-- dump date 20140619_140637 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1090974000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1090974000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1090974000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974000004 Walker A motif; other site 1090974000005 ATP binding site [chemical binding]; other site 1090974000006 Walker B motif; other site 1090974000007 arginine finger; other site 1090974000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1090974000009 DnaA box-binding interface [nucleotide binding]; other site 1090974000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1090974000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1090974000012 putative DNA binding surface [nucleotide binding]; other site 1090974000013 dimer interface [polypeptide binding]; other site 1090974000014 beta-clamp/clamp loader binding surface; other site 1090974000015 beta-clamp/translesion DNA polymerase binding surface; other site 1090974000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1090974000017 recombination protein F; Reviewed; Region: recF; PRK00064 1090974000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1090974000019 Walker A/P-loop; other site 1090974000020 ATP binding site [chemical binding]; other site 1090974000021 Q-loop/lid; other site 1090974000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974000023 ABC transporter signature motif; other site 1090974000024 Walker B; other site 1090974000025 D-loop; other site 1090974000026 H-loop/switch region; other site 1090974000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1090974000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974000029 Mg2+ binding site [ion binding]; other site 1090974000030 G-X-G motif; other site 1090974000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1090974000032 anchoring element; other site 1090974000033 dimer interface [polypeptide binding]; other site 1090974000034 ATP binding site [chemical binding]; other site 1090974000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1090974000036 active site 1090974000037 putative metal-binding site [ion binding]; other site 1090974000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1090974000039 DNA gyrase subunit A; Validated; Region: PRK05560 1090974000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1090974000041 CAP-like domain; other site 1090974000042 active site 1090974000043 primary dimer interface [polypeptide binding]; other site 1090974000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1090974000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1090974000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1090974000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1090974000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1090974000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1090974000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1090974000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1090974000052 dimer interface [polypeptide binding]; other site 1090974000053 ssDNA binding site [nucleotide binding]; other site 1090974000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1090974000055 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1090974000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1090974000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1090974000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1090974000059 DHH family; Region: DHH; pfam01368 1090974000060 DHHA1 domain; Region: DHHA1; pfam02272 1090974000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1090974000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1090974000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1090974000064 replicative DNA helicase; Provisional; Region: PRK05748 1090974000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1090974000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1090974000067 Walker A motif; other site 1090974000068 ATP binding site [chemical binding]; other site 1090974000069 Walker B motif; other site 1090974000070 DNA binding loops [nucleotide binding] 1090974000071 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1090974000072 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1090974000073 GDP-binding site [chemical binding]; other site 1090974000074 ACT binding site; other site 1090974000075 IMP binding site; other site 1090974000076 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1090974000077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974000078 Walker A/P-loop; other site 1090974000079 ATP binding site [chemical binding]; other site 1090974000080 Q-loop/lid; other site 1090974000081 ABC transporter signature motif; other site 1090974000082 Walker B; other site 1090974000083 D-loop; other site 1090974000084 H-loop/switch region; other site 1090974000085 ABC transporter; Region: ABC_tran_2; pfam12848 1090974000086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1090974000087 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1090974000088 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1090974000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974000090 Walker A motif; other site 1090974000091 ATP binding site [chemical binding]; other site 1090974000092 Walker B motif; other site 1090974000093 arginine finger; other site 1090974000094 Transcriptional antiterminator [Transcription]; Region: COG3933 1090974000095 PRD domain; Region: PRD; pfam00874 1090974000096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1090974000097 active pocket/dimerization site; other site 1090974000098 active site 1090974000099 phosphorylation site [posttranslational modification] 1090974000100 PRD domain; Region: PRD; pfam00874 1090974000101 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1090974000102 active site 1090974000103 phosphorylation site [posttranslational modification] 1090974000104 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1090974000105 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1090974000106 active pocket/dimerization site; other site 1090974000107 active site 1090974000108 phosphorylation site [posttranslational modification] 1090974000109 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1090974000110 active site 1090974000111 phosphorylation site [posttranslational modification] 1090974000112 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1090974000113 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1090974000114 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1090974000115 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1090974000116 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1090974000117 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1090974000118 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1090974000119 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1090974000120 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1090974000121 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 1090974000122 active site 1090974000123 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1090974000124 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1090974000125 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1090974000126 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1090974000127 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1090974000128 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1090974000129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974000130 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1090974000131 Predicted membrane protein [Function unknown]; Region: COG3463 1090974000132 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1090974000133 trimer interface [polypeptide binding]; other site 1090974000134 active site 1090974000135 DNA repair protein RadA; Provisional; Region: PRK11823 1090974000136 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1090974000137 Walker A motif/ATP binding site; other site 1090974000138 ATP binding site [chemical binding]; other site 1090974000139 Walker B motif; other site 1090974000140 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1090974000141 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1090974000142 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1090974000143 putative active site [active] 1090974000144 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1090974000145 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1090974000146 HIGH motif; other site 1090974000147 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1090974000148 active site 1090974000149 KMSKS motif; other site 1090974000150 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1090974000151 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1090974000152 active site 1090974000153 HIGH motif; other site 1090974000154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1090974000155 KMSKS motif; other site 1090974000156 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1090974000157 tRNA binding surface [nucleotide binding]; other site 1090974000158 anticodon binding site; other site 1090974000159 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1090974000160 active site 1090974000161 metal binding site [ion binding]; metal-binding site 1090974000162 dimerization interface [polypeptide binding]; other site 1090974000163 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1090974000164 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1090974000165 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1090974000166 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1090974000167 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 1090974000168 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1090974000169 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1090974000170 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1090974000171 intersubunit interface [polypeptide binding]; other site 1090974000172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974000173 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1090974000174 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1090974000175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974000176 ABC-ATPase subunit interface; other site 1090974000177 dimer interface [polypeptide binding]; other site 1090974000178 putative PBP binding regions; other site 1090974000179 pur operon repressor; Provisional; Region: PRK09213 1090974000180 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1090974000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974000182 active site 1090974000183 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 1090974000184 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1090974000185 putative active site [active] 1090974000186 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1090974000187 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1090974000188 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1090974000189 elongation factor P; Validated; Region: PRK00529 1090974000190 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1090974000191 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1090974000192 RNA binding site [nucleotide binding]; other site 1090974000193 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1090974000194 RNA binding site [nucleotide binding]; other site 1090974000195 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1090974000196 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1090974000197 active site 1090974000198 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1090974000199 active site 1090974000200 catalytic site [active] 1090974000201 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1090974000202 23S rRNA interface [nucleotide binding]; other site 1090974000203 L3 interface [polypeptide binding]; other site 1090974000204 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1090974000205 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1090974000206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974000207 active site 1090974000208 phosphorylation site [posttranslational modification] 1090974000209 intermolecular recognition site; other site 1090974000210 dimerization interface [polypeptide binding]; other site 1090974000211 LytTr DNA-binding domain; Region: LytTR; cl04498 1090974000212 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1090974000213 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1090974000214 ATP binding site [chemical binding]; other site 1090974000215 Mg2+ binding site [ion binding]; other site 1090974000216 G-X-G motif; other site 1090974000217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1090974000218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1090974000219 Walker A/P-loop; other site 1090974000220 ATP binding site [chemical binding]; other site 1090974000221 Q-loop/lid; other site 1090974000222 ABC transporter signature motif; other site 1090974000223 Walker B; other site 1090974000224 D-loop; other site 1090974000225 H-loop/switch region; other site 1090974000226 topology modulation protein; Reviewed; Region: PRK08118 1090974000227 AAA domain; Region: AAA_17; pfam13207 1090974000228 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1090974000229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1090974000230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974000231 non-specific DNA binding site [nucleotide binding]; other site 1090974000232 salt bridge; other site 1090974000233 sequence-specific DNA binding site [nucleotide binding]; other site 1090974000234 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1090974000235 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1090974000236 trimer interface [polypeptide binding]; other site 1090974000237 active site 1090974000238 substrate binding site [chemical binding]; other site 1090974000239 CoA binding site [chemical binding]; other site 1090974000240 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1090974000241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1090974000242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974000243 active site 1090974000244 phosphorylation site [posttranslational modification] 1090974000245 intermolecular recognition site; other site 1090974000246 dimerization interface [polypeptide binding]; other site 1090974000247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1090974000248 DNA binding residues [nucleotide binding] 1090974000249 dimerization interface [polypeptide binding]; other site 1090974000250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1090974000251 Histidine kinase; Region: HisKA_3; pfam07730 1090974000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974000253 ATP binding site [chemical binding]; other site 1090974000254 Mg2+ binding site [ion binding]; other site 1090974000255 G-X-G motif; other site 1090974000256 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1090974000257 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1090974000258 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974000259 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1090974000260 Walker A/P-loop; other site 1090974000261 ATP binding site [chemical binding]; other site 1090974000262 Q-loop/lid; other site 1090974000263 ABC transporter signature motif; other site 1090974000264 Walker B; other site 1090974000265 D-loop; other site 1090974000266 H-loop/switch region; other site 1090974000267 glycerate kinase; Region: TIGR00045 1090974000268 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1090974000269 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974000270 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974000271 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974000272 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974000273 legume lectins; Region: lectin_L-type; cd01951 1090974000274 homotetramer interaction site [polypeptide binding]; other site 1090974000275 carbohydrate binding site [chemical binding]; other site 1090974000276 metal binding site [ion binding]; metal-binding site 1090974000277 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1090974000278 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974000279 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974000280 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1090974000281 Walker A/P-loop; other site 1090974000282 ATP binding site [chemical binding]; other site 1090974000283 Q-loop/lid; other site 1090974000284 ABC transporter signature motif; other site 1090974000285 Walker B; other site 1090974000286 D-loop; other site 1090974000287 H-loop/switch region; other site 1090974000288 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1090974000289 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1090974000290 GI:332685628; hypothetical protein 1090974000291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974000292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974000293 Walker A/P-loop; other site 1090974000294 ATP binding site [chemical binding]; other site 1090974000295 Q-loop/lid; other site 1090974000296 ABC transporter signature motif; other site 1090974000297 Walker B; other site 1090974000298 D-loop; other site 1090974000299 H-loop/switch region; other site 1090974000300 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1090974000301 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1090974000302 NAD binding site [chemical binding]; other site 1090974000303 substrate binding site [chemical binding]; other site 1090974000304 catalytic Zn binding site [ion binding]; other site 1090974000305 tetramer interface [polypeptide binding]; other site 1090974000306 structural Zn binding site [ion binding]; other site 1090974000307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974000308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974000309 dimer interface [polypeptide binding]; other site 1090974000310 phosphorylation site [posttranslational modification] 1090974000311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974000312 ATP binding site [chemical binding]; other site 1090974000313 Mg2+ binding site [ion binding]; other site 1090974000314 G-X-G motif; other site 1090974000315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974000316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974000317 active site 1090974000318 phosphorylation site [posttranslational modification] 1090974000319 intermolecular recognition site; other site 1090974000320 dimerization interface [polypeptide binding]; other site 1090974000321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974000322 DNA binding site [nucleotide binding] 1090974000323 Predicted secreted protein [Function unknown]; Region: COG4086 1090974000324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974000325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974000327 dimer interface [polypeptide binding]; other site 1090974000328 conserved gate region; other site 1090974000329 putative PBP binding loops; other site 1090974000330 ABC-ATPase subunit interface; other site 1090974000331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974000333 dimer interface [polypeptide binding]; other site 1090974000334 conserved gate region; other site 1090974000335 putative PBP binding loops; other site 1090974000336 ABC-ATPase subunit interface; other site 1090974000337 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1090974000338 active site 1090974000339 potential frameshift: common BLAST hit: gi|332685640|ref|YP_004455414.1| alpha-N-arabinofuranosidase 1090974000340 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1090974000341 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1090974000342 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1090974000343 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1090974000344 dimer interface [polypeptide binding]; other site 1090974000345 FMN binding site [chemical binding]; other site 1090974000346 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1090974000347 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1090974000348 NAD binding site [chemical binding]; other site 1090974000349 homotetramer interface [polypeptide binding]; other site 1090974000350 homodimer interface [polypeptide binding]; other site 1090974000351 substrate binding site [chemical binding]; other site 1090974000352 active site 1090974000353 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1090974000354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1090974000355 dimer interface [polypeptide binding]; other site 1090974000356 active site 1090974000357 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1090974000358 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1090974000359 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1090974000360 Substrate binding site; other site 1090974000361 Mg++ binding site; other site 1090974000362 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1090974000363 active site 1090974000364 substrate binding site [chemical binding]; other site 1090974000365 CoA binding site [chemical binding]; other site 1090974000366 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1090974000367 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1090974000368 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974000369 active site 1090974000370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974000371 Coenzyme A binding pocket [chemical binding]; other site 1090974000372 Predicted small secreted protein [Function unknown]; Region: COG5584 1090974000373 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1090974000374 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1090974000375 oligomer interface [polypeptide binding]; other site 1090974000376 active site 1090974000377 metal binding site [ion binding]; metal-binding site 1090974000378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1090974000379 catalytic residues [active] 1090974000380 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1090974000381 Ligand Binding Site [chemical binding]; other site 1090974000382 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1090974000383 putative tRNA-binding site [nucleotide binding]; other site 1090974000384 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1090974000385 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1090974000386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1090974000387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1090974000388 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1090974000389 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1090974000390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1090974000391 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1090974000392 Helix-turn-helix domain; Region: HTH_25; pfam13413 1090974000393 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1090974000394 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1090974000395 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1090974000396 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1090974000397 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1090974000398 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1090974000399 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1090974000400 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1090974000401 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1090974000402 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1090974000403 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1090974000404 putative translocon binding site; other site 1090974000405 protein-rRNA interface [nucleotide binding]; other site 1090974000406 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1090974000407 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1090974000408 G-X-X-G motif; other site 1090974000409 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1090974000410 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1090974000411 23S rRNA interface [nucleotide binding]; other site 1090974000412 5S rRNA interface [nucleotide binding]; other site 1090974000413 putative antibiotic binding site [chemical binding]; other site 1090974000414 L25 interface [polypeptide binding]; other site 1090974000415 L27 interface [polypeptide binding]; other site 1090974000416 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1090974000417 23S rRNA interface [nucleotide binding]; other site 1090974000418 putative translocon interaction site; other site 1090974000419 signal recognition particle (SRP54) interaction site; other site 1090974000420 L23 interface [polypeptide binding]; other site 1090974000421 trigger factor interaction site; other site 1090974000422 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1090974000423 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1090974000424 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1090974000425 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1090974000426 RNA binding site [nucleotide binding]; other site 1090974000427 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1090974000428 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1090974000429 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1090974000430 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1090974000431 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1090974000432 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1090974000433 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1090974000434 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1090974000435 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1090974000436 5S rRNA interface [nucleotide binding]; other site 1090974000437 L27 interface [polypeptide binding]; other site 1090974000438 23S rRNA interface [nucleotide binding]; other site 1090974000439 L5 interface [polypeptide binding]; other site 1090974000440 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1090974000441 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1090974000442 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1090974000443 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1090974000444 23S rRNA binding site [nucleotide binding]; other site 1090974000445 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1090974000446 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1090974000447 SecY translocase; Region: SecY; pfam00344 1090974000448 adenylate kinase; Reviewed; Region: adk; PRK00279 1090974000449 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1090974000450 AMP-binding site [chemical binding]; other site 1090974000451 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1090974000452 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1090974000453 rRNA binding site [nucleotide binding]; other site 1090974000454 predicted 30S ribosome binding site; other site 1090974000455 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1090974000456 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1090974000457 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1090974000458 30S ribosomal protein S11; Validated; Region: PRK05309 1090974000459 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1090974000460 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1090974000461 alphaNTD homodimer interface [polypeptide binding]; other site 1090974000462 alphaNTD - beta interaction site [polypeptide binding]; other site 1090974000463 alphaNTD - beta' interaction site [polypeptide binding]; other site 1090974000464 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1090974000465 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1090974000466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974000467 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1090974000468 Q-loop/lid; other site 1090974000469 ABC transporter signature motif; other site 1090974000470 Walker B; other site 1090974000471 D-loop; other site 1090974000472 H-loop/switch region; other site 1090974000473 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1090974000474 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1090974000475 Walker A/P-loop; other site 1090974000476 ATP binding site [chemical binding]; other site 1090974000477 Q-loop/lid; other site 1090974000478 ABC transporter signature motif; other site 1090974000479 Walker B; other site 1090974000480 D-loop; other site 1090974000481 H-loop/switch region; other site 1090974000482 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1090974000483 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1090974000484 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1090974000485 dimerization interface 3.5A [polypeptide binding]; other site 1090974000486 active site 1090974000487 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1090974000488 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1090974000489 GI:332685700; branched-chain amino acid transport system carrier protein 1090974000490 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1090974000491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974000492 ATP binding site [chemical binding]; other site 1090974000493 Mg2+ binding site [ion binding]; other site 1090974000494 G-X-G motif; other site 1090974000495 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1090974000496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974000497 active site 1090974000498 phosphorylation site [posttranslational modification] 1090974000499 intermolecular recognition site; other site 1090974000500 dimerization interface [polypeptide binding]; other site 1090974000501 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 1090974000502 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1090974000503 putative homodimer interface [polypeptide binding]; other site 1090974000504 putative ligand binding site [chemical binding]; other site 1090974000505 putative NAD binding site [chemical binding]; other site 1090974000506 catalytic site [active] 1090974000507 Membrane transport protein; Region: Mem_trans; pfam03547 1090974000508 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1090974000509 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1090974000510 NAD binding site [chemical binding]; other site 1090974000511 homodimer interface [polypeptide binding]; other site 1090974000512 active site 1090974000513 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1090974000514 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1090974000515 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1090974000516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974000517 catalytic residue [active] 1090974000518 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1090974000519 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1090974000520 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1090974000521 Ligand Binding Site [chemical binding]; other site 1090974000522 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1090974000523 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1090974000524 CoA binding domain; Region: CoA_binding; pfam02629 1090974000525 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1090974000526 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1090974000527 active site 1090974000528 HIGH motif; other site 1090974000529 nucleotide binding site [chemical binding]; other site 1090974000530 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1090974000531 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1090974000532 active site 1090974000533 KMSKS motif; other site 1090974000534 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1090974000535 tRNA binding surface [nucleotide binding]; other site 1090974000536 anticodon binding site; other site 1090974000537 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1090974000538 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1090974000539 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1090974000540 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1090974000541 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1090974000542 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974000543 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1090974000544 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1090974000545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974000546 motif II; other site 1090974000547 hypothetical protein; Reviewed; Region: PRK00024 1090974000548 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1090974000549 MPN+ (JAMM) motif; other site 1090974000550 Zinc-binding site [ion binding]; other site 1090974000551 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1090974000552 DNA-binding site [nucleotide binding]; DNA binding site 1090974000553 RNA-binding motif; other site 1090974000554 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1090974000555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1090974000556 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1090974000557 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1090974000558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974000559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974000561 Walker A/P-loop; other site 1090974000562 ATP binding site [chemical binding]; other site 1090974000563 Q-loop/lid; other site 1090974000564 ABC transporter signature motif; other site 1090974000565 Walker B; other site 1090974000566 D-loop; other site 1090974000567 H-loop/switch region; other site 1090974000568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974000569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974000570 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1090974000571 Walker A/P-loop; other site 1090974000572 ATP binding site [chemical binding]; other site 1090974000573 Q-loop/lid; other site 1090974000574 ABC transporter signature motif; other site 1090974000575 Walker B; other site 1090974000576 D-loop; other site 1090974000577 H-loop/switch region; other site 1090974000578 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1090974000579 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1090974000580 trimer interface [polypeptide binding]; other site 1090974000581 putative metal binding site [ion binding]; other site 1090974000582 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1090974000583 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1090974000584 active site 1090974000585 homodimer interface [polypeptide binding]; other site 1090974000586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1090974000587 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1090974000588 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1090974000589 catalytic residues [active] 1090974000590 catalytic nucleophile [active] 1090974000591 Presynaptic Site I dimer interface [polypeptide binding]; other site 1090974000592 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1090974000593 Synaptic Flat tetramer interface [polypeptide binding]; other site 1090974000594 Synaptic Site I dimer interface [polypeptide binding]; other site 1090974000595 DNA binding site [nucleotide binding] 1090974000596 potential frameshift: common BLAST hit: gi|125718905|ref|YP_001036038.1| cell wall surface anchor family protein 1090974000597 Cna protein B-type domain; Region: Cna_B; pfam05738 1090974000598 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000599 domain interaction interfaces [polypeptide binding]; other site 1090974000600 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000601 domain interaction interfaces [polypeptide binding]; other site 1090974000602 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000603 domain interaction interfaces [polypeptide binding]; other site 1090974000604 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000605 domain interaction interfaces [polypeptide binding]; other site 1090974000606 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000607 domain interaction interfaces [polypeptide binding]; other site 1090974000608 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000609 domain interaction interfaces [polypeptide binding]; other site 1090974000610 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000611 domain interaction interfaces [polypeptide binding]; other site 1090974000612 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000613 domain interaction interfaces [polypeptide binding]; other site 1090974000614 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000615 domain interaction interfaces [polypeptide binding]; other site 1090974000616 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000617 domain interaction interfaces [polypeptide binding]; other site 1090974000618 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000619 domain interaction interfaces [polypeptide binding]; other site 1090974000620 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000621 domain interaction interfaces [polypeptide binding]; other site 1090974000622 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000623 domain interaction interfaces [polypeptide binding]; other site 1090974000624 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000625 domain interaction interfaces [polypeptide binding]; other site 1090974000626 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000627 domain interaction interfaces [polypeptide binding]; other site 1090974000628 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000629 domain interaction interfaces [polypeptide binding]; other site 1090974000630 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000631 domain interaction interfaces [polypeptide binding]; other site 1090974000632 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000633 domain interaction interfaces [polypeptide binding]; other site 1090974000634 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000635 domain interaction interfaces [polypeptide binding]; other site 1090974000636 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974000637 domain interaction interfaces [polypeptide binding]; other site 1090974000638 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1090974000639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1090974000640 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1090974000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1090974000642 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1090974000643 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 1090974000644 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1090974000645 active site 1090974000646 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1090974000647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1090974000648 FeS/SAM binding site; other site 1090974000649 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1090974000650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974000651 DNA-binding site [nucleotide binding]; DNA binding site 1090974000652 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1090974000653 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1090974000654 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1090974000655 dimer interface [polypeptide binding]; other site 1090974000656 active site 1090974000657 glycine loop; other site 1090974000658 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1090974000659 active site 1090974000660 intersubunit interactions; other site 1090974000661 catalytic residue [active] 1090974000662 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1090974000663 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1090974000664 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 1090974000665 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1090974000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974000667 active site 1090974000668 phosphorylation site [posttranslational modification] 1090974000669 intermolecular recognition site; other site 1090974000670 dimerization interface [polypeptide binding]; other site 1090974000671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974000672 HAMP domain; Region: HAMP; pfam00672 1090974000673 dimerization interface [polypeptide binding]; other site 1090974000674 Histidine kinase; Region: His_kinase; pfam06580 1090974000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974000676 ATP binding site [chemical binding]; other site 1090974000677 Mg2+ binding site [ion binding]; other site 1090974000678 G-X-G motif; other site 1090974000679 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1090974000680 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1090974000681 putative ligand binding site [chemical binding]; other site 1090974000682 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1090974000683 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1090974000684 Walker A/P-loop; other site 1090974000685 ATP binding site [chemical binding]; other site 1090974000686 Q-loop/lid; other site 1090974000687 ABC transporter signature motif; other site 1090974000688 Walker B; other site 1090974000689 D-loop; other site 1090974000690 H-loop/switch region; other site 1090974000691 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1090974000692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1090974000693 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1090974000694 TM-ABC transporter signature motif; other site 1090974000695 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1090974000696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974000697 Walker A/P-loop; other site 1090974000698 ATP binding site [chemical binding]; other site 1090974000699 Q-loop/lid; other site 1090974000700 ABC transporter signature motif; other site 1090974000701 Walker B; other site 1090974000702 D-loop; other site 1090974000703 H-loop/switch region; other site 1090974000704 inner membrane transport permease; Provisional; Region: PRK15066 1090974000705 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1090974000706 GMP synthase; Reviewed; Region: guaA; PRK00074 1090974000707 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1090974000708 AMP/PPi binding site [chemical binding]; other site 1090974000709 candidate oxyanion hole; other site 1090974000710 catalytic triad [active] 1090974000711 potential glutamine specificity residues [chemical binding]; other site 1090974000712 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1090974000713 ATP Binding subdomain [chemical binding]; other site 1090974000714 Dimerization subdomain; other site 1090974000715 pantothenate kinase; Provisional; Region: PRK05439 1090974000716 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1090974000717 ATP-binding site [chemical binding]; other site 1090974000718 CoA-binding site [chemical binding]; other site 1090974000719 Mg2+-binding site [ion binding]; other site 1090974000720 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1090974000721 active site 1090974000722 catalytic triad [active] 1090974000723 oxyanion hole [active] 1090974000724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974000725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1090974000726 S-adenosylmethionine binding site [chemical binding]; other site 1090974000727 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1090974000728 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1090974000729 active site 1090974000730 catalytic motif [active] 1090974000731 Zn binding site [ion binding]; other site 1090974000732 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1090974000733 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1090974000734 ligand binding site [chemical binding]; other site 1090974000735 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1090974000736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1090974000737 Walker A/P-loop; other site 1090974000738 ATP binding site [chemical binding]; other site 1090974000739 Q-loop/lid; other site 1090974000740 ABC transporter signature motif; other site 1090974000741 Walker B; other site 1090974000742 D-loop; other site 1090974000743 H-loop/switch region; other site 1090974000744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1090974000745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1090974000746 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1090974000747 TM-ABC transporter signature motif; other site 1090974000748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1090974000749 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1090974000750 TM-ABC transporter signature motif; other site 1090974000751 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1090974000752 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1090974000753 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1090974000754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974000755 catalytic core [active] 1090974000756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974000757 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1090974000758 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1090974000759 active site 1090974000760 dimer interface [polypeptide binding]; other site 1090974000761 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1090974000762 S17 interaction site [polypeptide binding]; other site 1090974000763 S8 interaction site; other site 1090974000764 16S rRNA interaction site [nucleotide binding]; other site 1090974000765 streptomycin interaction site [chemical binding]; other site 1090974000766 23S rRNA interaction site [nucleotide binding]; other site 1090974000767 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1090974000768 30S ribosomal protein S7; Validated; Region: PRK05302 1090974000769 elongation factor G; Reviewed; Region: PRK00007 1090974000770 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1090974000771 G1 box; other site 1090974000772 putative GEF interaction site [polypeptide binding]; other site 1090974000773 GTP/Mg2+ binding site [chemical binding]; other site 1090974000774 Switch I region; other site 1090974000775 G2 box; other site 1090974000776 G3 box; other site 1090974000777 Switch II region; other site 1090974000778 G4 box; other site 1090974000779 G5 box; other site 1090974000780 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1090974000781 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1090974000782 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1090974000783 elongation factor Tu; Reviewed; Region: PRK00049 1090974000784 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1090974000785 G1 box; other site 1090974000786 GEF interaction site [polypeptide binding]; other site 1090974000787 GTP/Mg2+ binding site [chemical binding]; other site 1090974000788 Switch I region; other site 1090974000789 G2 box; other site 1090974000790 G3 box; other site 1090974000791 Switch II region; other site 1090974000792 G4 box; other site 1090974000793 G5 box; other site 1090974000794 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1090974000795 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1090974000796 Antibiotic Binding Site [chemical binding]; other site 1090974000797 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1090974000798 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1090974000799 catalytic site [active] 1090974000800 G-X2-G-X-G-K; other site 1090974000801 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1090974000802 proline racemase; Provisional; Region: PRK13969 1090974000803 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1090974000804 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1090974000805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974000806 ATP binding site [chemical binding]; other site 1090974000807 putative Mg++ binding site [ion binding]; other site 1090974000808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974000809 nucleotide binding region [chemical binding]; other site 1090974000810 ATP-binding site [chemical binding]; other site 1090974000811 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1090974000812 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1090974000813 putative active site [active] 1090974000814 substrate binding site [chemical binding]; other site 1090974000815 putative cosubstrate binding site; other site 1090974000816 catalytic site [active] 1090974000817 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1090974000818 substrate binding site [chemical binding]; other site 1090974000819 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1090974000820 NusB family; Region: NusB; pfam01029 1090974000821 putative RNA binding site [nucleotide binding]; other site 1090974000822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974000823 S-adenosylmethionine binding site [chemical binding]; other site 1090974000824 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1090974000825 active site 1090974000826 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1090974000827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1090974000828 active site 1090974000829 ATP binding site [chemical binding]; other site 1090974000830 substrate binding site [chemical binding]; other site 1090974000831 activation loop (A-loop); other site 1090974000832 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1090974000833 PASTA domain; Region: PASTA; smart00740 1090974000834 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1090974000835 ribosome small subunit-dependent GTPase A; Region: TIGR00157 1090974000836 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1090974000837 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1090974000838 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1090974000839 GTP/Mg2+ binding site [chemical binding]; other site 1090974000840 G4 box; other site 1090974000841 G5 box; other site 1090974000842 G1 box; other site 1090974000843 Switch I region; other site 1090974000844 G2 box; other site 1090974000845 G3 box; other site 1090974000846 Switch II region; other site 1090974000847 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1090974000848 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1090974000849 substrate binding site [chemical binding]; other site 1090974000850 hexamer interface [polypeptide binding]; other site 1090974000851 metal binding site [ion binding]; metal-binding site 1090974000852 Thiamine pyrophosphokinase; Region: TPK; cd07995 1090974000853 active site 1090974000854 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1090974000855 dimerization interface [polypeptide binding]; other site 1090974000856 thiamine binding site [chemical binding]; other site 1090974000857 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1090974000858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1090974000859 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1090974000860 DAK2 domain; Region: Dak2; pfam02734 1090974000861 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1090974000862 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1090974000863 generic binding surface II; other site 1090974000864 ssDNA binding site; other site 1090974000865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974000866 ATP binding site [chemical binding]; other site 1090974000867 putative Mg++ binding site [ion binding]; other site 1090974000868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974000869 nucleotide binding region [chemical binding]; other site 1090974000870 ATP-binding site [chemical binding]; other site 1090974000871 putative phosphate acyltransferase; Provisional; Region: PRK05331 1090974000872 acyl carrier protein; Provisional; Region: acpP; PRK00982 1090974000873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1090974000874 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1090974000875 substrate binding pocket [chemical binding]; other site 1090974000876 membrane-bound complex binding site; other site 1090974000877 hinge residues; other site 1090974000878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974000879 dimer interface [polypeptide binding]; other site 1090974000880 conserved gate region; other site 1090974000881 putative PBP binding loops; other site 1090974000882 ABC-ATPase subunit interface; other site 1090974000883 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1090974000884 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1090974000885 Walker A/P-loop; other site 1090974000886 ATP binding site [chemical binding]; other site 1090974000887 Q-loop/lid; other site 1090974000888 ABC transporter signature motif; other site 1090974000889 Walker B; other site 1090974000890 D-loop; other site 1090974000891 H-loop/switch region; other site 1090974000892 maltose O-acetyltransferase; Provisional; Region: PRK10092 1090974000893 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1090974000894 active site 1090974000895 substrate binding site [chemical binding]; other site 1090974000896 trimer interface [polypeptide binding]; other site 1090974000897 CoA binding site [chemical binding]; other site 1090974000898 hypothetical protein; Provisional; Region: PRK07248 1090974000899 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1090974000900 HTH domain; Region: HTH_11; pfam08279 1090974000901 3H domain; Region: 3H; pfam02829 1090974000902 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1090974000903 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1090974000904 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1090974000905 NAD binding site [chemical binding]; other site 1090974000906 dimer interface [polypeptide binding]; other site 1090974000907 substrate binding site [chemical binding]; other site 1090974000908 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1090974000909 putative active site [active] 1090974000910 catalytic residue [active] 1090974000911 GI:332685798; transcription-repair coupling factor 1090974000912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974000913 RNA binding surface [nucleotide binding]; other site 1090974000914 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1090974000915 Septum formation initiator; Region: DivIC; pfam04977 1090974000916 hypothetical protein; Provisional; Region: PRK08582 1090974000917 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1090974000918 RNA binding site [nucleotide binding]; other site 1090974000919 GI:332685802; tRNA(Ile)-lysidine synthetase 1090974000920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974000921 active site 1090974000922 FtsH Extracellular; Region: FtsH_ext; pfam06480 1090974000923 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1090974000924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974000925 Walker A motif; other site 1090974000926 ATP binding site [chemical binding]; other site 1090974000927 Walker B motif; other site 1090974000928 arginine finger; other site 1090974000929 Peptidase family M41; Region: Peptidase_M41; pfam01434 1090974000930 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1090974000931 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1090974000932 dimerization interface [polypeptide binding]; other site 1090974000933 domain crossover interface; other site 1090974000934 redox-dependent activation switch; other site 1090974000935 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1090974000936 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1090974000937 FMN binding site [chemical binding]; other site 1090974000938 active site 1090974000939 catalytic residues [active] 1090974000940 substrate binding site [chemical binding]; other site 1090974000941 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1090974000942 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1090974000943 dimer interface [polypeptide binding]; other site 1090974000944 putative anticodon binding site; other site 1090974000945 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1090974000946 motif 1; other site 1090974000947 active site 1090974000948 motif 2; other site 1090974000949 motif 3; other site 1090974000950 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1090974000951 beta-galactosidase; Region: BGL; TIGR03356 1090974000952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974000953 catalytic core [active] 1090974000954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974000955 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1090974000956 nucleoside/Zn binding site; other site 1090974000957 dimer interface [polypeptide binding]; other site 1090974000958 catalytic motif [active] 1090974000959 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1090974000960 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1090974000961 metal-binding site [ion binding] 1090974000962 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1090974000963 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1090974000964 metal-binding site [ion binding] 1090974000965 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974000966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974000967 motif II; other site 1090974000968 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1090974000969 metal-binding site [ion binding] 1090974000970 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1090974000971 trimer interface [polypeptide binding]; other site 1090974000972 active site 1090974000973 G bulge; other site 1090974000974 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1090974000975 active site 1090974000976 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1090974000977 active site 2 [active] 1090974000978 active site 1 [active] 1090974000979 Protein of unknown function DUF72; Region: DUF72; pfam01904 1090974000980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1090974000981 metal binding site [ion binding]; metal-binding site 1090974000982 trigger factor; Provisional; Region: tig; PRK01490 1090974000983 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1090974000984 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1090974000985 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1090974000986 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1090974000987 oligomer interface [polypeptide binding]; other site 1090974000988 active site 1090974000989 metal binding site [ion binding]; metal-binding site 1090974000990 Protein of unknown function (DUF975); Region: DUF975; cl10504 1090974000991 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1090974000992 putative hydrolase; Provisional; Region: PRK02113 1090974000993 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1090974000994 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1090974000995 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1090974000996 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1090974000997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974000998 S-adenosylmethionine binding site [chemical binding]; other site 1090974000999 peroxiredoxin; Region: AhpC; TIGR03137 1090974001000 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1090974001001 dimer interface [polypeptide binding]; other site 1090974001002 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1090974001003 catalytic triad [active] 1090974001004 peroxidatic and resolving cysteines [active] 1090974001005 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1090974001006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1090974001007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1090974001008 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1090974001009 catalytic residue [active] 1090974001010 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1090974001011 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1090974001012 active site 1090974001013 catalytic site [active] 1090974001014 substrate binding site [chemical binding]; other site 1090974001015 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1090974001016 active site 1090974001017 putative catalytic site [active] 1090974001018 DNA binding site [nucleotide binding] 1090974001019 putative phosphate binding site [ion binding]; other site 1090974001020 metal binding site A [ion binding]; metal-binding site 1090974001021 AP binding site [nucleotide binding]; other site 1090974001022 metal binding site B [ion binding]; metal-binding site 1090974001023 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1090974001024 FAD binding domain; Region: FAD_binding_4; pfam01565 1090974001025 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1090974001026 FOG: CBS domain [General function prediction only]; Region: COG0517 1090974001027 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1090974001028 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1090974001029 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1090974001030 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1090974001031 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1090974001032 putative homodimer interface [polypeptide binding]; other site 1090974001033 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1090974001034 heterodimer interface [polypeptide binding]; other site 1090974001035 homodimer interface [polypeptide binding]; other site 1090974001036 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1090974001037 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1090974001038 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1090974001039 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1090974001040 23S rRNA interface [nucleotide binding]; other site 1090974001041 L7/L12 interface [polypeptide binding]; other site 1090974001042 putative thiostrepton binding site; other site 1090974001043 L25 interface [polypeptide binding]; other site 1090974001044 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1090974001045 mRNA/rRNA interface [nucleotide binding]; other site 1090974001046 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1090974001047 23S rRNA interface [nucleotide binding]; other site 1090974001048 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1090974001049 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1090974001050 core dimer interface [polypeptide binding]; other site 1090974001051 peripheral dimer interface [polypeptide binding]; other site 1090974001052 L10 interface [polypeptide binding]; other site 1090974001053 L11 interface [polypeptide binding]; other site 1090974001054 putative EF-Tu interaction site [polypeptide binding]; other site 1090974001055 putative EF-G interaction site [polypeptide binding]; other site 1090974001056 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 1090974001057 active site 1090974001058 catalytic site [active] 1090974001059 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 1090974001060 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 1090974001061 Ca binding site [ion binding]; other site 1090974001062 substrate binding site [chemical binding]; other site 1090974001063 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1090974001064 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1090974001065 NAD binding site [chemical binding]; other site 1090974001066 substrate binding site [chemical binding]; other site 1090974001067 putative active site [active] 1090974001068 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1090974001069 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1090974001070 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1090974001071 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1090974001072 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1090974001073 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1090974001074 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1090974001075 RPB1 interaction site [polypeptide binding]; other site 1090974001076 RPB10 interaction site [polypeptide binding]; other site 1090974001077 RPB11 interaction site [polypeptide binding]; other site 1090974001078 RPB3 interaction site [polypeptide binding]; other site 1090974001079 RPB12 interaction site [polypeptide binding]; other site 1090974001080 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1090974001081 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1090974001082 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1090974001083 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1090974001084 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1090974001085 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1090974001086 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1090974001087 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1090974001088 DNA binding site [nucleotide binding] 1090974001089 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1090974001090 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1090974001091 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1090974001092 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1090974001093 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1090974001094 dimerization interface [polypeptide binding]; other site 1090974001095 DPS ferroxidase diiron center [ion binding]; other site 1090974001096 ion pore; other site 1090974001097 TRAM domain; Region: TRAM; pfam01938 1090974001098 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1090974001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974001100 S-adenosylmethionine binding site [chemical binding]; other site 1090974001101 RecX family; Region: RecX; cl00936 1090974001102 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1090974001103 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1090974001104 minor groove reading motif; other site 1090974001105 helix-hairpin-helix signature motif; other site 1090974001106 substrate binding pocket [chemical binding]; other site 1090974001107 active site 1090974001108 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1090974001109 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1090974001110 DNA binding and oxoG recognition site [nucleotide binding] 1090974001111 hypothetical protein; Provisional; Region: PRK13662 1090974001112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974001113 Coenzyme A binding pocket [chemical binding]; other site 1090974001114 GI:332687198; hypothetical protein 1090974001115 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1090974001116 Domain of unknown function DUF21; Region: DUF21; pfam01595 1090974001117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1090974001118 Transporter associated domain; Region: CorC_HlyC; pfam03471 1090974001119 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1090974001120 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1090974001121 G1 box; other site 1090974001122 putative GEF interaction site [polypeptide binding]; other site 1090974001123 GTP/Mg2+ binding site [chemical binding]; other site 1090974001124 Switch I region; other site 1090974001125 G2 box; other site 1090974001126 G3 box; other site 1090974001127 Switch II region; other site 1090974001128 G4 box; other site 1090974001129 G5 box; other site 1090974001130 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1090974001131 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1090974001132 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1090974001133 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1090974001134 active site 1090974001135 metal binding site [ion binding]; metal-binding site 1090974001136 DNA binding site [nucleotide binding] 1090974001137 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1090974001138 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1090974001139 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1090974001140 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1090974001141 generic binding surface II; other site 1090974001142 generic binding surface I; other site 1090974001143 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1090974001144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974001145 Zn2+ binding site [ion binding]; other site 1090974001146 Mg2+ binding site [ion binding]; other site 1090974001147 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1090974001148 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1090974001149 YtxH-like protein; Region: YtxH; pfam12732 1090974001150 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1090974001151 HIT family signature motif; other site 1090974001152 catalytic residue [active] 1090974001153 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1090974001154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1090974001155 Walker A/P-loop; other site 1090974001156 ATP binding site [chemical binding]; other site 1090974001157 Q-loop/lid; other site 1090974001158 ABC transporter signature motif; other site 1090974001159 Walker B; other site 1090974001160 D-loop; other site 1090974001161 H-loop/switch region; other site 1090974001162 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1090974001163 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1090974001164 Phosphotransferase enzyme family; Region: APH; pfam01636 1090974001165 active site 1090974001166 substrate binding site [chemical binding]; other site 1090974001167 ATP binding site [chemical binding]; other site 1090974001168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974001169 S-adenosylmethionine binding site [chemical binding]; other site 1090974001170 oxidoreductase; Provisional; Region: PRK07985 1090974001171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974001172 NAD(P) binding site [chemical binding]; other site 1090974001173 active site 1090974001174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1090974001175 conserved hypothetical protein; Region: TIGR02328 1090974001176 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1090974001177 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1090974001178 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1090974001179 active site 1090974001180 Zn binding site [ion binding]; other site 1090974001181 GI:332687180; pectate lyase 1090974001182 Predicted integral membrane protein [Function unknown]; Region: COG5652 1090974001183 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001184 hypothetical protein; Validated; Region: PRK00110 1090974001185 GI:332687176; oligopeptide ABC transporter periplasmic oligopeptide-binding protein OppA 1090974001186 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1090974001187 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1090974001188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974001189 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1090974001190 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1090974001191 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1090974001192 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1090974001193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974001194 RNA binding surface [nucleotide binding]; other site 1090974001195 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1090974001196 active site 1090974001197 uracil binding [chemical binding]; other site 1090974001198 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1090974001199 putative substrate binding site [chemical binding]; other site 1090974001200 putative ATP binding site [chemical binding]; other site 1090974001201 dipeptidase PepV; Reviewed; Region: PRK07318 1090974001202 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1090974001203 active site 1090974001204 metal binding site [ion binding]; metal-binding site 1090974001205 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1090974001206 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1090974001207 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1090974001208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1090974001209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974001210 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1090974001211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974001212 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1090974001213 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1090974001214 Metal-binding active site; metal-binding site 1090974001215 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1090974001216 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1090974001217 Bacterial transcriptional regulator; Region: IclR; pfam01614 1090974001218 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1090974001219 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1090974001220 active site 1090974001221 intersubunit interface [polypeptide binding]; other site 1090974001222 catalytic residue [active] 1090974001223 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1090974001224 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1090974001225 substrate binding site [chemical binding]; other site 1090974001226 ATP binding site [chemical binding]; other site 1090974001227 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1090974001228 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 1090974001229 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1090974001230 NADP binding site [chemical binding]; other site 1090974001231 homodimer interface [polypeptide binding]; other site 1090974001232 active site 1090974001233 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1090974001234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1090974001235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974001236 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1090974001237 N- and C-terminal domain interface [polypeptide binding]; other site 1090974001238 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1090974001239 active site 1090974001240 putative catalytic site [active] 1090974001241 metal binding site [ion binding]; metal-binding site 1090974001242 ATP binding site [chemical binding]; other site 1090974001243 carbohydrate binding site [chemical binding]; other site 1090974001244 L-rhamnose isomerase; Provisional; Region: PRK01076 1090974001245 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1090974001246 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1090974001247 intersubunit interface [polypeptide binding]; other site 1090974001248 active site 1090974001249 Zn2+ binding site [ion binding]; other site 1090974001250 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1090974001251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974001252 putative substrate translocation pore; other site 1090974001253 POT family; Region: PTR2; cl17359 1090974001254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001255 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1090974001256 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1090974001257 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1090974001258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1090974001259 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1090974001260 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1090974001261 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1090974001262 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1090974001263 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1090974001264 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1090974001265 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1090974001266 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 1090974001267 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1090974001268 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1090974001269 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1090974001270 Walker A/P-loop; other site 1090974001271 ATP binding site [chemical binding]; other site 1090974001272 Q-loop/lid; other site 1090974001273 ABC transporter signature motif; other site 1090974001274 Walker B; other site 1090974001275 D-loop; other site 1090974001276 H-loop/switch region; other site 1090974001277 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1090974001278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001279 dimer interface [polypeptide binding]; other site 1090974001280 conserved gate region; other site 1090974001281 putative PBP binding loops; other site 1090974001282 ABC-ATPase subunit interface; other site 1090974001283 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1090974001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001285 dimer interface [polypeptide binding]; other site 1090974001286 conserved gate region; other site 1090974001287 putative PBP binding loops; other site 1090974001288 ABC-ATPase subunit interface; other site 1090974001289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1090974001290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1090974001291 active site 1090974001292 metal binding site [ion binding]; metal-binding site 1090974001293 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1090974001294 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1090974001295 active site 1090974001296 metal binding site [ion binding]; metal-binding site 1090974001297 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1090974001298 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1090974001299 S-adenosylmethionine synthetase 1090974001300 GI:332687129; hypothetical protein 1090974001301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1090974001302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1090974001303 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1090974001304 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1090974001305 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1090974001306 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1090974001307 active site 1090974001308 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1090974001309 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001311 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001312 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974001313 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1090974001314 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1090974001315 HIGH motif; other site 1090974001316 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1090974001317 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1090974001318 active site 1090974001319 KMSKS motif; other site 1090974001320 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1090974001321 tRNA binding surface [nucleotide binding]; other site 1090974001322 GI:332687122; amino acid ABC transporter amino acid-binding protein 1090974001323 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974001324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974001325 Walker A/P-loop; other site 1090974001326 ATP binding site [chemical binding]; other site 1090974001327 Q-loop/lid; other site 1090974001328 ABC transporter signature motif; other site 1090974001329 Walker B; other site 1090974001330 D-loop; other site 1090974001331 H-loop/switch region; other site 1090974001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001333 dimer interface [polypeptide binding]; other site 1090974001334 conserved gate region; other site 1090974001335 putative PBP binding loops; other site 1090974001336 ABC-ATPase subunit interface; other site 1090974001337 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1090974001338 Asp23 family; Region: Asp23; pfam03780 1090974001339 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1090974001340 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1090974001341 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1090974001342 5S rRNA interface [nucleotide binding]; other site 1090974001343 CTC domain interface [polypeptide binding]; other site 1090974001344 L16 interface [polypeptide binding]; other site 1090974001345 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1090974001346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974001347 motif II; other site 1090974001348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974001349 Coenzyme A binding pocket [chemical binding]; other site 1090974001350 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1090974001351 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1090974001352 Sugar specificity; other site 1090974001353 Pyrimidine base specificity; other site 1090974001354 ATP-binding site [chemical binding]; other site 1090974001355 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1090974001356 ATP binding site [chemical binding]; other site 1090974001357 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1090974001358 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1090974001359 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1090974001360 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1090974001361 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1090974001362 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1090974001363 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974001364 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1090974001365 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1090974001366 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1090974001367 ATP binding site [chemical binding]; other site 1090974001368 Mg++ binding site [ion binding]; other site 1090974001369 motif III; other site 1090974001370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974001371 nucleotide binding region [chemical binding]; other site 1090974001372 ATP-binding site [chemical binding]; other site 1090974001373 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1090974001374 GI:332687104; alanine racemase 1090974001375 PemK-like protein; Region: PemK; pfam02452 1090974001376 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1090974001377 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1090974001378 substrate binding pocket [chemical binding]; other site 1090974001379 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1090974001380 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1090974001381 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1090974001382 potential frameshift: common BLAST hit: gi|15673652|ref|NP_267826.1| phage infection protein 1090974001383 Predicted membrane protein [Function unknown]; Region: COG1511 1090974001384 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1090974001385 potential frameshift: common BLAST hit: gi|332687097|ref|YP_004456871.1| phage infection protein 1090974001386 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1090974001387 FlgN protein; Region: FlgN; cl09176 1090974001388 Predicted membrane protein [Function unknown]; Region: COG1511 1090974001389 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1090974001390 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1090974001391 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1090974001392 Amino acid permease; Region: AA_permease_2; pfam13520 1090974001393 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1090974001394 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1090974001395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1090974001396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974001397 salt bridge; other site 1090974001398 non-specific DNA binding site [nucleotide binding]; other site 1090974001399 sequence-specific DNA binding site [nucleotide binding]; other site 1090974001400 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1090974001401 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1090974001402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974001403 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1090974001404 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1090974001405 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1090974001406 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1090974001407 Domain of unknown function DUF21; Region: DUF21; pfam01595 1090974001408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1090974001409 Transporter associated domain; Region: CorC_HlyC; smart01091 1090974001410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1090974001411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974001412 non-specific DNA binding site [nucleotide binding]; other site 1090974001413 salt bridge; other site 1090974001414 sequence-specific DNA binding site [nucleotide binding]; other site 1090974001415 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1090974001416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974001417 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1090974001418 Mga helix-turn-helix domain; Region: Mga; pfam05043 1090974001419 DNA polymerase I; Provisional; Region: PRK05755 1090974001420 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1090974001421 active site 1090974001422 metal binding site 1 [ion binding]; metal-binding site 1090974001423 putative 5' ssDNA interaction site; other site 1090974001424 metal binding site 3; metal-binding site 1090974001425 metal binding site 2 [ion binding]; metal-binding site 1090974001426 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1090974001427 putative DNA binding site [nucleotide binding]; other site 1090974001428 putative metal binding site [ion binding]; other site 1090974001429 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1090974001430 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1090974001431 active site 1090974001432 DNA binding site [nucleotide binding] 1090974001433 catalytic site [active] 1090974001434 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1090974001435 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1090974001436 DNA binding site [nucleotide binding] 1090974001437 catalytic residue [active] 1090974001438 H2TH interface [polypeptide binding]; other site 1090974001439 putative catalytic residues [active] 1090974001440 turnover-facilitating residue; other site 1090974001441 intercalation triad [nucleotide binding]; other site 1090974001442 8OG recognition residue [nucleotide binding]; other site 1090974001443 putative reading head residues; other site 1090974001444 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1090974001445 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1090974001446 GI:332687080; dephospho-CoA kinase 1090974001447 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1090974001448 ATP cone domain; Region: ATP-cone; pfam03477 1090974001449 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1090974001450 primosomal protein DnaI; Reviewed; Region: PRK08939 1090974001451 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1090974001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974001453 Walker A motif; other site 1090974001454 ATP binding site [chemical binding]; other site 1090974001455 Walker B motif; other site 1090974001456 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1090974001457 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1090974001458 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1090974001459 DXD motif; other site 1090974001460 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1090974001461 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1090974001462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974001463 catalytic core [active] 1090974001464 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1090974001465 AAA domain; Region: AAA_30; pfam13604 1090974001466 Family description; Region: UvrD_C_2; pfam13538 1090974001467 ECF transporter substrate-specific protein QueT; GI:332687067 1090974001468 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1090974001469 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1090974001470 dimer interface [polypeptide binding]; other site 1090974001471 PYR/PP interface [polypeptide binding]; other site 1090974001472 TPP binding site [chemical binding]; other site 1090974001473 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1090974001474 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1090974001475 TPP-binding site [chemical binding]; other site 1090974001476 dimer interface [polypeptide binding]; other site 1090974001477 FemAB family; Region: FemAB; pfam02388 1090974001478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1090974001479 Predicted membrane protein [Function unknown]; Region: COG4684 1090974001480 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1090974001481 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1090974001482 Flavoprotein; Region: Flavoprotein; pfam02441 1090974001483 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1090974001484 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1090974001485 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1090974001486 NADP binding site [chemical binding]; other site 1090974001487 dimer interface [polypeptide binding]; other site 1090974001488 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1090974001489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974001490 non-specific DNA binding site [nucleotide binding]; other site 1090974001491 salt bridge; other site 1090974001492 sequence-specific DNA binding site [nucleotide binding]; other site 1090974001493 Cupin domain; Region: Cupin_2; pfam07883 1090974001494 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1090974001495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974001496 Walker A/P-loop; other site 1090974001497 ATP binding site [chemical binding]; other site 1090974001498 Q-loop/lid; other site 1090974001499 ABC transporter signature motif; other site 1090974001500 Walker B; other site 1090974001501 D-loop; other site 1090974001502 H-loop/switch region; other site 1090974001503 TOBE domain; Region: TOBE_2; pfam08402 1090974001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001505 dimer interface [polypeptide binding]; other site 1090974001506 conserved gate region; other site 1090974001507 putative PBP binding loops; other site 1090974001508 ABC-ATPase subunit interface; other site 1090974001509 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1090974001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001511 putative PBP binding loops; other site 1090974001512 dimer interface [polypeptide binding]; other site 1090974001513 ABC-ATPase subunit interface; other site 1090974001514 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1090974001515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1090974001516 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1090974001517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001518 dimer interface [polypeptide binding]; other site 1090974001519 conserved gate region; other site 1090974001520 putative PBP binding loops; other site 1090974001521 ABC-ATPase subunit interface; other site 1090974001522 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1090974001523 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1090974001524 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1090974001525 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1090974001526 Walker A/P-loop; other site 1090974001527 ATP binding site [chemical binding]; other site 1090974001528 Q-loop/lid; other site 1090974001529 ABC transporter signature motif; other site 1090974001530 Walker B; other site 1090974001531 D-loop; other site 1090974001532 H-loop/switch region; other site 1090974001533 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1090974001534 Predicted transcriptional regulators [Transcription]; Region: COG1725 1090974001535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974001536 DNA-binding site [nucleotide binding]; DNA binding site 1090974001537 TrkA-C domain; Region: TrkA_C; pfam02080 1090974001538 ABC transporter ATP-binding protein Uup; GI:332687050 1090974001539 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1090974001540 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1090974001541 CoA binding domain; Region: CoA_binding; pfam02629 1090974001542 GI:332687048; abortive infection protein 1090974001543 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1090974001544 oligomerisation interface [polypeptide binding]; other site 1090974001545 mobile loop; other site 1090974001546 roof hairpin; other site 1090974001547 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1090974001548 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1090974001549 ring oligomerisation interface [polypeptide binding]; other site 1090974001550 ATP/Mg binding site [chemical binding]; other site 1090974001551 stacking interactions; other site 1090974001552 hinge regions; other site 1090974001553 Predicted membrane protein [Function unknown]; Region: COG2246 1090974001554 GtrA-like protein; Region: GtrA; pfam04138 1090974001555 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1090974001556 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1090974001557 active site 1090974001558 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1090974001559 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1090974001560 homodimer interface [polypeptide binding]; other site 1090974001561 NAD binding pocket [chemical binding]; other site 1090974001562 ATP binding pocket [chemical binding]; other site 1090974001563 Mg binding site [ion binding]; other site 1090974001564 active-site loop [active] 1090974001565 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1090974001566 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974001567 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1090974001568 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1090974001569 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1090974001570 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1090974001571 Esterase/lipase [General function prediction only]; Region: COG1647 1090974001572 ribonuclease R; Region: RNase_R; TIGR02063 1090974001573 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1090974001574 RNB domain; Region: RNB; pfam00773 1090974001575 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1090974001576 RNA binding site [nucleotide binding]; other site 1090974001577 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1090974001578 SmpB-tmRNA interface; other site 1090974001579 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1090974001580 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1090974001581 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 1090974001582 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1090974001583 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1090974001584 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1090974001585 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1090974001586 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1090974001587 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1090974001588 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1090974001589 beta subunit interaction interface [polypeptide binding]; other site 1090974001590 Walker A motif; other site 1090974001591 ATP binding site [chemical binding]; other site 1090974001592 Walker B motif; other site 1090974001593 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1090974001594 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1090974001595 core domain interface [polypeptide binding]; other site 1090974001596 delta subunit interface [polypeptide binding]; other site 1090974001597 epsilon subunit interface [polypeptide binding]; other site 1090974001598 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1090974001599 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1090974001600 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1090974001601 alpha subunit interaction interface [polypeptide binding]; other site 1090974001602 Walker A motif; other site 1090974001603 ATP binding site [chemical binding]; other site 1090974001604 Walker B motif; other site 1090974001605 inhibitor binding site; inhibition site 1090974001606 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1090974001607 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1090974001608 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1090974001609 gamma subunit interface [polypeptide binding]; other site 1090974001610 epsilon subunit interface [polypeptide binding]; other site 1090974001611 LBP interface [polypeptide binding]; other site 1090974001612 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1090974001613 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1090974001614 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1090974001615 hinge; other site 1090974001616 active site 1090974001617 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1090974001618 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1090974001619 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1090974001620 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1090974001621 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1090974001622 active site turn [active] 1090974001623 phosphorylation site [posttranslational modification] 1090974001624 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1090974001625 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1090974001626 HPr interaction site; other site 1090974001627 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1090974001628 active site 1090974001629 phosphorylation site [posttranslational modification] 1090974001630 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1090974001631 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1090974001632 active site 1090974001633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974001634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974001635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974001636 Walker A/P-loop; other site 1090974001637 ATP binding site [chemical binding]; other site 1090974001638 Q-loop/lid; other site 1090974001639 ABC transporter signature motif; other site 1090974001640 Walker B; other site 1090974001641 D-loop; other site 1090974001642 H-loop/switch region; other site 1090974001643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974001644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974001645 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1090974001646 Walker A/P-loop; other site 1090974001647 ATP binding site [chemical binding]; other site 1090974001648 Q-loop/lid; other site 1090974001649 ABC transporter signature motif; other site 1090974001650 Walker B; other site 1090974001651 D-loop; other site 1090974001652 H-loop/switch region; other site 1090974001653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1090974001654 active site 1090974001655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1090974001656 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1090974001657 Beta-lactamase; Region: Beta-lactamase; pfam00144 1090974001658 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1090974001659 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1090974001660 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1090974001661 catalytic triad [active] 1090974001662 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1090974001663 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974001664 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1090974001665 thymidine kinase; Provisional; Region: PRK04296 1090974001666 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1090974001667 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1090974001668 RF-1 domain; Region: RF-1; pfam00472 1090974001669 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1090974001670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974001671 S-adenosylmethionine binding site [chemical binding]; other site 1090974001672 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1090974001673 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1090974001674 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1090974001675 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1090974001676 dimer interface [polypeptide binding]; other site 1090974001677 active site 1090974001678 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1090974001679 folate binding site [chemical binding]; other site 1090974001680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974001681 active site 1090974001682 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1090974001683 ArsC family; Region: ArsC; pfam03960 1090974001684 putative ArsC-like catalytic residues; other site 1090974001685 putative TRX-like catalytic residues [active] 1090974001686 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1090974001687 lipoyl attachment site [posttranslational modification]; other site 1090974001688 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1090974001689 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1090974001690 Walker A/P-loop; other site 1090974001691 ATP binding site [chemical binding]; other site 1090974001692 Q-loop/lid; other site 1090974001693 ABC transporter signature motif; other site 1090974001694 Walker B; other site 1090974001695 D-loop; other site 1090974001696 H-loop/switch region; other site 1090974001697 NIL domain; Region: NIL; pfam09383 1090974001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974001699 dimer interface [polypeptide binding]; other site 1090974001700 conserved gate region; other site 1090974001701 ABC-ATPase subunit interface; other site 1090974001702 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1090974001703 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1090974001704 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1090974001705 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1090974001706 Walker A/P-loop; other site 1090974001707 ATP binding site [chemical binding]; other site 1090974001708 Q-loop/lid; other site 1090974001709 ABC transporter signature motif; other site 1090974001710 Walker B; other site 1090974001711 D-loop; other site 1090974001712 H-loop/switch region; other site 1090974001713 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1090974001714 FeS assembly protein SufD; Region: sufD; TIGR01981 1090974001715 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1090974001716 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1090974001717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974001718 catalytic residue [active] 1090974001719 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1090974001720 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1090974001721 trimerization site [polypeptide binding]; other site 1090974001722 active site 1090974001723 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1090974001724 FeS assembly protein SufB; Region: sufB; TIGR01980 1090974001725 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1090974001726 Man1-Src1p-C-terminal domain; Region: MSC; pfam09402 1090974001727 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1090974001728 nudix motif; other site 1090974001729 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1090974001730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974001731 motif II; other site 1090974001732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1090974001733 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1090974001734 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1090974001735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974001736 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1090974001737 active site 1090974001738 motif I; other site 1090974001739 motif II; other site 1090974001740 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1090974001741 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1090974001742 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1090974001743 siderophore binding site; other site 1090974001744 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1090974001745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974001746 dimer interface [polypeptide binding]; other site 1090974001747 ABC-ATPase subunit interface; other site 1090974001748 putative PBP binding regions; other site 1090974001749 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1090974001750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974001751 ABC-ATPase subunit interface; other site 1090974001752 dimer interface [polypeptide binding]; other site 1090974001753 putative PBP binding regions; other site 1090974001754 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1090974001755 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1090974001756 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1090974001757 Walker A/P-loop; other site 1090974001758 ATP binding site [chemical binding]; other site 1090974001759 Q-loop/lid; other site 1090974001760 ABC transporter signature motif; other site 1090974001761 Walker B; other site 1090974001762 D-loop; other site 1090974001763 H-loop/switch region; other site 1090974001764 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1090974001765 homotrimer interaction site [polypeptide binding]; other site 1090974001766 putative active site [active] 1090974001767 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1090974001768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974001769 non-specific DNA binding site [nucleotide binding]; other site 1090974001770 salt bridge; other site 1090974001771 sequence-specific DNA binding site [nucleotide binding]; other site 1090974001772 Predicted transcriptional regulator [Transcription]; Region: COG2932 1090974001773 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1090974001774 Catalytic site [active] 1090974001775 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1090974001776 DNA-binding interface [nucleotide binding]; DNA binding site 1090974001777 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 1090974001778 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1090974001779 Right handed beta helix region; Region: Beta_helix; pfam13229 1090974001780 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1090974001781 Phage protein; Region: DUF3647; pfam12363 1090974001782 Phage-related protein [Function unknown]; Region: COG5412 1090974001783 Phage tail protein; Region: Sipho_tail; cl17486 1090974001784 Phage-related protein [Function unknown]; Region: COG4722 1090974001785 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1090974001786 Phage-related protein [Function unknown]; Region: PblB; COG4926 1090974001787 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1090974001788 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1090974001789 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1090974001790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1090974001791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974001792 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974001793 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1090974001794 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1090974001795 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1090974001796 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1090974001797 mannonate dehydratase; Provisional; Region: PRK03906 1090974001798 mannonate dehydratase; Region: uxuA; TIGR00695 1090974001799 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974001800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974001801 putative substrate translocation pore; other site 1090974001802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1090974001803 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1090974001804 GTP-binding protein LepA; Provisional; Region: PRK05433 1090974001805 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1090974001806 G1 box; other site 1090974001807 putative GEF interaction site [polypeptide binding]; other site 1090974001808 GTP/Mg2+ binding site [chemical binding]; other site 1090974001809 Switch I region; other site 1090974001810 G2 box; other site 1090974001811 G3 box; other site 1090974001812 Switch II region; other site 1090974001813 G4 box; other site 1090974001814 G5 box; other site 1090974001815 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1090974001816 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1090974001817 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1090974001818 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1090974001819 GI:332686922; manganese ABC transporter ATP-binding protein SitB 1090974001820 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1090974001821 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974001822 ABC-ATPase subunit interface; other site 1090974001823 dimer interface [polypeptide binding]; other site 1090974001824 putative PBP binding regions; other site 1090974001825 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1090974001826 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1090974001827 metal binding site [ion binding]; metal-binding site 1090974001828 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1090974001829 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1090974001830 Walker A motif; other site 1090974001831 ATP binding site [chemical binding]; other site 1090974001832 Walker B motif; other site 1090974001833 GI:332686917; late competence protein ComGB, access of DNA to ComEA 1090974001834 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1090974001835 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1090974001836 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1090974001837 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1090974001838 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1090974001839 propionate/acetate kinase; Provisional; Region: PRK12379 1090974001840 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1090974001841 Ligand Binding Site [chemical binding]; other site 1090974001842 recombination factor protein RarA; Reviewed; Region: PRK13342 1090974001843 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1090974001844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974001845 Walker A motif; other site 1090974001846 ATP binding site [chemical binding]; other site 1090974001847 Walker B motif; other site 1090974001848 arginine finger; other site 1090974001849 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1090974001850 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1090974001851 active site 1090974001852 DNA binding site [nucleotide binding] 1090974001853 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1090974001854 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1090974001855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974001856 S-adenosylmethionine binding site [chemical binding]; other site 1090974001857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1090974001858 RNA methyltransferase, RsmE family; Region: TIGR00046 1090974001859 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1090974001860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974001861 Zn2+ binding site [ion binding]; other site 1090974001862 Mg2+ binding site [ion binding]; other site 1090974001863 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1090974001864 synthetase active site [active] 1090974001865 NTP binding site [chemical binding]; other site 1090974001866 metal binding site [ion binding]; metal-binding site 1090974001867 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1090974001868 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1090974001869 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1090974001870 putative active site [active] 1090974001871 dimerization interface [polypeptide binding]; other site 1090974001872 putative tRNAtyr binding site [nucleotide binding]; other site 1090974001873 potential frameshift: common BLAST hit: gi|332686840|ref|YP_004456614.1| aldo/keto reductase 1090974001874 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1090974001875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1090974001876 active site 1090974001877 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1090974001878 catalytic tetrad [active] 1090974001879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974001880 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974001881 Walker A/P-loop; other site 1090974001882 ATP binding site [chemical binding]; other site 1090974001883 Q-loop/lid; other site 1090974001884 ABC transporter signature motif; other site 1090974001885 Walker B; other site 1090974001886 D-loop; other site 1090974001887 H-loop/switch region; other site 1090974001888 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1090974001889 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1090974001890 FtsX-like permease family; Region: FtsX; pfam02687 1090974001891 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1090974001892 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1090974001893 dimer interface [polypeptide binding]; other site 1090974001894 motif 1; other site 1090974001895 active site 1090974001896 motif 2; other site 1090974001897 motif 3; other site 1090974001898 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1090974001899 anticodon binding site; other site 1090974001900 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1090974001901 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1090974001902 dimer interface [polypeptide binding]; other site 1090974001903 anticodon binding site; other site 1090974001904 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1090974001905 homodimer interface [polypeptide binding]; other site 1090974001906 motif 1; other site 1090974001907 active site 1090974001908 motif 2; other site 1090974001909 GAD domain; Region: GAD; pfam02938 1090974001910 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1090974001911 active site 1090974001912 motif 3; other site 1090974001913 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1090974001914 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1090974001915 ligand binding site; other site 1090974001916 oligomer interface; other site 1090974001917 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1090974001918 dimer interface [polypeptide binding]; other site 1090974001919 N-terminal domain interface [polypeptide binding]; other site 1090974001920 sulfate 1 binding site; other site 1090974001921 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1090974001922 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1090974001923 oligomer interface; other site 1090974001924 ligand binding site; other site 1090974001925 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1090974001926 dimer interface [polypeptide binding]; other site 1090974001927 N-terminal domain interface [polypeptide binding]; other site 1090974001928 sulfate 1 binding site; other site 1090974001929 glycogen synthase; Provisional; Region: glgA; PRK00654 1090974001930 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1090974001931 ADP-binding pocket [chemical binding]; other site 1090974001932 homodimer interface [polypeptide binding]; other site 1090974001933 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1090974001934 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1090974001935 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1090974001936 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1090974001937 GI:332686831; hypothetical protein 1090974001938 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1090974001939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974001940 active site 1090974001941 xanthine permease; Region: pbuX; TIGR03173 1090974001942 AIR carboxylase; Region: AIRC; pfam00731 1090974001943 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1090974001944 ATP-grasp domain; Region: ATP-grasp; pfam02222 1090974001945 adenylosuccinate lyase; Provisional; Region: PRK07492 1090974001946 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1090974001947 tetramer interface [polypeptide binding]; other site 1090974001948 active site 1090974001949 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1090974001950 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1090974001951 ATP binding site [chemical binding]; other site 1090974001952 active site 1090974001953 substrate binding site [chemical binding]; other site 1090974001954 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1090974001955 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1090974001956 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1090974001957 putative active site [active] 1090974001958 catalytic triad [active] 1090974001959 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1090974001960 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1090974001961 dimerization interface [polypeptide binding]; other site 1090974001962 ATP binding site [chemical binding]; other site 1090974001963 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1090974001964 dimerization interface [polypeptide binding]; other site 1090974001965 ATP binding site [chemical binding]; other site 1090974001966 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1090974001967 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1090974001968 active site 1090974001969 tetramer interface [polypeptide binding]; other site 1090974001970 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974001971 active site 1090974001972 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1090974001973 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1090974001974 dimerization interface [polypeptide binding]; other site 1090974001975 putative ATP binding site [chemical binding]; other site 1090974001976 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1090974001977 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1090974001978 active site 1090974001979 substrate binding site [chemical binding]; other site 1090974001980 cosubstrate binding site; other site 1090974001981 catalytic site [active] 1090974001982 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1090974001983 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1090974001984 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1090974001985 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1090974001986 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1090974001987 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1090974001988 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1090974001989 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1090974001990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974001991 putative substrate translocation pore; other site 1090974001992 drug efflux system protein MdtG; Provisional; Region: PRK09874 1090974001993 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1090974001994 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1090974001995 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1090974001996 active site 1090974001997 PHP Thumb interface [polypeptide binding]; other site 1090974001998 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1090974001999 generic binding surface I; other site 1090974002000 generic binding surface II; other site 1090974002001 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1090974002002 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1090974002003 active site 1090974002004 ADP/pyrophosphate binding site [chemical binding]; other site 1090974002005 dimerization interface [polypeptide binding]; other site 1090974002006 allosteric effector site; other site 1090974002007 fructose-1,6-bisphosphate binding site; other site 1090974002008 GI:332686805; pyruvate kinase 1090974002009 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1090974002010 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1090974002011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1090974002012 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1090974002013 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1090974002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974002016 active site 1090974002017 phosphorylation site [posttranslational modification] 1090974002018 intermolecular recognition site; other site 1090974002019 dimerization interface [polypeptide binding]; other site 1090974002020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974002021 DNA binding site [nucleotide binding] 1090974002022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1090974002023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974002024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974002025 dimer interface [polypeptide binding]; other site 1090974002026 phosphorylation site [posttranslational modification] 1090974002027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974002028 ATP binding site [chemical binding]; other site 1090974002029 Mg2+ binding site [ion binding]; other site 1090974002030 G-X-G motif; other site 1090974002031 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1090974002032 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1090974002033 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1090974002034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974002035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974002036 Walker A/P-loop; other site 1090974002037 ATP binding site [chemical binding]; other site 1090974002038 Q-loop/lid; other site 1090974002039 ABC transporter signature motif; other site 1090974002040 Walker B; other site 1090974002041 D-loop; other site 1090974002042 H-loop/switch region; other site 1090974002043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1090974002044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974002045 non-specific DNA binding site [nucleotide binding]; other site 1090974002046 salt bridge; other site 1090974002047 sequence-specific DNA binding site [nucleotide binding]; other site 1090974002048 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1090974002049 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974002050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974002051 active site 1090974002052 phosphorylation site [posttranslational modification] 1090974002053 intermolecular recognition site; other site 1090974002054 dimerization interface [polypeptide binding]; other site 1090974002055 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974002056 DNA binding site [nucleotide binding] 1090974002057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1090974002058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1090974002059 dimerization interface [polypeptide binding]; other site 1090974002060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1090974002061 putative active site [active] 1090974002062 heme pocket [chemical binding]; other site 1090974002063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974002064 dimer interface [polypeptide binding]; other site 1090974002065 phosphorylation site [posttranslational modification] 1090974002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974002067 ATP binding site [chemical binding]; other site 1090974002068 Mg2+ binding site [ion binding]; other site 1090974002069 G-X-G motif; other site 1090974002070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1090974002071 YycH protein; Region: YycH; pfam07435 1090974002072 YycH protein; Region: YycI; pfam09648 1090974002073 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1090974002074 Predicted permeases [General function prediction only]; Region: COG0701 1090974002075 Predicted membrane protein [Function unknown]; Region: COG3689 1090974002076 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1090974002077 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1090974002078 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1090974002079 hypothetical protein; Provisional; Region: PRK05473 1090974002080 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1090974002081 hypothetical protein; Provisional; Region: PRK13678 1090974002082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974002083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1090974002084 DNA binding site [nucleotide binding] 1090974002085 domain linker motif; other site 1090974002086 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1090974002087 ligand binding site [chemical binding]; other site 1090974002088 dimerization interface [polypeptide binding]; other site 1090974002089 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1090974002090 active site 1090974002091 P-loop; other site 1090974002092 phosphorylation site [posttranslational modification] 1090974002093 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1090974002094 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1090974002095 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1090974002096 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1090974002097 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1090974002098 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1090974002099 methionine cluster; other site 1090974002100 active site 1090974002101 phosphorylation site [posttranslational modification] 1090974002102 metal binding site [ion binding]; metal-binding site 1090974002103 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1090974002104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974002105 non-specific DNA binding site [nucleotide binding]; other site 1090974002106 salt bridge; other site 1090974002107 sequence-specific DNA binding site [nucleotide binding]; other site 1090974002108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1090974002109 binding surface 1090974002110 TPR motif; other site 1090974002111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1090974002112 ribonuclease HIII; Provisional; Region: PRK00996 1090974002113 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1090974002114 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1090974002115 RNA/DNA hybrid binding site [nucleotide binding]; other site 1090974002116 active site 1090974002117 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1090974002118 Sm and related proteins; Region: Sm_like; cl00259 1090974002119 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1090974002120 putative oligomer interface [polypeptide binding]; other site 1090974002121 putative RNA binding site [nucleotide binding]; other site 1090974002122 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1090974002123 NusA N-terminal domain; Region: NusA_N; pfam08529 1090974002124 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1090974002125 RNA binding site [nucleotide binding]; other site 1090974002126 homodimer interface [polypeptide binding]; other site 1090974002127 NusA-like KH domain; Region: KH_5; pfam13184 1090974002128 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1090974002129 G-X-X-G motif; other site 1090974002130 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1090974002131 putative RNA binding cleft [nucleotide binding]; other site 1090974002132 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1090974002133 GI:332686765; translation initiation factor 2 1090974002134 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1090974002135 Tic20-like protein; Region: Tic20; pfam09685 1090974002136 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1090974002137 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1090974002138 RNA binding site [nucleotide binding]; other site 1090974002139 active site 1090974002140 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1090974002141 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1090974002142 active site 1090974002143 Riboflavin kinase; Region: Flavokinase; smart00904 1090974002144 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1090974002145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1090974002146 FeS/SAM binding site; other site 1090974002147 HemN C-terminal domain; Region: HemN_C; pfam06969 1090974002148 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1090974002149 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1090974002150 GrpE; Region: GrpE; pfam01025 1090974002151 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1090974002152 dimer interface [polypeptide binding]; other site 1090974002153 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1090974002154 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1090974002155 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1090974002156 nucleotide binding site [chemical binding]; other site 1090974002157 NEF interaction site [polypeptide binding]; other site 1090974002158 SBD interface [polypeptide binding]; other site 1090974002159 chaperone protein DnaJ; Provisional; Region: PRK14276 1090974002160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1090974002161 HSP70 interaction site [polypeptide binding]; other site 1090974002162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1090974002163 substrate binding site [polypeptide binding]; other site 1090974002164 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1090974002165 Zn binding sites [ion binding]; other site 1090974002166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1090974002167 substrate binding site [polypeptide binding]; other site 1090974002168 dimer interface [polypeptide binding]; other site 1090974002169 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1090974002170 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1090974002171 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1090974002172 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1090974002173 RNA binding site [nucleotide binding]; other site 1090974002174 hypothetical protein; Provisional; Region: PRK04351 1090974002175 SprT homologues; Region: SprT; cl01182 1090974002176 GI:332686688; LysM domain-containing protein 1090974002177 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1090974002178 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1090974002179 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1090974002180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1090974002181 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1090974002182 Glycoprotease family; Region: Peptidase_M22; pfam00814 1090974002183 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1090974002184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974002185 Coenzyme A binding pocket [chemical binding]; other site 1090974002186 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1090974002187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974002188 Coenzyme A binding pocket [chemical binding]; other site 1090974002189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1090974002190 UGMP family protein; Validated; Region: PRK09604 1090974002191 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1090974002192 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1090974002193 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1090974002194 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1090974002195 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1090974002196 active site 1090974002197 HIGH motif; other site 1090974002198 KMSK motif region; other site 1090974002199 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1090974002200 tRNA binding surface [nucleotide binding]; other site 1090974002201 anticodon binding site; other site 1090974002202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974002203 Zn2+ binding site [ion binding]; other site 1090974002204 Mg2+ binding site [ion binding]; other site 1090974002205 hypothetical protein; Provisional; Region: PRK04387 1090974002206 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1090974002207 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1090974002208 active site 1090974002209 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1090974002210 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1090974002211 G1 box; other site 1090974002212 putative GEF interaction site [polypeptide binding]; other site 1090974002213 GTP/Mg2+ binding site [chemical binding]; other site 1090974002214 Switch I region; other site 1090974002215 G2 box; other site 1090974002216 G3 box; other site 1090974002217 Switch II region; other site 1090974002218 G4 box; other site 1090974002219 G5 box; other site 1090974002220 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1090974002221 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1090974002222 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1090974002223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974002224 ATP binding site [chemical binding]; other site 1090974002225 putative Mg++ binding site [ion binding]; other site 1090974002226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974002227 nucleotide binding region [chemical binding]; other site 1090974002228 ATP-binding site [chemical binding]; other site 1090974002229 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1090974002230 HRDC domain; Region: HRDC; pfam00570 1090974002231 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1090974002232 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1090974002233 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1090974002234 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1090974002235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974002236 S-adenosylmethionine binding site [chemical binding]; other site 1090974002237 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1090974002238 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1090974002239 active site 1090974002240 (T/H)XGH motif; other site 1090974002241 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1090974002242 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1090974002243 protein binding site [polypeptide binding]; other site 1090974002244 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1090974002245 SLBB domain; Region: SLBB; pfam10531 1090974002246 comEA protein; Region: comE; TIGR01259 1090974002247 dCMP deaminase, late competence protein ComEB 1090974002248 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1090974002249 Competence protein; Region: Competence; pfam03772 1090974002250 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1090974002251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1090974002252 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1090974002253 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1090974002254 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1090974002255 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1090974002256 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974002257 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1090974002258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974002259 catalytic core [active] 1090974002260 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1090974002261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1090974002262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1090974002263 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1090974002264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1090974002265 active site 1090974002266 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1090974002267 dimer interface [polypeptide binding]; other site 1090974002268 substrate binding site [chemical binding]; other site 1090974002269 ATP binding site [chemical binding]; other site 1090974002270 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1090974002271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974002272 DNA-binding site [nucleotide binding]; DNA binding site 1090974002273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974002275 homodimer interface [polypeptide binding]; other site 1090974002276 catalytic residue [active] 1090974002277 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1090974002278 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1090974002279 active site 1090974002280 substrate binding site [chemical binding]; other site 1090974002281 metal binding site [ion binding]; metal-binding site 1090974002282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1090974002283 dimerization interface [polypeptide binding]; other site 1090974002284 putative DNA binding site [nucleotide binding]; other site 1090974002285 putative Zn2+ binding site [ion binding]; other site 1090974002286 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1090974002287 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1090974002288 metal binding site 2 [ion binding]; metal-binding site 1090974002289 putative DNA binding helix; other site 1090974002290 metal binding site 1 [ion binding]; metal-binding site 1090974002291 dimer interface [polypeptide binding]; other site 1090974002292 structural Zn2+ binding site [ion binding]; other site 1090974002293 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1090974002294 Yqey-like protein; Region: YqeY; pfam09424 1090974002295 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1090974002296 PhoH-like protein; Region: PhoH; pfam02562 1090974002297 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1090974002298 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1090974002299 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974002300 Zn2+ binding site [ion binding]; other site 1090974002301 Mg2+ binding site [ion binding]; other site 1090974002302 metal-binding heat shock protein; Provisional; Region: PRK00016 1090974002303 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1090974002304 GTPase Era; Reviewed; Region: era; PRK00089 1090974002305 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1090974002306 Switch I region; other site 1090974002307 GTP/Mg2+ binding site [chemical binding]; other site 1090974002308 G2 box; other site 1090974002309 Switch II region; other site 1090974002310 G3 box; other site 1090974002311 G4 box; other site 1090974002312 G5 box; other site 1090974002313 KH domain; Region: KH_2; pfam07650 1090974002314 Recombination protein O N terminal; Region: RecO_N; pfam11967 1090974002315 DNA repair protein RecO; Region: reco; TIGR00613 1090974002316 Recombination protein O C terminal; Region: RecO_C; pfam02565 1090974002317 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1090974002318 dimer interface [polypeptide binding]; other site 1090974002319 motif 1; other site 1090974002320 active site 1090974002321 motif 2; other site 1090974002322 motif 3; other site 1090974002323 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1090974002324 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1090974002325 OxaA-like protein precursor; Provisional; Region: PRK02463 1090974002326 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1090974002327 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1090974002328 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1090974002329 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1090974002330 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1090974002331 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1090974002332 rRNA interaction site [nucleotide binding]; other site 1090974002333 S8 interaction site; other site 1090974002334 putative laminin-1 binding site; other site 1090974002335 elongation factor Ts; Provisional; Region: tsf; PRK09377 1090974002336 UBA/TS-N domain; Region: UBA; pfam00627 1090974002337 Elongation factor TS; Region: EF_TS; pfam00889 1090974002338 Elongation factor TS; Region: EF_TS; pfam00889 1090974002339 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1090974002340 putative nucleotide binding site [chemical binding]; other site 1090974002341 uridine monophosphate binding site [chemical binding]; other site 1090974002342 homohexameric interface [polypeptide binding]; other site 1090974002343 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1090974002344 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1090974002345 hinge region; other site 1090974002346 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1090974002347 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1090974002348 catalytic residue [active] 1090974002349 putative FPP diphosphate binding site; other site 1090974002350 putative FPP binding hydrophobic cleft; other site 1090974002351 dimer interface [polypeptide binding]; other site 1090974002352 putative IPP diphosphate binding site; other site 1090974002353 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1090974002354 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1090974002355 RIP metalloprotease RseP; Region: TIGR00054 1090974002356 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1090974002357 active site 1090974002358 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1090974002359 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1090974002360 protein binding site [polypeptide binding]; other site 1090974002361 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1090974002362 putative substrate binding region [chemical binding]; other site 1090974002363 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1090974002364 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1090974002365 dimer interface [polypeptide binding]; other site 1090974002366 motif 1; other site 1090974002367 active site 1090974002368 motif 2; other site 1090974002369 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1090974002370 putative deacylase active site [active] 1090974002371 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1090974002372 active site 1090974002373 motif 3; other site 1090974002374 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1090974002375 anticodon binding site; other site 1090974002376 DNA polymerase III alpha subunit; GI:332686699 1090974002377 GI:332686698; putative transport protein 1090974002378 DinG family ATP-dependent helicase YoaA; GI:332686697 1090974002379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1090974002380 lipoxygenase; Region: PLN02264 1090974002381 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1090974002382 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1090974002383 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974002384 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1090974002385 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1090974002386 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1090974002387 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1090974002388 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1090974002389 intersubunit interface [polypeptide binding]; other site 1090974002390 active site 1090974002391 zinc binding site [ion binding]; other site 1090974002392 Na+ binding site [ion binding]; other site 1090974002393 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1090974002394 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1090974002395 hinge; other site 1090974002396 active site 1090974002397 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1090974002398 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1090974002399 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1090974002400 RNA binding site [nucleotide binding]; other site 1090974002401 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1090974002402 multimer interface [polypeptide binding]; other site 1090974002403 Walker A motif; other site 1090974002404 ATP binding site [chemical binding]; other site 1090974002405 Walker B motif; other site 1090974002406 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1090974002407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974002408 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1090974002409 active site 1090974002410 catalytic residues [active] 1090974002411 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1090974002412 substrate binding site [chemical binding]; other site 1090974002413 active site 1090974002414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974002415 DNA-binding site [nucleotide binding]; DNA binding site 1090974002416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974002417 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1090974002418 putative dimerization interface [polypeptide binding]; other site 1090974002419 putative ligand binding site [chemical binding]; other site 1090974002420 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1090974002421 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1090974002422 putative N- and C-terminal domain interface [polypeptide binding]; other site 1090974002423 putative active site [active] 1090974002424 MgATP binding site [chemical binding]; other site 1090974002425 catalytic site [active] 1090974002426 metal binding site [ion binding]; metal-binding site 1090974002427 putative carbohydrate binding site [chemical binding]; other site 1090974002428 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1090974002429 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1090974002430 intersubunit interface [polypeptide binding]; other site 1090974002431 active site 1090974002432 Zn2+ binding site [ion binding]; other site 1090974002433 Predicted esterase [General function prediction only]; Region: COG0400 1090974002434 CsbD-like; Region: CsbD; cl17424 1090974002435 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1090974002436 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1090974002437 PYR/PP interface [polypeptide binding]; other site 1090974002438 dimer interface [polypeptide binding]; other site 1090974002439 tetramer interface [polypeptide binding]; other site 1090974002440 TPP binding site [chemical binding]; other site 1090974002441 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1090974002442 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1090974002443 TPP-binding site [chemical binding]; other site 1090974002444 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1090974002445 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1090974002446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1090974002447 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1090974002448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1090974002449 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1090974002450 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1090974002451 DNA binding site [nucleotide binding] 1090974002452 active site 1090974002453 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1090974002454 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1090974002455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974002456 active site 1090974002457 motif I; other site 1090974002458 motif II; other site 1090974002459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974002460 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1090974002461 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1090974002462 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1090974002463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974002464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974002465 active site 1090974002466 phosphorylation site [posttranslational modification] 1090974002467 intermolecular recognition site; other site 1090974002468 dimerization interface [polypeptide binding]; other site 1090974002469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974002470 DNA binding site [nucleotide binding] 1090974002471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974002472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1090974002473 dimerization interface [polypeptide binding]; other site 1090974002474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974002475 dimer interface [polypeptide binding]; other site 1090974002476 phosphorylation site [posttranslational modification] 1090974002477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974002478 ATP binding site [chemical binding]; other site 1090974002479 G-X-G motif; other site 1090974002480 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1090974002481 Sulfatase; Region: Sulfatase; pfam00884 1090974002482 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1090974002483 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1090974002484 putative RNA binding site [nucleotide binding]; other site 1090974002485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974002486 S-adenosylmethionine binding site [chemical binding]; other site 1090974002487 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1090974002488 putative deacylase active site [active] 1090974002489 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1090974002490 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1090974002491 Potassium binding sites [ion binding]; other site 1090974002492 Cesium cation binding sites [ion binding]; other site 1090974002493 lipoprotein signal peptidase; Provisional; Region: PRK14797 1090974002494 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1090974002495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1090974002496 RNA binding surface [nucleotide binding]; other site 1090974002497 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1090974002498 active site 1090974002499 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1090974002500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974002501 active site 1090974002502 GI:332686649; uracil permease 1090974002503 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1090974002504 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1090974002505 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1090974002506 dihydroorotase; Validated; Region: pyrC; PRK09357 1090974002507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1090974002508 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1090974002509 active site 1090974002510 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1090974002511 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1090974002512 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1090974002513 catalytic site [active] 1090974002514 subunit interface [polypeptide binding]; other site 1090974002515 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1090974002516 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1090974002517 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1090974002518 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1090974002519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1090974002520 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1090974002521 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1090974002522 IMP binding site; other site 1090974002523 dimer interface [polypeptide binding]; other site 1090974002524 interdomain contacts; other site 1090974002525 partial ornithine binding site; other site 1090974002526 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1090974002527 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1090974002528 FAD binding pocket [chemical binding]; other site 1090974002529 FAD binding motif [chemical binding]; other site 1090974002530 phosphate binding motif [ion binding]; other site 1090974002531 beta-alpha-beta structure motif; other site 1090974002532 NAD binding pocket [chemical binding]; other site 1090974002533 Iron coordination center [ion binding]; other site 1090974002534 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1090974002535 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1090974002536 heterodimer interface [polypeptide binding]; other site 1090974002537 active site 1090974002538 FMN binding site [chemical binding]; other site 1090974002539 homodimer interface [polypeptide binding]; other site 1090974002540 substrate binding site [chemical binding]; other site 1090974002541 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1090974002542 active site 1090974002543 dimer interface [polypeptide binding]; other site 1090974002544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974002545 active site 1090974002546 Predicted integral membrane protein [Function unknown]; Region: COG0392 1090974002547 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1090974002548 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1090974002549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1090974002550 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1090974002551 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1090974002552 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1090974002553 catalytic residue [active] 1090974002554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974002555 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1090974002556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974002557 motif II; other site 1090974002558 DNA primase, catalytic core; Region: dnaG; TIGR01391 1090974002559 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1090974002560 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1090974002561 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1090974002562 active site 1090974002563 metal binding site [ion binding]; metal-binding site 1090974002564 interdomain interaction site; other site 1090974002565 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1090974002566 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1090974002567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1090974002568 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1090974002569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1090974002570 DNA binding residues [nucleotide binding] 1090974002571 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1090974002572 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1090974002573 S1 domain; Region: S1_2; pfam13509 1090974002574 ferric uptake regulator; Provisional; Region: fur; PRK09462 1090974002575 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1090974002576 metal binding site 2 [ion binding]; metal-binding site 1090974002577 putative DNA binding helix; other site 1090974002578 metal binding site 1 [ion binding]; metal-binding site 1090974002579 dimer interface [polypeptide binding]; other site 1090974002580 structural Zn2+ binding site [ion binding]; other site 1090974002581 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1090974002582 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1090974002583 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1090974002584 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1090974002585 GTP1/OBG; Region: GTP1_OBG; pfam01018 1090974002586 Obg GTPase; Region: Obg; cd01898 1090974002587 G1 box; other site 1090974002588 GTP/Mg2+ binding site [chemical binding]; other site 1090974002589 Switch I region; other site 1090974002590 G2 box; other site 1090974002591 G3 box; other site 1090974002592 Switch II region; other site 1090974002593 G4 box; other site 1090974002594 G5 box; other site 1090974002595 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1090974002596 ribonuclease Z; Region: RNase_Z; TIGR02651 1090974002597 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1090974002598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974002599 NAD(P) binding site [chemical binding]; other site 1090974002600 active site 1090974002601 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1090974002602 DHH family; Region: DHH; pfam01368 1090974002603 DHHA1 domain; Region: DHHA1; pfam02272 1090974002604 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1090974002605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974002606 active site 1090974002607 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1090974002608 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1090974002609 putative active site [active] 1090974002610 metal binding site [ion binding]; metal-binding site 1090974002611 EDD domain protein, DegV family; Region: DegV; TIGR00762 1090974002612 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1090974002613 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1090974002614 active site 1090974002615 catalytic triad [active] 1090974002616 oxyanion hole [active] 1090974002617 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1090974002618 hypothetical protein; Provisional; Region: PRK13672 1090974002619 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1090974002620 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1090974002621 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1090974002622 protein binding site [polypeptide binding]; other site 1090974002623 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1090974002624 Catalytic dyad [active] 1090974002625 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1090974002626 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1090974002627 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1090974002628 Catalytic site [active] 1090974002629 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1090974002630 active site 1090974002631 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1090974002632 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1090974002633 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1090974002634 GTP/Mg2+ binding site [chemical binding]; other site 1090974002635 G4 box; other site 1090974002636 G5 box; other site 1090974002637 G1 box; other site 1090974002638 Switch I region; other site 1090974002639 G2 box; other site 1090974002640 G3 box; other site 1090974002641 Switch II region; other site 1090974002642 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1090974002643 RNA/DNA hybrid binding site [nucleotide binding]; other site 1090974002644 active site 1090974002645 DNA protecting protein DprA; Region: dprA; TIGR00732 1090974002646 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1090974002647 DNA topoisomerase I; Validated; Region: PRK05582 1090974002648 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1090974002649 active site 1090974002650 interdomain interaction site; other site 1090974002651 putative metal-binding site [ion binding]; other site 1090974002652 nucleotide binding site [chemical binding]; other site 1090974002653 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1090974002654 domain I; other site 1090974002655 DNA binding groove [nucleotide binding] 1090974002656 phosphate binding site [ion binding]; other site 1090974002657 domain II; other site 1090974002658 domain III; other site 1090974002659 nucleotide binding site [chemical binding]; other site 1090974002660 catalytic site [active] 1090974002661 domain IV; other site 1090974002662 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1090974002663 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1090974002664 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1090974002665 Glucose inhibited division protein A; Region: GIDA; pfam01134 1090974002666 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1090974002667 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1090974002668 active site 1090974002669 Int/Topo IB signature motif; other site 1090974002670 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1090974002671 active site 1090974002672 HslU subunit interaction site [polypeptide binding]; other site 1090974002673 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1090974002674 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1090974002675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974002676 Walker A motif; other site 1090974002677 ATP binding site [chemical binding]; other site 1090974002678 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1090974002679 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1090974002680 transcriptional repressor CodY; Validated; Region: PRK04158 1090974002681 CodY GAF-like domain; Region: CodY; pfam06018 1090974002682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1090974002683 putative DNA binding site [nucleotide binding]; other site 1090974002684 putative Zn2+ binding site [ion binding]; other site 1090974002685 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1090974002686 active site 1090974002687 catalytic residues [active] 1090974002688 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1090974002689 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1090974002690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974002691 ATP binding site [chemical binding]; other site 1090974002692 Mg2+ binding site [ion binding]; other site 1090974002693 G-X-G motif; other site 1090974002694 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1090974002695 anchoring element; other site 1090974002696 dimer interface [polypeptide binding]; other site 1090974002697 ATP binding site [chemical binding]; other site 1090974002698 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1090974002699 active site 1090974002700 putative metal-binding site [ion binding]; other site 1090974002701 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1090974002702 GI:332686600; topoisomerase IV subunit A 1090974002703 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1090974002704 Pyruvate formate lyase 1; Region: PFL1; cd01678 1090974002705 coenzyme A binding site [chemical binding]; other site 1090974002706 active site 1090974002707 catalytic residues [active] 1090974002708 glycine loop; other site 1090974002709 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1090974002710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1090974002711 FeS/SAM binding site; other site 1090974002712 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1090974002713 DHH family; Region: DHH; pfam01368 1090974002714 DHHA2 domain; Region: DHHA2; pfam02833 1090974002715 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1090974002716 Mga helix-turn-helix domain; Region: Mga; pfam05043 1090974002717 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1090974002718 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974002719 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1090974002720 Walker A/P-loop; other site 1090974002721 ATP binding site [chemical binding]; other site 1090974002722 Q-loop/lid; other site 1090974002723 ABC transporter signature motif; other site 1090974002724 Walker B; other site 1090974002725 D-loop; other site 1090974002726 H-loop/switch region; other site 1090974002727 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1090974002728 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1090974002729 CAT RNA binding domain; Region: CAT_RBD; smart01061 1090974002730 PRD domain; Region: PRD; pfam00874 1090974002731 PRD domain; Region: PRD; pfam00874 1090974002732 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1090974002733 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1090974002734 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1090974002735 active site turn [active] 1090974002736 phosphorylation site [posttranslational modification] 1090974002737 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1090974002738 HPr interaction site; other site 1090974002739 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1090974002740 active site 1090974002741 phosphorylation site [posttranslational modification] 1090974002742 arginine deiminase; Provisional; Region: PRK01388 1090974002743 ornithine carbamoyltransferase; Validated; Region: PRK02102 1090974002744 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1090974002745 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1090974002746 carbamate kinase; Reviewed; Region: PRK12686 1090974002747 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1090974002748 putative substrate binding site [chemical binding]; other site 1090974002749 nucleotide binding site [chemical binding]; other site 1090974002750 nucleotide binding site [chemical binding]; other site 1090974002751 homodimer interface [polypeptide binding]; other site 1090974002752 Predicted membrane protein [Function unknown]; Region: COG1288 1090974002753 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1090974002754 potential frameshift: common BLAST hit: gi|332687365|ref|YP_004457138.1| peptidoglycan-binding protein 1090974002755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974002756 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1090974002757 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1090974002758 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1090974002759 Predicted membrane protein [Function unknown]; Region: COG2364 1090974002760 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974002761 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1090974002762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1090974002763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1090974002764 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1090974002765 metal binding site 2 [ion binding]; metal-binding site 1090974002766 putative DNA binding helix; other site 1090974002767 metal binding site 1 [ion binding]; metal-binding site 1090974002768 dimer interface [polypeptide binding]; other site 1090974002769 structural Zn2+ binding site [ion binding]; other site 1090974002770 GI:332686573; transketolase 1090974002771 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1090974002772 LexA repressor; Validated; Region: PRK00215 1090974002773 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1090974002774 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1090974002775 Catalytic site [active] 1090974002776 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1090974002777 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1090974002778 folate binding site [chemical binding]; other site 1090974002779 NADP+ binding site [chemical binding]; other site 1090974002780 thymidylate synthase; Region: thym_sym; TIGR03284 1090974002781 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1090974002782 dimerization interface [polypeptide binding]; other site 1090974002783 active site 1090974002784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1090974002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974002786 Walker A/P-loop; other site 1090974002787 ATP binding site [chemical binding]; other site 1090974002788 Q-loop/lid; other site 1090974002789 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1090974002790 ABC transporter signature motif; other site 1090974002791 Walker B; other site 1090974002792 D-loop; other site 1090974002793 ABC transporter; Region: ABC_tran_2; pfam12848 1090974002794 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1090974002795 GI:332686567; Na+/H+ antiporter 1090974002796 shikimate kinase; Reviewed; Region: aroK; PRK00131 1090974002797 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1090974002798 ADP binding site [chemical binding]; other site 1090974002799 magnesium binding site [ion binding]; other site 1090974002800 putative shikimate binding site; other site 1090974002801 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1090974002802 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1090974002803 hinge; other site 1090974002804 active site 1090974002805 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1090974002806 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1090974002807 Tetramer interface [polypeptide binding]; other site 1090974002808 active site 1090974002809 FMN-binding site [chemical binding]; other site 1090974002810 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1090974002811 active site 1090974002812 dimer interface [polypeptide binding]; other site 1090974002813 metal binding site [ion binding]; metal-binding site 1090974002814 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1090974002815 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1090974002816 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1090974002817 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1090974002818 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1090974002819 shikimate binding site; other site 1090974002820 NAD(P) binding site [chemical binding]; other site 1090974002821 Predicted thioesterase [General function prediction only]; Region: COG5496 1090974002822 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1090974002823 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1090974002824 active site 1090974002825 NTP binding site [chemical binding]; other site 1090974002826 metal binding triad [ion binding]; metal-binding site 1090974002827 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1090974002828 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1090974002829 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1090974002830 homodimer interface [polypeptide binding]; other site 1090974002831 metal binding site [ion binding]; metal-binding site 1090974002832 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1090974002833 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974002834 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974002835 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1090974002836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1090974002837 binding surface 1090974002838 TPR motif; other site 1090974002839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1090974002840 TPR motif; other site 1090974002841 binding surface 1090974002842 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1090974002843 IHF dimer interface [polypeptide binding]; other site 1090974002844 IHF - DNA interface [nucleotide binding]; other site 1090974002845 GTP-binding protein Der; Reviewed; Region: PRK00093 1090974002846 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1090974002847 G1 box; other site 1090974002848 GTP/Mg2+ binding site [chemical binding]; other site 1090974002849 Switch I region; other site 1090974002850 G2 box; other site 1090974002851 Switch II region; other site 1090974002852 G3 box; other site 1090974002853 G4 box; other site 1090974002854 G5 box; other site 1090974002855 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1090974002856 G1 box; other site 1090974002857 GTP/Mg2+ binding site [chemical binding]; other site 1090974002858 Switch I region; other site 1090974002859 G2 box; other site 1090974002860 G3 box; other site 1090974002861 Switch II region; other site 1090974002862 G4 box; other site 1090974002863 G5 box; other site 1090974002864 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1090974002865 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1090974002866 RNA binding site [nucleotide binding]; other site 1090974002867 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1090974002868 RNA binding site [nucleotide binding]; other site 1090974002869 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1090974002870 RNA binding site [nucleotide binding]; other site 1090974002871 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1090974002872 RNA binding site [nucleotide binding]; other site 1090974002873 cytidylate kinase; Provisional; Region: cmk; PRK00023 1090974002874 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1090974002875 CMP-binding site; other site 1090974002876 The sites determining sugar specificity; other site 1090974002877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974002878 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1090974002879 Predicted membrane protein [Function unknown]; Region: COG3601 1090974002880 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1090974002881 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1090974002882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974002883 RNA binding surface [nucleotide binding]; other site 1090974002884 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1090974002885 active site 1090974002886 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1090974002887 GI:332686544; segregation and condensation protein A 1090974002888 tyrosine recombinase XerD 1090974002889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1090974002890 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1090974002891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1090974002892 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1090974002893 active site 1090974002894 Beta-lactamase; Region: Beta-lactamase; pfam00144 1090974002895 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1090974002896 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1090974002897 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1090974002898 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1090974002899 Isochorismatase family; Region: Isochorismatase; pfam00857 1090974002900 catalytic triad [active] 1090974002901 conserved cis-peptide bond; other site 1090974002902 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1090974002903 KH domain; Region: KH_4; pfam13083 1090974002904 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1090974002905 Predicted flavoprotein [General function prediction only]; Region: COG0431 1090974002906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1090974002907 signal recognition particle protein; Provisional; Region: PRK10867 1090974002908 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1090974002909 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1090974002910 P loop; other site 1090974002911 GTP binding site [chemical binding]; other site 1090974002912 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1090974002913 putative DNA-binding protein; Validated; Region: PRK00118 1090974002914 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1090974002915 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1090974002916 RimM N-terminal domain; Region: RimM; pfam01782 1090974002917 PRC-barrel domain; Region: PRC; pfam05239 1090974002918 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1090974002919 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1090974002920 ABC transporter ATP-binding protein; GI:332686526 1090974002921 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1090974002922 LytTr DNA-binding domain; Region: LytTR; pfam04397 1090974002923 manganese transport protein MntH; Reviewed; Region: PRK00701 1090974002924 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1090974002925 GI:332686523; glycerophosphoryl diester phosphodiesterase 1090974002926 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1090974002927 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1090974002928 minor groove reading motif; other site 1090974002929 helix-hairpin-helix signature motif; other site 1090974002930 substrate binding pocket [chemical binding]; other site 1090974002931 active site 1090974002932 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1090974002933 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1090974002934 Helix-turn-helix domain; Region: HTH_36; pfam13730 1090974002935 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1090974002936 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1090974002937 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1090974002938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1090974002939 cell division protein GpsB; Provisional; Region: PRK14127 1090974002940 DivIVA domain; Region: DivI1A_domain; TIGR03544 1090974002941 hypothetical protein; Provisional; Region: PRK13660 1090974002942 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1090974002943 Transglycosylase; Region: Transgly; pfam00912 1090974002944 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1090974002945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1090974002946 CTP synthetase; Validated; Region: pyrG; PRK05380 1090974002947 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1090974002948 Catalytic site [active] 1090974002949 active site 1090974002950 UTP binding site [chemical binding]; other site 1090974002951 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1090974002952 active site 1090974002953 putative oxyanion hole; other site 1090974002954 catalytic triad [active] 1090974002955 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1090974002956 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1090974002957 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1090974002958 putative phosphoketolase; Provisional; Region: PRK05261 1090974002959 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1090974002960 TPP-binding site; other site 1090974002961 XFP C-terminal domain; Region: XFP_C; pfam09363 1090974002962 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1090974002963 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1090974002964 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1090974002965 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1090974002966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974002967 Zn2+ binding site [ion binding]; other site 1090974002968 Mg2+ binding site [ion binding]; other site 1090974002969 sugar phosphate phosphatase; Provisional; Region: PRK10513 1090974002970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974002971 active site 1090974002972 motif I; other site 1090974002973 motif II; other site 1090974002974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1090974002975 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1090974002976 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1090974002977 dimer interface [polypeptide binding]; other site 1090974002978 active site 1090974002979 metal binding site [ion binding]; metal-binding site 1090974002980 glutathione binding site [chemical binding]; other site 1090974002981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1090974002982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1090974002983 active site 1090974002984 catalytic tetrad [active] 1090974002985 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1090974002986 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1090974002987 FOG: CBS domain [General function prediction only]; Region: COG0517 1090974002988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1090974002989 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1090974002990 active site 1090974002991 metal binding site [ion binding]; metal-binding site 1090974002992 homotetramer interface [polypeptide binding]; other site 1090974002993 ribonuclease PH; Reviewed; Region: rph; PRK00173 1090974002994 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1090974002995 hexamer interface [polypeptide binding]; other site 1090974002996 active site 1090974002997 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1090974002998 active site 1090974002999 dimerization interface [polypeptide binding]; other site 1090974003000 glutamate racemase; Provisional; Region: PRK00865 1090974003001 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1090974003002 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1090974003003 putative tRNA-binding site [nucleotide binding]; other site 1090974003004 B3/4 domain; Region: B3_4; pfam03483 1090974003005 tRNA synthetase B5 domain; Region: B5; smart00874 1090974003006 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1090974003007 dimer interface [polypeptide binding]; other site 1090974003008 motif 1; other site 1090974003009 motif 3; other site 1090974003010 motif 2; other site 1090974003011 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1090974003012 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1090974003013 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1090974003014 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1090974003015 dimer interface [polypeptide binding]; other site 1090974003016 motif 1; other site 1090974003017 active site 1090974003018 motif 2; other site 1090974003019 motif 3; other site 1090974003020 ATP-dependent nuclease subunit A; GI:332686494 1090974003021 ATP-dependent nuclease subunit B; GI:332686493 1090974003022 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1090974003023 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1090974003024 Catalytic site [active] 1090974003025 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1090974003026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1090974003027 active site 1090974003028 dimer interface [polypeptide binding]; other site 1090974003029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1090974003030 dimer interface [polypeptide binding]; other site 1090974003031 active site 1090974003032 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1090974003033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974003034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974003035 homodimer interface [polypeptide binding]; other site 1090974003036 catalytic residue [active] 1090974003037 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1090974003038 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1090974003039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003040 Walker A/P-loop; other site 1090974003041 ATP binding site [chemical binding]; other site 1090974003042 Q-loop/lid; other site 1090974003043 ABC transporter signature motif; other site 1090974003044 Walker B; other site 1090974003045 D-loop; other site 1090974003046 H-loop/switch region; other site 1090974003047 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1090974003048 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974003049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974003050 dimer interface [polypeptide binding]; other site 1090974003051 conserved gate region; other site 1090974003052 putative PBP binding loops; other site 1090974003053 ABC-ATPase subunit interface; other site 1090974003054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974003055 dimer interface [polypeptide binding]; other site 1090974003056 conserved gate region; other site 1090974003057 putative PBP binding loops; other site 1090974003058 ABC-ATPase subunit interface; other site 1090974003059 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974003060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974003061 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1090974003062 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1090974003063 GIY-YIG motif/motif A; other site 1090974003064 active site 1090974003065 catalytic site [active] 1090974003066 putative DNA binding site [nucleotide binding]; other site 1090974003067 metal binding site [ion binding]; metal-binding site 1090974003068 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1090974003069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1090974003070 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1090974003071 catalytic residues [active] 1090974003072 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1090974003073 MutS domain III; Region: MutS_III; pfam05192 1090974003074 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1090974003075 Walker A/P-loop; other site 1090974003076 ATP binding site [chemical binding]; other site 1090974003077 Q-loop/lid; other site 1090974003078 ABC transporter signature motif; other site 1090974003079 Walker B; other site 1090974003080 D-loop; other site 1090974003081 H-loop/switch region; other site 1090974003082 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1090974003083 Smr domain; Region: Smr; pfam01713 1090974003084 Colicin V production protein; Region: Colicin_V; pfam02674 1090974003085 Cell division protein ZapA; Region: ZapA; cl01146 1090974003086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1090974003087 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1090974003088 metal-binding site [ion binding] 1090974003089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974003090 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1090974003091 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1090974003092 thiamine phosphate binding site [chemical binding]; other site 1090974003093 active site 1090974003094 pyrophosphate binding site [ion binding]; other site 1090974003095 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1090974003096 dimer interface [polypeptide binding]; other site 1090974003097 substrate binding site [chemical binding]; other site 1090974003098 ATP binding site [chemical binding]; other site 1090974003099 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1090974003100 substrate binding site [chemical binding]; other site 1090974003101 multimerization interface [polypeptide binding]; other site 1090974003102 ATP binding site [chemical binding]; other site 1090974003103 Putative transcription activator [Transcription]; Region: TenA; COG0819 1090974003104 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1090974003105 peptidase T; Region: peptidase-T; TIGR01882 1090974003106 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1090974003107 metal binding site [ion binding]; metal-binding site 1090974003108 dimer interface [polypeptide binding]; other site 1090974003109 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1090974003110 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1090974003111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1090974003112 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1090974003113 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1090974003114 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1090974003115 Family of unknown function (DUF633); Region: DUF633; pfam04816 1090974003116 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1090974003117 FtsX-like permease family; Region: FtsX; pfam02687 1090974003118 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1090974003119 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1090974003120 FtsX-like permease family; Region: FtsX; pfam02687 1090974003121 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974003122 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974003123 Walker A/P-loop; other site 1090974003124 ATP binding site [chemical binding]; other site 1090974003125 Q-loop/lid; other site 1090974003126 ABC transporter signature motif; other site 1090974003127 Walker B; other site 1090974003128 D-loop; other site 1090974003129 H-loop/switch region; other site 1090974003130 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1090974003131 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1090974003132 active site 1090974003133 dimer interface [polypeptide binding]; other site 1090974003134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1090974003135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974003136 non-specific DNA binding site [nucleotide binding]; other site 1090974003137 salt bridge; other site 1090974003138 sequence-specific DNA binding site [nucleotide binding]; other site 1090974003139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1090974003140 aminotransferase AlaT; Validated; Region: PRK09265 1090974003141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974003142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974003143 homodimer interface [polypeptide binding]; other site 1090974003144 catalytic residue [active] 1090974003145 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1090974003146 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1090974003147 Ca binding site [ion binding]; other site 1090974003148 active site 1090974003149 catalytic site [active] 1090974003150 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1090974003151 GI:332686456; tRNA-specific adenosine-34 deaminase 1090974003152 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1090974003153 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1090974003154 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1090974003155 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1090974003156 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1090974003157 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1090974003158 motif 1; other site 1090974003159 active site 1090974003160 motif 2; other site 1090974003161 motif 3; other site 1090974003162 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1090974003163 DHHA1 domain; Region: DHHA1; pfam02272 1090974003164 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1090974003165 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1090974003166 ATP binding site [chemical binding]; other site 1090974003167 Mg++ binding site [ion binding]; other site 1090974003168 motif III; other site 1090974003169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974003170 nucleotide binding region [chemical binding]; other site 1090974003171 ATP-binding site [chemical binding]; other site 1090974003172 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1090974003173 DHH family; Region: DHH; pfam01368 1090974003174 DHHA1 domain; Region: DHHA1; pfam02272 1090974003175 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1090974003176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1090974003177 DNA-binding site [nucleotide binding]; DNA binding site 1090974003178 DRTGG domain; Region: DRTGG; pfam07085 1090974003179 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1090974003180 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1090974003181 active site 2 [active] 1090974003182 active site 1 [active] 1090974003183 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1090974003184 DNA-binding site [nucleotide binding]; DNA binding site 1090974003185 RNA-binding motif; other site 1090974003186 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1090974003187 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1090974003188 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1090974003189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1090974003190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1090974003191 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1090974003192 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1090974003193 E3 interaction surface; other site 1090974003194 lipoyl attachment site [posttranslational modification]; other site 1090974003195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1090974003196 E3 interaction surface; other site 1090974003197 lipoyl attachment site [posttranslational modification]; other site 1090974003198 e3 binding domain; Region: E3_binding; pfam02817 1090974003199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1090974003200 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1090974003201 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1090974003202 alpha subunit interface [polypeptide binding]; other site 1090974003203 TPP binding site [chemical binding]; other site 1090974003204 heterodimer interface [polypeptide binding]; other site 1090974003205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1090974003206 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1090974003207 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1090974003208 TPP-binding site [chemical binding]; other site 1090974003209 tetramer interface [polypeptide binding]; other site 1090974003210 heterodimer interface [polypeptide binding]; other site 1090974003211 phosphorylation loop region [posttranslational modification] 1090974003212 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1090974003213 magnesium-transporting ATPase; Provisional; Region: PRK15122 1090974003214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974003215 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1090974003216 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1090974003217 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1090974003218 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1090974003219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1090974003220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1090974003221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1090974003222 endonuclease IV; Provisional; Region: PRK01060 1090974003223 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1090974003224 AP (apurinic/apyrimidinic) site pocket; other site 1090974003225 DNA interaction; other site 1090974003226 Metal-binding active site; metal-binding site 1090974003227 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1090974003228 Transglycosylase; Region: Transgly; pfam00912 1090974003229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1090974003230 catabolite control protein A; Region: ccpA; TIGR01481 1090974003231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1090974003232 DNA binding site [nucleotide binding] 1090974003233 domain linker motif; other site 1090974003234 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1090974003235 dimerization interface [polypeptide binding]; other site 1090974003236 effector binding site; other site 1090974003237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1090974003238 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1090974003239 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1090974003240 active site 1090974003241 YtxH-like protein; Region: YtxH; pfam12732 1090974003242 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1090974003243 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1090974003244 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1090974003245 active site 1090974003246 tetramer interface; other site 1090974003247 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1090974003248 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1090974003249 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1090974003250 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1090974003251 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1090974003252 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1090974003253 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1090974003254 Hpr binding site; other site 1090974003255 active site 1090974003256 homohexamer subunit interaction site [polypeptide binding]; other site 1090974003257 Membrane protein of unknown function; Region: DUF360; cl00850 1090974003258 PspC domain; Region: PspC; pfam04024 1090974003259 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1090974003260 PhoU domain; Region: PhoU; pfam01895 1090974003261 PhoU domain; Region: PhoU; pfam01895 1090974003262 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1090974003263 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1090974003264 Walker A/P-loop; other site 1090974003265 ATP binding site [chemical binding]; other site 1090974003266 Q-loop/lid; other site 1090974003267 ABC transporter signature motif; other site 1090974003268 Walker B; other site 1090974003269 D-loop; other site 1090974003270 H-loop/switch region; other site 1090974003271 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1090974003272 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1090974003273 Walker A/P-loop; other site 1090974003274 ATP binding site [chemical binding]; other site 1090974003275 Q-loop/lid; other site 1090974003276 ABC transporter signature motif; other site 1090974003277 Walker B; other site 1090974003278 D-loop; other site 1090974003279 H-loop/switch region; other site 1090974003280 GI:332686418; phosphate transport system permease PstA 1090974003281 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1090974003282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974003283 dimer interface [polypeptide binding]; other site 1090974003284 conserved gate region; other site 1090974003285 putative PBP binding loops; other site 1090974003286 ABC-ATPase subunit interface; other site 1090974003287 periplasmic phosphate-binding protein PstS; phosphate ABC transporter 1090974003288 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1090974003289 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1090974003290 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1090974003291 putative active site [active] 1090974003292 catalytic site [active] 1090974003293 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1090974003294 putative active site [active] 1090974003295 catalytic site [active] 1090974003296 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1090974003297 FtsX-like permease family; Region: FtsX; pfam02687 1090974003298 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1090974003299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003300 Walker A/P-loop; other site 1090974003301 ATP binding site [chemical binding]; other site 1090974003302 Q-loop/lid; other site 1090974003303 ABC transporter signature motif; other site 1090974003304 Walker B; other site 1090974003305 D-loop; other site 1090974003306 H-loop/switch region; other site 1090974003307 peptide chain release factor 2; Provisional; Region: PRK06746 1090974003308 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1090974003309 RF-1 domain; Region: RF-1; pfam00472 1090974003310 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1090974003311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1090974003312 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1090974003313 nucleotide binding region [chemical binding]; other site 1090974003314 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1090974003315 ATP-binding site [chemical binding]; other site 1090974003316 SEC-C motif; Region: SEC-C; pfam02810 1090974003317 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1090974003318 30S subunit binding site; other site 1090974003319 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1090974003320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974003321 active site 1090974003322 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1090974003323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974003324 ATP binding site [chemical binding]; other site 1090974003325 putative Mg++ binding site [ion binding]; other site 1090974003326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974003327 nucleotide binding region [chemical binding]; other site 1090974003328 ATP-binding site [chemical binding]; other site 1090974003329 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1090974003330 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1090974003331 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1090974003332 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1090974003333 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1090974003334 classical (c) SDRs; Region: SDR_c; cd05233 1090974003335 NAD(P) binding site [chemical binding]; other site 1090974003336 active site 1090974003337 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1090974003338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974003339 DNA-binding site [nucleotide binding]; DNA binding site 1090974003340 UTRA domain; Region: UTRA; pfam07702 1090974003341 GI:332686403; activator of (R)-2-hydroxyglutaryl-CoA dehydratase 1090974003342 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1090974003343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1090974003344 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1090974003345 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1090974003346 quinolinate synthetase; Provisional; Region: PRK09375 1090974003347 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1090974003348 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1090974003349 dimerization interface [polypeptide binding]; other site 1090974003350 active site 1090974003351 L-aspartate oxidase; Region: nadB; TIGR00551 1090974003352 L-aspartate oxidase; Provisional; Region: PRK06175 1090974003353 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1090974003354 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1090974003355 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1090974003356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974003357 catalytic residue [active] 1090974003358 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1090974003359 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1090974003360 nucleotide binding site [chemical binding]; other site 1090974003361 Haemolytic domain; Region: Haemolytic; pfam01809 1090974003362 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1090974003363 G1 box; other site 1090974003364 GTP/Mg2+ binding site [chemical binding]; other site 1090974003365 Switch I region; other site 1090974003366 G2 box; other site 1090974003367 G3 box; other site 1090974003368 Switch II region; other site 1090974003369 G4 box; other site 1090974003370 G5 box; other site 1090974003371 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1090974003372 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1090974003373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974003374 Walker A motif; other site 1090974003375 ATP binding site [chemical binding]; other site 1090974003376 Walker B motif; other site 1090974003377 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1090974003378 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1090974003379 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1090974003380 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1090974003381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974003382 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1090974003383 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1090974003384 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1090974003385 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1090974003386 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1090974003387 N- and C-terminal domain interface [polypeptide binding]; other site 1090974003388 active site 1090974003389 catalytic site [active] 1090974003390 metal binding site [ion binding]; metal-binding site 1090974003391 carbohydrate binding site [chemical binding]; other site 1090974003392 ATP binding site [chemical binding]; other site 1090974003393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1090974003394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974003395 putative substrate translocation pore; other site 1090974003396 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1090974003397 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1090974003398 enolase; Provisional; Region: eno; PRK00077 1090974003399 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1090974003400 dimer interface [polypeptide binding]; other site 1090974003401 metal binding site [ion binding]; metal-binding site 1090974003402 substrate binding pocket [chemical binding]; other site 1090974003403 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1090974003404 triosephosphate isomerase; Provisional; Region: PRK14565 1090974003405 substrate binding site [chemical binding]; other site 1090974003406 dimer interface [polypeptide binding]; other site 1090974003407 catalytic triad [active] 1090974003408 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1090974003409 Phosphoglycerate kinase; Region: PGK; pfam00162 1090974003410 substrate binding site [chemical binding]; other site 1090974003411 hinge regions; other site 1090974003412 ADP binding site [chemical binding]; other site 1090974003413 catalytic site [active] 1090974003414 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1090974003415 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1090974003416 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1090974003417 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1090974003418 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1090974003419 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1090974003420 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974003421 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1090974003422 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1090974003423 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1090974003424 Clp amino terminal domain; Region: Clp_N; pfam02861 1090974003425 Clp amino terminal domain; Region: Clp_N; pfam02861 1090974003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974003427 Walker A motif; other site 1090974003428 ATP binding site [chemical binding]; other site 1090974003429 Walker B motif; other site 1090974003430 arginine finger; other site 1090974003431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974003432 Walker A motif; other site 1090974003433 ATP binding site [chemical binding]; other site 1090974003434 Walker B motif; other site 1090974003435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1090974003436 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1090974003437 magnesium-transporting ATPase; Provisional; Region: PRK15122 1090974003438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1090974003439 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1090974003440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974003441 motif II; other site 1090974003442 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1090974003443 Phosphotransferase enzyme family; Region: APH; pfam01636 1090974003444 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1090974003445 active site 1090974003446 substrate binding site [chemical binding]; other site 1090974003447 ATP binding site [chemical binding]; other site 1090974003448 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1090974003449 substrate binding site [chemical binding]; other site 1090974003450 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1090974003451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1090974003452 FeS/SAM binding site; other site 1090974003453 GI:332686367; cell division protein FtsK 1090974003454 DNA topoisomerase III; Provisional; Region: PRK07726 1090974003455 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1090974003456 active site 1090974003457 putative interdomain interaction site [polypeptide binding]; other site 1090974003458 putative metal-binding site [ion binding]; other site 1090974003459 putative nucleotide binding site [chemical binding]; other site 1090974003460 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1090974003461 domain I; other site 1090974003462 DNA binding groove [nucleotide binding] 1090974003463 phosphate binding site [ion binding]; other site 1090974003464 domain II; other site 1090974003465 domain III; other site 1090974003466 nucleotide binding site [chemical binding]; other site 1090974003467 catalytic site [active] 1090974003468 domain IV; other site 1090974003469 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1090974003470 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1090974003471 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1090974003472 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1090974003473 Putative amino acid metabolism; Region: DUF1831; pfam08866 1090974003474 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1090974003475 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1090974003476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974003477 catalytic residue [active] 1090974003478 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1090974003479 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1090974003480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1090974003481 active site 1090974003482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1090974003483 Beta-lactamase; Region: Beta-lactamase; pfam00144 1090974003484 SWIM zinc finger; Region: SWIM; pfam04434 1090974003485 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1090974003486 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1090974003487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974003488 ATP binding site [chemical binding]; other site 1090974003489 putative Mg++ binding site [ion binding]; other site 1090974003490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974003491 nucleotide binding region [chemical binding]; other site 1090974003492 ATP-binding site [chemical binding]; other site 1090974003493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003494 Q-loop/lid; other site 1090974003495 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1090974003496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003497 ABC transporter signature motif; other site 1090974003498 Walker B; other site 1090974003499 D-loop; other site 1090974003500 H-loop/switch region; other site 1090974003501 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1090974003502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003503 Walker A/P-loop; other site 1090974003504 ATP binding site [chemical binding]; other site 1090974003505 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1090974003506 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1090974003507 active site 1090974003508 metal binding site [ion binding]; metal-binding site 1090974003509 DNA binding site [nucleotide binding] 1090974003510 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1090974003511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1090974003512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1090974003513 putative acyl-acceptor binding pocket; other site 1090974003514 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1090974003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974003516 S-adenosylmethionine binding site [chemical binding]; other site 1090974003517 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1090974003518 GIY-YIG motif/motif A; other site 1090974003519 putative active site [active] 1090974003520 putative metal binding site [ion binding]; other site 1090974003521 Isochorismatase family; Region: Isochorismatase; pfam00857 1090974003522 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1090974003523 catalytic triad [active] 1090974003524 conserved cis-peptide bond; other site 1090974003525 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1090974003526 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1090974003527 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1090974003528 dimer interface [polypeptide binding]; other site 1090974003529 ADP-ribose binding site [chemical binding]; other site 1090974003530 active site 1090974003531 nudix motif; other site 1090974003532 metal binding site [ion binding]; metal-binding site 1090974003533 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1090974003534 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1090974003535 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1090974003536 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1090974003537 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1090974003538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003539 Walker A/P-loop; other site 1090974003540 ATP binding site [chemical binding]; other site 1090974003541 Q-loop/lid; other site 1090974003542 ABC transporter signature motif; other site 1090974003543 Walker B; other site 1090974003544 D-loop; other site 1090974003545 H-loop/switch region; other site 1090974003546 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1090974003547 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1090974003548 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1090974003549 glutaminase active site [active] 1090974003550 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1090974003551 dimer interface [polypeptide binding]; other site 1090974003552 active site 1090974003553 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1090974003554 dimer interface [polypeptide binding]; other site 1090974003555 active site 1090974003556 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1090974003557 potential frameshift: common BLAST hit: gi|332686338|ref|YP_004456112.1| ECF transporter ATPase 1090974003558 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1090974003559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003560 ABC transporter signature motif; other site 1090974003561 Walker B; other site 1090974003562 D-loop; other site 1090974003563 H-loop/switch region; other site 1090974003564 potential frameshift: common BLAST hit: gi|332686338|ref|YP_004456112.1| ECF transporter ATPase 1090974003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003566 Walker B; other site 1090974003567 D-loop; other site 1090974003568 H-loop/switch region; other site 1090974003569 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1090974003570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1090974003571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003572 Walker A/P-loop; other site 1090974003573 ATP binding site [chemical binding]; other site 1090974003574 Q-loop/lid; other site 1090974003575 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1090974003576 Walker A/P-loop; other site 1090974003577 ATP binding site [chemical binding]; other site 1090974003578 Q-loop/lid; other site 1090974003579 hypothetical protein; Provisional; Region: PRK13661 1090974003580 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1090974003581 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1090974003582 active site 1090974003583 substrate binding site [chemical binding]; other site 1090974003584 metal binding site [ion binding]; metal-binding site 1090974003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1090974003586 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1090974003587 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1090974003588 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1090974003589 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1090974003590 dimer interface [polypeptide binding]; other site 1090974003591 PYR/PP interface [polypeptide binding]; other site 1090974003592 TPP binding site [chemical binding]; other site 1090974003593 substrate binding site [chemical binding]; other site 1090974003594 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1090974003595 Domain of unknown function; Region: EKR; cl11037 1090974003596 4Fe-4S binding domain; Region: Fer4; pfam00037 1090974003597 4Fe-4S binding domain; Region: Fer4; pfam00037 1090974003598 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1090974003599 TPP-binding site [chemical binding]; other site 1090974003600 dimer interface [polypeptide binding]; other site 1090974003601 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1090974003602 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1090974003603 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1090974003604 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1090974003605 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1090974003606 DNA binding residues [nucleotide binding] 1090974003607 putative dimer interface [polypeptide binding]; other site 1090974003608 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1090974003609 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1090974003610 HflX GTPase family; Region: HflX; cd01878 1090974003611 G1 box; other site 1090974003612 GTP/Mg2+ binding site [chemical binding]; other site 1090974003613 Switch I region; other site 1090974003614 G2 box; other site 1090974003615 G3 box; other site 1090974003616 Switch II region; other site 1090974003617 G4 box; other site 1090974003618 G5 box; other site 1090974003619 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1090974003620 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1090974003621 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1090974003622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974003623 NAD(P) binding site [chemical binding]; other site 1090974003624 active site 1090974003625 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1090974003626 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1090974003627 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1090974003628 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1090974003629 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1090974003630 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1090974003631 O-Antigen ligase; Region: Wzy_C; pfam04932 1090974003632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974003633 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1090974003634 NAD(P) binding site [chemical binding]; other site 1090974003635 active site 1090974003636 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1090974003637 substrate binding site; other site 1090974003638 dimer interface; other site 1090974003639 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974003640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1090974003641 active site 1090974003642 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974003643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1090974003644 active site 1090974003645 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1090974003646 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1090974003647 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974003648 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1090974003649 Probable Catalytic site; other site 1090974003650 metal-binding site 1090974003651 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1090974003652 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1090974003653 Probable Catalytic site; other site 1090974003654 metal-binding site 1090974003655 glycosyl transferase, group 2 family protein 1090974003656 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1090974003657 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1090974003658 Walker A/P-loop; other site 1090974003659 ATP binding site [chemical binding]; other site 1090974003660 Q-loop/lid; other site 1090974003661 ABC transporter signature motif; other site 1090974003662 Walker B; other site 1090974003663 D-loop; other site 1090974003664 H-loop/switch region; other site 1090974003665 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1090974003666 putative carbohydrate binding site [chemical binding]; other site 1090974003667 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1090974003668 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1090974003669 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1090974003670 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974003671 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1090974003672 Ligand binding site; other site 1090974003673 Putative Catalytic site; other site 1090974003674 DXD motif; other site 1090974003675 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1090974003676 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1090974003677 NADP binding site [chemical binding]; other site 1090974003678 active site 1090974003679 putative substrate binding site [chemical binding]; other site 1090974003680 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1090974003681 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1090974003682 NAD binding site [chemical binding]; other site 1090974003683 substrate binding site [chemical binding]; other site 1090974003684 homodimer interface [polypeptide binding]; other site 1090974003685 active site 1090974003686 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1090974003687 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1090974003688 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1090974003689 substrate binding site; other site 1090974003690 tetramer interface; other site 1090974003691 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974003692 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1090974003693 Probable Catalytic site; other site 1090974003694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1090974003695 active site 1090974003696 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1090974003697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1090974003698 active site 1090974003699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1090974003700 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1090974003701 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1090974003702 Mg++ binding site [ion binding]; other site 1090974003703 putative catalytic motif [active] 1090974003704 substrate binding site [chemical binding]; other site 1090974003705 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1090974003706 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1090974003707 active site 1090974003708 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1090974003709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974003710 putative substrate translocation pore; other site 1090974003711 flavodoxin; Validated; Region: PRK07308 1090974003712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1090974003713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1090974003714 WHG domain; Region: WHG; pfam13305 1090974003715 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1090974003716 beta-galactosidase; Region: BGL; TIGR03356 1090974003717 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1090974003718 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1090974003719 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1090974003720 active site 1090974003721 methionine cluster; other site 1090974003722 phosphorylation site [posttranslational modification] 1090974003723 metal binding site [ion binding]; metal-binding site 1090974003724 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1090974003725 active site 1090974003726 P-loop; other site 1090974003727 phosphorylation site [posttranslational modification] 1090974003728 GI:332686287; NtrC family transcriptional regulator 1090974003729 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1090974003730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1090974003731 ATP binding site [chemical binding]; other site 1090974003732 putative Mg++ binding site [ion binding]; other site 1090974003733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974003734 nucleotide binding region [chemical binding]; other site 1090974003735 ATP-binding site [chemical binding]; other site 1090974003736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1090974003737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1090974003738 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1090974003739 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1090974003740 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1090974003741 FeoA domain; Region: FeoA; pfam04023 1090974003742 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1090974003743 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1090974003744 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1090974003745 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1090974003746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1090974003747 active site 1090974003748 HIGH motif; other site 1090974003749 nucleotide binding site [chemical binding]; other site 1090974003750 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1090974003751 active site 1090974003752 KMSKS motif; other site 1090974003753 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1090974003754 tRNA binding surface [nucleotide binding]; other site 1090974003755 anticodon binding site; other site 1090974003756 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1090974003757 DivIVA protein; Region: DivIVA; pfam05103 1090974003758 DivIVA domain; Region: DivI1A_domain; TIGR03544 1090974003759 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1090974003760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974003761 RNA binding surface [nucleotide binding]; other site 1090974003762 YGGT family; Region: YGGT; pfam02325 1090974003763 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1090974003764 cell division protein FtsZ; Validated; Region: PRK09330 1090974003765 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1090974003766 nucleotide binding site [chemical binding]; other site 1090974003767 SulA interaction site; other site 1090974003768 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1090974003769 Cell division protein FtsA; Region: FtsA; smart00842 1090974003770 Cell division protein FtsA; Region: FtsA; pfam14450 1090974003771 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1090974003772 GI:332686274; cell division protein FtsQ 1090974003773 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1090974003774 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1090974003775 active site 1090974003776 homodimer interface [polypeptide binding]; other site 1090974003777 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1090974003778 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1090974003779 NAD binding site [chemical binding]; other site 1090974003780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1090974003781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1090974003782 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1090974003783 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1090974003784 Mg++ binding site [ion binding]; other site 1090974003785 putative catalytic motif [active] 1090974003786 putative substrate binding site [chemical binding]; other site 1090974003787 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1090974003788 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1090974003789 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1090974003790 MraW methylase family; Region: Methyltransf_5; pfam01795 1090974003791 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1090974003792 cell division protein MraZ; Reviewed; Region: PRK00326 1090974003793 MraZ protein; Region: MraZ; pfam02381 1090974003794 MraZ protein; Region: MraZ; pfam02381 1090974003795 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1090974003796 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1090974003797 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1090974003798 Cl binding site [ion binding]; other site 1090974003799 oligomer interface [polypeptide binding]; other site 1090974003800 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1090974003801 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1090974003802 Walker A/P-loop; other site 1090974003803 ATP binding site [chemical binding]; other site 1090974003804 Q-loop/lid; other site 1090974003805 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1090974003806 ABC transporter signature motif; other site 1090974003807 Walker B; other site 1090974003808 D-loop; other site 1090974003809 H-loop/switch region; other site 1090974003810 Arginine repressor [Transcription]; Region: ArgR; COG1438 1090974003811 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1090974003812 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1090974003813 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1090974003814 S4 RNA-binding domain; Region: S4; smart00363 1090974003815 RNA binding surface [nucleotide binding]; other site 1090974003816 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1090974003817 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1090974003818 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1090974003819 substrate binding pocket [chemical binding]; other site 1090974003820 chain length determination region; other site 1090974003821 substrate-Mg2+ binding site; other site 1090974003822 catalytic residues [active] 1090974003823 aspartate-rich region 1; other site 1090974003824 active site lid residues [active] 1090974003825 aspartate-rich region 2; other site 1090974003826 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1090974003827 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1090974003828 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1090974003829 generic binding surface II; other site 1090974003830 generic binding surface I; other site 1090974003831 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1090974003832 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1090974003833 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1090974003834 homodimer interface [polypeptide binding]; other site 1090974003835 NADP binding site [chemical binding]; other site 1090974003836 substrate binding site [chemical binding]; other site 1090974003837 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1090974003838 putative RNA binding site [nucleotide binding]; other site 1090974003839 Asp23 family; Region: Asp23; pfam03780 1090974003840 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1090974003841 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1090974003842 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1090974003843 active site 1090974003844 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1090974003845 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1090974003846 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1090974003847 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1090974003848 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1090974003849 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1090974003850 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1090974003851 ArsC family; Region: ArsC; pfam03960 1090974003852 putative catalytic residues [active] 1090974003853 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1090974003854 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1090974003855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974003856 Coenzyme A binding pocket [chemical binding]; other site 1090974003857 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1090974003858 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1090974003859 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1090974003860 active site 1090974003861 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1090974003862 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1090974003863 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1090974003864 synthetase active site [active] 1090974003865 NTP binding site [chemical binding]; other site 1090974003866 metal binding site [ion binding]; metal-binding site 1090974003867 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1090974003868 putative active site [active] 1090974003869 putative metal binding residues [ion binding]; other site 1090974003870 signature motif; other site 1090974003871 putative triphosphate binding site [ion binding]; other site 1090974003872 Thioredoxin; Region: Thioredoxin_5; pfam13743 1090974003873 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1090974003874 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1090974003875 active site 1090974003876 Zn binding site [ion binding]; other site 1090974003877 Competence protein CoiA-like family; Region: CoiA; cl11541 1090974003878 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1090974003879 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1090974003880 ArsC family; Region: ArsC; pfam03960 1090974003881 putative catalytic residues [active] 1090974003882 thiol/disulfide switch; other site 1090974003883 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1090974003884 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1090974003885 active site 1090974003886 HIGH motif; other site 1090974003887 dimer interface [polypeptide binding]; other site 1090974003888 KMSKS motif; other site 1090974003889 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1090974003890 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1090974003891 ligand binding site [chemical binding]; other site 1090974003892 active site 1090974003893 UGI interface [polypeptide binding]; other site 1090974003894 catalytic site [active] 1090974003895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974003896 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1090974003897 active site 1090974003898 motif I; other site 1090974003899 motif II; other site 1090974003900 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1090974003901 Tubby C 2; Region: Tub_2; cl02043 1090974003902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1090974003903 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1090974003904 Coenzyme A binding pocket [chemical binding]; other site 1090974003905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1090974003906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1090974003907 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974003908 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974003909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974003910 Walker A/P-loop; other site 1090974003911 ATP binding site [chemical binding]; other site 1090974003912 Q-loop/lid; other site 1090974003913 ABC transporter signature motif; other site 1090974003914 Walker B; other site 1090974003915 D-loop; other site 1090974003916 H-loop/switch region; other site 1090974003917 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974003918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974003919 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1090974003920 Walker A/P-loop; other site 1090974003921 ATP binding site [chemical binding]; other site 1090974003922 Q-loop/lid; other site 1090974003923 ABC transporter signature motif; other site 1090974003924 Walker B; other site 1090974003925 D-loop; other site 1090974003926 H-loop/switch region; other site 1090974003927 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1090974003928 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1090974003929 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1090974003930 active site 1090974003931 dimer interfaces [polypeptide binding]; other site 1090974003932 catalytic residues [active] 1090974003933 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1090974003934 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1090974003935 Walker A/P-loop; other site 1090974003936 ATP binding site [chemical binding]; other site 1090974003937 Q-loop/lid; other site 1090974003938 ABC transporter signature motif; other site 1090974003939 Walker B; other site 1090974003940 D-loop; other site 1090974003941 H-loop/switch region; other site 1090974003942 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1090974003943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974003944 S-adenosylmethionine binding site [chemical binding]; other site 1090974003945 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1090974003946 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1090974003947 putative active site [active] 1090974003948 putative metal binding site [ion binding]; other site 1090974003949 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1090974003950 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1090974003951 active site 1090974003952 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1090974003953 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1090974003954 active site 1090974003955 HIGH motif; other site 1090974003956 KMSKS motif; other site 1090974003957 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1090974003958 tRNA binding surface [nucleotide binding]; other site 1090974003959 anticodon binding site; other site 1090974003960 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1090974003961 dimer interface [polypeptide binding]; other site 1090974003962 putative tRNA-binding site [nucleotide binding]; other site 1090974003963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974003964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974003965 dimer interface [polypeptide binding]; other site 1090974003966 phosphorylation site [posttranslational modification] 1090974003967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974003968 ATP binding site [chemical binding]; other site 1090974003969 Mg2+ binding site [ion binding]; other site 1090974003970 G-X-G motif; other site 1090974003971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974003972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974003973 active site 1090974003974 phosphorylation site [posttranslational modification] 1090974003975 intermolecular recognition site; other site 1090974003976 dimerization interface [polypeptide binding]; other site 1090974003977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974003978 DNA binding site [nucleotide binding] 1090974003979 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1090974003980 23S rRNA binding site [nucleotide binding]; other site 1090974003981 L21 binding site [polypeptide binding]; other site 1090974003982 L13 binding site [polypeptide binding]; other site 1090974003983 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1090974003984 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1090974003985 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1090974003986 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1090974003987 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1090974003988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1090974003989 Walker A/P-loop; other site 1090974003990 ATP binding site [chemical binding]; other site 1090974003991 Q-loop/lid; other site 1090974003992 ABC transporter signature motif; other site 1090974003993 Walker B; other site 1090974003994 D-loop; other site 1090974003995 H-loop/switch region; other site 1090974003996 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1090974003997 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1090974003998 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1090974003999 Walker A/P-loop; other site 1090974004000 ATP binding site [chemical binding]; other site 1090974004001 Q-loop/lid; other site 1090974004002 ABC transporter signature motif; other site 1090974004003 Walker B; other site 1090974004004 D-loop; other site 1090974004005 H-loop/switch region; other site 1090974004006 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1090974004007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1090974004008 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1090974004009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004010 dimer interface [polypeptide binding]; other site 1090974004011 conserved gate region; other site 1090974004012 putative PBP binding loops; other site 1090974004013 ABC-ATPase subunit interface; other site 1090974004014 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1090974004015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004016 dimer interface [polypeptide binding]; other site 1090974004017 conserved gate region; other site 1090974004018 putative PBP binding loops; other site 1090974004019 ABC-ATPase subunit interface; other site 1090974004020 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1090974004021 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1090974004022 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1090974004023 peptide binding site [polypeptide binding]; other site 1090974004024 mevalonate kinase; Region: mevalon_kin; TIGR00549 1090974004025 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1090974004026 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1090974004027 diphosphomevalonate decarboxylase; Region: PLN02407 1090974004028 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1090974004029 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1090974004030 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1090974004031 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1090974004032 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1090974004033 putative active site [active] 1090974004034 FMN binding site [chemical binding]; other site 1090974004035 putative substrate binding site [chemical binding]; other site 1090974004036 homotetramer interface [polypeptide binding]; other site 1090974004037 Predicted membrane protein [Function unknown]; Region: COG1511 1090974004038 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1090974004039 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1090974004040 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1090974004041 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1090974004042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1090974004043 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1090974004044 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1090974004045 putative catalytic cysteine [active] 1090974004046 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1090974004047 putative active site [active] 1090974004048 metal binding site [ion binding]; metal-binding site 1090974004049 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1090974004050 Preprotein translocase subunit; Region: YajC; pfam02699 1090974004051 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1090974004052 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1090974004053 GI:332686191; amino acid ABC transporter amino acid-binding/ permease 1090974004054 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1090974004055 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1090974004056 Walker A/P-loop; other site 1090974004057 ATP binding site [chemical binding]; other site 1090974004058 Q-loop/lid; other site 1090974004059 ABC transporter signature motif; other site 1090974004060 Walker B; other site 1090974004061 D-loop; other site 1090974004062 H-loop/switch region; other site 1090974004063 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1090974004064 nudix motif; other site 1090974004065 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1090974004066 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1090974004067 putative NAD(P) binding site [chemical binding]; other site 1090974004068 dimer interface [polypeptide binding]; other site 1090974004069 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1090974004070 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1090974004071 catalytic triad [active] 1090974004072 catalytic triad [active] 1090974004073 oxyanion hole [active] 1090974004074 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1090974004075 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1090974004076 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1090974004077 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1090974004078 Clp protease; Region: CLP_protease; pfam00574 1090974004079 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1090974004080 oligomer interface [polypeptide binding]; other site 1090974004081 active site residues [active] 1090974004082 Thioredoxin; Region: Thioredoxin_4; pfam13462 1090974004083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1090974004084 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1090974004085 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1090974004086 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1090974004087 phosphate binding site [ion binding]; other site 1090974004088 putative substrate binding pocket [chemical binding]; other site 1090974004089 dimer interface [polypeptide binding]; other site 1090974004090 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1090974004091 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1090974004092 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1090974004093 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1090974004094 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1090974004095 excinuclease ABC subunit B; Provisional; Region: PRK05298 1090974004096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1090974004097 ATP binding site [chemical binding]; other site 1090974004098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1090974004099 nucleotide binding region [chemical binding]; other site 1090974004100 ATP-binding site [chemical binding]; other site 1090974004101 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1090974004102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1090974004103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1090974004104 substrate binding pocket [chemical binding]; other site 1090974004105 membrane-bound complex binding site; other site 1090974004106 hinge residues; other site 1090974004107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004108 dimer interface [polypeptide binding]; other site 1090974004109 conserved gate region; other site 1090974004110 putative PBP binding loops; other site 1090974004111 ABC-ATPase subunit interface; other site 1090974004112 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1090974004113 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1090974004114 Walker A/P-loop; other site 1090974004115 ATP binding site [chemical binding]; other site 1090974004116 Q-loop/lid; other site 1090974004117 ABC transporter signature motif; other site 1090974004118 Walker B; other site 1090974004119 D-loop; other site 1090974004120 H-loop/switch region; other site 1090974004121 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1090974004122 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1090974004123 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1090974004124 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1090974004125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974004126 S-adenosylmethionine binding site [chemical binding]; other site 1090974004127 putative lipid kinase; Reviewed; Region: PRK13055 1090974004128 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1090974004129 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1090974004130 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1090974004131 GatB domain; Region: GatB_Yqey; pfam02637 1090974004132 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1090974004133 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1090974004134 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1090974004135 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1090974004136 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1090974004137 nucleotide binding pocket [chemical binding]; other site 1090974004138 K-X-D-G motif; other site 1090974004139 catalytic site [active] 1090974004140 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1090974004141 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1090974004142 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1090974004143 Dimer interface [polypeptide binding]; other site 1090974004144 BRCT sequence motif; other site 1090974004145 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1090974004146 Part of AAA domain; Region: AAA_19; pfam13245 1090974004147 Family description; Region: UvrD_C_2; pfam13538 1090974004148 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1090974004149 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1090974004150 active site 1090974004151 Na/Ca binding site [ion binding]; other site 1090974004152 catalytic site [active] 1090974004153 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1090974004154 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1090974004155 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1090974004156 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1090974004157 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1090974004158 putative substrate binding site [chemical binding]; other site 1090974004159 putative ATP binding site [chemical binding]; other site 1090974004160 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1090974004161 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1090974004162 active site 1090974004163 phosphorylation site [posttranslational modification] 1090974004164 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1090974004165 active site 1090974004166 P-loop; other site 1090974004167 phosphorylation site [posttranslational modification] 1090974004168 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1090974004169 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1090974004170 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1090974004171 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1090974004172 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1090974004173 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1090974004174 dimerization domain swap beta strand [polypeptide binding]; other site 1090974004175 regulatory protein interface [polypeptide binding]; other site 1090974004176 active site 1090974004177 regulatory phosphorylation site [posttranslational modification]; other site 1090974004178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974004179 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1090974004180 Walker A motif; other site 1090974004181 ATP binding site [chemical binding]; other site 1090974004182 Walker B motif; other site 1090974004183 arginine finger; other site 1090974004184 UvrB/uvrC motif; Region: UVR; pfam02151 1090974004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974004186 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1090974004187 Walker A motif; other site 1090974004188 ATP binding site [chemical binding]; other site 1090974004189 Walker B motif; other site 1090974004190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1090974004191 hypothetical protein; Provisional; Region: PRK13676 1090974004192 Transglycosylase; Region: Transgly; pfam00912 1090974004193 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1090974004194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1090974004195 CsbD-like; Region: CsbD; cl17424 1090974004196 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1090974004197 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1090974004198 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1090974004199 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1090974004200 active site 1090974004201 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1090974004202 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1090974004203 putative active site [active] 1090974004204 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1090974004205 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1090974004206 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1090974004207 dimer interface [polypeptide binding]; other site 1090974004208 active site 1090974004209 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1090974004210 dimer interface [polypeptide binding]; other site 1090974004211 active site 1090974004212 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1090974004213 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1090974004214 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1090974004215 active site 1090974004216 phosphorylation site [posttranslational modification] 1090974004217 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1090974004218 active site 1090974004219 active pocket/dimerization site; other site 1090974004220 phosphorylation site [posttranslational modification] 1090974004221 Helix-turn-helix domain; Region: HTH_20; pfam12840 1090974004222 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1090974004223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974004224 Walker A motif; other site 1090974004225 ATP binding site [chemical binding]; other site 1090974004226 Walker B motif; other site 1090974004227 arginine finger; other site 1090974004228 Transcriptional antiterminator [Transcription]; Region: COG3933 1090974004229 PRD domain; Region: PRD; pfam00874 1090974004230 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1090974004231 active pocket/dimerization site; other site 1090974004232 active site 1090974004233 phosphorylation site [posttranslational modification] 1090974004234 PRD domain; Region: PRD; pfam00874 1090974004235 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1090974004236 active site 1090974004237 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1090974004238 substrate binding site [chemical binding]; other site 1090974004239 metal binding site [ion binding]; metal-binding site 1090974004240 Arginine repressor [Transcription]; Region: ArgR; COG1438 1090974004241 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1090974004242 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1090974004243 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1090974004244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974004245 S-adenosylmethionine binding site [chemical binding]; other site 1090974004246 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1090974004247 DltD N-terminal region; Region: DltD_N; pfam04915 1090974004248 DltD central region; Region: DltD_M; pfam04918 1090974004249 DltD C-terminal region; Region: DltD_C; pfam04914 1090974004250 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1090974004251 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1090974004252 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1090974004253 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1090974004254 acyl-activating enzyme (AAE) consensus motif; other site 1090974004255 AMP binding site [chemical binding]; other site 1090974004256 GI:332686128; GI:332686129; putative permease 1090974004257 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974004258 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974004259 Walker A/P-loop; other site 1090974004260 ATP binding site [chemical binding]; other site 1090974004261 Q-loop/lid; other site 1090974004262 ABC transporter signature motif; other site 1090974004263 Walker B; other site 1090974004264 D-loop; other site 1090974004265 H-loop/switch region; other site 1090974004266 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1090974004267 ATP cone domain; Region: ATP-cone; pfam03477 1090974004268 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1090974004269 effector binding site; other site 1090974004270 active site 1090974004271 Zn binding site [ion binding]; other site 1090974004272 glycine loop; other site 1090974004273 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1090974004274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1090974004275 FeS/SAM binding site; other site 1090974004276 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1090974004277 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1090974004278 active site 1090974004279 DNA polymerase IV; Validated; Region: PRK02406 1090974004280 DNA binding site [nucleotide binding] 1090974004281 Predicted methyltransferases [General function prediction only]; Region: COG0313 1090974004282 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1090974004283 putative SAM binding site [chemical binding]; other site 1090974004284 putative homodimer interface [polypeptide binding]; other site 1090974004285 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1090974004286 GI:332686120; signal peptidase-like protein 1090974004287 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1090974004288 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1090974004289 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1090974004290 thymidylate kinase; Validated; Region: tmk; PRK00698 1090974004291 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1090974004292 TMP-binding site; other site 1090974004293 ATP-binding site [chemical binding]; other site 1090974004294 recombination protein RecR; Reviewed; Region: recR; PRK00076 1090974004295 RecR protein; Region: RecR; pfam02132 1090974004296 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1090974004297 putative active site [active] 1090974004298 putative metal-binding site [ion binding]; other site 1090974004299 tetramer interface [polypeptide binding]; other site 1090974004300 hypothetical protein; Validated; Region: PRK00153 1090974004301 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1090974004302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974004303 Walker A motif; other site 1090974004304 ATP binding site [chemical binding]; other site 1090974004305 Walker B motif; other site 1090974004306 arginine finger; other site 1090974004307 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1090974004308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974004309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1090974004310 DNA binding site [nucleotide binding] 1090974004311 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1090974004312 putative ligand binding site [chemical binding]; other site 1090974004313 putative dimerization interface [polypeptide binding]; other site 1090974004314 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1090974004315 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1090974004316 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1090974004317 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1090974004318 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1090974004319 NAD binding site [chemical binding]; other site 1090974004320 homodimer interface [polypeptide binding]; other site 1090974004321 active site 1090974004322 substrate binding site [chemical binding]; other site 1090974004323 galactokinase; Provisional; Region: PRK05322 1090974004324 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1090974004325 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1090974004326 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1090974004327 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1090974004328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1090974004329 active site residue [active] 1090974004330 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1090974004331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1090974004332 nucleotide binding site [chemical binding]; other site 1090974004333 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1090974004334 GI:332686104; GlpG protein 1090974004335 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1090974004336 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1090974004337 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1090974004338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1090974004339 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1090974004340 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1090974004341 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1090974004342 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1090974004343 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1090974004344 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1090974004345 active site 1090974004346 dimer interface [polypeptide binding]; other site 1090974004347 motif 1; other site 1090974004348 motif 2; other site 1090974004349 motif 3; other site 1090974004350 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1090974004351 anticodon binding site; other site 1090974004352 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1090974004353 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1090974004354 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1090974004355 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1090974004356 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1090974004357 putative active site [active] 1090974004358 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1090974004359 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974004360 hypothetical protein; Provisional; Region: PRK12378 1090974004361 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1323 1090974004362 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1090974004363 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1090974004364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1090974004365 S-adenosylmethionine binding site [chemical binding]; other site 1090974004366 Oligomerisation domain; Region: Oligomerisation; cl00519 1090974004367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974004368 Zn2+ binding site [ion binding]; other site 1090974004369 Mg2+ binding site [ion binding]; other site 1090974004370 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1090974004371 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1090974004372 active site 1090974004373 (T/H)XGH motif; other site 1090974004374 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1090974004375 GTPase YqeH; Provisional; Region: PRK13796 1090974004376 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1090974004377 GTP/Mg2+ binding site [chemical binding]; other site 1090974004378 G4 box; other site 1090974004379 G5 box; other site 1090974004380 G1 box; other site 1090974004381 Switch I region; other site 1090974004382 G2 box; other site 1090974004383 G3 box; other site 1090974004384 Switch II region; other site 1090974004385 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1090974004386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974004387 active site 1090974004388 motif I; other site 1090974004389 motif II; other site 1090974004390 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1090974004391 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1090974004392 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1090974004393 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1090974004394 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1090974004395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1090974004396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1090974004397 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1090974004398 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1090974004399 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1090974004400 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1090974004401 carboxyltransferase (CT) interaction site; other site 1090974004402 biotinylation site [posttranslational modification]; other site 1090974004403 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1090974004404 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1090974004405 dimer interface [polypeptide binding]; other site 1090974004406 active site 1090974004407 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1090974004408 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1090974004409 NAD(P) binding site [chemical binding]; other site 1090974004410 homotetramer interface [polypeptide binding]; other site 1090974004411 homodimer interface [polypeptide binding]; other site 1090974004412 active site 1090974004413 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1090974004414 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1090974004415 acyl carrier protein; Provisional; Region: acpP; PRK00982 1090974004416 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1090974004417 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1090974004418 dimer interface [polypeptide binding]; other site 1090974004419 active site 1090974004420 CoA binding pocket [chemical binding]; other site 1090974004421 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1090974004422 MarR family; Region: MarR_2; pfam12802 1090974004423 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1090974004424 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1090974004425 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1090974004426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1090974004427 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1090974004428 putative ADP-binding pocket [chemical binding]; other site 1090974004429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1090974004430 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1090974004431 general stress protein 13; Validated; Region: PRK08059 1090974004432 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1090974004433 RNA binding site [nucleotide binding]; other site 1090974004434 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1090974004435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974004436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974004437 homodimer interface [polypeptide binding]; other site 1090974004438 catalytic residue [active] 1090974004439 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1090974004440 active site 1090974004441 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1090974004442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1090974004443 CAAX protease self-immunity; Region: Abi; pfam02517 1090974004444 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1090974004445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974004446 non-specific DNA binding site [nucleotide binding]; other site 1090974004447 salt bridge; other site 1090974004448 sequence-specific DNA binding site [nucleotide binding]; other site 1090974004449 Virus attachment protein p12 family; Region: P12; pfam12669 1090974004450 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1090974004451 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1090974004452 G1 box; other site 1090974004453 GTP/Mg2+ binding site [chemical binding]; other site 1090974004454 Switch I region; other site 1090974004455 G2 box; other site 1090974004456 G3 box; other site 1090974004457 Switch II region; other site 1090974004458 G4 box; other site 1090974004459 G5 box; other site 1090974004460 Nucleoside recognition; Region: Gate; pfam07670 1090974004461 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1090974004462 Nucleoside recognition; Region: Gate; pfam07670 1090974004463 FeoA domain; Region: FeoA; pfam04023 1090974004464 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1090974004465 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1090974004466 catalytic residues [active] 1090974004467 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1090974004468 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1090974004469 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1090974004470 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1090974004471 active site 1090974004472 dimer interface [polypeptide binding]; other site 1090974004473 catalytic residues [active] 1090974004474 effector binding site; other site 1090974004475 R2 peptide binding site; other site 1090974004476 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1090974004477 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1090974004478 dimer interface [polypeptide binding]; other site 1090974004479 putative radical transfer pathway; other site 1090974004480 diiron center [ion binding]; other site 1090974004481 tyrosyl radical; other site 1090974004482 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1090974004483 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1090974004484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1090974004485 active site 1090974004486 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1090974004487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1090974004488 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1090974004489 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1090974004490 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1090974004491 active site 1090974004492 homodimer interface [polypeptide binding]; other site 1090974004493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974004494 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1090974004495 NAD(P) binding site [chemical binding]; other site 1090974004496 active site 1090974004497 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1090974004498 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1090974004499 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1090974004500 NAD(P) binding site [chemical binding]; other site 1090974004501 homodimer interface [polypeptide binding]; other site 1090974004502 substrate binding site [chemical binding]; other site 1090974004503 active site 1090974004504 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1090974004505 potential frameshift: common BLAST hit: gi|160881625|ref|YP_001560593.1| group 1 glycosyl transferase 1090974004506 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1090974004507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1090974004508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1090974004509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1090974004510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1090974004511 NAD(P) binding site [chemical binding]; other site 1090974004512 active site 1090974004513 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1090974004514 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1090974004515 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1090974004516 NAD(P) binding site [chemical binding]; other site 1090974004517 homodimer interface [polypeptide binding]; other site 1090974004518 substrate binding site [chemical binding]; other site 1090974004519 active site 1090974004520 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1090974004521 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1090974004522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1090974004523 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1090974004524 Chain length determinant protein; Region: Wzz; cl15801 1090974004525 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1090974004526 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1090974004527 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1090974004528 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1090974004529 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1090974004530 D-isomer specific 2-hydroxyacid dehydrogenase family protein; GI:332686028 1090974004531 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1090974004532 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1090974004533 Ligand binding site; other site 1090974004534 Putative Catalytic site; other site 1090974004535 DXD motif; other site 1090974004536 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1090974004537 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1090974004538 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1090974004539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1090974004540 YceG-like family; Region: YceG; pfam02618 1090974004541 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1090974004542 dimerization interface [polypeptide binding]; other site 1090974004543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1090974004544 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1090974004545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1090974004546 nucleotide binding site [chemical binding]; other site 1090974004547 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1090974004548 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1090974004549 active site 1090974004550 metal binding site [ion binding]; metal-binding site 1090974004551 homodimer interface [polypeptide binding]; other site 1090974004552 catalytic site [active] 1090974004553 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1090974004554 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1090974004555 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1090974004556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974004557 DNA-binding site [nucleotide binding]; DNA binding site 1090974004558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974004559 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1090974004560 ligand binding site [chemical binding]; other site 1090974004561 dimerization interface [polypeptide binding]; other site 1090974004562 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1090974004563 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1090974004564 DNA-binding response regulator, AraC family 1090974004565 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1090974004566 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1090974004567 Histidine kinase; Region: His_kinase; pfam06580 1090974004568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1090974004569 Protein of unknown function, DUF624; Region: DUF624; cl02369 1090974004570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974004571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974004572 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1090974004573 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004575 dimer interface [polypeptide binding]; other site 1090974004576 ABC-ATPase subunit interface; other site 1090974004577 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1090974004578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004579 dimer interface [polypeptide binding]; other site 1090974004580 conserved gate region; other site 1090974004581 putative PBP binding loops; other site 1090974004582 ABC-ATPase subunit interface; other site 1090974004583 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1090974004584 substrate binding site [chemical binding]; other site 1090974004585 active site 1090974004586 Predicted transcriptional regulator [Transcription]; Region: COG4189 1090974004587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1090974004588 dimerization interface [polypeptide binding]; other site 1090974004589 putative DNA binding site [nucleotide binding]; other site 1090974004590 putative Zn2+ binding site [ion binding]; other site 1090974004591 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1090974004592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974004593 DNA-binding site [nucleotide binding]; DNA binding site 1090974004594 FCD domain; Region: FCD; pfam07729 1090974004595 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1090974004596 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1090974004597 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1090974004598 altronate oxidoreductase; Provisional; Region: PRK03643 1090974004599 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1090974004600 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1090974004601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974004602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1090974004603 DNA binding site [nucleotide binding] 1090974004604 domain linker motif; other site 1090974004605 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1090974004606 ligand binding site [chemical binding]; other site 1090974004607 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974004608 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1090974004609 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1090974004610 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1090974004611 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974004612 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974004613 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1090974004614 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1090974004615 inhibitor binding site; inhibition site 1090974004616 active site 1090974004617 putative pectinesterase; Region: PLN02432; cl01911 1090974004618 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1090974004619 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1090974004620 Protein of unknown function, DUF624; Region: DUF624; cl02369 1090974004621 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1090974004622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004623 dimer interface [polypeptide binding]; other site 1090974004624 conserved gate region; other site 1090974004625 ABC-ATPase subunit interface; other site 1090974004626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004628 ABC-ATPase subunit interface; other site 1090974004629 potential frameshift: common BLAST hit: gi|332685983|ref|YP_004455757.1| ADA regulatory protein 1090974004630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974004631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1090974004632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974004633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1090974004634 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1090974004635 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1090974004636 active site 1090974004637 catalytic triad [active] 1090974004638 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1090974004639 GI:332685979; amino acid permease family protein 1090974004640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1090974004641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974004642 catalytic residue [active] 1090974004643 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1090974004644 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1090974004645 active site 1090974004646 HIGH motif; other site 1090974004647 dimer interface [polypeptide binding]; other site 1090974004648 KMSKS motif; other site 1090974004649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974004650 RNA binding surface [nucleotide binding]; other site 1090974004651 putative phosphoketolase; Provisional; Region: PRK05261 1090974004652 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1090974004653 TPP-binding site; other site 1090974004654 XFP C-terminal domain; Region: XFP_C; pfam09363 1090974004655 L-arabinose isomerase; Provisional; Region: PRK02929 1090974004656 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1090974004657 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1090974004658 trimer interface [polypeptide binding]; other site 1090974004659 substrate binding site [chemical binding]; other site 1090974004660 Mn binding site [ion binding]; other site 1090974004661 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1090974004662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974004663 putative substrate translocation pore; other site 1090974004664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974004665 Repair protein; Region: Repair_PSII; pfam04536 1090974004666 LemA family; Region: LemA; cl00742 1090974004667 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1090974004668 active site 1090974004669 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1090974004670 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1090974004671 dimer interface [polypeptide binding]; other site 1090974004672 active site 1090974004673 metal binding site [ion binding]; metal-binding site 1090974004674 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1090974004675 putative metal binding site [ion binding]; other site 1090974004676 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1090974004677 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 1090974004678 Ca binding site [ion binding]; other site 1090974004679 potential frameshift: common BLAST hit: gi|332685963|ref|YP_004455737.1| alpha-galactosidase 1090974004680 Melibiase; Region: Melibiase; pfam02065 1090974004681 Melibiase; Region: Melibiase; pfam02065 1090974004682 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974004683 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1090974004684 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1090974004685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974004686 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1090974004687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974004688 FemAB family; Region: FemAB; pfam02388 1090974004689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1090974004690 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1090974004691 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1090974004692 Cl- selectivity filter; other site 1090974004693 Cl- binding residues [ion binding]; other site 1090974004694 pore gating glutamate residue; other site 1090974004695 dimer interface [polypeptide binding]; other site 1090974004696 H+/Cl- coupling transport residue; other site 1090974004697 TrkA-C domain; Region: TrkA_C; pfam02080 1090974004698 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1090974004699 CAT RNA binding domain; Region: CAT_RBD; smart01061 1090974004700 PRD domain; Region: PRD; pfam00874 1090974004701 PRD domain; Region: PRD; pfam00874 1090974004702 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1090974004703 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1090974004704 active site turn [active] 1090974004705 phosphorylation site [posttranslational modification] 1090974004706 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1090974004707 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1090974004708 HPr interaction site; other site 1090974004709 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1090974004710 active site 1090974004711 phosphorylation site [posttranslational modification] 1090974004712 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1090974004713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974004714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974004715 homodimer interface [polypeptide binding]; other site 1090974004716 catalytic residue [active] 1090974004717 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1090974004718 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1090974004719 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1090974004720 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1090974004721 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1090974004722 active site 1090974004723 trimer interface [polypeptide binding]; other site 1090974004724 allosteric site; other site 1090974004725 active site lid [active] 1090974004726 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1090974004727 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1090974004728 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1090974004729 peptide binding site [polypeptide binding]; other site 1090974004730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974004731 non-specific DNA binding site [nucleotide binding]; other site 1090974004732 salt bridge; other site 1090974004733 sequence-specific DNA binding site [nucleotide binding]; other site 1090974004734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1090974004735 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1090974004736 Walker A/P-loop; other site 1090974004737 ATP binding site [chemical binding]; other site 1090974004738 Q-loop/lid; other site 1090974004739 ABC transporter signature motif; other site 1090974004740 Walker B; other site 1090974004741 D-loop; other site 1090974004742 H-loop/switch region; other site 1090974004743 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1090974004744 beta-galactosidase; Region: BGL; TIGR03356 1090974004745 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1090974004746 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1090974004747 active site turn [active] 1090974004748 phosphorylation site [posttranslational modification] 1090974004749 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1090974004750 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1090974004751 HPr interaction site; other site 1090974004752 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1090974004753 active site 1090974004754 phosphorylation site [posttranslational modification] 1090974004755 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1090974004756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974004757 DNA-binding site [nucleotide binding]; DNA binding site 1090974004758 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1090974004759 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1090974004760 active pocket/dimerization site; other site 1090974004761 active site 1090974004762 phosphorylation site [posttranslational modification] 1090974004763 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1090974004764 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1090974004765 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1090974004766 active site 1090974004767 phosphorylation site [posttranslational modification] 1090974004768 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1090974004769 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1090974004770 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1090974004771 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1090974004772 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1090974004773 dimer interface [polypeptide binding]; other site 1090974004774 active site 1090974004775 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1090974004776 putative active site [active] 1090974004777 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1090974004778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1090974004779 DNA-binding site [nucleotide binding]; DNA binding site 1090974004780 UTRA domain; Region: UTRA; pfam07702 1090974004781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974004782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004783 dimer interface [polypeptide binding]; other site 1090974004784 conserved gate region; other site 1090974004785 putative PBP binding loops; other site 1090974004786 ABC-ATPase subunit interface; other site 1090974004787 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1090974004788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974004789 dimer interface [polypeptide binding]; other site 1090974004790 conserved gate region; other site 1090974004791 putative PBP binding loops; other site 1090974004792 ABC-ATPase subunit interface; other site 1090974004793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1090974004794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974004795 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1090974004796 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1090974004797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1090974004798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1090974004799 DNA binding site [nucleotide binding] 1090974004800 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1090974004801 putative ligand binding site [chemical binding]; other site 1090974004802 putative dimerization interface [polypeptide binding]; other site 1090974004803 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1090974004804 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1090974004805 potential frameshift: common BLAST hit: gi|332685909|ref|YP_004455683.1| D-proline reductase, 45 kDa subunit/ D-proline reductase, 23 kDa 1090974004806 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1090974004807 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1090974004808 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1090974004809 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1090974004810 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1090974004811 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1090974004812 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1090974004813 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1090974004814 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1090974004815 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1090974004816 active site 1090974004817 P-loop; other site 1090974004818 phosphorylation site [posttranslational modification] 1090974004819 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1090974004820 active site 1090974004821 dimer interface [polypeptide binding]; other site 1090974004822 catalytic nucleophile [active] 1090974004823 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1090974004824 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 1090974004825 active site 1090974004826 metal binding site [ion binding]; metal-binding site 1090974004827 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1090974004828 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1090974004829 putative dimer interface [polypeptide binding]; other site 1090974004830 putative anticodon binding site; other site 1090974004831 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1090974004832 homodimer interface [polypeptide binding]; other site 1090974004833 motif 1; other site 1090974004834 motif 2; other site 1090974004835 active site 1090974004836 motif 3; other site 1090974004837 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1090974004838 GI:332685893; xylulose kinase 1090974004839 xylose isomerase; Provisional; Region: PRK05474 1090974004840 xylose isomerase; Region: xylose_isom_A; TIGR02630 1090974004841 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1090974004842 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1090974004843 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1090974004844 nucleotide binding site [chemical binding]; other site 1090974004845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1090974004846 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974004847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974004848 Walker A/P-loop; other site 1090974004849 ATP binding site [chemical binding]; other site 1090974004850 Q-loop/lid; other site 1090974004851 ABC transporter signature motif; other site 1090974004852 Walker B; other site 1090974004853 D-loop; other site 1090974004854 H-loop/switch region; other site 1090974004855 Class I aldolases; Region: Aldolase_Class_I; cl17187 1090974004856 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1090974004857 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1090974004858 putative substrate binding site [chemical binding]; other site 1090974004859 putative ATP binding site [chemical binding]; other site 1090974004860 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1090974004861 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1090974004862 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1090974004863 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1090974004864 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1090974004865 GI:332685883; integral membrane protein 1090974004866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974004867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974004868 Walker A/P-loop; other site 1090974004869 ATP binding site [chemical binding]; other site 1090974004870 Q-loop/lid; other site 1090974004871 ABC transporter signature motif; other site 1090974004872 Walker B; other site 1090974004873 D-loop; other site 1090974004874 H-loop/switch region; other site 1090974004875 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1090974004876 GI:332685880; dipeptidase 1090974004877 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1090974004878 MgtC family; Region: MgtC; pfam02308 1090974004879 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1090974004880 active site 1090974004881 catalytic triad [active] 1090974004882 oxyanion hole [active] 1090974004883 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 1090974004884 active site 1090974004885 catalytic site [active] 1090974004886 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 1090974004887 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 1090974004888 Ca binding site [ion binding]; other site 1090974004889 substrate binding site [chemical binding]; other site 1090974004890 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974004891 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1090974004892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974004893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974004894 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1090974004895 Walker A/P-loop; other site 1090974004896 ATP binding site [chemical binding]; other site 1090974004897 Q-loop/lid; other site 1090974004898 ABC transporter signature motif; other site 1090974004899 Walker B; other site 1090974004900 D-loop; other site 1090974004901 H-loop/switch region; other site 1090974004902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974004903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974004904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974004905 Walker A/P-loop; other site 1090974004906 ATP binding site [chemical binding]; other site 1090974004907 Q-loop/lid; other site 1090974004908 ABC transporter signature motif; other site 1090974004909 Walker B; other site 1090974004910 D-loop; other site 1090974004911 H-loop/switch region; other site 1090974004912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1090974004913 MarR family; Region: MarR_2; pfam12802 1090974004914 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1090974004915 active site 1090974004916 tetramer interface [polypeptide binding]; other site 1090974004917 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1090974004918 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1090974004919 Nucleoside recognition; Region: Gate; pfam07670 1090974004920 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1090974004921 Domain of unknown function (DUF718); Region: DUF718; cl01281 1090974004922 Helix-turn-helix domain; Region: HTH_18; pfam12833 1090974004923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974004924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1090974004925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1090974004926 active site 1090974004927 catalytic tetrad [active] 1090974004928 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1090974004929 HPr interaction site; other site 1090974004930 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1090974004931 active site 1090974004932 phosphorylation site [posttranslational modification] 1090974004933 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1090974004934 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1090974004935 substrate binding site [chemical binding]; other site 1090974004936 dimer interface [polypeptide binding]; other site 1090974004937 ATP binding site [chemical binding]; other site 1090974004938 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1090974004939 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1090974004940 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1090974004941 putative active site [active] 1090974004942 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1090974004943 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1090974004944 active site turn [active] 1090974004945 phosphorylation site [posttranslational modification] 1090974004946 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1090974004947 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1090974004948 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1090974004949 putative active site [active] 1090974004950 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1090974004951 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1090974004952 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1090974004953 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1090974004954 active site 1090974004955 P-loop; other site 1090974004956 phosphorylation site [posttranslational modification] 1090974004957 Mga helix-turn-helix domain; Region: Mga; pfam05043 1090974004958 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1090974004959 PRD domain; Region: PRD; pfam00874 1090974004960 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1090974004961 active site 1090974004962 P-loop; other site 1090974004963 phosphorylation site [posttranslational modification] 1090974004964 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1090974004965 active site 1090974004966 phosphorylation site [posttranslational modification] 1090974004967 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1090974004968 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1090974004969 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1090974004970 protein binding site [polypeptide binding]; other site 1090974004971 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1090974004972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1090974004973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1090974004974 rod shape-determining protein MreC; Provisional; Region: PRK13922 1090974004975 rod shape-determining protein MreC; Region: MreC; pfam04085 1090974004976 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1090974004977 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1090974004978 RNase E interface [polypeptide binding]; other site 1090974004979 trimer interface [polypeptide binding]; other site 1090974004980 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1090974004981 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1090974004982 RNase E interface [polypeptide binding]; other site 1090974004983 trimer interface [polypeptide binding]; other site 1090974004984 active site 1090974004985 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1090974004986 putative nucleic acid binding region [nucleotide binding]; other site 1090974004987 G-X-X-G motif; other site 1090974004988 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1090974004989 RNA binding site [nucleotide binding]; other site 1090974004990 domain interface; other site 1090974004991 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1090974004992 16S/18S rRNA binding site [nucleotide binding]; other site 1090974004993 S13e-L30e interaction site [polypeptide binding]; other site 1090974004994 25S rRNA binding site [nucleotide binding]; other site 1090974004995 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1090974004996 active site 1090974004997 catalytic residues [active] 1090974004998 metal binding site [ion binding]; metal-binding site 1090974004999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974005000 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1090974005001 active site 1090974005002 motif I; other site 1090974005003 motif II; other site 1090974005004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974005005 GI:332685836; formate/nitrite transporter family protein 1090974005006 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1090974005007 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1090974005008 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1090974005009 RNA binding surface [nucleotide binding]; other site 1090974005010 BioY family; Region: BioY; pfam02632 1090974005011 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1090974005012 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1090974005013 putative ligand binding residues [chemical binding]; other site 1090974005014 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1090974005015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1090974005016 Walker A/P-loop; other site 1090974005017 ATP binding site [chemical binding]; other site 1090974005018 Q-loop/lid; other site 1090974005019 ABC transporter signature motif; other site 1090974005020 Walker B; other site 1090974005021 D-loop; other site 1090974005022 H-loop/switch region; other site 1090974005023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974005024 ABC-ATPase subunit interface; other site 1090974005025 dimer interface [polypeptide binding]; other site 1090974005026 putative PBP binding regions; other site 1090974005027 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1090974005028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1090974005029 ABC-ATPase subunit interface; other site 1090974005030 dimer interface [polypeptide binding]; other site 1090974005031 putative PBP binding regions; other site 1090974005032 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1090974005033 GI:332685827; tRNA-dependent lipid II-Ala--L-alanine ligase 1090974005034 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1090974005035 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1090974005036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1090974005037 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1090974005038 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1090974005039 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1090974005040 P loop; other site 1090974005041 GTP binding site [chemical binding]; other site 1090974005042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974005043 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1090974005044 active site 1090974005045 motif I; other site 1090974005046 motif II; other site 1090974005047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974005048 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1090974005049 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1090974005050 Walker A/P-loop; other site 1090974005051 ATP binding site [chemical binding]; other site 1090974005052 Q-loop/lid; other site 1090974005053 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1090974005054 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1090974005055 ABC transporter signature motif; other site 1090974005056 Walker B; other site 1090974005057 D-loop; other site 1090974005058 H-loop/switch region; other site 1090974005059 ribonuclease III; Reviewed; Region: rnc; PRK00102 1090974005060 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1090974005061 dimerization interface [polypeptide binding]; other site 1090974005062 active site 1090974005063 metal binding site [ion binding]; metal-binding site 1090974005064 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1090974005065 dsRNA binding site [nucleotide binding]; other site 1090974005066 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1090974005067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974005068 Walker A motif; other site 1090974005069 ATP binding site [chemical binding]; other site 1090974005070 Walker B motif; other site 1090974005071 arginine finger; other site 1090974005072 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1090974005073 GI:332685820; Holliday junction DNA helicase RuvA 1090974005074 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1090974005075 SelR domain; Region: SelR; pfam01641 1090974005076 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1090974005077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974005078 ATP binding site [chemical binding]; other site 1090974005079 Mg2+ binding site [ion binding]; other site 1090974005080 G-X-G motif; other site 1090974005081 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1090974005082 ATP binding site [chemical binding]; other site 1090974005083 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1090974005084 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1090974005085 MutS domain I; Region: MutS_I; pfam01624 1090974005086 MutS domain II; Region: MutS_II; pfam05188 1090974005087 MutS domain III; Region: MutS_III; pfam05192 1090974005088 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1090974005089 Walker A/P-loop; other site 1090974005090 ATP binding site [chemical binding]; other site 1090974005091 Q-loop/lid; other site 1090974005092 ABC transporter signature motif; other site 1090974005093 Walker B; other site 1090974005094 D-loop; other site 1090974005095 H-loop/switch region; other site 1090974005096 Protein of unknown function (DUF964); Region: DUF964; cl01483 1090974005097 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1090974005098 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1090974005099 putative active site [active] 1090974005100 metal binding site [ion binding]; metal-binding site 1090974005101 homodimer binding site [polypeptide binding]; other site 1090974005102 phosphodiesterase; Provisional; Region: PRK12704 1090974005103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1090974005104 Zn2+ binding site [ion binding]; other site 1090974005105 Mg2+ binding site [ion binding]; other site 1090974005106 recombinase A; Provisional; Region: recA; PRK09354 1090974005107 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1090974005108 hexamer interface [polypeptide binding]; other site 1090974005109 Walker A motif; other site 1090974005110 ATP binding site [chemical binding]; other site 1090974005111 Walker B motif; other site 1090974005112 competence damage-inducible protein A; Provisional; Region: PRK00549 1090974005113 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1090974005114 putative MPT binding site; other site 1090974005115 Competence-damaged protein; Region: CinA; pfam02464 1090974005116 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1090974005117 Peptidase family U32; Region: Peptidase_U32; pfam01136 1090974005118 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1090974005119 Peptidase family U32; Region: Peptidase_U32; pfam01136 1090974005120 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1090974005121 Clp amino terminal domain; Region: Clp_N; pfam02861 1090974005122 Clp amino terminal domain; Region: Clp_N; pfam02861 1090974005123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974005124 Walker A motif; other site 1090974005125 ATP binding site [chemical binding]; other site 1090974005126 Walker B motif; other site 1090974005127 arginine finger; other site 1090974005128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1090974005129 Walker A motif; other site 1090974005130 ATP binding site [chemical binding]; other site 1090974005131 Walker B motif; other site 1090974005132 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1090974005133 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1090974005134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974005135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974005136 active site 1090974005137 phosphorylation site [posttranslational modification] 1090974005138 intermolecular recognition site; other site 1090974005139 dimerization interface [polypeptide binding]; other site 1090974005140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974005141 DNA binding site [nucleotide binding] 1090974005142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974005143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974005144 dimer interface [polypeptide binding]; other site 1090974005145 phosphorylation site [posttranslational modification] 1090974005146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974005147 ATP binding site [chemical binding]; other site 1090974005148 Mg2+ binding site [ion binding]; other site 1090974005149 G-X-G motif; other site 1090974005150 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1090974005151 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1090974005152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1090974005153 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1090974005154 active site 1090974005155 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1090974005156 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1090974005157 GTP-binding protein YchF; Reviewed; Region: PRK09601 1090974005158 YchF GTPase; Region: YchF; cd01900 1090974005159 G1 box; other site 1090974005160 GTP/Mg2+ binding site [chemical binding]; other site 1090974005161 Switch I region; other site 1090974005162 G2 box; other site 1090974005163 Switch II region; other site 1090974005164 G3 box; other site 1090974005165 G4 box; other site 1090974005166 G5 box; other site 1090974005167 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1090974005168 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1090974005169 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1090974005170 ParB-like nuclease domain; Region: ParBc; pfam02195 1090974005171 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1090974005172 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1090974005173 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1090974005174 Magnesium ion binding site [ion binding]; other site 1090974005175 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1090974005176 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1090974005177 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1090974005178 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1090974005179 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1090974005180 Nucleoside recognition; Region: Gate; pfam07670 1090974005181 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1090974005182 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1090974005183 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1090974005184 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1090974005185 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1090974005186 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1090974005187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1090974005188 DNA binding residues [nucleotide binding] 1090974005189 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1090974005190 phosphopentomutase; Provisional; Region: PRK05362 1090974005191 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1090974005192 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1090974005193 intersubunit interface [polypeptide binding]; other site 1090974005194 active site 1090974005195 catalytic residue [active] 1090974005196 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1090974005197 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1090974005198 active site 1090974005199 catalytic residue [active] 1090974005200 dimer interface [polypeptide binding]; other site 1090974005201 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1090974005202 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1090974005203 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974005204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974005205 Walker A/P-loop; other site 1090974005206 ATP binding site [chemical binding]; other site 1090974005207 Q-loop/lid; other site 1090974005208 ABC transporter signature motif; other site 1090974005209 Walker B; other site 1090974005210 D-loop; other site 1090974005211 H-loop/switch region; other site 1090974005212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1090974005213 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1090974005214 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1090974005215 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1090974005216 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1090974005217 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1090974005218 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1090974005219 G1 box; other site 1090974005220 GTP/Mg2+ binding site [chemical binding]; other site 1090974005221 Switch I region; other site 1090974005222 G2 box; other site 1090974005223 Switch II region; other site 1090974005224 G3 box; other site 1090974005225 G4 box; other site 1090974005226 G5 box; other site 1090974005227 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1090974005228 potential frameshift: common BLAST hit: gi|332687271|ref|YP_004457045.1| cell wall-associated protease 1090974005229 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1090974005230 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1090974005231 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1090974005232 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1090974005233 G-X-X-G motif; other site 1090974005234 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1090974005235 RxxxH motif; other site 1090974005236 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1090974005237 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1090974005238 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1090974005239 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1090974005240 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1090974005241 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1090974005242 P-loop; other site 1090974005243 Magnesium ion binding site [ion binding]; other site 1090974005244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1090974005245 Magnesium ion binding site [ion binding]; other site 1090974005246 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974005247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974005248 Walker A/P-loop; other site 1090974005249 ATP binding site [chemical binding]; other site 1090974005250 Q-loop/lid; other site 1090974005251 ABC transporter signature motif; other site 1090974005252 Walker B; other site 1090974005253 D-loop; other site 1090974005254 H-loop/switch region; other site 1090974005255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974005256 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1090974005257 Walker A/P-loop; other site 1090974005258 ATP binding site [chemical binding]; other site 1090974005259 Q-loop/lid; other site 1090974005260 ABC transporter signature motif; other site 1090974005261 Walker B; other site 1090974005262 D-loop; other site 1090974005263 H-loop/switch region; other site 1090974005264 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1090974005265 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1090974005266 active site 1090974005267 ATP binding site [chemical binding]; other site 1090974005268 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1090974005269 active site 1090974005270 zinc binding site [ion binding]; other site 1090974005271 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1090974005272 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1090974005273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974005274 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974005275 Walker A/P-loop; other site 1090974005276 ATP binding site [chemical binding]; other site 1090974005277 Q-loop/lid; other site 1090974005278 ABC transporter signature motif; other site 1090974005279 Walker B; other site 1090974005280 D-loop; other site 1090974005281 H-loop/switch region; other site 1090974005282 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1090974005283 GI:332687293 1090974005284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974005285 sequence-specific DNA binding site [nucleotide binding]; other site 1090974005286 salt bridge; other site 1090974005287 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1090974005288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1090974005289 non-specific DNA binding site [nucleotide binding]; other site 1090974005290 salt bridge; other site 1090974005291 sequence-specific DNA binding site [nucleotide binding]; other site 1090974005292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974005293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1090974005294 Walker A/P-loop; other site 1090974005295 ATP binding site [chemical binding]; other site 1090974005296 Q-loop/lid; other site 1090974005297 ABC transporter signature motif; other site 1090974005298 Walker B; other site 1090974005299 D-loop; other site 1090974005300 H-loop/switch region; other site 1090974005301 GI:332687302; GO:0005524 1090974005302 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1090974005303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1090974005304 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1090974005305 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1090974005306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1090974005307 Walker A/P-loop; other site 1090974005308 ATP binding site [chemical binding]; other site 1090974005309 Q-loop/lid; other site 1090974005310 ABC transporter signature motif; other site 1090974005311 Walker B; other site 1090974005312 D-loop; other site 1090974005313 H-loop/switch region; other site 1090974005314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1090974005315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1090974005316 active site 1090974005317 phosphorylation site [posttranslational modification] 1090974005318 intermolecular recognition site; other site 1090974005319 dimerization interface [polypeptide binding]; other site 1090974005320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1090974005321 DNA binding site [nucleotide binding] 1090974005322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1090974005323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1090974005324 dimer interface [polypeptide binding]; other site 1090974005325 phosphorylation site [posttranslational modification] 1090974005326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1090974005327 ATP binding site [chemical binding]; other site 1090974005328 Mg2+ binding site [ion binding]; other site 1090974005329 G-X-G motif; other site 1090974005330 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1090974005331 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1090974005332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1090974005333 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1090974005334 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1090974005335 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1090974005336 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1090974005337 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1090974005338 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1090974005339 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1090974005340 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1090974005341 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1090974005342 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1090974005344 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1090974005345 inhibitor binding site; inhibition site 1090974005346 active site 1090974005347 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1090974005348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1090974005349 motif II; other site 1090974005350 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1090974005351 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1090974005352 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1090974005353 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1090974005354 Cupin domain; Region: Cupin_2; cl17218 1090974005355 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1090974005356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1090974005357 Predicted transcriptional regulators [Transcription]; Region: COG1695 1090974005358 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1090974005359 Predicted membrane protein [Function unknown]; Region: COG4709 1090974005360 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1090974005361 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 1090974005362 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1090974005363 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1090974005364 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1090974005365 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1090974005366 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1090974005367 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1090974005368 beta-galactosidase; Region: BGL; TIGR03356 1090974005369 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1090974005370 MarR family; Region: MarR_2; pfam12802 1090974005371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1090974005372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1090974005373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1090974005374 Walker A/P-loop; other site 1090974005375 ATP binding site [chemical binding]; other site 1090974005376 Q-loop/lid; other site 1090974005377 ABC transporter signature motif; other site 1090974005378 Walker B; other site 1090974005379 D-loop; other site 1090974005380 H-loop/switch region; other site 1090974005381 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1090974005382 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1090974005383 putative active site [active] 1090974005384 putative FMN binding site [chemical binding]; other site 1090974005385 putative substrate binding site [chemical binding]; other site 1090974005386 putative catalytic residue [active] 1090974005387 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974005388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974005389 putative substrate translocation pore; other site 1090974005390 legume lectins; Region: lectin_L-type; cd01951 1090974005391 carbohydrate binding site [chemical binding]; other site 1090974005392 metal binding site [ion binding]; metal-binding site 1090974005393 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005394 domain interaction interfaces [polypeptide binding]; other site 1090974005395 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005396 domain interaction interfaces [polypeptide binding]; other site 1090974005397 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005398 domain interaction interfaces [polypeptide binding]; other site 1090974005399 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005400 domain interaction interfaces [polypeptide binding]; other site 1090974005401 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005402 domain interaction interfaces [polypeptide binding]; other site 1090974005403 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005404 domain interaction interfaces [polypeptide binding]; other site 1090974005405 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005406 domain interaction interfaces [polypeptide binding]; other site 1090974005407 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005408 domain interaction interfaces [polypeptide binding]; other site 1090974005409 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005410 domain interaction interfaces [polypeptide binding]; other site 1090974005411 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1090974005412 domain interaction interfaces [polypeptide binding]; other site 1090974005413 CAT RNA binding domain; Region: CAT_RBD; smart01061 1090974005414 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1090974005415 PRD domain; Region: PRD; pfam00874 1090974005416 PRD domain; Region: PRD; pfam00874 1090974005417 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1090974005418 beta-galactosidase; Region: BGL; TIGR03356 1090974005419 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1090974005420 methionine cluster; other site 1090974005421 active site 1090974005422 phosphorylation site [posttranslational modification] 1090974005423 metal binding site [ion binding]; metal-binding site 1090974005424 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1090974005425 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1090974005426 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1090974005427 active site 1090974005428 P-loop; other site 1090974005429 phosphorylation site [posttranslational modification] 1090974005430 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1090974005431 active site 1090974005432 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1090974005433 Predicted membrane protein [Function unknown]; Region: COG2323 1090974005434 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1090974005435 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1090974005436 dimer interface [polypeptide binding]; other site 1090974005437 active site 1090974005438 putative acyltransferase; Provisional; Region: PRK05790 1090974005439 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1090974005440 dimer interface [polypeptide binding]; other site 1090974005441 active site 1090974005442 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1090974005443 homodimer interface [polypeptide binding]; other site 1090974005444 catalytic residues [active] 1090974005445 NAD binding site [chemical binding]; other site 1090974005446 substrate binding pocket [chemical binding]; other site 1090974005447 flexible flap; other site 1090974005448 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1090974005449 Predicted membrane protein [Function unknown]; Region: COG3817 1090974005450 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1090974005451 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1090974005452 putative substrate binding pocket [chemical binding]; other site 1090974005453 AC domain interface; other site 1090974005454 catalytic triad [active] 1090974005455 AB domain interface; other site 1090974005456 interchain disulfide; other site 1090974005457 FtsX-like permease family; Region: FtsX; pfam02687 1090974005458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974005459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974005460 Walker A/P-loop; other site 1090974005461 ATP binding site [chemical binding]; other site 1090974005462 Q-loop/lid; other site 1090974005463 ABC transporter signature motif; other site 1090974005464 Walker B; other site 1090974005465 D-loop; other site 1090974005466 H-loop/switch region; other site 1090974005467 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974005468 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974005469 Walker A/P-loop; other site 1090974005470 ATP binding site [chemical binding]; other site 1090974005471 Q-loop/lid; other site 1090974005472 ABC transporter signature motif; other site 1090974005473 Walker B; other site 1090974005474 D-loop; other site 1090974005475 H-loop/switch region; other site 1090974005476 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1090974005477 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1090974005478 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1090974005479 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1090974005480 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1090974005481 Glucuronate isomerase; Region: UxaC; pfam02614 1090974005482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1090974005483 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1090974005484 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974005486 dimer interface [polypeptide binding]; other site 1090974005487 conserved gate region; other site 1090974005488 ABC-ATPase subunit interface; other site 1090974005489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974005491 dimer interface [polypeptide binding]; other site 1090974005492 conserved gate region; other site 1090974005493 putative PBP binding loops; other site 1090974005494 ABC-ATPase subunit interface; other site 1090974005495 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1090974005496 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974005497 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1090974005498 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974005499 Protein of unknown function (DUF1686); Region: DUF1686; pfam07937 1090974005500 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1090974005501 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1090974005502 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1090974005503 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1090974005504 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1090974005505 seryl-tRNA synthetase; Provisional; Region: PRK05431 1090974005506 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1090974005507 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1090974005508 dimer interface [polypeptide binding]; other site 1090974005509 active site 1090974005510 motif 1; other site 1090974005511 motif 2; other site 1090974005512 motif 3; other site 1090974005513 seryl-tRNA synthetase; Provisional; Region: PRK05431 1090974005514 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1090974005515 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1090974005516 dimer interface [polypeptide binding]; other site 1090974005517 active site 1090974005518 motif 1; other site 1090974005519 motif 2; other site 1090974005520 motif 3; other site 1090974005521 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1090974005522 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1090974005523 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1090974005524 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1090974005525 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1090974005526 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1090974005527 Protein of unknown function (DUF1686); Region: DUF1686; pfam07937 1090974005528 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1090974005529 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974005530 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974005531 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1090974005532 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1090974005533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974005534 dimer interface [polypeptide binding]; other site 1090974005535 conserved gate region; other site 1090974005536 putative PBP binding loops; other site 1090974005537 ABC-ATPase subunit interface; other site 1090974005538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1090974005539 dimer interface [polypeptide binding]; other site 1090974005540 conserved gate region; other site 1090974005541 ABC-ATPase subunit interface; other site 1090974005542 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1090974005543 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1090974005544 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1090974005545 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1090974005546 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1090974005547 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1090974005548 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1090974005549 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1090974005550 manganese transport protein MntH; Reviewed; Region: PRK00701 1090974005551 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1090974005552 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1090974005553 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1090974005554 Walker A/P-loop; other site 1090974005555 ATP binding site [chemical binding]; other site 1090974005556 Q-loop/lid; other site 1090974005557 ABC transporter signature motif; other site 1090974005558 Walker B; other site 1090974005559 D-loop; other site 1090974005560 H-loop/switch region; other site 1090974005561 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1090974005562 FtsX-like permease family; Region: FtsX; pfam02687 1090974005563 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1090974005564 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 1090974005565 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1090974005566 Coenzyme A transferase; Region: CoA_trans; cl17247 1090974005567 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1090974005568 citrate lyase subunit gamma; Provisional; Region: PRK13253 1090974005569 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 1090974005570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1090974005571 active site 1090974005572 nucleotide binding site [chemical binding]; other site 1090974005573 HIGH motif; other site 1090974005574 KMSKS motif; other site 1090974005575 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1090974005576 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1090974005577 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1090974005578 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1090974005579 putative NAD(P) binding site [chemical binding]; other site 1090974005580 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1090974005581 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1090974005582 Predicted transcriptional regulator [Transcription]; Region: COG1959 1090974005583 Transcriptional regulator; Region: Rrf2; pfam02082 1090974005584 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1090974005585 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1090974005586 galactoside permease; Reviewed; Region: lacY; PRK09528 1090974005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974005588 putative substrate translocation pore; other site 1090974005589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974005590 galactoside permease; Reviewed; Region: lacY; PRK09528 1090974005591 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1090974005592 active site 1090974005593 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1090974005594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1090974005595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1090974005596 homodimer interface [polypeptide binding]; other site 1090974005597 catalytic residue [active] 1090974005598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1090974005599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1090974005600 catalytic residue [active] 1090974005601 Viral enhancin protein; Region: Enhancin; pfam03272 1090974005602 Peptidase M60-like family; Region: M60-like; pfam13402 1090974005603 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1090974005604 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1090974005605 Right handed beta helix region; Region: Beta_helix; pfam13229 1090974005606 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1090974005607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1090974005608 putative substrate translocation pore; other site 1090974005609 Replicase family; Region: Replicase; pfam03090 1090974005610 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708