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190001825 Walker B motif; other site 940190001826 arginine finger; other site 940190001827 Transcriptional antiterminator [Transcription]; Region: COG3933 940190001828 PRD domain; Region: PRD; pfam00874 940190001829 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 940190001830 active pocket/dimerization site; other site 940190001831 active site 940190001832 phosphorylation site [posttranslational modification] 940190001833 PRD domain; Region: PRD; pfam00874 940190001834 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 940190001835 active site 940190001836 active pocket/dimerization site; other site 940190001837 phosphorylation site [posttranslational modification] 940190001838 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 940190001839 active site 940190001840 phosphorylation site [posttranslational modification] 940190001841 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 940190001842 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 940190001843 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 940190001844 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 940190001845 dimer interface [polypeptide binding]; other site 940190001846 active site 940190001847 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 940190001848 dimer interface [polypeptide binding]; other site 940190001849 active site 940190001850 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 940190001851 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 940190001852 putative active site [active] 940190001853 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 940190001854 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 940190001855 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 940190001856 active site 940190001857 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 940190001858 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 940190001859 putative dimer interface [polypeptide binding]; other site 940190001860 Transglycosylase; Region: Transgly; pfam00912 940190001861 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 940190001862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 940190001863 CsbD-like; Region: CsbD; cl17424 940190001864 hypothetical protein; Provisional; Region: PRK13676 940190001865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190001866 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 940190001867 Walker A motif; other site 940190001868 ATP binding site [chemical binding]; other site 940190001869 Walker B motif; other site 940190001870 arginine finger; other site 940190001871 UvrB/uvrC motif; Region: UVR; pfam02151 940190001872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190001873 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 940190001874 Walker A motif; other site 940190001875 ATP binding site [chemical binding]; other site 940190001876 Walker B motif; other site 940190001877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 940190001878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 940190001879 dimerization domain swap beta strand [polypeptide binding]; other site 940190001880 regulatory protein interface [polypeptide binding]; other site 940190001881 active site 940190001882 regulatory phosphorylation site [posttranslational modification]; other site 940190001883 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 940190001884 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 940190001885 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 940190001886 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 940190001887 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 940190001888 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 940190001889 active site 940190001890 phosphorylation site [posttranslational modification] 940190001891 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 940190001892 active site 940190001893 P-loop; other site 940190001894 phosphorylation site [posttranslational modification] 940190001895 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 940190001896 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 940190001897 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 940190001898 putative substrate binding site [chemical binding]; other site 940190001899 putative ATP binding site [chemical binding]; other site 940190001900 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 940190001901 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 940190001902 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 940190001903 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 940190001904 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 940190001905 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 940190001906 active site 940190001907 Na/Ca binding site [ion binding]; other site 940190001908 catalytic site [active] 940190001909 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 940190001910 Part of AAA domain; Region: AAA_19; pfam13245 940190001911 Family description; Region: UvrD_C_2; pfam13538 940190001912 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 940190001913 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 940190001914 nucleotide binding pocket [chemical binding]; other site 940190001915 K-X-D-G motif; other site 940190001916 catalytic site [active] 940190001917 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 940190001918 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 940190001919 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 940190001920 Dimer interface [polypeptide binding]; other site 940190001921 BRCT sequence motif; other site 940190001922 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 940190001923 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 940190001924 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 940190001925 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 940190001926 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 940190001927 GatB domain; Region: GatB_Yqey; smart00845 940190001928 putative lipid kinase; Reviewed; Region: PRK13055 940190001929 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 940190001930 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 940190001931 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 940190001932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190001933 S-adenosylmethionine binding site [chemical binding]; other site 940190001934 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 940190001935 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 940190001936 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 940190001937 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 940190001938 Walker A/P-loop; other site 940190001939 ATP binding site [chemical binding]; other site 940190001940 Q-loop/lid; other site 940190001941 ABC transporter signature motif; other site 940190001942 Walker B; other site 940190001943 D-loop; other site 940190001944 H-loop/switch region; other site 940190001945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190001946 dimer interface [polypeptide binding]; other site 940190001947 conserved gate region; other site 940190001948 putative PBP binding loops; other site 940190001949 ABC-ATPase subunit interface; other site 940190001950 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 940190001951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 940190001952 substrate binding pocket [chemical binding]; other site 940190001953 membrane-bound complex binding site; other site 940190001954 hinge residues; other site 940190001955 excinuclease ABC subunit B; Provisional; Region: PRK05298 940190001956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190001957 ATP binding site [chemical binding]; other site 940190001958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190001959 nucleotide binding region [chemical binding]; other site 940190001960 ATP-binding site [chemical binding]; other site 940190001961 Ultra-violet resistance protein B; Region: UvrB; pfam12344 940190001962 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 940190001963 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 940190001964 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 940190001965 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 940190001966 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 940190001967 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 940190001968 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 940190001969 phosphate binding site [ion binding]; other site 940190001970 putative substrate binding pocket [chemical binding]; other site 940190001971 dimer interface [polypeptide binding]; other site 940190001972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 940190001973 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 940190001974 Thioredoxin; Region: Thioredoxin_4; pfam13462 940190001975 Clp protease; Region: CLP_protease; pfam00574 940190001976 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 940190001977 oligomer interface [polypeptide binding]; other site 940190001978 active site residues [active] 940190001979 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 940190001980 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 940190001981 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 940190001982 Acyltransferase family; Region: Acyl_transf_3; pfam01757 940190001983 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 940190001984 catalytic triad [active] 940190001985 catalytic triad [active] 940190001986 oxyanion hole [active] 940190001987 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 940190001988 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 940190001989 putative NAD(P) binding site [chemical binding]; other site 940190001990 dimer interface [polypeptide binding]; other site 940190001991 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 940190001992 nudix motif; other site 940190001993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 940190001994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 940190001995 Walker A/P-loop; other site 940190001996 ATP binding site [chemical binding]; other site 940190001997 Q-loop/lid; other site 940190001998 ABC transporter signature motif; other site 940190001999 Walker B; other site 940190002000 D-loop; other site 940190002001 H-loop/switch region; other site 940190002002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 940190002003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 940190002004 substrate binding pocket [chemical binding]; other site 940190002005 membrane-bound complex binding site; other site 940190002006 hinge residues; other site 940190002007 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 940190002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190002009 dimer interface [polypeptide binding]; other site 940190002010 conserved gate region; other site 940190002011 ABC-ATPase subunit interface; other site 940190002012 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 940190002013 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 940190002014 Preprotein translocase subunit; Region: YajC; pfam02699 940190002015 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 940190002016 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 940190002017 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 940190002018 putative catalytic cysteine [active] 940190002019 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 940190002020 putative active site [active] 940190002021 metal binding site [ion binding]; metal-binding site 940190002022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 940190002023 potential frameshift: common BLAST hit: gi|28378079|ref|NP_784971.1| integral membrane protein 940190002024 Predicted membrane protein [Function unknown]; Region: COG1511 940190002025 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 940190002026 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 940190002027 Predicted membrane protein [Function unknown]; Region: COG1511 940190002028 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 940190002029 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 940190002030 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 940190002031 putative active site [active] 940190002032 FMN binding site [chemical binding]; other site 940190002033 putative substrate binding site [chemical binding]; other site 940190002034 homotetramer interface [polypeptide binding]; other site 940190002035 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 940190002036 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 940190002037 diphosphomevalonate decarboxylase; Region: PLN02407 940190002038 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 940190002039 mevalonate kinase; Region: mevalon_kin; TIGR00549 940190002040 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 940190002041 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 940190002042 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 940190002043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 940190002044 peptide binding site [polypeptide binding]; other site 940190002045 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 940190002046 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 940190002047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190002048 dimer interface [polypeptide binding]; other site 940190002049 conserved gate region; other site 940190002050 putative PBP binding loops; other site 940190002051 ABC-ATPase subunit interface; other site 940190002052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 940190002053 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 940190002054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190002055 dimer interface [polypeptide binding]; other site 940190002056 conserved gate region; other site 940190002057 putative PBP binding loops; other site 940190002058 ABC-ATPase subunit interface; other site 940190002059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 940190002060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 940190002061 Walker A/P-loop; other site 940190002062 ATP binding site [chemical binding]; other site 940190002063 Q-loop/lid; other site 940190002064 ABC transporter signature motif; other site 940190002065 Walker B; other site 940190002066 D-loop; other site 940190002067 H-loop/switch region; other site 940190002068 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 940190002069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 940190002070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 940190002071 Walker A/P-loop; other site 940190002072 ATP binding site [chemical binding]; other site 940190002073 Q-loop/lid; other site 940190002074 ABC transporter signature motif; other site 940190002075 Walker B; other site 940190002076 D-loop; other site 940190002077 H-loop/switch region; other site 940190002078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 940190002079 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 940190002080 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 940190002081 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 940190002082 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 940190002083 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 940190002084 23S rRNA binding site [nucleotide binding]; other site 940190002085 L21 binding site [polypeptide binding]; other site 940190002086 L13 binding site [polypeptide binding]; other site 940190002087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190002089 active site 940190002090 phosphorylation site [posttranslational modification] 940190002091 intermolecular recognition site; other site 940190002092 dimerization interface [polypeptide binding]; other site 940190002093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190002094 DNA binding site [nucleotide binding] 940190002095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 940190002096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190002097 dimer interface [polypeptide binding]; other site 940190002098 phosphorylation site [posttranslational modification] 940190002099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190002100 ATP binding site [chemical binding]; other site 940190002101 Mg2+ binding site [ion binding]; other site 940190002102 G-X-G motif; other site 940190002103 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 940190002104 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 940190002105 active site 940190002106 HIGH motif; other site 940190002107 KMSKS motif; other site 940190002108 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 940190002109 tRNA binding surface [nucleotide binding]; other site 940190002110 anticodon binding site; other site 940190002111 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 940190002112 dimer interface [polypeptide binding]; other site 940190002113 putative tRNA-binding site [nucleotide binding]; other site 940190002114 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 940190002115 active site 940190002116 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 940190002117 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 940190002118 putative active site [active] 940190002119 putative metal binding site [ion binding]; other site 940190002120 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 940190002121 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 940190002122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190002123 S-adenosylmethionine binding site [chemical binding]; other site 940190002124 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 940190002125 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 940190002126 Walker A/P-loop; other site 940190002127 ATP binding site [chemical binding]; other site 940190002128 Q-loop/lid; other site 940190002129 ABC transporter signature motif; other site 940190002130 Walker B; other site 940190002131 D-loop; other site 940190002132 H-loop/switch region; other site 940190002133 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 940190002134 active site 940190002135 dimer interfaces [polypeptide binding]; other site 940190002136 catalytic residues [active] 940190002137 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 940190002138 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 940190002139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190002140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190002141 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 940190002142 Walker A/P-loop; other site 940190002143 ATP binding site [chemical binding]; other site 940190002144 Q-loop/lid; other site 940190002145 ABC transporter signature motif; other site 940190002146 Walker B; other site 940190002147 D-loop; other site 940190002148 H-loop/switch region; other site 940190002149 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190002150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190002151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002152 Walker A/P-loop; other site 940190002153 ATP binding site [chemical binding]; other site 940190002154 Q-loop/lid; other site 940190002155 ABC transporter signature motif; other site 940190002156 Walker B; other site 940190002157 D-loop; other site 940190002158 H-loop/switch region; other site 940190002159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 940190002160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 940190002161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190002162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 940190002163 Coenzyme A binding pocket [chemical binding]; other site 940190002164 Tubby C 2; Region: Tub_2; cl02043 940190002165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190002166 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 940190002167 active site 940190002168 motif I; other site 940190002169 motif II; other site 940190002170 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 940190002171 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 940190002172 ligand binding site [chemical binding]; other site 940190002173 active site 940190002174 UGI interface [polypeptide binding]; other site 940190002175 catalytic site [active] 940190002176 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 940190002177 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 940190002178 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 940190002179 active site 940190002180 HIGH motif; other site 940190002181 dimer interface [polypeptide binding]; other site 940190002182 KMSKS motif; other site 940190002183 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 940190002184 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 940190002185 Competence protein CoiA-like family; Region: CoiA; cl11541 940190002186 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 940190002187 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 940190002188 active site 940190002189 Zn binding site [ion binding]; other site 940190002190 Thioredoxin; Region: Thioredoxin_5; pfam13743 940190002191 potential frameshift: common BLAST hit: gi|328957080|ref|YP_004374466.1| RNA/thiamine triphosphatase 940190002192 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 940190002193 putative metal binding residues [ion binding]; other site 940190002194 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 940190002195 putative active site; other site 940190002196 signature motif; other site 940190002197 putative triphosphate binding site [ion binding]; other site 940190002198 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 940190002199 potential frameshift: common BLAST hit: gi|308181020|ref|YP_003925148.1| GTP pyrophosphokinase () 940190002200 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 940190002201 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 940190002202 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 940190002203 ATP-NAD kinase; Region: NAD_kinase; pfam01513 940190002204 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 940190002205 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 940190002206 active site 940190002207 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 940190002208 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 940190002209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190002210 Coenzyme A binding pocket [chemical binding]; other site 940190002211 Protein of unknown function (DUF441); Region: DUF441; pfam04284 940190002212 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 940190002213 ArsC family; Region: ArsC; pfam03960 940190002214 putative catalytic residues [active] 940190002215 thiol/disulfide switch; other site 940190002216 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 940190002217 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 940190002218 Protein of unknown function (DUF464); Region: DUF464; pfam04327 940190002219 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 940190002220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 940190002221 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 940190002222 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 940190002223 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 940190002224 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 940190002225 active site 940190002226 Asp23 family; Region: Asp23; pfam03780 940190002227 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 940190002228 putative RNA binding site [nucleotide binding]; other site 940190002229 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 940190002230 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 940190002231 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 940190002232 homodimer interface [polypeptide binding]; other site 940190002233 NADP binding site [chemical binding]; other site 940190002234 substrate binding site [chemical binding]; other site 940190002235 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 940190002236 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 940190002237 generic binding surface II; other site 940190002238 generic binding surface I; other site 940190002239 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 940190002240 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 940190002241 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 940190002242 substrate binding pocket [chemical binding]; other site 940190002243 chain length determination region; other site 940190002244 substrate-Mg2+ binding site; other site 940190002245 catalytic residues [active] 940190002246 aspartate-rich region 1; other site 940190002247 active site lid residues [active] 940190002248 aspartate-rich region 2; other site 940190002249 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 940190002250 S4 RNA-binding domain; Region: S4; smart00363 940190002251 RNA binding surface [nucleotide binding]; other site 940190002252 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 940190002253 Arginine repressor [Transcription]; Region: ArgR; COG1438 940190002254 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 940190002255 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 940190002256 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 940190002257 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 940190002258 Walker A/P-loop; other site 940190002259 ATP binding site [chemical binding]; other site 940190002260 Q-loop/lid; other site 940190002261 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 940190002262 Q-loop/lid; other site 940190002263 ABC transporter signature motif; other site 940190002264 Walker B; other site 940190002265 D-loop; other site 940190002266 H-loop/switch region; other site 940190002267 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 940190002268 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 940190002269 Cl binding site [ion binding]; other site 940190002270 oligomer interface [polypeptide binding]; other site 940190002271 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 940190002272 cell division protein MraZ; Reviewed; Region: PRK00326 940190002273 MraZ protein; Region: MraZ; pfam02381 940190002274 MraZ protein; Region: MraZ; pfam02381 940190002275 MraW methylase family; Region: Methyltransf_5; pfam01795 940190002276 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 940190002277 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 940190002278 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 940190002279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 940190002280 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 940190002281 Mg++ binding site [ion binding]; other site 940190002282 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 940190002283 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 940190002284 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 940190002285 NAD binding site [chemical binding]; other site 940190002286 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190002287 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 940190002288 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 940190002289 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 940190002290 active site 940190002291 homodimer interface [polypeptide binding]; other site 940190002292 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 940190002293 Cell division protein FtsQ; Region: FtsQ; pfam03799 940190002294 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 940190002295 Cell division protein FtsA; Region: FtsA; smart00842 940190002296 Cell division protein FtsA; Region: FtsA; pfam14450 940190002297 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 940190002298 cell division protein FtsZ; Validated; Region: PRK09330 940190002299 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 940190002300 nucleotide binding site [chemical binding]; other site 940190002301 SulA interaction site; other site 940190002302 Protein of unknown function (DUF552); Region: DUF552; pfam04472 940190002303 YGGT family; Region: YGGT; pfam02325 940190002304 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 940190002305 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190002306 RNA binding surface [nucleotide binding]; other site 940190002307 DivIVA protein; Region: DivIVA; pfam05103 940190002308 DivIVA domain; Region: DivI1A_domain; TIGR03544 940190002309 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 940190002310 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 940190002311 active site 940190002312 HIGH motif; other site 940190002313 nucleotide binding site [chemical binding]; other site 940190002314 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 940190002315 active site 940190002316 KMSKS motif; other site 940190002317 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 940190002318 tRNA binding surface [nucleotide binding]; other site 940190002319 anticodon binding site; other site 940190002320 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 940190002321 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 940190002322 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 940190002323 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 940190002324 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 940190002325 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 940190002326 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 940190002327 FeoA domain; Region: FeoA; pfam04023 940190002328 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 940190002329 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 940190002330 DEAD-like helicases superfamily; Region: DEXDc; smart00487 940190002331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 940190002332 ATP binding site [chemical binding]; other site 940190002333 putative Mg++ binding site [ion binding]; other site 940190002334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190002335 nucleotide binding region [chemical binding]; other site 940190002336 ATP-binding site [chemical binding]; other site 940190002337 potential frameshift: common BLAST hit: gi|29375591|ref|NP_814745.1| sigma-54 factor interaction domain-containing protein 940190002338 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 940190002339 potential frameshift: common BLAST hit: gi|29375591|ref|NP_814745.1| sigma-54 factor interaction domain-containing protein 940190002340 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 940190002341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190002342 Walker B motif; other site 940190002343 arginine finger; other site 940190002344 PRD domain; Region: PRD; pfam00874 940190002345 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 940190002346 active pocket/dimerization site; other site 940190002347 active site 940190002348 PRD domain; Region: PRD; pfam00874 940190002349 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 940190002350 active site 940190002351 P-loop; other site 940190002352 phosphorylation site [posttranslational modification] 940190002353 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 940190002354 active site 940190002355 methionine cluster; other site 940190002356 phosphorylation site [posttranslational modification] 940190002357 metal binding site [ion binding]; metal-binding site 940190002358 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 940190002359 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 940190002360 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 940190002361 beta-galactosidase; Region: BGL; TIGR03356 940190002362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 940190002363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 940190002364 WHG domain; Region: WHG; pfam13305 940190002365 flavodoxin; Validated; Region: PRK07308 940190002366 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 940190002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190002368 putative substrate translocation pore; other site 940190002369 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 940190002370 active site 940190002371 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 940190002372 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 940190002373 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 940190002374 Mg++ binding site [ion binding]; other site 940190002375 putative catalytic motif [active] 940190002376 substrate binding site [chemical binding]; other site 940190002377 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 940190002378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190002379 active site 940190002380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190002381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190002382 active site 940190002383 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190002384 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 940190002385 Probable Catalytic site; other site 940190002386 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 940190002387 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 940190002388 substrate binding site; other site 940190002389 tetramer interface; other site 940190002390 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 940190002391 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 940190002392 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 940190002393 NAD binding site [chemical binding]; other site 940190002394 substrate binding site [chemical binding]; other site 940190002395 homodimer interface [polypeptide binding]; other site 940190002396 active site 940190002397 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 940190002398 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 940190002399 NADP binding site [chemical binding]; other site 940190002400 active site 940190002401 putative substrate binding site [chemical binding]; other site 940190002402 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190002403 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 940190002404 Ligand binding site; other site 940190002405 Putative Catalytic site; other site 940190002406 DXD motif; other site 940190002407 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 940190002408 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 940190002409 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 940190002410 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 940190002411 Walker A/P-loop; other site 940190002412 ATP binding site [chemical binding]; other site 940190002413 Q-loop/lid; other site 940190002414 ABC transporter signature motif; other site 940190002415 Walker B; other site 940190002416 D-loop; other site 940190002417 H-loop/switch region; other site 940190002418 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 940190002419 putative carbohydrate binding site [chemical binding]; other site 940190002420 glycosyl transferase, group 2 family protein 940190002421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190002422 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190002423 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 940190002424 Probable Catalytic site; other site 940190002425 metal-binding site 940190002426 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 940190002427 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 940190002428 Probable Catalytic site; other site 940190002429 metal-binding site 940190002430 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 940190002431 Bacterial sugar transferase; Region: Bac_transf; pfam02397 940190002432 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190002433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 940190002434 active site 940190002435 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 940190002436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 940190002437 active site 940190002438 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 940190002439 substrate binding site; other site 940190002440 dimer interface; other site 940190002441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 940190002442 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 940190002443 NAD(P) binding site [chemical binding]; other site 940190002444 active site 940190002445 O-Antigen ligase; Region: Wzy_C; pfam04932 940190002446 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 940190002447 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 940190002448 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 940190002449 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 940190002450 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 940190002451 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 940190002452 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 940190002453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 940190002454 NAD(P) binding site [chemical binding]; other site 940190002455 active site 940190002456 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 940190002457 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 940190002458 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 940190002459 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 940190002460 HflX GTPase family; Region: HflX; cd01878 940190002461 G1 box; other site 940190002462 GTP/Mg2+ binding site [chemical binding]; other site 940190002463 Switch I region; other site 940190002464 G2 box; other site 940190002465 G3 box; other site 940190002466 Switch II region; other site 940190002467 G4 box; other site 940190002468 G5 box; other site 940190002469 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 940190002470 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 940190002471 DNA binding residues [nucleotide binding] 940190002472 putative dimer interface [polypeptide binding]; other site 940190002473 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 940190002474 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 940190002475 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 940190002476 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 940190002477 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 940190002478 dimer interface [polypeptide binding]; other site 940190002479 PYR/PP interface [polypeptide binding]; other site 940190002480 TPP binding site [chemical binding]; other site 940190002481 substrate binding site [chemical binding]; other site 940190002482 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 940190002483 Domain of unknown function; Region: EKR; cl11037 940190002484 4Fe-4S binding domain; Region: Fer4; pfam00037 940190002485 4Fe-4S binding domain; Region: Fer4; pfam00037 940190002486 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 940190002487 TPP-binding site [chemical binding]; other site 940190002488 dimer interface [polypeptide binding]; other site 940190002489 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 940190002490 Uncharacterized conserved protein [Function unknown]; Region: COG1624 940190002491 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 940190002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 940190002493 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 940190002494 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 940190002495 active site 940190002496 substrate binding site [chemical binding]; other site 940190002497 metal binding site [ion binding]; metal-binding site 940190002498 hypothetical protein; Provisional; Region: PRK13661 940190002499 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 940190002500 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 940190002501 Walker A/P-loop; other site 940190002502 ATP binding site [chemical binding]; other site 940190002503 Q-loop/lid; other site 940190002504 ABC transporter signature motif; other site 940190002505 Walker B; other site 940190002506 D-loop; other site 940190002507 H-loop/switch region; other site 940190002508 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 940190002509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 940190002510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 940190002511 Walker A/P-loop; other site 940190002512 ATP binding site [chemical binding]; other site 940190002513 Q-loop/lid; other site 940190002514 ABC transporter signature motif; other site 940190002515 Walker B; other site 940190002516 D-loop; other site 940190002517 H-loop/switch region; other site 940190002518 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 940190002519 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 940190002520 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 940190002521 glutaminase active site [active] 940190002522 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 940190002523 dimer interface [polypeptide binding]; other site 940190002524 active site 940190002525 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 940190002526 dimer interface [polypeptide binding]; other site 940190002527 active site 940190002528 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 940190002529 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 940190002530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002531 Walker A/P-loop; other site 940190002532 ATP binding site [chemical binding]; other site 940190002533 Q-loop/lid; other site 940190002534 ABC transporter signature motif; other site 940190002535 Walker B; other site 940190002536 D-loop; other site 940190002537 H-loop/switch region; other site 940190002538 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 940190002539 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 940190002540 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 940190002541 Methyltransferase domain; Region: Methyltransf_11; pfam08241 940190002542 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 940190002543 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 940190002544 dimer interface [polypeptide binding]; other site 940190002545 ADP-ribose binding site [chemical binding]; other site 940190002546 active site 940190002547 nudix motif; other site 940190002548 metal binding site [ion binding]; metal-binding site 940190002549 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 940190002550 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 940190002551 Isochorismatase family; Region: Isochorismatase; pfam00857 940190002552 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 940190002553 catalytic triad [active] 940190002554 conserved cis-peptide bond; other site 940190002555 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 940190002556 GIY-YIG motif/motif A; other site 940190002557 putative active site [active] 940190002558 putative metal binding site [ion binding]; other site 940190002559 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 940190002560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190002561 S-adenosylmethionine binding site [chemical binding]; other site 940190002562 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 940190002563 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 940190002564 active site 940190002565 metal binding site [ion binding]; metal-binding site 940190002566 DNA binding site [nucleotide binding] 940190002567 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 940190002568 potential frameshift: common BLAST hit: gi|29377169|ref|NP_816323.1| exonuclease SbcC 940190002569 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 940190002570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002571 Walker A/P-loop; other site 940190002572 ATP binding site [chemical binding]; other site 940190002573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002574 Q-loop/lid; other site 940190002575 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 940190002576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002577 ABC transporter signature motif; other site 940190002578 Walker B; other site 940190002579 D-loop; other site 940190002580 H-loop/switch region; other site 940190002581 SWIM zinc finger; Region: SWIM; pfam04434 940190002582 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 940190002583 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 940190002584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190002585 ATP binding site [chemical binding]; other site 940190002586 putative Mg++ binding site [ion binding]; other site 940190002587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190002588 nucleotide binding region [chemical binding]; other site 940190002589 ATP-binding site [chemical binding]; other site 940190002590 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 940190002591 Beta-lactamase; Region: Beta-lactamase; pfam00144 940190002592 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 940190002593 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 940190002594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190002595 active site 940190002596 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 940190002597 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 940190002598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 940190002599 catalytic residue [active] 940190002600 Putative amino acid metabolism; Region: DUF1831; pfam08866 940190002601 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 940190002602 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 940190002603 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 940190002604 DNA topoisomerase III; Provisional; Region: PRK07726 940190002605 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 940190002606 active site 940190002607 putative interdomain interaction site [polypeptide binding]; other site 940190002608 putative metal-binding site [ion binding]; other site 940190002609 putative nucleotide binding site [chemical binding]; other site 940190002610 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 940190002611 domain I; other site 940190002612 DNA binding groove [nucleotide binding] 940190002613 phosphate binding site [ion binding]; other site 940190002614 domain II; other site 940190002615 domain III; other site 940190002616 nucleotide binding site [chemical binding]; other site 940190002617 catalytic site [active] 940190002618 domain IV; other site 940190002619 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 940190002620 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 940190002621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 940190002622 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 940190002623 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 940190002624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 940190002625 FeS/SAM binding site; other site 940190002626 Phosphotransferase enzyme family; Region: APH; pfam01636 940190002627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 940190002628 active site 940190002629 substrate binding site [chemical binding]; other site 940190002630 ATP binding site [chemical binding]; other site 940190002631 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 940190002632 substrate binding site [chemical binding]; other site 940190002633 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 940190002634 magnesium-transporting ATPase; Provisional; Region: PRK15122 940190002635 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190002636 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 940190002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190002638 motif II; other site 940190002639 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 940190002640 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 940190002641 Clp amino terminal domain; Region: Clp_N; pfam02861 940190002642 Clp amino terminal domain; Region: Clp_N; pfam02861 940190002643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190002644 Walker A motif; other site 940190002645 ATP binding site [chemical binding]; other site 940190002646 Walker B motif; other site 940190002647 arginine finger; other site 940190002648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190002649 Walker A motif; other site 940190002650 ATP binding site [chemical binding]; other site 940190002651 Walker B motif; other site 940190002652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 940190002653 Uncharacterized conserved protein [Function unknown]; Region: COG1284 940190002654 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190002655 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190002656 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 940190002657 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 940190002658 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 940190002659 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 940190002660 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 940190002661 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 940190002662 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 940190002663 Phosphoglycerate kinase; Region: PGK; pfam00162 940190002664 substrate binding site [chemical binding]; other site 940190002665 hinge regions; other site 940190002666 ADP binding site [chemical binding]; other site 940190002667 catalytic site [active] 940190002668 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 940190002669 triosephosphate isomerase; Provisional; Region: PRK14565 940190002670 substrate binding site [chemical binding]; other site 940190002671 dimer interface [polypeptide binding]; other site 940190002672 catalytic triad [active] 940190002673 enolase; Provisional; Region: eno; PRK00077 940190002674 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 940190002675 dimer interface [polypeptide binding]; other site 940190002676 metal binding site [ion binding]; metal-binding site 940190002677 substrate binding pocket [chemical binding]; other site 940190002678 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 940190002679 Predicted acetyltransferase [General function prediction only]; Region: COG2388 940190002680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190002681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 940190002682 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 940190002683 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 940190002684 N- and C-terminal domain interface [polypeptide binding]; other site 940190002685 active site 940190002686 catalytic site [active] 940190002687 metal binding site [ion binding]; metal-binding site 940190002688 carbohydrate binding site [chemical binding]; other site 940190002689 ATP binding site [chemical binding]; other site 940190002690 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 940190002691 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 940190002692 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190002693 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 940190002694 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190002695 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 940190002696 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 940190002697 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 940190002698 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 940190002699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190002700 Walker A motif; other site 940190002701 ATP binding site [chemical binding]; other site 940190002702 Walker B motif; other site 940190002703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 940190002704 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 940190002705 G1 box; other site 940190002706 GTP/Mg2+ binding site [chemical binding]; other site 940190002707 Switch I region; other site 940190002708 G2 box; other site 940190002709 G3 box; other site 940190002710 Switch II region; other site 940190002711 G4 box; other site 940190002712 G5 box; other site 940190002713 Haemolytic domain; Region: Haemolytic; pfam01809 940190002714 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 940190002715 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 940190002716 nucleotide binding site [chemical binding]; other site 940190002717 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 940190002718 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 940190002719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 940190002720 catalytic residue [active] 940190002721 L-aspartate oxidase; Region: nadB; TIGR00551 940190002722 L-aspartate oxidase; Provisional; Region: PRK06175 940190002723 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 940190002724 potential frameshift: common BLAST hit: gi|226224621|ref|YP_002758728.1| nicotinate-nucleotide pyrophosphorylase 940190002725 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 940190002726 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 940190002727 active site 940190002728 dimerization interface [polypeptide binding]; other site 940190002729 quinolinate synthetase; Provisional; Region: PRK09375 940190002730 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 940190002731 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 940190002732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 940190002733 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 940190002734 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 940190002735 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 940190002736 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 940190002737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 940190002738 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 940190002739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 940190002740 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 940190002741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190002742 DNA-binding site [nucleotide binding]; DNA binding site 940190002743 UTRA domain; Region: UTRA; pfam07702 940190002744 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 940190002745 classical (c) SDRs; Region: SDR_c; cd05233 940190002746 NAD(P) binding site [chemical binding]; other site 940190002747 active site 940190002748 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 940190002749 Uncharacterized conserved protein [Function unknown]; Region: COG1739 940190002750 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 940190002751 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 940190002752 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 940190002753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190002754 ATP binding site [chemical binding]; other site 940190002755 putative Mg++ binding site [ion binding]; other site 940190002756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190002757 nucleotide binding region [chemical binding]; other site 940190002758 ATP-binding site [chemical binding]; other site 940190002759 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 940190002760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190002761 active site 940190002762 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 940190002763 30S subunit binding site; other site 940190002764 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 940190002765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 940190002766 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 940190002767 nucleotide binding region [chemical binding]; other site 940190002768 helicase superfamily c-terminal domain; Region: HELICc; smart00490 940190002769 ATP-binding site [chemical binding]; other site 940190002770 SEC-C motif; Region: SEC-C; pfam02810 940190002771 peptide chain release factor 2; Provisional; Region: PRK06746 940190002772 This domain is found in peptide chain release factors; Region: PCRF; smart00937 940190002773 RF-1 domain; Region: RF-1; pfam00472 940190002774 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 940190002775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002776 Walker A/P-loop; other site 940190002777 ATP binding site [chemical binding]; other site 940190002778 Q-loop/lid; other site 940190002779 ABC transporter signature motif; other site 940190002780 Walker B; other site 940190002781 D-loop; other site 940190002782 H-loop/switch region; other site 940190002783 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 940190002784 FtsX-like permease family; Region: FtsX; pfam02687 940190002785 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 940190002786 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 940190002787 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 940190002788 putative active site [active] 940190002789 catalytic site [active] 940190002790 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 940190002791 putative active site [active] 940190002792 catalytic site [active] 940190002793 phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) 940190002794 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 940190002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190002796 dimer interface [polypeptide binding]; other site 940190002797 conserved gate region; other site 940190002798 putative PBP binding loops; other site 940190002799 ABC-ATPase subunit interface; other site 940190002800 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 940190002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190002802 dimer interface [polypeptide binding]; other site 940190002803 conserved gate region; other site 940190002804 putative PBP binding loops; other site 940190002805 ABC-ATPase subunit interface; other site 940190002806 potential frameshift: common BLAST hit: gi|29376305|ref|NP_815459.1| phosphate transporter ATP-binding protein 940190002807 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 940190002808 Walker A/P-loop; other site 940190002809 ATP binding site [chemical binding]; other site 940190002810 ABC transporter; Region: ABC_tran; pfam00005 940190002811 Q-loop/lid; other site 940190002812 ABC transporter signature motif; other site 940190002813 Walker B; other site 940190002814 D-loop; other site 940190002815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190002816 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 940190002817 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 940190002818 Walker A/P-loop; other site 940190002819 ATP binding site [chemical binding]; other site 940190002820 Q-loop/lid; other site 940190002821 ABC transporter signature motif; other site 940190002822 Walker B; other site 940190002823 D-loop; other site 940190002824 H-loop/switch region; other site 940190002825 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 940190002826 PhoU domain; Region: PhoU; pfam01895 940190002827 PhoU domain; Region: PhoU; pfam01895 940190002828 PspC domain; Region: PspC; pfam04024 940190002829 Membrane protein of unknown function; Region: DUF360; pfam04020 940190002830 HPr kinase/phosphorylase; Provisional; Region: PRK05428 940190002831 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 940190002832 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 940190002833 Hpr binding site; other site 940190002834 active site 940190002835 homohexamer subunit interaction site [polypeptide binding]; other site 940190002836 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 940190002837 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 940190002838 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 940190002839 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 940190002840 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 940190002841 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 940190002842 active site 940190002843 tetramer interface; other site 940190002844 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 940190002845 YtxH-like protein; Region: YtxH; pfam12732 940190002846 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 940190002847 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 940190002848 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 940190002849 active site 940190002850 catabolite control protein A; Region: ccpA; TIGR01481 940190002851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 940190002852 DNA binding site [nucleotide binding] 940190002853 domain linker motif; other site 940190002854 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 940190002855 dimerization interface [polypeptide binding]; other site 940190002856 effector binding site; other site 940190002857 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 940190002858 Transglycosylase; Region: Transgly; pfam00912 940190002859 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 940190002860 endonuclease IV; Provisional; Region: PRK01060 940190002861 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 940190002862 AP (apurinic/apyrimidinic) site pocket; other site 940190002863 DNA interaction; other site 940190002864 Metal-binding active site; metal-binding site 940190002865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 940190002866 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 940190002867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 940190002868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 940190002869 potential frameshift: common BLAST hit: gi|29375919|ref|NP_815073.1| magnesium-translocating P-type ATPase 940190002870 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 940190002871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190002872 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 940190002873 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 940190002874 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 940190002875 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 940190002876 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 940190002877 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 940190002878 TPP-binding site [chemical binding]; other site 940190002879 tetramer interface [polypeptide binding]; other site 940190002880 heterodimer interface [polypeptide binding]; other site 940190002881 phosphorylation loop region [posttranslational modification] 940190002882 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 940190002883 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 940190002884 alpha subunit interface [polypeptide binding]; other site 940190002885 TPP binding site [chemical binding]; other site 940190002886 heterodimer interface [polypeptide binding]; other site 940190002887 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 940190002888 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 940190002889 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 940190002890 E3 interaction surface; other site 940190002891 lipoyl attachment site [posttranslational modification]; other site 940190002892 e3 binding domain; Region: E3_binding; pfam02817 940190002893 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 940190002894 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 940190002895 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 940190002896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 940190002897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 940190002898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 940190002899 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 940190002900 DNA-binding site [nucleotide binding]; DNA binding site 940190002901 RNA-binding motif; other site 940190002902 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 940190002903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 940190002904 DNA-binding site [nucleotide binding]; DNA binding site 940190002905 DRTGG domain; Region: DRTGG; pfam07085 940190002906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 940190002907 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 940190002908 active site 2 [active] 940190002909 active site 1 [active] 940190002910 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 940190002911 DHH family; Region: DHH; pfam01368 940190002912 DHHA1 domain; Region: DHHA1; pfam02272 940190002913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 940190002914 DEAD-like helicases superfamily; Region: DEXDc; smart00487 940190002915 ATP binding site [chemical binding]; other site 940190002916 putative Mg++ binding site [ion binding]; other site 940190002917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190002918 nucleotide binding region [chemical binding]; other site 940190002919 ATP-binding site [chemical binding]; other site 940190002920 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 940190002921 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 940190002922 motif 1; other site 940190002923 active site 940190002924 motif 2; other site 940190002925 motif 3; other site 940190002926 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 940190002927 DHHA1 domain; Region: DHHA1; pfam02272 940190002928 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 940190002929 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 940190002930 potential frameshift: common BLAST hit: gi|29376714|ref|NP_815868.1| Fis family DNA-binding protein 940190002931 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 940190002932 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 940190002933 nucleoside/Zn binding site; other site 940190002934 dimer interface [polypeptide binding]; other site 940190002935 catalytic motif [active] 940190002936 Chitin binding domain; Region: Chitin_bind_3; pfam03067 940190002937 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 940190002938 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 940190002939 Ca binding site [ion binding]; other site 940190002940 active site 940190002941 catalytic site [active] 940190002942 aminotransferase AlaT; Validated; Region: PRK09265 940190002943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190002944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190002945 homodimer interface [polypeptide binding]; other site 940190002946 catalytic residue [active] 940190002947 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 940190002948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190002949 non-specific DNA binding site [nucleotide binding]; other site 940190002950 salt bridge; other site 940190002951 sequence-specific DNA binding site [nucleotide binding]; other site 940190002952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 940190002953 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 940190002954 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 940190002955 active site 940190002956 dimer interface [polypeptide binding]; other site 940190002957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190002958 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190002959 Walker A/P-loop; other site 940190002960 ATP binding site [chemical binding]; other site 940190002961 Q-loop/lid; other site 940190002962 ABC transporter signature motif; other site 940190002963 Walker B; other site 940190002964 D-loop; other site 940190002965 H-loop/switch region; other site 940190002966 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 940190002967 FtsX-like permease family; Region: FtsX; pfam02687 940190002968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 940190002969 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 940190002970 FtsX-like permease family; Region: FtsX; pfam02687 940190002971 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 940190002972 Family of unknown function (DUF633); Region: DUF633; pfam04816 940190002973 Uncharacterized conserved protein [Function unknown]; Region: COG0327 940190002974 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 940190002975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 940190002976 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 940190002977 Uncharacterized conserved protein [Function unknown]; Region: COG0327 940190002978 peptidase T; Region: peptidase-T; TIGR01882 940190002979 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 940190002980 metal binding site [ion binding]; metal-binding site 940190002981 dimer interface [polypeptide binding]; other site 940190002982 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 940190002983 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 940190002984 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 940190002985 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 940190002986 substrate binding site [chemical binding]; other site 940190002987 multimerization interface [polypeptide binding]; other site 940190002988 ATP binding site [chemical binding]; other site 940190002989 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 940190002990 dimer interface [polypeptide binding]; other site 940190002991 substrate binding site [chemical binding]; other site 940190002992 ATP binding site [chemical binding]; other site 940190002993 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 940190002994 thiamine phosphate binding site [chemical binding]; other site 940190002995 active site 940190002996 pyrophosphate binding site [ion binding]; other site 940190002997 potential frameshift: common BLAST hit: gi|29375967|ref|NP_815121.1| cadmium-translocating P-type ATPase 940190002998 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 940190002999 metal-binding site [ion binding] 940190003000 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 940190003001 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190003002 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190003003 Cell division protein ZapA; Region: ZapA; cl01146 940190003004 Colicin V production protein; Region: Colicin_V; pfam02674 940190003005 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 940190003006 MutS domain III; Region: MutS_III; pfam05192 940190003007 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 940190003008 Walker A/P-loop; other site 940190003009 ATP binding site [chemical binding]; other site 940190003010 Q-loop/lid; other site 940190003011 ABC transporter signature motif; other site 940190003012 Walker B; other site 940190003013 D-loop; other site 940190003014 H-loop/switch region; other site 940190003015 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 940190003016 Smr domain; Region: Smr; pfam01713 940190003017 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 940190003018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 940190003019 catalytic residues [active] 940190003020 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 940190003021 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 940190003022 GIY-YIG motif/motif A; other site 940190003023 active site 940190003024 catalytic site [active] 940190003025 putative DNA binding site [nucleotide binding]; other site 940190003026 metal binding site [ion binding]; metal-binding site 940190003027 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 940190003028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 940190003029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 940190003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190003031 dimer interface [polypeptide binding]; other site 940190003032 conserved gate region; other site 940190003033 putative PBP binding loops; other site 940190003034 ABC-ATPase subunit interface; other site 940190003035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190003037 dimer interface [polypeptide binding]; other site 940190003038 conserved gate region; other site 940190003039 putative PBP binding loops; other site 940190003040 ABC-ATPase subunit interface; other site 940190003041 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 940190003042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190003043 Walker A/P-loop; other site 940190003044 ATP binding site [chemical binding]; other site 940190003045 Q-loop/lid; other site 940190003046 ABC transporter signature motif; other site 940190003047 Walker B; other site 940190003048 D-loop; other site 940190003049 H-loop/switch region; other site 940190003050 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 940190003051 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 940190003052 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 940190003053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190003055 homodimer interface [polypeptide binding]; other site 940190003056 catalytic residue [active] 940190003057 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 940190003058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 940190003059 active site 940190003060 dimer interface [polypeptide binding]; other site 940190003061 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 940190003062 dimer interface [polypeptide binding]; other site 940190003063 active site 940190003064 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 940190003065 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 940190003066 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 940190003067 Catalytic site [active] 940190003068 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 940190003069 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 940190003070 potential frameshift: common BLAST hit: gi|29375689|ref|NP_814843.1| exonuclease RexA 940190003071 Part of AAA domain; Region: AAA_19; pfam13245 940190003072 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 940190003073 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 940190003074 Family description; Region: UvrD_C_2; pfam13538 940190003075 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 940190003076 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 940190003077 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 940190003078 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 940190003079 dimer interface [polypeptide binding]; other site 940190003080 motif 1; other site 940190003081 active site 940190003082 motif 2; other site 940190003083 motif 3; other site 940190003084 glutamate racemase; Provisional; Region: PRK00865 940190003085 ribonuclease PH; Reviewed; Region: rph; PRK00173 940190003086 Ribonuclease PH; Region: RNase_PH_bact; cd11362 940190003087 hexamer interface [polypeptide binding]; other site 940190003088 active site 940190003089 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 940190003090 active site 940190003091 dimerization interface [polypeptide binding]; other site 940190003092 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 940190003093 active site 940190003094 metal binding site [ion binding]; metal-binding site 940190003095 homotetramer interface [polypeptide binding]; other site 940190003096 FOG: CBS domain [General function prediction only]; Region: COG0517 940190003097 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 940190003098 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 940190003099 Mechanosensitive ion channel; Region: MS_channel; pfam00924 940190003100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 940190003101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 940190003102 active site 940190003103 catalytic tetrad [active] 940190003104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 940190003105 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 940190003106 dimer interface [polypeptide binding]; other site 940190003107 active site 940190003108 metal binding site [ion binding]; metal-binding site 940190003109 glutathione binding site [chemical binding]; other site 940190003110 sugar phosphate phosphatase; Provisional; Region: PRK10513 940190003111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190003112 active site 940190003113 motif I; other site 940190003114 motif II; other site 940190003115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 940190003116 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 940190003117 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190003118 Zn2+ binding site [ion binding]; other site 940190003119 Mg2+ binding site [ion binding]; other site 940190003120 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 940190003121 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 940190003122 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 940190003123 putative phosphoketolase; Provisional; Region: PRK05261 940190003124 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 940190003125 TPP-binding site; other site 940190003126 XFP C-terminal domain; Region: XFP_C; pfam09363 940190003127 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 940190003128 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 940190003129 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 940190003130 CTP synthetase; Validated; Region: pyrG; PRK05380 940190003131 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 940190003132 Catalytic site [active] 940190003133 active site 940190003134 UTP binding site [chemical binding]; other site 940190003135 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 940190003136 active site 940190003137 putative oxyanion hole; other site 940190003138 catalytic triad [active] 940190003139 Transglycosylase; Region: Transgly; pfam00912 940190003140 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 940190003141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 940190003142 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 940190003143 hypothetical protein; Provisional; Region: PRK13660 940190003144 cell division protein GpsB; Provisional; Region: PRK14127 940190003145 DivIVA domain; Region: DivI1A_domain; TIGR03544 940190003146 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 940190003147 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 940190003148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 940190003149 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 940190003150 Helix-turn-helix domain; Region: HTH_36; pfam13730 940190003151 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 940190003152 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 940190003153 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 940190003154 minor groove reading motif; other site 940190003155 helix-hairpin-helix signature motif; other site 940190003156 substrate binding pocket [chemical binding]; other site 940190003157 active site 940190003158 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 940190003159 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 940190003160 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 940190003161 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 940190003162 putative active site [active] 940190003163 catalytic site [active] 940190003164 putative metal binding site [ion binding]; other site 940190003165 manganese transport protein MntH; Reviewed; Region: PRK00701 940190003166 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 940190003167 LytTr DNA-binding domain; Region: LytTR; pfam04397 940190003168 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190003169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190003170 Walker A/P-loop; other site 940190003171 ATP binding site [chemical binding]; other site 940190003172 Q-loop/lid; other site 940190003173 ABC transporter signature motif; other site 940190003174 Walker B; other site 940190003175 D-loop; other site 940190003176 H-loop/switch region; other site 940190003177 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 940190003178 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 940190003179 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 940190003180 RimM N-terminal domain; Region: RimM; pfam01782 940190003181 PRC-barrel domain; Region: PRC; pfam05239 940190003182 putative DNA-binding protein; Validated; Region: PRK00118 940190003183 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 940190003184 GO:0003723; GO:0005525; GO:0006605; GO:0006614; GO:0016020; signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) 940190003185 Predicted flavoprotein [General function prediction only]; Region: COG0431 940190003186 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 940190003187 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 940190003188 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 940190003189 KH domain; Region: KH_4; pfam13083 940190003190 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 940190003191 conserved cis-peptide bond; other site 940190003192 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 940190003193 catalytic triad [active] 940190003194 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 940190003195 Domain of unknown function (DUF378); Region: DUF378; pfam04070 940190003196 Beta-lactamase; Region: Beta-lactamase; pfam00144 940190003197 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 940190003198 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 940190003199 active site 940190003200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 940190003201 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 940190003202 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 940190003203 tyrosine recombinase XerD 940190003204 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 940190003205 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 940190003206 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 940190003207 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190003208 RNA binding surface [nucleotide binding]; other site 940190003209 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 940190003210 active site 940190003211 Predicted membrane protein [Function unknown]; Region: COG3601 940190003212 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 940190003213 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 940190003214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190003215 cytidylate kinase; Provisional; Region: cmk; PRK00023 940190003216 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 940190003217 CMP-binding site; other site 940190003218 The sites determining sugar specificity; other site 940190003219 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 940190003220 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 940190003221 RNA binding site [nucleotide binding]; other site 940190003222 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 940190003223 RNA binding site [nucleotide binding]; other site 940190003224 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 940190003225 RNA binding site [nucleotide binding]; other site 940190003226 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 940190003227 RNA binding site [nucleotide binding]; other site 940190003228 GTP-binding protein Der; Reviewed; Region: PRK00093 940190003229 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 940190003230 G1 box; other site 940190003231 GTP/Mg2+ binding site [chemical binding]; other site 940190003232 Switch I region; other site 940190003233 G2 box; other site 940190003234 Switch II region; other site 940190003235 G3 box; other site 940190003236 G4 box; other site 940190003237 G5 box; other site 940190003238 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 940190003239 G1 box; other site 940190003240 GTP/Mg2+ binding site [chemical binding]; other site 940190003241 Switch I region; other site 940190003242 G2 box; other site 940190003243 G3 box; other site 940190003244 Switch II region; other site 940190003245 G4 box; other site 940190003246 G5 box; other site 940190003247 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 940190003248 IHF dimer interface [polypeptide binding]; other site 940190003249 IHF - DNA interface [nucleotide binding]; other site 940190003250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 940190003251 binding surface 940190003252 TPR motif; other site 940190003253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 940190003254 TPR motif; other site 940190003255 binding surface 940190003256 Uncharacterized conserved protein [Function unknown]; Region: COG1284 940190003257 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190003258 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 940190003259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 940190003260 homodimer interface [polypeptide binding]; other site 940190003261 metal binding site [ion binding]; metal-binding site 940190003262 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 940190003263 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 940190003264 active site 940190003265 NTP binding site [chemical binding]; other site 940190003266 metal binding triad [ion binding]; metal-binding site 940190003267 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 940190003268 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 940190003269 Predicted thioesterase [General function prediction only]; Region: COG5496 940190003270 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 940190003271 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 940190003272 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 940190003273 shikimate binding site; other site 940190003274 NAD(P) binding site [chemical binding]; other site 940190003275 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 940190003276 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 940190003277 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 940190003278 active site 940190003279 dimer interface [polypeptide binding]; other site 940190003280 metal binding site [ion binding]; metal-binding site 940190003281 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 940190003282 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 940190003283 Tetramer interface [polypeptide binding]; other site 940190003284 active site 940190003285 FMN-binding site [chemical binding]; other site 940190003286 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 940190003287 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 940190003288 hinge; other site 940190003289 active site 940190003290 shikimate kinase; Reviewed; Region: aroK; PRK00131 940190003291 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 940190003292 ADP binding site [chemical binding]; other site 940190003293 magnesium binding site [ion binding]; other site 940190003294 putative shikimate binding site; other site 940190003295 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 940190003296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190003297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190003298 Walker A/P-loop; other site 940190003299 ATP binding site [chemical binding]; other site 940190003300 Q-loop/lid; other site 940190003301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 940190003302 ABC transporter signature motif; other site 940190003303 Walker B; other site 940190003304 D-loop; other site 940190003305 ABC transporter; Region: ABC_tran_2; pfam12848 940190003306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190003307 Walker A/P-loop; other site 940190003308 ATP binding site [chemical binding]; other site 940190003309 Q-loop/lid; other site 940190003310 H-loop/switch region; other site 940190003311 thymidylate synthase; Region: thym_sym; TIGR03284 940190003312 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 940190003313 dimerization interface [polypeptide binding]; other site 940190003314 active site 940190003315 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 940190003316 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 940190003317 folate binding site [chemical binding]; other site 940190003318 NADP+ binding site [chemical binding]; other site 940190003319 LexA repressor; Validated; Region: PRK00215 940190003320 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 940190003321 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 940190003322 Catalytic site [active] 940190003323 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 940190003324 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 940190003325 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 940190003326 TPP-binding site [chemical binding]; other site 940190003327 dimer interface [polypeptide binding]; other site 940190003328 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 940190003329 PYR/PP interface [polypeptide binding]; other site 940190003330 dimer interface [polypeptide binding]; other site 940190003331 TPP binding site [chemical binding]; other site 940190003332 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 940190003333 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 940190003334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 940190003335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 940190003336 Predicted membrane protein [Function unknown]; Region: COG2364 940190003337 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190003338 Transcriptional regulator [Transcription]; Region: LytR; COG1316 940190003339 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 940190003340 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 940190003341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190003342 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 940190003343 Predicted membrane protein [Function unknown]; Region: COG1288 940190003344 carbamate kinase; Reviewed; Region: PRK12686 940190003345 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 940190003346 putative substrate binding site [chemical binding]; other site 940190003347 nucleotide binding site [chemical binding]; other site 940190003348 nucleotide binding site [chemical binding]; other site 940190003349 homodimer interface [polypeptide binding]; other site 940190003350 ornithine carbamoyltransferase; Validated; Region: PRK02102 940190003351 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 940190003352 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 940190003353 arginine deiminase; Provisional; Region: PRK01388 940190003354 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 940190003355 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 940190003356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 940190003357 active site turn [active] 940190003358 phosphorylation site [posttranslational modification] 940190003359 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 940190003360 HPr interaction site; other site 940190003361 glycerol kinase (GK) interaction site [polypeptide binding]; other site 940190003362 active site 940190003363 phosphorylation site [posttranslational modification] 940190003364 transcriptional antiterminator BglG; Provisional; Region: PRK09772 940190003365 CAT RNA binding domain; Region: CAT_RBD; smart01061 940190003366 PRD domain; Region: PRD; pfam00874 940190003367 PRD domain; Region: PRD; pfam00874 940190003368 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 940190003369 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190003370 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 940190003371 Walker A/P-loop; other site 940190003372 ATP binding site [chemical binding]; other site 940190003373 Q-loop/lid; other site 940190003374 ABC transporter signature motif; other site 940190003375 Walker B; other site 940190003376 D-loop; other site 940190003377 H-loop/switch region; other site 940190003378 potential frameshift: common BLAST hit: gi|194398015|ref|YP_002036820.1| ABC transporter membrane-spanning permease 940190003379 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 940190003380 Mga helix-turn-helix domain; Region: Mga; pfam05043 940190003381 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 940190003382 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 940190003383 DHH family; Region: DHH; pfam01368 940190003384 DHHA2 domain; Region: DHHA2; pfam02833 940190003385 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 940190003386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 940190003387 FeS/SAM binding site; other site 940190003388 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 940190003389 Pyruvate formate lyase 1; Region: PFL1; cd01678 940190003390 coenzyme A binding site [chemical binding]; other site 940190003391 active site 940190003392 catalytic residues [active] 940190003393 glycine loop; other site 940190003394 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 940190003395 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 940190003396 CAP-like domain; other site 940190003397 active site 940190003398 primary dimer interface [polypeptide binding]; other site 940190003399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 940190003400 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 940190003401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190003402 ATP binding site [chemical binding]; other site 940190003403 Mg2+ binding site [ion binding]; other site 940190003404 G-X-G motif; other site 940190003405 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 940190003406 anchoring element; other site 940190003407 dimer interface [polypeptide binding]; other site 940190003408 ATP binding site [chemical binding]; other site 940190003409 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 940190003410 active site 940190003411 putative metal-binding site [ion binding]; other site 940190003412 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 940190003413 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 940190003414 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 940190003415 active site 940190003416 catalytic residues [active] 940190003417 GTP-sensing transcriptional pleiotropic repressor CodY 940190003418 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 940190003419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 940190003420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190003421 Walker A motif; other site 940190003422 ATP binding site [chemical binding]; other site 940190003423 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 940190003424 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 940190003425 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 940190003426 active site 940190003427 HslU subunit interaction site [polypeptide binding]; other site 940190003428 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 940190003429 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 940190003430 active site 940190003431 DNA binding site [nucleotide binding] 940190003432 Int/Topo IB signature motif; other site 940190003433 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 940190003434 Glucose inhibited division protein A; Region: GIDA; pfam01134 940190003435 DNA topoisomerase I; Validated; Region: PRK05582 940190003436 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 940190003437 active site 940190003438 interdomain interaction site; other site 940190003439 putative metal-binding site [ion binding]; other site 940190003440 nucleotide binding site [chemical binding]; other site 940190003441 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 940190003442 domain I; other site 940190003443 DNA binding groove [nucleotide binding] 940190003444 phosphate binding site [ion binding]; other site 940190003445 domain II; other site 940190003446 domain III; other site 940190003447 nucleotide binding site [chemical binding]; other site 940190003448 catalytic site [active] 940190003449 domain IV; other site 940190003450 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 940190003451 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 940190003452 DNA protecting protein DprA; Region: dprA; TIGR00732 940190003453 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 940190003454 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 940190003455 RNA/DNA hybrid binding site [nucleotide binding]; other site 940190003456 active site 940190003457 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 940190003458 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 940190003459 GTP/Mg2+ binding site [chemical binding]; other site 940190003460 G4 box; other site 940190003461 G5 box; other site 940190003462 G1 box; other site 940190003463 Switch I region; other site 940190003464 G2 box; other site 940190003465 G3 box; other site 940190003466 Switch II region; other site 940190003467 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 940190003468 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 940190003469 active site 940190003470 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 940190003471 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 940190003472 Catalytic site [active] 940190003473 carboxyl-terminal protease 940190003474 hypothetical protein; Provisional; Region: PRK13672 940190003475 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 940190003476 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 940190003477 active site 940190003478 catalytic triad [active] 940190003479 oxyanion hole [active] 940190003480 EDD domain protein, DegV family; Region: DegV; TIGR00762 940190003481 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 940190003482 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 940190003483 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 940190003484 putative active site [active] 940190003485 metal binding site [ion binding]; metal-binding site 940190003486 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190003487 active site 940190003488 potential frameshift: common BLAST hit: gi|29376242|ref|NP_815396.1| single-stranded-DNA-specific exonuclease RecJ 940190003489 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 940190003490 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 940190003491 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 940190003492 DHH family; Region: DHH; pfam01368 940190003493 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 940190003494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 940190003495 NAD(P) binding site [chemical binding]; other site 940190003496 active site 940190003497 ribonuclease Z; Region: RNase_Z; TIGR02651 940190003498 GTPase CgtA; Reviewed; Region: obgE; PRK12297 940190003499 GTP1/OBG; Region: GTP1_OBG; pfam01018 940190003500 Obg GTPase; Region: Obg; cd01898 940190003501 G1 box; other site 940190003502 GTP/Mg2+ binding site [chemical binding]; other site 940190003503 Switch I region; other site 940190003504 G2 box; other site 940190003505 G3 box; other site 940190003506 Switch II region; other site 940190003507 G4 box; other site 940190003508 G5 box; other site 940190003509 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 940190003510 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 940190003511 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 940190003512 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 940190003513 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 940190003514 metal binding site 2 [ion binding]; metal-binding site 940190003515 putative DNA binding helix; other site 940190003516 metal binding site 1 [ion binding]; metal-binding site 940190003517 structural Zn2+ binding site [ion binding]; other site 940190003518 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 940190003519 S1 domain; Region: S1_2; pfam13509 940190003520 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 940190003521 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 940190003522 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 940190003523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 940190003524 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 940190003525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 940190003526 DNA binding residues [nucleotide binding] 940190003527 DNA primase, catalytic core; Region: dnaG; TIGR01391 940190003528 CHC2 zinc finger; Region: zf-CHC2; pfam01807 940190003529 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 940190003530 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 940190003531 active site 940190003532 metal binding site [ion binding]; metal-binding site 940190003533 interdomain interaction site; other site 940190003534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190003535 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 940190003536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190003537 motif II; other site 940190003538 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 940190003539 N-acetyl-D-glucosamine binding site [chemical binding]; other site 940190003540 catalytic residue [active] 940190003541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 940190003542 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 940190003543 Predicted integral membrane protein [Function unknown]; Region: COG0392 940190003544 Uncharacterized conserved protein [Function unknown]; Region: COG2898 940190003545 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 940190003546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190003547 active site 940190003548 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 940190003549 active site 940190003550 dimer interface [polypeptide binding]; other site 940190003551 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 940190003552 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 940190003553 heterodimer interface [polypeptide binding]; other site 940190003554 active site 940190003555 FMN binding site [chemical binding]; other site 940190003556 homodimer interface [polypeptide binding]; other site 940190003557 substrate binding site [chemical binding]; other site 940190003558 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 940190003559 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 940190003560 FAD binding pocket [chemical binding]; other site 940190003561 FAD binding motif [chemical binding]; other site 940190003562 phosphate binding motif [ion binding]; other site 940190003563 beta-alpha-beta structure motif; other site 940190003564 NAD binding pocket [chemical binding]; other site 940190003565 Iron coordination center [ion binding]; other site 940190003566 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 940190003567 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 940190003568 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 940190003569 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 940190003570 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 940190003571 ATP-grasp domain; Region: ATP-grasp_4; cl17255 940190003572 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 940190003573 IMP binding site; other site 940190003574 dimer interface [polypeptide binding]; other site 940190003575 interdomain contacts; other site 940190003576 partial ornithine binding site; other site 940190003577 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 940190003578 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 940190003579 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 940190003580 catalytic site [active] 940190003581 subunit interface [polypeptide binding]; other site 940190003582 dihydroorotase; Validated; Region: pyrC; PRK09357 940190003583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 940190003584 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 940190003585 active site 940190003586 potential frameshift: common BLAST hit: gi|29376271|ref|NP_815425.1| aspartate carbamoyltransferase catalytic subunit 940190003587 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 940190003588 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 940190003589 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 940190003590 uracil transporter; Provisional; Region: PRK10720 940190003591 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 940190003592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190003593 active site 940190003594 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 940190003595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 940190003596 RNA binding surface [nucleotide binding]; other site 940190003597 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 940190003598 active site 940190003599 lipoprotein signal peptidase; Provisional; Region: PRK14797 940190003600 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 940190003601 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 940190003602 Potassium binding sites [ion binding]; other site 940190003603 Cesium cation binding sites [ion binding]; other site 940190003604 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 940190003605 putative deacylase active site [active] 940190003606 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 940190003607 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 940190003608 putative RNA binding site [nucleotide binding]; other site 940190003609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190003610 S-adenosylmethionine binding site [chemical binding]; other site 940190003611 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 940190003612 Sulfatase; Region: Sulfatase; pfam00884 940190003613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 940190003614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 940190003615 dimerization interface [polypeptide binding]; other site 940190003616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190003617 dimer interface [polypeptide binding]; other site 940190003618 phosphorylation site [posttranslational modification] 940190003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190003620 ATP binding site [chemical binding]; other site 940190003621 G-X-G motif; other site 940190003622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190003623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190003624 active site 940190003625 phosphorylation site [posttranslational modification] 940190003626 intermolecular recognition site; other site 940190003627 dimerization interface [polypeptide binding]; other site 940190003628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190003629 DNA binding site [nucleotide binding] 940190003630 potential frameshift: common BLAST hit: gi|29375821|ref|NP_814975.1| fibronectin/fibrinogen-binding protein 940190003631 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 940190003632 Domain of unknown function (DUF814); Region: DUF814; pfam05670 940190003633 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 940190003634 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 940190003635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190003636 active site 940190003637 motif I; other site 940190003638 motif II; other site 940190003639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190003640 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 940190003641 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 940190003642 DNA binding site [nucleotide binding] 940190003643 active site 940190003644 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 940190003645 Domain of unknown function DUF20; Region: UPF0118; pfam01594 940190003646 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 940190003647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 940190003648 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 940190003649 S-ribosylhomocysteinase; Provisional; Region: PRK02260 940190003650 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 940190003651 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 940190003652 PYR/PP interface [polypeptide binding]; other site 940190003653 dimer interface [polypeptide binding]; other site 940190003654 tetramer interface [polypeptide binding]; other site 940190003655 TPP binding site [chemical binding]; other site 940190003656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 940190003657 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 940190003658 TPP-binding site [chemical binding]; other site 940190003659 Predicted esterase [General function prediction only]; Region: COG0400 940190003660 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 940190003661 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 940190003662 intersubunit interface [polypeptide binding]; other site 940190003663 active site 940190003664 Zn2+ binding site [ion binding]; other site 940190003665 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 940190003666 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 940190003667 putative N- and C-terminal domain interface [polypeptide binding]; other site 940190003668 putative active site [active] 940190003669 MgATP binding site [chemical binding]; other site 940190003670 catalytic site [active] 940190003671 metal binding site [ion binding]; metal-binding site 940190003672 putative carbohydrate binding site [chemical binding]; other site 940190003673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190003674 DNA-binding site [nucleotide binding]; DNA binding site 940190003675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190003676 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 940190003677 putative dimerization interface [polypeptide binding]; other site 940190003678 putative ligand binding site [chemical binding]; other site 940190003679 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190003680 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190003681 active site 940190003682 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 940190003683 active site 940190003684 catalytic residues [active] 940190003685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190003686 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 940190003687 transcription termination factor Rho; Provisional; Region: rho; PRK09376 940190003688 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 940190003689 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 940190003690 RNA binding site [nucleotide binding]; other site 940190003691 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 940190003692 multimer interface [polypeptide binding]; other site 940190003693 Walker A motif; other site 940190003694 ATP binding site [chemical binding]; other site 940190003695 Walker B motif; other site 940190003696 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 940190003697 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 940190003698 hinge; other site 940190003699 active site 940190003700 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 940190003701 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 940190003702 intersubunit interface [polypeptide binding]; other site 940190003703 active site 940190003704 zinc binding site [ion binding]; other site 940190003705 Na+ binding site [ion binding]; other site 940190003706 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 940190003707 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 940190003708 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 940190003709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 940190003710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190003711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 940190003712 lipoxygenase; Region: PLN02264 940190003713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 940190003714 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 940190003715 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 940190003716 active site 940190003717 catalytic site [active] 940190003718 substrate binding site [chemical binding]; other site 940190003719 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 940190003720 Amino acid permease; Region: AA_permease_2; pfam13520 940190003721 DNA polymerase III PolC; Validated; Region: polC; PRK00448 940190003722 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 940190003723 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 940190003724 generic binding surface I; other site 940190003725 generic binding surface II; other site 940190003726 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 940190003727 active site 940190003728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 940190003729 active site 940190003730 catalytic site [active] 940190003731 substrate binding site [chemical binding]; other site 940190003732 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 940190003733 prolyl-tRNA synthetase; Provisional; Region: PRK09194 940190003734 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 940190003735 dimer interface [polypeptide binding]; other site 940190003736 motif 1; other site 940190003737 active site 940190003738 motif 2; other site 940190003739 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 940190003740 putative deacylase active site [active] 940190003741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 940190003742 active site 940190003743 motif 3; other site 940190003744 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 940190003745 anticodon binding site; other site 940190003746 RIP metalloprotease RseP; Region: TIGR00054 940190003747 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 940190003748 active site 940190003749 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 940190003750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 940190003751 protein binding site [polypeptide binding]; other site 940190003752 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 940190003753 putative substrate binding region [chemical binding]; other site 940190003754 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 940190003755 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 940190003756 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 940190003757 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 940190003758 catalytic residue [active] 940190003759 putative FPP diphosphate binding site; other site 940190003760 putative FPP binding hydrophobic cleft; other site 940190003761 dimer interface [polypeptide binding]; other site 940190003762 putative IPP diphosphate binding site; other site 940190003763 ribosome recycling factor; Reviewed; Region: frr; PRK00083 940190003764 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 940190003765 hinge region; other site 940190003766 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 940190003767 putative nucleotide binding site [chemical binding]; other site 940190003768 uridine monophosphate binding site [chemical binding]; other site 940190003769 homohexameric interface [polypeptide binding]; other site 940190003770 elongation factor Ts; Provisional; Region: tsf; PRK09377 940190003771 UBA/TS-N domain; Region: UBA; pfam00627 940190003772 Elongation factor TS; Region: EF_TS; pfam00889 940190003773 Elongation factor TS; Region: EF_TS; pfam00889 940190003774 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 940190003775 rRNA interaction site [nucleotide binding]; other site 940190003776 S8 interaction site; other site 940190003777 putative laminin-1 binding site; other site 940190003778 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 940190003779 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 940190003780 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 940190003781 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 940190003782 OxaA-like protein precursor; Provisional; Region: PRK02463 940190003783 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 940190003784 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 940190003785 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 940190003786 dimer interface [polypeptide binding]; other site 940190003787 motif 1; other site 940190003788 active site 940190003789 motif 2; other site 940190003790 motif 3; other site 940190003791 Recombination protein O N terminal; Region: RecO_N; pfam11967 940190003792 DNA repair protein RecO; Region: reco; TIGR00613 940190003793 Recombination protein O C terminal; Region: RecO_C; pfam02565 940190003794 GTPase Era; Reviewed; Region: era; PRK00089 940190003795 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 940190003796 G1 box; other site 940190003797 GTP/Mg2+ binding site [chemical binding]; other site 940190003798 Switch I region; other site 940190003799 G2 box; other site 940190003800 Switch II region; other site 940190003801 G3 box; other site 940190003802 G4 box; other site 940190003803 G5 box; other site 940190003804 KH domain; Region: KH_2; pfam07650 940190003805 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 940190003806 metal-binding heat shock protein; Provisional; Region: PRK00016 940190003807 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 940190003808 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 940190003809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190003810 Zn2+ binding site [ion binding]; other site 940190003811 Mg2+ binding site [ion binding]; other site 940190003812 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 940190003813 PhoH-like protein; Region: PhoH; pfam02562 940190003814 Yqey-like protein; Region: YqeY; pfam09424 940190003815 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 940190003816 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 940190003817 metal binding site 2 [ion binding]; metal-binding site 940190003818 putative DNA binding helix; other site 940190003819 metal binding site 1 [ion binding]; metal-binding site 940190003820 dimer interface [polypeptide binding]; other site 940190003821 structural Zn2+ binding site [ion binding]; other site 940190003822 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 940190003823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 940190003824 dimerization interface [polypeptide binding]; other site 940190003825 putative DNA binding site [nucleotide binding]; other site 940190003826 putative Zn2+ binding site [ion binding]; other site 940190003827 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 940190003828 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 940190003829 active site 940190003830 substrate binding site [chemical binding]; other site 940190003831 metal binding site [ion binding]; metal-binding site 940190003832 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 940190003833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190003834 DNA-binding site [nucleotide binding]; DNA binding site 940190003835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190003836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190003837 homodimer interface [polypeptide binding]; other site 940190003838 catalytic residue [active] 940190003839 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 940190003840 dimer interface [polypeptide binding]; other site 940190003841 substrate binding site [chemical binding]; other site 940190003842 ATP binding site [chemical binding]; other site 940190003843 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 940190003844 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 940190003845 active site 940190003846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190003847 catalytic core [active] 940190003848 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 940190003849 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190003850 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 940190003851 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190003852 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190003853 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 940190003854 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 940190003855 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 940190003856 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 940190003857 Competence protein; Region: Competence; pfam03772 940190003858 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 940190003859 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 940190003860 SLBB domain; Region: SLBB; pfam10531 940190003861 comEA protein; Region: comE; TIGR01259 940190003862 Lon-like protease with PDZ domain 940190003863 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 940190003864 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 940190003865 active site 940190003866 (T/H)XGH motif; other site 940190003867 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 940190003868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190003869 S-adenosylmethionine binding site [chemical binding]; other site 940190003870 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 940190003871 Protein of unknown function (DUF964); Region: DUF964; pfam06133 940190003872 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 940190003873 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 940190003874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190003875 ATP binding site [chemical binding]; other site 940190003876 putative Mg++ binding site [ion binding]; other site 940190003877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190003878 nucleotide binding region [chemical binding]; other site 940190003879 ATP-binding site [chemical binding]; other site 940190003880 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 940190003881 HRDC domain; Region: HRDC; pfam00570 940190003882 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 940190003883 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 940190003884 G1 box; other site 940190003885 putative GEF interaction site [polypeptide binding]; other site 940190003886 GTP/Mg2+ binding site [chemical binding]; other site 940190003887 Switch I region; other site 940190003888 G2 box; other site 940190003889 G3 box; other site 940190003890 Switch II region; other site 940190003891 G4 box; other site 940190003892 G5 box; other site 940190003893 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 940190003894 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 940190003895 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 940190003896 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 940190003897 active site 940190003898 hypothetical protein; Provisional; Region: PRK04387 940190003899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190003900 Zn2+ binding site [ion binding]; other site 940190003901 Mg2+ binding site [ion binding]; other site 940190003902 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 940190003903 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 940190003904 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 940190003905 active site 940190003906 HIGH motif; other site 940190003907 KMSK motif region; other site 940190003908 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 940190003909 tRNA binding surface [nucleotide binding]; other site 940190003910 anticodon binding site; other site 940190003911 UGMP family protein; Validated; Region: PRK09604 940190003912 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 940190003913 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 940190003914 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 940190003915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190003916 Coenzyme A binding pocket [chemical binding]; other site 940190003917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 940190003918 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 940190003919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190003920 Coenzyme A binding pocket [chemical binding]; other site 940190003921 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 940190003922 Glycoprotease family; Region: Peptidase_M22; pfam00814 940190003923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190003924 hypothetical protein; Provisional; Region: PRK04351 940190003925 SprT homologues; Region: SprT; cl01182 940190003926 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 940190003927 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 940190003928 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 940190003929 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 940190003930 RNA binding site [nucleotide binding]; other site 940190003931 chaperone protein DnaJ; Provisional; Region: PRK14276 940190003932 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 940190003933 HSP70 interaction site [polypeptide binding]; other site 940190003934 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 940190003935 substrate binding site [polypeptide binding]; other site 940190003936 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 940190003937 Zn binding sites [ion binding]; other site 940190003938 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 940190003939 substrate binding site [polypeptide binding]; other site 940190003940 dimer interface [polypeptide binding]; other site 940190003941 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 940190003942 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 940190003943 nucleotide binding site [chemical binding]; other site 940190003944 NEF interaction site [polypeptide binding]; other site 940190003945 SBD interface [polypeptide binding]; other site 940190003946 GrpE; Region: GrpE; pfam01025 940190003947 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 940190003948 dimer interface [polypeptide binding]; other site 940190003949 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 940190003950 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 940190003951 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 940190003952 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 940190003953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 940190003954 FeS/SAM binding site; other site 940190003955 HemN C-terminal domain; Region: HemN_C; pfam06969 940190003956 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 940190003957 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 940190003958 active site 940190003959 Riboflavin kinase; Region: Flavokinase; smart00904 940190003960 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 940190003961 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 940190003962 RNA binding site [nucleotide binding]; other site 940190003963 active site 940190003964 Tic20-like protein; Region: Tic20; pfam09685 940190003965 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 940190003966 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 940190003967 translation initiation factor IF-2; Region: IF-2; TIGR00487 940190003968 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 940190003969 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 940190003970 G1 box; other site 940190003971 putative GEF interaction site [polypeptide binding]; other site 940190003972 GTP/Mg2+ binding site [chemical binding]; other site 940190003973 Switch I region; other site 940190003974 G2 box; other site 940190003975 G3 box; other site 940190003976 Switch II region; other site 940190003977 G4 box; other site 940190003978 G5 box; other site 940190003979 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 940190003980 Translation-initiation factor 2; Region: IF-2; pfam11987 940190003981 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 940190003982 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 940190003983 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 940190003984 putative RNA binding cleft [nucleotide binding]; other site 940190003985 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 940190003986 NusA N-terminal domain; Region: NusA_N; pfam08529 940190003987 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 940190003988 RNA binding site [nucleotide binding]; other site 940190003989 homodimer interface [polypeptide binding]; other site 940190003990 NusA-like KH domain; Region: KH_5; pfam13184 940190003991 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 940190003992 G-X-X-G motif; other site 940190003993 ribosome maturation protein RimP; Reviewed; Region: PRK00092 940190003994 Sm and related proteins; Region: Sm_like; cl00259 940190003995 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 940190003996 putative oligomer interface [polypeptide binding]; other site 940190003997 putative RNA binding site [nucleotide binding]; other site 940190003998 ribonuclease HIII; Provisional; Region: PRK00996 940190003999 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 940190004000 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 940190004001 RNA/DNA hybrid binding site [nucleotide binding]; other site 940190004002 active site 940190004003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004004 non-specific DNA binding site [nucleotide binding]; other site 940190004005 salt bridge; other site 940190004006 sequence-specific DNA binding site [nucleotide binding]; other site 940190004007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 940190004008 binding surface 940190004009 TPR motif; other site 940190004010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 940190004011 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 940190004012 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 940190004013 methionine cluster; other site 940190004014 active site 940190004015 phosphorylation site [posttranslational modification] 940190004016 metal binding site [ion binding]; metal-binding site 940190004017 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 940190004018 Uncharacterized conserved protein [Function unknown]; Region: COG3589 940190004019 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 940190004020 potential frameshift: common BLAST hit: gi|308182047|ref|YP_003926175.1| cellobiose PTS, EIIC 940190004021 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 940190004022 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 940190004023 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 940190004024 active site 940190004025 P-loop; other site 940190004026 phosphorylation site [posttranslational modification] 940190004027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 940190004028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 940190004029 DNA binding site [nucleotide binding] 940190004030 domain linker motif; other site 940190004031 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 940190004032 ligand binding site [chemical binding]; other site 940190004033 dimerization interface [polypeptide binding]; other site 940190004034 hypothetical protein; Provisional; Region: PRK13678 940190004035 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 940190004036 hypothetical protein; Provisional; Region: PRK05473 940190004037 Uncharacterized conserved protein [Function unknown]; Region: COG2966 940190004038 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 940190004039 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 940190004040 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 940190004041 Domain of unknown function (DUF1980); Region: DUF1980; pfam09323 940190004042 possible permease 940190004043 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 940190004044 YycH protein; Region: YycI; pfam09648 940190004045 YycH protein; Region: YycH; pfam07435 940190004046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 940190004047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 940190004048 dimerization interface [polypeptide binding]; other site 940190004049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 940190004050 putative active site [active] 940190004051 heme pocket [chemical binding]; other site 940190004052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190004053 dimer interface [polypeptide binding]; other site 940190004054 phosphorylation site [posttranslational modification] 940190004055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190004056 ATP binding site [chemical binding]; other site 940190004057 Mg2+ binding site [ion binding]; other site 940190004058 G-X-G motif; other site 940190004059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190004060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190004061 active site 940190004062 phosphorylation site [posttranslational modification] 940190004063 intermolecular recognition site; other site 940190004064 dimerization interface [polypeptide binding]; other site 940190004065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190004066 DNA binding site [nucleotide binding] 940190004067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 940190004068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004069 non-specific DNA binding site [nucleotide binding]; other site 940190004070 salt bridge; other site 940190004071 sequence-specific DNA binding site [nucleotide binding]; other site 940190004072 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 940190004073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004074 H-loop/switch region; other site 940190004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004076 Walker A/P-loop; other site 940190004077 ATP binding site [chemical binding]; other site 940190004078 Q-loop/lid; other site 940190004079 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 940190004080 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 940190004081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 940190004082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 940190004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190004084 dimer interface [polypeptide binding]; other site 940190004085 phosphorylation site [posttranslational modification] 940190004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190004087 ATP binding site [chemical binding]; other site 940190004088 Mg2+ binding site [ion binding]; other site 940190004089 G-X-G motif; other site 940190004090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190004091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190004092 active site 940190004093 phosphorylation site [posttranslational modification] 940190004094 intermolecular recognition site; other site 940190004095 dimerization interface [polypeptide binding]; other site 940190004096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190004097 DNA binding site [nucleotide binding] 940190004098 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 940190004099 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 940190004100 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 940190004101 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 940190004102 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 940190004103 pyruvate kinase; Provisional; Region: PRK06354 940190004104 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 940190004105 domain interfaces; other site 940190004106 active site 940190004107 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 940190004108 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 940190004109 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 940190004110 active site 940190004111 ADP/pyrophosphate binding site [chemical binding]; other site 940190004112 dimerization interface [polypeptide binding]; other site 940190004113 allosteric effector site; other site 940190004114 fructose-1,6-bisphosphate binding site; other site 940190004115 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 940190004116 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 940190004117 active site 940190004118 PHP Thumb interface [polypeptide binding]; other site 940190004119 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 940190004120 generic binding surface I; other site 940190004121 generic binding surface II; other site 940190004122 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 940190004123 drug efflux system protein MdtG; Provisional; Region: PRK09874 940190004124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190004125 putative substrate translocation pore; other site 940190004126 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 940190004127 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 940190004128 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 940190004129 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 940190004130 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 940190004131 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 940190004132 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 940190004133 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 940190004134 purine monophosphate binding site [chemical binding]; other site 940190004135 dimer interface [polypeptide binding]; other site 940190004136 putative catalytic residues [active] 940190004137 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 940190004138 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 940190004139 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 940190004140 active site 940190004141 substrate binding site [chemical binding]; other site 940190004142 cosubstrate binding site; other site 940190004143 catalytic site [active] 940190004144 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 940190004145 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 940190004146 dimerization interface [polypeptide binding]; other site 940190004147 putative ATP binding site [chemical binding]; other site 940190004148 amidophosphoribosyltransferase; Provisional; Region: PRK07272 940190004149 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 940190004150 active site 940190004151 tetramer interface [polypeptide binding]; other site 940190004152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190004153 active site 940190004154 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 940190004155 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 940190004156 dimerization interface [polypeptide binding]; other site 940190004157 ATP binding site [chemical binding]; other site 940190004158 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 940190004159 dimerization interface [polypeptide binding]; other site 940190004160 ATP binding site [chemical binding]; other site 940190004161 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 940190004162 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 940190004163 putative active site [active] 940190004164 catalytic triad [active] 940190004165 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 940190004166 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 940190004167 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 940190004168 active site 940190004169 substrate binding site [chemical binding]; other site 940190004170 adenylosuccinate lyase; Provisional; Region: PRK07492 940190004171 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 940190004172 tetramer interface [polypeptide binding]; other site 940190004173 active site 940190004174 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 940190004175 ATP-grasp domain; Region: ATP-grasp; pfam02222 940190004176 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 940190004177 xanthine permease; Region: pbuX; TIGR03173 940190004178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190004179 active site 940190004180 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 940190004181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 940190004182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 940190004183 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 940190004184 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 940190004185 glycogen synthase; Provisional; Region: glgA; PRK00654 940190004186 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 940190004187 ADP-binding pocket [chemical binding]; other site 940190004188 homodimer interface [polypeptide binding]; other site 940190004189 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 940190004190 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 940190004191 oligomer interface; other site 940190004192 ligand binding site; other site 940190004193 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 940190004194 dimer interface [polypeptide binding]; other site 940190004195 N-terminal domain interface [polypeptide binding]; other site 940190004196 sulfate 1 binding site; other site 940190004197 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 940190004198 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 940190004199 ligand binding site; other site 940190004200 oligomer interface; other site 940190004201 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 940190004202 dimer interface [polypeptide binding]; other site 940190004203 N-terminal domain interface [polypeptide binding]; other site 940190004204 sulfate 1 binding site; other site 940190004205 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 940190004206 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 940190004207 dimer interface [polypeptide binding]; other site 940190004208 anticodon binding site; other site 940190004209 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 940190004210 homodimer interface [polypeptide binding]; other site 940190004211 motif 1; other site 940190004212 active site 940190004213 motif 2; other site 940190004214 GAD domain; Region: GAD; pfam02938 940190004215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 940190004216 active site 940190004217 motif 3; other site 940190004218 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 940190004219 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 940190004220 dimer interface [polypeptide binding]; other site 940190004221 motif 1; other site 940190004222 active site 940190004223 motif 2; other site 940190004224 motif 3; other site 940190004225 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 940190004226 anticodon binding site; other site 940190004227 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 940190004228 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 940190004229 FtsX-like permease family; Region: FtsX; pfam02687 940190004230 ABC transporter, ATP-binding protein 940190004231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 940190004232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 940190004233 active site 940190004234 catalytic tetrad [active] 940190004235 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 940190004236 putative active site [active] 940190004237 dimerization interface [polypeptide binding]; other site 940190004238 putative tRNAtyr binding site [nucleotide binding]; other site 940190004239 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 940190004240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190004241 Zn2+ binding site [ion binding]; other site 940190004242 Mg2+ binding site [ion binding]; other site 940190004243 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 940190004244 synthetase active site [active] 940190004245 NTP binding site [chemical binding]; other site 940190004246 metal binding site [ion binding]; metal-binding site 940190004247 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 940190004248 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 940190004249 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 940190004250 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 940190004251 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 940190004252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190004253 S-adenosylmethionine binding site [chemical binding]; other site 940190004254 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 940190004255 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 940190004256 active site 940190004257 DNA binding site [nucleotide binding] 940190004258 recombination factor protein RarA; Reviewed; Region: PRK13342 940190004259 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 940190004260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190004261 Walker A motif; other site 940190004262 ATP binding site [chemical binding]; other site 940190004263 Walker B motif; other site 940190004264 arginine finger; other site 940190004265 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 940190004266 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 940190004267 Ligand Binding Site [chemical binding]; other site 940190004268 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 940190004269 propionate/acetate kinase; Provisional; Region: PRK12379 940190004270 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 940190004271 Methyltransferase domain; Region: Methyltransf_26; pfam13659 940190004272 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 940190004273 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 940190004274 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 940190004275 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 940190004276 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 940190004277 Haemolysin XhlA; Region: XhlA; pfam10779 940190004278 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 940190004279 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 940190004280 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 940190004281 Phage tail protein; Region: Sipho_tail; pfam05709 940190004282 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 940190004283 N-acetyl-D-glucosamine binding site [chemical binding]; other site 940190004284 catalytic residue [active] 940190004285 tape measure domain; Region: tape_meas_nterm; TIGR02675 940190004286 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 940190004287 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 940190004288 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 940190004289 Minor capsid protein; Region: Minor_capsid_2; pfam11114 940190004290 Minor capsid protein; Region: Minor_capsid_1; pfam10665 940190004291 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 940190004292 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 940190004293 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 940190004294 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 940190004295 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 940190004296 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 940190004297 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 940190004298 potential frameshift: common BLAST hit: gi|16804339|ref|NP_465824.1| terminase large subunit from bacteriophage A118 940190004299 Phage terminase large subunit; Region: Terminase_3; cl12054 940190004300 potential frameshift: common BLAST hit: gi|258508120|ref|YP_003170871.1| phage-related terminase large subunit 940190004301 Phage terminase large subunit; Region: Terminase_3; cl12054 940190004302 Phage terminase large subunit; Region: Terminase_3; cl12054 940190004303 Terminase small subunit; Region: Terminase_2; pfam03592 940190004304 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 940190004305 Endodeoxyribonuclease RusA; Region: RusA; cl01885 940190004306 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 940190004307 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 940190004308 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 940190004309 dimer interface [polypeptide binding]; other site 940190004310 ssDNA binding site [nucleotide binding]; other site 940190004311 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 940190004312 Protein of unknown function (DUF968); Region: DUF968; pfam06147 940190004313 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 940190004314 RecT family; Region: RecT; cl04285 940190004315 Prophage antirepressor [Transcription]; Region: COG3617 940190004316 BRO family, N-terminal domain; Region: Bro-N; smart01040 940190004317 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 940190004318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004319 non-specific DNA binding site [nucleotide binding]; other site 940190004320 salt bridge; other site 940190004321 sequence-specific DNA binding site [nucleotide binding]; other site 940190004322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 940190004323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004324 non-specific DNA binding site [nucleotide binding]; other site 940190004325 salt bridge; other site 940190004326 sequence-specific DNA binding site [nucleotide binding]; other site 940190004327 Predicted transcriptional regulator [Transcription]; Region: COG2932 940190004328 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 940190004329 Catalytic site [active] 940190004330 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 940190004331 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 940190004332 catalytic residues [active] 940190004333 catalytic nucleophile [active] 940190004334 Presynaptic Site I dimer interface [polypeptide binding]; other site 940190004335 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 940190004336 Synaptic Flat tetramer interface [polypeptide binding]; other site 940190004337 Synaptic Site I dimer interface [polypeptide binding]; other site 940190004338 DNA binding site [nucleotide binding] 940190004339 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 940190004340 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 940190004341 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 940190004342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 940190004343 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 940190004344 Walker A motif; other site 940190004345 ATP binding site [chemical binding]; other site 940190004346 Walker B motif; other site 940190004347 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 940190004348 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 940190004349 metal binding site [ion binding]; metal-binding site 940190004350 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 940190004351 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190004352 ABC-ATPase subunit interface; other site 940190004353 dimer interface [polypeptide binding]; other site 940190004354 putative PBP binding regions; other site 940190004355 potential frameshift: common BLAST hit: gi|125623967|ref|YP_001032450.1| manganese ABC transporter ATP binding protein 940190004356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004357 H-loop/switch region; other site 940190004358 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 940190004359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004360 Q-loop/lid; other site 940190004361 ABC transporter signature motif; other site 940190004362 Walker B; other site 940190004363 D-loop; other site 940190004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004365 Transcriptional regulator [Transcription]; Region: LytR; COG1316 940190004366 GTP-binding protein LepA; Provisional; Region: PRK05433 940190004367 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 940190004368 G1 box; other site 940190004369 putative GEF interaction site [polypeptide binding]; other site 940190004370 GTP/Mg2+ binding site [chemical binding]; other site 940190004371 Switch I region; other site 940190004372 G2 box; other site 940190004373 G3 box; other site 940190004374 Switch II region; other site 940190004375 G4 box; other site 940190004376 G5 box; other site 940190004377 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 940190004378 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 940190004379 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 940190004380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 940190004381 Sterol carrier protein domain; Region: SCP2_2; pfam13530 940190004382 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 940190004383 mannonate dehydratase; Provisional; Region: PRK03906 940190004384 mannonate dehydratase; Region: uxuA; TIGR00695 940190004385 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 940190004386 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 940190004387 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 940190004388 Uncharacterized conserved protein [Function unknown]; Region: COG1284 940190004389 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190004390 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 940190004391 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 940190004392 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 940190004393 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 940190004394 potential frameshift: common BLAST hit: gi|29377280|ref|NP_816434.1| minor structural protein 940190004395 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 940190004396 Phage-related protein [Function unknown]; Region: PblB; COG4926 940190004397 Phage tail protein; Region: Sipho_tail; cl17486 940190004398 Phage-related protein [Function unknown]; Region: COG4722 940190004399 Phage-related protein [Function unknown]; Region: COG5412 940190004400 Phage protein; Region: DUF3647; pfam12363 940190004401 Phage major tail protein 2; Region: Phage_tail_2; cl11463 940190004402 Right handed beta helix region; Region: Beta_helix; pfam13229 940190004403 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 940190004404 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 940190004405 BetR domain; Region: BetR; pfam08667 940190004406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004407 non-specific DNA binding site [nucleotide binding]; other site 940190004408 salt bridge; other site 940190004409 sequence-specific DNA binding site [nucleotide binding]; other site 940190004410 Predicted transcriptional regulator [Transcription]; Region: COG2932 940190004411 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 940190004412 Catalytic site [active] 940190004413 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 940190004414 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 940190004415 homotrimer interaction site [polypeptide binding]; other site 940190004416 putative active site [active] 940190004417 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 940190004418 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 940190004419 Walker A/P-loop; other site 940190004420 ATP binding site [chemical binding]; other site 940190004421 Q-loop/lid; other site 940190004422 ABC transporter signature motif; other site 940190004423 Walker B; other site 940190004424 D-loop; other site 940190004425 H-loop/switch region; other site 940190004426 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 940190004427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 940190004428 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 940190004429 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190004430 ABC-ATPase subunit interface; other site 940190004431 dimer interface [polypeptide binding]; other site 940190004432 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 940190004433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 940190004434 dimer interface [polypeptide binding]; other site 940190004435 ABC-ATPase subunit interface; other site 940190004436 putative PBP binding regions; other site 940190004437 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 940190004438 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 940190004439 siderophore binding site; other site 940190004440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 940190004441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 940190004442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190004443 dimer interface [polypeptide binding]; other site 940190004444 phosphorylation site [posttranslational modification] 940190004445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190004446 ATP binding site [chemical binding]; other site 940190004447 Mg2+ binding site [ion binding]; other site 940190004448 G-X-G motif; other site 940190004449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190004450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190004451 DNA binding site [nucleotide binding] 940190004452 Response regulator receiver domain; Region: Response_reg; pfam00072 940190004453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190004454 active site 940190004455 phosphorylation site [posttranslational modification] 940190004456 intermolecular recognition site; other site 940190004457 dimerization interface [polypeptide binding]; other site 940190004458 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 940190004459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004460 Walker A/P-loop; other site 940190004461 ATP binding site [chemical binding]; other site 940190004462 Q-loop/lid; other site 940190004463 ABC transporter signature motif; other site 940190004464 Walker B; other site 940190004465 D-loop; other site 940190004466 H-loop/switch region; other site 940190004467 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 940190004468 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 940190004469 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 940190004470 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 940190004471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190004472 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 940190004473 active site 940190004474 motif I; other site 940190004475 motif II; other site 940190004476 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 940190004477 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 940190004478 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 940190004479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 940190004480 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 940190004481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190004482 motif II; other site 940190004483 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 940190004484 nudix motif; other site 940190004485 potential frameshift: common BLAST hit: gi|23217024|ref|NP_690631.2| type I R/M system specificity subunit 940190004486 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 940190004487 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 940190004488 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 940190004489 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 940190004490 potential frameshift: common BLAST hit: gi|284993983|ref|YP_003415751.1| type I restriction enzyme M protein 940190004491 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 940190004492 potential frameshift: common BLAST hit: gi|226223147|ref|YP_002757254.1| HsdM type IC modification subunit 940190004493 Methyltransferase domain; Region: Methyltransf_26; pfam13659 940190004494 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 940190004495 HsdM N-terminal domain; Region: HsdM_N; pfam12161 940190004496 potential frameshift: common BLAST hit: gi|284800796|ref|YP_003412661.1| type I restriction enzyme, R subunit 940190004497 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 940190004498 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 940190004499 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 940190004500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 940190004501 ATP binding site [chemical binding]; other site 940190004502 putative Mg++ binding site [ion binding]; other site 940190004503 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 940190004504 nudix motif; other site 940190004505 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 940190004506 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 940190004507 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 940190004508 FeS assembly protein SufB; Region: sufB; TIGR01980 940190004509 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 940190004510 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 940190004511 trimerization site [polypeptide binding]; other site 940190004512 active site 940190004513 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 940190004514 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 940190004515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 940190004516 catalytic residue [active] 940190004517 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 940190004518 FeS assembly protein SufD; Region: sufD; TIGR01981 940190004519 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 940190004520 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 940190004521 Walker A/P-loop; other site 940190004522 ATP binding site [chemical binding]; other site 940190004523 Q-loop/lid; other site 940190004524 ABC transporter signature motif; other site 940190004525 Walker B; other site 940190004526 D-loop; other site 940190004527 H-loop/switch region; other site 940190004528 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 940190004529 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 940190004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004531 dimer interface [polypeptide binding]; other site 940190004532 conserved gate region; other site 940190004533 ABC-ATPase subunit interface; other site 940190004534 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 940190004535 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 940190004536 Walker A/P-loop; other site 940190004537 ATP binding site [chemical binding]; other site 940190004538 Q-loop/lid; other site 940190004539 ABC transporter signature motif; other site 940190004540 Walker B; other site 940190004541 D-loop; other site 940190004542 H-loop/switch region; other site 940190004543 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 940190004544 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 940190004545 ArsC family; Region: ArsC; pfam03960 940190004546 putative ArsC-like catalytic residues; other site 940190004547 putative TRX-like catalytic residues [active] 940190004548 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 940190004549 lipoyl attachment site [posttranslational modification]; other site 940190004550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 940190004551 active site 940190004552 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 940190004553 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 940190004554 dimer interface [polypeptide binding]; other site 940190004555 active site 940190004556 glycine-pyridoxal phosphate binding site [chemical binding]; other site 940190004557 folate binding site [chemical binding]; other site 940190004558 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 940190004559 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 940190004560 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 940190004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190004562 S-adenosylmethionine binding site [chemical binding]; other site 940190004563 peptide chain release factor 1; Validated; Region: prfA; PRK00591 940190004564 This domain is found in peptide chain release factors; Region: PCRF; smart00937 940190004565 RF-1 domain; Region: RF-1; pfam00472 940190004566 thymidine kinase; Provisional; Region: PRK04296 940190004567 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 940190004568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190004569 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 940190004570 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 940190004571 catalytic triad [active] 940190004572 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 940190004573 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 940190004574 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 940190004575 Beta-lactamase; Region: Beta-lactamase; pfam00144 940190004576 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 940190004577 active site 940190004578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 940190004579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190004580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190004581 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 940190004582 Walker A/P-loop; other site 940190004583 ATP binding site [chemical binding]; other site 940190004584 Q-loop/lid; other site 940190004585 ABC transporter signature motif; other site 940190004586 Walker B; other site 940190004587 D-loop; other site 940190004588 H-loop/switch region; other site 940190004589 potential frameshift: common BLAST hit: gi|29377080|ref|NP_816234.1| ABC transporter, ATP-binding/permease 940190004590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004591 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190004592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190004593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004594 Walker A/P-loop; other site 940190004595 ATP binding site [chemical binding]; other site 940190004596 Q-loop/lid; other site 940190004597 ABC transporter signature motif; other site 940190004598 Walker B; other site 940190004599 D-loop; other site 940190004600 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 940190004601 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 940190004602 active site 940190004603 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 940190004604 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 940190004605 HPr interaction site; other site 940190004606 glycerol kinase (GK) interaction site [polypeptide binding]; other site 940190004607 active site 940190004608 phosphorylation site [posttranslational modification] 940190004609 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 940190004610 active site turn [active] 940190004611 phosphorylation site [posttranslational modification] 940190004612 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 940190004613 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 940190004614 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 940190004615 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 940190004616 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 940190004617 hinge; other site 940190004618 active site 940190004619 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 940190004620 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 940190004621 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 940190004622 gamma subunit interface [polypeptide binding]; other site 940190004623 epsilon subunit interface [polypeptide binding]; other site 940190004624 LBP interface [polypeptide binding]; other site 940190004625 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 940190004626 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 940190004627 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 940190004628 alpha subunit interaction interface [polypeptide binding]; other site 940190004629 Walker A motif; other site 940190004630 ATP binding site [chemical binding]; other site 940190004631 Walker B motif; other site 940190004632 inhibitor binding site; inhibition site 940190004633 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 940190004634 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 940190004635 core domain interface [polypeptide binding]; other site 940190004636 delta subunit interface [polypeptide binding]; other site 940190004637 epsilon subunit interface [polypeptide binding]; other site 940190004638 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 940190004639 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 940190004640 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 940190004641 beta subunit interaction interface [polypeptide binding]; other site 940190004642 Walker A motif; other site 940190004643 ATP binding site [chemical binding]; other site 940190004644 Walker B motif; other site 940190004645 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 940190004646 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 940190004647 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 940190004648 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 940190004649 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 940190004650 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 940190004651 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 940190004652 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 940190004653 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 940190004654 SmpB-tmRNA interface; other site 940190004655 ribonuclease R; Region: RNase_R; TIGR02063 940190004656 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 940190004657 RNB domain; Region: RNB; pfam00773 940190004658 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 940190004659 RNA binding site [nucleotide binding]; other site 940190004660 Esterase/lipase [General function prediction only]; Region: COG1647 940190004661 Preprotein translocase SecG subunit; Region: SecG; pfam03840 940190004662 Predicted acetyltransferase [General function prediction only]; Region: COG2388 940190004663 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 940190004664 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 940190004665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190004666 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190004667 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 940190004668 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 940190004669 homodimer interface [polypeptide binding]; other site 940190004670 NAD binding pocket [chemical binding]; other site 940190004671 ATP binding pocket [chemical binding]; other site 940190004672 Mg binding site [ion binding]; other site 940190004673 active-site loop [active] 940190004674 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 940190004675 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 940190004676 active site 940190004677 Predicted membrane protein [Function unknown]; Region: COG2246 940190004678 GtrA-like protein; Region: GtrA; pfam04138 940190004679 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 940190004680 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 940190004681 ring oligomerisation interface [polypeptide binding]; other site 940190004682 ATP/Mg binding site [chemical binding]; other site 940190004683 stacking interactions; other site 940190004684 hinge regions; other site 940190004685 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 940190004686 oligomerisation interface [polypeptide binding]; other site 940190004687 mobile loop; other site 940190004688 roof hairpin; other site 940190004689 CAAX protease self-immunity; Region: Abi; pfam02517 940190004690 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 940190004691 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 940190004692 CoA binding domain; Region: CoA_binding; pfam02629 940190004693 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 940190004694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004695 Walker A/P-loop; other site 940190004696 ATP binding site [chemical binding]; other site 940190004697 Q-loop/lid; other site 940190004698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 940190004699 ABC transporter signature motif; other site 940190004700 Walker B; other site 940190004701 D-loop; other site 940190004702 ABC transporter; Region: ABC_tran_2; pfam12848 940190004703 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 940190004704 Predicted transcriptional regulators [Transcription]; Region: COG1725 940190004705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 940190004706 DNA-binding site [nucleotide binding]; DNA binding site 940190004707 TrkA-C domain; Region: TrkA_C; pfam02080 940190004708 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 940190004709 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 940190004710 Walker A/P-loop; other site 940190004711 ATP binding site [chemical binding]; other site 940190004712 Q-loop/lid; other site 940190004713 ABC transporter signature motif; other site 940190004714 Walker B; other site 940190004715 D-loop; other site 940190004716 H-loop/switch region; other site 940190004717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 940190004718 potential frameshift: common BLAST hit: gi|29377126|ref|NP_816280.1| glycine betaine/L-proline ABC transporter, glycine 940190004719 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 940190004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004721 dimer interface [polypeptide binding]; other site 940190004722 conserved gate region; other site 940190004723 putative PBP binding loops; other site 940190004724 ABC-ATPase subunit interface; other site 940190004725 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 940190004726 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 940190004727 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 940190004728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 940190004729 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 940190004730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004731 putative PBP binding loops; other site 940190004732 dimer interface [polypeptide binding]; other site 940190004733 ABC-ATPase subunit interface; other site 940190004734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004735 dimer interface [polypeptide binding]; other site 940190004736 conserved gate region; other site 940190004737 putative PBP binding loops; other site 940190004738 ABC-ATPase subunit interface; other site 940190004739 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 940190004740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004741 Walker A/P-loop; other site 940190004742 ATP binding site [chemical binding]; other site 940190004743 Q-loop/lid; other site 940190004744 ABC transporter signature motif; other site 940190004745 Walker B; other site 940190004746 D-loop; other site 940190004747 H-loop/switch region; other site 940190004748 TOBE domain; Region: TOBE_2; pfam08402 940190004749 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 940190004750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004751 non-specific DNA binding site [nucleotide binding]; other site 940190004752 salt bridge; other site 940190004753 sequence-specific DNA binding site [nucleotide binding]; other site 940190004754 Cupin domain; Region: Cupin_2; pfam07883 940190004755 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 940190004756 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 940190004757 NADP binding site [chemical binding]; other site 940190004758 dimer interface [polypeptide binding]; other site 940190004759 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 940190004760 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 940190004761 Flavoprotein; Region: Flavoprotein; pfam02441 940190004762 Predicted membrane protein [Function unknown]; Region: COG4684 940190004763 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 940190004764 FemAB family; Region: FemAB; pfam02388 940190004765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 940190004766 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 940190004767 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 940190004768 dimer interface [polypeptide binding]; other site 940190004769 PYR/PP interface [polypeptide binding]; other site 940190004770 TPP binding site [chemical binding]; other site 940190004771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 940190004772 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 940190004773 TPP-binding site [chemical binding]; other site 940190004774 dimer interface [polypeptide binding]; other site 940190004775 QueT transporter; Region: QueT; pfam06177 940190004776 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 940190004777 AAA domain; Region: AAA_30; pfam13604 940190004778 Family description; Region: UvrD_C_2; pfam13538 940190004779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190004780 catalytic core [active] 940190004781 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 940190004782 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 940190004783 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 940190004784 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 940190004785 DXD motif; other site 940190004786 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 940190004787 primosomal protein DnaI; Reviewed; Region: PRK08939 940190004788 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 940190004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 940190004790 Walker A motif; other site 940190004791 ATP binding site [chemical binding]; other site 940190004792 Walker B motif; other site 940190004793 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 940190004794 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 940190004795 ATP cone domain; Region: ATP-cone; pfam03477 940190004796 dephospho-CoA kinase; Region: TIGR00152 940190004797 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 940190004798 CoA-binding site [chemical binding]; other site 940190004799 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 940190004800 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 940190004801 DNA binding site [nucleotide binding] 940190004802 catalytic residue [active] 940190004803 H2TH interface [polypeptide binding]; other site 940190004804 putative catalytic residues [active] 940190004805 turnover-facilitating residue; other site 940190004806 intercalation triad [nucleotide binding]; other site 940190004807 8OG recognition residue [nucleotide binding]; other site 940190004808 putative reading head residues; other site 940190004809 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 940190004810 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 940190004811 DNA polymerase I; Provisional; Region: PRK05755 940190004812 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 940190004813 active site 940190004814 metal binding site 1 [ion binding]; metal-binding site 940190004815 putative 5' ssDNA interaction site; other site 940190004816 metal binding site 3; metal-binding site 940190004817 metal binding site 2 [ion binding]; metal-binding site 940190004818 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 940190004819 putative DNA binding site [nucleotide binding]; other site 940190004820 putative metal binding site [ion binding]; other site 940190004821 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 940190004822 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 940190004823 active site 940190004824 DNA binding site [nucleotide binding] 940190004825 catalytic site [active] 940190004826 Mga helix-turn-helix domain; Region: Mga; pfam05043 940190004827 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 940190004828 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190004829 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190004830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004831 non-specific DNA binding site [nucleotide binding]; other site 940190004832 salt bridge; other site 940190004833 sequence-specific DNA binding site [nucleotide binding]; other site 940190004834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 940190004835 Transporter associated domain; Region: CorC_HlyC; smart01091 940190004836 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 940190004837 Domain of unknown function DUF21; Region: DUF21; pfam01595 940190004838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 940190004839 cation-transporting ATPase, E1-E2 family 940190004840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 940190004841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 940190004842 salt bridge; other site 940190004843 non-specific DNA binding site [nucleotide binding]; other site 940190004844 sequence-specific DNA binding site [nucleotide binding]; other site 940190004845 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 940190004846 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 940190004847 Amino acid permease; Region: AA_permease_2; pfam13520 940190004848 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 940190004849 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 940190004850 potential frameshift: common BLAST hit: gi|15673652|ref|NP_267826.1| phage infection protein 940190004851 Predicted membrane protein [Function unknown]; Region: COG1511 940190004852 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 940190004853 potential frameshift: common BLAST hit: gi|29375446|ref|NP_814600.1| phage infection protein 940190004854 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 940190004855 dinuclear metal binding motif [ion binding]; other site 940190004856 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 940190004857 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 940190004858 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 940190004859 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 940190004860 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 940190004861 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 940190004862 substrate binding pocket [chemical binding]; other site 940190004863 PemK-like protein; Region: PemK; pfam02452 940190004864 alanine racemase; Reviewed; Region: alr; PRK00053 940190004865 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 940190004866 active site 940190004867 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 940190004868 dimer interface [polypeptide binding]; other site 940190004869 substrate binding site [chemical binding]; other site 940190004870 catalytic residues [active] 940190004871 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 940190004872 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 940190004873 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 940190004874 ATP binding site [chemical binding]; other site 940190004875 Mg++ binding site [ion binding]; other site 940190004876 motif III; other site 940190004877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 940190004878 nucleotide binding region [chemical binding]; other site 940190004879 ATP-binding site [chemical binding]; other site 940190004880 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 940190004881 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 940190004882 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190004883 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 940190004884 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 940190004885 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 940190004886 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 940190004887 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 940190004888 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 940190004889 ATP binding site [chemical binding]; other site 940190004890 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 940190004891 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 940190004892 Sugar specificity; other site 940190004893 Pyrimidine base specificity; other site 940190004894 ATP-binding site [chemical binding]; other site 940190004895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 940190004896 Coenzyme A binding pocket [chemical binding]; other site 940190004897 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 940190004898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190004899 motif II; other site 940190004900 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 940190004901 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 940190004902 5S rRNA interface [nucleotide binding]; other site 940190004903 CTC domain interface [polypeptide binding]; other site 940190004904 L16 interface [polypeptide binding]; other site 940190004905 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 940190004906 Asp23 family; Region: Asp23; pfam03780 940190004907 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 940190004908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004909 dimer interface [polypeptide binding]; other site 940190004910 conserved gate region; other site 940190004911 putative PBP binding loops; other site 940190004912 ABC-ATPase subunit interface; other site 940190004913 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190004914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190004915 Walker A/P-loop; other site 940190004916 ATP binding site [chemical binding]; other site 940190004917 Q-loop/lid; other site 940190004918 ABC transporter signature motif; other site 940190004919 Walker B; other site 940190004920 D-loop; other site 940190004921 H-loop/switch region; other site 940190004922 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 940190004923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 940190004924 substrate binding pocket [chemical binding]; other site 940190004925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 940190004926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 940190004927 membrane-bound complex binding site; other site 940190004928 hinge residues; other site 940190004929 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 940190004930 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 940190004931 HIGH motif; other site 940190004932 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 940190004933 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 940190004934 active site 940190004935 KMSKS motif; other site 940190004936 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 940190004937 tRNA binding surface [nucleotide binding]; other site 940190004938 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 940190004939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190004940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190004941 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190004942 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 940190004943 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 940190004944 active site 940190004945 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 940190004946 Methyltransferase domain; Region: Methyltransf_31; pfam13847 940190004947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 940190004948 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 940190004949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190004950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 940190004951 putative substrate translocation pore; other site 940190004952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190004953 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 940190004954 potential frameshift: common BLAST hit: gi|160879597|ref|YP_001558565.1| 5'-nucleotidase domain-containing protein 940190004955 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 940190004956 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 940190004957 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 940190004958 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 940190004959 active site 940190004960 metal binding site [ion binding]; metal-binding site 940190004961 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 940190004962 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 940190004963 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 940190004964 active site 940190004965 metal binding site [ion binding]; metal-binding site 940190004966 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 940190004967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004968 dimer interface [polypeptide binding]; other site 940190004969 conserved gate region; other site 940190004970 putative PBP binding loops; other site 940190004971 ABC-ATPase subunit interface; other site 940190004972 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 940190004973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190004974 dimer interface [polypeptide binding]; other site 940190004975 conserved gate region; other site 940190004976 putative PBP binding loops; other site 940190004977 ABC-ATPase subunit interface; other site 940190004978 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 940190004979 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 940190004980 Walker A/P-loop; other site 940190004981 ATP binding site [chemical binding]; other site 940190004982 Q-loop/lid; other site 940190004983 ABC transporter signature motif; other site 940190004984 Walker B; other site 940190004985 D-loop; other site 940190004986 H-loop/switch region; other site 940190004987 potential frameshift: common BLAST hit: gi|213690949|ref|YP_002321535.1| phosphonate ABC transporter, periplasmic phosphonate-binding 940190004988 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 940190004989 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 940190004990 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 940190004991 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 940190004992 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 940190004993 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 940190004994 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 940190004995 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 940190004996 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 940190004997 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 940190004998 potential frameshift: common BLAST hit: gi|172056191|ref|YP_001812651.1| metal dependent phosphohydrolase 940190004999 potential frameshift: common BLAST hit: gi|172056191|ref|YP_001812651.1| metal dependent phosphohydrolase 940190005000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 940190005001 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 940190005002 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 940190005003 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 940190005004 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 940190005005 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190005006 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 940190005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190005008 putative substrate translocation pore; other site 940190005009 POT family; Region: PTR2; cl17359 940190005010 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 940190005011 intersubunit interface [polypeptide binding]; other site 940190005012 active site 940190005013 Zn2+ binding site [ion binding]; other site 940190005014 L-rhamnose isomerase; Provisional; Region: PRK01076 940190005015 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 940190005016 potential frameshift: common BLAST hit: gi|29375065|ref|NP_814218.1| rhamnulokinase 940190005017 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 940190005018 nucleotide binding site [chemical binding]; other site 940190005019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 940190005020 nucleotide binding site [chemical binding]; other site 940190005021 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 940190005022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 940190005023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190005024 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 940190005025 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 940190005026 NADP binding site [chemical binding]; other site 940190005027 homodimer interface [polypeptide binding]; other site 940190005028 active site 940190005029 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 940190005030 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 940190005031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 940190005032 substrate binding site [chemical binding]; other site 940190005033 ATP binding site [chemical binding]; other site 940190005034 Transcriptional regulator [Transcription]; Region: IclR; COG1414 940190005035 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 940190005036 Bacterial transcriptional regulator; Region: IclR; pfam01614 940190005037 potential frameshift: common BLAST hit: gi|289578909|ref|YP_003477536.1| xylose isomerase 940190005038 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 940190005039 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 940190005040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190005041 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 940190005042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190005043 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 940190005044 potential frameshift: common BLAST hit: gi|146312090|ref|YP_001177164.1| major facilitator transporter 940190005045 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190005046 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190005047 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 940190005048 dipeptidase PepV; Reviewed; Region: PRK07318 940190005049 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 940190005050 active site 940190005051 metal binding site [ion binding]; metal-binding site 940190005052 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 940190005053 putative substrate binding site [chemical binding]; other site 940190005054 putative ATP binding site [chemical binding]; other site 940190005055 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 940190005056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 940190005057 RNA binding surface [nucleotide binding]; other site 940190005058 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 940190005059 active site 940190005060 uracil binding [chemical binding]; other site 940190005061 stage V sporulation protein B; Region: spore_V_B; TIGR02900 940190005062 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 940190005063 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 940190005064 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 940190005065 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 940190005066 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 940190005067 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 940190005068 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 940190005069 peptide binding site [polypeptide binding]; other site 940190005070 hypothetical protein; Validated; Region: PRK00110 940190005071 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190005072 Predicted integral membrane protein [Function unknown]; Region: COG5652 940190005073 Amb_all domain; Region: Amb_all; smart00656 940190005074 oligoendopeptidase F 940190005075 conserved hypothetical protein; Region: TIGR02328 940190005076 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 940190005077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 940190005078 oxidoreductase; Provisional; Region: PRK07985 940190005079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 940190005080 NAD(P) binding site [chemical binding]; other site 940190005081 active site 940190005082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190005083 S-adenosylmethionine binding site [chemical binding]; other site 940190005084 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 940190005085 Phosphotransferase enzyme family; Region: APH; pfam01636 940190005086 active site 940190005087 substrate binding site [chemical binding]; other site 940190005088 ATP binding site [chemical binding]; other site 940190005089 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 940190005090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 940190005091 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 940190005092 Walker A/P-loop; other site 940190005093 ATP binding site [chemical binding]; other site 940190005094 Q-loop/lid; other site 940190005095 ABC transporter signature motif; other site 940190005096 Walker B; other site 940190005097 D-loop; other site 940190005098 H-loop/switch region; other site 940190005099 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 940190005100 HIT family signature motif; other site 940190005101 catalytic residue [active] 940190005102 YtxH-like protein; Region: YtxH; pfam12732 940190005103 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 940190005104 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 940190005105 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 940190005106 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 940190005107 generic binding surface II; other site 940190005108 generic binding surface I; other site 940190005109 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 940190005110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 940190005111 Zn2+ binding site [ion binding]; other site 940190005112 Mg2+ binding site [ion binding]; other site 940190005113 Uncharacterized conserved protein [Function unknown]; Region: COG4717 940190005114 P-loop containing region of AAA domain; Region: AAA_29; cl17516 940190005115 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 940190005116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 940190005117 active site 940190005118 metal binding site [ion binding]; metal-binding site 940190005119 DNA binding site [nucleotide binding] 940190005120 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 940190005121 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 940190005122 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 940190005123 G1 box; other site 940190005124 putative GEF interaction site [polypeptide binding]; other site 940190005125 GTP/Mg2+ binding site [chemical binding]; other site 940190005126 Switch I region; other site 940190005127 G2 box; other site 940190005128 G3 box; other site 940190005129 Switch II region; other site 940190005130 G4 box; other site 940190005131 G5 box; other site 940190005132 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 940190005133 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 940190005134 Domain of unknown function DUF21; Region: DUF21; pfam01595 940190005135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 940190005136 Transporter associated domain; Region: CorC_HlyC; pfam03471 940190005137 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 940190005138 Domain of unknown function DUF20; Region: UPF0118; pfam01594 940190005139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 940190005140 hypothetical protein; Provisional; Region: PRK13662 940190005141 RecX family; Region: RecX; cl00936 940190005142 TRAM domain; Region: TRAM; pfam01938 940190005143 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 940190005144 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 940190005145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190005146 S-adenosylmethionine binding site [chemical binding]; other site 940190005147 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 940190005148 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 940190005149 dimerization interface [polypeptide binding]; other site 940190005150 DPS ferroxidase diiron center [ion binding]; other site 940190005151 ion pore; other site 940190005152 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 940190005153 methionine sulfoxide reductase A; Provisional; Region: PRK14054 940190005154 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 940190005155 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 940190005156 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 940190005157 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 940190005158 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 940190005159 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 940190005160 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 940190005161 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 940190005162 DNA binding site [nucleotide binding] 940190005163 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 940190005164 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 940190005165 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 940190005166 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 940190005167 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 940190005168 RPB1 interaction site [polypeptide binding]; other site 940190005169 RPB10 interaction site [polypeptide binding]; other site 940190005170 RPB11 interaction site [polypeptide binding]; other site 940190005171 RPB3 interaction site [polypeptide binding]; other site 940190005172 RPB12 interaction site [polypeptide binding]; other site 940190005173 Biotin operon repressor [Transcription]; Region: BirA; COG1654 940190005174 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 940190005175 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 940190005176 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 940190005177 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 940190005178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 940190005179 NAD binding site [chemical binding]; other site 940190005180 substrate binding site [chemical binding]; other site 940190005181 putative active site [active] 940190005182 potential frameshift: common BLAST hit: gi|261820229|ref|YP_003258335.1| Rhamnogalacturonate lyase 940190005183 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 940190005184 Ca binding site [ion binding]; other site 940190005185 substrate binding site [chemical binding]; other site 940190005186 potential frameshift: common BLAST hit: gi|251790809|ref|YP_003005530.1| Rhamnogalacturonate lyase 940190005187 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 940190005188 catalytic site [active] 940190005189 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 940190005190 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 940190005191 core dimer interface [polypeptide binding]; other site 940190005192 peripheral dimer interface [polypeptide binding]; other site 940190005193 L10 interface [polypeptide binding]; other site 940190005194 L11 interface [polypeptide binding]; other site 940190005195 putative EF-Tu interaction site [polypeptide binding]; other site 940190005196 putative EF-G interaction site [polypeptide binding]; other site 940190005197 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 940190005198 23S rRNA interface [nucleotide binding]; other site 940190005199 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 940190005200 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 940190005201 mRNA/rRNA interface [nucleotide binding]; other site 940190005202 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 940190005203 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 940190005204 23S rRNA interface [nucleotide binding]; other site 940190005205 L7/L12 interface [polypeptide binding]; other site 940190005206 putative thiostrepton binding site; other site 940190005207 L25 interface [polypeptide binding]; other site 940190005208 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 940190005209 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 940190005210 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 940190005211 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 940190005212 putative homodimer interface [polypeptide binding]; other site 940190005213 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 940190005214 heterodimer interface [polypeptide binding]; other site 940190005215 homodimer interface [polypeptide binding]; other site 940190005216 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 940190005217 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 940190005218 FOG: CBS domain [General function prediction only]; Region: COG0517 940190005219 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 940190005220 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 940190005221 FAD binding domain; Region: FAD_binding_4; pfam01565 940190005222 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 940190005223 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 940190005224 active site 940190005225 putative catalytic site [active] 940190005226 DNA binding site [nucleotide binding] 940190005227 putative phosphate binding site [ion binding]; other site 940190005228 metal binding site A [ion binding]; metal-binding site 940190005229 AP binding site [nucleotide binding]; other site 940190005230 metal binding site B [ion binding]; metal-binding site 940190005231 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 940190005232 active site 940190005233 catalytic site [active] 940190005234 substrate binding site [chemical binding]; other site 940190005235 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 940190005236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 940190005237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 940190005238 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 940190005239 catalytic residue [active] 940190005240 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 940190005241 peroxiredoxin; Region: AhpC; TIGR03137 940190005242 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 940190005243 dimer interface [polypeptide binding]; other site 940190005244 decamer (pentamer of dimers) interface [polypeptide binding]; other site 940190005245 catalytic triad [active] 940190005246 peroxidatic and resolving cysteines [active] 940190005247 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 940190005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 940190005249 S-adenosylmethionine binding site [chemical binding]; other site 940190005250 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 940190005251 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 940190005252 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 940190005253 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 940190005254 putative hydrolase; Provisional; Region: PRK02113 940190005255 Protein of unknown function (DUF975); Region: DUF975; cl10504 940190005256 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 940190005257 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 940190005258 oligomer interface [polypeptide binding]; other site 940190005259 active site 940190005260 metal binding site [ion binding]; metal-binding site 940190005261 trigger factor; Provisional; Region: tig; PRK01490 940190005262 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 940190005263 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 940190005264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 940190005265 metal binding site [ion binding]; metal-binding site 940190005266 Protein of unknown function DUF72; Region: DUF72; pfam01904 940190005267 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 940190005268 active site 940190005269 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 940190005270 active site 2 [active] 940190005271 active site 1 [active] 940190005272 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 940190005273 trimer interface [polypeptide binding]; other site 940190005274 active site 940190005275 G bulge; other site 940190005276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 940190005277 metal-binding site [ion binding] 940190005278 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 940190005279 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 940190005280 metal-binding site [ion binding] 940190005281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 940190005282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 940190005283 metal-binding site [ion binding] 940190005284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 940190005285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 940190005286 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 940190005287 nucleoside/Zn binding site; other site 940190005288 dimer interface [polypeptide binding]; other site 940190005289 catalytic motif [active] 940190005290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190005291 catalytic core [active] 940190005292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 940190005293 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 940190005294 beta-galactosidase; Region: BGL; TIGR03356 940190005295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190005296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190005297 active site 940190005298 phosphorylation site [posttranslational modification] 940190005299 intermolecular recognition site; other site 940190005300 dimerization interface [polypeptide binding]; other site 940190005301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190005302 DNA binding site [nucleotide binding] 940190005303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 940190005304 dimer interface [polypeptide binding]; other site 940190005305 phosphorylation site [posttranslational modification] 940190005306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 940190005307 ATP binding site [chemical binding]; other site 940190005308 Mg2+ binding site [ion binding]; other site 940190005309 G-X-G motif; other site 940190005310 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 940190005311 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 940190005312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 940190005313 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 940190005314 active site 940190005315 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 940190005316 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 940190005317 GTP-binding protein YchF; Reviewed; Region: PRK09601 940190005318 YchF GTPase; Region: YchF; cd01900 940190005319 G1 box; other site 940190005320 GTP/Mg2+ binding site [chemical binding]; other site 940190005321 Switch I region; other site 940190005322 G2 box; other site 940190005323 Switch II region; other site 940190005324 G3 box; other site 940190005325 G4 box; other site 940190005326 G5 box; other site 940190005327 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 940190005328 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 940190005329 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 940190005330 ParB-like nuclease domain; Region: ParBc; pfam02195 940190005331 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 940190005332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 940190005333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 940190005334 Magnesium ion binding site [ion binding]; other site 940190005335 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 940190005336 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 940190005337 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 940190005338 Nucleoside recognition; Region: Gate; pfam07670 940190005339 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 940190005340 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 940190005341 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 940190005342 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 940190005343 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 940190005344 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 940190005345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 940190005346 DNA binding residues [nucleotide binding] 940190005347 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 940190005348 phosphopentomutase; Provisional; Region: PRK05362 940190005349 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 940190005350 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 940190005351 intersubunit interface [polypeptide binding]; other site 940190005352 active site 940190005353 catalytic residue [active] 940190005354 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 940190005355 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 940190005356 active site 940190005357 catalytic residue [active] 940190005358 dimer interface [polypeptide binding]; other site 940190005359 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 940190005360 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 940190005361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190005362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005363 Walker A/P-loop; other site 940190005364 ATP binding site [chemical binding]; other site 940190005365 Q-loop/lid; other site 940190005366 ABC transporter signature motif; other site 940190005367 Walker B; other site 940190005368 D-loop; other site 940190005369 H-loop/switch region; other site 940190005370 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 940190005371 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 940190005372 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 940190005373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 940190005374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 940190005375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 940190005376 G1 box; other site 940190005377 GTP/Mg2+ binding site [chemical binding]; other site 940190005378 Switch I region; other site 940190005379 G2 box; other site 940190005380 Switch II region; other site 940190005381 G3 box; other site 940190005382 G4 box; other site 940190005383 G5 box; other site 940190005384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 940190005385 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 940190005386 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 940190005387 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 940190005388 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 940190005389 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 940190005390 G-X-X-G motif; other site 940190005391 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 940190005392 RxxxH motif; other site 940190005393 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 940190005394 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 940190005395 ribonuclease P; Reviewed; Region: rnpA; PRK00499 940190005396 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 940190005397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 940190005398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 940190005399 P-loop; other site 940190005400 Magnesium ion binding site [ion binding]; other site 940190005401 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 940190005402 Magnesium ion binding site [ion binding]; other site 940190005403 potential frameshift: common BLAST hit: gi|157150811|ref|YP_001451066.1| ABC transporter-like protein CylA 940190005404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005405 Walker A/P-loop; other site 940190005406 ATP binding site [chemical binding]; other site 940190005407 Q-loop/lid; other site 940190005408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190005409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005410 ABC transporter signature motif; other site 940190005411 Walker B; other site 940190005412 D-loop; other site 940190005413 H-loop/switch region; other site 940190005414 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190005415 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 940190005416 Walker A/P-loop; other site 940190005417 ATP binding site [chemical binding]; other site 940190005418 Q-loop/lid; other site 940190005419 ABC transporter signature motif; other site 940190005420 Walker B; other site 940190005421 D-loop; other site 940190005422 H-loop/switch region; other site 940190005423 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 940190005424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190005425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190005426 Walker A/P-loop; other site 940190005427 ATP binding site [chemical binding]; other site 940190005428 Q-loop/lid; other site 940190005429 ABC transporter signature motif; other site 940190005430 Walker B; other site 940190005431 D-loop; other site 940190005432 H-loop/switch region; other site 940190005433 Uncharacterized conserved protein [Function unknown]; Region: COG1359 940190005434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005435 Walker A/P-loop; other site 940190005436 ATP binding site [chemical binding]; other site 940190005437 Q-loop/lid; other site 940190005438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005439 ABC transporter signature motif; other site 940190005440 Walker B; other site 940190005441 D-loop; other site 940190005442 H-loop/switch region; other site 940190005443 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 940190005444 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 940190005445 active site 940190005446 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190005447 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 940190005448 Walker A/P-loop; other site 940190005449 ATP binding site [chemical binding]; other site 940190005450 Q-loop/lid; other site 940190005451 ABC transporter signature motif; other site 940190005452 Walker B; other site 940190005453 D-loop; other site 940190005454 H-loop/switch region; other site 940190005455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005456 Walker A/P-loop; other site 940190005457 ATP binding site [chemical binding]; other site 940190005458 Q-loop/lid; other site 940190005459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005460 ABC transporter signature motif; other site 940190005461 Walker B; other site 940190005462 D-loop; other site 940190005463 H-loop/switch region; other site 940190005464 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 940190005465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 940190005466 conserved hypothetical protein 940190005467 MazG related NTP pyrophosphohydrolase 940190005468 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 940190005469 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 940190005470 Walker A/P-loop; other site 940190005471 ATP binding site [chemical binding]; other site 940190005472 Q-loop/lid; other site 940190005473 ABC transporter signature motif; other site 940190005474 Walker B; other site 940190005475 D-loop; other site 940190005476 H-loop/switch region; other site 940190005477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 940190005478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 940190005479 active site 940190005480 phosphorylation site [posttranslational modification] 940190005481 intermolecular recognition site; other site 940190005482 dimerization interface [polypeptide binding]; other site 940190005483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 940190005484 DNA binding site [nucleotide binding] 940190005485 sensor protein VanS 940190005486 Protein of unknown function (DUF554); Region: DUF554; pfam04474 940190005487 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 940190005488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 940190005489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 940190005490 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 940190005491 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 940190005492 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 940190005493 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 940190005494 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 940190005495 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 940190005496 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 940190005497 Endodeoxyribonuclease RusA; Region: RusA; cl01885 940190005498 Endodeoxyribonuclease RusA; Region: RusA; cl01885 940190005499 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190005500 active site 940190005501 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190005502 beta-phosphoglucomutase; Region: bPGM; TIGR01990 940190005503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 940190005504 motif II; other site 940190005505 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 940190005506 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 940190005507 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 940190005508 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 940190005509 Cupin domain; Region: Cupin_2; cl17218 940190005510 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 940190005511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 940190005512 Predicted transcriptional regulators [Transcription]; Region: COG1695 940190005513 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 940190005514 Predicted membrane protein [Function unknown]; Region: COG4709 940190005515 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 940190005516 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 940190005517 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 940190005518 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 940190005519 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 940190005520 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 940190005521 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 940190005522 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 940190005523 beta-galactosidase; Region: BGL; TIGR03356 940190005524 Transcriptional regulators [Transcription]; Region: MarR; COG1846 940190005525 MarR family; Region: MarR_2; pfam12802 940190005526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 940190005527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 940190005528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 940190005529 Walker A/P-loop; other site 940190005530 ATP binding site [chemical binding]; other site 940190005531 Q-loop/lid; other site 940190005532 ABC transporter signature motif; other site 940190005533 Walker B; other site 940190005534 D-loop; other site 940190005535 H-loop/switch region; other site 940190005536 NADH-dependent oxidoreductase 940190005537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190005538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 940190005539 putative substrate translocation pore; other site 940190005540 legume lectins; Region: lectin_L-type; cd01951 940190005541 carbohydrate binding site [chemical binding]; other site 940190005542 metal binding site [ion binding]; metal-binding site 940190005543 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190005544 domain interaction interfaces [polypeptide binding]; other site 940190005545 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190005546 domain interaction interfaces [polypeptide binding]; other site 940190005547 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190005548 domain interaction interfaces [polypeptide binding]; other site 940190005549 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 940190005550 domain interaction interfaces [polypeptide binding]; other site 940190005551 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 940190005552 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 940190005553 Predicted membrane protein [Function unknown]; Region: COG2323 940190005554 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 940190005555 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 940190005556 dimer interface [polypeptide binding]; other site 940190005557 active site 940190005558 putative acyltransferase; Provisional; Region: PRK05790 940190005559 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 940190005560 dimer interface [polypeptide binding]; other site 940190005561 active site 940190005562 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 940190005563 homodimer interface [polypeptide binding]; other site 940190005564 catalytic residues [active] 940190005565 NAD binding site [chemical binding]; other site 940190005566 substrate binding pocket [chemical binding]; other site 940190005567 flexible flap; other site 940190005568 Protein of unknown function (DUF969); Region: DUF969; pfam06149 940190005569 Predicted membrane protein [Function unknown]; Region: COG3817 940190005570 Protein of unknown function (DUF979); Region: DUF979; pfam06166 940190005571 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 940190005572 putative substrate binding pocket [chemical binding]; other site 940190005573 AC domain interface; other site 940190005574 catalytic triad [active] 940190005575 AB domain interface; other site 940190005576 interchain disulfide; other site 940190005577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190005578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190005579 Walker A/P-loop; other site 940190005580 ATP binding site [chemical binding]; other site 940190005581 Q-loop/lid; other site 940190005582 ABC transporter signature motif; other site 940190005583 Walker B; other site 940190005584 D-loop; other site 940190005585 H-loop/switch region; other site 940190005586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190005587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190005588 Walker A/P-loop; other site 940190005589 ATP binding site [chemical binding]; other site 940190005590 Q-loop/lid; other site 940190005591 ABC transporter signature motif; other site 940190005592 Walker B; other site 940190005593 D-loop; other site 940190005594 H-loop/switch region; other site 940190005595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 940190005596 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 940190005597 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 940190005598 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 940190005599 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 940190005600 Glucuronate isomerase; Region: UxaC; pfam02614 940190005601 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 940190005602 sugar ABC transporter 940190005603 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 940190005604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190005605 dimer interface [polypeptide binding]; other site 940190005606 conserved gate region; other site 940190005607 putative PBP binding loops; other site 940190005608 ABC-ATPase subunit interface; other site 940190005609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190005610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190005611 dimer interface [polypeptide binding]; other site 940190005612 conserved gate region; other site 940190005613 putative PBP binding loops; other site 940190005614 ABC-ATPase subunit interface; other site 940190005615 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 940190005616 Protein of unknown function (DUF1686); Region: DUF1686; pfam07937 940190005617 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 940190005618 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 940190005619 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 940190005620 seryl-tRNA synthetase; Provisional; Region: PRK05431 940190005621 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 940190005622 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 940190005623 dimer interface [polypeptide binding]; other site 940190005624 active site 940190005625 motif 1; other site 940190005626 motif 2; other site 940190005627 motif 3; other site 940190005628 seryl-tRNA synthetase; Provisional; Region: PRK05431 940190005629 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 940190005630 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 940190005631 dimer interface [polypeptide binding]; other site 940190005632 active site 940190005633 motif 1; other site 940190005634 motif 2; other site 940190005635 motif 3; other site 940190005636 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 940190005637 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 940190005638 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 940190005639 Protein of unknown function (DUF1686); Region: DUF1686; pfam07937 940190005640 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 940190005641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 940190005642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190005643 dimer interface [polypeptide binding]; other site 940190005644 conserved gate region; other site 940190005645 putative PBP binding loops; other site 940190005646 ABC-ATPase subunit interface; other site 940190005647 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 940190005648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 940190005649 dimer interface [polypeptide binding]; other site 940190005650 conserved gate region; other site 940190005651 putative PBP binding loops; other site 940190005652 ABC-ATPase subunit interface; other site 940190005653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 940190005654 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 940190005655 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 940190005656 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 940190005657 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 940190005658 WxL domain surface cell wall-binding; Region: WxL; pfam13731 940190005659 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 940190005660 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 940190005661 manganese transport protein MntH; Reviewed; Region: PRK00701 940190005662 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 940190005663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 940190005664 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 940190005665 Walker A/P-loop; other site 940190005666 ATP binding site [chemical binding]; other site 940190005667 Q-loop/lid; other site 940190005668 ABC transporter signature motif; other site 940190005669 Walker B; other site 940190005670 D-loop; other site 940190005671 H-loop/switch region; other site 940190005672 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 940190005673 FtsX-like permease family; Region: FtsX; pfam02687 940190005674 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 940190005675 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 940190005676 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 940190005677 Coenzyme A transferase; Region: CoA_trans; cl17247 940190005678 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 940190005679 citrate lyase subunit gamma; Provisional; Region: PRK13253 940190005680 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 940190005681 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 940190005682 active site 940190005683 nucleotide binding site [chemical binding]; other site 940190005684 HIGH motif; other site 940190005685 KMSKS motif; other site 940190005686 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 940190005687 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 940190005688 Malic enzyme, N-terminal domain; Region: malic; pfam00390 940190005689 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 940190005690 putative NAD(P) binding site [chemical binding]; other site 940190005691 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 940190005692 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 940190005693 Predicted transcriptional regulator [Transcription]; Region: COG1959 940190005694 Transcriptional regulator; Region: Rrf2; pfam02082 940190005695 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 940190005696 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 940190005697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 940190005698 putative substrate translocation pore; other site 940190005699 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 940190005700 active site 940190005701 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 940190005702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 940190005703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 940190005704 homodimer interface [polypeptide binding]; other site 940190005705 catalytic residue [active] 940190005706 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 940190005707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 940190005708 catalytic residue [active] 940190005709 Viral enhancin protein; Region: Enhancin; pfam03272 940190005710 Peptidase M60-like family; Region: M60-like; pfam13402 940190005711 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 940190005712 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 940190005713 potential frameshift: common BLAST hit: gi|258540983|ref|YP_003175482.1| oligogalacturonide transporter 940190005714 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 940190005715 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 940190005716 Replicase family; Region: Replicase; pfam03090 940190005717 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708