-- dump date 20140619_140754 -- class Genbank::misc_feature -- table misc_feature_note -- id note 754035000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 754035000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 754035000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754035000004 Walker A motif; other site 754035000005 ATP binding site [chemical binding]; other site 754035000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 754035000007 DnaA box-binding interface [nucleotide binding]; other site 754035000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 754035000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 754035000010 putative DNA binding surface [nucleotide binding]; other site 754035000011 dimer interface [polypeptide binding]; other site 754035000012 beta-clamp/clamp loader binding surface; other site 754035000013 beta-clamp/translesion DNA polymerase binding surface; other site 754035000014 recombination protein F; Reviewed; Region: recF; PRK00064 754035000015 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 754035000016 Walker A/P-loop; other site 754035000017 ATP binding site [chemical binding]; other site 754035000018 Q-loop/lid; other site 754035000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035000020 ABC transporter signature motif; other site 754035000021 Walker B; other site 754035000022 D-loop; other site 754035000023 H-loop/switch region; other site 754035000024 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 754035000025 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 754035000026 ATP binding site [chemical binding]; other site 754035000027 substrate interface [chemical binding]; other site 754035000028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035000029 Coenzyme A binding pocket [chemical binding]; other site 754035000030 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754035000031 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 754035000032 dimerization interface [polypeptide binding]; other site 754035000033 ligand binding site [chemical binding]; other site 754035000034 NADP binding site [chemical binding]; other site 754035000035 catalytic site [active] 754035000036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 754035000037 Bacterial SH3 domain; Region: SH3_4; pfam06347 754035000038 Bacterial SH3 domain; Region: SH3_4; pfam06347 754035000039 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 754035000040 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754035000041 metal binding site 2 [ion binding]; metal-binding site 754035000042 putative DNA binding helix; other site 754035000043 metal binding site 1 [ion binding]; metal-binding site 754035000044 dimer interface [polypeptide binding]; other site 754035000045 structural Zn2+ binding site [ion binding]; other site 754035000046 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 754035000047 active site 1 [active] 754035000048 dimer interface [polypeptide binding]; other site 754035000049 active site 2 [active] 754035000050 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 754035000051 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035000052 dimer interface [polypeptide binding]; other site 754035000053 active site 754035000054 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 754035000055 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 754035000056 NAD binding site [chemical binding]; other site 754035000057 homotetramer interface [polypeptide binding]; other site 754035000058 homodimer interface [polypeptide binding]; other site 754035000059 substrate binding site [chemical binding]; other site 754035000060 active site 754035000061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035000062 metal binding site [ion binding]; metal-binding site 754035000063 active site 754035000064 I-site; other site 754035000065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035000066 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 754035000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035000068 S-adenosylmethionine binding site [chemical binding]; other site 754035000069 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 754035000070 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 754035000071 RNase E interface [polypeptide binding]; other site 754035000072 trimer interface [polypeptide binding]; other site 754035000073 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 754035000074 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 754035000075 RNase E interface [polypeptide binding]; other site 754035000076 trimer interface [polypeptide binding]; other site 754035000077 active site 754035000078 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 754035000079 putative nucleic acid binding region [nucleotide binding]; other site 754035000080 G-X-X-G motif; other site 754035000081 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 754035000082 RNA binding site [nucleotide binding]; other site 754035000083 domain interface; other site 754035000084 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 754035000085 16S/18S rRNA binding site [nucleotide binding]; other site 754035000086 S13e-L30e interaction site [polypeptide binding]; other site 754035000087 25S rRNA binding site [nucleotide binding]; other site 754035000088 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 754035000089 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 754035000090 oligomer interface [polypeptide binding]; other site 754035000091 metal binding site [ion binding]; metal-binding site 754035000092 metal binding site [ion binding]; metal-binding site 754035000093 Cl binding site [ion binding]; other site 754035000094 aspartate ring; other site 754035000095 basic sphincter; other site 754035000096 putative hydrophobic gate; other site 754035000097 periplasmic entrance; other site 754035000098 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 754035000099 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 754035000100 RNA binding site [nucleotide binding]; other site 754035000101 active site 754035000102 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 754035000103 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 754035000104 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 754035000105 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754035000106 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 754035000107 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 754035000108 G1 box; other site 754035000109 putative GEF interaction site [polypeptide binding]; other site 754035000110 GTP/Mg2+ binding site [chemical binding]; other site 754035000111 Switch I region; other site 754035000112 G2 box; other site 754035000113 G3 box; other site 754035000114 Switch II region; other site 754035000115 G4 box; other site 754035000116 G5 box; other site 754035000117 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 754035000118 Translation-initiation factor 2; Region: IF-2; pfam11987 754035000119 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 754035000120 hypothetical protein; Provisional; Region: PRK09190 754035000121 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 754035000122 putative RNA binding cleft [nucleotide binding]; other site 754035000123 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 754035000124 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 754035000125 NusA N-terminal domain; Region: NusA_N; pfam08529 754035000126 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 754035000127 RNA binding site [nucleotide binding]; other site 754035000128 homodimer interface [polypeptide binding]; other site 754035000129 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 754035000130 G-X-X-G motif; other site 754035000131 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 754035000132 G-X-X-G motif; other site 754035000133 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 754035000134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 754035000135 Sm and related proteins; Region: Sm_like; cl00259 754035000136 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 754035000137 putative oligomer interface [polypeptide binding]; other site 754035000138 putative RNA binding site [nucleotide binding]; other site 754035000139 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 754035000140 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 754035000141 S-adenosylmethionine synthetase; Validated; Region: PRK05250 754035000142 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 754035000143 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 754035000144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035000145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035000146 non-specific DNA binding site [nucleotide binding]; other site 754035000147 salt bridge; other site 754035000148 sequence-specific DNA binding site [nucleotide binding]; other site 754035000149 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 754035000150 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 754035000151 putative active site [active] 754035000152 catalytic triad [active] 754035000153 putative dimer interface [polypeptide binding]; other site 754035000154 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 754035000155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035000156 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754035000157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754035000158 Transporter associated domain; Region: CorC_HlyC; smart01091 754035000159 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 754035000160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 754035000161 PhoH-like protein; Region: PhoH; pfam02562 754035000162 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 754035000163 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754035000164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035000165 FeS/SAM binding site; other site 754035000166 TRAM domain; Region: TRAM; pfam01938 754035000167 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754035000168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754035000169 putative acyl-acceptor binding pocket; other site 754035000170 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035000171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035000172 Coenzyme A binding pocket [chemical binding]; other site 754035000173 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 754035000174 Glycoprotease family; Region: Peptidase_M22; pfam00814 754035000175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 754035000176 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 754035000177 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 754035000178 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 754035000179 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 754035000180 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 754035000181 heme binding site [chemical binding]; other site 754035000182 ferroxidase pore; other site 754035000183 ferroxidase diiron center [ion binding]; other site 754035000184 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 754035000185 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 754035000186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035000187 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 754035000188 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 754035000189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035000190 inhibitor-cofactor binding pocket; inhibition site 754035000191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035000192 catalytic residue [active] 754035000193 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035000194 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035000195 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035000196 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035000197 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035000198 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035000199 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035000200 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035000201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000202 Walker A/P-loop; other site 754035000203 ATP binding site [chemical binding]; other site 754035000204 Q-loop/lid; other site 754035000205 ABC transporter signature motif; other site 754035000206 Walker B; other site 754035000207 D-loop; other site 754035000208 H-loop/switch region; other site 754035000209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035000210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000211 Walker A/P-loop; other site 754035000212 ATP binding site [chemical binding]; other site 754035000213 Q-loop/lid; other site 754035000214 ABC transporter signature motif; other site 754035000215 Walker B; other site 754035000216 D-loop; other site 754035000217 H-loop/switch region; other site 754035000218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000219 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754035000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000221 ABC-ATPase subunit interface; other site 754035000222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000224 dimer interface [polypeptide binding]; other site 754035000225 conserved gate region; other site 754035000226 putative PBP binding loops; other site 754035000227 ABC-ATPase subunit interface; other site 754035000228 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035000229 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 754035000230 lytic murein transglycosylase; Region: MltB_2; TIGR02283 754035000231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035000232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035000233 catalytic residue [active] 754035000234 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035000235 recombination protein RecR; Reviewed; Region: recR; PRK00076 754035000236 RecR protein; Region: RecR; pfam02132 754035000237 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 754035000238 putative active site [active] 754035000239 putative metal-binding site [ion binding]; other site 754035000240 tetramer interface [polypeptide binding]; other site 754035000241 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 754035000242 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 754035000243 hypothetical protein; Validated; Region: PRK00153 754035000244 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 754035000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035000246 Walker A motif; other site 754035000247 ATP binding site [chemical binding]; other site 754035000248 Walker B motif; other site 754035000249 arginine finger; other site 754035000250 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 754035000251 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 754035000252 HIT domain; Region: HIT; pfam01230 754035000253 nucleotide binding site/active site [active] 754035000254 HIT family signature motif; other site 754035000255 catalytic residue [active] 754035000256 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 754035000257 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 754035000258 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 754035000259 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 754035000260 putative NADH binding site [chemical binding]; other site 754035000261 putative active site [active] 754035000262 nudix motif; other site 754035000263 putative metal binding site [ion binding]; other site 754035000264 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 754035000265 prephenate dehydratase; Provisional; Region: PRK11899 754035000266 Prephenate dehydratase; Region: PDT; pfam00800 754035000267 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 754035000268 putative L-Phe binding site [chemical binding]; other site 754035000269 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 754035000270 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 754035000271 Ligand binding site; other site 754035000272 oligomer interface; other site 754035000273 Cytochrome c2 [Energy production and conversion]; Region: COG3474 754035000274 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754035000275 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 754035000276 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754035000277 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 754035000278 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 754035000279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000280 dimer interface [polypeptide binding]; other site 754035000281 conserved gate region; other site 754035000282 putative PBP binding loops; other site 754035000283 ABC-ATPase subunit interface; other site 754035000284 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 754035000285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000286 dimer interface [polypeptide binding]; other site 754035000287 conserved gate region; other site 754035000288 putative PBP binding loops; other site 754035000289 ABC-ATPase subunit interface; other site 754035000290 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 754035000291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000292 Walker A/P-loop; other site 754035000293 ATP binding site [chemical binding]; other site 754035000294 Q-loop/lid; other site 754035000295 ABC transporter signature motif; other site 754035000296 Walker B; other site 754035000297 D-loop; other site 754035000298 H-loop/switch region; other site 754035000299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 754035000300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000301 Walker A/P-loop; other site 754035000302 ATP binding site [chemical binding]; other site 754035000303 Q-loop/lid; other site 754035000304 ABC transporter signature motif; other site 754035000305 Walker B; other site 754035000306 D-loop; other site 754035000307 H-loop/switch region; other site 754035000308 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000309 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035000310 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 754035000311 putative ligand binding site [chemical binding]; other site 754035000312 NAD binding site [chemical binding]; other site 754035000313 dimerization interface [polypeptide binding]; other site 754035000314 catalytic site [active] 754035000315 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 754035000316 AAA domain; Region: AAA_17; pfam13207 754035000317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754035000318 binding surface 754035000319 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 754035000320 TPR motif; other site 754035000321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035000322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035000323 S-adenosylmethionine binding site [chemical binding]; other site 754035000324 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 754035000325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035000326 ATP-dependent DNA ligase; Validated; Region: PRK09247 754035000327 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 754035000328 active site 754035000329 DNA binding site [nucleotide binding] 754035000330 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 754035000331 DNA binding site [nucleotide binding] 754035000332 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 754035000333 EF-hand domain pair; Region: EF_hand_5; pfam13499 754035000334 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 754035000335 EF-hand domain pair; Region: EF_hand_5; pfam13499 754035000336 Ca2+ binding site [ion binding]; other site 754035000337 RNA polymerase sigma factor; Reviewed; Region: PRK05602 754035000338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035000339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035000340 DNA binding residues [nucleotide binding] 754035000341 Predicted integral membrane protein [Function unknown]; Region: COG5612 754035000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 754035000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 754035000344 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 754035000345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754035000346 putative acyl-acceptor binding pocket; other site 754035000347 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 754035000348 acyl-activating enzyme (AAE) consensus motif; other site 754035000349 putative AMP binding site [chemical binding]; other site 754035000350 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 754035000351 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 754035000352 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 754035000353 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 754035000354 PYR/PP interface [polypeptide binding]; other site 754035000355 dimer interface [polypeptide binding]; other site 754035000356 TPP binding site [chemical binding]; other site 754035000357 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 754035000358 TPP-binding site; other site 754035000359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035000360 MarR family; Region: MarR_2; pfam12802 754035000361 MarR family; Region: MarR_2; cl17246 754035000362 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 754035000363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035000364 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 754035000365 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 754035000366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035000367 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035000368 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 754035000369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035000370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000371 ABC-ATPase subunit interface; other site 754035000372 putative PBP binding loops; other site 754035000373 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754035000374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000375 dimer interface [polypeptide binding]; other site 754035000376 conserved gate region; other site 754035000377 putative PBP binding loops; other site 754035000378 ABC-ATPase subunit interface; other site 754035000379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000380 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 754035000381 Walker A/P-loop; other site 754035000382 ATP binding site [chemical binding]; other site 754035000383 Q-loop/lid; other site 754035000384 ABC transporter signature motif; other site 754035000385 Walker B; other site 754035000386 D-loop; other site 754035000387 H-loop/switch region; other site 754035000388 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000390 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035000391 Walker A/P-loop; other site 754035000392 ATP binding site [chemical binding]; other site 754035000393 Q-loop/lid; other site 754035000394 ABC transporter signature motif; other site 754035000395 Walker B; other site 754035000396 D-loop; other site 754035000397 H-loop/switch region; other site 754035000398 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000399 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035000400 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 754035000401 active site 754035000402 metal binding site [ion binding]; metal-binding site 754035000403 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 754035000404 hypothetical protein; Provisional; Region: PRK07236 754035000405 hypothetical protein; Provisional; Region: PRK07236 754035000406 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 754035000407 active site 754035000408 FMN binding site [chemical binding]; other site 754035000409 substrate binding site [chemical binding]; other site 754035000410 homotetramer interface [polypeptide binding]; other site 754035000411 catalytic residue [active] 754035000412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035000413 classical (c) SDRs; Region: SDR_c; cd05233 754035000414 NAD(P) binding site [chemical binding]; other site 754035000415 active site 754035000416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035000417 MarR family; Region: MarR; pfam01047 754035000418 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 754035000419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035000420 substrate binding site [chemical binding]; other site 754035000421 oxyanion hole (OAH) forming residues; other site 754035000422 trimer interface [polypeptide binding]; other site 754035000423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035000424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 754035000425 active site 754035000426 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754035000427 homotrimer interaction site [polypeptide binding]; other site 754035000428 putative active site [active] 754035000429 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 754035000430 active site 754035000431 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035000432 dimer interface [polypeptide binding]; other site 754035000433 non-prolyl cis peptide bond; other site 754035000434 insertion regions; other site 754035000435 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 754035000436 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035000437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035000438 substrate binding pocket [chemical binding]; other site 754035000439 membrane-bound complex binding site; other site 754035000440 hinge residues; other site 754035000441 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 754035000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000443 putative PBP binding loops; other site 754035000444 dimer interface [polypeptide binding]; other site 754035000445 ABC-ATPase subunit interface; other site 754035000446 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754035000447 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 754035000448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035000449 catalytic residue [active] 754035000450 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035000451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000452 Walker A/P-loop; other site 754035000453 ATP binding site [chemical binding]; other site 754035000454 Q-loop/lid; other site 754035000455 ABC transporter signature motif; other site 754035000456 Walker B; other site 754035000457 D-loop; other site 754035000458 H-loop/switch region; other site 754035000459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000460 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035000461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035000462 Walker A/P-loop; other site 754035000463 ATP binding site [chemical binding]; other site 754035000464 Q-loop/lid; other site 754035000465 ABC transporter signature motif; other site 754035000466 Walker B; other site 754035000467 D-loop; other site 754035000468 H-loop/switch region; other site 754035000469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035000470 dipeptide transporter; Provisional; Region: PRK10913 754035000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000472 dimer interface [polypeptide binding]; other site 754035000473 conserved gate region; other site 754035000474 putative PBP binding loops; other site 754035000475 ABC-ATPase subunit interface; other site 754035000476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000478 dimer interface [polypeptide binding]; other site 754035000479 conserved gate region; other site 754035000480 putative PBP binding loops; other site 754035000481 ABC-ATPase subunit interface; other site 754035000482 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035000483 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 754035000484 peptide binding site [polypeptide binding]; other site 754035000485 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 754035000486 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 754035000487 acyl-activating enzyme (AAE) consensus motif; other site 754035000488 putative AMP binding site [chemical binding]; other site 754035000489 putative active site [active] 754035000490 putative CoA binding site [chemical binding]; other site 754035000491 Predicted methyltransferase [General function prediction only]; Region: COG3897 754035000492 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 754035000493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035000494 motif II; other site 754035000495 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 754035000496 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 754035000497 active site 754035000498 dimer interface [polypeptide binding]; other site 754035000499 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 754035000500 dimer interface [polypeptide binding]; other site 754035000501 active site 754035000502 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035000503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035000504 DNA-binding site [nucleotide binding]; DNA binding site 754035000505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035000506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035000507 homodimer interface [polypeptide binding]; other site 754035000508 catalytic residue [active] 754035000509 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 754035000510 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035000511 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035000512 [2Fe-2S] cluster binding site [ion binding]; other site 754035000513 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 754035000514 putative alpha subunit interface [polypeptide binding]; other site 754035000515 putative active site [active] 754035000516 putative substrate binding site [chemical binding]; other site 754035000517 Fe binding site [ion binding]; other site 754035000518 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 754035000519 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 754035000520 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 754035000521 active site residue [active] 754035000522 Uncharacterized conserved protein [Function unknown]; Region: COG4275 754035000523 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 754035000524 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 754035000525 putative hydrophobic ligand binding site [chemical binding]; other site 754035000526 Domain of unknown function DUF59; Region: DUF59; pfam01883 754035000527 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 754035000528 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 754035000529 Walker A motif; other site 754035000530 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 754035000531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035000532 active site 754035000533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035000534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035000535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754035000536 dimerization interface [polypeptide binding]; other site 754035000537 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 754035000538 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 754035000539 putative dimer interface [polypeptide binding]; other site 754035000540 [2Fe-2S] cluster binding site [ion binding]; other site 754035000541 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 754035000542 putative dimer interface [polypeptide binding]; other site 754035000543 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 754035000544 SLBB domain; Region: SLBB; pfam10531 754035000545 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 754035000546 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 754035000547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035000548 catalytic loop [active] 754035000549 iron binding site [ion binding]; other site 754035000550 4Fe-4S binding domain; Region: Fer4; pfam00037 754035000551 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 754035000552 [4Fe-4S] binding site [ion binding]; other site 754035000553 molybdopterin cofactor binding site; other site 754035000554 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 754035000555 molybdopterin cofactor binding site; other site 754035000556 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 754035000557 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 754035000558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035000559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035000560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035000561 DNA binding residues [nucleotide binding] 754035000562 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754035000563 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035000564 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 754035000565 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 754035000566 tetrameric interface [polypeptide binding]; other site 754035000567 NAD binding site [chemical binding]; other site 754035000568 catalytic residues [active] 754035000569 substrate binding site [chemical binding]; other site 754035000570 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035000571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000572 dimer interface [polypeptide binding]; other site 754035000573 conserved gate region; other site 754035000574 putative PBP binding loops; other site 754035000575 ABC-ATPase subunit interface; other site 754035000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000577 putative PBP binding loops; other site 754035000578 dimer interface [polypeptide binding]; other site 754035000579 ABC-ATPase subunit interface; other site 754035000580 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035000581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035000582 Walker A/P-loop; other site 754035000583 ATP binding site [chemical binding]; other site 754035000584 Q-loop/lid; other site 754035000585 ABC transporter signature motif; other site 754035000586 Walker B; other site 754035000587 D-loop; other site 754035000588 H-loop/switch region; other site 754035000589 TOBE domain; Region: TOBE_2; pfam08402 754035000590 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035000591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035000592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035000593 S-adenosylmethionine binding site [chemical binding]; other site 754035000594 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 754035000595 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 754035000596 DNA binding residues [nucleotide binding] 754035000597 putative dimer interface [polypeptide binding]; other site 754035000598 putative metal binding residues [ion binding]; other site 754035000599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035000600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035000601 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 754035000602 putative substrate binding pocket [chemical binding]; other site 754035000603 dimerization interface [polypeptide binding]; other site 754035000604 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754035000605 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754035000606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035000607 S-adenosylmethionine binding site [chemical binding]; other site 754035000608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035000609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035000610 active site 754035000611 phosphorylation site [posttranslational modification] 754035000612 intermolecular recognition site; other site 754035000613 dimerization interface [polypeptide binding]; other site 754035000614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035000615 DNA binding site [nucleotide binding] 754035000616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035000617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 754035000618 dimer interface [polypeptide binding]; other site 754035000619 phosphorylation site [posttranslational modification] 754035000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035000621 ATP binding site [chemical binding]; other site 754035000622 Mg2+ binding site [ion binding]; other site 754035000623 G-X-G motif; other site 754035000624 Transcriptional regulator; Region: Rrf2; pfam02082 754035000625 Rrf2 family protein; Region: rrf2_super; TIGR00738 754035000626 Transcriptional regulator; Region: Rrf2; cl17282 754035000627 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 754035000628 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 754035000629 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035000630 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754035000631 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035000632 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 754035000633 Phosphotransferase enzyme family; Region: APH; pfam01636 754035000634 active site 754035000635 ATP binding site [chemical binding]; other site 754035000636 substrate binding site [chemical binding]; other site 754035000637 dimer interface [polypeptide binding]; other site 754035000638 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035000639 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035000640 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035000641 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035000642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035000643 S-adenosylmethionine binding site [chemical binding]; other site 754035000644 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 754035000645 active site 754035000646 ATP binding site [chemical binding]; other site 754035000647 Phosphotransferase enzyme family; Region: APH; pfam01636 754035000648 substrate binding site [chemical binding]; other site 754035000649 dimer interface [polypeptide binding]; other site 754035000650 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035000651 EamA-like transporter family; Region: EamA; pfam00892 754035000652 cytosine deaminase; Validated; Region: PRK07572 754035000653 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 754035000654 active site 754035000655 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035000656 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035000657 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 754035000658 Walker A/P-loop; other site 754035000659 ATP binding site [chemical binding]; other site 754035000660 Q-loop/lid; other site 754035000661 ABC transporter signature motif; other site 754035000662 Walker B; other site 754035000663 D-loop; other site 754035000664 H-loop/switch region; other site 754035000665 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 754035000666 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 754035000667 dimer interface [polypeptide binding]; other site 754035000668 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 754035000669 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 754035000670 G1 box; other site 754035000671 putative GEF interaction site [polypeptide binding]; other site 754035000672 GTP/Mg2+ binding site [chemical binding]; other site 754035000673 Switch I region; other site 754035000674 G2 box; other site 754035000675 G3 box; other site 754035000676 Switch II region; other site 754035000677 G4 box; other site 754035000678 G5 box; other site 754035000679 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 754035000680 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035000681 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035000682 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 754035000683 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 754035000684 putative active site [active] 754035000685 putative dimer interface [polypeptide binding]; other site 754035000686 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035000687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035000688 putative DNA binding site [nucleotide binding]; other site 754035000689 putative Zn2+ binding site [ion binding]; other site 754035000690 AsnC family; Region: AsnC_trans_reg; pfam01037 754035000691 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754035000692 trimer interface [polypeptide binding]; other site 754035000693 active site 754035000694 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 754035000695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035000696 motif II; other site 754035000697 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 754035000698 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 754035000699 tetramer interface [polypeptide binding]; other site 754035000700 active site 754035000701 Mg2+/Mn2+ binding site [ion binding]; other site 754035000702 Proline racemase; Region: Pro_racemase; pfam05544 754035000703 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 754035000704 CysZ-like protein; Reviewed; Region: PRK12768 754035000705 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 754035000706 EamA-like transporter family; Region: EamA; pfam00892 754035000707 EamA-like transporter family; Region: EamA; pfam00892 754035000708 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 754035000709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035000710 substrate binding site [chemical binding]; other site 754035000711 ATP binding site [chemical binding]; other site 754035000712 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 754035000713 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 754035000714 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754035000715 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 754035000716 putative NAD(P) binding site [chemical binding]; other site 754035000717 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 754035000718 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035000719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035000720 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 754035000721 MutS domain I; Region: MutS_I; pfam01624 754035000722 MutS domain II; Region: MutS_II; pfam05188 754035000723 MutS domain III; Region: MutS_III; pfam05192 754035000724 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 754035000725 Walker A/P-loop; other site 754035000726 ATP binding site [chemical binding]; other site 754035000727 Q-loop/lid; other site 754035000728 ABC transporter signature motif; other site 754035000729 Walker B; other site 754035000730 D-loop; other site 754035000731 H-loop/switch region; other site 754035000732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035000733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035000734 active site 754035000735 catalytic tetrad [active] 754035000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 754035000737 YHS domain; Region: YHS; pfam04945 754035000738 YHS domain; Region: YHS; pfam04945 754035000739 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 754035000740 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754035000741 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754035000742 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754035000743 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754035000744 PII uridylyl-transferase; Provisional; Region: PRK05092 754035000745 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754035000746 metal binding triad; other site 754035000747 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754035000748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754035000749 Zn2+ binding site [ion binding]; other site 754035000750 Mg2+ binding site [ion binding]; other site 754035000751 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 754035000752 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 754035000753 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 754035000754 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 754035000755 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 754035000756 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 754035000757 active site 754035000758 HIGH motif; other site 754035000759 dimer interface [polypeptide binding]; other site 754035000760 KMSKS motif; other site 754035000761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035000762 Ligand Binding Site [chemical binding]; other site 754035000763 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 754035000764 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 754035000765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035000766 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035000767 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 754035000768 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 754035000769 DNA binding residues [nucleotide binding] 754035000770 dimer interface [polypeptide binding]; other site 754035000771 copper binding site [ion binding]; other site 754035000772 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754035000773 nucleoside/Zn binding site; other site 754035000774 dimer interface [polypeptide binding]; other site 754035000775 catalytic motif [active] 754035000776 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 754035000777 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 754035000778 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 754035000779 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 754035000780 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 754035000781 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 754035000782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035000783 active site 754035000784 phosphorylation site [posttranslational modification] 754035000785 intermolecular recognition site; other site 754035000786 dimerization interface [polypeptide binding]; other site 754035000787 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754035000788 Plant transposase (Ptta/En/Spm family); Region: Transposase_24; pfam03004 754035000789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035000790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035000791 ATP binding site [chemical binding]; other site 754035000792 Mg2+ binding site [ion binding]; other site 754035000793 G-X-G motif; other site 754035000794 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 754035000795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035000796 ATP binding site [chemical binding]; other site 754035000797 putative Mg++ binding site [ion binding]; other site 754035000798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035000799 nucleotide binding region [chemical binding]; other site 754035000800 ATP-binding site [chemical binding]; other site 754035000801 Helicase associated domain (HA2); Region: HA2; cl04503 754035000802 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 754035000803 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035000804 EamA-like transporter family; Region: EamA; pfam00892 754035000805 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 754035000806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035000807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035000808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035000809 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035000810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000811 dimer interface [polypeptide binding]; other site 754035000812 conserved gate region; other site 754035000813 putative PBP binding loops; other site 754035000814 ABC-ATPase subunit interface; other site 754035000815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035000816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035000817 dimer interface [polypeptide binding]; other site 754035000818 conserved gate region; other site 754035000819 putative PBP binding loops; other site 754035000820 ABC-ATPase subunit interface; other site 754035000821 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035000822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035000823 Walker A/P-loop; other site 754035000824 ATP binding site [chemical binding]; other site 754035000825 Q-loop/lid; other site 754035000826 ABC transporter signature motif; other site 754035000827 Walker B; other site 754035000828 D-loop; other site 754035000829 H-loop/switch region; other site 754035000830 TOBE domain; Region: TOBE_2; pfam08402 754035000831 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035000832 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035000833 Walker A/P-loop; other site 754035000834 ATP binding site [chemical binding]; other site 754035000835 Q-loop/lid; other site 754035000836 ABC transporter signature motif; other site 754035000837 Walker B; other site 754035000838 D-loop; other site 754035000839 H-loop/switch region; other site 754035000840 TOBE domain; Region: TOBE_2; pfam08402 754035000841 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 754035000842 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 754035000843 DAK2 domain; Region: Dak2; pfam02734 754035000844 DAK2 domain; Region: Dak2; cl03685 754035000845 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 754035000846 active pocket/dimerization site; other site 754035000847 active site 754035000848 phosphorylation site [posttranslational modification] 754035000849 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754035000850 dimerization domain swap beta strand [polypeptide binding]; other site 754035000851 regulatory protein interface [polypeptide binding]; other site 754035000852 active site 754035000853 regulatory phosphorylation site [posttranslational modification]; other site 754035000854 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 754035000855 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754035000856 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754035000857 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754035000858 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 754035000859 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 754035000860 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 754035000861 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 754035000862 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 754035000863 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 754035000864 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 754035000865 acyl-activating enzyme (AAE) consensus motif; other site 754035000866 putative AMP binding site [chemical binding]; other site 754035000867 putative active site [active] 754035000868 putative CoA binding site [chemical binding]; other site 754035000869 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035000870 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 754035000871 Chain length determinant protein; Region: Wzz; pfam02706 754035000872 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 754035000873 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 754035000874 active site 754035000875 tetramer interface; other site 754035000876 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035000877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035000878 active site 754035000879 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754035000880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035000881 active site 754035000882 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754035000883 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 754035000884 Ligand binding site; other site 754035000885 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754035000886 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 754035000887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035000888 active site 754035000889 Uncharacterized conserved protein [Function unknown]; Region: COG5663 754035000890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035000891 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035000892 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 754035000893 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035000894 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035000895 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 754035000896 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035000897 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754035000898 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754035000899 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 754035000900 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 754035000901 active site 754035000902 active site 754035000903 catalytic residues [active] 754035000904 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035000905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035000906 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 754035000907 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 754035000908 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 754035000909 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754035000910 active site 754035000911 dimer interface [polypeptide binding]; other site 754035000912 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754035000913 Ligand Binding Site [chemical binding]; other site 754035000914 Molecular Tunnel; other site 754035000915 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 754035000916 active site 754035000917 nucleotide-binding site [chemical binding]; other site 754035000918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035000919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035000920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035000921 Walker A/P-loop; other site 754035000922 ATP binding site [chemical binding]; other site 754035000923 Q-loop/lid; other site 754035000924 ABC transporter signature motif; other site 754035000925 Walker B; other site 754035000926 D-loop; other site 754035000927 H-loop/switch region; other site 754035000928 Bacterial sugar transferase; Region: Bac_transf; pfam02397 754035000929 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 754035000930 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 754035000931 SLBB domain; Region: SLBB; pfam10531 754035000932 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754035000933 O-Antigen ligase; Region: Wzy_C; pfam04932 754035000934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035000935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035000936 NAD(P) binding site [chemical binding]; other site 754035000937 active site 754035000938 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 754035000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 754035000940 Putative glucoamylase; Region: Glycoamylase; pfam10091 754035000941 mercuric reductase; Validated; Region: PRK06370 754035000942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035000943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035000944 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035000945 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 754035000946 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 754035000947 Uncharacterized conserved protein [Function unknown]; Region: COG3506 754035000948 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 754035000949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035000950 NAD(P) binding site [chemical binding]; other site 754035000951 catalytic residues [active] 754035000952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035000953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035000954 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 754035000955 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 754035000956 Flavin binding site [chemical binding]; other site 754035000957 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035000958 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035000959 Walker A/P-loop; other site 754035000960 ATP binding site [chemical binding]; other site 754035000961 Q-loop/lid; other site 754035000962 ABC transporter signature motif; other site 754035000963 Walker B; other site 754035000964 D-loop; other site 754035000965 H-loop/switch region; other site 754035000966 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 754035000967 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035000968 putative ligand binding site [chemical binding]; other site 754035000969 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035000970 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035000971 TM-ABC transporter signature motif; other site 754035000972 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035000973 TM-ABC transporter signature motif; other site 754035000974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035000975 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035000976 Walker A/P-loop; other site 754035000977 ATP binding site [chemical binding]; other site 754035000978 Q-loop/lid; other site 754035000979 ABC transporter signature motif; other site 754035000980 Walker B; other site 754035000981 D-loop; other site 754035000982 H-loop/switch region; other site 754035000983 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 754035000984 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 754035000985 active site 754035000986 dimer interface [polypeptide binding]; other site 754035000987 non-prolyl cis peptide bond; other site 754035000988 insertion regions; other site 754035000989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 754035000990 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 754035000991 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 754035000992 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 754035000993 active site 754035000994 dimer interface [polypeptide binding]; other site 754035000995 non-prolyl cis peptide bond; other site 754035000996 insertion regions; other site 754035000997 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 754035000998 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035000999 ligand binding site [chemical binding]; other site 754035001000 flexible hinge region; other site 754035001001 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 754035001002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 754035001003 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 754035001004 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 754035001005 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 754035001006 hinge; other site 754035001007 active site 754035001008 cytidylate kinase; Provisional; Region: cmk; PRK00023 754035001009 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 754035001010 CMP-binding site; other site 754035001011 The sites determining sugar specificity; other site 754035001012 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 754035001013 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 754035001014 RNA binding site [nucleotide binding]; other site 754035001015 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 754035001016 RNA binding site [nucleotide binding]; other site 754035001017 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 754035001018 RNA binding site [nucleotide binding]; other site 754035001019 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754035001020 RNA binding site [nucleotide binding]; other site 754035001021 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754035001022 RNA binding site [nucleotide binding]; other site 754035001023 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 754035001024 RNA binding site [nucleotide binding]; other site 754035001025 short chain dehydrogenase; Provisional; Region: PRK12828 754035001026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035001027 NAD(P) binding site [chemical binding]; other site 754035001028 active site 754035001029 hypothetical protein; Provisional; Region: PRK07524 754035001030 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035001031 PYR/PP interface [polypeptide binding]; other site 754035001032 dimer interface [polypeptide binding]; other site 754035001033 TPP binding site [chemical binding]; other site 754035001034 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035001035 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 754035001036 TPP-binding site [chemical binding]; other site 754035001037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035001038 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 754035001039 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 754035001040 Amidinotransferase; Region: Amidinotransf; pfam02274 754035001041 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 754035001042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035001043 Walker A/P-loop; other site 754035001044 ATP binding site [chemical binding]; other site 754035001045 Q-loop/lid; other site 754035001046 ABC transporter signature motif; other site 754035001047 Walker B; other site 754035001048 D-loop; other site 754035001049 H-loop/switch region; other site 754035001050 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 754035001051 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035001052 substrate binding pocket [chemical binding]; other site 754035001053 membrane-bound complex binding site; other site 754035001054 hinge residues; other site 754035001055 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035001056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001057 dimer interface [polypeptide binding]; other site 754035001058 conserved gate region; other site 754035001059 putative PBP binding loops; other site 754035001060 ABC-ATPase subunit interface; other site 754035001061 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035001062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001063 dimer interface [polypeptide binding]; other site 754035001064 conserved gate region; other site 754035001065 putative PBP binding loops; other site 754035001066 ABC-ATPase subunit interface; other site 754035001067 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 754035001068 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754035001069 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 754035001070 putative NAD(P) binding site [chemical binding]; other site 754035001071 active site 754035001072 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754035001073 Cytochrome P450; Region: p450; cl12078 754035001074 Predicted flavoprotein [General function prediction only]; Region: COG0431 754035001075 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035001076 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 754035001077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035001078 Mg2+ binding site [ion binding]; other site 754035001079 G-X-G motif; other site 754035001080 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754035001081 anchoring element; other site 754035001082 dimer interface [polypeptide binding]; other site 754035001083 ATP binding site [chemical binding]; other site 754035001084 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 754035001085 active site 754035001086 putative metal-binding site [ion binding]; other site 754035001087 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754035001088 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 754035001089 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 754035001090 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 754035001091 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 754035001092 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 754035001093 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 754035001094 ligand binding site [chemical binding]; other site 754035001095 homodimer interface [polypeptide binding]; other site 754035001096 NAD(P) binding site [chemical binding]; other site 754035001097 trimer interface B [polypeptide binding]; other site 754035001098 trimer interface A [polypeptide binding]; other site 754035001099 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 754035001100 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 754035001101 Autoinducer synthetase; Region: Autoind_synth; cl17404 754035001102 PAS fold; Region: PAS_7; pfam12860 754035001103 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035001104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035001105 metal binding site [ion binding]; metal-binding site 754035001106 active site 754035001107 I-site; other site 754035001108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035001109 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 754035001110 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 754035001111 dimer interface [polypeptide binding]; other site 754035001112 PYR/PP interface [polypeptide binding]; other site 754035001113 TPP binding site [chemical binding]; other site 754035001114 substrate binding site [chemical binding]; other site 754035001115 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 754035001116 TPP-binding site; other site 754035001117 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 754035001118 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 754035001119 CGNR zinc finger; Region: zf-CGNR; pfam11706 754035001120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035001121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035001122 TM-ABC transporter signature motif; other site 754035001123 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 754035001124 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 754035001125 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 754035001126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754035001127 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 754035001128 putative NAD(P) binding site [chemical binding]; other site 754035001129 catalytic Zn binding site [ion binding]; other site 754035001130 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 754035001131 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 754035001132 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 754035001133 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 754035001134 catalytic triad [active] 754035001135 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754035001136 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 754035001137 putative ligand binding site [chemical binding]; other site 754035001138 NAD binding site [chemical binding]; other site 754035001139 catalytic site [active] 754035001140 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035001141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035001142 DNA binding site [nucleotide binding] 754035001143 domain linker motif; other site 754035001144 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 754035001145 putative dimerization interface [polypeptide binding]; other site 754035001146 putative ligand binding site [chemical binding]; other site 754035001147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035001148 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 754035001149 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754035001150 Helix-turn-helix domain; Region: HTH_18; pfam12833 754035001151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035001152 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035001153 MarR family; Region: MarR_2; pfam12802 754035001154 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 754035001155 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 754035001156 P-loop, Walker A motif; other site 754035001157 Base recognition motif; other site 754035001158 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 754035001159 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 754035001160 FOG: WD40 repeat [General function prediction only]; Region: COG2319 754035001161 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 754035001162 structural tetrad; other site 754035001163 aminotransferase; Validated; Region: PRK07046 754035001164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035001165 inhibitor-cofactor binding pocket; inhibition site 754035001166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035001167 catalytic residue [active] 754035001168 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754035001169 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035001170 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 754035001171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035001172 FeS/SAM binding site; other site 754035001173 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 754035001174 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 754035001175 Fe-S cluster binding site [ion binding]; other site 754035001176 active site 754035001177 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 754035001178 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 754035001179 MOFRL family; Region: MOFRL; pfam05161 754035001180 hypothetical protein; Provisional; Region: PRK02487 754035001181 guanine deaminase; Provisional; Region: PRK09228 754035001182 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 754035001183 active site 754035001184 Predicted membrane protein [Function unknown]; Region: COG3748 754035001185 Protein of unknown function (DUF989); Region: DUF989; pfam06181 754035001186 Cytochrome c; Region: Cytochrom_C; pfam00034 754035001187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035001188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035001189 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035001190 putative effector binding pocket; other site 754035001191 dimerization interface [polypeptide binding]; other site 754035001192 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035001193 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 754035001194 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 754035001195 active site 754035001196 non-prolyl cis peptide bond; other site 754035001197 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 754035001198 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 754035001199 XdhC Rossmann domain; Region: XdhC_C; pfam13478 754035001200 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 754035001201 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035001202 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035001203 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 754035001204 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754035001205 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035001206 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 754035001207 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 754035001208 active site 754035001209 homotetramer interface [polypeptide binding]; other site 754035001210 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 754035001211 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 754035001212 active site 754035001213 catalytic site [active] 754035001214 tetramer interface [polypeptide binding]; other site 754035001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 754035001216 hypothetical protein; Provisional; Region: PRK11171 754035001217 Cupin domain; Region: Cupin_2; pfam07883 754035001218 Cupin domain; Region: Cupin_2; pfam07883 754035001219 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 754035001220 ureidoglycolate hydrolase; Provisional; Region: PRK03606 754035001221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754035001222 nucleoside/Zn binding site; other site 754035001223 dimer interface [polypeptide binding]; other site 754035001224 catalytic motif [active] 754035001225 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 754035001226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035001227 non-specific DNA binding site [nucleotide binding]; other site 754035001228 salt bridge; other site 754035001229 sequence-specific DNA binding site [nucleotide binding]; other site 754035001230 Predicted acyl esterases [General function prediction only]; Region: COG2936 754035001231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035001232 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 754035001233 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035001234 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035001235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035001236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001237 dimer interface [polypeptide binding]; other site 754035001238 conserved gate region; other site 754035001239 ABC-ATPase subunit interface; other site 754035001240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035001241 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754035001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001243 dimer interface [polypeptide binding]; other site 754035001244 conserved gate region; other site 754035001245 ABC-ATPase subunit interface; other site 754035001246 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 754035001247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035001248 Walker A/P-loop; other site 754035001249 ATP binding site [chemical binding]; other site 754035001250 Q-loop/lid; other site 754035001251 ABC transporter signature motif; other site 754035001252 Walker B; other site 754035001253 D-loop; other site 754035001254 H-loop/switch region; other site 754035001255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035001256 Walker A/P-loop; other site 754035001257 ATP binding site [chemical binding]; other site 754035001258 Q-loop/lid; other site 754035001259 ABC transporter signature motif; other site 754035001260 Walker B; other site 754035001261 D-loop; other site 754035001262 H-loop/switch region; other site 754035001263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035001264 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035001265 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 754035001266 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035001267 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 754035001268 Uncharacterized conserved protein [Function unknown]; Region: COG3379 754035001269 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 754035001270 RNA polymerase sigma factor; Provisional; Region: PRK12515 754035001271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035001272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035001273 DNA binding residues [nucleotide binding] 754035001274 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 754035001275 active site 754035001276 catalytic triad [active] 754035001277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035001278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035001279 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035001280 putative effector binding pocket; other site 754035001281 putative dimerization interface [polypeptide binding]; other site 754035001282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035001283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035001284 DNA binding site [nucleotide binding] 754035001285 domain linker motif; other site 754035001286 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 754035001287 ligand binding site [chemical binding]; other site 754035001288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035001289 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035001290 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 754035001291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001292 conserved gate region; other site 754035001293 putative PBP binding loops; other site 754035001294 ABC-ATPase subunit interface; other site 754035001295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035001296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001297 dimer interface [polypeptide binding]; other site 754035001298 conserved gate region; other site 754035001299 putative PBP binding loops; other site 754035001300 ABC-ATPase subunit interface; other site 754035001301 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 754035001302 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 754035001303 active site 754035001304 catalytic site [active] 754035001305 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035001306 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035001307 Walker A/P-loop; other site 754035001308 ATP binding site [chemical binding]; other site 754035001309 Q-loop/lid; other site 754035001310 ABC transporter signature motif; other site 754035001311 Walker B; other site 754035001312 D-loop; other site 754035001313 H-loop/switch region; other site 754035001314 TOBE domain; Region: TOBE_2; pfam08402 754035001315 Protein of unknown function (DUF680); Region: DUF680; pfam05079 754035001316 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 754035001317 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 754035001318 FAD binding pocket [chemical binding]; other site 754035001319 FAD binding motif [chemical binding]; other site 754035001320 phosphate binding motif [ion binding]; other site 754035001321 beta-alpha-beta structure motif; other site 754035001322 NAD binding pocket [chemical binding]; other site 754035001323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035001324 catalytic loop [active] 754035001325 iron binding site [ion binding]; other site 754035001326 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035001327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754035001328 active site 754035001329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035001330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035001331 active site 754035001332 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 754035001333 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 754035001334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754035001335 N-terminal plug; other site 754035001336 ligand-binding site [chemical binding]; other site 754035001337 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 754035001338 BON domain; Region: BON; cl02771 754035001339 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754035001340 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 754035001341 hypothetical protein; Provisional; Region: PRK09256 754035001342 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 754035001343 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754035001344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035001345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035001346 short chain dehydrogenase; Provisional; Region: PRK06180 754035001347 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 754035001348 NADP binding site [chemical binding]; other site 754035001349 active site 754035001350 steroid binding site; other site 754035001351 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 754035001352 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 754035001353 active site 754035001354 substrate-binding site [chemical binding]; other site 754035001355 metal-binding site [ion binding] 754035001356 ATP binding site [chemical binding]; other site 754035001357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035001359 active site 754035001360 phosphorylation site [posttranslational modification] 754035001361 intermolecular recognition site; other site 754035001362 dimerization interface [polypeptide binding]; other site 754035001363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035001364 DNA binding site [nucleotide binding] 754035001365 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 754035001366 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 754035001367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035001368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035001369 dimer interface [polypeptide binding]; other site 754035001370 phosphorylation site [posttranslational modification] 754035001371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035001372 ATP binding site [chemical binding]; other site 754035001373 Mg2+ binding site [ion binding]; other site 754035001374 G-X-G motif; other site 754035001375 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 754035001376 Hpr binding site; other site 754035001377 active site 754035001378 homohexamer subunit interaction site [polypeptide binding]; other site 754035001379 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 754035001380 active pocket/dimerization site; other site 754035001381 active site 754035001382 phosphorylation site [posttranslational modification] 754035001383 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754035001384 dimerization domain swap beta strand [polypeptide binding]; other site 754035001385 regulatory protein interface [polypeptide binding]; other site 754035001386 active site 754035001387 regulatory phosphorylation site [posttranslational modification]; other site 754035001388 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 754035001389 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 754035001390 homotetramer interface [polypeptide binding]; other site 754035001391 ligand binding site [chemical binding]; other site 754035001392 catalytic site [active] 754035001393 NAD binding site [chemical binding]; other site 754035001394 PAS fold; Region: PAS_7; pfam12860 754035001395 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 754035001396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035001397 dimer interface [polypeptide binding]; other site 754035001398 phosphorylation site [posttranslational modification] 754035001399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035001400 ATP binding site [chemical binding]; other site 754035001401 Mg2+ binding site [ion binding]; other site 754035001402 G-X-G motif; other site 754035001403 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 754035001404 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 754035001405 Phosphotransferase enzyme family; Region: APH; pfam01636 754035001406 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 754035001407 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 754035001408 Substrate binding site; other site 754035001409 metal-binding site 754035001410 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 754035001411 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 754035001412 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 754035001413 Part of AAA domain; Region: AAA_19; pfam13245 754035001414 Family description; Region: UvrD_C_2; pfam13538 754035001415 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 754035001416 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754035001417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035001418 catalytic residues [active] 754035001419 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 754035001420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754035001421 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 754035001422 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754035001423 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 754035001424 substrate binding site [chemical binding]; other site 754035001425 active site 754035001426 catalytic residues [active] 754035001427 heterodimer interface [polypeptide binding]; other site 754035001428 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 754035001429 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 754035001430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035001431 catalytic residue [active] 754035001432 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 754035001433 active site 754035001434 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 754035001435 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 754035001436 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 754035001437 benzoate transporter; Region: benE; TIGR00843 754035001438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035001439 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 754035001440 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 754035001441 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 754035001442 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035001443 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 754035001444 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 754035001445 23S rRNA binding site [nucleotide binding]; other site 754035001446 L21 binding site [polypeptide binding]; other site 754035001447 L13 binding site [polypeptide binding]; other site 754035001448 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 754035001449 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 754035001450 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 754035001451 dimer interface [polypeptide binding]; other site 754035001452 motif 1; other site 754035001453 active site 754035001454 motif 2; other site 754035001455 motif 3; other site 754035001456 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 754035001457 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 754035001458 putative tRNA-binding site [nucleotide binding]; other site 754035001459 B3/4 domain; Region: B3_4; pfam03483 754035001460 tRNA synthetase B5 domain; Region: B5; smart00874 754035001461 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 754035001462 dimer interface [polypeptide binding]; other site 754035001463 motif 1; other site 754035001464 motif 3; other site 754035001465 motif 2; other site 754035001466 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 754035001467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 754035001468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035001469 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035001470 active site 754035001471 catalytic tetrad [active] 754035001472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035001473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035001474 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035001475 putative effector binding pocket; other site 754035001476 putative dimerization interface [polypeptide binding]; other site 754035001477 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 754035001478 Uncharacterized conserved protein [Function unknown]; Region: COG2353 754035001479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035001480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035001481 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035001482 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 754035001483 FAD binding domain; Region: FAD_binding_2; pfam00890 754035001484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035001485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035001486 ATP binding site [chemical binding]; other site 754035001487 Mg2+ binding site [ion binding]; other site 754035001488 G-X-G motif; other site 754035001489 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 754035001490 ribonuclease P; Reviewed; Region: rnpA; PRK01313 754035001491 membrane protein insertase; Provisional; Region: PRK01318 754035001492 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 754035001493 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 754035001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035001495 S-adenosylmethionine binding site [chemical binding]; other site 754035001496 Erythromycin esterase; Region: Erythro_esteras; pfam05139 754035001497 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 754035001498 Fasciclin domain; Region: Fasciclin; pfam02469 754035001499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035001500 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035001501 putative substrate translocation pore; other site 754035001502 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 754035001503 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035001504 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035001505 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035001506 MarR family; Region: MarR_2; pfam12802 754035001507 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 754035001508 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 754035001509 trimer interface [polypeptide binding]; other site 754035001510 active site 754035001511 substrate binding site [chemical binding]; other site 754035001512 CoA binding site [chemical binding]; other site 754035001513 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 754035001514 G1 box; other site 754035001515 GTP/Mg2+ binding site [chemical binding]; other site 754035001516 Switch I region; other site 754035001517 G2 box; other site 754035001518 G3 box; other site 754035001519 Switch II region; other site 754035001520 G4 box; other site 754035001521 G5 box; other site 754035001522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035001523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035001524 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 754035001525 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 754035001526 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035001527 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035001528 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035001529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035001530 putative substrate translocation pore; other site 754035001531 methionine sulfoxide reductase B; Provisional; Region: PRK00222 754035001532 SelR domain; Region: SelR; pfam01641 754035001533 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 754035001534 Fasciclin domain; Region: Fasciclin; pfam02469 754035001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 754035001536 Anti-sigma-K factor rskA; Region: RskA; pfam10099 754035001537 RNA polymerase sigma factor; Provisional; Region: PRK12514 754035001538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035001539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035001540 DNA binding residues [nucleotide binding] 754035001541 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 754035001542 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 754035001543 Amidase; Region: Amidase; cl11426 754035001544 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 754035001545 homohexameric interface [polypeptide binding]; other site 754035001546 feedback inhibition sensing region; other site 754035001547 nucleotide binding site [chemical binding]; other site 754035001548 N-acetyl-L-glutamate binding site [chemical binding]; other site 754035001549 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 754035001550 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 754035001551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035001552 FeS/SAM binding site; other site 754035001553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035001554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035001555 putative DNA binding site [nucleotide binding]; other site 754035001556 putative Zn2+ binding site [ion binding]; other site 754035001557 AsnC family; Region: AsnC_trans_reg; pfam01037 754035001558 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 754035001559 cofactor binding site; other site 754035001560 metal binding site [ion binding]; metal-binding site 754035001561 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 754035001562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035001563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035001564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035001565 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 754035001566 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035001567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035001568 putative DNA binding site [nucleotide binding]; other site 754035001569 putative Zn2+ binding site [ion binding]; other site 754035001570 AsnC family; Region: AsnC_trans_reg; pfam01037 754035001571 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035001572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035001573 substrate binding pocket [chemical binding]; other site 754035001574 membrane-bound complex binding site; other site 754035001575 hinge residues; other site 754035001576 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035001577 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 754035001578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001579 dimer interface [polypeptide binding]; other site 754035001580 conserved gate region; other site 754035001581 putative PBP binding loops; other site 754035001582 ABC-ATPase subunit interface; other site 754035001583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035001584 MarR family; Region: MarR_2; cl17246 754035001585 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035001586 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035001587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035001588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035001589 metal binding site [ion binding]; metal-binding site 754035001590 active site 754035001591 I-site; other site 754035001592 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 754035001593 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 754035001594 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 754035001595 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 754035001596 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 754035001597 trimer interface [polypeptide binding]; other site 754035001598 active site 754035001599 substrate binding site [chemical binding]; other site 754035001600 CoA binding site [chemical binding]; other site 754035001601 Predicted membrane protein [Function unknown]; Region: COG3152 754035001602 Predicted membrane protein [Function unknown]; Region: COG3152 754035001603 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 754035001604 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754035001605 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754035001606 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 754035001607 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 754035001608 metal binding site [ion binding]; metal-binding site 754035001609 dimer interface [polypeptide binding]; other site 754035001610 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 754035001611 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 754035001612 dimerization interface 3.5A [polypeptide binding]; other site 754035001613 active site 754035001614 Predicted acetyltransferase [General function prediction only]; Region: COG3153 754035001615 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 754035001616 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 754035001617 putative active site [active] 754035001618 substrate binding site [chemical binding]; other site 754035001619 putative cosubstrate binding site; other site 754035001620 catalytic site [active] 754035001621 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 754035001622 substrate binding site [chemical binding]; other site 754035001623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 754035001624 active site 754035001625 catalytic residues [active] 754035001626 metal binding site [ion binding]; metal-binding site 754035001627 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 754035001628 RmuC family; Region: RmuC; pfam02646 754035001629 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035001630 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754035001631 Cation efflux family; Region: Cation_efflux; pfam01545 754035001632 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035001633 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 754035001634 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 754035001635 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035001636 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035001637 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 754035001638 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754035001639 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754035001640 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 754035001641 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 754035001642 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035001643 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 754035001644 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035001645 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 754035001646 active site 754035001647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035001648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035001649 DNA binding site [nucleotide binding] 754035001650 domain linker motif; other site 754035001651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754035001652 dimerization interface [polypeptide binding]; other site 754035001653 ligand binding site [chemical binding]; other site 754035001654 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035001655 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035001656 Walker A/P-loop; other site 754035001657 ATP binding site [chemical binding]; other site 754035001658 Q-loop/lid; other site 754035001659 ABC transporter signature motif; other site 754035001660 Walker B; other site 754035001661 D-loop; other site 754035001662 H-loop/switch region; other site 754035001663 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035001664 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 754035001665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035001666 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035001667 TM-ABC transporter signature motif; other site 754035001668 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 754035001669 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035001670 putative ligand binding site [chemical binding]; other site 754035001671 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 754035001672 MarR family; Region: MarR_2; cl17246 754035001673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035001674 Amino acid synthesis; Region: AA_synth; pfam06684 754035001675 Uncharacterized conserved protein [Function unknown]; Region: COG2122; cl17892 754035001676 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035001677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035001678 catalytic loop [active] 754035001679 iron binding site [ion binding]; other site 754035001680 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035001681 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035001682 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035001683 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035001684 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035001685 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 754035001686 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 754035001687 Isochorismatase family; Region: Isochorismatase; pfam00857 754035001688 catalytic triad [active] 754035001689 metal binding site [ion binding]; metal-binding site 754035001690 conserved cis-peptide bond; other site 754035001691 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 754035001692 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 754035001693 transmembrane helices; other site 754035001694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035001695 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035001696 Walker A/P-loop; other site 754035001697 ATP binding site [chemical binding]; other site 754035001698 Q-loop/lid; other site 754035001699 ABC transporter signature motif; other site 754035001700 Walker B; other site 754035001701 D-loop; other site 754035001702 H-loop/switch region; other site 754035001703 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035001704 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035001705 Walker A/P-loop; other site 754035001706 ATP binding site [chemical binding]; other site 754035001707 Q-loop/lid; other site 754035001708 ABC transporter signature motif; other site 754035001709 Walker B; other site 754035001710 D-loop; other site 754035001711 H-loop/switch region; other site 754035001712 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035001713 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035001714 TM-ABC transporter signature motif; other site 754035001715 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035001716 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035001717 TM-ABC transporter signature motif; other site 754035001718 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035001719 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 754035001720 ligand binding site [chemical binding]; other site 754035001721 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 754035001722 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 754035001723 active site 754035001724 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035001725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035001726 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035001727 dimerization interface [polypeptide binding]; other site 754035001728 substrate binding pocket [chemical binding]; other site 754035001729 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 754035001730 agmatinase; Region: agmatinase; TIGR01230 754035001731 oligomer interface [polypeptide binding]; other site 754035001732 putative active site [active] 754035001733 Mn binding site [ion binding]; other site 754035001734 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035001735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035001736 substrate binding pocket [chemical binding]; other site 754035001737 membrane-bound complex binding site; other site 754035001738 hinge residues; other site 754035001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001740 dimer interface [polypeptide binding]; other site 754035001741 conserved gate region; other site 754035001742 putative PBP binding loops; other site 754035001743 ABC-ATPase subunit interface; other site 754035001744 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 754035001745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001746 putative PBP binding loops; other site 754035001747 dimer interface [polypeptide binding]; other site 754035001748 ABC-ATPase subunit interface; other site 754035001749 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035001750 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 754035001751 putative NAD(P) binding site [chemical binding]; other site 754035001752 multidrug efflux protein; Reviewed; Region: PRK01766 754035001753 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 754035001754 cation binding site [ion binding]; other site 754035001755 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754035001756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035001757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035001758 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035001759 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035001760 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 754035001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001762 putative PBP binding loops; other site 754035001763 dimer interface [polypeptide binding]; other site 754035001764 ABC-ATPase subunit interface; other site 754035001765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035001766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001767 dimer interface [polypeptide binding]; other site 754035001768 conserved gate region; other site 754035001769 putative PBP binding loops; other site 754035001770 ABC-ATPase subunit interface; other site 754035001771 L-idonate 5-dehydrogenase; Region: PLN02702 754035001772 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 754035001773 inhibitor binding site; inhibition site 754035001774 catalytic Zn binding site [ion binding]; other site 754035001775 structural Zn binding site [ion binding]; other site 754035001776 NADP binding site [chemical binding]; other site 754035001777 tetramer interface [polypeptide binding]; other site 754035001778 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035001779 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035001780 Walker A/P-loop; other site 754035001781 ATP binding site [chemical binding]; other site 754035001782 Q-loop/lid; other site 754035001783 ABC transporter signature motif; other site 754035001784 Walker B; other site 754035001785 D-loop; other site 754035001786 H-loop/switch region; other site 754035001787 TOBE domain; Region: TOBE; pfam03459 754035001788 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 754035001789 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 754035001790 N- and C-terminal domain interface [polypeptide binding]; other site 754035001791 active site 754035001792 MgATP binding site [chemical binding]; other site 754035001793 catalytic site [active] 754035001794 metal binding site [ion binding]; metal-binding site 754035001795 carbohydrate binding site [chemical binding]; other site 754035001796 putative homodimer interface [polypeptide binding]; other site 754035001797 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 754035001798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035001799 motif II; other site 754035001800 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 754035001801 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 754035001802 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754035001803 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754035001804 sorbitol dehydrogenase; Provisional; Region: PRK07067 754035001805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035001806 NAD(P) binding site [chemical binding]; other site 754035001807 active site 754035001808 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035001809 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035001810 Walker A/P-loop; other site 754035001811 ATP binding site [chemical binding]; other site 754035001812 Q-loop/lid; other site 754035001813 ABC transporter signature motif; other site 754035001814 Walker B; other site 754035001815 D-loop; other site 754035001816 H-loop/switch region; other site 754035001817 TOBE domain; Region: TOBE_2; pfam08402 754035001818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035001819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001820 dimer interface [polypeptide binding]; other site 754035001821 conserved gate region; other site 754035001822 putative PBP binding loops; other site 754035001823 ABC-ATPase subunit interface; other site 754035001824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035001825 putative PBP binding loops; other site 754035001826 dimer interface [polypeptide binding]; other site 754035001827 ABC-ATPase subunit interface; other site 754035001828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035001829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035001830 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035001831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035001832 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035001833 dimerization interface [polypeptide binding]; other site 754035001834 substrate binding pocket [chemical binding]; other site 754035001835 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035001836 MarR family; Region: MarR_2; pfam12802 754035001837 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035001838 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 754035001839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 754035001840 motif I; other site 754035001841 active site 754035001842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035001843 motif II; other site 754035001844 hypothetical protein; Provisional; Region: PRK07490 754035001845 active site 754035001846 intersubunit interface [polypeptide binding]; other site 754035001847 Zn2+ binding site [ion binding]; other site 754035001848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035001849 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 754035001850 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 754035001851 UreF; Region: UreF; pfam01730 754035001852 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 754035001853 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 754035001854 dimer interface [polypeptide binding]; other site 754035001855 catalytic residues [active] 754035001856 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 754035001857 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035001858 putative C-terminal domain interface [polypeptide binding]; other site 754035001859 putative GSH binding site (G-site) [chemical binding]; other site 754035001860 putative dimer interface [polypeptide binding]; other site 754035001861 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 754035001862 dimer interface [polypeptide binding]; other site 754035001863 N-terminal domain interface [polypeptide binding]; other site 754035001864 putative substrate binding pocket (H-site) [chemical binding]; other site 754035001865 Domain of unknown function DUF29; Region: DUF29; pfam01724 754035001866 urease subunit alpha; Reviewed; Region: ureC; PRK13207 754035001867 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 754035001868 subunit interactions [polypeptide binding]; other site 754035001869 active site 754035001870 flap region; other site 754035001871 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 754035001872 gamma-beta subunit interface [polypeptide binding]; other site 754035001873 alpha-beta subunit interface [polypeptide binding]; other site 754035001874 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 754035001875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 754035001876 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 754035001877 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 754035001878 alpha-gamma subunit interface [polypeptide binding]; other site 754035001879 beta-gamma subunit interface [polypeptide binding]; other site 754035001880 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 754035001881 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 754035001882 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 754035001883 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035001884 dimer interface [polypeptide binding]; other site 754035001885 active site 754035001886 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 754035001887 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035001888 C-terminal domain interface [polypeptide binding]; other site 754035001889 GSH binding site (G-site) [chemical binding]; other site 754035001890 dimer interface [polypeptide binding]; other site 754035001891 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 754035001892 dimer interface [polypeptide binding]; other site 754035001893 N-terminal domain interface [polypeptide binding]; other site 754035001894 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 754035001895 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 754035001896 active site 754035001897 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 754035001898 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754035001899 Predicted membrane protein [Function unknown]; Region: COG4420 754035001900 Protein of unknown function (DUF736); Region: DUF736; pfam05284 754035001901 Predicted transcriptional regulator [Transcription]; Region: COG4957 754035001902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 754035001903 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 754035001904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754035001905 TPR motif; other site 754035001906 binding surface 754035001907 TPR repeat; Region: TPR_11; pfam13414 754035001908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035001909 TPR motif; other site 754035001910 binding surface 754035001911 Uncharacterized conserved protein [Function unknown]; Region: COG1944 754035001912 YcaO-like family; Region: YcaO; pfam02624 754035001913 TfuA-like protein; Region: TfuA; pfam07812 754035001914 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 754035001915 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754035001916 active site 754035001917 DNA binding site [nucleotide binding] 754035001918 Int/Topo IB signature motif; other site 754035001919 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 754035001920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035001921 NAD(P) binding site [chemical binding]; other site 754035001922 active site 754035001923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035001924 dimerization interface [polypeptide binding]; other site 754035001925 putative DNA binding site [nucleotide binding]; other site 754035001926 putative Zn2+ binding site [ion binding]; other site 754035001927 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 754035001928 putative hydrophobic ligand binding site [chemical binding]; other site 754035001929 CLM binding site; other site 754035001930 L1 loop; other site 754035001931 DNA binding site [nucleotide binding] 754035001932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035001933 S-adenosylmethionine binding site [chemical binding]; other site 754035001934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035001935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035001936 DNA binding site [nucleotide binding] 754035001937 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 754035001938 putative dimerization interface [polypeptide binding]; other site 754035001939 putative ligand binding site [chemical binding]; other site 754035001940 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 754035001941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035001942 ligand binding site [chemical binding]; other site 754035001943 dimerization interface [polypeptide binding]; other site 754035001944 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035001945 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035001946 Walker A/P-loop; other site 754035001947 ATP binding site [chemical binding]; other site 754035001948 Q-loop/lid; other site 754035001949 ABC transporter signature motif; other site 754035001950 Walker B; other site 754035001951 D-loop; other site 754035001952 H-loop/switch region; other site 754035001953 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035001954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035001955 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035001956 TM-ABC transporter signature motif; other site 754035001957 Predicted membrane protein [Function unknown]; Region: COG4280 754035001958 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 754035001959 active site 754035001960 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 754035001961 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035001962 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 754035001963 active site 754035001964 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 754035001965 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 754035001966 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035001967 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 754035001968 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035001969 PYR/PP interface [polypeptide binding]; other site 754035001970 dimer interface [polypeptide binding]; other site 754035001971 TPP binding site [chemical binding]; other site 754035001972 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035001973 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 754035001974 TPP-binding site; other site 754035001975 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035001976 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754035001977 substrate binding site [chemical binding]; other site 754035001978 ATP binding site [chemical binding]; other site 754035001979 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 754035001980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 754035001981 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035001982 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035001983 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035001984 putative active site [active] 754035001985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035001986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035001987 Predicted transcriptional regulator [Transcription]; Region: COG2378 754035001988 HTH domain; Region: HTH_11; pfam08279 754035001989 WYL domain; Region: WYL; pfam13280 754035001990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035001991 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 754035001992 putative hydrophobic ligand binding site [chemical binding]; other site 754035001993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035001994 dimerization interface [polypeptide binding]; other site 754035001995 putative DNA binding site [nucleotide binding]; other site 754035001996 putative Zn2+ binding site [ion binding]; other site 754035001997 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 754035001998 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754035001999 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 754035002000 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 754035002001 putative active site [active] 754035002002 short chain dehydrogenase; Provisional; Region: PRK06198 754035002003 classical (c) SDRs; Region: SDR_c; cd05233 754035002004 NAD(P) binding site [chemical binding]; other site 754035002005 active site 754035002006 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035002007 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035002008 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035002009 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035002010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035002011 Walker A/P-loop; other site 754035002012 ATP binding site [chemical binding]; other site 754035002013 Q-loop/lid; other site 754035002014 ABC transporter signature motif; other site 754035002015 Walker B; other site 754035002016 D-loop; other site 754035002017 H-loop/switch region; other site 754035002018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035002019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035002020 TM-ABC transporter signature motif; other site 754035002021 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 754035002022 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035002023 putative ligand binding site [chemical binding]; other site 754035002024 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035002025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035002026 DNA binding site [nucleotide binding] 754035002027 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 754035002028 putative ligand binding site [chemical binding]; other site 754035002029 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 754035002030 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 754035002031 putative di-iron ligands [ion binding]; other site 754035002032 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 754035002033 [2Fe-2S] cluster binding site [ion binding]; other site 754035002034 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 754035002035 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035002036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035002037 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 754035002038 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 754035002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035002040 Walker A motif; other site 754035002041 ATP binding site [chemical binding]; other site 754035002042 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 754035002043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754035002044 hypothetical protein; Provisional; Region: PRK00944 754035002045 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 754035002046 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 754035002047 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035002048 Coenzyme A binding pocket [chemical binding]; other site 754035002049 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 754035002050 active site 754035002051 HslU subunit interaction site [polypeptide binding]; other site 754035002052 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 754035002053 putative active site pocket [active] 754035002054 4-fold oligomerization interface [polypeptide binding]; other site 754035002055 metal binding residues [ion binding]; metal-binding site 754035002056 3-fold/trimer interface [polypeptide binding]; other site 754035002057 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 754035002058 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 754035002059 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 754035002060 putative active site [active] 754035002061 oxyanion strand; other site 754035002062 catalytic triad [active] 754035002063 Uncharacterized conserved protein [Function unknown]; Region: COG5470 754035002064 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 754035002065 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 754035002066 catalytic residues [active] 754035002067 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 754035002068 active site 754035002069 Mn binding site [ion binding]; other site 754035002070 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 754035002071 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 754035002072 substrate binding site [chemical binding]; other site 754035002073 glutamase interaction surface [polypeptide binding]; other site 754035002074 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 754035002075 metal binding site [ion binding]; metal-binding site 754035002076 pantothenate kinase; Provisional; Region: PRK05439 754035002077 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 754035002078 ATP-binding site [chemical binding]; other site 754035002079 CoA-binding site [chemical binding]; other site 754035002080 Mg2+-binding site [ion binding]; other site 754035002081 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 754035002082 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035002083 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035002084 protein binding site [polypeptide binding]; other site 754035002085 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035002086 protein binding site [polypeptide binding]; other site 754035002087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035002088 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 754035002089 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 754035002090 active site 754035002091 ADP/pyrophosphate binding site [chemical binding]; other site 754035002092 dimerization interface [polypeptide binding]; other site 754035002093 allosteric effector site; other site 754035002094 fructose-1,6-bisphosphate binding site; other site 754035002095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035002096 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035002097 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035002098 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 754035002099 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754035002100 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 754035002101 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 754035002102 N- and C-terminal domain interface [polypeptide binding]; other site 754035002103 D-xylulose kinase; Region: XylB; TIGR01312 754035002104 active site 754035002105 MgATP binding site [chemical binding]; other site 754035002106 catalytic site [active] 754035002107 metal binding site [ion binding]; metal-binding site 754035002108 xylulose binding site [chemical binding]; other site 754035002109 homodimer interface [polypeptide binding]; other site 754035002110 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035002111 xylose isomerase; Provisional; Region: PRK05474 754035002112 xylose isomerase; Region: xylose_isom_A; TIGR02630 754035002113 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035002114 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035002115 conserved cys residue [active] 754035002116 Uncharacterized conserved protein [Function unknown]; Region: COG3246 754035002117 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 754035002118 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 754035002119 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035002120 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035002121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035002122 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 754035002123 active site 754035002124 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 754035002125 CoA binding domain; Region: CoA_binding_2; pfam13380 754035002126 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 754035002127 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 754035002128 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 754035002129 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035002130 substrate binding site [chemical binding]; other site 754035002131 oxyanion hole (OAH) forming residues; other site 754035002132 trimer interface [polypeptide binding]; other site 754035002133 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754035002134 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035002135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035002136 DNA-binding site [nucleotide binding]; DNA binding site 754035002137 FCD domain; Region: FCD; pfam07729 754035002138 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035002139 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035002141 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035002142 Walker A/P-loop; other site 754035002143 ATP binding site [chemical binding]; other site 754035002144 Q-loop/lid; other site 754035002145 ABC transporter signature motif; other site 754035002146 Walker B; other site 754035002147 D-loop; other site 754035002148 H-loop/switch region; other site 754035002149 TOBE domain; Region: TOBE_2; pfam08402 754035002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002151 dimer interface [polypeptide binding]; other site 754035002152 conserved gate region; other site 754035002153 putative PBP binding loops; other site 754035002154 ABC-ATPase subunit interface; other site 754035002155 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002157 dimer interface [polypeptide binding]; other site 754035002158 conserved gate region; other site 754035002159 putative PBP binding loops; other site 754035002160 ABC-ATPase subunit interface; other site 754035002161 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 754035002162 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 754035002163 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 754035002164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035002165 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 754035002166 acyl-activating enzyme (AAE) consensus motif; other site 754035002167 acyl-activating enzyme (AAE) consensus motif; other site 754035002168 putative AMP binding site [chemical binding]; other site 754035002169 putative active site [active] 754035002170 putative CoA binding site [chemical binding]; other site 754035002171 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 754035002172 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754035002173 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754035002174 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 754035002175 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754035002176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035002177 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754035002178 putative active site [active] 754035002179 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035002180 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035002181 TM-ABC transporter signature motif; other site 754035002182 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035002183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035002184 TM-ABC transporter signature motif; other site 754035002185 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035002186 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035002187 Walker A/P-loop; other site 754035002188 ATP binding site [chemical binding]; other site 754035002189 Q-loop/lid; other site 754035002190 ABC transporter signature motif; other site 754035002191 Walker B; other site 754035002192 D-loop; other site 754035002193 H-loop/switch region; other site 754035002194 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035002195 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035002196 Walker A/P-loop; other site 754035002197 ATP binding site [chemical binding]; other site 754035002198 Q-loop/lid; other site 754035002199 ABC transporter signature motif; other site 754035002200 Walker B; other site 754035002201 D-loop; other site 754035002202 H-loop/switch region; other site 754035002203 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035002204 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 754035002205 putative ligand binding site [chemical binding]; other site 754035002206 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 754035002207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035002208 Walker A/P-loop; other site 754035002209 ATP binding site [chemical binding]; other site 754035002210 Q-loop/lid; other site 754035002211 ABC transporter signature motif; other site 754035002212 Walker B; other site 754035002213 D-loop; other site 754035002214 H-loop/switch region; other site 754035002215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035002216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035002217 Walker A/P-loop; other site 754035002218 ATP binding site [chemical binding]; other site 754035002219 Q-loop/lid; other site 754035002220 ABC transporter signature motif; other site 754035002221 Walker B; other site 754035002222 D-loop; other site 754035002223 H-loop/switch region; other site 754035002224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 754035002225 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 754035002226 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035002227 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 754035002228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002230 dimer interface [polypeptide binding]; other site 754035002231 conserved gate region; other site 754035002232 putative PBP binding loops; other site 754035002233 ABC-ATPase subunit interface; other site 754035002234 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035002235 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754035002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002237 dimer interface [polypeptide binding]; other site 754035002238 conserved gate region; other site 754035002239 putative PBP binding loops; other site 754035002240 ABC-ATPase subunit interface; other site 754035002241 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 754035002242 ANTAR domain; Region: ANTAR; pfam03861 754035002243 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035002244 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035002245 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 754035002246 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 754035002247 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 754035002248 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 754035002249 Walker A/P-loop; other site 754035002250 ATP binding site [chemical binding]; other site 754035002251 Q-loop/lid; other site 754035002252 ABC transporter signature motif; other site 754035002253 Walker B; other site 754035002254 D-loop; other site 754035002255 H-loop/switch region; other site 754035002256 NIL domain; Region: NIL; pfam09383 754035002257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002258 dimer interface [polypeptide binding]; other site 754035002259 conserved gate region; other site 754035002260 ABC-ATPase subunit interface; other site 754035002261 Bacterial transcriptional activator domain; Region: BTAD; smart01043 754035002262 Predicted integral membrane protein [Function unknown]; Region: COG5616 754035002263 TPR repeat; Region: TPR_11; pfam13414 754035002264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035002265 TPR motif; other site 754035002266 TPR repeat; Region: TPR_11; pfam13414 754035002267 binding surface 754035002268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035002269 TPR motif; other site 754035002270 binding surface 754035002271 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035002272 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035002273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035002274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035002275 substrate binding pocket [chemical binding]; other site 754035002276 membrane-bound complex binding site; other site 754035002277 hinge residues; other site 754035002278 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 754035002279 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 754035002280 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 754035002281 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 754035002282 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 754035002283 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 754035002284 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 754035002285 FAD binding pocket [chemical binding]; other site 754035002286 FAD binding motif [chemical binding]; other site 754035002287 phosphate binding motif [ion binding]; other site 754035002288 beta-alpha-beta structure motif; other site 754035002289 NAD binding pocket [chemical binding]; other site 754035002290 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 754035002291 intersubunit interface [polypeptide binding]; other site 754035002292 active site 754035002293 catalytic residue [active] 754035002294 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 754035002295 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035002296 NAD(P) binding site [chemical binding]; other site 754035002297 catalytic residues [active] 754035002298 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 754035002299 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 754035002300 NAD(P) binding site [chemical binding]; other site 754035002301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035002302 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 754035002303 NAD binding site [chemical binding]; other site 754035002304 homotetramer interface [polypeptide binding]; other site 754035002305 homodimer interface [polypeptide binding]; other site 754035002306 active site 754035002307 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 754035002308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035002309 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035002310 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035002311 Walker A/P-loop; other site 754035002312 ATP binding site [chemical binding]; other site 754035002313 Q-loop/lid; other site 754035002314 ABC transporter signature motif; other site 754035002315 Walker B; other site 754035002316 D-loop; other site 754035002317 H-loop/switch region; other site 754035002318 TOBE domain; Region: TOBE_2; pfam08402 754035002319 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035002320 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035002321 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035002322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002323 dimer interface [polypeptide binding]; other site 754035002324 conserved gate region; other site 754035002325 putative PBP binding loops; other site 754035002326 ABC-ATPase subunit interface; other site 754035002327 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754035002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002329 dimer interface [polypeptide binding]; other site 754035002330 conserved gate region; other site 754035002331 putative PBP binding loops; other site 754035002332 ABC-ATPase subunit interface; other site 754035002333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035002334 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035002335 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 754035002336 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 754035002337 putative active site [active] 754035002338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035002339 nucleotide binding site [chemical binding]; other site 754035002340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 754035002341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035002342 DNA-binding site [nucleotide binding]; DNA binding site 754035002343 UTRA domain; Region: UTRA; pfam07702 754035002344 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 754035002345 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754035002346 dimer interface [polypeptide binding]; other site 754035002347 active site 754035002348 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754035002349 dimer interface [polypeptide binding]; other site 754035002350 active site 754035002351 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 754035002352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035002353 active site 754035002354 Predicted dehydrogenase [General function prediction only]; Region: COG0579 754035002355 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035002356 malonyl-CoA synthase; Validated; Region: PRK07514 754035002357 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 754035002358 acyl-activating enzyme (AAE) consensus motif; other site 754035002359 active site 754035002360 AMP binding site [chemical binding]; other site 754035002361 CoA binding site [chemical binding]; other site 754035002362 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035002363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035002364 DNA-binding site [nucleotide binding]; DNA binding site 754035002365 FCD domain; Region: FCD; pfam07729 754035002366 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 754035002367 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 754035002368 substrate binding site [chemical binding]; other site 754035002369 hexamer interface [polypeptide binding]; other site 754035002370 metal binding site [ion binding]; metal-binding site 754035002371 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 754035002372 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 754035002373 nucleotide binding site [chemical binding]; other site 754035002374 NEF interaction site [polypeptide binding]; other site 754035002375 SBD interface [polypeptide binding]; other site 754035002376 chaperone protein DnaJ; Provisional; Region: PRK10767 754035002377 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035002378 HSP70 interaction site [polypeptide binding]; other site 754035002379 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 754035002380 substrate binding site [polypeptide binding]; other site 754035002381 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754035002382 Zn binding sites [ion binding]; other site 754035002383 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754035002384 dimer interface [polypeptide binding]; other site 754035002385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035002386 S-adenosylmethionine binding site [chemical binding]; other site 754035002387 Predicted flavoprotein [General function prediction only]; Region: COG0431 754035002388 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035002389 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 754035002390 active site 754035002391 dimer interface [polypeptide binding]; other site 754035002392 Uncharacterized conserved protein [Function unknown]; Region: COG5470 754035002393 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035002394 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 754035002395 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 754035002396 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 754035002397 active site 754035002398 intersubunit interface [polypeptide binding]; other site 754035002399 catalytic residue [active] 754035002400 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 754035002401 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 754035002402 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 754035002403 classical (c) SDRs; Region: SDR_c; cd05233 754035002404 NAD(P) binding site [chemical binding]; other site 754035002405 active site 754035002406 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035002407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035002408 metal binding site [ion binding]; metal-binding site 754035002409 active site 754035002410 I-site; other site 754035002411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035002412 GtrA-like protein; Region: GtrA; pfam04138 754035002413 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 754035002414 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754035002415 Ligand binding site; other site 754035002416 Putative Catalytic site; other site 754035002417 DXD motif; other site 754035002418 glutathione synthetase; Provisional; Region: PRK05246 754035002419 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 754035002420 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 754035002421 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 754035002422 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754035002423 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 754035002424 TIR domain; Region: TIR_2; pfam13676 754035002425 Protein of unknown function (DUF770); Region: DUF770; cl01402 754035002426 HNH nucleases; Region: HNHc; smart00507 754035002427 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754035002428 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 754035002429 catalytic residues [active] 754035002430 catalytic nucleophile [active] 754035002431 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 754035002432 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 754035002433 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 754035002434 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 754035002435 Catalytic site; other site 754035002436 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 754035002437 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754035002438 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754035002439 catalytic residues [active] 754035002440 catalytic nucleophile [active] 754035002441 Recombinase; Region: Recombinase; pfam07508 754035002442 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 754035002443 Exocyst complex subunit Sec15-like; Region: Sec15; pfam04091 754035002444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035002445 Methyltransferase domain; Region: Methyltransf_11; pfam08241 754035002446 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 754035002447 active site 754035002448 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 754035002449 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 754035002450 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 754035002451 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 754035002452 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 754035002453 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 754035002454 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 754035002455 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 754035002456 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 754035002457 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035002458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035002459 DNA binding site [nucleotide binding] 754035002460 Predicted integral membrane protein [Function unknown]; Region: COG5616 754035002461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035002462 TPR motif; other site 754035002463 binding surface 754035002464 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 754035002465 tyrosine decarboxylase; Region: PLN02880 754035002466 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 754035002467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002468 catalytic residue [active] 754035002469 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754035002470 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754035002471 dimer interface [polypeptide binding]; other site 754035002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002473 catalytic residue [active] 754035002474 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 754035002475 Predicted integral membrane protein [Function unknown]; Region: COG5616 754035002476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035002477 binding surface 754035002478 TPR motif; other site 754035002479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035002480 TPR motif; other site 754035002481 binding surface 754035002482 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 754035002483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035002484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035002485 ligand binding site [chemical binding]; other site 754035002486 flexible hinge region; other site 754035002487 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 754035002488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035002489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035002490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035002491 catalytic core [active] 754035002492 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 754035002493 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 754035002494 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 754035002495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035002496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035002497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035002498 Walker A/P-loop; other site 754035002499 ATP binding site [chemical binding]; other site 754035002500 Q-loop/lid; other site 754035002501 ABC transporter signature motif; other site 754035002502 Walker B; other site 754035002503 D-loop; other site 754035002504 H-loop/switch region; other site 754035002505 glucokinase; Provisional; Region: glk; PRK00292 754035002506 glucokinase, proteobacterial type; Region: glk; TIGR00749 754035002507 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 754035002508 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 754035002509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035002510 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 754035002511 putative NAD(P) binding site [chemical binding]; other site 754035002512 epoxyqueuosine reductase; Region: TIGR00276 754035002513 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 754035002514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035002515 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754035002516 C-terminal domain interface [polypeptide binding]; other site 754035002517 GSH binding site (G-site) [chemical binding]; other site 754035002518 dimer interface [polypeptide binding]; other site 754035002519 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035002520 N-terminal domain interface [polypeptide binding]; other site 754035002521 dimer interface [polypeptide binding]; other site 754035002522 substrate binding pocket (H-site) [chemical binding]; other site 754035002523 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 754035002524 hypothetical protein; Reviewed; Region: PRK12497 754035002525 Predicted methyltransferases [General function prediction only]; Region: COG0313 754035002526 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 754035002527 putative SAM binding site [chemical binding]; other site 754035002528 putative homodimer interface [polypeptide binding]; other site 754035002529 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 754035002530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754035002531 homodimer interface [polypeptide binding]; other site 754035002532 substrate-cofactor binding pocket; other site 754035002533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002534 catalytic residue [active] 754035002535 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754035002536 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754035002537 dimer interface [polypeptide binding]; other site 754035002538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002539 catalytic residue [active] 754035002540 FOG: CBS domain [General function prediction only]; Region: COG0517 754035002541 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 754035002542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 754035002543 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 754035002544 Predicted transcriptional regulator [Transcription]; Region: COG1959 754035002545 Transcriptional regulator; Region: Rrf2; pfam02082 754035002546 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 754035002547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035002548 substrate binding pocket [chemical binding]; other site 754035002549 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 754035002550 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 754035002551 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035002552 Walker A/P-loop; other site 754035002553 ATP binding site [chemical binding]; other site 754035002554 Q-loop/lid; other site 754035002555 ABC transporter signature motif; other site 754035002556 Walker B; other site 754035002557 D-loop; other site 754035002558 H-loop/switch region; other site 754035002559 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002561 dimer interface [polypeptide binding]; other site 754035002562 conserved gate region; other site 754035002563 putative PBP binding loops; other site 754035002564 ABC-ATPase subunit interface; other site 754035002565 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 754035002566 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 754035002567 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 754035002568 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 754035002569 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 754035002570 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035002571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035002572 non-specific DNA binding site [nucleotide binding]; other site 754035002573 salt bridge; other site 754035002574 sequence-specific DNA binding site [nucleotide binding]; other site 754035002575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 754035002576 Smr domain; Region: Smr; pfam01713 754035002577 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 754035002578 MltA specific insert domain; Region: MltA; smart00925 754035002579 3D domain; Region: 3D; pfam06725 754035002580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 754035002581 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 754035002582 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 754035002583 SecA binding site; other site 754035002584 Preprotein binding site; other site 754035002585 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035002586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035002587 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 754035002588 DNA methylase; Region: N6_N4_Mtase; pfam01555 754035002589 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 754035002590 GTP-binding protein LepA; Provisional; Region: PRK05433 754035002591 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 754035002592 G1 box; other site 754035002593 putative GEF interaction site [polypeptide binding]; other site 754035002594 GTP/Mg2+ binding site [chemical binding]; other site 754035002595 Switch I region; other site 754035002596 G2 box; other site 754035002597 G3 box; other site 754035002598 Switch II region; other site 754035002599 G4 box; other site 754035002600 G5 box; other site 754035002601 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 754035002602 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 754035002603 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 754035002604 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035002605 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 754035002606 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 754035002607 methionine sulfoxide reductase A; Provisional; Region: PRK13014 754035002608 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 754035002609 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 754035002610 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 754035002611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754035002612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754035002613 Walker A/P-loop; other site 754035002614 ATP binding site [chemical binding]; other site 754035002615 Q-loop/lid; other site 754035002616 ABC transporter signature motif; other site 754035002617 Walker B; other site 754035002618 D-loop; other site 754035002619 H-loop/switch region; other site 754035002620 ABC-2 type transporter; Region: ABC2_membrane; cl17235 754035002621 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 754035002622 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 754035002623 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 754035002624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035002625 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 754035002626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035002627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035002628 active site 754035002629 phosphorylation site [posttranslational modification] 754035002630 intermolecular recognition site; other site 754035002631 dimerization interface [polypeptide binding]; other site 754035002632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035002633 DNA binding residues [nucleotide binding] 754035002634 dimerization interface [polypeptide binding]; other site 754035002635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754035002636 Histidine kinase; Region: HisKA_3; pfam07730 754035002637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035002638 ATP binding site [chemical binding]; other site 754035002639 Mg2+ binding site [ion binding]; other site 754035002640 G-X-G motif; other site 754035002641 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 754035002642 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754035002643 active site 754035002644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 754035002645 sequence-specific DNA binding site [nucleotide binding]; other site 754035002646 salt bridge; other site 754035002647 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 754035002648 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 754035002649 Sulfate transporter family; Region: Sulfate_transp; pfam00916 754035002650 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 754035002651 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 754035002652 active site 754035002653 DNA binding site [nucleotide binding] 754035002654 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 754035002655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035002656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035002657 non-specific DNA binding site [nucleotide binding]; other site 754035002658 salt bridge; other site 754035002659 sequence-specific DNA binding site [nucleotide binding]; other site 754035002660 CHAD domain; Region: CHAD; pfam05235 754035002661 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 754035002662 putative active site [active] 754035002663 putative metal binding residues [ion binding]; other site 754035002664 signature motif; other site 754035002665 putative dimer interface [polypeptide binding]; other site 754035002666 putative phosphate binding site [ion binding]; other site 754035002667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035002668 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 754035002669 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 754035002670 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035002671 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754035002672 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754035002673 Walker A/P-loop; other site 754035002674 ATP binding site [chemical binding]; other site 754035002675 Q-loop/lid; other site 754035002676 ABC transporter signature motif; other site 754035002677 Walker B; other site 754035002678 D-loop; other site 754035002679 H-loop/switch region; other site 754035002680 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 754035002681 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 754035002682 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754035002683 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754035002684 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 754035002685 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754035002686 tetramer interface [polypeptide binding]; other site 754035002687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002688 catalytic residue [active] 754035002689 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 754035002690 diiron binding motif [ion binding]; other site 754035002691 Uncharacterized conserved protein [Function unknown]; Region: COG1633 754035002692 CCC1-related protein family; Region: CCC1_like_1; cd02437 754035002693 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 754035002694 NIPSNAP; Region: NIPSNAP; pfam07978 754035002695 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035002696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035002697 dimerization interface [polypeptide binding]; other site 754035002698 putative DNA binding site [nucleotide binding]; other site 754035002699 putative Zn2+ binding site [ion binding]; other site 754035002700 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 754035002701 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 754035002702 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 754035002703 active site 754035002704 DNA binding site [nucleotide binding] 754035002705 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 754035002706 DNA binding site [nucleotide binding] 754035002707 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 754035002708 nucleotide binding site [chemical binding]; other site 754035002709 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 754035002710 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 754035002711 putative DNA binding site [nucleotide binding]; other site 754035002712 putative homodimer interface [polypeptide binding]; other site 754035002713 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 754035002714 dimerization interface [polypeptide binding]; other site 754035002715 metal binding site [ion binding]; metal-binding site 754035002716 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 754035002717 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 754035002718 DctM-like transporters; Region: DctM; pfam06808 754035002719 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 754035002720 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 754035002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 754035002722 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 754035002723 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035002724 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 754035002725 C-terminal domain interface [polypeptide binding]; other site 754035002726 GSH binding site (G-site) [chemical binding]; other site 754035002727 dimer interface [polypeptide binding]; other site 754035002728 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 754035002729 dimer interface [polypeptide binding]; other site 754035002730 substrate binding pocket (H-site) [chemical binding]; other site 754035002731 N-terminal domain interface [polypeptide binding]; other site 754035002732 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754035002733 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754035002734 dimer interface [polypeptide binding]; other site 754035002735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035002736 catalytic residue [active] 754035002737 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035002738 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 754035002739 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 754035002740 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 754035002741 ribonuclease PH; Reviewed; Region: rph; PRK00173 754035002742 Ribonuclease PH; Region: RNase_PH_bact; cd11362 754035002743 hexamer interface [polypeptide binding]; other site 754035002744 active site 754035002745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 754035002746 putative metal binding site [ion binding]; other site 754035002747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035002748 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 754035002749 active site 754035002750 dimerization interface [polypeptide binding]; other site 754035002751 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 754035002752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035002753 FeS/SAM binding site; other site 754035002754 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 754035002755 HemN C-terminal domain; Region: HemN_C; pfam06969 754035002756 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 754035002757 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 754035002758 active site 754035002759 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035002760 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035002761 conserved cys residue [active] 754035002762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035002763 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035002764 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035002765 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035002766 active site 754035002767 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 754035002768 Isochorismatase family; Region: Isochorismatase; pfam00857 754035002769 catalytic triad [active] 754035002770 conserved cis-peptide bond; other site 754035002771 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 754035002772 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 754035002773 active site 754035002774 catalytic site [active] 754035002775 substrate binding site [chemical binding]; other site 754035002776 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 754035002777 dephospho-CoA kinase; Region: TIGR00152 754035002778 CoA-binding site [chemical binding]; other site 754035002779 ATP-binding [chemical binding]; other site 754035002780 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 754035002781 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 754035002782 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 754035002783 shikimate binding site; other site 754035002784 NAD(P) binding site [chemical binding]; other site 754035002785 Maf-like protein; Reviewed; Region: PRK00078 754035002786 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 754035002787 active site 754035002788 dimer interface [polypeptide binding]; other site 754035002789 PEP synthetase regulatory protein; Provisional; Region: PRK05339 754035002790 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 754035002791 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 754035002792 substrate binding site [chemical binding]; other site 754035002793 active site 754035002794 Predicted membrane protein [Function unknown]; Region: COG1981 754035002795 transcription termination factor Rho; Provisional; Region: rho; PRK09376 754035002796 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 754035002797 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 754035002798 RNA binding site [nucleotide binding]; other site 754035002799 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 754035002800 multimer interface [polypeptide binding]; other site 754035002801 Walker A motif; other site 754035002802 ATP binding site [chemical binding]; other site 754035002803 Walker B motif; other site 754035002804 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 754035002805 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 754035002806 catalytic residues [active] 754035002807 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 754035002808 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 754035002809 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 754035002810 G1 box; other site 754035002811 GTP/Mg2+ binding site [chemical binding]; other site 754035002812 G2 box; other site 754035002813 Switch I region; other site 754035002814 G3 box; other site 754035002815 Switch II region; other site 754035002816 G4 box; other site 754035002817 G5 box; other site 754035002818 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 754035002819 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 754035002820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035002821 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 754035002822 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 754035002823 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 754035002824 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 754035002825 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754035002826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035002827 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754035002828 Magnesium ion binding site [ion binding]; other site 754035002829 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754035002830 ParB-like nuclease domain; Region: ParBc; pfam02195 754035002831 KorB domain; Region: KorB; pfam08535 754035002832 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 754035002833 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 754035002834 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 754035002835 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 754035002836 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 754035002837 tetramer interface [polypeptide binding]; other site 754035002838 TPP-binding site [chemical binding]; other site 754035002839 heterodimer interface [polypeptide binding]; other site 754035002840 phosphorylation loop region [posttranslational modification] 754035002841 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 754035002842 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 754035002843 alpha subunit interface [polypeptide binding]; other site 754035002844 TPP binding site [chemical binding]; other site 754035002845 heterodimer interface [polypeptide binding]; other site 754035002846 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754035002847 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 754035002848 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035002849 E3 interaction surface; other site 754035002850 lipoyl attachment site [posttranslational modification]; other site 754035002851 e3 binding domain; Region: E3_binding; pfam02817 754035002852 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754035002853 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 754035002854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035002855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035002856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035002857 Helix-turn-helix domain; Region: HTH_28; pfam13518 754035002858 Winged helix-turn helix; Region: HTH_29; pfam13551 754035002859 Homeodomain-like domain; Region: HTH_32; pfam13565 754035002860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754035002861 Integrase core domain; Region: rve; pfam00665 754035002862 Integrase core domain; Region: rve_3; pfam13683 754035002863 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 754035002864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035002865 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035002866 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 754035002867 AsnC family; Region: AsnC_trans_reg; pfam01037 754035002868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035002869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035002870 dimer interface [polypeptide binding]; other site 754035002871 phosphorylation site [posttranslational modification] 754035002872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035002873 ATP binding site [chemical binding]; other site 754035002874 Mg2+ binding site [ion binding]; other site 754035002875 G-X-G motif; other site 754035002876 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 754035002877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035002878 active site 754035002879 phosphorylation site [posttranslational modification] 754035002880 intermolecular recognition site; other site 754035002881 dimerization interface [polypeptide binding]; other site 754035002882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035002883 DNA binding site [nucleotide binding] 754035002884 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 754035002885 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 754035002886 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 754035002887 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 754035002888 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 754035002889 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035002890 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754035002891 homotrimer interaction site [polypeptide binding]; other site 754035002892 putative active site [active] 754035002893 Predicted amidohydrolase [General function prediction only]; Region: COG3964 754035002894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035002895 active site 754035002896 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035002897 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 754035002898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 754035002899 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 754035002900 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035002901 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035002902 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035002903 putative active site [active] 754035002904 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035002905 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035002906 Walker A/P-loop; other site 754035002907 ATP binding site [chemical binding]; other site 754035002908 Q-loop/lid; other site 754035002909 ABC transporter signature motif; other site 754035002910 Walker B; other site 754035002911 D-loop; other site 754035002912 H-loop/switch region; other site 754035002913 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035002914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035002915 dimer interface [polypeptide binding]; other site 754035002916 conserved gate region; other site 754035002917 putative PBP binding loops; other site 754035002918 ABC-ATPase subunit interface; other site 754035002919 NMT1/THI5 like; Region: NMT1; pfam09084 754035002920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035002921 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035002922 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 754035002923 Amidase; Region: Amidase; pfam01425 754035002924 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035002925 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035002926 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035002927 active site 754035002928 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 754035002929 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 754035002930 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 754035002931 Phage Tail Collar Domain; Region: Collar; pfam07484 754035002932 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 754035002933 Phage Tail Collar Domain; Region: Collar; pfam07484 754035002934 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 754035002935 Phage Tail Collar Domain; Region: Collar; pfam07484 754035002936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035002937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035002938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035002939 Coenzyme A binding pocket [chemical binding]; other site 754035002940 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 754035002941 SapC; Region: SapC; pfam07277 754035002942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754035002943 active site 754035002944 DNA binding site [nucleotide binding] 754035002945 Int/Topo IB signature motif; other site 754035002946 Protein of unknown function (DUF867); Region: DUF867; pfam05908 754035002947 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035002948 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 754035002949 additional DNA contacts [nucleotide binding]; other site 754035002950 mismatch recognition site; other site 754035002951 active site 754035002952 zinc binding site [ion binding]; other site 754035002953 DNA intercalation site [nucleotide binding]; other site 754035002954 AAA-like domain; Region: AAA_10; pfam12846 754035002955 Domain of unknown function DUF87; Region: DUF87; pfam01935 754035002956 Zeta toxin; Region: Zeta_toxin; pfam06414 754035002957 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 754035002958 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754035002959 cofactor binding site; other site 754035002960 DNA binding site [nucleotide binding] 754035002961 substrate interaction site [chemical binding]; other site 754035002962 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754035002963 Uncharacterized conserved protein [Function unknown]; Region: COG4544 754035002964 DNA Polymerase Y-family; Region: PolY_like; cd03468 754035002965 active site 754035002966 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 754035002967 DNA binding site [nucleotide binding] 754035002968 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 754035002969 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 754035002970 putative active site [active] 754035002971 putative PHP Thumb interface [polypeptide binding]; other site 754035002972 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754035002973 generic binding surface I; other site 754035002974 generic binding surface II; other site 754035002975 Domain of unknown function (DUF955); Region: DUF955; pfam06114 754035002976 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 754035002977 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 754035002978 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 754035002979 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 754035002980 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 754035002981 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 754035002982 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 754035002983 ATP binding site [chemical binding]; other site 754035002984 substrate interface [chemical binding]; other site 754035002985 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754035002986 trimer interface [polypeptide binding]; other site 754035002987 active site 754035002988 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 754035002989 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 754035002990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035002991 active site 754035002992 motif I; other site 754035002993 motif II; other site 754035002994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035002995 AAA-like domain; Region: AAA_10; pfam12846 754035002996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035002997 Walker B; other site 754035002998 D-loop; other site 754035002999 H-loop/switch region; other site 754035003000 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 754035003001 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 754035003002 conjugal transfer protein TrbL; Provisional; Region: PRK13875 754035003003 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 754035003004 conjugal transfer protein TrbF; Provisional; Region: PRK13872 754035003005 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 754035003006 VirB7 interaction site; other site 754035003007 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 754035003008 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 754035003009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035003010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035003011 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 754035003012 dimerization interface [polypeptide binding]; other site 754035003013 substrate binding pocket [chemical binding]; other site 754035003014 Autoinducer synthetase; Region: Autoind_synth; cl17404 754035003015 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035003016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035003017 DNA binding residues [nucleotide binding] 754035003018 dimerization interface [polypeptide binding]; other site 754035003019 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 754035003020 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035003021 active site 754035003022 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035003023 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035003024 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035003025 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035003026 Walker A/P-loop; other site 754035003027 ATP binding site [chemical binding]; other site 754035003028 Q-loop/lid; other site 754035003029 ABC transporter signature motif; other site 754035003030 Walker B; other site 754035003031 D-loop; other site 754035003032 H-loop/switch region; other site 754035003033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035003034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003035 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003036 TM-ABC transporter signature motif; other site 754035003037 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003038 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003039 TM-ABC transporter signature motif; other site 754035003040 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035003041 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035003042 FAD binding site [chemical binding]; other site 754035003043 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 754035003044 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 754035003045 homodimer interface [polypeptide binding]; other site 754035003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035003047 catalytic residue [active] 754035003048 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754035003049 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 754035003050 dimerization interface [polypeptide binding]; other site 754035003051 ligand binding site [chemical binding]; other site 754035003052 NADP binding site [chemical binding]; other site 754035003053 catalytic site [active] 754035003054 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 754035003055 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 754035003056 dimer interface [polypeptide binding]; other site 754035003057 active site 754035003058 glycine-pyridoxal phosphate binding site [chemical binding]; other site 754035003059 folate binding site [chemical binding]; other site 754035003060 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 754035003061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003062 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003063 TM-ABC transporter signature motif; other site 754035003064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003065 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003066 TM-ABC transporter signature motif; other site 754035003067 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035003068 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035003069 Walker A/P-loop; other site 754035003070 ATP binding site [chemical binding]; other site 754035003071 Q-loop/lid; other site 754035003072 ABC transporter signature motif; other site 754035003073 Walker B; other site 754035003074 D-loop; other site 754035003075 H-loop/switch region; other site 754035003076 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035003077 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035003078 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 754035003079 putative ligand binding site [chemical binding]; other site 754035003080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035003081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035003082 DNA-binding site [nucleotide binding]; DNA binding site 754035003083 FCD domain; Region: FCD; pfam07729 754035003084 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035003085 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035003086 hydrophobic ligand binding site; other site 754035003087 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035003088 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035003089 hydrophobic ligand binding site; other site 754035003090 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035003091 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035003092 [2Fe-2S] cluster binding site [ion binding]; other site 754035003093 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 754035003094 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 754035003095 FMN-binding pocket [chemical binding]; other site 754035003096 flavin binding motif; other site 754035003097 phosphate binding motif [ion binding]; other site 754035003098 beta-alpha-beta structure motif; other site 754035003099 NAD binding pocket [chemical binding]; other site 754035003100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035003101 catalytic loop [active] 754035003102 iron binding site [ion binding]; other site 754035003103 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 754035003104 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035003105 putative C-terminal domain interface [polypeptide binding]; other site 754035003106 putative GSH binding site (G-site) [chemical binding]; other site 754035003107 putative dimer interface [polypeptide binding]; other site 754035003108 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 754035003109 putative N-terminal domain interface [polypeptide binding]; other site 754035003110 putative dimer interface [polypeptide binding]; other site 754035003111 putative substrate binding pocket (H-site) [chemical binding]; other site 754035003112 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 754035003113 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 754035003114 substrate binding site [chemical binding]; other site 754035003115 catalytic Zn binding site [ion binding]; other site 754035003116 NAD binding site [chemical binding]; other site 754035003117 structural Zn binding site [ion binding]; other site 754035003118 dimer interface [polypeptide binding]; other site 754035003119 S-formylglutathione hydrolase; Region: PLN02442 754035003120 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 754035003121 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 754035003122 nudix motif; other site 754035003123 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035003124 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035003125 conserved cys residue [active] 754035003126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035003127 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 754035003128 putative deacylase active site [active] 754035003129 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 754035003130 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754035003131 catalytic residues [active] 754035003132 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 754035003133 Uncharacterized conserved protein [Function unknown]; Region: COG2835 754035003134 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 754035003135 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035003136 catalytic residues [active] 754035003137 central insert; other site 754035003138 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 754035003139 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 754035003140 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 754035003141 Walker A/P-loop; other site 754035003142 ATP binding site [chemical binding]; other site 754035003143 Q-loop/lid; other site 754035003144 ABC transporter signature motif; other site 754035003145 Walker B; other site 754035003146 D-loop; other site 754035003147 H-loop/switch region; other site 754035003148 aconitate hydratase; Validated; Region: PRK09277 754035003149 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 754035003150 substrate binding site [chemical binding]; other site 754035003151 ligand binding site [chemical binding]; other site 754035003152 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 754035003153 substrate binding site [chemical binding]; other site 754035003154 Uncharacterized secreted protein [Function unknown]; Region: COG5429 754035003155 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035003156 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035003157 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035003158 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 754035003159 Walker A/P-loop; other site 754035003160 ATP binding site [chemical binding]; other site 754035003161 Q-loop/lid; other site 754035003162 ABC transporter signature motif; other site 754035003163 Walker B; other site 754035003164 D-loop; other site 754035003165 H-loop/switch region; other site 754035003166 TOBE domain; Region: TOBE_2; pfam08402 754035003167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035003168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003169 dimer interface [polypeptide binding]; other site 754035003170 conserved gate region; other site 754035003171 putative PBP binding loops; other site 754035003172 ABC-ATPase subunit interface; other site 754035003173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003174 dimer interface [polypeptide binding]; other site 754035003175 conserved gate region; other site 754035003176 putative PBP binding loops; other site 754035003177 ABC-ATPase subunit interface; other site 754035003178 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035003179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035003180 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 754035003181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035003182 non-specific DNA binding site [nucleotide binding]; other site 754035003183 salt bridge; other site 754035003184 sequence-specific DNA binding site [nucleotide binding]; other site 754035003185 Cupin domain; Region: Cupin_2; pfam07883 754035003186 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 754035003187 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 754035003188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035003189 Coenzyme A binding pocket [chemical binding]; other site 754035003190 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 754035003191 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 754035003192 ybhL leader; Mesau_00984 754035003193 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 754035003194 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 754035003195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754035003196 Walker A/P-loop; other site 754035003197 ATP binding site [chemical binding]; other site 754035003198 Q-loop/lid; other site 754035003199 ABC transporter signature motif; other site 754035003200 Walker B; other site 754035003201 D-loop; other site 754035003202 H-loop/switch region; other site 754035003203 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 754035003204 active site 754035003205 catalytic triad [active] 754035003206 oxyanion hole [active] 754035003207 switch loop; other site 754035003208 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 754035003209 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 754035003210 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 754035003211 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 754035003212 Low molecular weight phosphatase family; Region: LMWPc; cd00115 754035003213 active site 754035003214 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 754035003215 aromatic arch; other site 754035003216 DCoH dimer interaction site [polypeptide binding]; other site 754035003217 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 754035003218 DCoH tetramer interaction site [polypeptide binding]; other site 754035003219 substrate binding site [chemical binding]; other site 754035003220 Uncharacterized conserved protein [Function unknown]; Region: COG3339 754035003221 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 754035003222 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754035003223 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 754035003224 putative ion selectivity filter; other site 754035003225 putative pore gating glutamate residue; other site 754035003226 putative H+/Cl- coupling transport residue; other site 754035003227 Domain of unknown function (DUF305); Region: DUF305; cl17794 754035003228 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 754035003229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035003230 FeS/SAM binding site; other site 754035003231 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035003232 argininosuccinate synthase; Provisional; Region: PRK13820 754035003233 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 754035003234 ANP binding site [chemical binding]; other site 754035003235 Substrate Binding Site II [chemical binding]; other site 754035003236 Substrate Binding Site I [chemical binding]; other site 754035003237 Transglycosylase SLT domain; Region: SLT_2; pfam13406 754035003238 murein hydrolase B; Provisional; Region: PRK10760; cl17906 754035003239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 754035003240 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 754035003241 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 754035003242 Bacterial SH3 domain; Region: SH3_3; pfam08239 754035003243 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 754035003244 CAAX protease self-immunity; Region: Abi; pfam02517 754035003245 signal recognition particle protein; Provisional; Region: PRK10867 754035003246 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 754035003247 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754035003248 P loop; other site 754035003249 GTP binding site [chemical binding]; other site 754035003250 Signal peptide binding domain; Region: SRP_SPB; pfam02978 754035003251 chorismate mutase; Provisional; Region: PRK09239 754035003252 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 754035003253 DoxX-like family; Region: DoxX_2; pfam13564 754035003254 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 754035003255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 754035003256 ACT domain; Region: ACT_3; pfam10000 754035003257 Family description; Region: ACT_7; pfam13840 754035003258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035003259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035003260 Coenzyme A binding pocket [chemical binding]; other site 754035003261 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 754035003262 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754035003263 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754035003264 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 754035003265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754035003266 ATP binding site [chemical binding]; other site 754035003267 putative Mg++ binding site [ion binding]; other site 754035003268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035003269 nucleotide binding region [chemical binding]; other site 754035003270 ATP-binding site [chemical binding]; other site 754035003271 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 754035003272 RNA binding site [nucleotide binding]; other site 754035003273 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754035003274 RNA binding site [nucleotide binding]; other site 754035003275 Predicted membrane protein [Function unknown]; Region: COG3152 754035003276 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035003277 hydrophobic ligand binding site; other site 754035003278 MarR family; Region: MarR; pfam01047 754035003279 tartrate dehydrogenase; Region: TTC; TIGR02089 754035003280 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 754035003281 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 754035003282 dimer interface [polypeptide binding]; other site 754035003283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035003284 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 754035003285 homotrimer interaction site [polypeptide binding]; other site 754035003286 putative active site [active] 754035003287 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035003288 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 754035003289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035003290 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035003291 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 754035003292 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 754035003293 substrate binding site [chemical binding]; other site 754035003294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035003295 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035003296 Coenzyme A binding pocket [chemical binding]; other site 754035003297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035003298 dimerization interface [polypeptide binding]; other site 754035003299 putative DNA binding site [nucleotide binding]; other site 754035003300 putative Zn2+ binding site [ion binding]; other site 754035003301 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 754035003302 putative hydrophobic ligand binding site [chemical binding]; other site 754035003303 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035003304 hydrophobic ligand binding site; other site 754035003305 Protein of unknown function DUF72; Region: DUF72; pfam01904 754035003306 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035003307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035003308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035003309 dimerization interface [polypeptide binding]; other site 754035003310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035003311 dimer interface [polypeptide binding]; other site 754035003312 phosphorylation site [posttranslational modification] 754035003313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035003314 ATP binding site [chemical binding]; other site 754035003315 Mg2+ binding site [ion binding]; other site 754035003316 G-X-G motif; other site 754035003317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035003318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035003319 active site 754035003320 phosphorylation site [posttranslational modification] 754035003321 intermolecular recognition site; other site 754035003322 dimerization interface [polypeptide binding]; other site 754035003323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035003324 DNA binding site [nucleotide binding] 754035003325 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 754035003326 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 754035003327 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 754035003328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035003329 sequence-specific DNA binding site [nucleotide binding]; other site 754035003330 salt bridge; other site 754035003331 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 754035003332 Uncharacterized conserved protein [Function unknown]; Region: COG4544 754035003333 DNA Polymerase Y-family; Region: PolY_like; cd03468 754035003334 active site 754035003335 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 754035003336 DNA binding site [nucleotide binding] 754035003337 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 754035003338 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 754035003339 putative active site [active] 754035003340 putative PHP Thumb interface [polypeptide binding]; other site 754035003341 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754035003342 generic binding surface I; other site 754035003343 generic binding surface II; other site 754035003344 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 754035003345 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 754035003346 active site 1 [active] 754035003347 dimer interface [polypeptide binding]; other site 754035003348 hexamer interface [polypeptide binding]; other site 754035003349 active site 2 [active] 754035003350 Predicted ATPase [General function prediction only]; Region: COG1485 754035003351 Protease inhibitor Inh; Region: Inh; pfam02974 754035003352 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 754035003353 active site 754035003354 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754035003355 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 754035003356 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 754035003357 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754035003358 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754035003359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754035003360 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 754035003361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035003362 FeS/SAM binding site; other site 754035003363 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 754035003364 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 754035003365 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035003366 intracellular septation protein A; Reviewed; Region: PRK00259 754035003367 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 754035003368 Predicted flavoprotein [General function prediction only]; Region: COG0431 754035003369 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035003370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035003371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035003372 Coenzyme A binding pocket [chemical binding]; other site 754035003373 malate dehydrogenase; Reviewed; Region: PRK06223 754035003374 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 754035003375 NAD(P) binding site [chemical binding]; other site 754035003376 dimer interface [polypeptide binding]; other site 754035003377 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754035003378 substrate binding site [chemical binding]; other site 754035003379 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 754035003380 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 754035003381 CoA-ligase; Region: Ligase_CoA; pfam00549 754035003382 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 754035003383 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 754035003384 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 754035003385 CoA binding domain; Region: CoA_binding; smart00881 754035003386 CoA-ligase; Region: Ligase_CoA; pfam00549 754035003387 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 754035003388 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 754035003389 TPP-binding site [chemical binding]; other site 754035003390 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 754035003391 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 754035003392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035003393 E3 interaction surface; other site 754035003394 lipoyl attachment site [posttranslational modification]; other site 754035003395 e3 binding domain; Region: E3_binding; pfam02817 754035003396 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754035003397 short chain dehydrogenase; Provisional; Region: PRK06123 754035003398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035003399 NAD(P) binding site [chemical binding]; other site 754035003400 active site 754035003401 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 754035003402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035003403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035003404 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 754035003406 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 754035003407 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754035003408 active site 754035003409 DNA binding site [nucleotide binding] 754035003410 Int/Topo IB signature motif; other site 754035003411 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 754035003412 RimM N-terminal domain; Region: RimM; pfam01782 754035003413 PRC-barrel domain; Region: PRC; pfam05239 754035003414 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 754035003415 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 754035003416 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 754035003417 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 754035003418 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035003419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035003420 putative Zn2+ binding site [ion binding]; other site 754035003421 putative DNA binding site [nucleotide binding]; other site 754035003422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035003423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035003424 substrate binding pocket [chemical binding]; other site 754035003425 membrane-bound complex binding site; other site 754035003426 hinge residues; other site 754035003427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003428 dimer interface [polypeptide binding]; other site 754035003429 conserved gate region; other site 754035003430 putative PBP binding loops; other site 754035003431 ABC-ATPase subunit interface; other site 754035003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035003433 S-adenosylmethionine binding site [chemical binding]; other site 754035003434 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 754035003435 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 754035003436 substrate binding site [chemical binding]; other site 754035003437 ligand binding site [chemical binding]; other site 754035003438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035003439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035003440 metal binding site [ion binding]; metal-binding site 754035003441 active site 754035003442 I-site; other site 754035003443 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035003444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035003445 metal binding site [ion binding]; metal-binding site 754035003446 active site 754035003447 I-site; other site 754035003448 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 754035003449 Iron-sulfur protein interface; other site 754035003450 proximal quinone binding site [chemical binding]; other site 754035003451 SdhD (CybS) interface [polypeptide binding]; other site 754035003452 proximal heme binding site [chemical binding]; other site 754035003453 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 754035003454 putative SdhC subunit interface [polypeptide binding]; other site 754035003455 putative proximal heme binding site [chemical binding]; other site 754035003456 putative Iron-sulfur protein interface [polypeptide binding]; other site 754035003457 putative proximal quinone binding site; other site 754035003458 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 754035003459 L-aspartate oxidase; Provisional; Region: PRK06175 754035003460 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754035003461 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 754035003462 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754035003463 Sulfatase; Region: Sulfatase; cl17466 754035003464 Protein of unknown function, DUF480; Region: DUF480; cl01209 754035003465 hypothetical protein; Provisional; Region: PRK11239 754035003466 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 754035003467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 754035003468 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 754035003469 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035003470 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 754035003471 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 754035003472 active site 754035003473 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 754035003474 catalytic triad [active] 754035003475 dimer interface [polypeptide binding]; other site 754035003476 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 754035003477 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754035003478 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 754035003479 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 754035003480 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 754035003481 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754035003482 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 754035003483 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 754035003484 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 754035003485 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 754035003486 putative catalytic site [active] 754035003487 putative phosphate binding site [ion binding]; other site 754035003488 active site 754035003489 metal binding site A [ion binding]; metal-binding site 754035003490 DNA binding site [nucleotide binding] 754035003491 putative AP binding site [nucleotide binding]; other site 754035003492 putative metal binding site B [ion binding]; other site 754035003493 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035003494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035003495 ligand binding site [chemical binding]; other site 754035003496 flexible hinge region; other site 754035003497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035003498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035003499 active site 754035003500 phosphorylation site [posttranslational modification] 754035003501 intermolecular recognition site; other site 754035003502 dimerization interface [polypeptide binding]; other site 754035003503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035003504 DNA binding site [nucleotide binding] 754035003505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 754035003506 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035003507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035003508 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035003509 dimerization interface [polypeptide binding]; other site 754035003510 substrate binding pocket [chemical binding]; other site 754035003511 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754035003512 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 754035003513 Predicted methyltransferase [General function prediction only]; Region: COG3897 754035003514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035003515 Uncharacterized conserved protein [Function unknown]; Region: COG2947 754035003516 YciI-like protein; Reviewed; Region: PRK12865 754035003517 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 754035003518 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 754035003519 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 754035003520 UGMP family protein; Validated; Region: PRK09604 754035003521 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 754035003522 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 754035003523 domain interfaces; other site 754035003524 active site 754035003525 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 754035003526 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 754035003527 active site 754035003528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 754035003529 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 754035003530 HemY protein N-terminus; Region: HemY_N; pfam07219 754035003531 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 754035003532 putative metal binding site [ion binding]; other site 754035003533 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 754035003534 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 754035003535 catalytic triad [active] 754035003536 enterobactin exporter EntS; Provisional; Region: PRK10489 754035003537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035003538 putative substrate translocation pore; other site 754035003539 transaminase; Validated; Region: PRK07324 754035003540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035003542 homodimer interface [polypeptide binding]; other site 754035003543 catalytic residue [active] 754035003544 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 754035003545 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035003546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035003547 nucleotide binding site [chemical binding]; other site 754035003548 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 754035003549 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 754035003550 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 754035003551 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 754035003552 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035003553 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 754035003554 Domain interface; other site 754035003555 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 754035003556 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 754035003557 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035003558 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 754035003559 putative ligand binding site [chemical binding]; other site 754035003560 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035003561 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035003562 Walker A/P-loop; other site 754035003563 ATP binding site [chemical binding]; other site 754035003564 Q-loop/lid; other site 754035003565 ABC transporter signature motif; other site 754035003566 Walker B; other site 754035003567 D-loop; other site 754035003568 H-loop/switch region; other site 754035003569 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035003570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035003572 TM-ABC transporter signature motif; other site 754035003573 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035003575 TM-ABC transporter signature motif; other site 754035003576 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 754035003577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035003578 substrate binding site [chemical binding]; other site 754035003579 oxyanion hole (OAH) forming residues; other site 754035003580 trimer interface [polypeptide binding]; other site 754035003581 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035003582 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035003583 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035003584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035003585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035003586 DNA binding residues [nucleotide binding] 754035003587 dimerization interface [polypeptide binding]; other site 754035003588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035003589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035003590 Walker A/P-loop; other site 754035003591 ATP binding site [chemical binding]; other site 754035003592 Q-loop/lid; other site 754035003593 ABC transporter signature motif; other site 754035003594 Walker B; other site 754035003595 D-loop; other site 754035003596 H-loop/switch region; other site 754035003597 TOBE domain; Region: TOBE_2; pfam08402 754035003598 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035003599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035003600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003601 dimer interface [polypeptide binding]; other site 754035003602 conserved gate region; other site 754035003603 putative PBP binding loops; other site 754035003604 ABC-ATPase subunit interface; other site 754035003605 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035003606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003607 ABC-ATPase subunit interface; other site 754035003608 short chain dehydrogenase; Provisional; Region: PRK06138 754035003609 classical (c) SDRs; Region: SDR_c; cd05233 754035003610 NAD(P) binding site [chemical binding]; other site 754035003611 active site 754035003612 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754035003613 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035003614 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035003615 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035003616 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 754035003617 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 754035003618 Bacterial transcriptional regulator; Region: IclR; pfam01614 754035003619 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 754035003620 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 754035003621 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 754035003622 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754035003623 dimer interface [polypeptide binding]; other site 754035003624 active site 754035003625 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035003626 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 754035003627 putative ligand binding site [chemical binding]; other site 754035003628 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035003629 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035003630 Walker A/P-loop; other site 754035003631 ATP binding site [chemical binding]; other site 754035003632 Q-loop/lid; other site 754035003633 ABC transporter signature motif; other site 754035003634 Walker B; other site 754035003635 D-loop; other site 754035003636 H-loop/switch region; other site 754035003637 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035003638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003639 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003640 TM-ABC transporter signature motif; other site 754035003641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035003642 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035003643 TM-ABC transporter signature motif; other site 754035003644 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035003645 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035003646 Isochorismatase family; Region: Isochorismatase; pfam00857 754035003647 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 754035003648 catalytic triad [active] 754035003649 conserved cis-peptide bond; other site 754035003650 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 754035003651 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754035003652 Walker A/P-loop; other site 754035003653 ATP binding site [chemical binding]; other site 754035003654 Q-loop/lid; other site 754035003655 ABC transporter signature motif; other site 754035003656 Walker B; other site 754035003657 D-loop; other site 754035003658 H-loop/switch region; other site 754035003659 tonB-system energizer ExbB; Region: exbB; TIGR02797 754035003660 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 754035003661 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 754035003662 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 754035003663 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 754035003664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035003665 non-specific DNA binding site [nucleotide binding]; other site 754035003666 salt bridge; other site 754035003667 sequence-specific DNA binding site [nucleotide binding]; other site 754035003668 YGGT family; Region: YGGT; pfam02325 754035003669 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 754035003670 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035003671 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035003672 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035003673 putative active site [active] 754035003674 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035003675 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035003676 Walker A/P-loop; other site 754035003677 ATP binding site [chemical binding]; other site 754035003678 Q-loop/lid; other site 754035003679 ABC transporter signature motif; other site 754035003680 Walker B; other site 754035003681 D-loop; other site 754035003682 H-loop/switch region; other site 754035003683 TOBE domain; Region: TOBE; pfam03459 754035003684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035003685 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 754035003686 NAD(P) binding site [chemical binding]; other site 754035003687 active site 754035003688 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035003689 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003691 conserved gate region; other site 754035003692 dimer interface [polypeptide binding]; other site 754035003693 putative PBP binding loops; other site 754035003694 ABC-ATPase subunit interface; other site 754035003695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035003696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035003697 dimer interface [polypeptide binding]; other site 754035003698 conserved gate region; other site 754035003699 ABC-ATPase subunit interface; other site 754035003700 Uncharacterized conserved protein [Function unknown]; Region: COG5476 754035003701 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 754035003702 MlrC C-terminus; Region: MlrC_C; pfam07171 754035003703 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 754035003704 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 754035003705 active site 754035003706 Zn binding site [ion binding]; other site 754035003707 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 754035003708 active site clefts [active] 754035003709 zinc binding site [ion binding]; other site 754035003710 dimer interface [polypeptide binding]; other site 754035003711 Protein of unknown function (DUF429); Region: DUF429; cl12046 754035003712 pyridoxamine kinase; Validated; Region: PRK05756 754035003713 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 754035003714 pyridoxal binding site [chemical binding]; other site 754035003715 dimer interface [polypeptide binding]; other site 754035003716 ATP binding site [chemical binding]; other site 754035003717 LemA family; Region: LemA; pfam04011 754035003718 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 754035003719 Repair protein; Region: Repair_PSII; pfam04536 754035003720 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 754035003721 Repair protein; Region: Repair_PSII; pfam04536 754035003722 Predicted membrane protein [Function unknown]; Region: COG3762 754035003723 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035003724 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 754035003725 dimer interface [polypeptide binding]; other site 754035003726 substrate binding site [chemical binding]; other site 754035003727 metal binding sites [ion binding]; metal-binding site 754035003728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035003729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035003730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035003731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035003732 putative substrate translocation pore; other site 754035003733 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 754035003734 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 754035003735 G1 box; other site 754035003736 putative GEF interaction site [polypeptide binding]; other site 754035003737 GTP/Mg2+ binding site [chemical binding]; other site 754035003738 Switch I region; other site 754035003739 G2 box; other site 754035003740 G3 box; other site 754035003741 Switch II region; other site 754035003742 G4 box; other site 754035003743 G5 box; other site 754035003744 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 754035003745 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 754035003746 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 754035003747 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035003748 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 754035003749 active sites [active] 754035003750 tetramer interface [polypeptide binding]; other site 754035003751 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 754035003752 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 754035003753 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 754035003754 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 754035003755 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 754035003756 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 754035003757 purine monophosphate binding site [chemical binding]; other site 754035003758 dimer interface [polypeptide binding]; other site 754035003759 putative catalytic residues [active] 754035003760 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 754035003761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 754035003762 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 754035003763 NusB family; Region: NusB; pfam01029 754035003764 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 754035003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035003766 S-adenosylmethionine binding site [chemical binding]; other site 754035003767 heat shock protein HtpX; Provisional; Region: PRK01345 754035003768 putative phosphatase; Provisional; Region: PRK11587 754035003769 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035003770 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 754035003771 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035003772 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 754035003773 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 754035003774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035003775 S-adenosylmethionine binding site [chemical binding]; other site 754035003776 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 754035003777 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 754035003778 MOSC domain; Region: MOSC; pfam03473 754035003779 acetyl-CoA synthetase; Provisional; Region: PRK00174 754035003780 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 754035003781 active site 754035003782 CoA binding site [chemical binding]; other site 754035003783 acyl-activating enzyme (AAE) consensus motif; other site 754035003784 AMP binding site [chemical binding]; other site 754035003785 acetate binding site [chemical binding]; other site 754035003786 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 754035003787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035003788 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035003789 active site 754035003790 catalytic tetrad [active] 754035003791 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035003792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035003793 putative substrate translocation pore; other site 754035003794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035003795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035003796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 754035003797 putative effector binding pocket; other site 754035003798 putative dimerization interface [polypeptide binding]; other site 754035003799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035003800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035003801 active site 754035003802 catalytic tetrad [active] 754035003803 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 754035003804 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035003805 catalytic residue [active] 754035003806 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 754035003807 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 754035003808 HIGH motif; other site 754035003809 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754035003810 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754035003811 active site 754035003812 KMSKS motif; other site 754035003813 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 754035003814 tRNA binding surface [nucleotide binding]; other site 754035003815 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 754035003816 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 754035003817 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754035003818 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 754035003819 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 754035003820 active site 754035003821 intersubunit interactions; other site 754035003822 catalytic residue [active] 754035003823 primosome assembly protein PriA; Validated; Region: PRK05580 754035003824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035003825 ATP binding site [chemical binding]; other site 754035003826 putative Mg++ binding site [ion binding]; other site 754035003827 helicase superfamily c-terminal domain; Region: HELICc; smart00490 754035003828 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 754035003829 oligomeric interface; other site 754035003830 putative active site [active] 754035003831 homodimer interface [polypeptide binding]; other site 754035003832 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 754035003833 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 754035003834 aspartate racemase; Region: asp_race; TIGR00035 754035003835 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 754035003836 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 754035003837 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 754035003838 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754035003839 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 754035003840 beta subunit interaction interface [polypeptide binding]; other site 754035003841 Walker A motif; other site 754035003842 ATP binding site [chemical binding]; other site 754035003843 Walker B motif; other site 754035003844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754035003845 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 754035003846 core domain interface [polypeptide binding]; other site 754035003847 delta subunit interface [polypeptide binding]; other site 754035003848 epsilon subunit interface [polypeptide binding]; other site 754035003849 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 754035003850 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754035003851 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 754035003852 alpha subunit interaction interface [polypeptide binding]; other site 754035003853 Walker A motif; other site 754035003854 ATP binding site [chemical binding]; other site 754035003855 Walker B motif; other site 754035003856 inhibitor binding site; inhibition site 754035003857 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754035003858 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 754035003859 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 754035003860 gamma subunit interface [polypeptide binding]; other site 754035003861 epsilon subunit interface [polypeptide binding]; other site 754035003862 LBP interface [polypeptide binding]; other site 754035003863 D-mannonate oxidoreductase; Provisional; Region: PRK15037 754035003864 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754035003865 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754035003866 glucuronate isomerase; Reviewed; Region: PRK02925 754035003867 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 754035003868 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 754035003869 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 754035003870 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 754035003871 DctM-like transporters; Region: DctM; pfam06808 754035003872 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 754035003873 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035003874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035003875 DNA-binding site [nucleotide binding]; DNA binding site 754035003876 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754035003877 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 754035003878 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 754035003879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035003880 NAD(P) binding site [chemical binding]; other site 754035003881 active site 754035003882 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035003883 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 754035003884 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 754035003885 NAD(P) binding site [chemical binding]; other site 754035003886 catalytic residues [active] 754035003887 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 754035003888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035003889 ATP binding site [chemical binding]; other site 754035003890 putative Mg++ binding site [ion binding]; other site 754035003891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035003892 nucleotide binding region [chemical binding]; other site 754035003893 ATP-binding site [chemical binding]; other site 754035003894 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 754035003895 HRDC domain; Region: HRDC; pfam00570 754035003896 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 754035003897 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 754035003898 putative active site [active] 754035003899 catalytic site [active] 754035003900 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 754035003901 putative active site [active] 754035003902 catalytic site [active] 754035003903 Low affinity iron permease; Region: Iron_permease; cl12096 754035003904 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 754035003905 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 754035003906 Uncharacterized conserved protein [Function unknown]; Region: COG3743 754035003907 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 754035003908 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 754035003909 putative catalytic site [active] 754035003910 putative metal binding site [ion binding]; other site 754035003911 putative phosphate binding site [ion binding]; other site 754035003912 GTPase CgtA; Reviewed; Region: obgE; PRK12299 754035003913 GTP1/OBG; Region: GTP1_OBG; pfam01018 754035003914 Obg GTPase; Region: Obg; cd01898 754035003915 G1 box; other site 754035003916 GTP/Mg2+ binding site [chemical binding]; other site 754035003917 Switch I region; other site 754035003918 G2 box; other site 754035003919 G3 box; other site 754035003920 Switch II region; other site 754035003921 G4 box; other site 754035003922 G5 box; other site 754035003923 gamma-glutamyl kinase; Provisional; Region: PRK05429 754035003924 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 754035003925 nucleotide binding site [chemical binding]; other site 754035003926 homotetrameric interface [polypeptide binding]; other site 754035003927 putative phosphate binding site [ion binding]; other site 754035003928 putative allosteric binding site; other site 754035003929 PUA domain; Region: PUA; pfam01472 754035003930 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 754035003931 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 754035003932 putative catalytic cysteine [active] 754035003933 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 754035003934 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 754035003935 active site 754035003936 (T/H)XGH motif; other site 754035003937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035003938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035003939 putative substrate translocation pore; other site 754035003940 Conserved TM helix; Region: TM_helix; pfam05552 754035003941 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754035003942 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 754035003943 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 754035003944 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 754035003945 Peptidase family M23; Region: Peptidase_M23; pfam01551 754035003946 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 754035003947 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 754035003948 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 754035003949 protein binding site [polypeptide binding]; other site 754035003950 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 754035003951 Catalytic dyad [active] 754035003952 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 754035003953 NodB motif; other site 754035003954 putative active site [active] 754035003955 putative catalytic site [active] 754035003956 Zn binding site [ion binding]; other site 754035003957 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 754035003958 putative active site [active] 754035003959 Ap4A binding site [chemical binding]; other site 754035003960 nudix motif; other site 754035003961 putative metal binding site [ion binding]; other site 754035003962 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 754035003963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 754035003964 active site 754035003965 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035003966 dimer interface [polypeptide binding]; other site 754035003967 substrate binding site [chemical binding]; other site 754035003968 catalytic residues [active] 754035003969 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 754035003970 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754035003971 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 754035003972 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 754035003973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035003974 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 754035003975 putative active site [active] 754035003976 catalytic site [active] 754035003977 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 754035003978 PLD-like domain; Region: PLDc_2; pfam13091 754035003979 putative active site [active] 754035003980 catalytic site [active] 754035003981 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 754035003982 primary metal binding site; other site 754035003983 catalytic residues [active] 754035003984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035003985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035003986 LysR substrate binding domain; Region: LysR_substrate; pfam03466 754035003987 dimerization interface [polypeptide binding]; other site 754035003988 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 754035003989 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 754035003990 tetrameric interface [polypeptide binding]; other site 754035003991 NAD binding site [chemical binding]; other site 754035003992 catalytic residues [active] 754035003993 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035003994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035003995 DNA-binding site [nucleotide binding]; DNA binding site 754035003996 FCD domain; Region: FCD; pfam07729 754035003997 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 754035003998 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 754035003999 inhibitor site; inhibition site 754035004000 active site 754035004001 dimer interface [polypeptide binding]; other site 754035004002 catalytic residue [active] 754035004003 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035004004 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 754035004005 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 754035004006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035004007 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035004008 TM-ABC transporter signature motif; other site 754035004009 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 754035004010 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035004011 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035004012 TM-ABC transporter signature motif; other site 754035004013 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035004014 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035004015 Walker A/P-loop; other site 754035004016 ATP binding site [chemical binding]; other site 754035004017 Q-loop/lid; other site 754035004018 ABC transporter signature motif; other site 754035004019 Walker B; other site 754035004020 D-loop; other site 754035004021 H-loop/switch region; other site 754035004022 Uncharacterized conserved protein [Function unknown]; Region: COG3743 754035004023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035004024 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035004025 Walker A/P-loop; other site 754035004026 ATP binding site [chemical binding]; other site 754035004027 Q-loop/lid; other site 754035004028 ABC transporter signature motif; other site 754035004029 Walker B; other site 754035004030 D-loop; other site 754035004031 H-loop/switch region; other site 754035004032 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035004033 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 754035004034 dimerization interface [polypeptide binding]; other site 754035004035 ligand binding site [chemical binding]; other site 754035004036 pyruvate carboxylase; Reviewed; Region: PRK12999 754035004037 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035004038 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 754035004039 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754035004040 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 754035004041 active site 754035004042 catalytic residues [active] 754035004043 metal binding site [ion binding]; metal-binding site 754035004044 homodimer binding site [polypeptide binding]; other site 754035004045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754035004046 carboxyltransferase (CT) interaction site; other site 754035004047 biotinylation site [posttranslational modification]; other site 754035004048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 754035004049 methionine sulfoxide reductase B; Provisional; Region: PRK00222 754035004050 SelR domain; Region: SelR; pfam01641 754035004051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 754035004052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035004053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035004054 Coenzyme A binding pocket [chemical binding]; other site 754035004055 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 754035004056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035004057 Walker A motif; other site 754035004058 ATP binding site [chemical binding]; other site 754035004059 Walker B motif; other site 754035004060 arginine finger; other site 754035004061 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 754035004062 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 754035004063 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035004064 putative active site [active] 754035004065 metal binding site [ion binding]; metal-binding site 754035004066 homodimer binding site [polypeptide binding]; other site 754035004067 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 754035004068 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 754035004069 putative hydrophobic ligand binding site [chemical binding]; other site 754035004070 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 754035004071 active site 754035004072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035004073 hydrophobic ligand binding site; other site 754035004074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035004075 dimerization interface [polypeptide binding]; other site 754035004076 putative DNA binding site [nucleotide binding]; other site 754035004077 putative Zn2+ binding site [ion binding]; other site 754035004078 hypothetical protein; Validated; Region: PRK00110 754035004079 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 754035004080 Predicted integral membrane protein [Function unknown]; Region: COG5500 754035004081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035004082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035004083 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 754035004084 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 754035004085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035004086 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 754035004087 Walker A/P-loop; other site 754035004088 ATP binding site [chemical binding]; other site 754035004089 Q-loop/lid; other site 754035004090 ABC transporter signature motif; other site 754035004091 Walker B; other site 754035004092 D-loop; other site 754035004093 H-loop/switch region; other site 754035004094 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 754035004095 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 754035004096 active site 754035004097 Zn binding site [ion binding]; other site 754035004098 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 754035004099 hypothetical protein; Validated; Region: PRK09039 754035004100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754035004101 ligand binding site [chemical binding]; other site 754035004102 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 754035004103 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035004104 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 754035004105 active site 754035004106 dimerization interface [polypeptide binding]; other site 754035004107 elongation factor P; Validated; Region: PRK00529 754035004108 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754035004109 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754035004110 RNA binding site [nucleotide binding]; other site 754035004111 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754035004112 RNA binding site [nucleotide binding]; other site 754035004113 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754035004114 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 754035004115 thiamine phosphate binding site [chemical binding]; other site 754035004116 active site 754035004117 pyrophosphate binding site [ion binding]; other site 754035004118 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754035004119 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 754035004120 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 754035004121 AsnC family; Region: AsnC_trans_reg; pfam01037 754035004122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035004123 S-adenosylmethionine binding site [chemical binding]; other site 754035004124 Predicted permeases [General function prediction only]; Region: COG0730 754035004125 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 754035004126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 754035004127 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 754035004128 active site 754035004129 putative DNA-binding cleft [nucleotide binding]; other site 754035004130 dimer interface [polypeptide binding]; other site 754035004131 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 754035004132 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 754035004133 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 754035004134 putative active site [active] 754035004135 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 754035004136 RuvA N terminal domain; Region: RuvA_N; pfam01330 754035004137 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 754035004138 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 754035004139 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 754035004140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035004141 Walker A motif; other site 754035004142 ATP binding site [chemical binding]; other site 754035004143 Walker B motif; other site 754035004144 arginine finger; other site 754035004145 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 754035004146 phosphodiesterase YaeI; Provisional; Region: PRK11340 754035004147 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 754035004148 putative active site [active] 754035004149 putative metal binding site [ion binding]; other site 754035004150 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 754035004151 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754035004152 active site 754035004153 TolQ protein; Region: tolQ; TIGR02796 754035004154 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 754035004155 TolR protein; Region: tolR; TIGR02801 754035004156 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 754035004157 translocation protein TolB; Provisional; Region: tolB; PRK05137 754035004158 TolB amino-terminal domain; Region: TolB_N; pfam04052 754035004159 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754035004160 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754035004161 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754035004162 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754035004163 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 754035004164 four helix bundle protein; Region: TIGR02436 754035004165 putative outer membrane lipoprotein; Provisional; Region: PRK09967 754035004166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754035004167 ligand binding site [chemical binding]; other site 754035004168 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 754035004169 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 754035004170 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 754035004171 Ligand Binding Site [chemical binding]; other site 754035004172 FtsH Extracellular; Region: FtsH_ext; pfam06480 754035004173 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 754035004174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035004175 Walker A motif; other site 754035004176 ATP binding site [chemical binding]; other site 754035004177 Walker B motif; other site 754035004178 arginine finger; other site 754035004179 Peptidase family M41; Region: Peptidase_M41; pfam01434 754035004180 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 754035004181 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 754035004182 active site 754035004183 substrate binding site [chemical binding]; other site 754035004184 metal binding site [ion binding]; metal-binding site 754035004185 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035004186 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035004187 serC leader; Mesau_01341 754035004188 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 754035004189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035004190 catalytic residue [active] 754035004191 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 754035004192 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 754035004193 ligand binding site [chemical binding]; other site 754035004194 NAD binding site [chemical binding]; other site 754035004195 dimerization interface [polypeptide binding]; other site 754035004196 catalytic site [active] 754035004197 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 754035004198 putative L-serine binding site [chemical binding]; other site 754035004199 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 754035004200 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035004201 TrkA-N domain; Region: TrkA_N; pfam02254 754035004202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035004203 Cytochrome c; Region: Cytochrom_C; pfam00034 754035004204 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 754035004205 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 754035004206 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 754035004207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035004208 EamA-like transporter family; Region: EamA; pfam00892 754035004209 EamA-like transporter family; Region: EamA; pfam00892 754035004210 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 754035004211 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 754035004212 GDP-binding site [chemical binding]; other site 754035004213 ACT binding site; other site 754035004214 IMP binding site; other site 754035004215 CcdB protein; Region: CcdB; cl03380 754035004216 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 754035004217 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754035004218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035004219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035004220 Thiamine pyrophosphokinase; Region: TPK; cd07995 754035004221 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 754035004222 active site 754035004223 dimerization interface [polypeptide binding]; other site 754035004224 thiamine binding site [chemical binding]; other site 754035004225 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 754035004226 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 754035004227 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 754035004228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004229 dimer interface [polypeptide binding]; other site 754035004230 conserved gate region; other site 754035004231 putative PBP binding loops; other site 754035004232 ABC-ATPase subunit interface; other site 754035004233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004234 dimer interface [polypeptide binding]; other site 754035004235 conserved gate region; other site 754035004236 putative PBP binding loops; other site 754035004237 ABC-ATPase subunit interface; other site 754035004238 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 754035004239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035004240 Walker A/P-loop; other site 754035004241 ATP binding site [chemical binding]; other site 754035004242 Q-loop/lid; other site 754035004243 ABC transporter signature motif; other site 754035004244 Walker B; other site 754035004245 D-loop; other site 754035004246 H-loop/switch region; other site 754035004247 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 754035004248 Peptidase family M48; Region: Peptidase_M48; pfam01435 754035004249 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 754035004250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035004251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035004252 DNA binding residues [nucleotide binding] 754035004253 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035004254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035004255 substrate binding pocket [chemical binding]; other site 754035004256 membrane-bound complex binding site; other site 754035004257 hinge residues; other site 754035004258 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004260 dimer interface [polypeptide binding]; other site 754035004261 conserved gate region; other site 754035004262 putative PBP binding loops; other site 754035004263 ABC-ATPase subunit interface; other site 754035004264 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035004265 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035004266 Walker A/P-loop; other site 754035004267 ATP binding site [chemical binding]; other site 754035004268 Q-loop/lid; other site 754035004269 ABC transporter signature motif; other site 754035004270 Walker B; other site 754035004271 D-loop; other site 754035004272 H-loop/switch region; other site 754035004273 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 754035004274 Ferredoxin [Energy production and conversion]; Region: COG1146 754035004275 4Fe-4S binding domain; Region: Fer4; pfam00037 754035004276 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 754035004277 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035004278 RNA binding surface [nucleotide binding]; other site 754035004279 DEAD/DEAH box helicase; Region: DEAD; pfam00270 754035004280 ATP binding site [chemical binding]; other site 754035004281 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 754035004282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035004283 nucleotide binding region [chemical binding]; other site 754035004284 ATP-binding site [chemical binding]; other site 754035004285 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 754035004286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035004287 NAD(P) binding site [chemical binding]; other site 754035004288 active site 754035004289 putative acyltransferase; Provisional; Region: PRK05790 754035004290 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754035004291 dimer interface [polypeptide binding]; other site 754035004292 active site 754035004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 754035004294 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 754035004295 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 754035004296 Helix-turn-helix domain; Region: HTH_17; pfam12728 754035004297 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 754035004298 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 754035004299 dimer interface [polypeptide binding]; other site 754035004300 active site 754035004301 coenzyme A binding site [chemical binding]; other site 754035004302 citrylCoA binding site [chemical binding]; other site 754035004303 oxalacetate/citrate binding site [chemical binding]; other site 754035004304 catalytic triad [active] 754035004305 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 754035004306 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 754035004307 active site 754035004308 nucleophile elbow; other site 754035004309 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035004310 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035004311 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035004312 Protein export membrane protein; Region: SecD_SecF; cl14618 754035004313 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 754035004314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035004315 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 754035004316 putative NAD(P) binding site [chemical binding]; other site 754035004317 putative active site [active] 754035004318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035004319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035004320 LysR substrate binding domain; Region: LysR_substrate; pfam03466 754035004321 dimerization interface [polypeptide binding]; other site 754035004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035004323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 754035004324 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 754035004325 Predicted integral membrane protein [Function unknown]; Region: COG5480 754035004326 pyruvate kinase; Provisional; Region: PRK06247 754035004327 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 754035004328 domain interfaces; other site 754035004329 active site 754035004330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035004331 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754035004332 catalytic site [active] 754035004333 TPR repeat; Region: TPR_11; pfam13414 754035004334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035004335 TPR motif; other site 754035004336 TPR repeat; Region: TPR_11; pfam13414 754035004337 binding surface 754035004338 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 754035004339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 754035004340 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 754035004341 ATP-grasp domain; Region: ATP-grasp; pfam02222 754035004342 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 754035004343 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 754035004344 RNA polymerase sigma factor; Provisional; Region: PRK11924 754035004345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035004346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035004347 DNA binding residues [nucleotide binding] 754035004348 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 754035004349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035004350 catalytic residue [active] 754035004351 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 754035004352 homotrimer interaction site [polypeptide binding]; other site 754035004353 putative active site [active] 754035004354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035004355 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035004356 Walker A/P-loop; other site 754035004357 ATP binding site [chemical binding]; other site 754035004358 Q-loop/lid; other site 754035004359 ABC transporter signature motif; other site 754035004360 Walker B; other site 754035004361 D-loop; other site 754035004362 H-loop/switch region; other site 754035004363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004364 dimer interface [polypeptide binding]; other site 754035004365 conserved gate region; other site 754035004366 putative PBP binding loops; other site 754035004367 ABC-ATPase subunit interface; other site 754035004368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004369 dimer interface [polypeptide binding]; other site 754035004370 conserved gate region; other site 754035004371 putative PBP binding loops; other site 754035004372 ABC-ATPase subunit interface; other site 754035004373 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035004374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035004375 substrate binding pocket [chemical binding]; other site 754035004376 membrane-bound complex binding site; other site 754035004377 hinge residues; other site 754035004378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 754035004379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035004380 putative DNA binding site [nucleotide binding]; other site 754035004381 putative Zn2+ binding site [ion binding]; other site 754035004382 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 754035004383 Uncharacterized small protein [Function unknown]; Region: COG5570 754035004384 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 754035004385 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754035004386 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754035004387 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 754035004388 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035004389 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035004390 catalytic residue [active] 754035004391 Sporulation related domain; Region: SPOR; pfam05036 754035004392 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 754035004393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035004394 dimer interface [polypeptide binding]; other site 754035004395 phosphorylation site [posttranslational modification] 754035004396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035004397 ATP binding site [chemical binding]; other site 754035004398 Mg2+ binding site [ion binding]; other site 754035004399 G-X-G motif; other site 754035004400 Response regulator receiver domain; Region: Response_reg; pfam00072 754035004401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004402 active site 754035004403 phosphorylation site [posttranslational modification] 754035004404 intermolecular recognition site; other site 754035004405 dimerization interface [polypeptide binding]; other site 754035004406 Response regulator receiver domain; Region: Response_reg; pfam00072 754035004407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004408 active site 754035004409 phosphorylation site [posttranslational modification] 754035004410 intermolecular recognition site; other site 754035004411 dimerization interface [polypeptide binding]; other site 754035004412 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754035004413 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754035004414 substrate binding pocket [chemical binding]; other site 754035004415 chain length determination region; other site 754035004416 catalytic residues [active] 754035004417 aspartate-rich region 1; other site 754035004418 substrate-Mg2+ binding site; other site 754035004419 active site lid residues [active] 754035004420 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 754035004421 Transglycosylase; Region: Transgly; pfam00912 754035004422 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 754035004423 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 754035004424 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035004425 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035004426 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035004427 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 754035004428 TAP-like protein; Region: Abhydrolase_4; pfam08386 754035004429 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035004430 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754035004431 C-terminal domain interface [polypeptide binding]; other site 754035004432 GSH binding site (G-site) [chemical binding]; other site 754035004433 dimer interface [polypeptide binding]; other site 754035004434 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035004435 N-terminal domain interface [polypeptide binding]; other site 754035004436 dimer interface [polypeptide binding]; other site 754035004437 substrate binding pocket (H-site) [chemical binding]; other site 754035004438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035004439 dimerization interface [polypeptide binding]; other site 754035004440 putative DNA binding site [nucleotide binding]; other site 754035004441 putative Zn2+ binding site [ion binding]; other site 754035004442 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 754035004443 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 754035004444 putative hydrophobic ligand binding site [chemical binding]; other site 754035004445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035004446 dimerization interface [polypeptide binding]; other site 754035004447 putative DNA binding site [nucleotide binding]; other site 754035004448 putative Zn2+ binding site [ion binding]; other site 754035004449 putative MFS family transporter protein; Provisional; Region: PRK03633 754035004450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035004451 putative substrate translocation pore; other site 754035004452 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 754035004453 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 754035004454 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 754035004455 NAD(P) binding site [chemical binding]; other site 754035004456 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035004457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 754035004458 Predicted transcriptional regulator [Transcription]; Region: COG2378 754035004459 HTH domain; Region: HTH_11; pfam08279 754035004460 WYL domain; Region: WYL; pfam13280 754035004461 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 754035004462 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 754035004463 conserved cys residue [active] 754035004464 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 754035004465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035004466 Zn binding site [ion binding]; other site 754035004467 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 754035004468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035004469 Zn binding site [ion binding]; other site 754035004470 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 754035004471 active site 754035004472 catalytic triad [active] 754035004473 oxyanion hole [active] 754035004474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 754035004475 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 754035004476 active site 754035004477 intersubunit interface [polypeptide binding]; other site 754035004478 catalytic residue [active] 754035004479 Phosphoglycerate kinase; Region: PGK; pfam00162 754035004480 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 754035004481 substrate binding site [chemical binding]; other site 754035004482 hinge regions; other site 754035004483 ADP binding site [chemical binding]; other site 754035004484 catalytic site [active] 754035004485 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 754035004486 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 754035004487 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 754035004488 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754035004489 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 754035004490 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 754035004491 TPP-binding site [chemical binding]; other site 754035004492 dimer interface [polypeptide binding]; other site 754035004493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754035004494 PYR/PP interface [polypeptide binding]; other site 754035004495 dimer interface [polypeptide binding]; other site 754035004496 TPP binding site [chemical binding]; other site 754035004497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754035004498 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 754035004499 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 754035004500 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754035004501 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 754035004502 dimer interface [polypeptide binding]; other site 754035004503 decamer (pentamer of dimers) interface [polypeptide binding]; other site 754035004504 catalytic triad [active] 754035004505 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754035004506 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 754035004507 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754035004508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035004509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035004510 DNA binding residues [nucleotide binding] 754035004511 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754035004512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035004513 RNA binding surface [nucleotide binding]; other site 754035004514 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754035004515 active site 754035004516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035004517 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 754035004518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035004519 PAS domain; Region: PAS_9; pfam13426 754035004520 putative active site [active] 754035004521 heme pocket [chemical binding]; other site 754035004522 PAS fold; Region: PAS_7; pfam12860 754035004523 PAS fold; Region: PAS_7; pfam12860 754035004524 PAS fold; Region: PAS_4; pfam08448 754035004525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035004526 putative active site [active] 754035004527 heme pocket [chemical binding]; other site 754035004528 PAS fold; Region: PAS_7; pfam12860 754035004529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035004530 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 754035004531 putative active site [active] 754035004532 heme pocket [chemical binding]; other site 754035004533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035004534 putative active site [active] 754035004535 heme pocket [chemical binding]; other site 754035004536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035004537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035004538 dimer interface [polypeptide binding]; other site 754035004539 phosphorylation site [posttranslational modification] 754035004540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035004541 ATP binding site [chemical binding]; other site 754035004542 Mg2+ binding site [ion binding]; other site 754035004543 G-X-G motif; other site 754035004544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035004545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004546 active site 754035004547 phosphorylation site [posttranslational modification] 754035004548 intermolecular recognition site; other site 754035004549 dimerization interface [polypeptide binding]; other site 754035004550 Response regulator receiver domain; Region: Response_reg; pfam00072 754035004551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004552 active site 754035004553 phosphorylation site [posttranslational modification] 754035004554 intermolecular recognition site; other site 754035004555 dimerization interface [polypeptide binding]; other site 754035004556 PBP superfamily domain; Region: PBP_like_2; cl17296 754035004557 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 754035004558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004559 dimer interface [polypeptide binding]; other site 754035004560 conserved gate region; other site 754035004561 putative PBP binding loops; other site 754035004562 ABC-ATPase subunit interface; other site 754035004563 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 754035004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004565 dimer interface [polypeptide binding]; other site 754035004566 conserved gate region; other site 754035004567 putative PBP binding loops; other site 754035004568 ABC-ATPase subunit interface; other site 754035004569 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 754035004570 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 754035004571 Walker A/P-loop; other site 754035004572 ATP binding site [chemical binding]; other site 754035004573 Q-loop/lid; other site 754035004574 ABC transporter signature motif; other site 754035004575 Walker B; other site 754035004576 D-loop; other site 754035004577 H-loop/switch region; other site 754035004578 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 754035004579 PhoU domain; Region: PhoU; pfam01895 754035004580 PhoU domain; Region: PhoU; pfam01895 754035004581 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 754035004582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004583 active site 754035004584 phosphorylation site [posttranslational modification] 754035004585 intermolecular recognition site; other site 754035004586 dimerization interface [polypeptide binding]; other site 754035004587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035004588 DNA binding site [nucleotide binding] 754035004589 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035004590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035004591 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 754035004592 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 754035004593 putative ligand binding site [chemical binding]; other site 754035004594 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035004595 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035004596 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035004597 TM-ABC transporter signature motif; other site 754035004598 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035004599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035004600 Walker A/P-loop; other site 754035004601 ATP binding site [chemical binding]; other site 754035004602 Q-loop/lid; other site 754035004603 ABC transporter signature motif; other site 754035004604 Walker B; other site 754035004605 D-loop; other site 754035004606 H-loop/switch region; other site 754035004607 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 754035004608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035004609 HWE histidine kinase; Region: HWE_HK; pfam07536 754035004610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035004611 HWE histidine kinase; Region: HWE_HK; pfam07536 754035004612 two-component response regulator; Provisional; Region: PRK09191 754035004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004614 active site 754035004615 phosphorylation site [posttranslational modification] 754035004616 intermolecular recognition site; other site 754035004617 dimerization interface [polypeptide binding]; other site 754035004618 RNA polymerase sigma factor; Provisional; Region: PRK12547 754035004619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035004620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035004621 DNA binding residues [nucleotide binding] 754035004622 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004624 active site 754035004625 phosphorylation site [posttranslational modification] 754035004626 intermolecular recognition site; other site 754035004627 dimerization interface [polypeptide binding]; other site 754035004628 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035004629 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035004630 ligand binding site [chemical binding]; other site 754035004631 flexible hinge region; other site 754035004632 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035004633 putative switch regulator; other site 754035004634 non-specific DNA interactions [nucleotide binding]; other site 754035004635 DNA binding site [nucleotide binding] 754035004636 sequence specific DNA binding site [nucleotide binding]; other site 754035004637 putative cAMP binding site [chemical binding]; other site 754035004638 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 754035004639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754035004640 GAF domain; Region: GAF; pfam01590 754035004641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035004642 HWE histidine kinase; Region: HWE_HK; pfam07536 754035004643 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 754035004644 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 754035004645 PRC-barrel domain; Region: PRC; pfam05239 754035004646 PRC-barrel domain; Region: PRC; pfam05239 754035004647 Sulfatase; Region: Sulfatase; cl17466 754035004648 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 754035004649 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 754035004650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035004651 Zn binding site [ion binding]; other site 754035004652 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 754035004653 Zn binding site [ion binding]; other site 754035004654 Predicted esterase [General function prediction only]; Region: COG0400 754035004655 Predicted acetyltransferase [General function prediction only]; Region: COG2388 754035004656 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 754035004657 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 754035004658 active site 754035004659 dimer interface [polypeptide binding]; other site 754035004660 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035004661 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035004662 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 754035004663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035004664 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 754035004665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035004666 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 754035004667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035004668 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 754035004669 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035004670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035004671 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 754035004672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035004673 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035004674 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035004675 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 754035004676 Walker A/P-loop; other site 754035004677 ATP binding site [chemical binding]; other site 754035004678 Q-loop/lid; other site 754035004679 ABC transporter signature motif; other site 754035004680 Walker B; other site 754035004681 D-loop; other site 754035004682 H-loop/switch region; other site 754035004683 TOBE domain; Region: TOBE_2; pfam08402 754035004684 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035004685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004686 dimer interface [polypeptide binding]; other site 754035004687 conserved gate region; other site 754035004688 putative PBP binding loops; other site 754035004689 ABC-ATPase subunit interface; other site 754035004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004691 dimer interface [polypeptide binding]; other site 754035004692 conserved gate region; other site 754035004693 putative PBP binding loops; other site 754035004694 ABC-ATPase subunit interface; other site 754035004695 hypothetical protein; Provisional; Region: PRK07036 754035004696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035004697 inhibitor-cofactor binding pocket; inhibition site 754035004698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035004699 catalytic residue [active] 754035004700 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035004701 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035004702 [2Fe-2S] cluster binding site [ion binding]; other site 754035004703 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 754035004704 alpha subunit interface [polypeptide binding]; other site 754035004705 active site 754035004706 substrate binding site [chemical binding]; other site 754035004707 Fe binding site [ion binding]; other site 754035004708 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754035004709 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754035004710 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 754035004711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035004712 putative active site [active] 754035004713 heme pocket [chemical binding]; other site 754035004714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035004715 dimer interface [polypeptide binding]; other site 754035004716 phosphorylation site [posttranslational modification] 754035004717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035004718 ATP binding site [chemical binding]; other site 754035004719 Mg2+ binding site [ion binding]; other site 754035004720 G-X-G motif; other site 754035004721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004722 active site 754035004723 phosphorylation site [posttranslational modification] 754035004724 intermolecular recognition site; other site 754035004725 dimerization interface [polypeptide binding]; other site 754035004726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035004727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035004728 active site 754035004729 phosphorylation site [posttranslational modification] 754035004730 intermolecular recognition site; other site 754035004731 dimerization interface [polypeptide binding]; other site 754035004732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035004733 DNA binding site [nucleotide binding] 754035004734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035004735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035004736 DNA binding site [nucleotide binding] 754035004737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035004738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035004739 multidrug efflux protein; Reviewed; Region: PRK09579 754035004740 Protein export membrane protein; Region: SecD_SecF; cl14618 754035004741 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035004742 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035004743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035004744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035004745 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035004746 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035004747 Walker A/P-loop; other site 754035004748 ATP binding site [chemical binding]; other site 754035004749 Q-loop/lid; other site 754035004750 ABC transporter signature motif; other site 754035004751 Walker B; other site 754035004752 D-loop; other site 754035004753 H-loop/switch region; other site 754035004754 TOBE domain; Region: TOBE; pfam03459 754035004755 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035004756 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 754035004757 substrate binding site [chemical binding]; other site 754035004758 ATP binding site [chemical binding]; other site 754035004759 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 754035004760 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 754035004761 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 754035004762 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035004763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004764 dimer interface [polypeptide binding]; other site 754035004765 conserved gate region; other site 754035004766 putative PBP binding loops; other site 754035004767 ABC-ATPase subunit interface; other site 754035004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004769 dimer interface [polypeptide binding]; other site 754035004770 conserved gate region; other site 754035004771 putative PBP binding loops; other site 754035004772 ABC-ATPase subunit interface; other site 754035004773 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035004774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035004775 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035004776 non-specific DNA interactions [nucleotide binding]; other site 754035004777 DNA binding site [nucleotide binding] 754035004778 sequence specific DNA binding site [nucleotide binding]; other site 754035004779 putative cAMP binding site [chemical binding]; other site 754035004780 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035004781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035004782 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754035004783 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754035004784 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 754035004785 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 754035004786 Cl binding site [ion binding]; other site 754035004787 oligomer interface [polypeptide binding]; other site 754035004788 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 754035004789 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 754035004790 active site 754035004791 nucleophile elbow; other site 754035004792 Patatin phospholipase; Region: DUF3734; pfam12536 754035004793 acetoacetate decarboxylase; Provisional; Region: PRK02265 754035004794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035004795 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 754035004796 NAD(P) binding site [chemical binding]; other site 754035004797 active site 754035004798 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 754035004799 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035004800 active site 754035004801 metal binding site [ion binding]; metal-binding site 754035004802 hexamer interface [polypeptide binding]; other site 754035004803 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 754035004804 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 754035004805 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 754035004806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035004807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035004808 acyl-activating enzyme (AAE) consensus motif; other site 754035004809 acyl-activating enzyme (AAE) consensus motif; other site 754035004810 AMP binding site [chemical binding]; other site 754035004811 active site 754035004812 CoA binding site [chemical binding]; other site 754035004813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 754035004814 Thioesterase domain; Region: Thioesterase; pfam00975 754035004815 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 754035004816 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754035004817 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 754035004818 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 754035004819 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 754035004820 tetramer interface [polypeptide binding]; other site 754035004821 TPP-binding site [chemical binding]; other site 754035004822 heterodimer interface [polypeptide binding]; other site 754035004823 phosphorylation loop region [posttranslational modification] 754035004824 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 754035004825 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 754035004826 alpha subunit interface [polypeptide binding]; other site 754035004827 TPP binding site [chemical binding]; other site 754035004828 heterodimer interface [polypeptide binding]; other site 754035004829 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754035004830 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 754035004831 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035004832 E3 interaction surface; other site 754035004833 lipoyl attachment site [posttranslational modification]; other site 754035004834 e3 binding domain; Region: E3_binding; pfam02817 754035004835 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754035004836 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035004837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 754035004838 DNA binding residues [nucleotide binding] 754035004839 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035004840 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035004841 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035004842 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754035004843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004844 dimer interface [polypeptide binding]; other site 754035004845 conserved gate region; other site 754035004846 putative PBP binding loops; other site 754035004847 ABC-ATPase subunit interface; other site 754035004848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035004849 dimer interface [polypeptide binding]; other site 754035004850 conserved gate region; other site 754035004851 putative PBP binding loops; other site 754035004852 ABC-ATPase subunit interface; other site 754035004853 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035004854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035004855 Walker A/P-loop; other site 754035004856 ATP binding site [chemical binding]; other site 754035004857 Q-loop/lid; other site 754035004858 ABC transporter signature motif; other site 754035004859 Walker B; other site 754035004860 D-loop; other site 754035004861 H-loop/switch region; other site 754035004862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035004863 Survival protein SurE; Region: SurE; cl00448 754035004864 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 754035004865 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 754035004866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035004867 active site 754035004868 motif I; other site 754035004869 motif II; other site 754035004870 Glucitol operon activator [Transcription]; Region: GutM; COG4578 754035004871 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 754035004872 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 754035004873 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 754035004874 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 754035004875 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 754035004876 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754035004877 dimerization domain swap beta strand [polypeptide binding]; other site 754035004878 regulatory protein interface [polypeptide binding]; other site 754035004879 active site 754035004880 regulatory phosphorylation site [posttranslational modification]; other site 754035004881 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 754035004882 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754035004883 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754035004884 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754035004885 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035004886 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035004887 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 754035004888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035004889 active site 754035004890 motif I; other site 754035004891 motif II; other site 754035004892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035004893 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754035004894 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035004895 nucleotide binding site [chemical binding]; other site 754035004896 Uncharacterized conserved protein [Function unknown]; Region: COG3347 754035004897 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 754035004898 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035004899 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754035004900 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035004901 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754035004902 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 754035004903 N- and C-terminal domain interface [polypeptide binding]; other site 754035004904 putative active site [active] 754035004905 putative MgATP binding site [chemical binding]; other site 754035004906 putative catalytic site [active] 754035004907 metal binding site [ion binding]; metal-binding site 754035004908 putative carbohydrate binding site [chemical binding]; other site 754035004909 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035004910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035004911 Walker A/P-loop; other site 754035004912 ATP binding site [chemical binding]; other site 754035004913 Q-loop/lid; other site 754035004914 ABC transporter signature motif; other site 754035004915 Walker B; other site 754035004916 D-loop; other site 754035004917 H-loop/switch region; other site 754035004918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035004919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035004920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035004921 TM-ABC transporter signature motif; other site 754035004922 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 754035004923 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035004924 putative ligand binding site [chemical binding]; other site 754035004925 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035004926 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035004927 AP (apurinic/apyrimidinic) site pocket; other site 754035004928 Metal-binding active site; metal-binding site 754035004929 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 754035004930 Predicted membrane protein [Function unknown]; Region: COG4244 754035004931 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035004932 NmrA-like family; Region: NmrA; pfam05368 754035004933 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 754035004934 NADP binding site [chemical binding]; other site 754035004935 active site 754035004936 regulatory binding site [polypeptide binding]; other site 754035004937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035004938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035004939 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035004940 putative effector binding pocket; other site 754035004941 dimerization interface [polypeptide binding]; other site 754035004942 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754035004943 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 754035004944 metal binding site [ion binding]; metal-binding site 754035004945 putative dimer interface [polypeptide binding]; other site 754035004946 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754035004947 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 754035004948 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 754035004949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035004950 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 754035004951 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 754035004952 CPxP motif; other site 754035004953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 754035004954 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 754035004955 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 754035004956 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 754035004957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754035004958 active site 754035004959 DNA binding site [nucleotide binding] 754035004960 Int/Topo IB signature motif; other site 754035004961 shikimate kinase; Provisional; Region: PRK13946 754035004962 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754035004963 ADP binding site [chemical binding]; other site 754035004964 magnesium binding site [ion binding]; other site 754035004965 putative shikimate binding site; other site 754035004966 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 754035004967 active site 754035004968 dimer interface [polypeptide binding]; other site 754035004969 metal binding site [ion binding]; metal-binding site 754035004970 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 754035004971 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754035004972 Transporter associated domain; Region: CorC_HlyC; smart01091 754035004973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 754035004974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 754035004975 SpoVR family protein; Provisional; Region: PRK11767 754035004976 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 754035004977 Uncharacterized conserved protein [Function unknown]; Region: COG2718 754035004978 PrkA family serine protein kinase; Provisional; Region: PRK15455 754035004979 AAA ATPase domain; Region: AAA_16; pfam13191 754035004980 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 754035004981 hypothetical protein; Validated; Region: PRK07586 754035004982 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035004983 PYR/PP interface [polypeptide binding]; other site 754035004984 dimer interface [polypeptide binding]; other site 754035004985 TPP binding site [chemical binding]; other site 754035004986 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 754035004987 TPP-binding site [chemical binding]; other site 754035004988 dimer interface [polypeptide binding]; other site 754035004989 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 754035004990 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 754035004991 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035004992 HSP70 interaction site [polypeptide binding]; other site 754035004993 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 754035004994 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 754035004995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754035004996 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 754035004997 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 754035004998 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 754035004999 metal ion-dependent adhesion site (MIDAS); other site 754035005000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 754035005001 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 754035005002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035005003 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 754035005004 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 754035005005 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 754035005006 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035005007 EamA-like transporter family; Region: EamA; pfam00892 754035005008 Predicted membrane protein [Function unknown]; Region: COG3714 754035005009 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 754035005010 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 754035005011 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035005012 Methyltransferase domain; Region: Methyltransf_11; pfam08241 754035005013 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 754035005014 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 754035005015 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 754035005016 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035005017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035005018 active site 754035005019 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035005020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035005021 S-adenosylmethionine binding site [chemical binding]; other site 754035005022 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 754035005023 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 754035005024 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 754035005025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035005026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035005027 homodimer interface [polypeptide binding]; other site 754035005028 catalytic residue [active] 754035005029 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 754035005030 prephenate dehydrogenase; Validated; Region: PRK08507 754035005031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035005032 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 754035005033 substrate binding site [chemical binding]; other site 754035005034 ATP binding site [chemical binding]; other site 754035005035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 754035005036 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 754035005037 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 754035005038 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754035005039 putative active site pocket [active] 754035005040 dimerization interface [polypeptide binding]; other site 754035005041 putative catalytic residue [active] 754035005042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035005043 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035005044 active site 754035005045 catalytic tetrad [active] 754035005046 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754035005047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754035005048 putative acyl-acceptor binding pocket; other site 754035005049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035005050 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 754035005051 putative effector binding pocket; other site 754035005052 putative dimerization interface [polypeptide binding]; other site 754035005053 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 754035005054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 754035005055 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035005056 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 754035005057 Uncharacterized conserved protein [Function unknown]; Region: COG1434 754035005058 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754035005059 putative active site [active] 754035005060 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 754035005061 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 754035005062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754035005063 Walker A/P-loop; other site 754035005064 ATP binding site [chemical binding]; other site 754035005065 Q-loop/lid; other site 754035005066 ABC transporter signature motif; other site 754035005067 Walker B; other site 754035005068 D-loop; other site 754035005069 H-loop/switch region; other site 754035005070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035005071 active site 754035005072 Response regulator receiver domain; Region: Response_reg; pfam00072 754035005073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035005074 active site 754035005075 phosphorylation site [posttranslational modification] 754035005076 intermolecular recognition site; other site 754035005077 dimerization interface [polypeptide binding]; other site 754035005078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035005079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035005080 LysR substrate binding domain; Region: LysR_substrate; pfam03466 754035005081 dimerization interface [polypeptide binding]; other site 754035005082 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 754035005083 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 754035005084 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754035005085 tetramer interface [polypeptide binding]; other site 754035005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035005087 catalytic residue [active] 754035005088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035005089 dimerization interface [polypeptide binding]; other site 754035005090 putative DNA binding site [nucleotide binding]; other site 754035005091 putative Zn2+ binding site [ion binding]; other site 754035005092 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 754035005093 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 754035005094 active site 754035005095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035005096 substrate binding site [chemical binding]; other site 754035005097 catalytic residues [active] 754035005098 dimer interface [polypeptide binding]; other site 754035005099 argininosuccinate lyase; Provisional; Region: PRK00855 754035005100 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 754035005101 active sites [active] 754035005102 tetramer interface [polypeptide binding]; other site 754035005103 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 754035005104 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035005105 catalytic residues [active] 754035005106 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 754035005107 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 754035005108 PAS domain S-box; Region: sensory_box; TIGR00229 754035005109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035005110 putative active site [active] 754035005111 heme pocket [chemical binding]; other site 754035005112 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035005113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035005114 metal binding site [ion binding]; metal-binding site 754035005115 active site 754035005116 I-site; other site 754035005117 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035005118 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 754035005119 putative catalytic site [active] 754035005120 putative metal binding site [ion binding]; other site 754035005121 putative catalytic site [active] 754035005122 putative phosphate binding site [ion binding]; other site 754035005123 putative phosphate binding site [ion binding]; other site 754035005124 putative metal binding site [ion binding]; other site 754035005125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035005126 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035005127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035005128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005129 putative PBP binding loops; other site 754035005130 ABC-ATPase subunit interface; other site 754035005131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035005132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005133 dimer interface [polypeptide binding]; other site 754035005134 conserved gate region; other site 754035005135 putative PBP binding loops; other site 754035005136 ABC-ATPase subunit interface; other site 754035005137 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035005138 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035005139 Walker A/P-loop; other site 754035005140 ATP binding site [chemical binding]; other site 754035005141 Q-loop/lid; other site 754035005142 ABC transporter signature motif; other site 754035005143 Walker B; other site 754035005144 D-loop; other site 754035005145 H-loop/switch region; other site 754035005146 TOBE domain; Region: TOBE_2; pfam08402 754035005147 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 754035005148 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035005149 active site 754035005150 metal binding site [ion binding]; metal-binding site 754035005151 hexamer interface [polypeptide binding]; other site 754035005152 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035005153 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754035005154 Walker A/P-loop; other site 754035005155 ATP binding site [chemical binding]; other site 754035005156 Q-loop/lid; other site 754035005157 ABC transporter signature motif; other site 754035005158 Walker B; other site 754035005159 D-loop; other site 754035005160 H-loop/switch region; other site 754035005161 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754035005162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005163 dimer interface [polypeptide binding]; other site 754035005164 conserved gate region; other site 754035005165 putative PBP binding loops; other site 754035005166 ABC-ATPase subunit interface; other site 754035005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005168 dimer interface [polypeptide binding]; other site 754035005169 conserved gate region; other site 754035005170 putative PBP binding loops; other site 754035005171 ABC-ATPase subunit interface; other site 754035005172 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035005173 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754035005174 RNA polymerase sigma factor; Provisional; Region: PRK12512 754035005175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035005176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035005177 DNA binding residues [nucleotide binding] 754035005178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 754035005179 PAS domain S-box; Region: sensory_box; TIGR00229 754035005180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035005181 putative active site [active] 754035005182 heme pocket [chemical binding]; other site 754035005183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035005184 PAS fold; Region: PAS_3; pfam08447 754035005185 putative active site [active] 754035005186 heme pocket [chemical binding]; other site 754035005187 PAS fold; Region: PAS; pfam00989 754035005188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035005189 putative active site [active] 754035005190 heme pocket [chemical binding]; other site 754035005191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035005192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035005193 metal binding site [ion binding]; metal-binding site 754035005194 active site 754035005195 I-site; other site 754035005196 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 754035005197 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035005198 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035005199 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 754035005200 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 754035005201 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754035005202 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 754035005203 Ligand binding site [chemical binding]; other site 754035005204 Electron transfer flavoprotein domain; Region: ETF; pfam01012 754035005205 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 754035005206 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 754035005207 short chain dehydrogenase; Provisional; Region: PRK05993 754035005208 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 754035005209 NADP binding site [chemical binding]; other site 754035005210 active site 754035005211 steroid binding site; other site 754035005212 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 754035005213 EamA-like transporter family; Region: EamA; pfam00892 754035005214 EamA-like transporter family; Region: EamA; pfam00892 754035005215 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 754035005216 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 754035005217 active site 754035005218 HIGH motif; other site 754035005219 nucleotide binding site [chemical binding]; other site 754035005220 active site 754035005221 KMSKS motif; other site 754035005222 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754035005223 endonuclease III; Region: ENDO3c; smart00478 754035005224 minor groove reading motif; other site 754035005225 helix-hairpin-helix signature motif; other site 754035005226 substrate binding pocket [chemical binding]; other site 754035005227 active site 754035005228 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 754035005229 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 754035005230 active site 754035005231 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 754035005232 Predicted membrane protein [Function unknown]; Region: COG1238 754035005233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035005234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035005235 putative DNA binding site [nucleotide binding]; other site 754035005236 putative Zn2+ binding site [ion binding]; other site 754035005237 hypothetical protein; Provisional; Region: PRK06184 754035005238 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035005239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035005240 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754035005241 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 754035005242 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 754035005243 Predicted ATPase [General function prediction only]; Region: COG3899 754035005244 AAA ATPase domain; Region: AAA_16; pfam13191 754035005245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035005246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035005247 DNA binding residues [nucleotide binding] 754035005248 dimerization interface [polypeptide binding]; other site 754035005249 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 754035005250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754035005251 ATP binding site [chemical binding]; other site 754035005252 putative Mg++ binding site [ion binding]; other site 754035005253 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 754035005254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 754035005255 nucleotide binding region [chemical binding]; other site 754035005256 ATP-binding site [chemical binding]; other site 754035005257 SEC-C motif; Region: SEC-C; pfam02810 754035005258 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 754035005259 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 754035005260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035005261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035005262 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 754035005263 heterotetramer interface [polypeptide binding]; other site 754035005264 active site pocket [active] 754035005265 cleavage site 754035005266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035005267 Coenzyme A binding pocket [chemical binding]; other site 754035005268 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 754035005269 active site 754035005270 8-oxo-dGMP binding site [chemical binding]; other site 754035005271 nudix motif; other site 754035005272 metal binding site [ion binding]; metal-binding site 754035005273 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 754035005274 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 754035005275 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 754035005276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035005277 active site 754035005278 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 754035005279 GSH binding site [chemical binding]; other site 754035005280 catalytic residues [active] 754035005281 Predicted amidohydrolase [General function prediction only]; Region: COG0388 754035005282 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 754035005283 putative active site [active] 754035005284 catalytic triad [active] 754035005285 dimer interface [polypeptide binding]; other site 754035005286 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 754035005287 MarR family; Region: MarR_2; cl17246 754035005288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035005289 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035005290 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 754035005291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035005292 CHASE3 domain; Region: CHASE3; pfam05227 754035005293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035005294 dimer interface [polypeptide binding]; other site 754035005295 phosphorylation site [posttranslational modification] 754035005296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035005297 ATP binding site [chemical binding]; other site 754035005298 Mg2+ binding site [ion binding]; other site 754035005299 G-X-G motif; other site 754035005300 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035005301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035005302 active site 754035005303 phosphorylation site [posttranslational modification] 754035005304 intermolecular recognition site; other site 754035005305 dimerization interface [polypeptide binding]; other site 754035005306 aspartate kinase; Reviewed; Region: PRK06635 754035005307 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 754035005308 putative nucleotide binding site [chemical binding]; other site 754035005309 putative catalytic residues [active] 754035005310 putative Mg ion binding site [ion binding]; other site 754035005311 putative aspartate binding site [chemical binding]; other site 754035005312 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 754035005313 putative allosteric regulatory site; other site 754035005314 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 754035005315 putative allosteric regulatory residue; other site 754035005316 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 754035005317 GAF domain; Region: GAF; pfam01590 754035005318 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754035005319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754035005320 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754035005321 peptide chain release factor 1; Validated; Region: prfA; PRK00591 754035005322 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754035005323 RF-1 domain; Region: RF-1; pfam00472 754035005324 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 754035005325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035005326 S-adenosylmethionine binding site [chemical binding]; other site 754035005327 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 754035005328 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 754035005329 Clp amino terminal domain; Region: Clp_N; pfam02861 754035005330 Clp amino terminal domain; Region: Clp_N; pfam02861 754035005331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035005332 Walker A motif; other site 754035005333 ATP binding site [chemical binding]; other site 754035005334 Walker B motif; other site 754035005335 arginine finger; other site 754035005336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035005337 Walker A motif; other site 754035005338 ATP binding site [chemical binding]; other site 754035005339 Walker B motif; other site 754035005340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754035005341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 754035005342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035005343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035005344 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035005345 Predicted integral membrane protein [Function unknown]; Region: COG3548 754035005346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035005347 putative substrate translocation pore; other site 754035005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035005349 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754035005350 Peptidase family M23; Region: Peptidase_M23; pfam01551 754035005351 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 754035005352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035005353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035005354 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035005355 putative effector binding pocket; other site 754035005356 dimerization interface [polypeptide binding]; other site 754035005357 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 754035005358 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 754035005359 catalytic residues [active] 754035005360 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 754035005361 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754035005362 NAD binding site [chemical binding]; other site 754035005363 substrate binding site [chemical binding]; other site 754035005364 putative active site [active] 754035005365 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035005366 N-acetylmannosamine kinase; Provisional; Region: PRK05082 754035005367 nucleotide binding site [chemical binding]; other site 754035005368 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 754035005369 AAA domain; Region: AAA_33; pfam13671 754035005370 Class I aldolases; Region: Aldolase_Class_I; cl17187 754035005371 catalytic residue [active] 754035005372 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035005373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035005374 DNA binding residues [nucleotide binding] 754035005375 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035005376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035005377 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 754035005378 putative ligand binding site [chemical binding]; other site 754035005379 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035005380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035005381 TM-ABC transporter signature motif; other site 754035005382 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035005383 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035005384 Walker A/P-loop; other site 754035005385 ATP binding site [chemical binding]; other site 754035005386 Q-loop/lid; other site 754035005387 ABC transporter signature motif; other site 754035005388 Walker B; other site 754035005389 D-loop; other site 754035005390 H-loop/switch region; other site 754035005391 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035005392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035005393 Walker A/P-loop; other site 754035005394 ATP binding site [chemical binding]; other site 754035005395 Q-loop/lid; other site 754035005396 ABC transporter signature motif; other site 754035005397 Walker B; other site 754035005398 D-loop; other site 754035005399 H-loop/switch region; other site 754035005400 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754035005401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035005402 Walker A/P-loop; other site 754035005403 ATP binding site [chemical binding]; other site 754035005404 Q-loop/lid; other site 754035005405 ABC transporter signature motif; other site 754035005406 Walker B; other site 754035005407 D-loop; other site 754035005408 H-loop/switch region; other site 754035005409 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035005410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035005411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005412 dimer interface [polypeptide binding]; other site 754035005413 conserved gate region; other site 754035005414 putative PBP binding loops; other site 754035005415 ABC-ATPase subunit interface; other site 754035005416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035005417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005418 dimer interface [polypeptide binding]; other site 754035005419 conserved gate region; other site 754035005420 putative PBP binding loops; other site 754035005421 ABC-ATPase subunit interface; other site 754035005422 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035005423 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 754035005424 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035005425 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035005426 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035005427 active site 754035005428 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 754035005429 Cupin domain; Region: Cupin_2; pfam07883 754035005430 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 754035005431 Uncharacterized conserved protein [Function unknown]; Region: COG5441 754035005432 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 754035005433 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035005434 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035005435 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 754035005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005437 conserved gate region; other site 754035005438 dimer interface [polypeptide binding]; other site 754035005439 putative PBP binding loops; other site 754035005440 ABC-ATPase subunit interface; other site 754035005441 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035005442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005443 dimer interface [polypeptide binding]; other site 754035005444 conserved gate region; other site 754035005445 putative PBP binding loops; other site 754035005446 ABC-ATPase subunit interface; other site 754035005447 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035005448 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035005449 Walker A/P-loop; other site 754035005450 ATP binding site [chemical binding]; other site 754035005451 Q-loop/lid; other site 754035005452 ABC transporter signature motif; other site 754035005453 Walker B; other site 754035005454 D-loop; other site 754035005455 H-loop/switch region; other site 754035005456 TOBE domain; Region: TOBE_2; pfam08402 754035005457 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035005458 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035005459 Walker A/P-loop; other site 754035005460 ATP binding site [chemical binding]; other site 754035005461 Q-loop/lid; other site 754035005462 ABC transporter signature motif; other site 754035005463 Walker B; other site 754035005464 D-loop; other site 754035005465 H-loop/switch region; other site 754035005466 TOBE domain; Region: TOBE_2; pfam08402 754035005467 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035005468 amidase; Provisional; Region: PRK07056 754035005469 amidase; Validated; Region: PRK05962 754035005470 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035005471 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 754035005472 ligand binding site [chemical binding]; other site 754035005473 NAD binding site [chemical binding]; other site 754035005474 dimerization interface [polypeptide binding]; other site 754035005475 catalytic site [active] 754035005476 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035005477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035005478 DNA-binding site [nucleotide binding]; DNA binding site 754035005479 FCD domain; Region: FCD; pfam07729 754035005480 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035005481 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035005482 active site pocket [active] 754035005483 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035005484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035005485 DNA interaction; other site 754035005486 Metal-binding active site; metal-binding site 754035005487 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035005488 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035005489 Metal-binding active site; metal-binding site 754035005490 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 754035005491 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035005492 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035005493 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035005494 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035005495 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035005496 DNA interaction; other site 754035005497 Metal-binding active site; metal-binding site 754035005498 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 754035005499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005500 dimer interface [polypeptide binding]; other site 754035005501 conserved gate region; other site 754035005502 ABC-ATPase subunit interface; other site 754035005503 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 754035005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005505 dimer interface [polypeptide binding]; other site 754035005506 conserved gate region; other site 754035005507 ABC-ATPase subunit interface; other site 754035005508 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 754035005509 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 754035005510 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 754035005511 Walker A/P-loop; other site 754035005512 ATP binding site [chemical binding]; other site 754035005513 Q-loop/lid; other site 754035005514 ABC transporter signature motif; other site 754035005515 Walker B; other site 754035005516 D-loop; other site 754035005517 H-loop/switch region; other site 754035005518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 754035005519 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 754035005520 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 754035005521 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 754035005522 trimer interface [polypeptide binding]; other site 754035005523 active site 754035005524 substrate binding site [chemical binding]; other site 754035005525 CoA binding site [chemical binding]; other site 754035005526 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 754035005527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035005528 Walker A/P-loop; other site 754035005529 ATP binding site [chemical binding]; other site 754035005530 Q-loop/lid; other site 754035005531 ABC transporter signature motif; other site 754035005532 Walker B; other site 754035005533 D-loop; other site 754035005534 H-loop/switch region; other site 754035005535 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 754035005536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035005537 Walker A/P-loop; other site 754035005538 ATP binding site [chemical binding]; other site 754035005539 Q-loop/lid; other site 754035005540 ABC transporter signature motif; other site 754035005541 Walker B; other site 754035005542 D-loop; other site 754035005543 H-loop/switch region; other site 754035005544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035005545 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 754035005546 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 754035005547 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 754035005548 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 754035005549 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 754035005550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035005551 DNA-binding site [nucleotide binding]; DNA binding site 754035005552 UTRA domain; Region: UTRA; pfam07702 754035005553 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754035005554 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 754035005555 putative NAD(P) binding site [chemical binding]; other site 754035005556 catalytic Zn binding site [ion binding]; other site 754035005557 structural Zn binding site [ion binding]; other site 754035005558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035005559 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035005560 TM-ABC transporter signature motif; other site 754035005561 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035005562 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035005563 Walker A/P-loop; other site 754035005564 ATP binding site [chemical binding]; other site 754035005565 Q-loop/lid; other site 754035005566 ABC transporter signature motif; other site 754035005567 Walker B; other site 754035005568 D-loop; other site 754035005569 H-loop/switch region; other site 754035005570 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035005571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035005572 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 754035005573 putative ligand binding site [chemical binding]; other site 754035005574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035005575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035005576 active site 754035005577 catalytic tetrad [active] 754035005578 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 754035005579 galactarate dehydratase; Region: galactar-dH20; TIGR03248 754035005580 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 754035005581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035005582 DNA-binding site [nucleotide binding]; DNA binding site 754035005583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035005584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 754035005585 DNA-binding site [nucleotide binding]; DNA binding site 754035005586 FCD domain; Region: FCD; pfam07729 754035005587 Protein of unknown function (DUF461); Region: DUF461; pfam04314 754035005588 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 754035005589 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 754035005590 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 754035005591 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 754035005592 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035005593 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 754035005594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035005595 LysR family transcriptional regulator; Provisional; Region: PRK14997 754035005596 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035005597 putative effector binding pocket; other site 754035005598 dimerization interface [polypeptide binding]; other site 754035005599 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 754035005600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035005601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035005602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035005603 DNA binding site [nucleotide binding] 754035005604 domain linker motif; other site 754035005605 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 754035005606 ligand binding site [chemical binding]; other site 754035005607 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035005608 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035005609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005610 dimer interface [polypeptide binding]; other site 754035005611 conserved gate region; other site 754035005612 putative PBP binding loops; other site 754035005613 ABC-ATPase subunit interface; other site 754035005614 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035005616 dimer interface [polypeptide binding]; other site 754035005617 conserved gate region; other site 754035005618 putative PBP binding loops; other site 754035005619 ABC-ATPase subunit interface; other site 754035005620 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035005621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035005622 Walker A/P-loop; other site 754035005623 ATP binding site [chemical binding]; other site 754035005624 Q-loop/lid; other site 754035005625 ABC transporter signature motif; other site 754035005626 Walker B; other site 754035005627 D-loop; other site 754035005628 H-loop/switch region; other site 754035005629 TOBE domain; Region: TOBE_2; pfam08402 754035005630 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035005631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035005632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035005633 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035005634 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035005635 active site 754035005636 catalytic tetrad [active] 754035005637 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754035005638 metal binding site 2 [ion binding]; metal-binding site 754035005639 putative DNA binding helix; other site 754035005640 metal binding site 1 [ion binding]; metal-binding site 754035005641 dimer interface [polypeptide binding]; other site 754035005642 structural Zn2+ binding site [ion binding]; other site 754035005643 DNA polymerase I; Region: pola; TIGR00593 754035005644 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 754035005645 active site 754035005646 metal binding site 1 [ion binding]; metal-binding site 754035005647 putative 5' ssDNA interaction site; other site 754035005648 metal binding site 3; metal-binding site 754035005649 metal binding site 2 [ion binding]; metal-binding site 754035005650 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 754035005651 putative DNA binding site [nucleotide binding]; other site 754035005652 putative metal binding site [ion binding]; other site 754035005653 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 754035005654 active site 754035005655 catalytic site [active] 754035005656 substrate binding site [chemical binding]; other site 754035005657 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 754035005658 active site 754035005659 DNA binding site [nucleotide binding] 754035005660 catalytic site [active] 754035005661 hypothetical protein; Validated; Region: PRK09104 754035005662 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 754035005663 metal binding site [ion binding]; metal-binding site 754035005664 putative dimer interface [polypeptide binding]; other site 754035005665 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 754035005666 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 754035005667 catalytic site [active] 754035005668 putative active site [active] 754035005669 putative substrate binding site [chemical binding]; other site 754035005670 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 754035005671 Transglycosylase; Region: Transgly; pfam00912 754035005672 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754035005673 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 754035005674 classical (c) SDRs; Region: SDR_c; cd05233 754035005675 NAD(P) binding site [chemical binding]; other site 754035005676 active site 754035005677 putative cation:proton antiport protein; Provisional; Region: PRK10669 754035005678 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 754035005679 TrkA-N domain; Region: TrkA_N; pfam02254 754035005680 Protein required for attachment to host cells; Region: Host_attach; pfam10116 754035005681 siroheme synthase; Provisional; Region: cysG; PRK10637 754035005682 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 754035005683 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 754035005684 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 754035005685 active site 754035005686 SAM binding site [chemical binding]; other site 754035005687 homodimer interface [polypeptide binding]; other site 754035005688 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 754035005689 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 754035005690 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754035005691 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754035005692 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 754035005693 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754035005694 Active Sites [active] 754035005695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 754035005696 intracellular protease, PfpI family; Region: PfpI; TIGR01382 754035005697 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 754035005698 conserved cys residue [active] 754035005699 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 754035005700 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 754035005701 putative di-iron ligands [ion binding]; other site 754035005702 heat shock protein GrpE; Provisional; Region: PRK14141 754035005703 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 754035005704 dimer interface [polypeptide binding]; other site 754035005705 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 754035005706 Predicted membrane protein [Function unknown]; Region: COG2860 754035005707 UPF0126 domain; Region: UPF0126; pfam03458 754035005708 UPF0126 domain; Region: UPF0126; pfam03458 754035005709 Putative hemolysin [General function prediction only]; Region: COG3176 754035005710 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 754035005711 PAS domain; Region: PAS; smart00091 754035005712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035005713 dimer interface [polypeptide binding]; other site 754035005714 phosphorylation site [posttranslational modification] 754035005715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035005716 ATP binding site [chemical binding]; other site 754035005717 Mg2+ binding site [ion binding]; other site 754035005718 G-X-G motif; other site 754035005719 Response regulator receiver domain; Region: Response_reg; pfam00072 754035005720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035005721 active site 754035005722 phosphorylation site [posttranslational modification] 754035005723 intermolecular recognition site; other site 754035005724 dimerization interface [polypeptide binding]; other site 754035005725 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 754035005726 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 754035005727 NADP binding site [chemical binding]; other site 754035005728 dimer interface [polypeptide binding]; other site 754035005729 lipoprotein signal peptidase; Provisional; Region: PRK14795 754035005730 lipoprotein signal peptidase; Provisional; Region: PRK14787 754035005731 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754035005732 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 754035005733 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754035005734 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 754035005735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035005736 S-adenosylmethionine binding site [chemical binding]; other site 754035005737 hypothetical protein; Provisional; Region: PRK02268 754035005738 ornithine cyclodeaminase; Validated; Region: PRK06141 754035005739 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035005740 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754035005741 IHF dimer interface [polypeptide binding]; other site 754035005742 IHF - DNA interface [nucleotide binding]; other site 754035005743 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754035005744 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 754035005745 tandem repeat interface [polypeptide binding]; other site 754035005746 oligomer interface [polypeptide binding]; other site 754035005747 active site residues [active] 754035005748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 754035005749 OstA-like protein; Region: OstA; pfam03968 754035005750 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 754035005751 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 754035005752 Walker A/P-loop; other site 754035005753 ATP binding site [chemical binding]; other site 754035005754 Q-loop/lid; other site 754035005755 ABC transporter signature motif; other site 754035005756 Walker B; other site 754035005757 D-loop; other site 754035005758 H-loop/switch region; other site 754035005759 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 754035005760 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 754035005761 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 754035005762 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 754035005763 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 754035005764 30S subunit binding site; other site 754035005765 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754035005766 active site 754035005767 phosphorylation site [posttranslational modification] 754035005768 Uncharacterized small protein [Function unknown]; Region: COG5568 754035005769 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754035005770 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754035005771 putative dimer interface [polypeptide binding]; other site 754035005772 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 754035005773 active site 754035005774 tetramer interface [polypeptide binding]; other site 754035005775 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035005776 amidase; Provisional; Region: PRK07486 754035005777 Amidase; Region: Amidase; cl11426 754035005778 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035005779 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 754035005780 substrate binding site [chemical binding]; other site 754035005781 dimer interface [polypeptide binding]; other site 754035005782 ATP binding site [chemical binding]; other site 754035005783 Helix-turn-helix domain; Region: HTH_18; pfam12833 754035005784 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 754035005785 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754035005786 DNA binding site [nucleotide binding] 754035005787 active site 754035005788 Integral membrane protein [Function unknown]; Region: COG5488 754035005789 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 754035005790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754035005791 minor groove reading motif; other site 754035005792 helix-hairpin-helix signature motif; other site 754035005793 substrate binding pocket [chemical binding]; other site 754035005794 active site 754035005795 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 754035005796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035005797 Transcriptional regulator [Transcription]; Region: IclR; COG1414 754035005798 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 754035005799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 754035005800 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 754035005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 754035005802 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 754035005803 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754035005804 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 754035005805 active site 754035005806 citrylCoA binding site [chemical binding]; other site 754035005807 oxalacetate binding site [chemical binding]; other site 754035005808 coenzyme A binding site [chemical binding]; other site 754035005809 catalytic triad [active] 754035005810 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 754035005811 nudix motif; other site 754035005812 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 754035005813 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 754035005814 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 754035005815 Flavoprotein; Region: Flavoprotein; pfam02441 754035005816 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 754035005817 ABC1 family; Region: ABC1; cl17513 754035005818 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 754035005819 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 754035005820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035005821 S-adenosylmethionine binding site [chemical binding]; other site 754035005822 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 754035005823 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 754035005824 active site 754035005825 purine riboside binding site [chemical binding]; other site 754035005826 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035005827 active site 754035005828 Predicted aspartyl protease [General function prediction only]; Region: COG3577 754035005829 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 754035005830 catalytic motif [active] 754035005831 Catalytic residue [active] 754035005832 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 754035005833 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754035005834 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754035005835 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 754035005836 purine nucleoside phosphorylase; Provisional; Region: PRK08202 754035005837 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 754035005838 active site 754035005839 catalytic motif [active] 754035005840 Zn binding site [ion binding]; other site 754035005841 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035005842 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035005843 TM-ABC transporter signature motif; other site 754035005844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035005845 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035005846 TM-ABC transporter signature motif; other site 754035005847 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035005848 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035005849 Walker A/P-loop; other site 754035005850 ATP binding site [chemical binding]; other site 754035005851 Q-loop/lid; other site 754035005852 ABC transporter signature motif; other site 754035005853 Walker B; other site 754035005854 D-loop; other site 754035005855 H-loop/switch region; other site 754035005856 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035005857 hypothetical protein; Provisional; Region: PRK00736 754035005858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035005859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035005860 Coenzyme A binding pocket [chemical binding]; other site 754035005861 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035005862 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 754035005863 ligand binding site [chemical binding]; other site 754035005864 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 754035005865 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035005866 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035005867 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035005868 ligand binding site [chemical binding]; other site 754035005869 flexible hinge region; other site 754035005870 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035005871 non-specific DNA interactions [nucleotide binding]; other site 754035005872 DNA binding site [nucleotide binding] 754035005873 sequence specific DNA binding site [nucleotide binding]; other site 754035005874 putative cAMP binding site [chemical binding]; other site 754035005875 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 754035005876 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 754035005877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754035005878 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754035005879 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 754035005880 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 754035005881 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 754035005882 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 754035005883 Ligand Binding Site [chemical binding]; other site 754035005884 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 754035005885 GAF domain; Region: GAF_3; pfam13492 754035005886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035005887 dimer interface [polypeptide binding]; other site 754035005888 phosphorylation site [posttranslational modification] 754035005889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035005890 ATP binding site [chemical binding]; other site 754035005891 Mg2+ binding site [ion binding]; other site 754035005892 G-X-G motif; other site 754035005893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035005894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035005895 active site 754035005896 phosphorylation site [posttranslational modification] 754035005897 intermolecular recognition site; other site 754035005898 dimerization interface [polypeptide binding]; other site 754035005899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035005900 DNA binding site [nucleotide binding] 754035005901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035005902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035005903 putative substrate translocation pore; other site 754035005904 Protein of unknown function (DUF992); Region: DUF992; pfam06186 754035005905 Protein of unknown function (DUF992); Region: DUF992; pfam06186 754035005906 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 754035005907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035005908 TPR motif; other site 754035005909 binding surface 754035005910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035005911 binding surface 754035005912 TPR motif; other site 754035005913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035005914 binding surface 754035005915 TPR motif; other site 754035005916 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 754035005917 Proteins containing SET domain [General function prediction only]; Region: COG2940 754035005918 SET domain; Region: SET; pfam00856 754035005919 short chain dehydrogenase; Provisional; Region: PRK07478 754035005920 classical (c) SDRs; Region: SDR_c; cd05233 754035005921 NAD(P) binding site [chemical binding]; other site 754035005922 active site 754035005923 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 754035005924 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035005925 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 754035005926 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 754035005927 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 754035005928 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035005929 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 754035005930 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 754035005931 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035005932 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035005933 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035005934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035005935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035005936 WHG domain; Region: WHG; pfam13305 754035005937 short chain dehydrogenase; Provisional; Region: PRK06172 754035005938 classical (c) SDRs; Region: SDR_c; cd05233 754035005939 NAD(P) binding site [chemical binding]; other site 754035005940 active site 754035005941 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 754035005942 Phosphotransferase enzyme family; Region: APH; pfam01636 754035005943 putative active site [active] 754035005944 putative substrate binding site [chemical binding]; other site 754035005945 ATP binding site [chemical binding]; other site 754035005946 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 754035005947 putative active site [active] 754035005948 putative catalytic site [active] 754035005949 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 754035005950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035005951 NAD(P) binding site [chemical binding]; other site 754035005952 active site 754035005953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035005954 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 754035005955 FAD binding site [chemical binding]; other site 754035005956 substrate binding site [chemical binding]; other site 754035005957 catalytic base [active] 754035005958 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035005959 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 754035005960 NADP binding site [chemical binding]; other site 754035005961 dimer interface [polypeptide binding]; other site 754035005962 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754035005963 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 754035005964 Ligand binding site; other site 754035005965 Putative Catalytic site; other site 754035005966 DXD motif; other site 754035005967 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 754035005968 putative active site [active] 754035005969 YdjC motif; other site 754035005970 Mg binding site [ion binding]; other site 754035005971 putative homodimer interface [polypeptide binding]; other site 754035005972 Predicted membrane protein [Function unknown]; Region: COG2246 754035005973 GtrA-like protein; Region: GtrA; pfam04138 754035005974 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035005975 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035005976 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035005977 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035005978 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035005979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035005980 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035005981 putative active site [active] 754035005982 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 754035005983 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 754035005984 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754035005985 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754035005986 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035005987 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 754035005988 putative active site [active] 754035005989 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 754035005990 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 754035005991 NAD(P) binding site [chemical binding]; other site 754035005992 catalytic residues [active] 754035005993 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 754035005994 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 754035005995 putative active site [active] 754035005996 metal binding site [ion binding]; metal-binding site 754035005997 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035005998 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035005999 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035006000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006001 putative PBP binding loops; other site 754035006002 dimer interface [polypeptide binding]; other site 754035006003 ABC-ATPase subunit interface; other site 754035006004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035006005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006006 dimer interface [polypeptide binding]; other site 754035006007 conserved gate region; other site 754035006008 putative PBP binding loops; other site 754035006009 ABC-ATPase subunit interface; other site 754035006010 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035006011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035006012 Walker A/P-loop; other site 754035006013 ATP binding site [chemical binding]; other site 754035006014 Q-loop/lid; other site 754035006015 ABC transporter signature motif; other site 754035006016 Walker B; other site 754035006017 D-loop; other site 754035006018 H-loop/switch region; other site 754035006019 TOBE domain; Region: TOBE_2; pfam08402 754035006020 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 754035006021 Preprotein translocase subunit Sec66; Region: Sec66; cl02341 754035006022 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 754035006023 putative catalytic site [active] 754035006024 putative metal binding site [ion binding]; other site 754035006025 putative phosphate binding site [ion binding]; other site 754035006026 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 754035006027 EamA-like transporter family; Region: EamA; pfam00892 754035006028 putative sialic acid transporter; Region: 2A0112; TIGR00891 754035006029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035006030 putative substrate translocation pore; other site 754035006031 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 754035006032 choline dehydrogenase; Validated; Region: PRK02106 754035006033 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035006034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 754035006035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035006036 NAD(P) binding site [chemical binding]; other site 754035006037 active site 754035006038 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035006039 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035006040 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035006041 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035006042 Walker A/P-loop; other site 754035006043 ATP binding site [chemical binding]; other site 754035006044 Q-loop/lid; other site 754035006045 ABC transporter signature motif; other site 754035006046 Walker B; other site 754035006047 D-loop; other site 754035006048 H-loop/switch region; other site 754035006049 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035006050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006051 dimer interface [polypeptide binding]; other site 754035006052 conserved gate region; other site 754035006053 putative PBP binding loops; other site 754035006054 ABC-ATPase subunit interface; other site 754035006055 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035006056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006057 putative PBP binding loops; other site 754035006058 dimer interface [polypeptide binding]; other site 754035006059 ABC-ATPase subunit interface; other site 754035006060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035006061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035006062 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035006063 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 754035006064 NAD(P) binding site [chemical binding]; other site 754035006065 catalytic residues [active] 754035006066 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 754035006067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035006068 substrate binding site [chemical binding]; other site 754035006069 oxyanion hole (OAH) forming residues; other site 754035006070 trimer interface [polypeptide binding]; other site 754035006071 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 754035006072 Coenzyme A transferase; Region: CoA_trans; smart00882 754035006073 Coenzyme A transferase; Region: CoA_trans; cl17247 754035006074 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035006075 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035006076 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035006077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035006078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035006079 DNA binding site [nucleotide binding] 754035006080 domain linker motif; other site 754035006081 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 754035006082 putative dimerization interface [polypeptide binding]; other site 754035006083 putative ligand binding site [chemical binding]; other site 754035006084 Protein of unknown function (DUF993); Region: DUF993; pfam06187 754035006085 Response regulator receiver domain; Region: Response_reg; pfam00072 754035006086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006087 active site 754035006088 phosphorylation site [posttranslational modification] 754035006089 intermolecular recognition site; other site 754035006090 dimerization interface [polypeptide binding]; other site 754035006091 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 754035006092 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035006093 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 754035006094 active site 754035006095 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 754035006096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035006097 Serine hydrolase; Region: Ser_hydrolase; cl17834 754035006098 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754035006099 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754035006100 putative dimer interface [polypeptide binding]; other site 754035006101 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 754035006102 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 754035006103 tetramer interface [polypeptide binding]; other site 754035006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035006105 catalytic residue [active] 754035006106 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 754035006107 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 754035006108 active site 754035006109 dimer interface [polypeptide binding]; other site 754035006110 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 754035006111 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 754035006112 active site 754035006113 FMN binding site [chemical binding]; other site 754035006114 substrate binding site [chemical binding]; other site 754035006115 3Fe-4S cluster binding site [ion binding]; other site 754035006116 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 754035006117 domain interface; other site 754035006118 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 754035006119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035006120 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 754035006121 active site 754035006122 catalytic triad [active] 754035006123 oxyanion hole [active] 754035006124 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 754035006125 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035006126 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035006127 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035006128 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 754035006129 active site 754035006130 tetramer interface; other site 754035006131 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 754035006132 KpsF/GutQ family protein; Region: kpsF; TIGR00393 754035006133 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 754035006134 putative active site [active] 754035006135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 754035006136 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 754035006137 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754035006138 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 754035006139 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035006140 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035006141 ferrochelatase; Reviewed; Region: hemH; PRK00035 754035006142 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 754035006143 C-terminal domain interface [polypeptide binding]; other site 754035006144 active site 754035006145 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 754035006146 active site 754035006147 N-terminal domain interface [polypeptide binding]; other site 754035006148 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 754035006149 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 754035006150 active site 754035006151 metal binding site [ion binding]; metal-binding site 754035006152 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754035006153 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 754035006154 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754035006155 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 754035006156 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 754035006157 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 754035006158 hypothetical protein; Provisional; Region: PRK07546 754035006159 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754035006160 substrate-cofactor binding pocket; other site 754035006161 homodimer interface [polypeptide binding]; other site 754035006162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035006163 catalytic residue [active] 754035006164 aminodeoxychorismate synthase; Provisional; Region: PRK07508 754035006165 chorismate binding enzyme; Region: Chorismate_bind; cl10555 754035006166 Uncharacterized conserved protein [Function unknown]; Region: COG3743 754035006167 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 754035006168 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 754035006169 active site 754035006170 Zn binding site [ion binding]; other site 754035006171 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 754035006172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006173 active site 754035006174 phosphorylation site [posttranslational modification] 754035006175 intermolecular recognition site; other site 754035006176 dimerization interface [polypeptide binding]; other site 754035006177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035006178 Walker A motif; other site 754035006179 ATP binding site [chemical binding]; other site 754035006180 Walker B motif; other site 754035006181 arginine finger; other site 754035006182 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035006183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 754035006184 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 754035006185 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 754035006186 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 754035006187 active site 754035006188 intersubunit interface [polypeptide binding]; other site 754035006189 catalytic residue [active] 754035006190 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 754035006191 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 754035006192 active site residue [active] 754035006193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 754035006194 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 754035006195 putative metal binding site [ion binding]; other site 754035006196 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 754035006197 classical (c) SDRs; Region: SDR_c; cd05233 754035006198 NAD(P) binding site [chemical binding]; other site 754035006199 active site 754035006200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 754035006201 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035006202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035006203 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035006204 dimerization interface [polypeptide binding]; other site 754035006205 substrate binding pocket [chemical binding]; other site 754035006206 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035006207 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035006208 substrate binding pocket [chemical binding]; other site 754035006209 membrane-bound complex binding site; other site 754035006210 hinge residues; other site 754035006211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006212 dimer interface [polypeptide binding]; other site 754035006213 conserved gate region; other site 754035006214 putative PBP binding loops; other site 754035006215 ABC-ATPase subunit interface; other site 754035006216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035006217 aspartate aminotransferase; Provisional; Region: PRK05764 754035006218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035006219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035006220 homodimer interface [polypeptide binding]; other site 754035006221 catalytic residue [active] 754035006222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035006223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035006224 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 754035006225 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754035006226 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035006227 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 754035006228 putative NAD(P) binding site [chemical binding]; other site 754035006229 active site 754035006230 putative substrate binding site [chemical binding]; other site 754035006231 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 754035006232 High-affinity nickel-transport protein; Region: NicO; cl00964 754035006233 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 754035006234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035006235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035006236 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035006237 putative effector binding pocket; other site 754035006238 dimerization interface [polypeptide binding]; other site 754035006239 amidase; Provisional; Region: PRK08310 754035006240 indole-3-acetamide amidohydrolase; Region: PLN02722 754035006241 speF leader; Mesau_01977 754035006242 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 754035006243 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 754035006244 active site 754035006245 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035006246 dimer interface [polypeptide binding]; other site 754035006247 catalytic residues [active] 754035006248 substrate binding site [chemical binding]; other site 754035006249 Predicted acetyltransferase [General function prediction only]; Region: COG3153 754035006250 Coenzyme A binding pocket [chemical binding]; other site 754035006251 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 754035006252 ABC transporter G family member; Provisional; Region: PLN03140 754035006253 Rod binding protein; Region: Rod-binding; pfam10135 754035006254 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 754035006255 Bacterial transcriptional activator domain; Region: BTAD; smart01043 754035006256 Predicted integral membrane protein [Function unknown]; Region: COG5616 754035006257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035006258 binding surface 754035006259 EamA-like transporter family; Region: EamA; pfam00892 754035006260 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 754035006261 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 754035006262 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 754035006263 FHIPEP family; Region: FHIPEP; pfam00771 754035006264 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754035006265 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754035006266 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 754035006267 Cl- selectivity filter; other site 754035006268 Cl- binding residues [ion binding]; other site 754035006269 pore gating glutamate residue; other site 754035006270 dimer interface [polypeptide binding]; other site 754035006271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 754035006272 Transmembrane secretion effector; Region: MFS_3; pfam05977 754035006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035006274 putative substrate translocation pore; other site 754035006275 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 754035006276 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 754035006277 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 754035006278 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 754035006279 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 754035006280 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 754035006281 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 754035006282 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 754035006283 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 754035006284 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 754035006285 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754035006286 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 754035006287 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754035006288 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 754035006289 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754035006290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035006291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 754035006292 active site 754035006293 dimerization interface [polypeptide binding]; other site 754035006294 DNA binding site [nucleotide binding] 754035006295 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 754035006296 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 754035006297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035006298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035006299 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 754035006300 chemotaxis protein; Reviewed; Region: PRK12798 754035006301 flagellar motor protein MotB; Validated; Region: motB; PRK05996 754035006302 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 754035006303 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754035006304 ligand binding site [chemical binding]; other site 754035006305 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 754035006306 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 754035006307 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 754035006308 flagellin; Reviewed; Region: PRK12687 754035006309 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 754035006310 flagellin; Reviewed; Region: PRK12687 754035006311 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 754035006312 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 754035006313 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 754035006314 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 754035006315 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 754035006316 Uncharacterized conserved protein [Function unknown]; Region: COG3334 754035006317 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 754035006318 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 754035006319 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 754035006320 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 754035006321 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 754035006322 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 754035006323 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754035006324 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 754035006325 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 754035006326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754035006327 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 754035006328 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754035006329 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 754035006330 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754035006331 Walker A motif; other site 754035006332 ATP binding site [chemical binding]; other site 754035006333 Walker B motif; other site 754035006334 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 754035006335 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754035006336 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 754035006337 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 754035006338 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 754035006339 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 754035006340 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 754035006341 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 754035006342 flagellar motor protein MotA; Validated; Region: PRK09110 754035006343 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 754035006344 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 754035006345 flagellar motor switch protein FliN; Region: fliN; TIGR02480 754035006346 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 754035006347 FliG C-terminal domain; Region: FliG_C; pfam01706 754035006348 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 754035006349 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 754035006350 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 754035006351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035006352 DNA binding residues [nucleotide binding] 754035006353 dimerization interface [polypeptide binding]; other site 754035006354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035006355 DNA binding residues [nucleotide binding] 754035006356 dimerization interface [polypeptide binding]; other site 754035006357 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 754035006358 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 754035006359 active site 754035006360 Zn binding site [ion binding]; other site 754035006361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035006362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035006363 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 754035006364 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 754035006365 active site 754035006366 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035006367 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 754035006368 Walker A/P-loop; other site 754035006369 ATP binding site [chemical binding]; other site 754035006370 Q-loop/lid; other site 754035006371 ABC transporter signature motif; other site 754035006372 Walker B; other site 754035006373 D-loop; other site 754035006374 H-loop/switch region; other site 754035006375 TOBE domain; Region: TOBE_2; pfam08402 754035006376 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035006377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006378 dimer interface [polypeptide binding]; other site 754035006379 conserved gate region; other site 754035006380 putative PBP binding loops; other site 754035006381 ABC-ATPase subunit interface; other site 754035006382 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035006383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006384 dimer interface [polypeptide binding]; other site 754035006385 conserved gate region; other site 754035006386 putative PBP binding loops; other site 754035006387 ABC-ATPase subunit interface; other site 754035006388 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035006389 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035006390 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035006391 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035006392 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035006393 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035006394 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 754035006395 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 754035006396 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 754035006397 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 754035006398 RNA binding site [nucleotide binding]; other site 754035006399 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035006400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035006401 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 754035006402 dimerization interface [polypeptide binding]; other site 754035006403 substrate binding pocket [chemical binding]; other site 754035006404 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 754035006405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035006406 FAD binding site [chemical binding]; other site 754035006407 substrate binding pocket [chemical binding]; other site 754035006408 catalytic base [active] 754035006409 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035006410 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 754035006411 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 754035006412 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 754035006413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 754035006414 Uncharacterized conserved protein [Function unknown]; Region: COG2308 754035006415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 754035006416 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 754035006417 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035006418 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 754035006419 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 754035006420 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035006421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035006422 active site 754035006423 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 754035006424 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 754035006425 active site 754035006426 DNA binding site [nucleotide binding] 754035006427 Int/Topo IB signature motif; other site 754035006428 catalytic residues [active] 754035006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 754035006430 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 754035006431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035006432 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 754035006433 DNA binding residues [nucleotide binding] 754035006434 aldehyde dehydrogenase family 7 member; Region: PLN02315 754035006435 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 754035006436 tetrameric interface [polypeptide binding]; other site 754035006437 NAD binding site [chemical binding]; other site 754035006438 catalytic residues [active] 754035006439 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 754035006440 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 754035006441 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 754035006442 DctM-like transporters; Region: DctM; pfam06808 754035006443 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 754035006444 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 754035006445 [4Fe-4S] binding site [ion binding]; other site 754035006446 molybdopterin cofactor binding site; other site 754035006447 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 754035006448 molybdopterin cofactor binding site; other site 754035006449 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754035006450 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 754035006451 [2Fe-2S] cluster binding site [ion binding]; other site 754035006452 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 754035006453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035006454 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754035006455 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754035006456 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754035006457 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035006458 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035006459 Walker A/P-loop; other site 754035006460 ATP binding site [chemical binding]; other site 754035006461 Q-loop/lid; other site 754035006462 ABC transporter signature motif; other site 754035006463 Walker B; other site 754035006464 D-loop; other site 754035006465 H-loop/switch region; other site 754035006466 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035006467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006468 putative PBP binding loops; other site 754035006469 dimer interface [polypeptide binding]; other site 754035006470 ABC-ATPase subunit interface; other site 754035006471 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 754035006472 NMT1-like family; Region: NMT1_2; pfam13379 754035006473 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 754035006474 NMT1-like family; Region: NMT1_2; pfam13379 754035006475 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 754035006476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006477 active site 754035006478 phosphorylation site [posttranslational modification] 754035006479 intermolecular recognition site; other site 754035006480 ANTAR domain; Region: ANTAR; pfam03861 754035006481 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 754035006482 putative catalytic site [active] 754035006483 putative metal binding site [ion binding]; other site 754035006484 putative phosphate binding site [ion binding]; other site 754035006485 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 754035006486 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 754035006487 putative active site [active] 754035006488 catalytic site [active] 754035006489 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 754035006490 putative active site [active] 754035006491 catalytic site [active] 754035006492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035006493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035006494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035006495 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 754035006496 trimer interface [polypeptide binding]; other site 754035006497 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 754035006498 trimer interface [polypeptide binding]; other site 754035006499 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 754035006500 trimer interface [polypeptide binding]; other site 754035006501 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 754035006502 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 754035006503 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 754035006504 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 754035006505 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 754035006506 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 754035006507 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035006508 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035006509 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035006510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035006511 DNA-binding site [nucleotide binding]; DNA binding site 754035006512 FCD domain; Region: FCD; pfam07729 754035006513 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035006514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035006515 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754035006516 hypothetical protein; Provisional; Region: PRK07236 754035006517 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 754035006518 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035006519 Amino acid synthesis; Region: AA_synth; pfam06684 754035006520 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 754035006521 substrate binding site [chemical binding]; other site 754035006522 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 754035006523 intersubunit interface [polypeptide binding]; other site 754035006524 active site 754035006525 Zn2+ binding site [ion binding]; other site 754035006526 choline dehydrogenase; Validated; Region: PRK02106 754035006527 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035006528 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 754035006529 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035006530 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035006531 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035006532 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035006533 Walker A/P-loop; other site 754035006534 ATP binding site [chemical binding]; other site 754035006535 Q-loop/lid; other site 754035006536 ABC transporter signature motif; other site 754035006537 Walker B; other site 754035006538 D-loop; other site 754035006539 H-loop/switch region; other site 754035006540 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006542 dimer interface [polypeptide binding]; other site 754035006543 conserved gate region; other site 754035006544 ABC-ATPase subunit interface; other site 754035006545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 754035006546 NMT1/THI5 like; Region: NMT1; pfam09084 754035006547 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035006548 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035006549 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035006550 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035006551 Walker A/P-loop; other site 754035006552 ATP binding site [chemical binding]; other site 754035006553 Q-loop/lid; other site 754035006554 ABC transporter signature motif; other site 754035006555 Walker B; other site 754035006556 D-loop; other site 754035006557 H-loop/switch region; other site 754035006558 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035006559 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035006560 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035006561 TM-ABC transporter signature motif; other site 754035006562 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035006563 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035006564 TM-ABC transporter signature motif; other site 754035006565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035006566 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 754035006567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035006568 catalytic residue [active] 754035006569 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035006570 classical (c) SDRs; Region: SDR_c; cd05233 754035006571 NAD(P) binding site [chemical binding]; other site 754035006572 active site 754035006573 S-formylglutathione hydrolase; Region: PLN02442 754035006574 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 754035006575 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035006576 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035006577 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035006578 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 754035006579 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 754035006580 Ligand Binding Site [chemical binding]; other site 754035006581 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 754035006582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035006583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006584 active site 754035006585 phosphorylation site [posttranslational modification] 754035006586 intermolecular recognition site; other site 754035006587 dimerization interface [polypeptide binding]; other site 754035006588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035006589 DNA binding site [nucleotide binding] 754035006590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006591 Response regulator receiver domain; Region: Response_reg; pfam00072 754035006592 active site 754035006593 phosphorylation site [posttranslational modification] 754035006594 intermolecular recognition site; other site 754035006595 dimerization interface [polypeptide binding]; other site 754035006596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 754035006597 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 754035006598 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754035006599 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 754035006600 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754035006601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035006602 dimerization interface [polypeptide binding]; other site 754035006603 putative DNA binding site [nucleotide binding]; other site 754035006604 putative Zn2+ binding site [ion binding]; other site 754035006605 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 754035006606 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 754035006607 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 754035006608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754035006609 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 754035006610 NAD binding site [chemical binding]; other site 754035006611 homodimer interface [polypeptide binding]; other site 754035006612 homotetramer interface [polypeptide binding]; other site 754035006613 active site 754035006614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035006615 Coenzyme A binding pocket [chemical binding]; other site 754035006616 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 754035006617 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 754035006618 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 754035006619 putative dimer interface [polypeptide binding]; other site 754035006620 N-terminal domain interface [polypeptide binding]; other site 754035006621 putative substrate binding pocket (H-site) [chemical binding]; other site 754035006622 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 754035006623 nudix motif; other site 754035006624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035006625 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 754035006626 putative active site [active] 754035006627 putative metal binding site [ion binding]; other site 754035006628 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754035006629 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035006630 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754035006631 catalytic site [active] 754035006632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035006633 TPR motif; other site 754035006634 binding surface 754035006635 2-isopropylmalate synthase; Validated; Region: PRK03739 754035006636 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 754035006637 active site 754035006638 catalytic residues [active] 754035006639 metal binding site [ion binding]; metal-binding site 754035006640 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 754035006641 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 754035006642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 754035006643 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035006644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035006645 putative substrate translocation pore; other site 754035006646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035006647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035006648 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 754035006649 putative effector binding pocket; other site 754035006650 putative dimerization interface [polypeptide binding]; other site 754035006651 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 754035006652 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 754035006653 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 754035006654 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754035006655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754035006656 classical (c) SDRs; Region: SDR_c; cd05233 754035006657 NAD(P) binding site [chemical binding]; other site 754035006658 active site 754035006659 Uncharacterized conserved protein [Function unknown]; Region: COG1416 754035006660 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 754035006661 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 754035006662 oligomeric interface; other site 754035006663 putative active site [active] 754035006664 homodimer interface [polypeptide binding]; other site 754035006665 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754035006666 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 754035006667 anthranilate synthase; Provisional; Region: PRK13566 754035006668 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 754035006669 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754035006670 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754035006671 glutamine binding [chemical binding]; other site 754035006672 catalytic triad [active] 754035006673 Predicted deacylase [General function prediction only]; Region: COG3608 754035006674 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 754035006675 active site 754035006676 Zn binding site [ion binding]; other site 754035006677 MFS transport protein AraJ; Provisional; Region: PRK10091 754035006678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035006679 putative substrate translocation pore; other site 754035006680 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035006681 mercuric reductase; Validated; Region: PRK06370 754035006682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035006683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035006684 Predicted membrane protein [Function unknown]; Region: COG3918 754035006685 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 754035006686 putative C-terminal domain interface [polypeptide binding]; other site 754035006687 putative GSH binding site (G-site) [chemical binding]; other site 754035006688 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035006689 putative dimer interface [polypeptide binding]; other site 754035006690 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 754035006691 dimer interface [polypeptide binding]; other site 754035006692 N-terminal domain interface [polypeptide binding]; other site 754035006693 putative substrate binding pocket (H-site) [chemical binding]; other site 754035006694 sensor protein QseC; Provisional; Region: PRK10337 754035006695 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 754035006696 HAMP domain; Region: HAMP; pfam00672 754035006697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035006698 dimer interface [polypeptide binding]; other site 754035006699 phosphorylation site [posttranslational modification] 754035006700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035006701 ATP binding site [chemical binding]; other site 754035006702 Mg2+ binding site [ion binding]; other site 754035006703 G-X-G motif; other site 754035006704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035006705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006706 active site 754035006707 phosphorylation site [posttranslational modification] 754035006708 intermolecular recognition site; other site 754035006709 dimerization interface [polypeptide binding]; other site 754035006710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035006711 DNA binding site [nucleotide binding] 754035006712 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 754035006713 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 754035006714 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 754035006715 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 754035006716 conserved cys residue [active] 754035006717 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 754035006718 Isochorismatase family; Region: Isochorismatase; pfam00857 754035006719 catalytic triad [active] 754035006720 conserved cis-peptide bond; other site 754035006721 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 754035006722 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 754035006723 Potassium binding sites [ion binding]; other site 754035006724 Cesium cation binding sites [ion binding]; other site 754035006725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 754035006726 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 754035006727 putative active site [active] 754035006728 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 754035006729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035006730 Walker A motif; other site 754035006731 ATP binding site [chemical binding]; other site 754035006732 Walker B motif; other site 754035006733 hypothetical protein; Validated; Region: PRK09039 754035006734 Cytochrome c2 [Energy production and conversion]; Region: COG3474 754035006735 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 754035006736 thymidine kinase; Provisional; Region: PRK04296 754035006737 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 754035006738 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 754035006739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035006740 dimer interface [polypeptide binding]; other site 754035006741 conserved gate region; other site 754035006742 putative PBP binding loops; other site 754035006743 ABC-ATPase subunit interface; other site 754035006744 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 754035006745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035006746 Walker A/P-loop; other site 754035006747 ATP binding site [chemical binding]; other site 754035006748 Q-loop/lid; other site 754035006749 ABC transporter signature motif; other site 754035006750 Walker B; other site 754035006751 D-loop; other site 754035006752 H-loop/switch region; other site 754035006753 HAMP domain; Region: HAMP; pfam00672 754035006754 dimerization interface [polypeptide binding]; other site 754035006755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035006756 ATP binding site [chemical binding]; other site 754035006757 Mg2+ binding site [ion binding]; other site 754035006758 G-X-G motif; other site 754035006759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006761 active site 754035006762 phosphorylation site [posttranslational modification] 754035006763 intermolecular recognition site; other site 754035006764 dimerization interface [polypeptide binding]; other site 754035006765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035006766 DNA binding site [nucleotide binding] 754035006767 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 754035006768 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 754035006769 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 754035006770 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 754035006771 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 754035006772 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 754035006773 Protein of unknown function DUF58; Region: DUF58; pfam01882 754035006774 MoxR-like ATPases [General function prediction only]; Region: COG0714 754035006775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754035006776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 754035006777 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 754035006778 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 754035006779 putative active site [active] 754035006780 putative CoA binding site [chemical binding]; other site 754035006781 nudix motif; other site 754035006782 metal binding site [ion binding]; metal-binding site 754035006783 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 754035006784 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754035006785 active site 754035006786 NTP binding site [chemical binding]; other site 754035006787 metal binding triad [ion binding]; metal-binding site 754035006788 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754035006789 Predicted small metal-binding protein [Function unknown]; Region: COG5466 754035006790 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 754035006791 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 754035006792 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 754035006793 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 754035006794 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 754035006795 DNA binding residues [nucleotide binding] 754035006796 dimer interface [polypeptide binding]; other site 754035006797 [2Fe-2S] cluster binding site [ion binding]; other site 754035006798 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 754035006799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035006800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035006801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035006802 Walker A/P-loop; other site 754035006803 ATP binding site [chemical binding]; other site 754035006804 Q-loop/lid; other site 754035006805 ABC transporter signature motif; other site 754035006806 Walker B; other site 754035006807 D-loop; other site 754035006808 H-loop/switch region; other site 754035006809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035006810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035006811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035006812 Walker A/P-loop; other site 754035006813 ATP binding site [chemical binding]; other site 754035006814 Q-loop/lid; other site 754035006815 ABC transporter signature motif; other site 754035006816 Walker B; other site 754035006817 D-loop; other site 754035006818 H-loop/switch region; other site 754035006819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035006820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035006821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035006822 Coenzyme A binding pocket [chemical binding]; other site 754035006823 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 754035006824 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 754035006825 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 754035006826 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 754035006827 [2Fe-2S] cluster binding site [ion binding]; other site 754035006828 cytochrome b; Provisional; Region: CYTB; MTH00191 754035006829 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 754035006830 Qi binding site; other site 754035006831 intrachain domain interface; other site 754035006832 interchain domain interface [polypeptide binding]; other site 754035006833 heme bH binding site [chemical binding]; other site 754035006834 heme bL binding site [chemical binding]; other site 754035006835 Qo binding site; other site 754035006836 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 754035006837 interchain domain interface [polypeptide binding]; other site 754035006838 intrachain domain interface; other site 754035006839 Qi binding site; other site 754035006840 Qo binding site; other site 754035006841 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 754035006842 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 754035006843 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754035006844 active site 754035006845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035006846 active site 754035006847 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 754035006848 putative active site [active] 754035006849 putative catalytic site [active] 754035006850 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 754035006851 putative active site [active] 754035006852 putative catalytic site [active] 754035006853 xanthine permease; Region: pbuX; TIGR03173 754035006854 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035006855 guanine deaminase; Region: guan_deamin; TIGR02967 754035006856 active site 754035006857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035006858 non-specific DNA binding site [nucleotide binding]; other site 754035006859 salt bridge; other site 754035006860 sequence-specific DNA binding site [nucleotide binding]; other site 754035006861 GTP-binding protein YchF; Reviewed; Region: PRK09601 754035006862 YchF GTPase; Region: YchF; cd01900 754035006863 G1 box; other site 754035006864 GTP/Mg2+ binding site [chemical binding]; other site 754035006865 Switch I region; other site 754035006866 G2 box; other site 754035006867 Switch II region; other site 754035006868 G3 box; other site 754035006869 G4 box; other site 754035006870 G5 box; other site 754035006871 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 754035006872 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 754035006873 putative active site [active] 754035006874 catalytic residue [active] 754035006875 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 754035006876 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 754035006877 5S rRNA interface [nucleotide binding]; other site 754035006878 CTC domain interface [polypeptide binding]; other site 754035006879 L16 interface [polypeptide binding]; other site 754035006880 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035006881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035006882 putative Zn2+ binding site [ion binding]; other site 754035006883 putative DNA binding site [nucleotide binding]; other site 754035006884 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035006885 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035006886 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035006887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035006888 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754035006889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035006890 Helix-turn-helix domain; Region: HTH_18; pfam12833 754035006891 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 754035006892 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 754035006893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035006894 active site 754035006895 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035006896 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035006897 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035006898 active site 754035006899 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 754035006900 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 754035006901 Uncharacterized conserved protein [Function unknown]; Region: COG1565 754035006902 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 754035006903 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 754035006904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 754035006905 Uncharacterized conserved protein [Function unknown]; Region: COG5465 754035006906 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 754035006907 dimer interface [polypeptide binding]; other site 754035006908 putative tRNA-binding site [nucleotide binding]; other site 754035006909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035006910 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 754035006911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035006912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035006913 ATP binding site [chemical binding]; other site 754035006914 Mg2+ binding site [ion binding]; other site 754035006915 G-X-G motif; other site 754035006916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035006918 active site 754035006919 phosphorylation site [posttranslational modification] 754035006920 intermolecular recognition site; other site 754035006921 dimerization interface [polypeptide binding]; other site 754035006922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035006923 DNA binding site [nucleotide binding] 754035006924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035006925 MarR family; Region: MarR_2; pfam12802 754035006926 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754035006927 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 754035006928 homodimer interface [polypeptide binding]; other site 754035006929 substrate-cofactor binding pocket; other site 754035006930 catalytic residue [active] 754035006931 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754035006932 BA14K-like protein; Region: BA14K; pfam07886 754035006933 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035006934 DNA-binding site [nucleotide binding]; DNA binding site 754035006935 RNA-binding motif; other site 754035006936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035006937 DNA-binding site [nucleotide binding]; DNA binding site 754035006938 RNA-binding motif; other site 754035006939 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035006940 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 754035006941 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 754035006942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035006943 TPR motif; other site 754035006944 binding surface 754035006945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 754035006946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035006947 binding surface 754035006948 TPR motif; other site 754035006949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 754035006950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035006951 binding surface 754035006952 TPR motif; other site 754035006953 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 754035006954 Uncharacterized conserved protein [Function unknown]; Region: COG5507 754035006955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 754035006956 putative dimer interface [polypeptide binding]; other site 754035006957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035006958 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035006959 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 754035006960 putative C-terminal domain interface [polypeptide binding]; other site 754035006961 putative GSH binding site (G-site) [chemical binding]; other site 754035006962 putative dimer interface [polypeptide binding]; other site 754035006963 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 754035006964 dimer interface [polypeptide binding]; other site 754035006965 N-terminal domain interface [polypeptide binding]; other site 754035006966 putative substrate binding pocket (H-site) [chemical binding]; other site 754035006967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035006968 sequence-specific DNA binding site [nucleotide binding]; other site 754035006969 salt bridge; other site 754035006970 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 754035006971 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754035006972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035006973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035006974 EamA-like transporter family; Region: EamA; pfam00892 754035006975 excinuclease ABC subunit B; Provisional; Region: PRK05298 754035006976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035006977 ATP binding site [chemical binding]; other site 754035006978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035006979 nucleotide binding region [chemical binding]; other site 754035006980 ATP-binding site [chemical binding]; other site 754035006981 Ultra-violet resistance protein B; Region: UvrB; pfam12344 754035006982 UvrB/uvrC motif; Region: UVR; pfam02151 754035006983 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 754035006984 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 754035006985 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 754035006986 putative active site [active] 754035006987 putative metal binding site [ion binding]; other site 754035006988 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 754035006989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 754035006990 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 754035006991 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 754035006992 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035006993 FAD binding domain; Region: FAD_binding_4; pfam01565 754035006994 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 754035006995 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 754035006996 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 754035006997 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 754035006998 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 754035006999 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035007000 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035007001 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035007002 active site pocket [active] 754035007003 choline dehydrogenase; Validated; Region: PRK02106 754035007004 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035007005 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 754035007006 ATP binding site [chemical binding]; other site 754035007007 active site 754035007008 substrate binding site [chemical binding]; other site 754035007009 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 754035007010 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035007011 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035007012 Predicted flavoprotein [General function prediction only]; Region: COG0431 754035007013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035007014 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 754035007015 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 754035007016 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 754035007017 active site 754035007018 catalytic residues [active] 754035007019 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 754035007020 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 754035007021 Walker A/P-loop; other site 754035007022 ATP binding site [chemical binding]; other site 754035007023 Q-loop/lid; other site 754035007024 ABC transporter signature motif; other site 754035007025 Walker B; other site 754035007026 D-loop; other site 754035007027 H-loop/switch region; other site 754035007028 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754035007029 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035007030 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035007031 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754035007032 Domain of unknown function DUF21; Region: DUF21; pfam01595 754035007033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754035007034 Transporter associated domain; Region: CorC_HlyC; smart01091 754035007035 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 754035007036 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754035007037 putative active site pocket [active] 754035007038 dimerization interface [polypeptide binding]; other site 754035007039 putative catalytic residue [active] 754035007040 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 754035007041 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 754035007042 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 754035007043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035007044 binding surface 754035007045 Tetratricopeptide repeat; Region: TPR_16; pfam13432 754035007046 TPR motif; other site 754035007047 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 754035007048 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754035007049 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754035007050 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754035007051 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754035007052 putative active site [active] 754035007053 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754035007054 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754035007055 putative active site [active] 754035007056 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 754035007057 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 754035007058 NADP binding site [chemical binding]; other site 754035007059 homopentamer interface [polypeptide binding]; other site 754035007060 substrate binding site [chemical binding]; other site 754035007061 active site 754035007062 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 754035007063 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035007064 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 754035007065 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 754035007066 putative ribose interaction site [chemical binding]; other site 754035007067 putative ADP binding site [chemical binding]; other site 754035007068 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 754035007069 active site 754035007070 nucleotide binding site [chemical binding]; other site 754035007071 HIGH motif; other site 754035007072 KMSKS motif; other site 754035007073 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 754035007074 dimer interface [polypeptide binding]; other site 754035007075 active site 754035007076 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 754035007077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035007078 active site 754035007079 motif I; other site 754035007080 motif II; other site 754035007081 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 754035007082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035007083 putative metal binding site; other site 754035007084 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035007085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035007086 putative DNA binding site [nucleotide binding]; other site 754035007087 putative Zn2+ binding site [ion binding]; other site 754035007088 AsnC family; Region: AsnC_trans_reg; pfam01037 754035007089 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 754035007090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035007091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035007092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035007093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007094 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035007095 putative effector binding pocket; other site 754035007096 dimerization interface [polypeptide binding]; other site 754035007097 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035007098 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 754035007099 elongation factor G; Reviewed; Region: PRK12740 754035007100 G1 box; other site 754035007101 putative GEF interaction site [polypeptide binding]; other site 754035007102 GTP/Mg2+ binding site [chemical binding]; other site 754035007103 Switch I region; other site 754035007104 G2 box; other site 754035007105 G3 box; other site 754035007106 Switch II region; other site 754035007107 G4 box; other site 754035007108 G5 box; other site 754035007109 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754035007110 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754035007111 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 754035007112 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035007113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035007114 metal binding site [ion binding]; metal-binding site 754035007115 active site 754035007116 I-site; other site 754035007117 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035007118 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035007119 aspartate aminotransferase; Provisional; Region: PRK05764 754035007120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035007121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035007122 homodimer interface [polypeptide binding]; other site 754035007123 catalytic residue [active] 754035007124 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035007125 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035007126 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035007127 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 754035007128 putative C-terminal domain interface [polypeptide binding]; other site 754035007129 putative GSH binding site (G-site) [chemical binding]; other site 754035007130 putative dimer interface [polypeptide binding]; other site 754035007131 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 754035007132 N-terminal domain interface [polypeptide binding]; other site 754035007133 dimer interface [polypeptide binding]; other site 754035007134 substrate binding pocket (H-site) [chemical binding]; other site 754035007135 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035007136 DNA-binding site [nucleotide binding]; DNA binding site 754035007137 RNA-binding motif; other site 754035007138 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 754035007139 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754035007140 DNA binding site [nucleotide binding] 754035007141 active site 754035007142 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 754035007143 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035007144 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035007145 catalytic residue [active] 754035007146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035007147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035007148 Coenzyme A binding pocket [chemical binding]; other site 754035007149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035007150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035007151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007152 dimer interface [polypeptide binding]; other site 754035007153 conserved gate region; other site 754035007154 putative PBP binding loops; other site 754035007155 ABC-ATPase subunit interface; other site 754035007156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035007157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007158 dimer interface [polypeptide binding]; other site 754035007159 conserved gate region; other site 754035007160 putative PBP binding loops; other site 754035007161 ABC-ATPase subunit interface; other site 754035007162 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 754035007163 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 754035007164 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 754035007165 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 754035007166 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754035007167 homotrimer interaction site [polypeptide binding]; other site 754035007168 putative active site [active] 754035007169 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 754035007170 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035007171 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035007172 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 754035007173 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035007174 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035007175 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 754035007176 IMP binding site; other site 754035007177 dimer interface [polypeptide binding]; other site 754035007178 interdomain contacts; other site 754035007179 partial ornithine binding site; other site 754035007180 Bacterial SH3 domain; Region: SH3_3; pfam08239 754035007181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035007182 putative DNA binding site [nucleotide binding]; other site 754035007183 putative Zn2+ binding site [ion binding]; other site 754035007184 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035007186 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035007187 MarR family; Region: MarR_2; pfam12802 754035007188 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 754035007189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035007190 NAD(P) binding site [chemical binding]; other site 754035007191 active site 754035007192 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035007193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035007194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035007196 dimerization interface [polypeptide binding]; other site 754035007197 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035007198 RibD C-terminal domain; Region: RibD_C; pfam01872 754035007199 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 754035007200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035007201 S-adenosylmethionine binding site [chemical binding]; other site 754035007202 manganese transport protein MntH; Reviewed; Region: PRK00701 754035007203 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 754035007204 manganese transport regulator MntR; Provisional; Region: PRK11050 754035007205 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 754035007206 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 754035007207 Predicted metalloprotease [General function prediction only]; Region: COG2321 754035007208 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 754035007209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035007210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035007211 putative substrate translocation pore; other site 754035007212 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 754035007213 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 754035007214 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 754035007215 catalytic site [active] 754035007216 subunit interface [polypeptide binding]; other site 754035007217 Uncharacterized conserved protein [Function unknown]; Region: COG1610 754035007218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035007219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035007221 dimerization interface [polypeptide binding]; other site 754035007222 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 754035007223 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 754035007224 Predicted acetyltransferase [General function prediction only]; Region: COG3981 754035007225 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 754035007226 Coenzyme A binding pocket [chemical binding]; other site 754035007227 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 754035007228 homodimer interface [polypeptide binding]; other site 754035007229 homotetramer interface [polypeptide binding]; other site 754035007230 active site pocket [active] 754035007231 cleavage site 754035007232 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035007233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035007234 putative substrate translocation pore; other site 754035007235 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 754035007236 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 754035007237 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 754035007238 PhoU domain; Region: PhoU; pfam01895 754035007239 Predicted integral membrane protein [Function unknown]; Region: COG5455 754035007240 DNA primase; Validated; Region: dnaG; PRK05667 754035007241 CHC2 zinc finger; Region: zf-CHC2; pfam01807 754035007242 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 754035007243 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 754035007244 active site 754035007245 metal binding site [ion binding]; metal-binding site 754035007246 interdomain interaction site; other site 754035007247 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 754035007248 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 754035007249 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 754035007250 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754035007251 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 754035007252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035007253 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754035007254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035007255 DNA binding residues [nucleotide binding] 754035007256 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 754035007257 substrate binding pocket [chemical binding]; other site 754035007258 active site 754035007259 Uncharacterized conserved protein [Function unknown]; Region: COG4274 754035007260 EamA-like transporter family; Region: EamA; pfam00892 754035007261 Protein of unknown function, DUF393; Region: DUF393; cl01136 754035007262 Predicted transcriptional regulators [Transcription]; Region: COG1695 754035007263 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 754035007264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035007265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035007266 WHG domain; Region: WHG; pfam13305 754035007267 Transcriptional activator HlyU; Region: HlyU; cl02273 754035007268 Methyltransferase domain; Region: Methyltransf_25; pfam13649 754035007269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035007270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035007271 metal binding site [ion binding]; metal-binding site 754035007272 active site 754035007273 I-site; other site 754035007274 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035007275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035007276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035007277 putative substrate translocation pore; other site 754035007278 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035007279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035007280 putative DNA binding site [nucleotide binding]; other site 754035007281 putative Zn2+ binding site [ion binding]; other site 754035007282 AsnC family; Region: AsnC_trans_reg; pfam01037 754035007283 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 754035007284 Predicted membrane protein [Function unknown]; Region: COG4541 754035007285 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 754035007286 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035007287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035007288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035007290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035007291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035007292 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035007293 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035007294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035007295 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035007296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035007297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035007298 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 754035007299 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035007300 dimer interface [polypeptide binding]; other site 754035007301 active site 754035007302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035007303 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 754035007304 putative dimer interface [polypeptide binding]; other site 754035007305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035007306 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035007307 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035007308 protein binding site [polypeptide binding]; other site 754035007309 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 754035007310 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035007311 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035007312 protein binding site [polypeptide binding]; other site 754035007313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035007314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035007315 DNA binding residues [nucleotide binding] 754035007316 dimerization interface [polypeptide binding]; other site 754035007317 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 754035007318 short chain dehydrogenase; Provisional; Region: PRK08278 754035007319 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 754035007320 NAD(P) binding site [chemical binding]; other site 754035007321 homodimer interface [polypeptide binding]; other site 754035007322 active site 754035007323 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 754035007324 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754035007325 ligand binding site [chemical binding]; other site 754035007326 hypothetical protein; Provisional; Region: PRK05170 754035007327 Uncharacterized conserved protein [Function unknown]; Region: COG2968 754035007328 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 754035007329 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 754035007330 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 754035007331 active site 754035007332 catalytic residues [active] 754035007333 DNA binding site [nucleotide binding] 754035007334 Int/Topo IB signature motif; other site 754035007335 AAA domain; Region: AAA_23; pfam13476 754035007336 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 754035007337 integrase; Provisional; Region: PRK09692 754035007338 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 754035007339 active site 754035007340 Int/Topo IB signature motif; other site 754035007341 Cupin domain; Region: Cupin_2; pfam07883 754035007342 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754035007343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035007344 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035007345 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035007346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007347 dimer interface [polypeptide binding]; other site 754035007348 conserved gate region; other site 754035007349 putative PBP binding loops; other site 754035007350 ABC-ATPase subunit interface; other site 754035007351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035007352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007353 dimer interface [polypeptide binding]; other site 754035007354 conserved gate region; other site 754035007355 putative PBP binding loops; other site 754035007356 ABC-ATPase subunit interface; other site 754035007357 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035007358 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035007359 Walker A/P-loop; other site 754035007360 ATP binding site [chemical binding]; other site 754035007361 Q-loop/lid; other site 754035007362 ABC transporter signature motif; other site 754035007363 Walker B; other site 754035007364 D-loop; other site 754035007365 H-loop/switch region; other site 754035007366 TOBE domain; Region: TOBE_2; pfam08402 754035007367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035007368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035007369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035007370 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035007371 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035007372 active site 754035007373 catalytic tetrad [active] 754035007374 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754035007375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035007376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035007377 alpha-galactosidase; Provisional; Region: PRK15076 754035007378 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 754035007379 NAD binding site [chemical binding]; other site 754035007380 sugar binding site [chemical binding]; other site 754035007381 divalent metal binding site [ion binding]; other site 754035007382 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 754035007383 dimer interface [polypeptide binding]; other site 754035007384 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 754035007385 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 754035007386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035007387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007388 dimer interface [polypeptide binding]; other site 754035007389 conserved gate region; other site 754035007390 putative PBP binding loops; other site 754035007391 ABC-ATPase subunit interface; other site 754035007392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035007393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007394 dimer interface [polypeptide binding]; other site 754035007395 conserved gate region; other site 754035007396 putative PBP binding loops; other site 754035007397 ABC-ATPase subunit interface; other site 754035007398 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 754035007399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035007400 Walker A/P-loop; other site 754035007401 ATP binding site [chemical binding]; other site 754035007402 Q-loop/lid; other site 754035007403 ABC transporter signature motif; other site 754035007404 Walker B; other site 754035007405 D-loop; other site 754035007406 H-loop/switch region; other site 754035007407 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035007408 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035007409 Walker A/P-loop; other site 754035007410 ATP binding site [chemical binding]; other site 754035007411 Q-loop/lid; other site 754035007412 ABC transporter signature motif; other site 754035007413 Walker B; other site 754035007414 D-loop; other site 754035007415 H-loop/switch region; other site 754035007416 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035007417 alpha-galactosidase; Provisional; Region: PRK15076 754035007418 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 754035007419 NAD binding site [chemical binding]; other site 754035007420 sugar binding site [chemical binding]; other site 754035007421 divalent metal binding site [ion binding]; other site 754035007422 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 754035007423 dimer interface [polypeptide binding]; other site 754035007424 zinc-binding protein; Provisional; Region: PRK01343 754035007425 Maf-like protein; Region: Maf; pfam02545 754035007426 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 754035007427 active site 754035007428 dimer interface [polypeptide binding]; other site 754035007429 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 754035007430 rRNA binding site [nucleotide binding]; other site 754035007431 predicted 30S ribosome binding site; other site 754035007432 Low molecular weight phosphatase family; Region: LMWPc; cl00105 754035007433 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 754035007434 active site 754035007435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 754035007436 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 754035007437 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 754035007438 NAD binding site [chemical binding]; other site 754035007439 dimerization interface [polypeptide binding]; other site 754035007440 product binding site; other site 754035007441 substrate binding site [chemical binding]; other site 754035007442 zinc binding site [ion binding]; other site 754035007443 catalytic residues [active] 754035007444 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 754035007445 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 754035007446 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 754035007447 hinge; other site 754035007448 active site 754035007449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 754035007450 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 754035007451 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035007452 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035007453 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035007454 putative active site [active] 754035007455 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 754035007456 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754035007457 metal binding site [ion binding]; metal-binding site 754035007458 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035007459 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035007460 TM-ABC transporter signature motif; other site 754035007461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035007462 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035007463 TM-ABC transporter signature motif; other site 754035007464 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035007465 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035007466 Walker A/P-loop; other site 754035007467 ATP binding site [chemical binding]; other site 754035007468 Q-loop/lid; other site 754035007469 ABC transporter signature motif; other site 754035007470 Walker B; other site 754035007471 D-loop; other site 754035007472 H-loop/switch region; other site 754035007473 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035007474 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035007475 Walker A/P-loop; other site 754035007476 ATP binding site [chemical binding]; other site 754035007477 Q-loop/lid; other site 754035007478 ABC transporter signature motif; other site 754035007479 Walker B; other site 754035007480 D-loop; other site 754035007481 H-loop/switch region; other site 754035007482 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035007483 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 754035007484 ligand binding site [chemical binding]; other site 754035007485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035007486 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 754035007487 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754035007488 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 754035007489 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 754035007490 active site 754035007491 P-loop; other site 754035007492 phosphorylation site [posttranslational modification] 754035007493 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754035007494 active site 754035007495 phosphorylation site [posttranslational modification] 754035007496 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 754035007497 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754035007498 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 754035007499 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754035007500 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 754035007501 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 754035007502 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 754035007503 putative active site [active] 754035007504 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 754035007505 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 754035007506 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754035007507 O-Antigen ligase; Region: Wzy_C; pfam04932 754035007508 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754035007509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035007510 active site 754035007511 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 754035007512 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 754035007513 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 754035007514 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 754035007515 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754035007516 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 754035007517 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 754035007518 Chain length determinant protein; Region: Wzz; pfam02706 754035007519 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 754035007520 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 754035007521 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 754035007522 homodimer interface [polypeptide binding]; other site 754035007523 NADP binding site [chemical binding]; other site 754035007524 substrate binding site [chemical binding]; other site 754035007525 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035007526 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035007527 conserved cys residue [active] 754035007528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035007529 von Willebrand factor type A domain; Region: VWA_2; pfam13519 754035007530 metal ion-dependent adhesion site (MIDAS); other site 754035007531 phosphogluconate dehydratase; Validated; Region: PRK09054 754035007532 6-phosphogluconate dehydratase; Region: edd; TIGR01196 754035007533 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 754035007534 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 754035007535 putative active site [active] 754035007536 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 754035007537 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 754035007538 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 754035007539 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 754035007540 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 754035007541 putative NAD(P) binding site [chemical binding]; other site 754035007542 active site 754035007543 Bacterial SH3 domain; Region: SH3_3; pfam08239 754035007544 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035007545 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035007546 hypothetical protein; Reviewed; Region: PRK12275 754035007547 four helix bundle protein; Region: TIGR02436 754035007548 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754035007549 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754035007550 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035007551 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 754035007552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035007553 motif II; other site 754035007554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035007555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035007556 active site 754035007557 phosphorylation site [posttranslational modification] 754035007558 intermolecular recognition site; other site 754035007559 dimerization interface [polypeptide binding]; other site 754035007560 isocitrate lyase; Provisional; Region: PRK15063 754035007561 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 754035007562 tetramer interface [polypeptide binding]; other site 754035007563 active site 754035007564 Mg2+/Mn2+ binding site [ion binding]; other site 754035007565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035007566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035007567 non-specific DNA binding site [nucleotide binding]; other site 754035007568 salt bridge; other site 754035007569 sequence-specific DNA binding site [nucleotide binding]; other site 754035007570 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 754035007571 Domain of unknown function (DUF955); Region: DUF955; pfam06114 754035007572 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 754035007573 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 754035007574 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035007575 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 754035007576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035007577 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035007578 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 754035007579 Walker A/P-loop; other site 754035007580 ATP binding site [chemical binding]; other site 754035007581 Q-loop/lid; other site 754035007582 ABC transporter signature motif; other site 754035007583 Walker B; other site 754035007584 D-loop; other site 754035007585 H-loop/switch region; other site 754035007586 TOBE domain; Region: TOBE_2; pfam08402 754035007587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007588 dimer interface [polypeptide binding]; other site 754035007589 conserved gate region; other site 754035007590 putative PBP binding loops; other site 754035007591 ABC-ATPase subunit interface; other site 754035007592 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035007593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007594 dimer interface [polypeptide binding]; other site 754035007595 conserved gate region; other site 754035007596 putative PBP binding loops; other site 754035007597 ABC-ATPase subunit interface; other site 754035007598 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 754035007599 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754035007600 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 754035007601 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 754035007602 acyl-activating enzyme (AAE) consensus motif; other site 754035007603 putative AMP binding site [chemical binding]; other site 754035007604 putative active site [active] 754035007605 putative CoA binding site [chemical binding]; other site 754035007606 PAS domain; Region: PAS; smart00091 754035007607 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 754035007608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035007609 putative active site [active] 754035007610 heme pocket [chemical binding]; other site 754035007611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035007612 dimer interface [polypeptide binding]; other site 754035007613 phosphorylation site [posttranslational modification] 754035007614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035007615 ATP binding site [chemical binding]; other site 754035007616 Mg2+ binding site [ion binding]; other site 754035007617 G-X-G motif; other site 754035007618 Phasin protein; Region: Phasin_2; cl11491 754035007619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754035007620 active site 754035007621 Int/Topo IB signature motif; other site 754035007622 DNA binding site [nucleotide binding] 754035007623 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 754035007624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007625 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 754035007626 putative dimerization interface [polypeptide binding]; other site 754035007627 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035007628 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035007629 Walker A/P-loop; other site 754035007630 ATP binding site [chemical binding]; other site 754035007631 Q-loop/lid; other site 754035007632 ABC transporter signature motif; other site 754035007633 Walker B; other site 754035007634 D-loop; other site 754035007635 H-loop/switch region; other site 754035007636 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035007637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035007638 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035007639 TM-ABC transporter signature motif; other site 754035007640 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035007641 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 754035007642 putative ligand binding site [chemical binding]; other site 754035007643 cytosine deaminase; Provisional; Region: PRK05985 754035007644 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 754035007645 active site 754035007646 hypothetical protein; Provisional; Region: PRK06486 754035007647 intersubunit interface [polypeptide binding]; other site 754035007648 active site 754035007649 Zn2+ binding site [ion binding]; other site 754035007650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035007651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035007652 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 754035007653 putative dimerization interface [polypeptide binding]; other site 754035007654 xanthine permease; Region: pbuX; TIGR03173 754035007655 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035007656 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 754035007657 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035007658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035007659 catalytic loop [active] 754035007660 iron binding site [ion binding]; other site 754035007661 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035007662 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035007663 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035007664 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035007665 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 754035007666 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035007667 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 754035007668 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 754035007669 active site 754035007670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 754035007671 active site 754035007672 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 754035007673 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 754035007674 Flavoprotein; Region: Flavoprotein; pfam02441 754035007675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035007676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007677 dimer interface [polypeptide binding]; other site 754035007678 conserved gate region; other site 754035007679 ABC-ATPase subunit interface; other site 754035007680 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035007681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007682 dimer interface [polypeptide binding]; other site 754035007683 conserved gate region; other site 754035007684 putative PBP binding loops; other site 754035007685 ABC-ATPase subunit interface; other site 754035007686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035007687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035007688 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035007689 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035007690 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754035007691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007692 dimer interface [polypeptide binding]; other site 754035007693 conserved gate region; other site 754035007694 putative PBP binding loops; other site 754035007695 ABC-ATPase subunit interface; other site 754035007696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035007697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035007698 dimer interface [polypeptide binding]; other site 754035007699 conserved gate region; other site 754035007700 putative PBP binding loops; other site 754035007701 ABC-ATPase subunit interface; other site 754035007702 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 754035007703 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 754035007704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035007705 nucleotide binding site [chemical binding]; other site 754035007706 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 754035007707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035007708 DNA-binding site [nucleotide binding]; DNA binding site 754035007709 UTRA domain; Region: UTRA; pfam07702 754035007710 hypothetical protein; Provisional; Region: PRK02947 754035007711 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035007712 putative active site [active] 754035007713 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754035007714 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754035007715 catalytic residues [active] 754035007716 catalytic nucleophile [active] 754035007717 Recombinase; Region: Recombinase; pfam07508 754035007718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754035007719 Zn2+ binding site [ion binding]; other site 754035007720 Mg2+ binding site [ion binding]; other site 754035007721 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754035007722 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754035007723 substrate-cofactor binding pocket; other site 754035007724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035007725 catalytic residue [active] 754035007726 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 754035007727 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035007728 ligand binding site [chemical binding]; other site 754035007729 flexible hinge region; other site 754035007730 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035007731 putative switch regulator; other site 754035007732 non-specific DNA interactions [nucleotide binding]; other site 754035007733 DNA binding site [nucleotide binding] 754035007734 sequence specific DNA binding site [nucleotide binding]; other site 754035007735 putative cAMP binding site [chemical binding]; other site 754035007736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035007737 Ligand Binding Site [chemical binding]; other site 754035007738 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 754035007739 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 754035007740 response regulator FixJ; Provisional; Region: fixJ; PRK09390 754035007741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035007742 active site 754035007743 phosphorylation site [posttranslational modification] 754035007744 intermolecular recognition site; other site 754035007745 dimerization interface [polypeptide binding]; other site 754035007746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035007747 DNA binding residues [nucleotide binding] 754035007748 dimerization interface [polypeptide binding]; other site 754035007749 PAS domain; Region: PAS_9; pfam13426 754035007750 PAS domain S-box; Region: sensory_box; TIGR00229 754035007751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035007752 putative active site [active] 754035007753 heme pocket [chemical binding]; other site 754035007754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035007755 dimer interface [polypeptide binding]; other site 754035007756 phosphorylation site [posttranslational modification] 754035007757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035007758 ATP binding site [chemical binding]; other site 754035007759 Mg2+ binding site [ion binding]; other site 754035007760 G-X-G motif; other site 754035007761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035007762 Ligand Binding Site [chemical binding]; other site 754035007763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035007764 Ligand Binding Site [chemical binding]; other site 754035007765 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 754035007766 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 754035007767 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 754035007768 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754035007769 metal-binding site [ion binding] 754035007770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754035007771 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 754035007772 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 754035007773 FixH; Region: FixH; pfam05751 754035007774 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 754035007775 4Fe-4S binding domain; Region: Fer4_5; pfam12801 754035007776 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 754035007777 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 754035007778 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 754035007779 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 754035007780 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 754035007781 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 754035007782 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 754035007783 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 754035007784 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 754035007785 Low-spin heme binding site [chemical binding]; other site 754035007786 Putative water exit pathway; other site 754035007787 Binuclear center (active site) [active] 754035007788 Putative proton exit pathway; other site 754035007789 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 754035007790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035007791 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035007792 ligand binding site [chemical binding]; other site 754035007793 flexible hinge region; other site 754035007794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035007795 putative switch regulator; other site 754035007796 non-specific DNA interactions [nucleotide binding]; other site 754035007797 DNA binding site [nucleotide binding] 754035007798 sequence specific DNA binding site [nucleotide binding]; other site 754035007799 putative cAMP binding site [chemical binding]; other site 754035007800 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 754035007801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035007802 FeS/SAM binding site; other site 754035007803 HemN C-terminal domain; Region: HemN_C; pfam06969 754035007804 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 754035007805 heme-binding site [chemical binding]; other site 754035007806 Uncharacterized conserved protein [Function unknown]; Region: COG1262 754035007807 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 754035007808 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 754035007809 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754035007810 Multicopper oxidase; Region: Cu-oxidase; pfam00394 754035007811 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 754035007812 pseudoazurin; Region: pseudoazurin; TIGR02375 754035007813 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035007814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035007815 ligand binding site [chemical binding]; other site 754035007816 flexible hinge region; other site 754035007817 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035007818 putative switch regulator; other site 754035007819 non-specific DNA interactions [nucleotide binding]; other site 754035007820 DNA binding site [nucleotide binding] 754035007821 sequence specific DNA binding site [nucleotide binding]; other site 754035007822 putative cAMP binding site [chemical binding]; other site 754035007823 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 754035007824 Protein of unknown function (DUF779); Region: DUF779; cl01432 754035007825 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 754035007826 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035007827 NAD(P) binding site [chemical binding]; other site 754035007828 catalytic residues [active] 754035007829 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 754035007830 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035007831 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035007832 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 754035007833 putative NAD(P) binding site [chemical binding]; other site 754035007834 active site 754035007835 putative substrate binding site [chemical binding]; other site 754035007836 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754035007837 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035007838 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035007839 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 754035007840 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 754035007841 Walker A/P-loop; other site 754035007842 ATP binding site [chemical binding]; other site 754035007843 Q-loop/lid; other site 754035007844 ABC transporter signature motif; other site 754035007845 Walker B; other site 754035007846 D-loop; other site 754035007847 H-loop/switch region; other site 754035007848 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 754035007849 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 754035007850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035007851 putative ADP-binding pocket [chemical binding]; other site 754035007852 O-Antigen ligase; Region: Wzy_C; pfam04932 754035007853 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 754035007854 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754035007855 active site 754035007856 dimer interface [polypeptide binding]; other site 754035007857 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754035007858 Ligand Binding Site [chemical binding]; other site 754035007859 Molecular Tunnel; other site 754035007860 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 754035007861 Chain length determinant protein; Region: Wzz; cl15801 754035007862 AAA domain; Region: AAA_31; pfam13614 754035007863 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754035007864 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 754035007865 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754035007866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035007867 active site 754035007868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035007869 DNA binding residues [nucleotide binding] 754035007870 dimerization interface [polypeptide binding]; other site 754035007871 PAS domain S-box; Region: sensory_box; TIGR00229 754035007872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035007873 putative active site [active] 754035007874 heme pocket [chemical binding]; other site 754035007875 PAS domain; Region: PAS_9; pfam13426 754035007876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035007877 HWE histidine kinase; Region: HWE_HK; smart00911 754035007878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035007879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035007880 active site 754035007881 phosphorylation site [posttranslational modification] 754035007882 intermolecular recognition site; other site 754035007883 dimerization interface [polypeptide binding]; other site 754035007884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035007885 DNA binding residues [nucleotide binding] 754035007886 dimerization interface [polypeptide binding]; other site 754035007887 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 754035007888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754035007889 active site 754035007890 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 754035007891 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 754035007892 inhibitor-cofactor binding pocket; inhibition site 754035007893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035007894 catalytic residue [active] 754035007895 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 754035007896 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 754035007897 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 754035007898 NAD binding site [chemical binding]; other site 754035007899 substrate binding site [chemical binding]; other site 754035007900 active site 754035007901 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 754035007902 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 754035007903 SLBB domain; Region: SLBB; pfam10531 754035007904 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 754035007905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035007906 S-adenosylmethionine binding site [chemical binding]; other site 754035007907 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 754035007908 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 754035007909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035007910 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 754035007911 acyl-activating enzyme (AAE) consensus motif; other site 754035007912 putative AMP binding site [chemical binding]; other site 754035007913 putative active site [active] 754035007914 putative CoA binding site [chemical binding]; other site 754035007915 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 754035007916 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754035007917 active site 754035007918 dimer interface [polypeptide binding]; other site 754035007919 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754035007920 Ligand Binding Site [chemical binding]; other site 754035007921 Molecular Tunnel; other site 754035007922 NAD synthetase; Reviewed; Region: nadE; PRK00876 754035007923 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754035007924 Ligand Binding Site [chemical binding]; other site 754035007925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035007926 AMP-binding enzyme; Region: AMP-binding; pfam00501 754035007927 acyl-activating enzyme (AAE) consensus motif; other site 754035007928 AMP binding site [chemical binding]; other site 754035007929 active site 754035007930 CoA binding site [chemical binding]; other site 754035007931 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 754035007932 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 754035007933 nucleophilic elbow; other site 754035007934 catalytic triad; other site 754035007935 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754035007936 GAF domain; Region: GAF; pfam01590 754035007937 GAF domain; Region: GAF; pfam01590 754035007938 GAF domain; Region: GAF_2; pfam13185 754035007939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035007940 PAS fold; Region: PAS_3; pfam08447 754035007941 putative active site [active] 754035007942 heme pocket [chemical binding]; other site 754035007943 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754035007944 GAF domain; Region: GAF; pfam01590 754035007945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035007946 dimer interface [polypeptide binding]; other site 754035007947 phosphorylation site [posttranslational modification] 754035007948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035007949 ATP binding site [chemical binding]; other site 754035007950 Mg2+ binding site [ion binding]; other site 754035007951 G-X-G motif; other site 754035007952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035007953 Response regulator receiver domain; Region: Response_reg; pfam00072 754035007954 active site 754035007955 phosphorylation site [posttranslational modification] 754035007956 intermolecular recognition site; other site 754035007957 dimerization interface [polypeptide binding]; other site 754035007958 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 754035007959 putative catalytic site [active] 754035007960 putative phosphate binding site [ion binding]; other site 754035007961 active site 754035007962 metal binding site A [ion binding]; metal-binding site 754035007963 DNA binding site [nucleotide binding] 754035007964 putative AP binding site [nucleotide binding]; other site 754035007965 putative metal binding site B [ion binding]; other site 754035007966 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 754035007967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035007968 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035007969 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754035007970 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 754035007971 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035007972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035007973 active site 754035007974 phosphorylation site [posttranslational modification] 754035007975 intermolecular recognition site; other site 754035007976 dimerization interface [polypeptide binding]; other site 754035007977 RNA polymerase sigma factor; Provisional; Region: PRK12547 754035007978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035007979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035007980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035007981 ligand binding site [chemical binding]; other site 754035007982 flexible hinge region; other site 754035007983 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035007984 non-specific DNA interactions [nucleotide binding]; other site 754035007985 DNA binding site [nucleotide binding] 754035007986 sequence specific DNA binding site [nucleotide binding]; other site 754035007987 putative cAMP binding site [chemical binding]; other site 754035007988 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 754035007989 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 754035007990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035007991 ATP binding site [chemical binding]; other site 754035007992 putative Mg++ binding site [ion binding]; other site 754035007993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035007994 nucleotide binding region [chemical binding]; other site 754035007995 ATP-binding site [chemical binding]; other site 754035007996 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 754035007997 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 754035007998 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 754035007999 Subunit I/III interface [polypeptide binding]; other site 754035008000 Subunit III/IV interface [polypeptide binding]; other site 754035008001 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 754035008002 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 754035008003 D-pathway; other site 754035008004 Putative ubiquinol binding site [chemical binding]; other site 754035008005 Low-spin heme (heme b) binding site [chemical binding]; other site 754035008006 Putative water exit pathway; other site 754035008007 Binuclear center (heme o3/CuB) [ion binding]; other site 754035008008 K-pathway; other site 754035008009 Putative proton exit pathway; other site 754035008010 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 754035008011 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 754035008012 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 754035008013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035008014 Domain of unknown function (DUF892); Region: DUF892; pfam05974 754035008015 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 754035008016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035008017 UDP-galactopyranose mutase; Region: GLF; pfam03275 754035008018 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 754035008019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035008020 putative homodimer interface [polypeptide binding]; other site 754035008021 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 754035008022 active site 754035008023 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 754035008024 dimanganese center [ion binding]; other site 754035008025 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754035008026 metal binding site [ion binding]; metal-binding site 754035008027 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 754035008028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035008029 Coenzyme A binding pocket [chemical binding]; other site 754035008030 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035008031 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035008032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035008033 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 754035008034 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035008035 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035008036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035008037 ligand binding site [chemical binding]; other site 754035008038 flexible hinge region; other site 754035008039 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 754035008040 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 754035008041 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 754035008042 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035008043 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035008044 ligand binding site [chemical binding]; other site 754035008045 flexible hinge region; other site 754035008046 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 754035008047 HD domain; Region: HD_4; pfam13328 754035008048 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035008049 NMT1/THI5 like; Region: NMT1; pfam09084 754035008050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035008051 membrane-bound complex binding site; other site 754035008052 hinge residues; other site 754035008053 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035008054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008055 dimer interface [polypeptide binding]; other site 754035008056 conserved gate region; other site 754035008057 putative PBP binding loops; other site 754035008058 ABC-ATPase subunit interface; other site 754035008059 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035008060 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035008061 Walker A/P-loop; other site 754035008062 ATP binding site [chemical binding]; other site 754035008063 Q-loop/lid; other site 754035008064 ABC transporter signature motif; other site 754035008065 Walker B; other site 754035008066 D-loop; other site 754035008067 H-loop/switch region; other site 754035008068 choline dehydrogenase; Validated; Region: PRK02106 754035008069 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035008070 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 754035008071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035008072 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754035008073 homotrimer interaction site [polypeptide binding]; other site 754035008074 putative active site [active] 754035008075 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 754035008076 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035008077 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 754035008078 NAD(P) binding site [chemical binding]; other site 754035008079 catalytic residues [active] 754035008080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035008081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008082 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 754035008083 putative substrate binding pocket [chemical binding]; other site 754035008084 dimerization interface [polypeptide binding]; other site 754035008085 acetylornithine deacetylase; Provisional; Region: PRK07522 754035008086 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 754035008087 metal binding site [ion binding]; metal-binding site 754035008088 putative dimer interface [polypeptide binding]; other site 754035008089 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 754035008090 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 754035008091 FMN binding site [chemical binding]; other site 754035008092 active site 754035008093 homodimer interface [polypeptide binding]; other site 754035008094 putative catalytic residue [active] 754035008095 4Fe-4S cluster binding site [ion binding]; other site 754035008096 metabolite-proton symporter; Region: 2A0106; TIGR00883 754035008097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035008098 putative substrate translocation pore; other site 754035008099 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 754035008100 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 754035008101 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 754035008102 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 754035008103 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 754035008104 D-pathway; other site 754035008105 Putative ubiquinol binding site [chemical binding]; other site 754035008106 Low-spin heme (heme b) binding site [chemical binding]; other site 754035008107 Putative water exit pathway; other site 754035008108 Binuclear center (heme o3/CuB) [ion binding]; other site 754035008109 K-pathway; other site 754035008110 Putative proton exit pathway; other site 754035008111 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 754035008112 Subunit I/III interface [polypeptide binding]; other site 754035008113 Subunit III/IV interface [polypeptide binding]; other site 754035008114 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 754035008115 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 754035008116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035008117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035008118 dimer interface [polypeptide binding]; other site 754035008119 phosphorylation site [posttranslational modification] 754035008120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035008121 ATP binding site [chemical binding]; other site 754035008122 Mg2+ binding site [ion binding]; other site 754035008123 G-X-G motif; other site 754035008124 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 754035008125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035008126 active site 754035008127 phosphorylation site [posttranslational modification] 754035008128 intermolecular recognition site; other site 754035008129 dimerization interface [polypeptide binding]; other site 754035008130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035008131 Isochorismatase family; Region: Isochorismatase; pfam00857 754035008132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 754035008133 catalytic triad [active] 754035008134 conserved cis-peptide bond; other site 754035008135 Uncharacterized conserved protein [Function unknown]; Region: COG1415 754035008136 KTSC domain; Region: KTSC; pfam13619 754035008137 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035008138 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 754035008139 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 754035008140 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 754035008141 classical (c) SDRs; Region: SDR_c; cd05233 754035008142 NAD(P) binding site [chemical binding]; other site 754035008143 active site 754035008144 mannonate dehydratase; Provisional; Region: PRK03906 754035008145 mannonate dehydratase; Region: uxuA; TIGR00695 754035008146 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035008147 N-formylglutamate amidohydrolase; Region: FGase; cl01522 754035008148 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 754035008149 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035008150 Isochorismatase family; Region: Isochorismatase; pfam00857 754035008151 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 754035008152 catalytic triad [active] 754035008153 conserved cis-peptide bond; other site 754035008154 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035008155 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035008156 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035008157 putative active site [active] 754035008158 ornithine cyclodeaminase; Validated; Region: PRK07589 754035008159 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035008160 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 754035008161 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 754035008162 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 754035008163 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 754035008164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035008165 NAD(P) binding site [chemical binding]; other site 754035008166 active site 754035008167 Protein of unknown function (DUF768); Region: DUF768; pfam05589 754035008168 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 754035008169 homodimer interface [polypeptide binding]; other site 754035008170 homotetramer interface [polypeptide binding]; other site 754035008171 active site pocket [active] 754035008172 cleavage site 754035008173 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 754035008174 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 754035008175 generic binding surface II; other site 754035008176 generic binding surface I; other site 754035008177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035008178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035008180 dimerization interface [polypeptide binding]; other site 754035008181 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 754035008182 Uncharacterized conserved protein [Function unknown]; Region: COG5403 754035008183 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 754035008184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 754035008185 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 754035008186 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 754035008187 catalytic triad [active] 754035008188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035008189 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 754035008190 active site 754035008191 metal binding site [ion binding]; metal-binding site 754035008192 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 754035008193 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754035008194 phosphate binding site [ion binding]; other site 754035008195 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035008196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035008197 DNA-binding site [nucleotide binding]; DNA binding site 754035008198 FCD domain; Region: FCD; pfam07729 754035008199 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 754035008200 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 754035008201 FAD binding domain; Region: FAD_binding_4; pfam01565 754035008202 FAD binding domain; Region: FAD_binding_4; pfam01565 754035008203 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 754035008204 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 754035008205 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754035008206 Cysteine-rich domain; Region: CCG; pfam02754 754035008207 Cysteine-rich domain; Region: CCG; pfam02754 754035008208 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 754035008209 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 754035008210 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 754035008211 homodimer interface [polypeptide binding]; other site 754035008212 NADP binding site [chemical binding]; other site 754035008213 substrate binding site [chemical binding]; other site 754035008214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035008215 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035008216 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 754035008217 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 754035008218 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 754035008219 dimer interface [polypeptide binding]; other site 754035008220 motif 1; other site 754035008221 motif 2; other site 754035008222 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035008223 active site 754035008224 motif 3; other site 754035008225 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 754035008226 anticodon binding site; other site 754035008227 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 754035008228 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035008229 motif 1; other site 754035008230 dimer interface [polypeptide binding]; other site 754035008231 active site 754035008232 motif 2; other site 754035008233 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035008234 active site 754035008235 motif 3; other site 754035008236 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 754035008237 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 754035008238 AMP-binding domain protein; Validated; Region: PRK08315 754035008239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035008240 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 754035008241 acyl-activating enzyme (AAE) consensus motif; other site 754035008242 acyl-activating enzyme (AAE) consensus motif; other site 754035008243 putative AMP binding site [chemical binding]; other site 754035008244 putative active site [active] 754035008245 putative CoA binding site [chemical binding]; other site 754035008246 Bacterial transcriptional activator domain; Region: BTAD; smart01043 754035008247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035008248 Methyltransferase domain; Region: Methyltransf_11; pfam08241 754035008249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035008250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035008251 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 754035008252 active site 754035008253 tetramer interface [polypeptide binding]; other site 754035008254 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 754035008255 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 754035008256 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 754035008257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035008258 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035008259 substrate binding pocket [chemical binding]; other site 754035008260 membrane-bound complex binding site; other site 754035008261 hinge residues; other site 754035008262 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035008263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008264 dimer interface [polypeptide binding]; other site 754035008265 conserved gate region; other site 754035008266 putative PBP binding loops; other site 754035008267 ABC-ATPase subunit interface; other site 754035008268 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035008269 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035008270 Walker A/P-loop; other site 754035008271 ATP binding site [chemical binding]; other site 754035008272 Q-loop/lid; other site 754035008273 ABC transporter signature motif; other site 754035008274 Walker B; other site 754035008275 D-loop; other site 754035008276 H-loop/switch region; other site 754035008277 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 754035008278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008279 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 754035008280 dimerization interface [polypeptide binding]; other site 754035008281 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 754035008282 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 754035008283 dimer interface [polypeptide binding]; other site 754035008284 active site 754035008285 heme binding site [chemical binding]; other site 754035008286 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 754035008287 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 754035008288 amphipathic channel; other site 754035008289 Asn-Pro-Ala signature motifs; other site 754035008290 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 754035008291 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 754035008292 TspO/MBR family; Region: TspO_MBR; pfam03073 754035008293 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754035008294 CoenzymeA binding site [chemical binding]; other site 754035008295 subunit interaction site [polypeptide binding]; other site 754035008296 PHB binding site; other site 754035008297 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 754035008298 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 754035008299 GMP synthase; Reviewed; Region: guaA; PRK00074 754035008300 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 754035008301 AMP/PPi binding site [chemical binding]; other site 754035008302 candidate oxyanion hole; other site 754035008303 catalytic triad [active] 754035008304 potential glutamine specificity residues [chemical binding]; other site 754035008305 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 754035008306 ATP Binding subdomain [chemical binding]; other site 754035008307 Ligand Binding sites [chemical binding]; other site 754035008308 Dimerization subdomain; other site 754035008309 integrase; Provisional; Region: PRK09692 754035008310 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 754035008311 active site 754035008312 Int/Topo IB signature motif; other site 754035008313 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754035008314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 754035008315 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 754035008316 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 754035008317 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035008318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035008319 DNA binding residues [nucleotide binding] 754035008320 dimerization interface [polypeptide binding]; other site 754035008321 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 754035008322 Autoinducer synthetase; Region: Autoind_synth; cl17404 754035008323 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754035008324 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 754035008325 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 754035008326 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 754035008327 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 754035008328 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754035008329 Sel1-like repeats; Region: SEL1; smart00671 754035008330 Sel1-like repeats; Region: SEL1; smart00671 754035008331 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 754035008332 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 754035008333 Putative transposase; Region: Y2_Tnp; pfam04986 754035008334 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 754035008335 active site 754035008336 catalytic residues [active] 754035008337 DNA binding site [nucleotide binding] 754035008338 Int/Topo IB signature motif; other site 754035008339 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 754035008340 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035008341 NAD binding site [chemical binding]; other site 754035008342 putative substrate binding site 2 [chemical binding]; other site 754035008343 putative substrate binding site 1 [chemical binding]; other site 754035008344 active site 754035008345 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754035008346 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 754035008347 NAD binding site [chemical binding]; other site 754035008348 homodimer interface [polypeptide binding]; other site 754035008349 active site 754035008350 substrate binding site [chemical binding]; other site 754035008351 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754035008352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035008353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035008354 S-adenosylmethionine binding site [chemical binding]; other site 754035008355 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754035008356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754035008357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035008358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035008359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035008360 Walker A/P-loop; other site 754035008361 ATP binding site [chemical binding]; other site 754035008362 Q-loop/lid; other site 754035008363 ABC transporter signature motif; other site 754035008364 Walker B; other site 754035008365 D-loop; other site 754035008366 H-loop/switch region; other site 754035008367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035008368 active site 754035008369 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 754035008370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035008371 FeS/SAM binding site; other site 754035008372 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 754035008373 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 754035008374 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 754035008375 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 754035008376 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 754035008377 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035008378 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 754035008379 ligand binding site [chemical binding]; other site 754035008380 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 754035008381 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 754035008382 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 754035008383 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 754035008384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754035008385 Walker A/P-loop; other site 754035008386 ATP binding site [chemical binding]; other site 754035008387 Q-loop/lid; other site 754035008388 ABC transporter signature motif; other site 754035008389 Walker B; other site 754035008390 D-loop; other site 754035008391 H-loop/switch region; other site 754035008392 ABC-2 type transporter; Region: ABC2_membrane; cl17235 754035008393 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 754035008394 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035008395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008396 dimer interface [polypeptide binding]; other site 754035008397 conserved gate region; other site 754035008398 putative PBP binding loops; other site 754035008399 ABC-ATPase subunit interface; other site 754035008400 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035008401 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035008402 Walker A/P-loop; other site 754035008403 ATP binding site [chemical binding]; other site 754035008404 Q-loop/lid; other site 754035008405 ABC transporter signature motif; other site 754035008406 Walker B; other site 754035008407 D-loop; other site 754035008408 H-loop/switch region; other site 754035008409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035008410 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035008411 substrate binding pocket [chemical binding]; other site 754035008412 membrane-bound complex binding site; other site 754035008413 hinge residues; other site 754035008414 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 754035008415 active site 754035008416 catalytic site [active] 754035008417 Zn binding site [ion binding]; other site 754035008418 tetramer interface [polypeptide binding]; other site 754035008419 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 754035008420 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 754035008421 argininosuccinate lyase; Provisional; Region: PRK00855 754035008422 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 754035008423 active sites [active] 754035008424 tetramer interface [polypeptide binding]; other site 754035008425 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035008426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008427 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035008428 dimerization interface [polypeptide binding]; other site 754035008429 substrate binding pocket [chemical binding]; other site 754035008430 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 754035008431 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 754035008432 Uncharacterized conserved protein [Function unknown]; Region: COG2135 754035008433 RepB plasmid partitioning protein; Region: RepB; pfam07506 754035008434 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754035008435 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754035008436 catalytic residues [active] 754035008437 catalytic nucleophile [active] 754035008438 Recombinase; Region: Recombinase; pfam07508 754035008439 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 754035008440 Uncharacterized conserved protein [Function unknown]; Region: COG5654 754035008441 hypothetical protein; Validated; Region: PRK00029 754035008442 Uncharacterized conserved protein [Function unknown]; Region: COG0397 754035008443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035008444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035008445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035008446 Walker A/P-loop; other site 754035008447 ATP binding site [chemical binding]; other site 754035008448 Q-loop/lid; other site 754035008449 ABC transporter signature motif; other site 754035008450 Walker B; other site 754035008451 D-loop; other site 754035008452 H-loop/switch region; other site 754035008453 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754035008454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035008455 NAD(P) binding site [chemical binding]; other site 754035008456 active site 754035008457 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 754035008458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035008459 UDP-galactopyranose mutase; Region: GLF; pfam03275 754035008460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 754035008461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035008462 putative homodimer interface [polypeptide binding]; other site 754035008463 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754035008464 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 754035008465 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 754035008466 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 754035008467 Subunit I/III interface [polypeptide binding]; other site 754035008468 D-pathway; other site 754035008469 Subunit I/VIIc interface [polypeptide binding]; other site 754035008470 Subunit I/IV interface [polypeptide binding]; other site 754035008471 Subunit I/II interface [polypeptide binding]; other site 754035008472 Low-spin heme (heme a) binding site [chemical binding]; other site 754035008473 Subunit I/VIIa interface [polypeptide binding]; other site 754035008474 Subunit I/VIa interface [polypeptide binding]; other site 754035008475 Dimer interface; other site 754035008476 Putative water exit pathway; other site 754035008477 Binuclear center (heme a3/CuB) [ion binding]; other site 754035008478 K-pathway; other site 754035008479 Subunit I/Vb interface [polypeptide binding]; other site 754035008480 Putative proton exit pathway; other site 754035008481 Subunit I/VIb interface; other site 754035008482 Subunit I/VIc interface [polypeptide binding]; other site 754035008483 Electron transfer pathway; other site 754035008484 Subunit I/VIIIb interface [polypeptide binding]; other site 754035008485 Subunit I/VIIb interface [polypeptide binding]; other site 754035008486 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 754035008487 Iron-sulfur protein interface; other site 754035008488 proximal heme binding site [chemical binding]; other site 754035008489 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 754035008490 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035008491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035008492 TM-ABC transporter signature motif; other site 754035008493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035008494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035008495 TM-ABC transporter signature motif; other site 754035008496 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035008497 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035008498 Walker A/P-loop; other site 754035008499 ATP binding site [chemical binding]; other site 754035008500 Q-loop/lid; other site 754035008501 ABC transporter signature motif; other site 754035008502 Walker B; other site 754035008503 D-loop; other site 754035008504 H-loop/switch region; other site 754035008505 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035008506 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035008507 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 754035008508 putative ligand binding site [chemical binding]; other site 754035008509 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035008510 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035008511 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035008512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035008513 DNA-binding site [nucleotide binding]; DNA binding site 754035008514 FCD domain; Region: FCD; pfam07729 754035008515 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035008516 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035008517 active site pocket [active] 754035008518 short chain dehydrogenase; Provisional; Region: PRK06701 754035008519 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 754035008520 NAD binding site [chemical binding]; other site 754035008521 metal binding site [ion binding]; metal-binding site 754035008522 active site 754035008523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035008524 dimerization interface [polypeptide binding]; other site 754035008525 putative DNA binding site [nucleotide binding]; other site 754035008526 putative Zn2+ binding site [ion binding]; other site 754035008527 Protein of unknown function (DUF768); Region: DUF768; pfam05589 754035008528 Conjugal transfer protein TraD; Region: TraD; pfam06412 754035008529 Conjugal transfer protein TraD; Region: TraD; pfam06412 754035008530 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 754035008531 MobA/MobL family; Region: MobA_MobL; pfam03389 754035008532 AAA domain; Region: AAA_30; pfam13604 754035008533 Family description; Region: UvrD_C_2; pfam13538 754035008534 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 754035008535 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 754035008536 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 754035008537 AsnC family; Region: AsnC_trans_reg; pfam01037 754035008538 Arginase family; Region: Arginase; cd09989 754035008539 active site 754035008540 Mn binding site [ion binding]; other site 754035008541 oligomer interface [polypeptide binding]; other site 754035008542 ornithine cyclodeaminase; Validated; Region: PRK07589 754035008543 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035008544 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 754035008545 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035008546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008547 dimer interface [polypeptide binding]; other site 754035008548 conserved gate region; other site 754035008549 putative PBP binding loops; other site 754035008550 ABC-ATPase subunit interface; other site 754035008551 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 754035008552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008553 dimer interface [polypeptide binding]; other site 754035008554 putative PBP binding loops; other site 754035008555 ABC-ATPase subunit interface; other site 754035008556 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035008557 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035008558 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 754035008559 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 754035008560 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 754035008561 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035008562 MarR family; Region: MarR_2; pfam12802 754035008563 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035008564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035008565 nucleotide binding site [chemical binding]; other site 754035008566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035008567 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 754035008568 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 754035008569 Walker A motif; other site 754035008570 ATP binding site [chemical binding]; other site 754035008571 Walker B motif; other site 754035008572 KaiC; Region: KaiC; pfam06745 754035008573 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 754035008574 Walker A motif; other site 754035008575 ATP binding site [chemical binding]; other site 754035008576 Walker B motif; other site 754035008577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035008578 HWE histidine kinase; Region: HWE_HK; pfam07536 754035008579 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 754035008580 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754035008581 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 754035008582 putative dimer interface [polypeptide binding]; other site 754035008583 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754035008584 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754035008585 putative dimer interface [polypeptide binding]; other site 754035008586 Repression of heat shock gene expression (ROSE) element; Mesau_02801 754035008587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035008588 classical (c) SDRs; Region: SDR_c; cd05233 754035008589 NAD(P) binding site [chemical binding]; other site 754035008590 active site 754035008591 PAS domain S-box; Region: sensory_box; TIGR00229 754035008592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035008593 HWE histidine kinase; Region: HWE_HK; pfam07536 754035008594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035008595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008596 dimer interface [polypeptide binding]; other site 754035008597 conserved gate region; other site 754035008598 putative PBP binding loops; other site 754035008599 ABC-ATPase subunit interface; other site 754035008600 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 754035008601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008602 putative PBP binding loops; other site 754035008603 dimer interface [polypeptide binding]; other site 754035008604 ABC-ATPase subunit interface; other site 754035008605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035008606 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035008607 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035008608 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035008609 Walker A/P-loop; other site 754035008610 ATP binding site [chemical binding]; other site 754035008611 Q-loop/lid; other site 754035008612 ABC transporter signature motif; other site 754035008613 Walker B; other site 754035008614 D-loop; other site 754035008615 H-loop/switch region; other site 754035008616 TOBE domain; Region: TOBE_2; pfam08402 754035008617 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754035008618 O-Antigen ligase; Region: Wzy_C; pfam04932 754035008619 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 754035008620 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754035008621 dimer interface [polypeptide binding]; other site 754035008622 active site 754035008623 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754035008624 Ligand Binding Site [chemical binding]; other site 754035008625 Molecular Tunnel; other site 754035008626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035008627 S-adenosylmethionine binding site [chemical binding]; other site 754035008628 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 754035008629 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754035008630 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754035008631 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 754035008632 putative ADP-binding pocket [chemical binding]; other site 754035008633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035008634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035008635 S-adenosylmethionine binding site [chemical binding]; other site 754035008636 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 754035008637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035008638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035008639 Walker A/P-loop; other site 754035008640 ATP binding site [chemical binding]; other site 754035008641 Q-loop/lid; other site 754035008642 ABC transporter signature motif; other site 754035008643 Walker B; other site 754035008644 D-loop; other site 754035008645 H-loop/switch region; other site 754035008646 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035008647 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 754035008648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035008649 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035008650 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035008651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035008652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035008653 NAD(P) binding site [chemical binding]; other site 754035008654 active site 754035008655 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 754035008656 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 754035008657 Mg++ binding site [ion binding]; other site 754035008658 putative catalytic motif [active] 754035008659 substrate binding site [chemical binding]; other site 754035008660 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754035008661 classical (c) SDRs; Region: SDR_c; cd05233 754035008662 NAD(P) binding site [chemical binding]; other site 754035008663 active site 754035008664 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754035008665 hypothetical protein; Provisional; Region: PRK13559 754035008666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035008667 putative active site [active] 754035008668 heme pocket [chemical binding]; other site 754035008669 HWE histidine kinase; Region: HWE_HK; cl06527 754035008670 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 754035008671 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 754035008672 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035008673 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 754035008674 ligand binding site [chemical binding]; other site 754035008675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 754035008676 Amino acid synthesis; Region: AA_synth; pfam06684 754035008677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754035008678 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 754035008679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754035008680 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 754035008681 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035008682 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 754035008683 NAD(P) binding site [chemical binding]; other site 754035008684 catalytic residues [active] 754035008685 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035008686 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035008687 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 754035008688 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035008689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035008690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035008691 substrate binding pocket [chemical binding]; other site 754035008692 membrane-bound complex binding site; other site 754035008693 hinge residues; other site 754035008694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008695 dimer interface [polypeptide binding]; other site 754035008696 conserved gate region; other site 754035008697 putative PBP binding loops; other site 754035008698 ABC-ATPase subunit interface; other site 754035008699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035008700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035008701 Walker A/P-loop; other site 754035008702 ATP binding site [chemical binding]; other site 754035008703 Q-loop/lid; other site 754035008704 ABC transporter signature motif; other site 754035008705 Walker B; other site 754035008706 D-loop; other site 754035008707 H-loop/switch region; other site 754035008708 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035008709 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035008710 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035008711 [2Fe-2S] cluster binding site [ion binding]; other site 754035008712 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754035008713 hydrophobic ligand binding site; other site 754035008714 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035008715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035008716 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 754035008717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 754035008718 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 754035008719 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 754035008720 homooctamer interface [polypeptide binding]; other site 754035008721 active site 754035008722 Uncharacterized conserved protein [Function unknown]; Region: COG4095 754035008723 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035008724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035008725 ligand binding site [chemical binding]; other site 754035008726 flexible hinge region; other site 754035008727 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035008728 non-specific DNA interactions [nucleotide binding]; other site 754035008729 DNA binding site [nucleotide binding] 754035008730 sequence specific DNA binding site [nucleotide binding]; other site 754035008731 putative cAMP binding site [chemical binding]; other site 754035008732 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 754035008733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035008734 PAS fold; Region: PAS_3; pfam08447 754035008735 putative active site [active] 754035008736 heme pocket [chemical binding]; other site 754035008737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035008738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035008739 metal binding site [ion binding]; metal-binding site 754035008740 active site 754035008741 I-site; other site 754035008742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035008743 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 754035008744 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 754035008745 NADH dehydrogenase subunit D; Validated; Region: PRK06075 754035008746 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 754035008747 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 754035008748 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 754035008749 DNA binding site [nucleotide binding] 754035008750 heterodimer interface [polypeptide binding]; other site 754035008751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035008752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035008753 DNA-binding site [nucleotide binding]; DNA binding site 754035008754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035008755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035008756 homodimer interface [polypeptide binding]; other site 754035008757 catalytic residue [active] 754035008758 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035008759 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035008760 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035008761 Walker A/P-loop; other site 754035008762 ATP binding site [chemical binding]; other site 754035008763 Q-loop/lid; other site 754035008764 ABC transporter signature motif; other site 754035008765 Walker B; other site 754035008766 D-loop; other site 754035008767 H-loop/switch region; other site 754035008768 TOBE domain; Region: TOBE_2; pfam08402 754035008769 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035008770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035008771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008772 dimer interface [polypeptide binding]; other site 754035008773 conserved gate region; other site 754035008774 putative PBP binding loops; other site 754035008775 ABC-ATPase subunit interface; other site 754035008776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035008777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035008778 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035008779 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035008780 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035008781 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035008782 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 754035008783 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 754035008784 active site 754035008785 DNA binding site [nucleotide binding] 754035008786 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 754035008787 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 754035008788 DNA binding site [nucleotide binding] 754035008789 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 754035008790 nucleotide binding site [chemical binding]; other site 754035008791 CHASE4 domain; Region: CHASE4; pfam05228 754035008792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035008793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035008794 metal binding site [ion binding]; metal-binding site 754035008795 active site 754035008796 I-site; other site 754035008797 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035008798 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035008799 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035008800 DNA binding site [nucleotide binding] 754035008801 domain linker motif; other site 754035008802 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754035008803 dimerization interface [polypeptide binding]; other site 754035008804 ligand binding site [chemical binding]; other site 754035008805 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 754035008806 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 754035008807 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754035008808 dimer interface [polypeptide binding]; other site 754035008809 active site 754035008810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035008811 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035008812 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035008813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008814 dimer interface [polypeptide binding]; other site 754035008815 conserved gate region; other site 754035008816 putative PBP binding loops; other site 754035008817 ABC-ATPase subunit interface; other site 754035008818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035008819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008820 dimer interface [polypeptide binding]; other site 754035008821 conserved gate region; other site 754035008822 putative PBP binding loops; other site 754035008823 ABC-ATPase subunit interface; other site 754035008824 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035008825 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035008826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035008827 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754035008828 substrate binding site [chemical binding]; other site 754035008829 ATP binding site [chemical binding]; other site 754035008830 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035008831 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035008832 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035008833 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 754035008834 NAD(P) binding site [chemical binding]; other site 754035008835 catalytic residues [active] 754035008836 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 754035008837 active site 754035008838 catalytic residues [active] 754035008839 metal binding site [ion binding]; metal-binding site 754035008840 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 754035008841 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754035008842 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035008843 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754035008844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 754035008845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035008846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 754035008847 active site 754035008848 metal binding site [ion binding]; metal-binding site 754035008849 amidase; Validated; Region: PRK06565 754035008850 Amidase; Region: Amidase; cl11426 754035008851 Amidase; Region: Amidase; cl11426 754035008852 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 754035008853 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035008854 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 754035008855 active site 754035008856 Bacterial transcriptional activator domain; Region: BTAD; smart01043 754035008857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035008858 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 754035008859 cyclase homology domain; Region: CHD; cd07302 754035008860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 754035008861 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 754035008862 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 754035008863 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 754035008864 active site 754035008865 substrate binding site [chemical binding]; other site 754035008866 FMN binding site [chemical binding]; other site 754035008867 putative catalytic residues [active] 754035008868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035008869 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035008870 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 754035008871 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 754035008872 classical (c) SDRs; Region: SDR_c; cd05233 754035008873 NAD(P) binding site [chemical binding]; other site 754035008874 active site 754035008875 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 754035008876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035008877 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 754035008878 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035008879 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 754035008880 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754035008881 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 754035008882 metal binding site [ion binding]; metal-binding site 754035008883 putative dimer interface [polypeptide binding]; other site 754035008884 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035008885 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 754035008886 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035008887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035008888 catalytic loop [active] 754035008889 iron binding site [ion binding]; other site 754035008890 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035008891 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035008892 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035008893 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035008894 Ubiquitin-like proteins; Region: UBQ; cl00155 754035008895 charged pocket; other site 754035008896 hydrophobic patch; other site 754035008897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035008898 Coenzyme A binding pocket [chemical binding]; other site 754035008899 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 754035008900 Uncharacterized conserved protein [Function unknown]; Region: COG4933 754035008901 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035008902 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 754035008903 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035008904 Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DodA; COG3805 754035008905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035008906 S-adenosylmethionine binding site [chemical binding]; other site 754035008907 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 754035008908 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 754035008909 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 754035008910 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035008911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035008912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035008913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754035008915 dimerization interface [polypeptide binding]; other site 754035008916 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 754035008917 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754035008918 putative active site pocket [active] 754035008919 dimerization interface [polypeptide binding]; other site 754035008920 putative catalytic residue [active] 754035008921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035008922 dimerization interface [polypeptide binding]; other site 754035008923 putative DNA binding site [nucleotide binding]; other site 754035008924 putative Zn2+ binding site [ion binding]; other site 754035008925 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 754035008926 putative hydrophobic ligand binding site [chemical binding]; other site 754035008927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035008928 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 754035008929 Uncharacterized conserved protein [Function unknown]; Region: COG5649 754035008930 Uncharacterized conserved protein [Function unknown]; Region: COG5649 754035008931 Predicted membrane protein [Function unknown]; Region: COG4763 754035008932 Acyltransferase family; Region: Acyl_transf_3; pfam01757 754035008933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 754035008934 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 754035008935 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035008936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008937 dimer interface [polypeptide binding]; other site 754035008938 conserved gate region; other site 754035008939 putative PBP binding loops; other site 754035008940 ABC-ATPase subunit interface; other site 754035008941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035008942 dimer interface [polypeptide binding]; other site 754035008943 conserved gate region; other site 754035008944 putative PBP binding loops; other site 754035008945 ABC-ATPase subunit interface; other site 754035008946 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035008947 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035008948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035008949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035008950 DNA binding site [nucleotide binding] 754035008951 domain linker motif; other site 754035008952 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754035008953 dimerization interface [polypeptide binding]; other site 754035008954 ligand binding site [chemical binding]; other site 754035008955 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 754035008956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035008957 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035008958 Helix-turn-helix domain; Region: HTH_18; pfam12833 754035008959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035008960 Predicted membrane protein [Function unknown]; Region: COG2855 754035008961 Predicted ester cyclase [General function prediction only]; Region: COG5485 754035008962 PAS domain; Region: PAS; smart00091 754035008963 PAS fold; Region: PAS_4; pfam08448 754035008964 putative active site [active] 754035008965 heme pocket [chemical binding]; other site 754035008966 PAS domain S-box; Region: sensory_box; TIGR00229 754035008967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035008968 putative active site [active] 754035008969 heme pocket [chemical binding]; other site 754035008970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035008971 HWE histidine kinase; Region: HWE_HK; pfam07536 754035008972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035008973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035008974 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035008975 putative effector binding pocket; other site 754035008976 putative dimerization interface [polypeptide binding]; other site 754035008977 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035008978 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754035008979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035008980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035008981 active site 754035008982 catalytic tetrad [active] 754035008983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035008984 Coenzyme A binding pocket [chemical binding]; other site 754035008985 Uncharacterized conserved protein [Function unknown]; Region: COG3603 754035008986 Family description; Region: ACT_7; pfam13840 754035008987 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 754035008988 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035008989 NAD binding site [chemical binding]; other site 754035008990 catalytic residues [active] 754035008991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035008992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035008993 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 754035008994 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 754035008995 RES domain; Region: RES; smart00953 754035008996 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 754035008997 Cupin; Region: Cupin_6; pfam12852 754035008998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035008999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035009000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035009001 Ligand Binding Site [chemical binding]; other site 754035009002 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035009003 catalytic core [active] 754035009004 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 754035009005 active site 754035009006 metal binding site [ion binding]; metal-binding site 754035009007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035009008 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 754035009009 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 754035009010 active site 754035009011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035009012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035009013 active site 754035009014 catalytic tetrad [active] 754035009015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009017 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035009018 putative effector binding pocket; other site 754035009019 putative dimerization interface [polypeptide binding]; other site 754035009020 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 754035009021 PAS fold; Region: PAS_4; pfam08448 754035009022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035009023 putative active site [active] 754035009024 heme pocket [chemical binding]; other site 754035009025 PAS fold; Region: PAS_7; pfam12860 754035009026 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035009027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035009028 metal binding site [ion binding]; metal-binding site 754035009029 active site 754035009030 I-site; other site 754035009031 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 754035009032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035009033 salt bridge; other site 754035009034 non-specific DNA binding site [nucleotide binding]; other site 754035009035 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035009036 sequence-specific DNA binding site [nucleotide binding]; other site 754035009037 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035009038 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 754035009039 putative NAD(P) binding site [chemical binding]; other site 754035009040 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 754035009041 RibD C-terminal domain; Region: RibD_C; cl17279 754035009042 Dienelactone hydrolase family; Region: DLH; pfam01738 754035009043 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035009044 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035009045 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035009046 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035009047 Walker A/P-loop; other site 754035009048 ATP binding site [chemical binding]; other site 754035009049 Q-loop/lid; other site 754035009050 ABC transporter signature motif; other site 754035009051 Walker B; other site 754035009052 D-loop; other site 754035009053 H-loop/switch region; other site 754035009054 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035009055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009057 TM-ABC transporter signature motif; other site 754035009058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035009059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035009060 non-specific DNA binding site [nucleotide binding]; other site 754035009061 salt bridge; other site 754035009062 sequence-specific DNA binding site [nucleotide binding]; other site 754035009063 Predicted transcriptional regulator [Transcription]; Region: COG2932 754035009064 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754035009065 Catalytic site [active] 754035009066 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035009067 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 754035009068 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035009069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035009070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035009071 short chain dehydrogenase; Provisional; Region: PRK06179 754035009072 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 754035009073 NADP binding site [chemical binding]; other site 754035009074 active site 754035009075 steroid binding site; other site 754035009076 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035009077 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 754035009078 putative NAD(P) binding site [chemical binding]; other site 754035009079 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035009080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035009081 DNA-binding site [nucleotide binding]; DNA binding site 754035009082 FCD domain; Region: FCD; pfam07729 754035009083 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 754035009084 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035009085 putative ligand binding site [chemical binding]; other site 754035009086 putative NAD binding site [chemical binding]; other site 754035009087 catalytic site [active] 754035009088 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035009089 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 754035009090 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 754035009091 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 754035009092 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 754035009093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035009094 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754035009095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035009096 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 754035009097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035009098 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 754035009099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035009100 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 754035009101 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 754035009102 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 754035009103 active site 754035009104 DNA binding site [nucleotide binding] 754035009105 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 754035009106 DNA binding site [nucleotide binding] 754035009107 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 754035009108 nucleotide binding site [chemical binding]; other site 754035009109 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 754035009110 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 754035009111 putative DNA binding site [nucleotide binding]; other site 754035009112 putative homodimer interface [polypeptide binding]; other site 754035009113 TPR repeat; Region: TPR_11; pfam13414 754035009114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035009115 binding surface 754035009116 TPR motif; other site 754035009117 TPR repeat; Region: TPR_11; pfam13414 754035009118 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 754035009119 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 754035009120 putative catalytic site [active] 754035009121 putative phosphate binding site [ion binding]; other site 754035009122 active site 754035009123 metal binding site A [ion binding]; metal-binding site 754035009124 DNA binding site [nucleotide binding] 754035009125 putative AP binding site [nucleotide binding]; other site 754035009126 putative metal binding site B [ion binding]; other site 754035009127 FOG: WD40 repeat [General function prediction only]; Region: COG2319 754035009128 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 754035009129 structural tetrad; other site 754035009130 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 754035009131 putative S-transferase; Provisional; Region: PRK11752 754035009132 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 754035009133 C-terminal domain interface [polypeptide binding]; other site 754035009134 GSH binding site (G-site) [chemical binding]; other site 754035009135 dimer interface [polypeptide binding]; other site 754035009136 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 754035009137 dimer interface [polypeptide binding]; other site 754035009138 N-terminal domain interface [polypeptide binding]; other site 754035009139 active site 754035009140 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 754035009141 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035009142 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035009143 protein binding site [polypeptide binding]; other site 754035009144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754035009147 dimerization interface [polypeptide binding]; other site 754035009148 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 754035009149 short chain dehydrogenase; Provisional; Region: PRK07041 754035009150 putative NAD(P) binding site [chemical binding]; other site 754035009151 homodimer interface [polypeptide binding]; other site 754035009152 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035009153 MarR family; Region: MarR_2; cl17246 754035009154 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035009155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 754035009156 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 754035009157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009159 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035009160 putative effector binding pocket; other site 754035009161 dimerization interface [polypeptide binding]; other site 754035009162 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 754035009163 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754035009164 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754035009165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035009166 NAD(P) binding site [chemical binding]; other site 754035009167 active site 754035009168 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035009169 Predicted transcriptional regulator [Transcription]; Region: COG1959 754035009170 Transcriptional regulator; Region: Rrf2; pfam02082 754035009171 EthD domain; Region: EthD; cl17553 754035009172 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754035009173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035009174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009175 Walker A/P-loop; other site 754035009176 ATP binding site [chemical binding]; other site 754035009177 Q-loop/lid; other site 754035009178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035009179 ABC transporter signature motif; other site 754035009180 Walker B; other site 754035009181 D-loop; other site 754035009182 ABC transporter; Region: ABC_tran_2; pfam12848 754035009183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035009184 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 754035009185 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035009186 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035009187 conserved cys residue [active] 754035009188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009190 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 754035009191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035009192 inhibitor-cofactor binding pocket; inhibition site 754035009193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035009194 catalytic residue [active] 754035009195 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035009196 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035009197 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035009198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009199 Walker A/P-loop; other site 754035009200 ATP binding site [chemical binding]; other site 754035009201 Q-loop/lid; other site 754035009202 ABC transporter signature motif; other site 754035009203 Walker B; other site 754035009204 D-loop; other site 754035009205 H-loop/switch region; other site 754035009206 TOBE domain; Region: TOBE_2; pfam08402 754035009207 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035009208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035009209 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035009210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009211 dimer interface [polypeptide binding]; other site 754035009212 conserved gate region; other site 754035009213 putative PBP binding loops; other site 754035009214 ABC-ATPase subunit interface; other site 754035009215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009216 dimer interface [polypeptide binding]; other site 754035009217 conserved gate region; other site 754035009218 putative PBP binding loops; other site 754035009219 ABC-ATPase subunit interface; other site 754035009220 heat shock protein 90; Provisional; Region: PRK05218 754035009221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035009222 ATP binding site [chemical binding]; other site 754035009223 Mg2+ binding site [ion binding]; other site 754035009224 G-X-G motif; other site 754035009225 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 754035009226 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 754035009227 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 754035009228 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 754035009229 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 754035009230 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035009231 EamA-like transporter family; Region: EamA; pfam00892 754035009232 EamA-like transporter family; Region: EamA; pfam00892 754035009233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009235 LysR substrate binding domain; Region: LysR_substrate; pfam03466 754035009236 dimerization interface [polypeptide binding]; other site 754035009237 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 754035009238 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 754035009239 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 754035009240 active site 754035009241 acyl-activating enzyme (AAE) consensus motif; other site 754035009242 putative CoA binding site [chemical binding]; other site 754035009243 AMP binding site [chemical binding]; other site 754035009244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 754035009247 putative effector binding pocket; other site 754035009248 putative dimerization interface [polypeptide binding]; other site 754035009249 short chain dehydrogenase; Provisional; Region: PRK12937 754035009250 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 754035009251 NADP binding site [chemical binding]; other site 754035009252 homodimer interface [polypeptide binding]; other site 754035009253 active site 754035009254 substrate binding site [chemical binding]; other site 754035009255 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 754035009256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035009257 dimerization interface [polypeptide binding]; other site 754035009258 putative DNA binding site [nucleotide binding]; other site 754035009259 putative Zn2+ binding site [ion binding]; other site 754035009260 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 754035009261 amphipathic channel; other site 754035009262 Asn-Pro-Ala signature motifs; other site 754035009263 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 754035009264 ArsC family; Region: ArsC; pfam03960 754035009265 catalytic residues [active] 754035009266 short chain dehydrogenase; Provisional; Region: PRK06179 754035009267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035009268 NAD(P) binding site [chemical binding]; other site 754035009269 active site 754035009270 YCII-related domain; Region: YCII; cl00999 754035009271 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035009272 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035009273 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035009274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009275 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035009276 dimerization interface [polypeptide binding]; other site 754035009277 substrate binding pocket [chemical binding]; other site 754035009278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035009279 NmrA-like family; Region: NmrA; pfam05368 754035009280 NAD(P) binding site [chemical binding]; other site 754035009281 active site 754035009282 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 754035009283 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035009284 FeS/SAM binding site; other site 754035009285 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 754035009286 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 754035009287 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 754035009288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035009289 Coenzyme A binding pocket [chemical binding]; other site 754035009290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035009291 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 754035009292 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 754035009293 acyl-activating enzyme (AAE) consensus motif; other site 754035009294 AMP binding site [chemical binding]; other site 754035009295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 754035009296 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 754035009297 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 754035009298 putative trimer interface [polypeptide binding]; other site 754035009299 putative CoA binding site [chemical binding]; other site 754035009300 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 754035009301 trimer interface [polypeptide binding]; other site 754035009302 active site 754035009303 substrate binding site [chemical binding]; other site 754035009304 CoA binding site [chemical binding]; other site 754035009305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035009306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035009307 TPR motif; other site 754035009308 TPR repeat; Region: TPR_11; pfam13414 754035009309 binding surface 754035009310 Predicted membrane protein [Function unknown]; Region: COG2259 754035009311 BA14K-like protein; Region: BA14K; pfam07886 754035009312 BA14K-like protein; Region: BA14K; pfam07886 754035009313 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 754035009314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009315 dimerization interface [polypeptide binding]; other site 754035009316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009317 dimerization interface [polypeptide binding]; other site 754035009318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009319 dimerization interface [polypeptide binding]; other site 754035009320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009321 dimerization interface [polypeptide binding]; other site 754035009322 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 754035009323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009324 dimerization interface [polypeptide binding]; other site 754035009325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009326 dimerization interface [polypeptide binding]; other site 754035009327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009328 dimerization interface [polypeptide binding]; other site 754035009329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009330 dimerization interface [polypeptide binding]; other site 754035009331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035009332 dimerization interface [polypeptide binding]; other site 754035009333 GAF domain; Region: GAF_2; pfam13185 754035009334 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 754035009335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035009336 ATP binding site [chemical binding]; other site 754035009337 Mg2+ binding site [ion binding]; other site 754035009338 G-X-G motif; other site 754035009339 Response regulator receiver domain; Region: Response_reg; pfam00072 754035009340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035009341 active site 754035009342 phosphorylation site [posttranslational modification] 754035009343 intermolecular recognition site; other site 754035009344 dimerization interface [polypeptide binding]; other site 754035009345 Response regulator receiver domain; Region: Response_reg; pfam00072 754035009346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035009347 active site 754035009348 phosphorylation site [posttranslational modification] 754035009349 intermolecular recognition site; other site 754035009350 dimerization interface [polypeptide binding]; other site 754035009351 Response regulator receiver domain; Region: Response_reg; pfam00072 754035009352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035009353 active site 754035009354 phosphorylation site [posttranslational modification] 754035009355 intermolecular recognition site; other site 754035009356 dimerization interface [polypeptide binding]; other site 754035009357 PAS fold; Region: PAS_3; pfam08447 754035009358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035009359 dimer interface [polypeptide binding]; other site 754035009360 phosphorylation site [posttranslational modification] 754035009361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035009362 ATP binding site [chemical binding]; other site 754035009363 Mg2+ binding site [ion binding]; other site 754035009364 G-X-G motif; other site 754035009365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035009366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035009367 active site 754035009368 phosphorylation site [posttranslational modification] 754035009369 intermolecular recognition site; other site 754035009370 dimerization interface [polypeptide binding]; other site 754035009371 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 754035009372 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 754035009373 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 754035009374 Switch I; other site 754035009375 Switch II; other site 754035009376 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 754035009377 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 754035009378 HAMP domain; Region: HAMP; pfam00672 754035009379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035009380 dimer interface [polypeptide binding]; other site 754035009381 phosphorylation site [posttranslational modification] 754035009382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035009383 ATP binding site [chemical binding]; other site 754035009384 G-X-G motif; other site 754035009385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035009386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035009387 active site 754035009388 phosphorylation site [posttranslational modification] 754035009389 intermolecular recognition site; other site 754035009390 dimerization interface [polypeptide binding]; other site 754035009391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035009392 DNA binding site [nucleotide binding] 754035009393 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 754035009394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035009395 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035009396 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 754035009397 Protein export membrane protein; Region: SecD_SecF; cl14618 754035009398 Protein export membrane protein; Region: SecD_SecF; cl14618 754035009399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035009400 PAS domain; Region: PAS_9; pfam13426 754035009401 putative active site [active] 754035009402 heme pocket [chemical binding]; other site 754035009403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035009404 Histidine kinase; Region: HisKA_2; pfam07568 754035009405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035009406 ATP binding site [chemical binding]; other site 754035009407 Mg2+ binding site [ion binding]; other site 754035009408 G-X-G motif; other site 754035009409 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 754035009410 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754035009411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035009412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009413 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 754035009414 DNA binding residues [nucleotide binding] 754035009415 dimerization interface [polypeptide binding]; other site 754035009416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009417 LysR family transcriptional regulator; Provisional; Region: PRK14997 754035009418 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035009419 putative effector binding pocket; other site 754035009420 dimerization interface [polypeptide binding]; other site 754035009421 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 754035009422 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035009423 putative NAD(P) binding site [chemical binding]; other site 754035009424 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035009425 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035009426 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035009427 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035009428 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 754035009429 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035009430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035009431 catalytic loop [active] 754035009432 iron binding site [ion binding]; other site 754035009433 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035009434 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035009435 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035009436 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035009437 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035009438 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 754035009439 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035009440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035009441 catalytic loop [active] 754035009442 iron binding site [ion binding]; other site 754035009443 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035009444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035009445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035009446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009447 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 754035009448 putative substrate binding pocket [chemical binding]; other site 754035009449 putative dimerization interface [polypeptide binding]; other site 754035009450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035009451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035009452 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 754035009453 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 754035009454 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 754035009455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035009456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035009457 active site 754035009458 catalytic tetrad [active] 754035009459 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035009460 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754035009461 C-terminal domain interface [polypeptide binding]; other site 754035009462 GSH binding site (G-site) [chemical binding]; other site 754035009463 dimer interface [polypeptide binding]; other site 754035009464 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035009465 N-terminal domain interface [polypeptide binding]; other site 754035009466 HerA helicase [Replication, recombination, and repair]; Region: COG0433 754035009467 Usg-like family; Region: Usg; cl11567 754035009468 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754035009469 oligomerisation interface [polypeptide binding]; other site 754035009470 mobile loop; other site 754035009471 roof hairpin; other site 754035009472 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754035009473 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754035009474 ring oligomerisation interface [polypeptide binding]; other site 754035009475 ATP/Mg binding site [chemical binding]; other site 754035009476 stacking interactions; other site 754035009477 hinge regions; other site 754035009478 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035009479 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 754035009480 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009481 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009482 TM-ABC transporter signature motif; other site 754035009483 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009484 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009485 TM-ABC transporter signature motif; other site 754035009486 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035009487 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035009488 Walker A/P-loop; other site 754035009489 ATP binding site [chemical binding]; other site 754035009490 Q-loop/lid; other site 754035009491 ABC transporter signature motif; other site 754035009492 Walker B; other site 754035009493 D-loop; other site 754035009494 H-loop/switch region; other site 754035009495 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035009496 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 754035009497 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009498 putative ligand binding site [chemical binding]; other site 754035009499 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035009500 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035009501 DNA interaction; other site 754035009502 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 754035009503 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754035009504 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754035009505 short chain dehydrogenase; Provisional; Region: PRK06198 754035009506 classical (c) SDRs; Region: SDR_c; cd05233 754035009507 NAD(P) binding site [chemical binding]; other site 754035009508 active site 754035009509 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035009510 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035009511 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035009512 putative active site [active] 754035009513 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035009514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035009515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035009516 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 754035009517 nudix motif; other site 754035009518 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 754035009519 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 754035009520 Uncharacterized conserved protein [Function unknown]; Region: COG3339 754035009521 DNA polymerase IV; Validated; Region: PRK03858 754035009522 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754035009523 active site 754035009524 DNA binding site [nucleotide binding] 754035009525 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035009526 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035009527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035009528 NmrA-like family; Region: NmrA; pfam05368 754035009529 NAD(P) binding site [chemical binding]; other site 754035009530 active site 754035009531 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035009532 RibD C-terminal domain; Region: RibD_C; pfam01872 754035009533 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754035009534 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 754035009535 NADP binding site [chemical binding]; other site 754035009536 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 754035009537 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 754035009538 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035009539 RibD C-terminal domain; Region: RibD_C; cl17279 754035009540 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 754035009541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035009542 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035009543 DNA binding residues [nucleotide binding] 754035009544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035009545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035009546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035009547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035009548 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754035009549 putative effector binding pocket; other site 754035009550 dimerization interface [polypeptide binding]; other site 754035009551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 754035009552 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 754035009553 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754035009554 DNA binding site [nucleotide binding] 754035009555 active site 754035009556 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 754035009557 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 754035009558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009559 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754035009560 DNA binding site [nucleotide binding] 754035009561 active site 754035009562 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035009563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035009564 dimerization interface [polypeptide binding]; other site 754035009565 putative DNA binding site [nucleotide binding]; other site 754035009566 putative Zn2+ binding site [ion binding]; other site 754035009567 Uncharacterized conserved protein [Function unknown]; Region: COG5470 754035009568 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 754035009569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035009570 PAS fold; Region: PAS_3; pfam08447 754035009571 putative active site [active] 754035009572 heme pocket [chemical binding]; other site 754035009573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035009574 PAS fold; Region: PAS_3; pfam08447 754035009575 putative active site [active] 754035009576 heme pocket [chemical binding]; other site 754035009577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035009578 metal binding site [ion binding]; metal-binding site 754035009579 active site 754035009580 I-site; other site 754035009581 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035009582 Uncharacterized conserved protein [Function unknown]; Region: COG3246 754035009583 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 754035009584 Fic family protein [Function unknown]; Region: COG3177 754035009585 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 754035009586 Fic/DOC family; Region: Fic; pfam02661 754035009587 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035009588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035009589 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035009590 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 754035009591 peptide binding site [polypeptide binding]; other site 754035009592 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035009593 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035009594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035009595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035009596 non-specific DNA binding site [nucleotide binding]; other site 754035009597 salt bridge; other site 754035009598 sequence-specific DNA binding site [nucleotide binding]; other site 754035009599 Cupin domain; Region: Cupin_2; pfam07883 754035009600 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 754035009601 putative NAD(P) binding site [chemical binding]; other site 754035009602 putative active site [active] 754035009603 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 754035009604 GIY-YIG motif/motif A; other site 754035009605 putative active site [active] 754035009606 putative metal binding site [ion binding]; other site 754035009607 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 754035009608 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 754035009609 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 754035009610 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 754035009611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035009612 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 754035009613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035009614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035009615 homodimer interface [polypeptide binding]; other site 754035009616 catalytic residue [active] 754035009617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 754035009618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035009619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035009620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009621 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035009622 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035009623 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 754035009624 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754035009625 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035009626 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754035009627 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754035009628 nickel responsive regulator; Provisional; Region: PRK02967 754035009629 PAS domain S-box; Region: sensory_box; TIGR00229 754035009630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035009631 putative active site [active] 754035009632 heme pocket [chemical binding]; other site 754035009633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035009634 HWE histidine kinase; Region: HWE_HK; pfam07536 754035009635 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035009636 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 754035009637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035009638 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035009639 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035009640 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035009641 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 754035009642 Predicted membrane protein [Function unknown]; Region: COG2259 754035009643 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 754035009644 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 754035009645 methionine sulfoxide reductase A; Provisional; Region: PRK14054 754035009646 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 754035009647 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 754035009648 active site 754035009649 cosubstrate binding site; other site 754035009650 substrate binding site [chemical binding]; other site 754035009651 catalytic site [active] 754035009652 YKOF-related Family; Region: Ykof; pfam07615 754035009653 YKOF-related Family; Region: Ykof; pfam07615 754035009654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035009655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009656 putative PBP binding loops; other site 754035009657 ABC-ATPase subunit interface; other site 754035009658 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035009659 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035009660 Walker A/P-loop; other site 754035009661 ATP binding site [chemical binding]; other site 754035009662 Q-loop/lid; other site 754035009663 ABC transporter signature motif; other site 754035009664 Walker B; other site 754035009665 D-loop; other site 754035009666 H-loop/switch region; other site 754035009667 NMT1/THI5 like; Region: NMT1; pfam09084 754035009668 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035009669 Protein of unknown function (DUF521); Region: DUF521; pfam04412 754035009670 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 754035009671 substrate binding site [chemical binding]; other site 754035009672 ligand binding site [chemical binding]; other site 754035009673 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 754035009674 substrate binding site [chemical binding]; other site 754035009675 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 754035009676 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035009677 putative catalytic residue [active] 754035009678 FAD binding domain; Region: FAD_binding_2; pfam00890 754035009679 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754035009680 Ferredoxin [Energy production and conversion]; Region: COG1146 754035009681 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 754035009682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035009683 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035009684 Walker A/P-loop; other site 754035009685 ATP binding site [chemical binding]; other site 754035009686 Q-loop/lid; other site 754035009687 ABC transporter signature motif; other site 754035009688 Walker B; other site 754035009689 D-loop; other site 754035009690 H-loop/switch region; other site 754035009691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035009692 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 754035009693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009694 dimer interface [polypeptide binding]; other site 754035009695 conserved gate region; other site 754035009696 putative PBP binding loops; other site 754035009697 ABC-ATPase subunit interface; other site 754035009698 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 754035009699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035009700 substrate binding pocket [chemical binding]; other site 754035009701 membrane-bound complex binding site; other site 754035009702 hinge residues; other site 754035009703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035009704 DNA binding site [nucleotide binding] 754035009705 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 754035009706 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009707 putative ligand binding site [chemical binding]; other site 754035009708 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035009709 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035009710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035009711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009712 putative PBP binding loops; other site 754035009713 dimer interface [polypeptide binding]; other site 754035009714 ABC-ATPase subunit interface; other site 754035009715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009716 conserved gate region; other site 754035009717 putative PBP binding loops; other site 754035009718 ABC-ATPase subunit interface; other site 754035009719 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035009720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009721 Walker A/P-loop; other site 754035009722 ATP binding site [chemical binding]; other site 754035009723 Q-loop/lid; other site 754035009724 ABC transporter signature motif; other site 754035009725 Walker B; other site 754035009726 D-loop; other site 754035009727 H-loop/switch region; other site 754035009728 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035009729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009730 Walker A/P-loop; other site 754035009731 ATP binding site [chemical binding]; other site 754035009732 Q-loop/lid; other site 754035009733 ABC transporter signature motif; other site 754035009734 Walker B; other site 754035009735 D-loop; other site 754035009736 H-loop/switch region; other site 754035009737 TOBE domain; Region: TOBE_2; pfam08402 754035009738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035009739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035009740 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035009741 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035009742 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754035009743 DNA interaction; other site 754035009744 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035009745 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009747 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009748 TM-ABC transporter signature motif; other site 754035009749 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035009750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009751 Walker A/P-loop; other site 754035009752 ATP binding site [chemical binding]; other site 754035009753 Q-loop/lid; other site 754035009754 ABC transporter signature motif; other site 754035009755 Walker B; other site 754035009756 D-loop; other site 754035009757 H-loop/switch region; other site 754035009758 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 754035009759 active site 754035009760 catalytic residues [active] 754035009761 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 754035009762 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 754035009763 putative di-iron ligands [ion binding]; other site 754035009764 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 754035009765 [2Fe-2S] cluster binding site [ion binding]; other site 754035009766 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 754035009767 oligomerization interface [polypeptide binding]; other site 754035009768 active site 754035009769 metal binding site [ion binding]; metal-binding site 754035009770 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 754035009771 active sites [active] 754035009772 tetramer interface [polypeptide binding]; other site 754035009773 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 754035009774 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035009775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035009776 putative transporter; Provisional; Region: PRK10504 754035009777 putative substrate translocation pore; other site 754035009778 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009779 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009780 TM-ABC transporter signature motif; other site 754035009781 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 754035009782 ligand binding site [chemical binding]; other site 754035009783 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009784 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009785 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009786 TM-ABC transporter signature motif; other site 754035009787 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 754035009788 Strictosidine synthase; Region: Str_synth; pfam03088 754035009789 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 754035009790 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035009791 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035009792 Walker A/P-loop; other site 754035009793 ATP binding site [chemical binding]; other site 754035009794 Q-loop/lid; other site 754035009795 ABC transporter signature motif; other site 754035009796 Walker B; other site 754035009797 D-loop; other site 754035009798 H-loop/switch region; other site 754035009799 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035009800 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754035009801 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 754035009802 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 754035009803 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754035009804 active site 754035009805 metal binding site [ion binding]; metal-binding site 754035009806 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035009807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035009808 Walker A/P-loop; other site 754035009809 ATP binding site [chemical binding]; other site 754035009810 Q-loop/lid; other site 754035009811 ABC transporter signature motif; other site 754035009812 Walker B; other site 754035009813 D-loop; other site 754035009814 H-loop/switch region; other site 754035009815 TOBE domain; Region: TOBE_2; pfam08402 754035009816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009817 dimer interface [polypeptide binding]; other site 754035009818 conserved gate region; other site 754035009819 putative PBP binding loops; other site 754035009820 ABC-ATPase subunit interface; other site 754035009821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035009822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009823 dimer interface [polypeptide binding]; other site 754035009824 conserved gate region; other site 754035009825 putative PBP binding loops; other site 754035009826 ABC-ATPase subunit interface; other site 754035009827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035009828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035009829 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 754035009830 Amidohydrolase; Region: Amidohydro_2; pfam04909 754035009831 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 754035009832 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 754035009833 metal ion-dependent adhesion site (MIDAS); other site 754035009834 MoxR-like ATPases [General function prediction only]; Region: COG0714 754035009835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035009836 Walker A motif; other site 754035009837 ATP binding site [chemical binding]; other site 754035009838 Walker B motif; other site 754035009839 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035009840 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035009841 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035009842 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035009843 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035009844 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035009845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035009846 catalytic loop [active] 754035009847 iron binding site [ion binding]; other site 754035009848 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035009849 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035009850 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 754035009851 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 754035009852 putative hydrophobic ligand binding site [chemical binding]; other site 754035009853 protein interface [polypeptide binding]; other site 754035009854 gate; other site 754035009855 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754035009856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035009857 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009859 TM-ABC transporter signature motif; other site 754035009860 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035009861 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035009862 Walker A/P-loop; other site 754035009863 ATP binding site [chemical binding]; other site 754035009864 Q-loop/lid; other site 754035009865 ABC transporter signature motif; other site 754035009866 Walker B; other site 754035009867 D-loop; other site 754035009868 H-loop/switch region; other site 754035009869 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 754035009870 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009871 ligand binding site [chemical binding]; other site 754035009872 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035009873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035009874 DNA-binding site [nucleotide binding]; DNA binding site 754035009875 FCD domain; Region: FCD; pfam07729 754035009876 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 754035009877 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035009878 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035009879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035009880 NAD(P) binding site [chemical binding]; other site 754035009881 active site 754035009882 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035009883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035009884 DNA-binding site [nucleotide binding]; DNA binding site 754035009885 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754035009886 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 754035009887 putative hydrophobic ligand binding site [chemical binding]; other site 754035009888 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 754035009889 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 754035009890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035009891 putative substrate translocation pore; other site 754035009892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035009893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035009894 DNA binding site [nucleotide binding] 754035009895 domain linker motif; other site 754035009896 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 754035009897 putative ligand binding site [chemical binding]; other site 754035009898 putative dimerization interface [polypeptide binding]; other site 754035009899 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 754035009900 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035009901 putative ligand binding site [chemical binding]; other site 754035009902 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035009903 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035009904 Walker A/P-loop; other site 754035009905 ATP binding site [chemical binding]; other site 754035009906 Q-loop/lid; other site 754035009907 ABC transporter signature motif; other site 754035009908 Walker B; other site 754035009909 D-loop; other site 754035009910 H-loop/switch region; other site 754035009911 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035009912 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009914 TM-ABC transporter signature motif; other site 754035009915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035009916 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035009917 TM-ABC transporter signature motif; other site 754035009918 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 754035009919 AAA domain; Region: AAA_33; pfam13671 754035009920 ATP-binding site [chemical binding]; other site 754035009921 Gluconate-6-phosphate binding site [chemical binding]; other site 754035009922 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 754035009923 putative acyl-acceptor binding pocket; other site 754035009924 Predicted transcriptional regulator [Transcription]; Region: COG1959 754035009925 Transcriptional regulator; Region: Rrf2; pfam02082 754035009926 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035009927 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754035009928 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 754035009929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 754035009930 Coenzyme A binding pocket [chemical binding]; other site 754035009931 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 754035009932 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 754035009933 Walker A/P-loop; other site 754035009934 ATP binding site [chemical binding]; other site 754035009935 Q-loop/lid; other site 754035009936 ABC transporter signature motif; other site 754035009937 Walker B; other site 754035009938 D-loop; other site 754035009939 H-loop/switch region; other site 754035009940 TOBE-like domain; Region: TOBE_3; pfam12857 754035009941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009942 dimer interface [polypeptide binding]; other site 754035009943 conserved gate region; other site 754035009944 putative PBP binding loops; other site 754035009945 ABC-ATPase subunit interface; other site 754035009946 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754035009947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009948 dimer interface [polypeptide binding]; other site 754035009949 conserved gate region; other site 754035009950 putative PBP binding loops; other site 754035009951 ABC-ATPase subunit interface; other site 754035009952 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 754035009953 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754035009954 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 754035009955 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 754035009956 Transglycosylase; Region: Transgly; pfam00912 754035009957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754035009958 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 754035009959 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 754035009960 putative binding site; other site 754035009961 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 754035009962 MG2 domain; Region: A2M_N; pfam01835 754035009963 Alpha-2-macroglobulin family; Region: A2M; pfam00207 754035009964 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 754035009965 surface patch; other site 754035009966 thioester region; other site 754035009967 specificity defining residues; other site 754035009968 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 754035009969 Surface antigen; Region: Bac_surface_Ag; pfam01103 754035009970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 754035009971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 754035009972 Family of unknown function (DUF490); Region: DUF490; pfam04357 754035009973 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035009974 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035009975 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035009976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009977 dimer interface [polypeptide binding]; other site 754035009978 conserved gate region; other site 754035009979 putative PBP binding loops; other site 754035009980 ABC-ATPase subunit interface; other site 754035009981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035009982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035009983 dimer interface [polypeptide binding]; other site 754035009984 conserved gate region; other site 754035009985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035009986 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 754035009987 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035009988 Walker A/P-loop; other site 754035009989 ATP binding site [chemical binding]; other site 754035009990 Q-loop/lid; other site 754035009991 ABC transporter signature motif; other site 754035009992 Walker B; other site 754035009993 D-loop; other site 754035009994 H-loop/switch region; other site 754035009995 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035009996 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035009997 Walker A/P-loop; other site 754035009998 ATP binding site [chemical binding]; other site 754035009999 Q-loop/lid; other site 754035010000 ABC transporter signature motif; other site 754035010001 Walker B; other site 754035010002 D-loop; other site 754035010003 H-loop/switch region; other site 754035010004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035010005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035010006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035010007 catalytic residue [active] 754035010008 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 754035010009 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035010010 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010011 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035010012 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 754035010013 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010014 Predicted membrane protein [Function unknown]; Region: COG2259 754035010015 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 754035010016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035010017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035010018 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 754035010019 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 754035010020 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754035010021 putative active site pocket [active] 754035010022 dimerization interface [polypeptide binding]; other site 754035010023 putative catalytic residue [active] 754035010024 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 754035010025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035010026 S-adenosylmethionine binding site [chemical binding]; other site 754035010027 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 754035010028 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 754035010029 homodimer interface [polypeptide binding]; other site 754035010030 active site 754035010031 FMN binding site [chemical binding]; other site 754035010032 substrate binding site [chemical binding]; other site 754035010033 4Fe-4S binding domain; Region: Fer4_6; pfam12837 754035010034 4Fe-4S binding domain; Region: Fer4; pfam00037 754035010035 Predicted transcriptional regulator [Transcription]; Region: COG1959 754035010036 Transcriptional regulator; Region: Rrf2; pfam02082 754035010037 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754035010038 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 754035010039 Predicted membrane protein [Function unknown]; Region: COG2259 754035010040 short chain dehydrogenase; Provisional; Region: PRK07041 754035010041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035010042 NAD(P) binding site [chemical binding]; other site 754035010043 active site 754035010044 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 754035010045 short chain dehydrogenase; Provisional; Region: PRK06197 754035010046 putative NAD(P) binding site [chemical binding]; other site 754035010047 active site 754035010048 Helix-turn-helix domain; Region: HTH_31; pfam13560 754035010049 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 754035010050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035010051 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 754035010052 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 754035010053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035010054 inhibitor-cofactor binding pocket; inhibition site 754035010055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035010056 catalytic residue [active] 754035010057 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 754035010058 putative active site [active] 754035010059 allantoate amidohydrolase; Reviewed; Region: PRK12893 754035010060 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 754035010061 active site 754035010062 metal binding site [ion binding]; metal-binding site 754035010063 dimer interface [polypeptide binding]; other site 754035010064 phenylhydantoinase; Validated; Region: PRK08323 754035010065 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 754035010066 tetramer interface [polypeptide binding]; other site 754035010067 active site 754035010068 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 754035010069 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035010070 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035010071 Walker A/P-loop; other site 754035010072 ATP binding site [chemical binding]; other site 754035010073 Q-loop/lid; other site 754035010074 ABC transporter signature motif; other site 754035010075 Walker B; other site 754035010076 D-loop; other site 754035010077 H-loop/switch region; other site 754035010078 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035010079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010080 dimer interface [polypeptide binding]; other site 754035010081 conserved gate region; other site 754035010082 putative PBP binding loops; other site 754035010083 ABC-ATPase subunit interface; other site 754035010084 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035010085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010086 dimer interface [polypeptide binding]; other site 754035010087 conserved gate region; other site 754035010088 putative PBP binding loops; other site 754035010089 ABC-ATPase subunit interface; other site 754035010090 NMT1/THI5 like; Region: NMT1; pfam09084 754035010091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 754035010092 CHRD domain; Region: CHRD; pfam07452 754035010093 thiamine pyrophosphate protein; Validated; Region: PRK08199 754035010094 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035010095 PYR/PP interface [polypeptide binding]; other site 754035010096 dimer interface [polypeptide binding]; other site 754035010097 TPP binding site [chemical binding]; other site 754035010098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035010099 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 754035010100 TPP-binding site [chemical binding]; other site 754035010101 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 754035010102 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754035010103 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 754035010104 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035010105 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 754035010106 B1 nucleotide binding pocket [chemical binding]; other site 754035010107 B2 nucleotide binding pocket [chemical binding]; other site 754035010108 CAS motifs; other site 754035010109 active site 754035010110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035010111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035010112 metal binding site [ion binding]; metal-binding site 754035010113 active site 754035010114 I-site; other site 754035010115 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 754035010116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035010117 Walker A/P-loop; other site 754035010118 ATP binding site [chemical binding]; other site 754035010119 Q-loop/lid; other site 754035010120 ABC transporter signature motif; other site 754035010121 Walker B; other site 754035010122 D-loop; other site 754035010123 H-loop/switch region; other site 754035010124 ABC transporter; Region: ABC_tran_2; pfam12848 754035010125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035010126 Dam-replacing family; Region: DRP; pfam06044 754035010127 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 754035010128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035010129 S-adenosylmethionine binding site [chemical binding]; other site 754035010130 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 754035010131 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754035010132 dimer interface [polypeptide binding]; other site 754035010133 active site 754035010134 CoA binding pocket [chemical binding]; other site 754035010135 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035010136 MOSC domain; Region: MOSC; pfam03473 754035010137 short chain dehydrogenase; Provisional; Region: PRK08263 754035010138 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 754035010139 NADP binding site [chemical binding]; other site 754035010140 active site 754035010141 steroid binding site; other site 754035010142 Uncharacterized conserved protein [Function unknown]; Region: COG5586 754035010143 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 754035010144 homodimer interaction site [polypeptide binding]; other site 754035010145 cofactor binding site; other site 754035010146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035010147 putative Zn2+ binding site [ion binding]; other site 754035010148 putative DNA binding site [nucleotide binding]; other site 754035010149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754035010150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035010151 S-adenosylmethionine binding site [chemical binding]; other site 754035010152 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 754035010153 FAD binding site [chemical binding]; other site 754035010154 EamA-like transporter family; Region: EamA; pfam00892 754035010155 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 754035010156 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754035010157 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035010158 catalytic residue [active] 754035010159 Transglycosylase SLT domain; Region: SLT_2; pfam13406 754035010160 murein hydrolase B; Provisional; Region: PRK10760; cl17906 754035010161 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035010162 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 754035010163 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 754035010164 active site 754035010165 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035010166 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035010167 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 754035010168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035010169 non-specific DNA binding site [nucleotide binding]; other site 754035010170 salt bridge; other site 754035010171 sequence-specific DNA binding site [nucleotide binding]; other site 754035010172 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 754035010173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035010174 S-adenosylmethionine binding site [chemical binding]; other site 754035010175 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 754035010176 5-oxoprolinase; Region: PLN02666 754035010177 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 754035010178 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 754035010179 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 754035010180 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 754035010181 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 754035010182 putative metal binding site [ion binding]; other site 754035010183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035010184 HSP70 interaction site [polypeptide binding]; other site 754035010185 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 754035010186 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 754035010187 amidase catalytic site [active] 754035010188 Zn binding residues [ion binding]; other site 754035010189 substrate binding site [chemical binding]; other site 754035010190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035010191 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 754035010192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035010193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035010194 catalytic residue [active] 754035010195 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 754035010196 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 754035010197 cystathionine gamma-lyase; Validated; Region: PRK07582 754035010198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754035010199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035010200 catalytic residue [active] 754035010201 cell division protein MraZ; Reviewed; Region: PRK00326 754035010202 MraZ protein; Region: MraZ; pfam02381 754035010203 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 754035010204 MraW methylase family; Region: Methyltransf_5; cl17771 754035010205 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 754035010206 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 754035010207 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754035010208 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754035010209 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 754035010210 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754035010211 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754035010212 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754035010213 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 754035010214 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754035010215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754035010216 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 754035010217 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 754035010218 Mg++ binding site [ion binding]; other site 754035010219 putative catalytic motif [active] 754035010220 putative substrate binding site [chemical binding]; other site 754035010221 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 754035010222 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 754035010223 NAD(P) binding pocket [chemical binding]; other site 754035010224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754035010225 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754035010226 cell division protein FtsW; Region: ftsW; TIGR02614 754035010227 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 754035010228 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 754035010229 active site 754035010230 homodimer interface [polypeptide binding]; other site 754035010231 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 754035010232 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754035010233 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754035010234 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754035010235 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 754035010236 FAD binding domain; Region: FAD_binding_4; pfam01565 754035010237 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 754035010238 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 754035010239 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754035010240 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035010241 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 754035010242 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 754035010243 Cell division protein FtsQ; Region: FtsQ; pfam03799 754035010244 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 754035010245 Cell division protein FtsA; Region: FtsA; smart00842 754035010246 Cell division protein FtsA; Region: FtsA; pfam14450 754035010247 cell division protein FtsZ; Validated; Region: PRK09330 754035010248 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 754035010249 nucleotide binding site [chemical binding]; other site 754035010250 SulA interaction site; other site 754035010251 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 754035010252 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 754035010253 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 754035010254 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 754035010255 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 754035010256 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754035010257 Walker A/P-loop; other site 754035010258 ATP binding site [chemical binding]; other site 754035010259 Q-loop/lid; other site 754035010260 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754035010261 ABC transporter signature motif; other site 754035010262 Walker B; other site 754035010263 D-loop; other site 754035010264 H-loop/switch region; other site 754035010265 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 754035010266 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 754035010267 nucleotide binding pocket [chemical binding]; other site 754035010268 K-X-D-G motif; other site 754035010269 catalytic site [active] 754035010270 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 754035010271 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 754035010272 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 754035010273 Dimer interface [polypeptide binding]; other site 754035010274 BRCT sequence motif; other site 754035010275 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 754035010276 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 754035010277 classical (c) SDRs; Region: SDR_c; cd05233 754035010278 NAD(P) binding site [chemical binding]; other site 754035010279 active site 754035010280 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 754035010281 Predicted membrane protein [Function unknown]; Region: COG4541 754035010282 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035010283 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035010284 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 754035010285 active site 754035010286 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 754035010287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035010288 S-adenosylmethionine binding site [chemical binding]; other site 754035010289 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 754035010290 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 754035010291 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 754035010292 Cu(I) binding site [ion binding]; other site 754035010293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 754035010294 CreA protein; Region: CreA; pfam05981 754035010295 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 754035010296 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 754035010297 trimer interface [polypeptide binding]; other site 754035010298 active site 754035010299 substrate binding site [chemical binding]; other site 754035010300 CoA binding site [chemical binding]; other site 754035010301 Low affinity iron permease; Region: Iron_permease; pfam04120 754035010302 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 754035010303 classical (c) SDRs; Region: SDR_c; cd05233 754035010304 NAD(P) binding site [chemical binding]; other site 754035010305 active site 754035010306 Predicted integral membrane protein [Function unknown]; Region: COG3548 754035010307 Bacterial SH3 domain; Region: SH3_3; pfam08239 754035010308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035010310 putative substrate translocation pore; other site 754035010311 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 754035010312 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 754035010313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 754035010314 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 754035010315 Uncharacterized conserved protein [Function unknown]; Region: COG3461 754035010316 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 754035010317 Part of AAA domain; Region: AAA_19; pfam13245 754035010318 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 754035010319 Family description; Region: UvrD_C_2; pfam13538 754035010320 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 754035010321 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 754035010322 Trp docking motif [polypeptide binding]; other site 754035010323 putative active site [active] 754035010324 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 754035010325 response regulator; Provisional; Region: PRK13435 754035010326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035010327 active site 754035010328 phosphorylation site [posttranslational modification] 754035010329 intermolecular recognition site; other site 754035010330 dimerization interface [polypeptide binding]; other site 754035010331 hypothetical protein; Provisional; Region: PRK13559 754035010332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035010333 putative active site [active] 754035010334 heme pocket [chemical binding]; other site 754035010335 Histidine kinase; Region: HisKA_2; pfam07568 754035010336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035010337 ATP binding site [chemical binding]; other site 754035010338 Mg2+ binding site [ion binding]; other site 754035010339 G-X-G motif; other site 754035010340 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 754035010341 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 754035010342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035010343 putative DNA binding site [nucleotide binding]; other site 754035010344 putative Zn2+ binding site [ion binding]; other site 754035010345 AsnC family; Region: AsnC_trans_reg; pfam01037 754035010346 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754035010347 active site 754035010348 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035010349 FAD binding domain; Region: FAD_binding_4; pfam01565 754035010350 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 754035010351 AsmA family; Region: AsmA; pfam05170 754035010352 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754035010353 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754035010354 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 754035010355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035010356 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 754035010357 DNA binding residues [nucleotide binding] 754035010358 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035010359 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035010360 MarR family; Region: MarR_2; pfam12802 754035010361 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 754035010362 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754035010363 Cl- selectivity filter; other site 754035010364 Cl- binding residues [ion binding]; other site 754035010365 pore gating glutamate residue; other site 754035010366 dimer interface [polypeptide binding]; other site 754035010367 FOG: CBS domain [General function prediction only]; Region: COG0517 754035010368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 754035010369 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 754035010370 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 754035010371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 754035010372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035010373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035010374 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 754035010375 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 754035010376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010377 putative substrate translocation pore; other site 754035010378 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 754035010379 putative dimer interface [polypeptide binding]; other site 754035010380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035010381 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 754035010382 thymidylate synthase; Reviewed; Region: thyA; PRK01827 754035010383 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 754035010384 dimerization interface [polypeptide binding]; other site 754035010385 active site 754035010386 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 754035010387 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754035010388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035010389 molybdate ABC transporter permease protein; Reviewed; Region: modB; PRK09421 754035010390 putative PBP binding loops; other site 754035010391 ABC-ATPase subunit interface; other site 754035010392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035010393 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 754035010394 Walker A/P-loop; other site 754035010395 ATP binding site [chemical binding]; other site 754035010396 Q-loop/lid; other site 754035010397 ABC transporter signature motif; other site 754035010398 Walker B; other site 754035010399 D-loop; other site 754035010400 H-loop/switch region; other site 754035010401 TOBE domain; Region: TOBE; pfam03459 754035010402 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 754035010403 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 754035010404 active site 754035010405 SAM binding site [chemical binding]; other site 754035010406 homodimer interface [polypeptide binding]; other site 754035010407 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 754035010408 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035010409 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 754035010410 NADP+ binding site [chemical binding]; other site 754035010411 folate binding site [chemical binding]; other site 754035010412 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 754035010413 HflK protein; Region: hflK; TIGR01933 754035010414 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754035010415 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 754035010416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 754035010417 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 754035010418 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035010419 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035010420 protein binding site [polypeptide binding]; other site 754035010421 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035010422 protein binding site [polypeptide binding]; other site 754035010423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035010424 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035010425 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 754035010426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035010427 motif II; other site 754035010428 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 754035010429 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 754035010430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035010431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035010432 metal binding site [ion binding]; metal-binding site 754035010433 active site 754035010434 I-site; other site 754035010435 HerA helicase [Replication, recombination, and repair]; Region: COG0433 754035010436 Domain of unknown function DUF87; Region: DUF87; pfam01935 754035010437 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035010438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035010439 non-specific DNA binding site [nucleotide binding]; other site 754035010440 salt bridge; other site 754035010441 sequence-specific DNA binding site [nucleotide binding]; other site 754035010442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754035010443 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035010444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035010445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035010446 dimerization interface [polypeptide binding]; other site 754035010447 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 754035010448 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 754035010449 substrate binding pocket [chemical binding]; other site 754035010450 active site 754035010451 iron coordination sites [ion binding]; other site 754035010452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754035010453 Zn2+ binding site [ion binding]; other site 754035010454 Mg2+ binding site [ion binding]; other site 754035010455 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035010456 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 754035010457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 754035010458 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 754035010459 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035010460 PYR/PP interface [polypeptide binding]; other site 754035010461 dimer interface [polypeptide binding]; other site 754035010462 TPP binding site [chemical binding]; other site 754035010463 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035010464 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 754035010465 TPP-binding site [chemical binding]; other site 754035010466 dimer interface [polypeptide binding]; other site 754035010467 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 754035010468 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 754035010469 putative valine binding site [chemical binding]; other site 754035010470 dimer interface [polypeptide binding]; other site 754035010471 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 754035010472 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035010473 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035010474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035010475 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035010476 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035010477 Protein export membrane protein; Region: SecD_SecF; cl14618 754035010478 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 754035010479 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 754035010480 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 754035010481 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 754035010482 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 754035010483 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 754035010484 AAA domain; Region: AAA_30; pfam13604 754035010485 Family description; Region: UvrD_C_2; pfam13538 754035010486 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 754035010487 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 754035010488 active site 754035010489 hydrophilic channel; other site 754035010490 dimerization interface [polypeptide binding]; other site 754035010491 catalytic residues [active] 754035010492 active site lid [active] 754035010493 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 754035010494 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 754035010495 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 754035010496 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 754035010497 NADP binding site [chemical binding]; other site 754035010498 putative substrate binding site [chemical binding]; other site 754035010499 active site 754035010500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035010501 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754035010502 NAD(P) binding site [chemical binding]; other site 754035010503 active site 754035010504 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035010505 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035010506 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 754035010507 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035010508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035010509 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035010510 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754035010511 C-terminal domain interface [polypeptide binding]; other site 754035010512 GSH binding site (G-site) [chemical binding]; other site 754035010513 dimer interface [polypeptide binding]; other site 754035010514 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035010515 N-terminal domain interface [polypeptide binding]; other site 754035010516 dimer interface [polypeptide binding]; other site 754035010517 substrate binding pocket (H-site) [chemical binding]; other site 754035010518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035010519 MarR family; Region: MarR_2; pfam12802 754035010520 MarR family; Region: MarR_2; cl17246 754035010521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035010522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035010523 ketol-acid reductoisomerase; Provisional; Region: PRK05479 754035010524 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 754035010525 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 754035010526 BA14K-like protein; Region: BA14K; pfam07886 754035010527 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 754035010528 putative catalytic site [active] 754035010529 putative phosphate binding site [ion binding]; other site 754035010530 putative metal binding site [ion binding]; other site 754035010531 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 754035010532 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 754035010533 oligomeric interface; other site 754035010534 putative active site [active] 754035010535 homodimer interface [polypeptide binding]; other site 754035010536 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754035010537 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 754035010538 FtsX-like permease family; Region: FtsX; pfam02687 754035010539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754035010540 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754035010541 Walker A/P-loop; other site 754035010542 ATP binding site [chemical binding]; other site 754035010543 Q-loop/lid; other site 754035010544 ABC transporter signature motif; other site 754035010545 Walker B; other site 754035010546 D-loop; other site 754035010547 H-loop/switch region; other site 754035010548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035010549 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035010550 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035010551 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 754035010552 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 754035010553 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 754035010554 putative dimer interface [polypeptide binding]; other site 754035010555 active site pocket [active] 754035010556 putative cataytic base [active] 754035010557 cobalamin synthase; Reviewed; Region: cobS; PRK00235 754035010558 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 754035010559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035010560 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 754035010561 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 754035010562 active site 754035010563 SAM binding site [chemical binding]; other site 754035010564 homodimer interface [polypeptide binding]; other site 754035010565 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 754035010566 active site 754035010567 SAM binding site [chemical binding]; other site 754035010568 homodimer interface [polypeptide binding]; other site 754035010569 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 754035010570 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 754035010571 active site 754035010572 putative homodimer interface [polypeptide binding]; other site 754035010573 SAM binding site [chemical binding]; other site 754035010574 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 754035010575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035010576 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 754035010577 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 754035010578 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 754035010579 active site 754035010580 SAM binding site [chemical binding]; other site 754035010581 homodimer interface [polypeptide binding]; other site 754035010582 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 754035010583 active site 754035010584 SAM binding site [chemical binding]; other site 754035010585 homodimer interface [polypeptide binding]; other site 754035010586 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 754035010587 Precorrin-8X methylmutase; Region: CbiC; pfam02570 754035010588 precorrin-3B synthase; Region: CobG; TIGR02435 754035010589 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754035010590 cobaltochelatase, CobN subunit; Region: cobalto_cobN; TIGR02257 754035010591 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 754035010592 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 754035010593 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 754035010594 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 754035010595 Predicted metal-binding protein [Function unknown]; Region: COG5469 754035010596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 754035010597 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 754035010598 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 754035010599 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 754035010600 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 754035010601 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 754035010602 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 754035010603 NADH dehydrogenase subunit D; Validated; Region: PRK06075 754035010604 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 754035010605 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 754035010606 putative dimer interface [polypeptide binding]; other site 754035010607 [2Fe-2S] cluster binding site [ion binding]; other site 754035010608 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 754035010609 SLBB domain; Region: SLBB; pfam10531 754035010610 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 754035010611 Uncharacterized conserved protein [Function unknown]; Region: COG3743 754035010612 NADH dehydrogenase subunit G; Validated; Region: PRK09130 754035010613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035010614 catalytic loop [active] 754035010615 iron binding site [ion binding]; other site 754035010616 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 754035010617 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 754035010618 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 754035010619 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 754035010620 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 754035010621 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 754035010622 4Fe-4S binding domain; Region: Fer4; cl02805 754035010623 4Fe-4S binding domain; Region: Fer4; pfam00037 754035010624 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 754035010625 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 754035010626 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 754035010627 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 754035010628 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 754035010629 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 754035010630 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754035010631 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 754035010632 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754035010633 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 754035010634 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754035010635 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 754035010636 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 754035010637 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 754035010638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035010639 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 754035010640 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754035010641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035010642 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 754035010643 dimer interface [polypeptide binding]; other site 754035010644 substrate binding site [chemical binding]; other site 754035010645 metal binding site [ion binding]; metal-binding site 754035010646 Predicted secreted protein [Function unknown]; Region: COG5454 754035010647 prolyl-tRNA synthetase; Provisional; Region: PRK12325 754035010648 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 754035010649 dimer interface [polypeptide binding]; other site 754035010650 motif 1; other site 754035010651 active site 754035010652 motif 2; other site 754035010653 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035010654 active site 754035010655 motif 3; other site 754035010656 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 754035010657 anticodon binding site; other site 754035010658 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 754035010659 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754035010660 FtsX-like permease family; Region: FtsX; pfam02687 754035010661 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754035010662 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754035010663 Walker A/P-loop; other site 754035010664 ATP binding site [chemical binding]; other site 754035010665 Q-loop/lid; other site 754035010666 ABC transporter signature motif; other site 754035010667 Walker B; other site 754035010668 D-loop; other site 754035010669 H-loop/switch region; other site 754035010670 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 754035010671 hydrophobic ligand binding site; other site 754035010672 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 754035010673 active site 754035010674 putative substrate binding region [chemical binding]; other site 754035010675 lipoate-protein ligase B; Provisional; Region: PRK14341 754035010676 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 754035010677 CoA binding domain; Region: CoA_binding; smart00881 754035010678 CoA-ligase; Region: Ligase_CoA; pfam00549 754035010679 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 754035010680 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 754035010681 CoA-ligase; Region: Ligase_CoA; pfam00549 754035010682 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 754035010683 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 754035010684 homodimer interface [polypeptide binding]; other site 754035010685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035010686 catalytic residue [active] 754035010687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035010688 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035010689 active site 754035010690 phosphorylation site [posttranslational modification] 754035010691 intermolecular recognition site; other site 754035010692 dimerization interface [polypeptide binding]; other site 754035010693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035010694 DNA binding residues [nucleotide binding] 754035010695 dimerization interface [polypeptide binding]; other site 754035010696 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 754035010697 MgtE intracellular N domain; Region: MgtE_N; smart00924 754035010698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 754035010699 Divalent cation transporter; Region: MgtE; cl00786 754035010700 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 754035010701 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 754035010702 DNA binding residues [nucleotide binding] 754035010703 putative dimer interface [polypeptide binding]; other site 754035010704 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754035010705 Predicted membrane protein [Function unknown]; Region: COG3503 754035010706 Acyltransferase family; Region: Acyl_transf_3; pfam01757 754035010707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035010709 putative substrate translocation pore; other site 754035010710 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035010711 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035010712 [2Fe-2S] cluster binding site [ion binding]; other site 754035010713 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 754035010714 putative alpha subunit interface [polypeptide binding]; other site 754035010715 putative active site [active] 754035010716 putative substrate binding site [chemical binding]; other site 754035010717 Fe binding site [ion binding]; other site 754035010718 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 754035010719 Predicted integral membrane protein [Function unknown]; Region: COG5446 754035010720 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 754035010721 homotrimer interface [polypeptide binding]; other site 754035010722 Walker A motif; other site 754035010723 GTP binding site [chemical binding]; other site 754035010724 Walker B motif; other site 754035010725 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 754035010726 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 754035010727 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 754035010728 homodimer interface [polypeptide binding]; other site 754035010729 Walker A motif; other site 754035010730 ATP binding site [chemical binding]; other site 754035010731 hydroxycobalamin binding site [chemical binding]; other site 754035010732 Walker B motif; other site 754035010733 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270 754035010734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754035010735 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 754035010736 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035010737 catalytic residue [active] 754035010738 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 754035010739 Creatinine amidohydrolase; Region: Creatininase; pfam02633 754035010740 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754035010741 homotrimer interaction site [polypeptide binding]; other site 754035010742 putative active site [active] 754035010743 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 754035010744 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035010745 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035010746 Walker A/P-loop; other site 754035010747 ATP binding site [chemical binding]; other site 754035010748 Q-loop/lid; other site 754035010749 ABC transporter signature motif; other site 754035010750 Walker B; other site 754035010751 D-loop; other site 754035010752 H-loop/switch region; other site 754035010753 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035010754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010755 dimer interface [polypeptide binding]; other site 754035010756 conserved gate region; other site 754035010757 putative PBP binding loops; other site 754035010758 ABC-ATPase subunit interface; other site 754035010759 cytosine deaminase-like protein; Validated; Region: PRK07583 754035010760 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 754035010761 active site 754035010762 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035010763 FAD binding domain; Region: FAD_binding_4; pfam01565 754035010764 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 754035010765 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035010766 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 754035010767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035010768 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035010769 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010770 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035010771 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010772 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 754035010773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035010774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035010775 homodimer interface [polypeptide binding]; other site 754035010776 catalytic residue [active] 754035010777 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 754035010778 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 754035010779 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035010780 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010781 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035010782 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035010783 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010784 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 754035010785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035010786 non-specific DNA binding site [nucleotide binding]; other site 754035010787 salt bridge; other site 754035010788 sequence-specific DNA binding site [nucleotide binding]; other site 754035010789 Cupin domain; Region: Cupin_2; pfam07883 754035010790 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 754035010791 putative FMN binding site [chemical binding]; other site 754035010792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035010794 putative substrate translocation pore; other site 754035010795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010796 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 754035010797 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 754035010798 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 754035010799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035010800 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010801 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 754035010802 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 754035010803 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010804 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 754035010805 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754035010806 hypothetical protein; Validated; Region: PRK08238 754035010807 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754035010808 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 754035010809 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035010810 FAD binding domain; Region: FAD_binding_4; pfam01565 754035010811 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 754035010812 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035010813 extended (e) SDRs; Region: SDR_e; cd08946 754035010814 NAD(P) binding site [chemical binding]; other site 754035010815 active site 754035010816 substrate binding site [chemical binding]; other site 754035010817 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 754035010818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035010819 inhibitor-cofactor binding pocket; inhibition site 754035010820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035010821 catalytic residue [active] 754035010822 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 754035010823 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035010824 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010825 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035010826 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010827 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 754035010828 metal ion-dependent adhesion site (MIDAS); other site 754035010829 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 754035010830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035010831 substrate binding pocket [chemical binding]; other site 754035010832 membrane-bound complex binding site; other site 754035010833 hinge residues; other site 754035010834 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035010835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010836 dimer interface [polypeptide binding]; other site 754035010837 conserved gate region; other site 754035010838 putative PBP binding loops; other site 754035010839 ABC-ATPase subunit interface; other site 754035010840 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035010841 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035010842 Walker A/P-loop; other site 754035010843 ATP binding site [chemical binding]; other site 754035010844 Q-loop/lid; other site 754035010845 ABC transporter signature motif; other site 754035010846 Walker B; other site 754035010847 D-loop; other site 754035010848 H-loop/switch region; other site 754035010849 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035010850 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035010851 conserved cys residue [active] 754035010852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035010853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035010854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035010855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035010856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035010857 dimerization interface [polypeptide binding]; other site 754035010858 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754035010859 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 754035010860 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 754035010861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035010862 catalytic loop [active] 754035010863 iron binding site [ion binding]; other site 754035010864 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 754035010865 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 754035010866 substrate binding pocket [chemical binding]; other site 754035010867 dimer interface [polypeptide binding]; other site 754035010868 inhibitor binding site; inhibition site 754035010869 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 754035010870 FAD binding site [chemical binding]; other site 754035010871 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 754035010872 Virulence factor; Region: Virulence_fact; pfam13769 754035010873 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 754035010874 putative active site [active] 754035010875 putative cosubstrate binding site; other site 754035010876 putative substrate binding site [chemical binding]; other site 754035010877 catalytic site [active] 754035010878 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035010879 extended (e) SDRs; Region: SDR_e; cd08946 754035010880 NAD(P) binding site [chemical binding]; other site 754035010881 active site 754035010882 substrate binding site [chemical binding]; other site 754035010883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035010884 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 754035010885 Entericidin EcnA/B family; Region: Entericidin; cl02322 754035010886 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 754035010887 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 754035010888 B12 binding site [chemical binding]; other site 754035010889 cobalt ligand [ion binding]; other site 754035010890 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 754035010891 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 754035010892 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 754035010893 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 754035010894 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 754035010895 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 754035010896 Predicted flavoproteins [General function prediction only]; Region: COG2081 754035010897 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010898 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 754035010899 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 754035010900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035010901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035010902 DNA binding residues [nucleotide binding] 754035010903 von Willebrand factor; Region: vWF_A; pfam12450 754035010904 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 754035010905 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 754035010906 metal ion-dependent adhesion site (MIDAS); other site 754035010907 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 754035010908 methionine synthase I; Validated; Region: PRK07534 754035010909 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 754035010910 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035010911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035010912 non-specific DNA binding site [nucleotide binding]; other site 754035010913 salt bridge; other site 754035010914 sequence-specific DNA binding site [nucleotide binding]; other site 754035010915 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 754035010916 Fatty acid desaturase; Region: FA_desaturase; pfam00487 754035010917 putative di-iron ligands [ion binding]; other site 754035010918 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 754035010919 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035010920 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035010921 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035010922 active site 754035010923 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035010924 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035010925 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035010926 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035010927 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 754035010928 putative active site [active] 754035010929 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 754035010930 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 754035010931 PLD-like domain; Region: PLDc_2; pfam13091 754035010932 putative active site [active] 754035010933 catalytic site [active] 754035010934 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 754035010935 putative active site [active] 754035010936 catalytic site [active] 754035010937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010939 putative substrate translocation pore; other site 754035010940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035010941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035010942 putative substrate translocation pore; other site 754035010943 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 754035010944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035010945 putative aminotransferase; Validated; Region: PRK07480 754035010946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035010947 inhibitor-cofactor binding pocket; inhibition site 754035010948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035010949 catalytic residue [active] 754035010950 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 754035010951 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035010952 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 754035010953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035010954 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 754035010955 substrate binding pocket [chemical binding]; other site 754035010956 FAD binding site [chemical binding]; other site 754035010957 catalytic base [active] 754035010958 cobyric acid synthase; Provisional; Region: PRK00784 754035010959 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035010960 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035010961 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 754035010962 catalytic triad [active] 754035010963 hypothetical protein; Provisional; Region: PRK10621 754035010964 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 754035010965 tellurium resistance terB-like protein; Region: terB_like; cd07177 754035010966 metal binding site [ion binding]; metal-binding site 754035010967 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 754035010968 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035010969 Walker A/P-loop; other site 754035010970 ATP binding site [chemical binding]; other site 754035010971 Q-loop/lid; other site 754035010972 ABC transporter signature motif; other site 754035010973 Walker B; other site 754035010974 D-loop; other site 754035010975 H-loop/switch region; other site 754035010976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035010977 Walker A/P-loop; other site 754035010978 ATP binding site [chemical binding]; other site 754035010979 Q-loop/lid; other site 754035010980 ABC transporter signature motif; other site 754035010981 Walker B; other site 754035010982 D-loop; other site 754035010983 H-loop/switch region; other site 754035010984 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035010985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010986 dimer interface [polypeptide binding]; other site 754035010987 conserved gate region; other site 754035010988 putative PBP binding loops; other site 754035010989 ABC-ATPase subunit interface; other site 754035010990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035010991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035010992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035010993 dimer interface [polypeptide binding]; other site 754035010994 conserved gate region; other site 754035010995 putative PBP binding loops; other site 754035010996 ABC-ATPase subunit interface; other site 754035010997 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035010998 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 754035010999 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 754035011000 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like6; cd08011 754035011001 metal binding site [ion binding]; metal-binding site 754035011002 putative dimer interface [polypeptide binding]; other site 754035011003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035011004 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035011005 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754035011006 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754035011007 putative acyl-acceptor binding pocket; other site 754035011008 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035011009 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 754035011010 putative NAD(P) binding site [chemical binding]; other site 754035011011 structural Zn binding site [ion binding]; other site 754035011012 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 754035011013 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035011014 dimer interface [polypeptide binding]; other site 754035011015 active site 754035011016 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 754035011017 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 754035011018 active site 754035011019 acyl carrier protein; Provisional; Region: PRK06508 754035011020 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754035011021 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 754035011022 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035011023 catalytic core [active] 754035011024 Predicted permeases [General function prediction only]; Region: COG0679 754035011025 succinic semialdehyde dehydrogenase; Region: PLN02278 754035011026 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754035011027 tetramerization interface [polypeptide binding]; other site 754035011028 NAD(P) binding site [chemical binding]; other site 754035011029 catalytic residues [active] 754035011030 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 754035011031 active site 754035011032 catalytic residues [active] 754035011033 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754035011034 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035011035 substrate binding site [chemical binding]; other site 754035011036 ATP binding site [chemical binding]; other site 754035011037 YtkA-like; Region: YtkA; pfam13115 754035011038 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 754035011039 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035011040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035011041 putative DNA binding site [nucleotide binding]; other site 754035011042 putative Zn2+ binding site [ion binding]; other site 754035011043 AsnC family; Region: AsnC_trans_reg; pfam01037 754035011044 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 754035011045 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 754035011046 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 754035011047 Glutamate binding site [chemical binding]; other site 754035011048 NAD binding site [chemical binding]; other site 754035011049 catalytic residues [active] 754035011050 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 754035011051 NAD(P) binding site [chemical binding]; other site 754035011052 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 754035011053 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 754035011054 TonB C terminal; Region: TonB_2; pfam13103 754035011055 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 754035011056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754035011057 N-terminal plug; other site 754035011058 ligand-binding site [chemical binding]; other site 754035011059 Hemin uptake protein hemP; Region: hemP; cl10043 754035011060 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 754035011061 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754035011062 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754035011063 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 754035011064 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 754035011065 putative hemin binding site; other site 754035011066 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754035011067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754035011068 ABC-ATPase subunit interface; other site 754035011069 dimer interface [polypeptide binding]; other site 754035011070 putative PBP binding regions; other site 754035011071 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 754035011072 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754035011073 Walker A/P-loop; other site 754035011074 ATP binding site [chemical binding]; other site 754035011075 Q-loop/lid; other site 754035011076 ABC transporter signature motif; other site 754035011077 Walker B; other site 754035011078 D-loop; other site 754035011079 H-loop/switch region; other site 754035011080 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 754035011081 Rrf2 family protein; Region: rrf2_super; TIGR00738 754035011082 Predicted membrane protein [Function unknown]; Region: COG2733 754035011083 Uncharacterized conserved protein [Function unknown]; Region: COG5490 754035011084 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 754035011085 putative active site [active] 754035011086 putative catalytic site [active] 754035011087 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035011088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035011089 DNA-binding site [nucleotide binding]; DNA binding site 754035011090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035011091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035011092 homodimer interface [polypeptide binding]; other site 754035011093 catalytic residue [active] 754035011094 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035011095 EamA-like transporter family; Region: EamA; pfam00892 754035011096 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 754035011097 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 754035011098 putative NAD(P) binding site [chemical binding]; other site 754035011099 catalytic Zn binding site [ion binding]; other site 754035011100 structural Zn binding site [ion binding]; other site 754035011101 Predicted transcriptional regulators [Transcription]; Region: COG1733 754035011102 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754035011103 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035011104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035011105 putative substrate translocation pore; other site 754035011106 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 754035011107 maleylacetoacetate isomerase; Region: maiA; TIGR01262 754035011108 C-terminal domain interface [polypeptide binding]; other site 754035011109 GSH binding site (G-site) [chemical binding]; other site 754035011110 putative dimer interface [polypeptide binding]; other site 754035011111 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 754035011112 dimer interface [polypeptide binding]; other site 754035011113 N-terminal domain interface [polypeptide binding]; other site 754035011114 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 754035011115 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 754035011116 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035011117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035011118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011119 active site 754035011120 phosphorylation site [posttranslational modification] 754035011121 intermolecular recognition site; other site 754035011122 dimerization interface [polypeptide binding]; other site 754035011123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035011124 DNA binding residues [nucleotide binding] 754035011125 dimerization interface [polypeptide binding]; other site 754035011126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035011127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035011128 dimer interface [polypeptide binding]; other site 754035011129 phosphorylation site [posttranslational modification] 754035011130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035011131 ATP binding site [chemical binding]; other site 754035011132 Mg2+ binding site [ion binding]; other site 754035011133 G-X-G motif; other site 754035011134 Response regulator receiver domain; Region: Response_reg; pfam00072 754035011135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011136 active site 754035011137 phosphorylation site [posttranslational modification] 754035011138 intermolecular recognition site; other site 754035011139 dimerization interface [polypeptide binding]; other site 754035011140 Uncharacterized conserved protein [Function unknown]; Region: COG3287 754035011141 FIST N domain; Region: FIST; pfam08495 754035011142 FIST C domain; Region: FIST_C; pfam10442 754035011143 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035011144 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035011145 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035011146 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035011147 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035011148 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035011149 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 754035011150 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035011151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035011152 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 754035011153 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 754035011154 putative hydrophobic ligand binding site [chemical binding]; other site 754035011155 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 754035011156 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754035011157 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754035011158 Repression of heat shock gene expression (ROSE) element; Mesau_03735 754035011159 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754035011160 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754035011161 putative dimer interface [polypeptide binding]; other site 754035011162 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035011163 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 754035011164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035011165 S-adenosylmethionine binding site [chemical binding]; other site 754035011166 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 754035011167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 754035011168 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 754035011169 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754035011170 HIGH motif; other site 754035011171 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754035011172 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754035011173 active site 754035011174 KMSKS motif; other site 754035011175 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 754035011176 tRNA binding surface [nucleotide binding]; other site 754035011177 anticodon binding site; other site 754035011178 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 754035011179 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 754035011180 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 754035011181 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754035011182 Sel1-like repeats; Region: SEL1; smart00671 754035011183 Sel1-like repeats; Region: SEL1; smart00671 754035011184 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 754035011185 putative catalytic site [active] 754035011186 putative phosphate binding site [ion binding]; other site 754035011187 active site 754035011188 metal binding site A [ion binding]; metal-binding site 754035011189 DNA binding site [nucleotide binding] 754035011190 putative AP binding site [nucleotide binding]; other site 754035011191 putative metal binding site B [ion binding]; other site 754035011192 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 754035011193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035011194 active site 754035011195 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 754035011196 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 754035011197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754035011198 Zn2+ binding site [ion binding]; other site 754035011199 Mg2+ binding site [ion binding]; other site 754035011200 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 754035011201 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 754035011202 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 754035011203 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 754035011204 active site 754035011205 HIGH motif; other site 754035011206 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754035011207 KMSK motif region; other site 754035011208 tRNA binding surface [nucleotide binding]; other site 754035011209 DALR anticodon binding domain; Region: DALR_1; smart00836 754035011210 anticodon binding site; other site 754035011211 Sporulation related domain; Region: SPOR; pfam05036 754035011212 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 754035011213 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 754035011214 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 754035011215 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 754035011216 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 754035011217 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 754035011218 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 754035011219 seryl-tRNA synthetase; Provisional; Region: PRK05431 754035011220 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 754035011221 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 754035011222 dimer interface [polypeptide binding]; other site 754035011223 active site 754035011224 motif 1; other site 754035011225 motif 2; other site 754035011226 motif 3; other site 754035011227 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 754035011228 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 754035011229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035011230 S-adenosylmethionine binding site [chemical binding]; other site 754035011231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754035011232 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754035011233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754035011234 Peptidase family M23; Region: Peptidase_M23; pfam01551 754035011235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035011236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035011237 NAD(P) binding site [chemical binding]; other site 754035011238 active site 754035011239 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754035011240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035011241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035011242 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 754035011243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035011244 Walker A motif; other site 754035011245 ATP binding site [chemical binding]; other site 754035011246 Walker B motif; other site 754035011247 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 754035011248 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 754035011249 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 754035011250 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 754035011251 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 754035011252 Protein export membrane protein; Region: SecD_SecF; pfam02355 754035011253 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 754035011254 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 754035011255 substrate binding pocket [chemical binding]; other site 754035011256 substrate-Mg2+ binding site; other site 754035011257 aspartate-rich region 1; other site 754035011258 aspartate-rich region 2; other site 754035011259 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 754035011260 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 754035011261 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 754035011262 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 754035011263 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 754035011264 Glucose inhibited division protein A; Region: GIDA; pfam01134 754035011265 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035011266 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035011267 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 754035011268 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 754035011269 trigger factor; Provisional; Region: tig; PRK01490 754035011270 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754035011271 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 754035011272 hypothetical protein; Reviewed; Region: PRK00024 754035011273 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 754035011274 MPN+ (JAMM) motif; other site 754035011275 Zinc-binding site [ion binding]; other site 754035011276 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 754035011277 active site 754035011278 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035011279 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035011280 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035011281 TadE-like protein; Region: TadE; pfam07811 754035011282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 754035011283 Peptidase M15; Region: Peptidase_M15_3; cl01194 754035011284 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 754035011285 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 754035011286 aminotransferase; Validated; Region: PRK09148 754035011287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035011288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035011289 homodimer interface [polypeptide binding]; other site 754035011290 catalytic residue [active] 754035011291 homoserine dehydrogenase; Provisional; Region: PRK06349 754035011292 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754035011293 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 754035011294 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 754035011295 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 754035011296 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 754035011297 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 754035011298 putative active site [active] 754035011299 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 754035011300 DHH family; Region: DHH; pfam01368 754035011301 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035011302 RibD C-terminal domain; Region: RibD_C; pfam01872 754035011303 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 754035011304 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 754035011305 active site 754035011306 nucleophile elbow; other site 754035011307 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 754035011308 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 754035011309 GTP cyclohydrolase I; Provisional; Region: PLN03044 754035011310 active site 754035011311 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 754035011312 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 754035011313 trimerization site [polypeptide binding]; other site 754035011314 active site 754035011315 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035011316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035011317 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035011318 dimerization interface [polypeptide binding]; other site 754035011319 substrate binding pocket [chemical binding]; other site 754035011320 hypothetical protein; Validated; Region: PRK00041 754035011321 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 754035011322 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 754035011323 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 754035011324 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754035011325 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 754035011326 active site 754035011327 dimer interface [polypeptide binding]; other site 754035011328 motif 1; other site 754035011329 motif 2; other site 754035011330 motif 3; other site 754035011331 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 754035011332 anticodon binding site; other site 754035011333 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 754035011334 putative acyl-acceptor binding pocket; other site 754035011335 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 754035011336 putative FMN binding site [chemical binding]; other site 754035011337 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 754035011338 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 754035011339 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 754035011340 putative active site [active] 754035011341 putative catalytic site [active] 754035011342 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 754035011343 Fusaric acid resistance protein family; Region: FUSC; pfam04632 754035011344 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 754035011345 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 754035011346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035011347 Mg2+ binding site [ion binding]; other site 754035011348 G-X-G motif; other site 754035011349 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754035011350 anchoring element; other site 754035011351 dimer interface [polypeptide binding]; other site 754035011352 ATP binding site [chemical binding]; other site 754035011353 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 754035011354 active site 754035011355 metal binding site [ion binding]; metal-binding site 754035011356 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754035011357 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 754035011358 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 754035011359 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 754035011360 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 754035011361 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754035011362 Response regulator receiver domain; Region: Response_reg; pfam00072 754035011363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011364 active site 754035011365 phosphorylation site [posttranslational modification] 754035011366 intermolecular recognition site; other site 754035011367 dimerization interface [polypeptide binding]; other site 754035011368 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754035011369 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 754035011370 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 754035011371 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754035011372 ATP binding site [chemical binding]; other site 754035011373 Walker A motif; other site 754035011374 hexamer interface [polypeptide binding]; other site 754035011375 Walker B motif; other site 754035011376 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754035011377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035011378 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 754035011379 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035011380 TPR repeat; Region: TPR_11; pfam13414 754035011381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035011382 binding surface 754035011383 TPR motif; other site 754035011384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035011385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035011386 metal binding site [ion binding]; metal-binding site 754035011387 active site 754035011388 I-site; other site 754035011389 glycine dehydrogenase; Provisional; Region: PRK05367 754035011390 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 754035011391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035011392 tetramer interface [polypeptide binding]; other site 754035011393 catalytic residue [active] 754035011394 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 754035011395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035011396 catalytic residue [active] 754035011397 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 754035011398 lipoyl attachment site [posttranslational modification]; other site 754035011399 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 754035011400 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035011401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035011402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035011403 Coenzyme A binding pocket [chemical binding]; other site 754035011404 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 754035011405 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 754035011406 Moco binding site; other site 754035011407 metal coordination site [ion binding]; other site 754035011408 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 754035011409 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 754035011410 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 754035011411 Predicted membrane protein [Function unknown]; Region: COG4291 754035011412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 754035011413 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 754035011414 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 754035011415 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 754035011416 substrate binding site [chemical binding]; other site 754035011417 catalytic Zn binding site [ion binding]; other site 754035011418 NAD binding site [chemical binding]; other site 754035011419 structural Zn binding site [ion binding]; other site 754035011420 dimer interface [polypeptide binding]; other site 754035011421 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 754035011422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035011423 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 754035011424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754035011425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754035011426 carboxyltransferase (CT) interaction site; other site 754035011427 biotinylation site [posttranslational modification]; other site 754035011428 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 754035011429 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 754035011430 putative active site [active] 754035011431 putative PHP Thumb interface [polypeptide binding]; other site 754035011432 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754035011433 generic binding surface II; other site 754035011434 generic binding surface I; other site 754035011435 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035011436 EamA-like transporter family; Region: EamA; pfam00892 754035011437 DNA polymerase IV; Provisional; Region: PRK02794 754035011438 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754035011439 active site 754035011440 DNA binding site [nucleotide binding] 754035011441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035011442 Coenzyme A binding pocket [chemical binding]; other site 754035011443 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 754035011444 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035011445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011446 active site 754035011447 phosphorylation site [posttranslational modification] 754035011448 intermolecular recognition site; other site 754035011449 dimerization interface [polypeptide binding]; other site 754035011450 response regulator PleD; Reviewed; Region: pleD; PRK09581 754035011451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011452 active site 754035011453 phosphorylation site [posttranslational modification] 754035011454 intermolecular recognition site; other site 754035011455 dimerization interface [polypeptide binding]; other site 754035011456 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035011457 metal binding site [ion binding]; metal-binding site 754035011458 active site 754035011459 I-site; other site 754035011460 hypothetical protein; Provisional; Region: PRK06834 754035011461 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035011462 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035011463 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035011464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035011465 DNA-binding site [nucleotide binding]; DNA binding site 754035011466 FCD domain; Region: FCD; pfam07729 754035011467 hypothetical protein; Provisional; Region: PRK05968 754035011468 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754035011469 homodimer interface [polypeptide binding]; other site 754035011470 substrate-cofactor binding pocket; other site 754035011471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035011472 catalytic residue [active] 754035011473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035011474 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035011475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035011476 dimer interface [polypeptide binding]; other site 754035011477 conserved gate region; other site 754035011478 putative PBP binding loops; other site 754035011479 ABC-ATPase subunit interface; other site 754035011480 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035011481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035011482 dimer interface [polypeptide binding]; other site 754035011483 conserved gate region; other site 754035011484 putative PBP binding loops; other site 754035011485 ABC-ATPase subunit interface; other site 754035011486 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035011487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035011488 Walker A/P-loop; other site 754035011489 ATP binding site [chemical binding]; other site 754035011490 Q-loop/lid; other site 754035011491 ABC transporter signature motif; other site 754035011492 Walker B; other site 754035011493 D-loop; other site 754035011494 H-loop/switch region; other site 754035011495 TOBE domain; Region: TOBE_2; pfam08402 754035011496 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 754035011497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 754035011498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035011499 putative substrate translocation pore; other site 754035011500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035011501 hypothetical protein; Provisional; Region: PRK05978 754035011502 ribonuclease R; Region: RNase_R; TIGR02063 754035011503 RNB domain; Region: RNB; pfam00773 754035011504 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 754035011505 RNA binding site [nucleotide binding]; other site 754035011506 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 754035011507 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 754035011508 active site 754035011509 interdomain interaction site; other site 754035011510 putative metal-binding site [ion binding]; other site 754035011511 nucleotide binding site [chemical binding]; other site 754035011512 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 754035011513 domain I; other site 754035011514 DNA binding groove [nucleotide binding] 754035011515 phosphate binding site [ion binding]; other site 754035011516 domain II; other site 754035011517 domain III; other site 754035011518 nucleotide binding site [chemical binding]; other site 754035011519 catalytic site [active] 754035011520 domain IV; other site 754035011521 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754035011522 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754035011523 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754035011524 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754035011525 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 754035011526 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 754035011527 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 754035011528 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 754035011529 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 754035011530 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 754035011531 Substrate binding site; other site 754035011532 Mg++ binding site; other site 754035011533 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 754035011534 active site 754035011535 substrate binding site [chemical binding]; other site 754035011536 CoA binding site [chemical binding]; other site 754035011537 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 754035011538 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 754035011539 glutaminase active site [active] 754035011540 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754035011541 dimer interface [polypeptide binding]; other site 754035011542 active site 754035011543 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754035011544 dimer interface [polypeptide binding]; other site 754035011545 active site 754035011546 Uncharacterized conserved protein [Function unknown]; Region: COG2928 754035011547 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 754035011548 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 754035011549 generic binding surface II; other site 754035011550 ssDNA binding site; other site 754035011551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035011552 ATP binding site [chemical binding]; other site 754035011553 putative Mg++ binding site [ion binding]; other site 754035011554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035011555 nucleotide binding region [chemical binding]; other site 754035011556 ATP-binding site [chemical binding]; other site 754035011557 Uncharacterized conserved protein [Function unknown]; Region: COG2938 754035011558 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 754035011559 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 754035011560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035011561 ATP binding site [chemical binding]; other site 754035011562 putative Mg++ binding site [ion binding]; other site 754035011563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035011564 nucleotide binding region [chemical binding]; other site 754035011565 ATP-binding site [chemical binding]; other site 754035011566 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 754035011567 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 754035011568 Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048 754035011569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035011570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035011571 metal binding site [ion binding]; metal-binding site 754035011572 active site 754035011573 I-site; other site 754035011574 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035011575 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 754035011576 Hemerythrin-like domain; Region: Hr-like; cd12108 754035011577 Fe binding site [ion binding]; other site 754035011578 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754035011579 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 754035011580 Predicted membrane protein [Function unknown]; Region: COG4420 754035011581 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 754035011582 NAD synthetase; Provisional; Region: PRK13981 754035011583 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 754035011584 multimer interface [polypeptide binding]; other site 754035011585 active site 754035011586 catalytic triad [active] 754035011587 protein interface 1 [polypeptide binding]; other site 754035011588 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 754035011589 homodimer interface [polypeptide binding]; other site 754035011590 NAD binding pocket [chemical binding]; other site 754035011591 ATP binding pocket [chemical binding]; other site 754035011592 Mg binding site [ion binding]; other site 754035011593 active-site loop [active] 754035011594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035011595 Coenzyme A binding pocket [chemical binding]; other site 754035011596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035011597 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035011598 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 754035011599 Walker A/P-loop; other site 754035011600 ATP binding site [chemical binding]; other site 754035011601 Q-loop/lid; other site 754035011602 ABC transporter signature motif; other site 754035011603 Walker B; other site 754035011604 D-loop; other site 754035011605 H-loop/switch region; other site 754035011606 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 754035011607 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754035011608 HIGH motif; other site 754035011609 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754035011610 active site 754035011611 KMSKS motif; other site 754035011612 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 754035011613 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035011614 malic enzyme; Reviewed; Region: PRK12862 754035011615 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754035011616 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 754035011617 putative NAD(P) binding site [chemical binding]; other site 754035011618 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 754035011619 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 754035011620 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754035011621 putative NAD(P) binding site [chemical binding]; other site 754035011622 putative active site [active] 754035011623 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 754035011624 putative active site [active] 754035011625 putative metal binding site [ion binding]; other site 754035011626 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 754035011627 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 754035011628 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 754035011629 active site 754035011630 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 754035011631 Permease; Region: Permease; pfam02405 754035011632 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 754035011633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035011634 Walker A/P-loop; other site 754035011635 ATP binding site [chemical binding]; other site 754035011636 Q-loop/lid; other site 754035011637 ABC transporter signature motif; other site 754035011638 Walker B; other site 754035011639 D-loop; other site 754035011640 H-loop/switch region; other site 754035011641 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 754035011642 mce related protein; Region: MCE; pfam02470 754035011643 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 754035011644 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 754035011645 active site 754035011646 catalytic site [active] 754035011647 substrate binding site [chemical binding]; other site 754035011648 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 754035011649 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 754035011650 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754035011651 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035011652 catalytic loop [active] 754035011653 iron binding site [ion binding]; other site 754035011654 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 754035011655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035011656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035011657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035011658 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035011659 putative substrate translocation pore; other site 754035011660 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 754035011661 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 754035011662 dihydropteroate synthase; Region: DHPS; TIGR01496 754035011663 substrate binding pocket [chemical binding]; other site 754035011664 dimer interface [polypeptide binding]; other site 754035011665 inhibitor binding site; inhibition site 754035011666 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 754035011667 active site 754035011668 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 754035011669 catalytic center binding site [active] 754035011670 ATP binding site [chemical binding]; other site 754035011671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 754035011672 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 754035011673 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 754035011674 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 754035011675 TrkA-N domain; Region: TrkA_N; pfam02254 754035011676 Cupin; Region: Cupin_6; pfam12852 754035011677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035011678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035011679 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035011680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 754035011681 Predicted membrane protein [Function unknown]; Region: COG3768 754035011682 Domain of unknown function (DUF697); Region: DUF697; cl12064 754035011683 YcjX-like family, DUF463; Region: DUF463; cl01193 754035011684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035011685 catalytic core [active] 754035011686 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 754035011687 PAS domain; Region: PAS; smart00091 754035011688 PAS domain; Region: PAS_9; pfam13426 754035011689 PAS fold; Region: PAS_4; pfam08448 754035011690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035011691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035011692 dimer interface [polypeptide binding]; other site 754035011693 phosphorylation site [posttranslational modification] 754035011694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035011695 ATP binding site [chemical binding]; other site 754035011696 Mg2+ binding site [ion binding]; other site 754035011697 G-X-G motif; other site 754035011698 Response regulator receiver domain; Region: Response_reg; pfam00072 754035011699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035011700 active site 754035011701 phosphorylation site [posttranslational modification] 754035011702 intermolecular recognition site; other site 754035011703 dimerization interface [polypeptide binding]; other site 754035011704 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 754035011705 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 754035011706 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 754035011707 dimer interface [polypeptide binding]; other site 754035011708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035011709 active site 754035011710 metal binding site [ion binding]; metal-binding site 754035011711 glutathione binding site [chemical binding]; other site 754035011712 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 754035011713 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 754035011714 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035011715 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035011716 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 754035011717 putative ligand binding site [chemical binding]; other site 754035011718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035011719 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035011720 TM-ABC transporter signature motif; other site 754035011721 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035011722 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035011723 TM-ABC transporter signature motif; other site 754035011724 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 754035011725 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035011726 Walker A/P-loop; other site 754035011727 ATP binding site [chemical binding]; other site 754035011728 Q-loop/lid; other site 754035011729 ABC transporter signature motif; other site 754035011730 Walker B; other site 754035011731 D-loop; other site 754035011732 H-loop/switch region; other site 754035011733 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 754035011734 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035011735 Walker A/P-loop; other site 754035011736 ATP binding site [chemical binding]; other site 754035011737 Q-loop/lid; other site 754035011738 ABC transporter signature motif; other site 754035011739 Walker B; other site 754035011740 D-loop; other site 754035011741 H-loop/switch region; other site 754035011742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035011743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035011744 metal binding site [ion binding]; metal-binding site 754035011745 active site 754035011746 I-site; other site 754035011747 Uncharacterized conserved protein [Function unknown]; Region: COG1801 754035011748 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 754035011749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035011750 Coenzyme A binding pocket [chemical binding]; other site 754035011751 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 754035011752 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754035011753 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754035011754 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 754035011755 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 754035011756 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754035011757 oligomer interface [polypeptide binding]; other site 754035011758 active site residues [active] 754035011759 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 754035011760 putative hydrophobic ligand binding site [chemical binding]; other site 754035011761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035011762 dimerization interface [polypeptide binding]; other site 754035011763 putative DNA binding site [nucleotide binding]; other site 754035011764 putative Zn2+ binding site [ion binding]; other site 754035011765 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 754035011766 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754035011767 dimer interface [polypeptide binding]; other site 754035011768 ssDNA binding site [nucleotide binding]; other site 754035011769 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754035011770 OsmC-like protein; Region: OsmC; cl00767 754035011771 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 754035011772 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 754035011773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035011774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035011775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035011776 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 754035011777 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754035011778 CAP-like domain; other site 754035011779 active site 754035011780 primary dimer interface [polypeptide binding]; other site 754035011781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035011782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035011783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035011784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035011785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035011786 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 754035011787 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 754035011788 active site 754035011789 (T/H)XGH motif; other site 754035011790 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 754035011791 active site 754035011792 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 754035011793 active site 754035011794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 754035011795 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 754035011796 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 754035011797 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 754035011798 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 754035011799 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035011800 AsnC family; Region: AsnC_trans_reg; pfam01037 754035011801 Uncharacterized conserved protein [Function unknown]; Region: COG2308 754035011802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 754035011803 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 754035011804 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035011805 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 754035011806 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 754035011807 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 754035011808 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 754035011809 tyrosine decarboxylase; Region: PLN02880 754035011810 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 754035011811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035011812 catalytic residue [active] 754035011813 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035011814 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754035011815 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035011816 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 754035011817 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 754035011818 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035011819 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754035011820 Walker A/P-loop; other site 754035011821 ATP binding site [chemical binding]; other site 754035011822 Q-loop/lid; other site 754035011823 ABC transporter signature motif; other site 754035011824 Walker B; other site 754035011825 D-loop; other site 754035011826 H-loop/switch region; other site 754035011827 TOBE domain; Region: TOBE_2; pfam08402 754035011828 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035011829 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754035011830 Walker A/P-loop; other site 754035011831 ATP binding site [chemical binding]; other site 754035011832 Q-loop/lid; other site 754035011833 ABC transporter signature motif; other site 754035011834 Walker B; other site 754035011835 D-loop; other site 754035011836 H-loop/switch region; other site 754035011837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035011838 dimer interface [polypeptide binding]; other site 754035011839 conserved gate region; other site 754035011840 putative PBP binding loops; other site 754035011841 ABC-ATPase subunit interface; other site 754035011842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035011843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035011844 dimer interface [polypeptide binding]; other site 754035011845 conserved gate region; other site 754035011846 putative PBP binding loops; other site 754035011847 ABC-ATPase subunit interface; other site 754035011848 Predicted small integral membrane protein [Function unknown]; Region: COG5477 754035011849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035011850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035011851 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 754035011852 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 754035011853 N- and C-terminal domain interface [polypeptide binding]; other site 754035011854 active site 754035011855 MgATP binding site [chemical binding]; other site 754035011856 catalytic site [active] 754035011857 metal binding site [ion binding]; metal-binding site 754035011858 glycerol binding site [chemical binding]; other site 754035011859 homotetramer interface [polypeptide binding]; other site 754035011860 homodimer interface [polypeptide binding]; other site 754035011861 FBP binding site [chemical binding]; other site 754035011862 protein IIAGlc interface [polypeptide binding]; other site 754035011863 BA14K-like protein; Region: BA14K; pfam07886 754035011864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035011865 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 754035011866 putative ADP-binding pocket [chemical binding]; other site 754035011867 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 754035011868 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 754035011869 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 754035011870 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 754035011871 active site 754035011872 homotetramer interface [polypeptide binding]; other site 754035011873 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 754035011874 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 754035011875 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 754035011876 DNA protecting protein DprA; Region: dprA; TIGR00732 754035011877 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 754035011878 dihydroorotase; Validated; Region: PRK09059 754035011879 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035011880 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 754035011881 active site 754035011882 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 754035011883 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754035011884 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754035011885 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 754035011886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035011887 FAD binding site [chemical binding]; other site 754035011888 substrate binding site [chemical binding]; other site 754035011889 catalytic residues [active] 754035011890 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 754035011891 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754035011892 metal-dependent hydrolase; Provisional; Region: PRK00685 754035011893 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 754035011894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035011895 Coenzyme A binding pocket [chemical binding]; other site 754035011896 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 754035011897 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 754035011898 Uncharacterized conserved protein [Function unknown]; Region: COG1434 754035011899 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754035011900 putative active site [active] 754035011901 Predicted membrane protein [Function unknown]; Region: COG3821 754035011902 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 754035011903 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754035011904 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754035011905 Uncharacterized conserved protein [Function unknown]; Region: COG5458 754035011906 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035011907 HSP70 interaction site [polypeptide binding]; other site 754035011908 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754035011909 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 754035011910 Sporulation related domain; Region: SPOR; pfam05036 754035011911 Phasin protein; Region: Phasin_2; pfam09361 754035011912 Uncharacterized conserved protein [Function unknown]; Region: COG2127 754035011913 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 754035011914 Clp amino terminal domain; Region: Clp_N; pfam02861 754035011915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035011916 Walker A motif; other site 754035011917 ATP binding site [chemical binding]; other site 754035011918 Walker B motif; other site 754035011919 arginine finger; other site 754035011920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035011921 Walker A motif; other site 754035011922 ATP binding site [chemical binding]; other site 754035011923 Walker B motif; other site 754035011924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754035011925 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 754035011926 P-loop motif; other site 754035011927 ATP binding site [chemical binding]; other site 754035011928 Chloramphenicol (Cm) binding site [chemical binding]; other site 754035011929 catalytic residue [active] 754035011930 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 754035011931 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 754035011932 HIT family signature motif; other site 754035011933 catalytic residue [active] 754035011934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 754035011935 Protein of unknown function, DUF482; Region: DUF482; pfam04339 754035011936 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 754035011937 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 754035011938 putative active site [active] 754035011939 catalytic site [active] 754035011940 putative metal binding site [ion binding]; other site 754035011941 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 754035011942 homotrimer interaction site [polypeptide binding]; other site 754035011943 putative active site [active] 754035011944 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 754035011945 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 754035011946 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035011947 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 754035011948 rRNA interaction site [nucleotide binding]; other site 754035011949 S8 interaction site; other site 754035011950 putative laminin-1 binding site; other site 754035011951 elongation factor Ts; Provisional; Region: tsf; PRK09377 754035011952 UBA/TS-N domain; Region: UBA; pfam00627 754035011953 Elongation factor TS; Region: EF_TS; pfam00889 754035011954 Elongation factor TS; Region: EF_TS; pfam00889 754035011955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035011956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035011957 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035011958 putative effector binding pocket; other site 754035011959 putative dimerization interface [polypeptide binding]; other site 754035011960 SnoaL-like domain; Region: SnoaL_4; pfam13577 754035011961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035011962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035011963 active site 754035011964 catalytic tetrad [active] 754035011965 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 754035011966 putative nucleotide binding site [chemical binding]; other site 754035011967 uridine monophosphate binding site [chemical binding]; other site 754035011968 homohexameric interface [polypeptide binding]; other site 754035011969 ribosome recycling factor; Reviewed; Region: frr; PRK00083 754035011970 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 754035011971 hinge region; other site 754035011972 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 754035011973 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 754035011974 catalytic residue [active] 754035011975 putative FPP diphosphate binding site; other site 754035011976 putative FPP binding hydrophobic cleft; other site 754035011977 dimer interface [polypeptide binding]; other site 754035011978 putative IPP diphosphate binding site; other site 754035011979 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 754035011980 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 754035011981 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 754035011982 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 754035011983 active site 754035011984 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 754035011985 protein binding site [polypeptide binding]; other site 754035011986 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 754035011987 putative substrate binding region [chemical binding]; other site 754035011988 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 754035011989 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 754035011990 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754035011991 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754035011992 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754035011993 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754035011994 Surface antigen; Region: Bac_surface_Ag; pfam01103 754035011995 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 754035011996 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 754035011997 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 754035011998 trimer interface [polypeptide binding]; other site 754035011999 active site 754035012000 UDP-GlcNAc binding site [chemical binding]; other site 754035012001 lipid binding site [chemical binding]; lipid-binding site 754035012002 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 754035012003 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 754035012004 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 754035012005 active site 754035012006 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 754035012007 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 754035012008 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 754035012009 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 754035012010 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 754035012011 dimer interface [polypeptide binding]; other site 754035012012 active site 754035012013 citrylCoA binding site [chemical binding]; other site 754035012014 NADH binding [chemical binding]; other site 754035012015 cationic pore residues; other site 754035012016 oxalacetate/citrate binding site [chemical binding]; other site 754035012017 coenzyme A binding site [chemical binding]; other site 754035012018 catalytic triad [active] 754035012019 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 754035012020 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754035012021 active site 754035012022 HIGH motif; other site 754035012023 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754035012024 active site 754035012025 KMSKS motif; other site 754035012026 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 754035012027 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 754035012028 Competence protein; Region: Competence; pfam03772 754035012029 LexA repressor; Validated; Region: PRK00215 754035012030 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 754035012031 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754035012032 Catalytic site [active] 754035012033 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035012034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035012035 DNA-binding site [nucleotide binding]; DNA binding site 754035012036 FCD domain; Region: FCD; pfam07729 754035012037 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 754035012038 zinc binding site [ion binding]; other site 754035012039 putative ligand binding site [chemical binding]; other site 754035012040 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 754035012041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035012042 Walker A/P-loop; other site 754035012043 ATP binding site [chemical binding]; other site 754035012044 Q-loop/lid; other site 754035012045 ABC transporter signature motif; other site 754035012046 Walker B; other site 754035012047 D-loop; other site 754035012048 H-loop/switch region; other site 754035012049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035012050 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 754035012051 TM-ABC transporter signature motif; other site 754035012052 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 754035012053 kynureninase; Region: kynureninase; TIGR01814 754035012054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035012055 catalytic residue [active] 754035012056 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 754035012057 2-aminobenzoate-CoA ligase (ABCL); Region: ABCL; cd05958 754035012058 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 754035012059 putative dimer interface [polypeptide binding]; other site 754035012060 acyl-activating enzyme (AAE) consensus motif; other site 754035012061 putative active site [active] 754035012062 putative AMP binding site [chemical binding]; other site 754035012063 putative CoA binding site [chemical binding]; other site 754035012064 putative chemical substrate binding site [chemical binding]; other site 754035012065 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754035012066 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 754035012067 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 754035012068 dimer interface [polypeptide binding]; other site 754035012069 putative functional site; other site 754035012070 putative MPT binding site; other site 754035012071 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 754035012072 trimer interface [polypeptide binding]; other site 754035012073 dimer interface [polypeptide binding]; other site 754035012074 putative active site [active] 754035012075 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 754035012076 active site 754035012077 ribulose/triose binding site [chemical binding]; other site 754035012078 phosphate binding site [ion binding]; other site 754035012079 substrate (anthranilate) binding pocket [chemical binding]; other site 754035012080 product (indole) binding pocket [chemical binding]; other site 754035012081 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 754035012082 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754035012083 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754035012084 SurA N-terminal domain; Region: SurA_N_3; cl07813 754035012085 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 754035012086 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754035012087 triosephosphate isomerase; Provisional; Region: PRK14565 754035012088 substrate binding site [chemical binding]; other site 754035012089 dimer interface [polypeptide binding]; other site 754035012090 catalytic triad [active] 754035012091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035012092 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035012093 CTP synthetase; Validated; Region: pyrG; PRK05380 754035012094 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 754035012095 Catalytic site [active] 754035012096 active site 754035012097 UTP binding site [chemical binding]; other site 754035012098 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 754035012099 active site 754035012100 putative oxyanion hole; other site 754035012101 catalytic triad [active] 754035012102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 754035012103 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 754035012104 Na binding site [ion binding]; other site 754035012105 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035012106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035012107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035012108 dimerization interface [polypeptide binding]; other site 754035012109 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 754035012110 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754035012111 interface (dimer of trimers) [polypeptide binding]; other site 754035012112 Substrate-binding/catalytic site; other site 754035012113 Zn-binding sites [ion binding]; other site 754035012114 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 754035012115 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035012116 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 754035012117 peptide binding site [polypeptide binding]; other site 754035012118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035012119 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754035012120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012121 dimer interface [polypeptide binding]; other site 754035012122 conserved gate region; other site 754035012123 putative PBP binding loops; other site 754035012124 ABC-ATPase subunit interface; other site 754035012125 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035012126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012127 putative PBP binding loops; other site 754035012128 dimer interface [polypeptide binding]; other site 754035012129 ABC-ATPase subunit interface; other site 754035012130 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 754035012131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035012132 Walker A/P-loop; other site 754035012133 ATP binding site [chemical binding]; other site 754035012134 Q-loop/lid; other site 754035012135 ABC transporter signature motif; other site 754035012136 Walker B; other site 754035012137 D-loop; other site 754035012138 H-loop/switch region; other site 754035012139 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035012140 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 754035012141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035012142 Walker A/P-loop; other site 754035012143 ATP binding site [chemical binding]; other site 754035012144 Q-loop/lid; other site 754035012145 ABC transporter signature motif; other site 754035012146 Walker B; other site 754035012147 D-loop; other site 754035012148 H-loop/switch region; other site 754035012149 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754035012150 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035012151 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754035012152 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035012153 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035012154 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 754035012155 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 754035012156 Walker A/P-loop; other site 754035012157 ATP binding site [chemical binding]; other site 754035012158 Q-loop/lid; other site 754035012159 ABC transporter signature motif; other site 754035012160 Walker B; other site 754035012161 D-loop; other site 754035012162 H-loop/switch region; other site 754035012163 Cytochrome c; Region: Cytochrom_C; cl11414 754035012164 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 754035012165 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 754035012166 Subunit I/III interface [polypeptide binding]; other site 754035012167 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 754035012168 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 754035012169 D-pathway; other site 754035012170 Putative ubiquinol binding site [chemical binding]; other site 754035012171 Low-spin heme (heme b) binding site [chemical binding]; other site 754035012172 Putative water exit pathway; other site 754035012173 Binuclear center (heme o3/CuB) [ion binding]; other site 754035012174 K-pathway; other site 754035012175 Putative proton exit pathway; other site 754035012176 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 754035012177 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 754035012178 Cytochrome c; Region: Cytochrom_C; pfam00034 754035012179 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 754035012180 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 754035012181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035012182 substrate binding pocket [chemical binding]; other site 754035012183 membrane-bound complex binding site; other site 754035012184 hinge residues; other site 754035012185 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 754035012186 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 754035012187 Trp docking motif [polypeptide binding]; other site 754035012188 dimer interface [polypeptide binding]; other site 754035012189 active site 754035012190 small subunit binding site [polypeptide binding]; other site 754035012191 Domain of unknown function (DUF336); Region: DUF336; cl01249 754035012192 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 754035012193 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754035012194 FMN binding site [chemical binding]; other site 754035012195 active site 754035012196 catalytic residues [active] 754035012197 substrate binding site [chemical binding]; other site 754035012198 Predicted aspartyl protease [General function prediction only]; Region: COG3577 754035012199 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 754035012200 catalytic motif [active] 754035012201 Catalytic residue [active] 754035012202 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 754035012203 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 754035012204 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 754035012205 putative dimer interface [polypeptide binding]; other site 754035012206 active site pocket [active] 754035012207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035012208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035012209 dimer interface [polypeptide binding]; other site 754035012210 phosphorylation site [posttranslational modification] 754035012211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035012212 ATP binding site [chemical binding]; other site 754035012213 Mg2+ binding site [ion binding]; other site 754035012214 G-X-G motif; other site 754035012215 Staphylococcal nuclease homologues; Region: SNc; smart00318 754035012216 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 754035012217 Catalytic site; other site 754035012218 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035012219 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 754035012220 putative C-terminal domain interface [polypeptide binding]; other site 754035012221 putative GSH binding site (G-site) [chemical binding]; other site 754035012222 putative dimer interface [polypeptide binding]; other site 754035012223 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 754035012224 putative N-terminal domain interface [polypeptide binding]; other site 754035012225 putative dimer interface [polypeptide binding]; other site 754035012226 putative substrate binding pocket (H-site) [chemical binding]; other site 754035012227 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 754035012228 putative uracil binding site [chemical binding]; other site 754035012229 putative active site [active] 754035012230 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035012231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035012232 putative DNA binding site [nucleotide binding]; other site 754035012233 putative Zn2+ binding site [ion binding]; other site 754035012234 AsnC family; Region: AsnC_trans_reg; pfam01037 754035012235 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 754035012236 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 754035012237 A new structural DNA glycosylase; Region: AlkD_like; cd06561 754035012238 active site 754035012239 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 754035012240 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035012241 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035012242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012243 dimer interface [polypeptide binding]; other site 754035012244 conserved gate region; other site 754035012245 putative PBP binding loops; other site 754035012246 ABC-ATPase subunit interface; other site 754035012247 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035012248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012249 dimer interface [polypeptide binding]; other site 754035012250 conserved gate region; other site 754035012251 putative PBP binding loops; other site 754035012252 ABC-ATPase subunit interface; other site 754035012253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035012254 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035012255 substrate binding pocket [chemical binding]; other site 754035012256 membrane-bound complex binding site; other site 754035012257 hinge residues; other site 754035012258 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 754035012259 Walker A motif; other site 754035012260 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 754035012261 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 754035012262 GTP binding site; other site 754035012263 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035012264 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 754035012265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035012266 FeS/SAM binding site; other site 754035012267 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 754035012268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 754035012269 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 754035012270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035012271 MarR family; Region: MarR_2; pfam12802 754035012272 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754035012273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035012274 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 754035012275 active site 754035012276 catalytic residue [active] 754035012277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035012278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035012279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754035012280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035012281 NAD(P) binding site [chemical binding]; other site 754035012282 active site 754035012283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 754035012284 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035012285 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 754035012286 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 754035012287 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 754035012288 phosphoglycolate phosphatase; Provisional; Region: PRK13222 754035012289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035012290 motif II; other site 754035012291 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 754035012292 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754035012293 active site 754035012294 dimer interface [polypeptide binding]; other site 754035012295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 754035012296 glutathione reductase; Validated; Region: PRK06116 754035012297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035012298 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035012299 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 754035012300 MgtE intracellular N domain; Region: MgtE_N; pfam03448 754035012301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 754035012302 Divalent cation transporter; Region: MgtE; pfam01769 754035012303 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 754035012304 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 754035012305 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 754035012306 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 754035012307 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 754035012308 catalytic residues [active] 754035012309 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754035012310 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 754035012311 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 754035012312 Uncharacterized conserved protein [Function unknown]; Region: COG3785 754035012313 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 754035012314 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035012315 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 754035012316 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 754035012317 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 754035012318 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 754035012319 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 754035012320 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 754035012321 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 754035012322 NADP binding site [chemical binding]; other site 754035012323 dimer interface [polypeptide binding]; other site 754035012324 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 754035012325 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035012326 Walker A/P-loop; other site 754035012327 ATP binding site [chemical binding]; other site 754035012328 Q-loop/lid; other site 754035012329 ABC transporter signature motif; other site 754035012330 Walker B; other site 754035012331 D-loop; other site 754035012332 H-loop/switch region; other site 754035012333 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035012334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035012335 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035012336 TM-ABC transporter signature motif; other site 754035012337 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 754035012338 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035012339 TM-ABC transporter signature motif; other site 754035012340 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754035012341 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 754035012342 putative ligand binding site [chemical binding]; other site 754035012343 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 754035012344 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754035012345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035012346 FeS/SAM binding site; other site 754035012347 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 754035012348 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 754035012349 Uncharacterized conserved protein [Function unknown]; Region: COG5482 754035012350 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 754035012351 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 754035012352 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 754035012353 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 754035012354 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 754035012355 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754035012356 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 754035012357 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 754035012358 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 754035012359 TMP-binding site; other site 754035012360 ATP-binding site [chemical binding]; other site 754035012361 DNA polymerase III subunit delta'; Validated; Region: PRK09112 754035012362 DNA polymerase III subunit delta'; Validated; Region: PRK08485 754035012363 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 754035012364 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 754035012365 active site 754035012366 HIGH motif; other site 754035012367 KMSKS motif; other site 754035012368 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 754035012369 tRNA binding surface [nucleotide binding]; other site 754035012370 anticodon binding site; other site 754035012371 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 754035012372 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754035012373 active site 754035012374 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 754035012375 putative hydrolase; Provisional; Region: PRK02113 754035012376 agmatinase; Region: agmatinase; TIGR01230 754035012377 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 754035012378 oligomer interface [polypeptide binding]; other site 754035012379 active site 754035012380 Mn binding site [ion binding]; other site 754035012381 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 754035012382 active site 754035012383 catalytic residues [active] 754035012384 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 754035012385 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 754035012386 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 754035012387 RNA polymerase sigma factor; Provisional; Region: PRK12511 754035012388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035012389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035012390 DNA binding residues [nucleotide binding] 754035012391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035012392 catalytic core [active] 754035012393 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 754035012394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035012395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035012396 homodimer interface [polypeptide binding]; other site 754035012397 catalytic residue [active] 754035012398 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 754035012399 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 754035012400 homodimer interface [polypeptide binding]; other site 754035012401 metal binding site [ion binding]; metal-binding site 754035012402 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 754035012403 homodimer interface [polypeptide binding]; other site 754035012404 active site 754035012405 putative chemical substrate binding site [chemical binding]; other site 754035012406 metal binding site [ion binding]; metal-binding site 754035012407 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 754035012408 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 754035012409 HflX GTPase family; Region: HflX; cd01878 754035012410 G1 box; other site 754035012411 GTP/Mg2+ binding site [chemical binding]; other site 754035012412 Switch I region; other site 754035012413 G2 box; other site 754035012414 G3 box; other site 754035012415 Switch II region; other site 754035012416 G4 box; other site 754035012417 G5 box; other site 754035012418 bacterial Hfq-like; Region: Hfq; cd01716 754035012419 hexamer interface [polypeptide binding]; other site 754035012420 Sm1 motif; other site 754035012421 RNA binding site [nucleotide binding]; other site 754035012422 Sm2 motif; other site 754035012423 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754035012424 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 754035012425 homodimer interface [polypeptide binding]; other site 754035012426 substrate-cofactor binding pocket; other site 754035012427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035012428 catalytic residue [active] 754035012429 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 754035012430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035012431 active site 754035012432 phosphorylation site [posttranslational modification] 754035012433 intermolecular recognition site; other site 754035012434 dimerization interface [polypeptide binding]; other site 754035012435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035012436 Walker A motif; other site 754035012437 ATP binding site [chemical binding]; other site 754035012438 Walker B motif; other site 754035012439 arginine finger; other site 754035012440 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035012441 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 754035012442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035012443 dimerization interface [polypeptide binding]; other site 754035012444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 754035012445 putative active site [active] 754035012446 heme pocket [chemical binding]; other site 754035012447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035012448 dimer interface [polypeptide binding]; other site 754035012449 phosphorylation site [posttranslational modification] 754035012450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035012451 ATP binding site [chemical binding]; other site 754035012452 Mg2+ binding site [ion binding]; other site 754035012453 G-X-G motif; other site 754035012454 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 754035012455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035012456 active site 754035012457 phosphorylation site [posttranslational modification] 754035012458 intermolecular recognition site; other site 754035012459 dimerization interface [polypeptide binding]; other site 754035012460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035012461 Walker A motif; other site 754035012462 ATP binding site [chemical binding]; other site 754035012463 Walker B motif; other site 754035012464 arginine finger; other site 754035012465 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 754035012466 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 754035012467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035012468 dimer interface [polypeptide binding]; other site 754035012469 phosphorylation site [posttranslational modification] 754035012470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035012471 ATP binding site [chemical binding]; other site 754035012472 Mg2+ binding site [ion binding]; other site 754035012473 G-X-G motif; other site 754035012474 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 754035012475 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754035012476 FMN binding site [chemical binding]; other site 754035012477 active site 754035012478 catalytic residues [active] 754035012479 substrate binding site [chemical binding]; other site 754035012480 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 754035012481 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 754035012482 substrate binding site; other site 754035012483 dimer interface; other site 754035012484 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 754035012485 homotrimer interaction site [polypeptide binding]; other site 754035012486 zinc binding site [ion binding]; other site 754035012487 CDP-binding sites; other site 754035012488 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 754035012489 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 754035012490 putative coenzyme Q binding site [chemical binding]; other site 754035012491 lipoyl synthase; Provisional; Region: PRK05481 754035012492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035012493 FeS/SAM binding site; other site 754035012494 Predicted membrane protein [Function unknown]; Region: COG2261 754035012495 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 754035012496 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 754035012497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035012498 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035012499 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 754035012500 active site 754035012501 catalytic triad [active] 754035012502 oxyanion hole [active] 754035012503 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035012504 E3 interaction surface; other site 754035012505 lipoyl attachment site [posttranslational modification]; other site 754035012506 e3 binding domain; Region: E3_binding; pfam02817 754035012507 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 754035012508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754035012509 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 754035012510 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754035012511 E3 interaction surface; other site 754035012512 lipoyl attachment site [posttranslational modification]; other site 754035012513 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 754035012514 alpha subunit interface [polypeptide binding]; other site 754035012515 TPP binding site [chemical binding]; other site 754035012516 heterodimer interface [polypeptide binding]; other site 754035012517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754035012518 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 754035012519 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 754035012520 tetramer interface [polypeptide binding]; other site 754035012521 TPP-binding site [chemical binding]; other site 754035012522 heterodimer interface [polypeptide binding]; other site 754035012523 phosphorylation loop region [posttranslational modification] 754035012524 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 754035012525 Septum formation initiator; Region: DivIC; pfam04977 754035012526 enolase; Provisional; Region: eno; PRK00077 754035012527 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 754035012528 dimer interface [polypeptide binding]; other site 754035012529 metal binding site [ion binding]; metal-binding site 754035012530 substrate binding pocket [chemical binding]; other site 754035012531 PRC-barrel domain; Region: PRC; pfam05239 754035012532 Dodecin; Region: Dodecin; pfam07311 754035012533 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 754035012534 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754035012535 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 754035012536 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 754035012537 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 754035012538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035012539 S-adenosylmethionine binding site [chemical binding]; other site 754035012540 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 754035012541 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 754035012542 active site 754035012543 metal binding site [ion binding]; metal-binding site 754035012544 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754035012545 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 754035012546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035012547 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 754035012548 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 754035012549 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035012550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035012551 putative DNA binding site [nucleotide binding]; other site 754035012552 putative Zn2+ binding site [ion binding]; other site 754035012553 AsnC family; Region: AsnC_trans_reg; pfam01037 754035012554 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 754035012555 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 754035012556 hexamer interface [polypeptide binding]; other site 754035012557 ligand binding site [chemical binding]; other site 754035012558 putative active site [active] 754035012559 NAD(P) binding site [chemical binding]; other site 754035012560 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 754035012561 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035012562 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 754035012563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035012564 Coenzyme A binding pocket [chemical binding]; other site 754035012565 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 754035012566 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 754035012567 active site residue [active] 754035012568 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 754035012569 active site residue [active] 754035012570 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 754035012571 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754035012572 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754035012573 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754035012574 dimer interface [polypeptide binding]; other site 754035012575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035012576 catalytic residue [active] 754035012577 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 754035012578 short chain dehydrogenase; Provisional; Region: PRK07024 754035012579 putative NAD(P) binding site [chemical binding]; other site 754035012580 active site 754035012581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035012582 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 754035012583 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754035012584 ATP binding site [chemical binding]; other site 754035012585 Mg++ binding site [ion binding]; other site 754035012586 motif III; other site 754035012587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035012588 nucleotide binding region [chemical binding]; other site 754035012589 ATP-binding site [chemical binding]; other site 754035012590 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 754035012591 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754035012592 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 754035012593 Uncharacterized conserved protein [Function unknown]; Region: COG0062 754035012594 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 754035012595 putative substrate binding site [chemical binding]; other site 754035012596 putative ATP binding site [chemical binding]; other site 754035012597 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 754035012598 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754035012599 glutamine synthetase; Provisional; Region: glnA; PRK09469 754035012600 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754035012601 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035012602 glutamine synthetase; Region: PLN02284 754035012603 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754035012604 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035012605 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 754035012606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035012607 putative substrate translocation pore; other site 754035012608 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 754035012609 EamA-like transporter family; Region: EamA; pfam00892 754035012610 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754035012611 EamA-like transporter family; Region: EamA; pfam00892 754035012612 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754035012613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035012614 RNA binding surface [nucleotide binding]; other site 754035012615 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754035012616 active site 754035012617 camphor resistance protein CrcB; Provisional; Region: PRK14195 754035012618 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 754035012619 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 754035012620 recombination factor protein RarA; Reviewed; Region: PRK13342 754035012621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035012622 Walker A motif; other site 754035012623 ATP binding site [chemical binding]; other site 754035012624 Walker B motif; other site 754035012625 arginine finger; other site 754035012626 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 754035012627 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 754035012628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035012629 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035012630 protein binding site [polypeptide binding]; other site 754035012631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035012632 protein binding site [polypeptide binding]; other site 754035012633 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 754035012634 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 754035012635 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 754035012636 alphaNTD homodimer interface [polypeptide binding]; other site 754035012637 alphaNTD - beta interaction site [polypeptide binding]; other site 754035012638 alphaNTD - beta' interaction site [polypeptide binding]; other site 754035012639 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 754035012640 30S ribosomal protein S11; Validated; Region: PRK05309 754035012641 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 754035012642 30S ribosomal protein S13; Region: bact_S13; TIGR03631 754035012643 adenylate kinase; Reviewed; Region: adk; PRK00279 754035012644 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 754035012645 AMP-binding site [chemical binding]; other site 754035012646 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 754035012647 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 754035012648 SecY translocase; Region: SecY; pfam00344 754035012649 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 754035012650 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 754035012651 23S rRNA binding site [nucleotide binding]; other site 754035012652 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 754035012653 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 754035012654 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 754035012655 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 754035012656 23S rRNA interface [nucleotide binding]; other site 754035012657 5S rRNA interface [nucleotide binding]; other site 754035012658 L27 interface [polypeptide binding]; other site 754035012659 L5 interface [polypeptide binding]; other site 754035012660 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 754035012661 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754035012662 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754035012663 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 754035012664 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 754035012665 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 754035012666 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 754035012667 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 754035012668 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 754035012669 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 754035012670 RNA binding site [nucleotide binding]; other site 754035012671 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 754035012672 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 754035012673 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 754035012674 putative translocon interaction site; other site 754035012675 23S rRNA interface [nucleotide binding]; other site 754035012676 signal recognition particle (SRP54) interaction site; other site 754035012677 L23 interface [polypeptide binding]; other site 754035012678 trigger factor interaction site; other site 754035012679 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 754035012680 23S rRNA interface [nucleotide binding]; other site 754035012681 5S rRNA interface [nucleotide binding]; other site 754035012682 putative antibiotic binding site [chemical binding]; other site 754035012683 L25 interface [polypeptide binding]; other site 754035012684 L27 interface [polypeptide binding]; other site 754035012685 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 754035012686 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 754035012687 G-X-X-G motif; other site 754035012688 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 754035012689 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 754035012690 putative translocon binding site; other site 754035012691 protein-rRNA interface [nucleotide binding]; other site 754035012692 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 754035012693 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 754035012694 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 754035012695 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 754035012696 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 754035012697 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 754035012698 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 754035012699 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 754035012700 elongation factor Tu; Reviewed; Region: PRK00049 754035012701 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754035012702 G1 box; other site 754035012703 GEF interaction site [polypeptide binding]; other site 754035012704 GTP/Mg2+ binding site [chemical binding]; other site 754035012705 Switch I region; other site 754035012706 G2 box; other site 754035012707 G3 box; other site 754035012708 Switch II region; other site 754035012709 G4 box; other site 754035012710 G5 box; other site 754035012711 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 754035012712 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754035012713 Antibiotic Binding Site [chemical binding]; other site 754035012714 elongation factor G; Reviewed; Region: PRK00007 754035012715 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 754035012716 G1 box; other site 754035012717 putative GEF interaction site [polypeptide binding]; other site 754035012718 GTP/Mg2+ binding site [chemical binding]; other site 754035012719 Switch I region; other site 754035012720 G2 box; other site 754035012721 G3 box; other site 754035012722 Switch II region; other site 754035012723 G4 box; other site 754035012724 G5 box; other site 754035012725 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754035012726 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754035012727 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 754035012728 30S ribosomal protein S7; Validated; Region: PRK05302 754035012729 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 754035012730 S17 interaction site [polypeptide binding]; other site 754035012731 S8 interaction site; other site 754035012732 16S rRNA interaction site [nucleotide binding]; other site 754035012733 streptomycin interaction site [chemical binding]; other site 754035012734 23S rRNA interaction site [nucleotide binding]; other site 754035012735 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 754035012736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035012737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035012738 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 754035012739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035012740 S-adenosylmethionine binding site [chemical binding]; other site 754035012741 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 754035012742 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 754035012743 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 754035012744 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 754035012745 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 754035012746 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754035012747 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 754035012748 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754035012749 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 754035012750 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 754035012751 DNA binding site [nucleotide binding] 754035012752 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 754035012753 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 754035012754 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 754035012755 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 754035012756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 754035012757 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 754035012758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 754035012759 RPB1 interaction site [polypeptide binding]; other site 754035012760 RPB11 interaction site [polypeptide binding]; other site 754035012761 RPB10 interaction site [polypeptide binding]; other site 754035012762 RPB3 interaction site [polypeptide binding]; other site 754035012763 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 754035012764 L11 interface [polypeptide binding]; other site 754035012765 putative EF-Tu interaction site [polypeptide binding]; other site 754035012766 putative EF-G interaction site [polypeptide binding]; other site 754035012767 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 754035012768 23S rRNA interface [nucleotide binding]; other site 754035012769 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 754035012770 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 754035012771 mRNA/rRNA interface [nucleotide binding]; other site 754035012772 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 754035012773 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 754035012774 23S rRNA interface [nucleotide binding]; other site 754035012775 L7/L12 interface [polypeptide binding]; other site 754035012776 putative thiostrepton binding site; other site 754035012777 L25 interface [polypeptide binding]; other site 754035012778 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 754035012779 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 754035012780 putative homodimer interface [polypeptide binding]; other site 754035012781 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 754035012782 heterodimer interface [polypeptide binding]; other site 754035012783 homodimer interface [polypeptide binding]; other site 754035012784 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 754035012785 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 754035012786 apolar tunnel; other site 754035012787 heme binding site [chemical binding]; other site 754035012788 dimerization interface [polypeptide binding]; other site 754035012789 Predicted periplasmic protein [Function unknown]; Region: COG3904 754035012790 Predicted periplasmic protein [Function unknown]; Region: COG3904 754035012791 elongation factor Tu; Reviewed; Region: PRK00049 754035012792 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754035012793 G1 box; other site 754035012794 GEF interaction site [polypeptide binding]; other site 754035012795 GTP/Mg2+ binding site [chemical binding]; other site 754035012796 Switch I region; other site 754035012797 G2 box; other site 754035012798 G3 box; other site 754035012799 Switch II region; other site 754035012800 G4 box; other site 754035012801 G5 box; other site 754035012802 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 754035012803 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754035012804 Antibiotic Binding Site [chemical binding]; other site 754035012805 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035012806 Predicted membrane protein [Function unknown]; Region: COG2261 754035012807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 754035012808 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754035012809 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 754035012810 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754035012811 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035012812 tartronate semialdehyde reductase; Provisional; Region: PRK15059 754035012813 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 754035012814 glyoxylate carboligase; Provisional; Region: PRK11269 754035012815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035012816 PYR/PP interface [polypeptide binding]; other site 754035012817 dimer interface [polypeptide binding]; other site 754035012818 TPP binding site [chemical binding]; other site 754035012819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035012820 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 754035012821 TPP-binding site [chemical binding]; other site 754035012822 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 754035012823 Transcriptional regulator [Transcription]; Region: IclR; COG1414 754035012824 Bacterial transcriptional regulator; Region: IclR; pfam01614 754035012825 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 754035012826 BA14K-like protein; Region: BA14K; pfam07886 754035012827 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 754035012828 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 754035012829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035012830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035012831 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035012832 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035012833 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035012834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012835 dimer interface [polypeptide binding]; other site 754035012836 conserved gate region; other site 754035012837 putative PBP binding loops; other site 754035012838 ABC-ATPase subunit interface; other site 754035012839 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035012840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035012841 dimer interface [polypeptide binding]; other site 754035012842 conserved gate region; other site 754035012843 putative PBP binding loops; other site 754035012844 ABC-ATPase subunit interface; other site 754035012845 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035012846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035012847 Walker A/P-loop; other site 754035012848 ATP binding site [chemical binding]; other site 754035012849 Q-loop/lid; other site 754035012850 ABC transporter signature motif; other site 754035012851 Walker B; other site 754035012852 D-loop; other site 754035012853 H-loop/switch region; other site 754035012854 TOBE domain; Region: TOBE_2; pfam08402 754035012855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754035012856 Protein of unknown function (DUF707); Region: DUF707; pfam05212 754035012857 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 754035012858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035012859 UDP-galactopyranose mutase; Region: GLF; pfam03275 754035012860 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 754035012861 ATP-NAD kinase; Region: NAD_kinase; pfam01513 754035012862 helicase 45; Provisional; Region: PTZ00424 754035012863 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754035012864 ATP binding site [chemical binding]; other site 754035012865 Mg++ binding site [ion binding]; other site 754035012866 motif III; other site 754035012867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035012868 nucleotide binding region [chemical binding]; other site 754035012869 ATP-binding site [chemical binding]; other site 754035012870 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 754035012871 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754035012872 ligand binding site [chemical binding]; other site 754035012873 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035012874 peptide chain release factor 2; Provisional; Region: PRK07342 754035012875 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754035012876 RF-1 domain; Region: RF-1; pfam00472 754035012877 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 754035012878 Transglycosylase; Region: Transgly; pfam00912 754035012879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754035012880 AMIN domain; Region: AMIN; pfam11741 754035012881 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 754035012882 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 754035012883 active site 754035012884 metal binding site [ion binding]; metal-binding site 754035012885 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754035012886 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754035012887 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 754035012888 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 754035012889 glutaminase; Provisional; Region: PRK00971 754035012890 aspartate aminotransferase; Provisional; Region: PRK05764 754035012891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035012892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035012893 homodimer interface [polypeptide binding]; other site 754035012894 catalytic residue [active] 754035012895 Peptidase family M48; Region: Peptidase_M48; cl12018 754035012896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035012897 binding surface 754035012898 TPR repeat; Region: TPR_11; pfam13414 754035012899 TPR motif; other site 754035012900 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 754035012901 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754035012902 catalytic residues [active] 754035012903 Dehydroquinase class II; Region: DHquinase_II; pfam01220 754035012904 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 754035012905 trimer interface [polypeptide binding]; other site 754035012906 active site 754035012907 dimer interface [polypeptide binding]; other site 754035012908 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 754035012909 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754035012910 carboxyltransferase (CT) interaction site; other site 754035012911 biotinylation site [posttranslational modification]; other site 754035012912 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 754035012913 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035012914 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035012915 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754035012916 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 754035012917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 754035012918 NADH dehydrogenase; Validated; Region: PRK08183 754035012919 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 754035012920 oligomerization interface [polypeptide binding]; other site 754035012921 active site 754035012922 metal binding site [ion binding]; metal-binding site 754035012923 Pantoate-beta-alanine ligase; Region: PanC; cd00560 754035012924 pantoate--beta-alanine ligase; Region: panC; TIGR00018 754035012925 active site 754035012926 ATP-binding site [chemical binding]; other site 754035012927 pantoate-binding site; other site 754035012928 HXXH motif; other site 754035012929 Uncharacterized conserved protein [Function unknown]; Region: COG2013 754035012930 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035012931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035012932 Coenzyme A binding pocket [chemical binding]; other site 754035012933 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 754035012934 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 754035012935 GatB domain; Region: GatB_Yqey; smart00845 754035012936 hypothetical protein; Provisional; Region: PRK13687 754035012937 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 754035012938 FOG: CBS domain [General function prediction only]; Region: COG0517 754035012939 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 754035012940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 754035012941 PAS domain; Region: PAS_5; pfam07310 754035012942 PilZ domain; Region: PilZ; pfam07238 754035012943 PilZ domain; Region: PilZ; pfam07238 754035012944 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 754035012945 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 754035012946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 754035012947 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 754035012948 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 754035012949 trimer interface [polypeptide binding]; other site 754035012950 putative metal binding site [ion binding]; other site 754035012951 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 754035012952 serine acetyltransferase; Provisional; Region: cysE; PRK11132 754035012953 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 754035012954 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 754035012955 trimer interface [polypeptide binding]; other site 754035012956 active site 754035012957 substrate binding site [chemical binding]; other site 754035012958 CoA binding site [chemical binding]; other site 754035012959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 754035012960 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035012961 Uncharacterized conserved protein [Function unknown]; Region: COG1430 754035012962 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035012963 DNA-binding site [nucleotide binding]; DNA binding site 754035012964 RNA-binding motif; other site 754035012965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035012966 DNA-binding site [nucleotide binding]; DNA binding site 754035012967 RNA-binding motif; other site 754035012968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035012969 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 754035012970 dimer interface [polypeptide binding]; other site 754035012971 active site 754035012972 metal binding site [ion binding]; metal-binding site 754035012973 glutathione binding site [chemical binding]; other site 754035012974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 754035012975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 754035012976 threonine dehydratase; Validated; Region: PRK08639 754035012977 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754035012978 tetramer interface [polypeptide binding]; other site 754035012979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035012980 catalytic residue [active] 754035012981 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 754035012982 putative Ile/Val binding site [chemical binding]; other site 754035012983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 754035012984 Bor protein; Region: Lambda_Bor; pfam06291 754035012985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 754035012986 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 754035012987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035012988 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 754035012989 active site 754035012990 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 754035012991 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035012992 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 754035012993 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 754035012994 active site clefts [active] 754035012995 zinc binding site [ion binding]; other site 754035012996 dimer interface [polypeptide binding]; other site 754035012997 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035012998 HSP70 interaction site [polypeptide binding]; other site 754035012999 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 754035013000 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754035013001 dimer interface [polypeptide binding]; other site 754035013002 ADP-ribose binding site [chemical binding]; other site 754035013003 active site 754035013004 nudix motif; other site 754035013005 metal binding site [ion binding]; metal-binding site 754035013006 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 754035013007 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 754035013008 active site 754035013009 FMN binding site [chemical binding]; other site 754035013010 substrate binding site [chemical binding]; other site 754035013011 homotetramer interface [polypeptide binding]; other site 754035013012 catalytic residue [active] 754035013013 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035013014 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 754035013015 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 754035013016 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 754035013017 putative MPT binding site; other site 754035013018 Universal stress protein family; Region: Usp; pfam00582 754035013019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035013020 Ligand Binding Site [chemical binding]; other site 754035013021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035013022 active site 754035013023 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 754035013024 nudix motif; other site 754035013025 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 754035013026 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 754035013027 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 754035013028 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 754035013029 active site 754035013030 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 754035013031 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 754035013032 TSCPD domain; Region: TSCPD; pfam12637 754035013033 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 754035013034 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 754035013035 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 754035013036 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 754035013037 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 754035013038 active site 754035013039 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 754035013040 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754035013041 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754035013042 Predicted periplasmic protein [Function unknown]; Region: COG3698 754035013043 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 754035013044 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 754035013045 Bacitracin resistance protein BacA; Region: BacA; pfam02673 754035013046 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035013047 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 754035013048 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 754035013049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035013050 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754035013051 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 754035013052 putative hydrophobic ligand binding site [chemical binding]; other site 754035013053 ParB-like nuclease domain; Region: ParB; smart00470 754035013054 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 754035013055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035013056 inhibitor-cofactor binding pocket; inhibition site 754035013057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035013058 catalytic residue [active] 754035013059 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 754035013060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035013061 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035013062 Coenzyme A binding pocket [chemical binding]; other site 754035013063 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 754035013064 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 754035013065 active site 754035013066 Zn binding site [ion binding]; other site 754035013067 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754035013068 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 754035013069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035013070 catalytic residue [active] 754035013071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035013072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035013073 active site 754035013074 catalytic tetrad [active] 754035013075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 754035013076 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 754035013077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 754035013078 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 754035013079 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 754035013080 putative MPT binding site; other site 754035013081 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 754035013082 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 754035013083 Ligand binding site; other site 754035013084 metal-binding site 754035013085 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 754035013086 XdhC Rossmann domain; Region: XdhC_C; pfam13478 754035013087 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 754035013088 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 754035013089 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 754035013090 metal ion-dependent adhesion site (MIDAS); other site 754035013091 MoxR-like ATPases [General function prediction only]; Region: COG0714 754035013092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035013093 Walker A motif; other site 754035013094 ATP binding site [chemical binding]; other site 754035013095 Walker B motif; other site 754035013096 arginine finger; other site 754035013097 Flavin Reductases; Region: FlaRed; cl00801 754035013098 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035013099 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 754035013100 ligand binding site [chemical binding]; other site 754035013101 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 754035013102 putative active site pocket [active] 754035013103 cleavage site 754035013104 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 754035013105 cleavage site 754035013106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3798 754035013107 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 754035013108 adenylosuccinate lyase; Provisional; Region: PRK07492 754035013109 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 754035013110 tetramer interface [polypeptide binding]; other site 754035013111 active site 754035013112 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 754035013113 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 754035013114 putative metal binding site [ion binding]; other site 754035013115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 754035013116 active site 754035013117 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 754035013118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754035013119 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035013120 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 754035013121 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 754035013122 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 754035013123 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 754035013124 ATP binding site [chemical binding]; other site 754035013125 active site 754035013126 substrate binding site [chemical binding]; other site 754035013127 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 754035013128 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 754035013129 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 754035013130 putative active site [active] 754035013131 catalytic triad [active] 754035013132 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035013133 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754035013134 C-terminal domain interface [polypeptide binding]; other site 754035013135 GSH binding site (G-site) [chemical binding]; other site 754035013136 dimer interface [polypeptide binding]; other site 754035013137 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035013138 N-terminal domain interface [polypeptide binding]; other site 754035013139 dimer interface [polypeptide binding]; other site 754035013140 substrate binding pocket (H-site) [chemical binding]; other site 754035013141 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754035013142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035013143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035013144 DNA-binding site [nucleotide binding]; DNA binding site 754035013145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035013146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035013147 homodimer interface [polypeptide binding]; other site 754035013148 catalytic residue [active] 754035013149 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 754035013150 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 754035013151 dimerization interface [polypeptide binding]; other site 754035013152 ATP binding site [chemical binding]; other site 754035013153 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 754035013154 dimerization interface [polypeptide binding]; other site 754035013155 ATP binding site [chemical binding]; other site 754035013156 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 754035013157 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 754035013158 putative GSH binding site [chemical binding]; other site 754035013159 catalytic residues [active] 754035013160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013161 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 754035013162 putative substrate translocation pore; other site 754035013163 Gram-negative bacterial tonB protein; Region: TonB; cl10048 754035013164 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035013165 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 754035013166 active site 754035013167 putative lithium-binding site [ion binding]; other site 754035013168 substrate binding site [chemical binding]; other site 754035013169 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 754035013170 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 754035013171 Ligand Binding Site [chemical binding]; other site 754035013172 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 754035013173 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 754035013174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035013175 RNA binding surface [nucleotide binding]; other site 754035013176 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 754035013177 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 754035013178 RNB domain; Region: RNB; pfam00773 754035013179 glutamate racemase; Provisional; Region: PRK00865 754035013180 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 754035013181 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 754035013182 isocitrate dehydrogenase; Validated; Region: PRK08299 754035013183 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035013184 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 754035013185 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 754035013186 N-terminal domain interface [polypeptide binding]; other site 754035013187 dimer interface [polypeptide binding]; other site 754035013188 substrate binding pocket (H-site) [chemical binding]; other site 754035013189 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 754035013190 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 754035013191 motif 1; other site 754035013192 active site 754035013193 motif 2; other site 754035013194 motif 3; other site 754035013195 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754035013196 DHHA1 domain; Region: DHHA1; pfam02272 754035013197 recombinase A; Provisional; Region: recA; PRK09354 754035013198 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 754035013199 hexamer interface [polypeptide binding]; other site 754035013200 Walker A motif; other site 754035013201 ATP binding site [chemical binding]; other site 754035013202 Walker B motif; other site 754035013203 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035013204 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 754035013205 substrate binding site [chemical binding]; other site 754035013206 ATP binding site [chemical binding]; other site 754035013207 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 754035013208 TfoX N-terminal domain; Region: TfoX_N; pfam04993 754035013209 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035013210 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 754035013211 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 754035013212 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754035013213 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 754035013214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035013215 catalytic residue [active] 754035013216 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 754035013217 FeS assembly protein SufD; Region: sufD; TIGR01981 754035013218 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 754035013219 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 754035013220 Walker A/P-loop; other site 754035013221 ATP binding site [chemical binding]; other site 754035013222 Q-loop/lid; other site 754035013223 ABC transporter signature motif; other site 754035013224 Walker B; other site 754035013225 D-loop; other site 754035013226 H-loop/switch region; other site 754035013227 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 754035013228 putative ABC transporter; Region: ycf24; CHL00085 754035013229 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 754035013230 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 754035013231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035013232 catalytic residue [active] 754035013233 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 754035013234 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 754035013235 active site 754035013236 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 754035013237 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 754035013238 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 754035013239 active site 754035013240 HIGH motif; other site 754035013241 dimer interface [polypeptide binding]; other site 754035013242 KMSKS motif; other site 754035013243 Protein of unknown function; Region: DUF3971; pfam13116 754035013244 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754035013245 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754035013246 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 754035013247 catalytic triad [active] 754035013248 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 754035013249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035013250 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 754035013251 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 754035013252 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754035013253 Peptidase family M23; Region: Peptidase_M23; pfam01551 754035013254 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035013255 non-specific DNA interactions [nucleotide binding]; other site 754035013256 DNA binding site [nucleotide binding] 754035013257 sequence specific DNA binding site [nucleotide binding]; other site 754035013258 putative cAMP binding site [chemical binding]; other site 754035013259 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035013260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035013261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035013262 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 754035013263 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035013264 Walker A/P-loop; other site 754035013265 ATP binding site [chemical binding]; other site 754035013266 Q-loop/lid; other site 754035013267 ABC transporter signature motif; other site 754035013268 Walker B; other site 754035013269 D-loop; other site 754035013270 H-loop/switch region; other site 754035013271 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 754035013272 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035013273 ligand binding site [chemical binding]; other site 754035013274 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035013275 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035013276 TM-ABC transporter signature motif; other site 754035013277 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 754035013278 classical (c) SDRs; Region: SDR_c; cd05233 754035013279 NAD(P) binding site [chemical binding]; other site 754035013280 active site 754035013281 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035013282 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 754035013283 substrate binding site [chemical binding]; other site 754035013284 dimer interface [polypeptide binding]; other site 754035013285 ATP binding site [chemical binding]; other site 754035013286 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 754035013287 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035013288 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035013289 Walker A/P-loop; other site 754035013290 ATP binding site [chemical binding]; other site 754035013291 Q-loop/lid; other site 754035013292 ABC transporter signature motif; other site 754035013293 Walker B; other site 754035013294 D-loop; other site 754035013295 H-loop/switch region; other site 754035013296 TOBE domain; Region: TOBE_2; pfam08402 754035013297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035013298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035013299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035013300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013301 dimer interface [polypeptide binding]; other site 754035013302 ABC-ATPase subunit interface; other site 754035013303 putative PBP binding loops; other site 754035013304 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035013305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013306 dimer interface [polypeptide binding]; other site 754035013307 conserved gate region; other site 754035013308 putative PBP binding loops; other site 754035013309 ABC-ATPase subunit interface; other site 754035013310 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 754035013311 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 754035013312 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035013313 tetramer interface [polypeptide binding]; other site 754035013314 active site 754035013315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035013316 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035013317 active site 754035013318 catalytic tetrad [active] 754035013319 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754035013320 IHF dimer interface [polypeptide binding]; other site 754035013321 IHF - DNA interface [nucleotide binding]; other site 754035013322 Found in ATP-dependent protease La (LON); Region: LON; smart00464 754035013323 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 754035013324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035013325 Walker A motif; other site 754035013326 ATP binding site [chemical binding]; other site 754035013327 Walker B motif; other site 754035013328 arginine finger; other site 754035013329 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 754035013330 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 754035013331 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 754035013332 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 754035013333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035013334 Walker A motif; other site 754035013335 ATP binding site [chemical binding]; other site 754035013336 Walker B motif; other site 754035013337 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754035013338 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 754035013339 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754035013340 oligomer interface [polypeptide binding]; other site 754035013341 active site residues [active] 754035013342 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 754035013343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035013344 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035013345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754035013346 Cytochrome P450; Region: p450; cl12078 754035013347 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 754035013348 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 754035013349 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754035013350 homodimer interface [polypeptide binding]; other site 754035013351 substrate-cofactor binding pocket; other site 754035013352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035013353 catalytic residue [active] 754035013354 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 754035013355 Predicted ATPase [General function prediction only]; Region: COG3910 754035013356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 754035013357 Walker A/P-loop; other site 754035013358 ATP binding site [chemical binding]; other site 754035013359 Q-loop/lid; other site 754035013360 ABC transporter signature motif; other site 754035013361 Walker B; other site 754035013362 D-loop; other site 754035013363 H-loop/switch region; other site 754035013364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 754035013365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035013366 enoyl-CoA hydratase; Validated; Region: PRK08139 754035013367 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035013368 substrate binding site [chemical binding]; other site 754035013369 oxyanion hole (OAH) forming residues; other site 754035013370 trimer interface [polypeptide binding]; other site 754035013371 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754035013372 CoenzymeA binding site [chemical binding]; other site 754035013373 subunit interaction site [polypeptide binding]; other site 754035013374 PHB binding site; other site 754035013375 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 754035013376 23S rRNA interface [nucleotide binding]; other site 754035013377 L3 interface [polypeptide binding]; other site 754035013378 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 754035013379 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 754035013380 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 754035013381 putative active site [active] 754035013382 catalytic site [active] 754035013383 putative metal binding site [ion binding]; other site 754035013384 oligomer interface [polypeptide binding]; other site 754035013385 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035013386 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 754035013387 agmatinase; Region: agmatinase; TIGR01230 754035013388 oligomer interface [polypeptide binding]; other site 754035013389 putative active site [active] 754035013390 Mn binding site [ion binding]; other site 754035013391 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 754035013392 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754035013393 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 754035013394 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 754035013395 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 754035013396 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 754035013397 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 754035013398 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 754035013399 putative active site [active] 754035013400 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 754035013401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035013402 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 754035013403 Chain length determinant protein; Region: Wzz; pfam02706 754035013404 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 754035013405 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 754035013406 SLBB domain; Region: SLBB; pfam10531 754035013407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035013408 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754035013409 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 754035013410 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 754035013411 O-Antigen ligase; Region: Wzy_C; pfam04932 754035013412 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 754035013413 putative deacylase active site [active] 754035013414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035013415 non-specific DNA binding site [nucleotide binding]; other site 754035013416 salt bridge; other site 754035013417 sequence-specific DNA binding site [nucleotide binding]; other site 754035013418 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035013419 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 754035013420 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754035013421 DNA binding residues [nucleotide binding] 754035013422 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754035013423 IHF dimer interface [polypeptide binding]; other site 754035013424 IHF - DNA interface [nucleotide binding]; other site 754035013425 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 754035013426 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754035013427 dimer interface [polypeptide binding]; other site 754035013428 active site 754035013429 CoA binding pocket [chemical binding]; other site 754035013430 putative phosphate acyltransferase; Provisional; Region: PRK05331 754035013431 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 754035013432 Uncharacterized conserved protein [Function unknown]; Region: COG5452 754035013433 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 754035013434 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 754035013435 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 754035013436 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754035013437 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754035013438 active site 754035013439 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 754035013440 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 754035013441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013442 putative PBP binding loops; other site 754035013443 dimer interface [polypeptide binding]; other site 754035013444 ABC-ATPase subunit interface; other site 754035013445 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 754035013446 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 754035013447 Walker A/P-loop; other site 754035013448 ATP binding site [chemical binding]; other site 754035013449 Q-loop/lid; other site 754035013450 ABC transporter signature motif; other site 754035013451 Walker B; other site 754035013452 D-loop; other site 754035013453 H-loop/switch region; other site 754035013454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013455 dimer interface [polypeptide binding]; other site 754035013456 conserved gate region; other site 754035013457 ABC-ATPase subunit interface; other site 754035013458 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 754035013459 Predicted flavoprotein [General function prediction only]; Region: COG0431 754035013460 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035013461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035013463 putative substrate translocation pore; other site 754035013464 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 754035013465 putative RNA binding site [nucleotide binding]; other site 754035013466 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 754035013467 homopentamer interface [polypeptide binding]; other site 754035013468 active site 754035013469 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 754035013470 Lumazine binding domain; Region: Lum_binding; pfam00677 754035013471 Lumazine binding domain; Region: Lum_binding; pfam00677 754035013472 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 754035013473 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 754035013474 catalytic motif [active] 754035013475 Zn binding site [ion binding]; other site 754035013476 RibD C-terminal domain; Region: RibD_C; cl17279 754035013477 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 754035013478 ATP cone domain; Region: ATP-cone; pfam03477 754035013479 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 754035013480 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 754035013481 dimer interface [polypeptide binding]; other site 754035013482 active site 754035013483 glycine-pyridoxal phosphate binding site [chemical binding]; other site 754035013484 folate binding site [chemical binding]; other site 754035013485 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 754035013486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 754035013487 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035013488 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035013489 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035013490 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035013491 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 754035013492 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 754035013493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035013494 substrate binding site [chemical binding]; other site 754035013495 oxyanion hole (OAH) forming residues; other site 754035013496 trimer interface [polypeptide binding]; other site 754035013497 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 754035013498 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 754035013499 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 754035013500 dimer interface [polypeptide binding]; other site 754035013501 allosteric magnesium binding site [ion binding]; other site 754035013502 active site 754035013503 aspartate-rich active site metal binding site; other site 754035013504 Schiff base residues; other site 754035013505 RibD C-terminal domain; Region: RibD_C; cl17279 754035013506 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754035013507 Uncharacterized conserved protein [Function unknown]; Region: COG2326 754035013508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035013509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035013510 active site 754035013511 catalytic tetrad [active] 754035013512 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 754035013513 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 754035013514 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035013515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035013516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035013517 DNA-binding site [nucleotide binding]; DNA binding site 754035013518 FCD domain; Region: FCD; pfam07729 754035013519 drug efflux system protein MdtG; Provisional; Region: PRK09874 754035013520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013521 putative substrate translocation pore; other site 754035013522 Protein of unknown function (DUF423); Region: DUF423; cl01008 754035013523 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035013524 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 754035013525 DNA binding site [nucleotide binding] 754035013526 domain linker motif; other site 754035013527 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 754035013528 putative dimerization interface [polypeptide binding]; other site 754035013529 putative ligand binding site [chemical binding]; other site 754035013530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 754035013531 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035013532 Predicted esterase [General function prediction only]; Region: COG0400 754035013533 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 754035013534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035013535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035013536 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754035013537 RDD family; Region: RDD; pfam06271 754035013538 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 754035013539 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 754035013540 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 754035013541 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035013542 EamA-like transporter family; Region: EamA; pfam00892 754035013543 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754035013544 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754035013545 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 754035013546 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754035013547 CAP-like domain; other site 754035013548 active site 754035013549 primary dimer interface [polypeptide binding]; other site 754035013550 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754035013551 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 754035013552 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 754035013553 dimer interface [polypeptide binding]; other site 754035013554 anticodon binding site; other site 754035013555 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 754035013556 homodimer interface [polypeptide binding]; other site 754035013557 motif 1; other site 754035013558 active site 754035013559 motif 2; other site 754035013560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035013561 active site 754035013562 motif 3; other site 754035013563 Avidin family; Region: Avidin; pfam01382 754035013564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013565 putative substrate translocation pore; other site 754035013566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035013567 ribonuclease D; Region: rnd; TIGR01388 754035013568 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 754035013569 catalytic site [active] 754035013570 putative active site [active] 754035013571 putative substrate binding site [chemical binding]; other site 754035013572 HRDC domain; Region: HRDC; cl02578 754035013573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 754035013574 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 754035013575 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754035013576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 754035013577 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 754035013578 active site 754035013579 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 754035013580 putative active site [active] 754035013581 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 754035013582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035013584 putative substrate translocation pore; other site 754035013585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013586 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 754035013587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035013588 S-adenosylmethionine binding site [chemical binding]; other site 754035013589 exopolyphosphatase; Region: exo_poly_only; TIGR03706 754035013590 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754035013591 Predicted integral membrane protein [Function unknown]; Region: COG0392 754035013592 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 754035013593 EF-hand domain pair; Region: EF_hand_5; pfam13499 754035013594 Ca2+ binding site [ion binding]; other site 754035013595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 754035013596 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 754035013597 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 754035013598 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 754035013599 dimer interface [polypeptide binding]; other site 754035013600 active site 754035013601 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035013602 substrate binding site [chemical binding]; other site 754035013603 catalytic residue [active] 754035013604 heme exporter protein CcmC; Region: ccmC; TIGR01191 754035013605 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 754035013606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035013607 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 754035013608 Walker A/P-loop; other site 754035013609 ATP binding site [chemical binding]; other site 754035013610 Q-loop/lid; other site 754035013611 ABC transporter signature motif; other site 754035013612 Walker B; other site 754035013613 D-loop; other site 754035013614 H-loop/switch region; other site 754035013615 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 754035013616 Putative glucoamylase; Region: Glycoamylase; pfam10091 754035013617 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 754035013618 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 754035013619 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 754035013620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 754035013621 urocanate hydratase; Provisional; Region: PRK05414 754035013622 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 754035013623 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 754035013624 active sites [active] 754035013625 tetramer interface [polypeptide binding]; other site 754035013626 imidazolonepropionase; Validated; Region: PRK09356 754035013627 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 754035013628 active site 754035013629 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 754035013630 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 754035013631 active site 754035013632 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 754035013633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035013634 DNA-binding site [nucleotide binding]; DNA binding site 754035013635 UTRA domain; Region: UTRA; pfam07702 754035013636 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 754035013637 homotrimer interaction site [polypeptide binding]; other site 754035013638 putative active site [active] 754035013639 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 754035013640 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754035013641 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754035013642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754035013643 ABC-ATPase subunit interface; other site 754035013644 dimer interface [polypeptide binding]; other site 754035013645 putative PBP binding regions; other site 754035013646 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 754035013647 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 754035013648 metal binding site [ion binding]; metal-binding site 754035013649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 754035013650 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035013651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035013652 putative DNA binding site [nucleotide binding]; other site 754035013653 putative Zn2+ binding site [ion binding]; other site 754035013654 AsnC family; Region: AsnC_trans_reg; pfam01037 754035013655 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 754035013656 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 754035013657 dimer interface [polypeptide binding]; other site 754035013658 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 754035013659 active site 754035013660 Fe binding site [ion binding]; other site 754035013661 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 754035013662 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 754035013663 putative active site [active] 754035013664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 754035013665 DinB superfamily; Region: DinB_2; pfam12867 754035013666 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 754035013667 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035013668 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 754035013669 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754035013670 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 754035013671 MarR family; Region: MarR_2; cl17246 754035013672 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035013673 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 754035013674 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035013675 NAD(P) binding site [chemical binding]; other site 754035013676 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754035013677 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754035013678 substrate-cofactor binding pocket; other site 754035013679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035013680 catalytic residue [active] 754035013681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035013682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035013683 metal binding site [ion binding]; metal-binding site 754035013684 active site 754035013685 I-site; other site 754035013686 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035013687 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035013688 MarR family; Region: MarR; pfam01047 754035013689 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 754035013690 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 754035013691 putative active site [active] 754035013692 putative FMN binding site [chemical binding]; other site 754035013693 putative substrate binding site [chemical binding]; other site 754035013694 putative catalytic residue [active] 754035013695 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 754035013696 SnoaL-like domain; Region: SnoaL_4; cl17707 754035013697 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035013698 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754035013699 metal binding site [ion binding]; metal-binding site 754035013700 substrate binding pocket [chemical binding]; other site 754035013701 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 754035013702 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754035013703 phosphate binding site [ion binding]; other site 754035013704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754035013705 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035013706 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035013707 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 754035013708 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 754035013709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035013710 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035013711 dimerization interface [polypeptide binding]; other site 754035013712 substrate binding pocket [chemical binding]; other site 754035013713 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 754035013714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035013715 ATP binding site [chemical binding]; other site 754035013716 Mg2+ binding site [ion binding]; other site 754035013717 G-X-G motif; other site 754035013718 DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119 754035013719 ATP binding site [chemical binding]; other site 754035013720 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 754035013721 EamA-like transporter family; Region: EamA; pfam00892 754035013722 EamA-like transporter family; Region: EamA; pfam00892 754035013723 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 754035013724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035013725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035013726 dimerization interface [polypeptide binding]; other site 754035013727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 754035013728 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 754035013729 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 754035013730 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 754035013731 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 754035013732 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 754035013733 putative acyl-acceptor binding pocket; other site 754035013734 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 754035013735 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 754035013736 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035013737 active site 754035013738 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 754035013739 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 754035013740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035013741 putative metal binding site [ion binding]; other site 754035013742 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 754035013743 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754035013744 motif 1; other site 754035013745 dimer interface [polypeptide binding]; other site 754035013746 active site 754035013747 motif 2; other site 754035013748 motif 3; other site 754035013749 elongation factor P; Validated; Region: PRK00529 754035013750 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754035013751 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754035013752 RNA binding site [nucleotide binding]; other site 754035013753 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754035013754 RNA binding site [nucleotide binding]; other site 754035013755 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 754035013756 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 754035013757 nucleophile elbow; other site 754035013758 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754035013759 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754035013760 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754035013761 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754035013762 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754035013763 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754035013764 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 754035013765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035013766 S-adenosylmethionine binding site [chemical binding]; other site 754035013767 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 754035013768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035013769 RNA binding surface [nucleotide binding]; other site 754035013770 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 754035013771 active site 754035013772 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754035013773 dimer interface [polypeptide binding]; other site 754035013774 catalytic motif [active] 754035013775 nucleoside/Zn binding site; other site 754035013776 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 754035013777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754035013778 active site 754035013779 HIGH motif; other site 754035013780 nucleotide binding site [chemical binding]; other site 754035013781 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 754035013782 active site 754035013783 KMSKS motif; other site 754035013784 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 754035013785 tRNA binding surface [nucleotide binding]; other site 754035013786 anticodon binding site; other site 754035013787 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 754035013788 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 754035013789 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 754035013790 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 754035013791 active site 754035013792 Riboflavin kinase; Region: Flavokinase; smart00904 754035013793 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 754035013794 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 754035013795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035013796 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035013797 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 754035013798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 754035013799 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035013800 Predicted integral membrane protein [Function unknown]; Region: COG5473 754035013801 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035013802 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 754035013803 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 754035013804 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 754035013805 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035013806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013807 putative substrate translocation pore; other site 754035013808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035013809 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 754035013810 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035013811 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035013812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754035013813 MarR family; Region: MarR_2; pfam12802 754035013814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035013815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035013816 DNA binding site [nucleotide binding] 754035013817 domain linker motif; other site 754035013818 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 754035013819 ligand binding site [chemical binding]; other site 754035013820 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035013821 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035013822 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035013823 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035013824 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 754035013825 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035013826 putative ligand binding site [chemical binding]; other site 754035013827 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035013828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035013829 Walker A/P-loop; other site 754035013830 ATP binding site [chemical binding]; other site 754035013831 Q-loop/lid; other site 754035013832 ABC transporter signature motif; other site 754035013833 Walker B; other site 754035013834 D-loop; other site 754035013835 H-loop/switch region; other site 754035013836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035013837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035013838 TM-ABC transporter signature motif; other site 754035013839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754035013840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 754035013841 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035013842 MarR family; Region: MarR_2; pfam12802 754035013843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035013844 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754035013845 Coenzyme A binding pocket [chemical binding]; other site 754035013846 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 754035013847 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 754035013848 dimer interface [polypeptide binding]; other site 754035013849 active site 754035013850 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035013851 substrate binding site [chemical binding]; other site 754035013852 catalytic residue [active] 754035013853 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 754035013854 FAD binding domain; Region: FAD_binding_4; pfam01565 754035013855 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 754035013856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035013857 Methyltransferase domain; Region: Methyltransf_11; pfam08241 754035013858 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754035013859 oligomerisation interface [polypeptide binding]; other site 754035013860 mobile loop; other site 754035013861 roof hairpin; other site 754035013862 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754035013863 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754035013864 ring oligomerisation interface [polypeptide binding]; other site 754035013865 ATP/Mg binding site [chemical binding]; other site 754035013866 stacking interactions; other site 754035013867 hinge regions; other site 754035013868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035013869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035013870 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 754035013871 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035013872 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 754035013873 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 754035013874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035013875 DNA-binding site [nucleotide binding]; DNA binding site 754035013876 RNA-binding motif; other site 754035013877 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 754035013878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035013879 NAD(P) binding site [chemical binding]; other site 754035013880 active site 754035013881 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 754035013882 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035013883 putative C-terminal domain interface [polypeptide binding]; other site 754035013884 putative GSH binding site (G-site) [chemical binding]; other site 754035013885 putative dimer interface [polypeptide binding]; other site 754035013886 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 754035013887 putative N-terminal domain interface [polypeptide binding]; other site 754035013888 putative dimer interface [polypeptide binding]; other site 754035013889 putative substrate binding pocket (H-site) [chemical binding]; other site 754035013890 CsbD-like; Region: CsbD; pfam05532 754035013891 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 754035013892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035013893 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 754035013894 short chain dehydrogenase; Provisional; Region: PRK06500 754035013895 classical (c) SDRs; Region: SDR_c; cd05233 754035013896 NAD(P) binding site [chemical binding]; other site 754035013897 active site 754035013898 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 754035013899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035013900 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 754035013901 substrate binding pocket [chemical binding]; other site 754035013902 dimerization interface [polypeptide binding]; other site 754035013903 Cupin domain; Region: Cupin_2; pfam07883 754035013904 fumarate hydratase; Reviewed; Region: fumC; PRK00485 754035013905 Class II fumarases; Region: Fumarase_classII; cd01362 754035013906 active site 754035013907 tetramer interface [polypeptide binding]; other site 754035013908 Predicted membrane protein [Function unknown]; Region: COG2259 754035013909 Predicted membrane protein [Function unknown]; Region: COG2259 754035013910 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 754035013911 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754035013912 polyphosphate kinase; Provisional; Region: PRK05443 754035013913 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 754035013914 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 754035013915 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 754035013916 putative domain interface [polypeptide binding]; other site 754035013917 putative active site [active] 754035013918 catalytic site [active] 754035013919 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 754035013920 putative domain interface [polypeptide binding]; other site 754035013921 putative active site [active] 754035013922 catalytic site [active] 754035013923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 754035013924 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035013925 salicylate hydroxylase; Provisional; Region: PRK08163 754035013926 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 754035013927 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035013928 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035013929 Walker A/P-loop; other site 754035013930 ATP binding site [chemical binding]; other site 754035013931 Q-loop/lid; other site 754035013932 ABC transporter signature motif; other site 754035013933 Walker B; other site 754035013934 D-loop; other site 754035013935 H-loop/switch region; other site 754035013936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013937 dimer interface [polypeptide binding]; other site 754035013938 conserved gate region; other site 754035013939 putative PBP binding loops; other site 754035013940 ABC-ATPase subunit interface; other site 754035013941 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 754035013942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035013943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035013944 dimer interface [polypeptide binding]; other site 754035013945 conserved gate region; other site 754035013946 putative PBP binding loops; other site 754035013947 ABC-ATPase subunit interface; other site 754035013948 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 754035013949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035013950 substrate binding pocket [chemical binding]; other site 754035013951 membrane-bound complex binding site; other site 754035013952 hinge residues; other site 754035013953 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 754035013954 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 754035013955 Uncharacterized conserved protein [Function unknown]; Region: COG5588 754035013956 cystathionine beta-lyase; Provisional; Region: PRK05967 754035013957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754035013958 homodimer interface [polypeptide binding]; other site 754035013959 substrate-cofactor binding pocket; other site 754035013960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035013961 catalytic residue [active] 754035013962 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 754035013963 HPP family; Region: HPP; pfam04982 754035013964 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 754035013965 RNA polymerase sigma factor; Provisional; Region: PRK11922 754035013966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035013967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035013968 DNA binding residues [nucleotide binding] 754035013969 Predicted outer membrane protein [Function unknown]; Region: COG3652 754035013970 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 754035013971 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 754035013972 enoyl-CoA hydratase; Provisional; Region: PRK05980 754035013973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035013974 substrate binding site [chemical binding]; other site 754035013975 oxyanion hole (OAH) forming residues; other site 754035013976 trimer interface [polypeptide binding]; other site 754035013977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035013978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035013979 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 754035013980 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 754035013981 transmembrane helices; other site 754035013982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035013983 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754035013984 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035013985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035013986 metal binding site [ion binding]; metal-binding site 754035013987 active site 754035013988 I-site; other site 754035013989 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 754035013990 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 754035013991 putative active site [active] 754035013992 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 754035013993 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 754035013994 hypothetical protein; Validated; Region: PRK09087 754035013995 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754035013996 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754035013997 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 754035013998 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 754035013999 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 754035014000 dimerization interface [polypeptide binding]; other site 754035014001 putative ATP binding site [chemical binding]; other site 754035014002 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 754035014003 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 754035014004 active site 754035014005 substrate binding site [chemical binding]; other site 754035014006 cosubstrate binding site; other site 754035014007 catalytic site [active] 754035014008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035014009 catalytic core [active] 754035014010 Protein of unknown function (DUF680); Region: DUF680; pfam05079 754035014011 Protein of unknown function (DUF680); Region: DUF680; pfam05079 754035014012 Protein of unknown function (DUF680); Region: DUF680; pfam05079 754035014013 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 754035014014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035014015 active site 754035014016 phosphorylation site [posttranslational modification] 754035014017 intermolecular recognition site; other site 754035014018 dimerization interface [polypeptide binding]; other site 754035014019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035014020 DNA binding site [nucleotide binding] 754035014021 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 754035014022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035014023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035014024 dimer interface [polypeptide binding]; other site 754035014025 phosphorylation site [posttranslational modification] 754035014026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035014027 ATP binding site [chemical binding]; other site 754035014028 Mg2+ binding site [ion binding]; other site 754035014029 G-X-G motif; other site 754035014030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035014031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035014032 ABC-ATPase subunit interface; other site 754035014033 putative PBP binding loops; other site 754035014034 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035014035 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035014036 Walker A/P-loop; other site 754035014037 ATP binding site [chemical binding]; other site 754035014038 Q-loop/lid; other site 754035014039 ABC transporter signature motif; other site 754035014040 Walker B; other site 754035014041 D-loop; other site 754035014042 H-loop/switch region; other site 754035014043 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 754035014044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 754035014045 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 754035014046 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 754035014047 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 754035014048 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 754035014049 Part of AAA domain; Region: AAA_19; pfam13245 754035014050 Family description; Region: UvrD_C_2; pfam13538 754035014051 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754035014052 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 754035014053 metal binding site [ion binding]; metal-binding site 754035014054 putative dimer interface [polypeptide binding]; other site 754035014055 allantoate amidohydrolase; Reviewed; Region: PRK12890 754035014056 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 754035014057 active site 754035014058 metal binding site [ion binding]; metal-binding site 754035014059 dimer interface [polypeptide binding]; other site 754035014060 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 754035014061 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 754035014062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035014063 catalytic residue [active] 754035014064 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035014065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035014066 putative DNA binding site [nucleotide binding]; other site 754035014067 putative Zn2+ binding site [ion binding]; other site 754035014068 AsnC family; Region: AsnC_trans_reg; pfam01037 754035014069 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 754035014070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 754035014071 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 754035014072 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 754035014073 putative [4Fe-4S] binding site [ion binding]; other site 754035014074 putative molybdopterin cofactor binding site [chemical binding]; other site 754035014075 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 754035014076 putative molybdopterin cofactor binding site; other site 754035014077 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754035014078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035014079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035014080 Walker A/P-loop; other site 754035014081 ATP binding site [chemical binding]; other site 754035014082 Q-loop/lid; other site 754035014083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035014084 ABC transporter signature motif; other site 754035014085 Walker B; other site 754035014086 D-loop; other site 754035014087 ABC transporter; Region: ABC_tran_2; pfam12848 754035014088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754035014089 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 754035014090 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035014091 EamA-like transporter family; Region: EamA; pfam00892 754035014092 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035014093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035014094 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035014095 dimerization interface [polypeptide binding]; other site 754035014096 substrate binding pocket [chemical binding]; other site 754035014097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 754035014098 DinB superfamily; Region: DinB_2; pfam12867 754035014099 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 754035014100 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035014101 putative C-terminal domain interface [polypeptide binding]; other site 754035014102 putative GSH binding site (G-site) [chemical binding]; other site 754035014103 putative dimer interface [polypeptide binding]; other site 754035014104 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 754035014105 putative N-terminal domain interface [polypeptide binding]; other site 754035014106 putative dimer interface [polypeptide binding]; other site 754035014107 putative substrate binding pocket (H-site) [chemical binding]; other site 754035014108 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 754035014109 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 754035014110 active site 754035014111 multimer interface [polypeptide binding]; other site 754035014112 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 754035014113 MoaE homodimer interface [polypeptide binding]; other site 754035014114 MoaD interaction [polypeptide binding]; other site 754035014115 active site residues [active] 754035014116 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 754035014117 MoaE interaction surface [polypeptide binding]; other site 754035014118 MoeB interaction surface [polypeptide binding]; other site 754035014119 thiocarboxylated glycine; other site 754035014120 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 754035014121 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 754035014122 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 754035014123 GIY-YIG motif/motif A; other site 754035014124 active site 754035014125 catalytic site [active] 754035014126 putative DNA binding site [nucleotide binding]; other site 754035014127 metal binding site [ion binding]; metal-binding site 754035014128 UvrB/uvrC motif; Region: UVR; pfam02151 754035014129 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 754035014130 short chain dehydrogenase; Provisional; Region: PRK09134 754035014131 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 754035014132 NADP binding site [chemical binding]; other site 754035014133 substrate binding pocket [chemical binding]; other site 754035014134 active site 754035014135 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 754035014136 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035014137 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 754035014138 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 754035014139 dimer interface [polypeptide binding]; other site 754035014140 N-terminal domain interface [polypeptide binding]; other site 754035014141 putative substrate binding pocket (H-site) [chemical binding]; other site 754035014142 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035014143 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 754035014144 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 754035014145 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 754035014146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035014147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035014148 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 754035014149 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754035014150 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 754035014151 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035014152 NAD binding site [chemical binding]; other site 754035014153 putative substrate binding site 2 [chemical binding]; other site 754035014154 putative substrate binding site 1 [chemical binding]; other site 754035014155 active site 754035014156 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754035014157 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 754035014158 NAD binding site [chemical binding]; other site 754035014159 homodimer interface [polypeptide binding]; other site 754035014160 active site 754035014161 substrate binding site [chemical binding]; other site 754035014162 Protein of unknown function (DUF995); Region: DUF995; pfam06191 754035014163 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 754035014164 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 754035014165 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754035014166 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 754035014167 Ligand binding site; other site 754035014168 Putative Catalytic site; other site 754035014169 DXD motif; other site 754035014170 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 754035014171 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 754035014172 DXD motif; other site 754035014173 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 754035014174 Protein of unknown function (DUF995); Region: DUF995; pfam06191 754035014175 DNA polymerase III subunit chi; Validated; Region: PRK05728 754035014176 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754035014177 multifunctional aminopeptidase A; Provisional; Region: PRK00913 754035014178 interface (dimer of trimers) [polypeptide binding]; other site 754035014179 Substrate-binding/catalytic site; other site 754035014180 Zn-binding sites [ion binding]; other site 754035014181 Predicted permeases [General function prediction only]; Region: COG0795 754035014182 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 754035014183 Predicted permeases [General function prediction only]; Region: COG0795 754035014184 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 754035014185 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 754035014186 OstA-like protein; Region: OstA; cl00844 754035014187 Organic solvent tolerance protein; Region: OstA_C; pfam04453 754035014188 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 754035014189 SurA N-terminal domain; Region: SurA_N; pfam09312 754035014190 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 754035014191 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 754035014192 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 754035014193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035014194 S-adenosylmethionine binding site [chemical binding]; other site 754035014195 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 754035014196 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 754035014197 catalytic site [active] 754035014198 G-X2-G-X-G-K; other site 754035014199 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 754035014200 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 754035014201 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 754035014202 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 754035014203 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 754035014204 dimerization interface [polypeptide binding]; other site 754035014205 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 754035014206 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035014207 dimer interface [polypeptide binding]; other site 754035014208 active site 754035014209 acyl carrier protein; Provisional; Region: acpP; PRK00982 754035014210 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 754035014211 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 754035014212 NAD(P) binding site [chemical binding]; other site 754035014213 homotetramer interface [polypeptide binding]; other site 754035014214 homodimer interface [polypeptide binding]; other site 754035014215 active site 754035014216 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 754035014217 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 754035014218 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 754035014219 Sulfatase; Region: Sulfatase; pfam00884 754035014220 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 754035014221 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 754035014222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 754035014223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 754035014224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 754035014225 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 754035014226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035014227 S-adenosylmethionine binding site [chemical binding]; other site 754035014228 Uncharacterized conserved protein [Function unknown]; Region: COG1742 754035014229 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 754035014230 replicative DNA helicase; Provisional; Region: PRK09165 754035014231 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 754035014232 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 754035014233 Walker A motif; other site 754035014234 ATP binding site [chemical binding]; other site 754035014235 Walker B motif; other site 754035014236 DNA binding loops [nucleotide binding] 754035014237 DNA repair protein RadA; Provisional; Region: PRK11823 754035014238 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754035014239 Walker A motif; other site 754035014240 ATP binding site [chemical binding]; other site 754035014241 Walker B motif; other site 754035014242 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754035014243 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 754035014244 Colicin V production protein; Region: Colicin_V; pfam02674 754035014245 amidophosphoribosyltransferase; Provisional; Region: PRK09123 754035014246 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 754035014247 active site 754035014248 tetramer interface [polypeptide binding]; other site 754035014249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035014250 active site 754035014251 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 754035014252 classical (c) SDRs; Region: SDR_c; cd05233 754035014253 NAD(P) binding site [chemical binding]; other site 754035014254 active site 754035014255 OsmC-like protein; Region: OsmC; pfam02566 754035014256 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 754035014257 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 754035014258 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 754035014259 agmatine deiminase; Region: agmatine_aguA; TIGR03380 754035014260 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 754035014261 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035014262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035014263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035014264 DNA binding residues [nucleotide binding] 754035014265 dimerization interface [polypeptide binding]; other site 754035014266 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 754035014267 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754035014268 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 754035014269 N-terminal domain interface [polypeptide binding]; other site 754035014270 dimer interface [polypeptide binding]; other site 754035014271 substrate binding pocket (H-site) [chemical binding]; other site 754035014272 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 754035014273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035014274 Zn binding site [ion binding]; other site 754035014275 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035014276 EamA-like transporter family; Region: EamA; pfam00892 754035014277 EamA-like transporter family; Region: EamA; pfam00892 754035014278 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754035014279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035014280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035014281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035014282 dimerization interface [polypeptide binding]; other site 754035014283 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 754035014284 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754035014285 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 754035014286 putative acyl-acceptor binding pocket; other site 754035014287 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 754035014288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754035014289 acyl-activating enzyme (AAE) consensus motif; other site 754035014290 AMP binding site [chemical binding]; other site 754035014291 active site 754035014292 CoA binding site [chemical binding]; other site 754035014293 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 754035014294 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 754035014295 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 754035014296 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 754035014297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035014298 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 754035014299 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 754035014300 Walker A/P-loop; other site 754035014301 ATP binding site [chemical binding]; other site 754035014302 Q-loop/lid; other site 754035014303 ABC transporter signature motif; other site 754035014304 Walker B; other site 754035014305 D-loop; other site 754035014306 H-loop/switch region; other site 754035014307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035014308 dimerization interface [polypeptide binding]; other site 754035014309 putative DNA binding site [nucleotide binding]; other site 754035014310 putative Zn2+ binding site [ion binding]; other site 754035014311 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 754035014312 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 754035014313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754035014314 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 754035014315 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 754035014316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035014317 NAD(P) binding site [chemical binding]; other site 754035014318 active site 754035014319 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 754035014320 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 754035014321 Cl binding site [ion binding]; other site 754035014322 oligomer interface [polypeptide binding]; other site 754035014323 Predicted permeases [General function prediction only]; Region: RarD; COG2962 754035014324 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 754035014325 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 754035014326 active site 754035014327 catalytic residues [active] 754035014328 metal binding site [ion binding]; metal-binding site 754035014329 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 754035014330 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 754035014331 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035014332 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035014333 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 754035014334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035014335 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 754035014336 putative active site [active] 754035014337 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 754035014338 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754035014339 active site 754035014340 HIGH motif; other site 754035014341 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754035014342 KMSKS motif; other site 754035014343 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 754035014344 Uncharacterized conserved protein [Function unknown]; Region: COG2135 754035014345 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 754035014346 nudix motif; other site 754035014347 TIGR02301 family protein; Region: TIGR02301 754035014348 dihydroorotase; Validated; Region: PRK09060 754035014349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754035014350 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 754035014351 active site 754035014352 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 754035014353 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 754035014354 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035014355 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 754035014356 PAS fold; Region: PAS_7; pfam12860 754035014357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 754035014358 PAS fold; Region: PAS_7; pfam12860 754035014359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035014360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035014361 metal binding site [ion binding]; metal-binding site 754035014362 active site 754035014363 I-site; other site 754035014364 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035014365 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 754035014366 Fatty acid desaturase; Region: FA_desaturase; pfam00487 754035014367 putative di-iron ligands [ion binding]; other site 754035014368 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035014369 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035014370 dimerization interface [polypeptide binding]; other site 754035014371 substrate binding pocket [chemical binding]; other site 754035014372 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 754035014373 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 754035014374 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035014375 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 754035014376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035014377 Coenzyme A binding pocket [chemical binding]; other site 754035014378 Peptidase_C39 like family; Region: DUF3335; pfam11814 754035014379 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 754035014380 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 754035014381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035014382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035014383 DNA binding residues [nucleotide binding] 754035014384 Predicted membrane protein [Function unknown]; Region: COG5373 754035014385 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754035014386 CoenzymeA binding site [chemical binding]; other site 754035014387 subunit interaction site [polypeptide binding]; other site 754035014388 PHB binding site; other site 754035014389 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 754035014390 Recombination protein O N terminal; Region: RecO_N; pfam11967 754035014391 Recombination protein O C terminal; Region: RecO_C; pfam02565 754035014392 Porin subfamily; Region: Porin_2; pfam02530 754035014393 GTPase Era; Reviewed; Region: era; PRK00089 754035014394 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 754035014395 G1 box; other site 754035014396 GTP/Mg2+ binding site [chemical binding]; other site 754035014397 Switch I region; other site 754035014398 G2 box; other site 754035014399 Switch II region; other site 754035014400 G3 box; other site 754035014401 G4 box; other site 754035014402 G5 box; other site 754035014403 KH domain; Region: KH_2; pfam07650 754035014404 ribonuclease III; Reviewed; Region: PRK12371 754035014405 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 754035014406 dimerization interface [polypeptide binding]; other site 754035014407 active site 754035014408 metal binding site [ion binding]; metal-binding site 754035014409 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 754035014410 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 754035014411 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754035014412 Catalytic site [active] 754035014413 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754035014414 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 754035014415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 754035014416 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 754035014417 dimer interface [polypeptide binding]; other site 754035014418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035014419 metal binding site [ion binding]; metal-binding site 754035014420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754035014421 active site 754035014422 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 754035014423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754035014424 Zn2+ binding site [ion binding]; other site 754035014425 Mg2+ binding site [ion binding]; other site 754035014426 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754035014427 synthetase active site [active] 754035014428 NTP binding site [chemical binding]; other site 754035014429 metal binding site [ion binding]; metal-binding site 754035014430 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754035014431 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754035014432 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 754035014433 Uncharacterized conserved protein [Function unknown]; Region: COG1432 754035014434 LabA_like proteins; Region: LabA; cd10911 754035014435 putative metal binding site [ion binding]; other site 754035014436 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 754035014437 Fe-S cluster binding site [ion binding]; other site 754035014438 DNA binding site [nucleotide binding] 754035014439 active site 754035014440 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035014441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035014442 putative DNA binding site [nucleotide binding]; other site 754035014443 putative Zn2+ binding site [ion binding]; other site 754035014444 AsnC family; Region: AsnC_trans_reg; pfam01037 754035014445 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 754035014446 SmpB-tmRNA interface; other site 754035014447 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 754035014448 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 754035014449 dimer interface [polypeptide binding]; other site 754035014450 active site 754035014451 catalytic residue [active] 754035014452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035014453 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 754035014454 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 754035014455 dimer interface [polypeptide binding]; other site 754035014456 active site 754035014457 catalytic residues [active] 754035014458 Int/Topo IB signature motif; other site 754035014459 Porin subfamily; Region: Porin_2; pfam02530 754035014460 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 754035014461 GIY-YIG motif/motif A; other site 754035014462 active site 754035014463 catalytic site [active] 754035014464 metal binding site [ion binding]; metal-binding site 754035014465 Porin subfamily; Region: Porin_2; pfam02530 754035014466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035014467 binding surface 754035014468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 754035014469 TPR motif; other site 754035014470 TPR repeat; Region: TPR_11; pfam13414 754035014471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035014472 binding surface 754035014473 TPR motif; other site 754035014474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 754035014475 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 754035014476 TPR repeat; Region: TPR_11; pfam13414 754035014477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035014478 TPR motif; other site 754035014479 TPR repeat; Region: TPR_11; pfam13414 754035014480 binding surface 754035014481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035014482 binding surface 754035014483 Tetratricopeptide repeat; Region: TPR_16; pfam13432 754035014484 TPR motif; other site 754035014485 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 754035014486 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 754035014487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035014488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035014489 homodimer interface [polypeptide binding]; other site 754035014490 catalytic residue [active] 754035014491 Acylphosphatase; Region: Acylphosphatase; cl00551 754035014492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035014493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035014494 isovaleryl-CoA dehydrogenase; Region: PLN02519 754035014495 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 754035014496 substrate binding site [chemical binding]; other site 754035014497 FAD binding site [chemical binding]; other site 754035014498 catalytic base [active] 754035014499 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 754035014500 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 754035014501 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 754035014502 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 754035014503 putative ADP-ribose binding site [chemical binding]; other site 754035014504 putative active site [active] 754035014505 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 754035014506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754035014507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035014508 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754035014509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754035014510 carboxyltransferase (CT) interaction site; other site 754035014511 biotinylation site [posttranslational modification]; other site 754035014512 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035014513 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 754035014514 dimerization interface [polypeptide binding]; other site 754035014515 ligand binding site [chemical binding]; other site 754035014516 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754035014517 Sel1 repeat; Region: Sel1; cl02723 754035014518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 754035014519 AMP nucleosidase; Provisional; Region: PRK08292 754035014520 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 754035014521 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 754035014522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 754035014523 putative catalytic site [active] 754035014524 putative metal binding site [ion binding]; other site 754035014525 putative phosphate binding site [ion binding]; other site 754035014526 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 754035014527 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 754035014528 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035014529 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 754035014530 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 754035014531 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 754035014532 Fe-S cluster binding site [ion binding]; other site 754035014533 active site 754035014534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035014535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035014536 non-specific DNA binding site [nucleotide binding]; other site 754035014537 salt bridge; other site 754035014538 sequence-specific DNA binding site [nucleotide binding]; other site 754035014539 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754035014540 aminopeptidase N; Provisional; Region: pepN; PRK14015 754035014541 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 754035014542 active site 754035014543 Zn binding site [ion binding]; other site 754035014544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035014545 PAS fold; Region: PAS_3; pfam08447 754035014546 putative active site [active] 754035014547 heme pocket [chemical binding]; other site 754035014548 PAS fold; Region: PAS_7; pfam12860 754035014549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035014550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035014551 dimer interface [polypeptide binding]; other site 754035014552 phosphorylation site [posttranslational modification] 754035014553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035014554 ATP binding site [chemical binding]; other site 754035014555 Mg2+ binding site [ion binding]; other site 754035014556 G-X-G motif; other site 754035014557 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 754035014558 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754035014559 metal binding triad; other site 754035014560 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754035014561 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754035014562 metal binding triad; other site 754035014563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754035014564 dimerization interface [polypeptide binding]; other site 754035014565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035014566 dimer interface [polypeptide binding]; other site 754035014567 phosphorylation site [posttranslational modification] 754035014568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035014569 ATP binding site [chemical binding]; other site 754035014570 Mg2+ binding site [ion binding]; other site 754035014571 G-X-G motif; other site 754035014572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035014573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035014574 active site 754035014575 phosphorylation site [posttranslational modification] 754035014576 intermolecular recognition site; other site 754035014577 dimerization interface [polypeptide binding]; other site 754035014578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035014579 DNA binding site [nucleotide binding] 754035014580 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 754035014581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754035014582 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035014583 protein binding site [polypeptide binding]; other site 754035014584 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754035014585 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 754035014586 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 754035014587 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 754035014588 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 754035014589 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 754035014590 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 754035014591 sensor protein PhoQ; Provisional; Region: PRK10815 754035014592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035014593 ATP binding site [chemical binding]; other site 754035014594 G-X-G motif; other site 754035014595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035014596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035014597 active site 754035014598 phosphorylation site [posttranslational modification] 754035014599 intermolecular recognition site; other site 754035014600 dimerization interface [polypeptide binding]; other site 754035014601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035014602 DNA binding site [nucleotide binding] 754035014603 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 754035014604 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 754035014605 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035014606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035014607 dimer interface [polypeptide binding]; other site 754035014608 conserved gate region; other site 754035014609 putative PBP binding loops; other site 754035014610 ABC-ATPase subunit interface; other site 754035014611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035014612 putative PBP binding loops; other site 754035014613 dimer interface [polypeptide binding]; other site 754035014614 ABC-ATPase subunit interface; other site 754035014615 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754035014616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035014617 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035014618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035014619 Walker A/P-loop; other site 754035014620 ATP binding site [chemical binding]; other site 754035014621 Q-loop/lid; other site 754035014622 ABC transporter signature motif; other site 754035014623 Walker B; other site 754035014624 D-loop; other site 754035014625 H-loop/switch region; other site 754035014626 TOBE domain; Region: TOBE_2; pfam08402 754035014627 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035014628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035014629 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035014630 dimerization interface [polypeptide binding]; other site 754035014631 substrate binding pocket [chemical binding]; other site 754035014632 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754035014633 amidohydrolase; Region: amidohydrolases; TIGR01891 754035014634 metal binding site [ion binding]; metal-binding site 754035014635 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 754035014636 Amidinotransferase; Region: Amidinotransf; pfam02274 754035014637 Transglycosylase; Region: Transgly; pfam00912 754035014638 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 754035014639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754035014640 Uncharacterized conserved protein [Function unknown]; Region: COG5402 754035014641 Predicted integral membrane protein [Function unknown]; Region: COG5436 754035014642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 754035014643 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 754035014644 Uncharacterized conserved protein [Function unknown]; Region: COG5447 754035014645 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 754035014646 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035014647 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2; Region: tRNA_synt_1c_R2; pfam04557 754035014648 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035014649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035014650 putative active site [active] 754035014651 heme pocket [chemical binding]; other site 754035014652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035014653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035014654 dimer interface [polypeptide binding]; other site 754035014655 phosphorylation site [posttranslational modification] 754035014656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035014657 ATP binding site [chemical binding]; other site 754035014658 Mg2+ binding site [ion binding]; other site 754035014659 G-X-G motif; other site 754035014660 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 754035014661 Predicted transcriptional regulator [Transcription]; Region: COG4957 754035014662 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 754035014663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035014664 Proteins containing SET domain [General function prediction only]; Region: COG2940 754035014665 SET domain; Region: SET; pfam00856 754035014666 Cytochrome c; Region: Cytochrom_C; pfam00034 754035014667 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 754035014668 Cytochrome c556 [Energy production and conversion]; Region: COG3909 754035014669 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 754035014670 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 754035014671 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 754035014672 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754035014673 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 754035014674 homodimer interface [polypeptide binding]; other site 754035014675 substrate-cofactor binding pocket; other site 754035014676 catalytic residue [active] 754035014677 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 754035014678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035014679 motif II; other site 754035014680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035014681 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035014682 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 754035014683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 754035014684 motif II; other site 754035014685 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 754035014686 heterodimer interface [polypeptide binding]; other site 754035014687 substrate interaction site [chemical binding]; other site 754035014688 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 754035014689 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 754035014690 active site 754035014691 substrate binding site [chemical binding]; other site 754035014692 coenzyme B12 binding site [chemical binding]; other site 754035014693 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 754035014694 B12 binding site [chemical binding]; other site 754035014695 cobalt ligand [ion binding]; other site 754035014696 putative addiction module antidote; Region: doc_partner; TIGR02609 754035014697 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 754035014698 transcription elongation factor regulatory protein; Validated; Region: PRK06342 754035014699 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754035014700 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 754035014701 L-asparaginase II; Region: Asparaginase_II; cl01842 754035014702 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 754035014703 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 754035014704 active site 754035014705 transcriptional regulator BetI; Validated; Region: PRK00767 754035014706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035014707 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 754035014708 choline-sulfatase; Region: chol_sulfatase; TIGR03417 754035014709 Sulfatase; Region: Sulfatase; cl17466 754035014710 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 754035014711 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 754035014712 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754035014713 tetramer interface [polypeptide binding]; other site 754035014714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035014715 catalytic residue [active] 754035014716 choline dehydrogenase; Validated; Region: PRK02106 754035014717 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 754035014718 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 754035014719 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 754035014720 NAD(P) binding site [chemical binding]; other site 754035014721 catalytic residues [active] 754035014722 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 754035014723 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 754035014724 Substrate binding site; other site 754035014725 Cupin domain; Region: Cupin_2; cl17218 754035014726 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 754035014727 dimerization interface [polypeptide binding]; other site 754035014728 putative active cleft [active] 754035014729 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 754035014730 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 754035014731 active site 754035014732 substrate binding site [chemical binding]; other site 754035014733 metal binding site [ion binding]; metal-binding site 754035014734 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 754035014735 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035014736 Walker A/P-loop; other site 754035014737 ATP binding site [chemical binding]; other site 754035014738 Q-loop/lid; other site 754035014739 ABC transporter signature motif; other site 754035014740 Walker B; other site 754035014741 D-loop; other site 754035014742 H-loop/switch region; other site 754035014743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035014744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035014745 Walker A/P-loop; other site 754035014746 ATP binding site [chemical binding]; other site 754035014747 Q-loop/lid; other site 754035014748 ABC transporter signature motif; other site 754035014749 Walker B; other site 754035014750 D-loop; other site 754035014751 H-loop/switch region; other site 754035014752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035014753 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754035014754 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754035014755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035014756 dimer interface [polypeptide binding]; other site 754035014757 conserved gate region; other site 754035014758 putative PBP binding loops; other site 754035014759 ABC-ATPase subunit interface; other site 754035014760 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 754035014761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035014762 dimer interface [polypeptide binding]; other site 754035014763 conserved gate region; other site 754035014764 putative PBP binding loops; other site 754035014765 ABC-ATPase subunit interface; other site 754035014766 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 754035014767 peptide binding site [polypeptide binding]; other site 754035014768 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 754035014769 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035014770 Predicted membrane protein [Function unknown]; Region: COG4655 754035014771 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 754035014772 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 754035014773 active site 754035014774 catalytic site [active] 754035014775 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 754035014776 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 754035014777 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 754035014778 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 754035014779 active site 754035014780 catalytic site [active] 754035014781 phosphoglucomutase; Region: PLN02307 754035014782 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 754035014783 substrate binding site [chemical binding]; other site 754035014784 dimer interface [polypeptide binding]; other site 754035014785 active site 754035014786 metal binding site [ion binding]; metal-binding site 754035014787 glycogen synthase; Provisional; Region: glgA; PRK00654 754035014788 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 754035014789 ADP-binding pocket [chemical binding]; other site 754035014790 homodimer interface [polypeptide binding]; other site 754035014791 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 754035014792 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 754035014793 ligand binding site; other site 754035014794 oligomer interface; other site 754035014795 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 754035014796 dimer interface [polypeptide binding]; other site 754035014797 N-terminal domain interface [polypeptide binding]; other site 754035014798 sulfate 1 binding site; other site 754035014799 glycogen branching enzyme; Provisional; Region: PRK05402 754035014800 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 754035014801 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 754035014802 active site 754035014803 catalytic site [active] 754035014804 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 754035014805 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 754035014806 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 754035014807 homodimer interface [polypeptide binding]; other site 754035014808 active site pocket [active] 754035014809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035014810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035014811 Walker A/P-loop; other site 754035014812 ATP binding site [chemical binding]; other site 754035014813 Q-loop/lid; other site 754035014814 ABC transporter signature motif; other site 754035014815 Walker B; other site 754035014816 D-loop; other site 754035014817 H-loop/switch region; other site 754035014818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035014819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035014820 TM-ABC transporter signature motif; other site 754035014821 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 754035014822 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035014823 ligand binding site [chemical binding]; other site 754035014824 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035014825 DNA binding site [nucleotide binding] 754035014826 sequence specific DNA binding site [nucleotide binding]; other site 754035014827 putative cAMP binding site [chemical binding]; other site 754035014828 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035014829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035014830 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 754035014831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035014832 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 754035014833 putative substrate binding site [chemical binding]; other site 754035014834 putative ATP binding site [chemical binding]; other site 754035014835 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 754035014836 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 754035014837 inhibitor-cofactor binding pocket; inhibition site 754035014838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035014839 catalytic residue [active] 754035014840 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754035014841 O-Antigen ligase; Region: Wzy_C; pfam04932 754035014842 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754035014843 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 754035014844 active site 754035014845 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 754035014846 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 754035014847 CysD dimerization site [polypeptide binding]; other site 754035014848 G1 box; other site 754035014849 putative GEF interaction site [polypeptide binding]; other site 754035014850 GTP/Mg2+ binding site [chemical binding]; other site 754035014851 Switch I region; other site 754035014852 G2 box; other site 754035014853 G3 box; other site 754035014854 Switch II region; other site 754035014855 G4 box; other site 754035014856 G5 box; other site 754035014857 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 754035014858 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 754035014859 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 754035014860 ligand-binding site [chemical binding]; other site 754035014861 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 754035014862 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754035014863 Active Sites [active] 754035014864 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754035014865 O-Antigen ligase; Region: Wzy_C; pfam04932 754035014866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035014867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035014868 NAD(P) binding site [chemical binding]; other site 754035014869 active site 754035014870 Bacterial sugar transferase; Region: Bac_transf; pfam02397 754035014871 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 754035014872 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 754035014873 NAD(P) binding site [chemical binding]; other site 754035014874 homodimer interface [polypeptide binding]; other site 754035014875 substrate binding site [chemical binding]; other site 754035014876 active site 754035014877 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 754035014878 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 754035014879 active site 754035014880 substrate binding site [chemical binding]; other site 754035014881 metal binding site [ion binding]; metal-binding site 754035014882 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 754035014883 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 754035014884 Substrate binding site; other site 754035014885 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 754035014886 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 754035014887 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 754035014888 NADP-binding site; other site 754035014889 homotetramer interface [polypeptide binding]; other site 754035014890 substrate binding site [chemical binding]; other site 754035014891 homodimer interface [polypeptide binding]; other site 754035014892 active site 754035014893 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 754035014894 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 754035014895 NADP-binding site; other site 754035014896 homotetramer interface [polypeptide binding]; other site 754035014897 substrate binding site [chemical binding]; other site 754035014898 homodimer interface [polypeptide binding]; other site 754035014899 active site 754035014900 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 754035014901 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754035014902 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 754035014903 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 754035014904 Walker A/P-loop; other site 754035014905 ATP binding site [chemical binding]; other site 754035014906 Q-loop/lid; other site 754035014907 ABC transporter signature motif; other site 754035014908 Walker B; other site 754035014909 D-loop; other site 754035014910 H-loop/switch region; other site 754035014911 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 754035014912 putative carbohydrate binding site [chemical binding]; other site 754035014913 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035014914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035014915 S-adenosylmethionine binding site [chemical binding]; other site 754035014916 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 754035014917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035014919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014920 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 754035014921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014922 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 754035014923 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035014924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035014925 S-adenosylmethionine binding site [chemical binding]; other site 754035014926 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 754035014927 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754035014928 Ligand binding site; other site 754035014929 Putative Catalytic site; other site 754035014930 DXD motif; other site 754035014931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014932 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 754035014933 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014934 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 754035014935 putative ADP-binding pocket [chemical binding]; other site 754035014936 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 754035014937 NADP binding site [chemical binding]; other site 754035014938 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 754035014939 active site 754035014940 putative substrate binding site [chemical binding]; other site 754035014941 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 754035014942 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 754035014943 NAD binding site [chemical binding]; other site 754035014944 substrate binding site [chemical binding]; other site 754035014945 homodimer interface [polypeptide binding]; other site 754035014946 active site 754035014947 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 754035014948 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 754035014949 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 754035014950 substrate binding site; other site 754035014951 tetramer interface; other site 754035014952 O-Antigen ligase; Region: Wzy_C; pfam04932 754035014953 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 754035014954 Chain length determinant protein; Region: Wzz; cl15801 754035014955 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 754035014956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754035014957 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 754035014958 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 754035014959 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 754035014960 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 754035014961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014962 putative ADP-binding pocket [chemical binding]; other site 754035014963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035014965 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 754035014966 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754035014967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035014968 S-adenosylmethionine binding site [chemical binding]; other site 754035014969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035014970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014971 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 754035014972 putative ADP-binding pocket [chemical binding]; other site 754035014973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035014974 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 754035014975 putative ADP-binding pocket [chemical binding]; other site 754035014976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035014977 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035014978 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 754035014979 putative NAD(P) binding site [chemical binding]; other site 754035014980 active site 754035014981 putative substrate binding site [chemical binding]; other site 754035014982 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 754035014983 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035014984 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754035014985 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754035014986 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 754035014987 Bacterial sugar transferase; Region: Bac_transf; pfam02397 754035014988 putative acyl-CoA synthetase; Provisional; Region: PRK06018 754035014989 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 754035014990 dimer interface [polypeptide binding]; other site 754035014991 acyl-activating enzyme (AAE) consensus motif; other site 754035014992 putative active site [active] 754035014993 AMP binding site [chemical binding]; other site 754035014994 putative CoA binding site [chemical binding]; other site 754035014995 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 754035014996 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754035014997 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 754035014998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 754035014999 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 754035015000 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 754035015001 NodB motif; other site 754035015002 putative active site [active] 754035015003 putative catalytic site [active] 754035015004 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754035015005 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754035015006 putative active site [active] 754035015007 pyruvate phosphate dikinase; Provisional; Region: PRK09279 754035015008 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 754035015009 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754035015010 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754035015011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754035015012 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 754035015013 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 754035015014 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 754035015015 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 754035015016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035015017 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 754035015018 Walker A/P-loop; other site 754035015019 ATP binding site [chemical binding]; other site 754035015020 Q-loop/lid; other site 754035015021 ABC transporter signature motif; other site 754035015022 Walker B; other site 754035015023 D-loop; other site 754035015024 H-loop/switch region; other site 754035015025 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754035015026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035015027 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035015028 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 754035015029 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 754035015030 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 754035015031 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 754035015032 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 754035015033 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 754035015034 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 754035015035 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 754035015036 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035015037 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754035015038 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 754035015039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035015040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035015041 metal binding site [ion binding]; metal-binding site 754035015042 active site 754035015043 I-site; other site 754035015044 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 754035015045 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 754035015046 Walker A/P-loop; other site 754035015047 ATP binding site [chemical binding]; other site 754035015048 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 754035015049 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 754035015050 ABC transporter signature motif; other site 754035015051 Walker B; other site 754035015052 D-loop; other site 754035015053 H-loop/switch region; other site 754035015054 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754035015055 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 754035015056 catalytic residues [active] 754035015057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 754035015058 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 754035015059 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754035015060 minor groove reading motif; other site 754035015061 helix-hairpin-helix signature motif; other site 754035015062 substrate binding pocket [chemical binding]; other site 754035015063 active site 754035015064 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 754035015065 DNA binding and oxoG recognition site [nucleotide binding] 754035015066 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754035015067 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 754035015068 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 754035015069 DNA methylase; Region: N6_N4_Mtase; pfam01555 754035015070 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 754035015071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035015072 motif II; other site 754035015073 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 754035015074 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 754035015075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035015076 catalytic residue [active] 754035015077 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754035015078 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754035015079 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754035015080 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 754035015081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754035015082 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 754035015083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754035015084 PAS fold; Region: PAS_3; pfam08447 754035015085 putative active site [active] 754035015086 heme pocket [chemical binding]; other site 754035015087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754035015088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754035015089 metal binding site [ion binding]; metal-binding site 754035015090 active site 754035015091 I-site; other site 754035015092 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754035015093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035015094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015095 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754035015096 putative effector binding pocket; other site 754035015097 putative dimerization interface [polypeptide binding]; other site 754035015098 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754035015099 hypothetical protein; Validated; Region: PRK00228 754035015100 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 754035015101 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 754035015102 catalytic triad [active] 754035015103 dimer interface [polypeptide binding]; other site 754035015104 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 754035015105 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 754035015106 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 754035015107 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 754035015108 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 754035015109 RNA/DNA hybrid binding site [nucleotide binding]; other site 754035015110 active site 754035015111 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 754035015112 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 754035015113 putative active site [active] 754035015114 putative substrate binding site [chemical binding]; other site 754035015115 ATP binding site [chemical binding]; other site 754035015116 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 754035015117 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 754035015118 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 754035015119 Protein of unknown function (DUF983); Region: DUF983; cl02211 754035015120 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 754035015121 Subunit III/VIIa interface [polypeptide binding]; other site 754035015122 Phospholipid binding site [chemical binding]; other site 754035015123 Subunit I/III interface [polypeptide binding]; other site 754035015124 Subunit III/VIb interface [polypeptide binding]; other site 754035015125 Subunit III/VIa interface; other site 754035015126 Subunit III/Vb interface [polypeptide binding]; other site 754035015127 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 754035015128 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 754035015129 UbiA prenyltransferase family; Region: UbiA; pfam01040 754035015130 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 754035015131 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 754035015132 Subunit I/III interface [polypeptide binding]; other site 754035015133 D-pathway; other site 754035015134 Subunit I/VIIc interface [polypeptide binding]; other site 754035015135 Subunit I/IV interface [polypeptide binding]; other site 754035015136 Subunit I/II interface [polypeptide binding]; other site 754035015137 Low-spin heme (heme a) binding site [chemical binding]; other site 754035015138 Subunit I/VIIa interface [polypeptide binding]; other site 754035015139 Subunit I/VIa interface [polypeptide binding]; other site 754035015140 Dimer interface; other site 754035015141 Putative water exit pathway; other site 754035015142 Binuclear center (heme a3/CuB) [ion binding]; other site 754035015143 K-pathway; other site 754035015144 Subunit I/Vb interface [polypeptide binding]; other site 754035015145 Putative proton exit pathway; other site 754035015146 Subunit I/VIb interface; other site 754035015147 Subunit I/VIc interface [polypeptide binding]; other site 754035015148 Electron transfer pathway; other site 754035015149 Subunit I/VIIIb interface [polypeptide binding]; other site 754035015150 Subunit I/VIIb interface [polypeptide binding]; other site 754035015151 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 754035015152 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 754035015153 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 754035015154 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 754035015155 protease TldD; Provisional; Region: tldD; PRK10735 754035015156 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 754035015157 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 754035015158 TRAM domain; Region: TRAM; cl01282 754035015159 Methyltransferase domain; Region: Methyltransf_26; pfam13659 754035015160 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 754035015161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754035015162 RNA binding surface [nucleotide binding]; other site 754035015163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035015164 S-adenosylmethionine binding site [chemical binding]; other site 754035015165 Uncharacterized conserved protein [Function unknown]; Region: COG3791 754035015166 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 754035015167 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 754035015168 TPP-binding site; other site 754035015169 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754035015170 PYR/PP interface [polypeptide binding]; other site 754035015171 dimer interface [polypeptide binding]; other site 754035015172 TPP binding site [chemical binding]; other site 754035015173 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754035015174 Pirin-related protein [General function prediction only]; Region: COG1741 754035015175 Pirin; Region: Pirin; pfam02678 754035015176 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 754035015177 Uncharacterized conserved protein [Function unknown]; Region: COG5552 754035015178 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 754035015179 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 754035015180 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 754035015181 putative active site [active] 754035015182 Zn binding site [ion binding]; other site 754035015183 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 754035015184 putative FMN binding site [chemical binding]; other site 754035015185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035015186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035015187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754035015188 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 754035015189 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 754035015190 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 754035015191 dimerization interface [polypeptide binding]; other site 754035015192 active site 754035015193 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 754035015194 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 754035015195 Tetramer interface [polypeptide binding]; other site 754035015196 active site 754035015197 FMN-binding site [chemical binding]; other site 754035015198 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 754035015199 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035015200 catalytic core [active] 754035015201 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 754035015202 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 754035015203 NAD binding site [chemical binding]; other site 754035015204 homotetramer interface [polypeptide binding]; other site 754035015205 homodimer interface [polypeptide binding]; other site 754035015206 substrate binding site [chemical binding]; other site 754035015207 active site 754035015208 chaperone protein DnaJ; Provisional; Region: PRK14299 754035015209 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754035015210 HSP70 interaction site [polypeptide binding]; other site 754035015211 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754035015212 substrate binding site [polypeptide binding]; other site 754035015213 dimer interface [polypeptide binding]; other site 754035015214 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 754035015215 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 754035015216 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 754035015217 enoyl-CoA hydratase; Provisional; Region: PRK06688 754035015218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035015219 substrate binding site [chemical binding]; other site 754035015220 oxyanion hole (OAH) forming residues; other site 754035015221 trimer interface [polypeptide binding]; other site 754035015222 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035015223 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 754035015224 active site 754035015225 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 754035015226 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 754035015227 active site 754035015228 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 754035015229 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 754035015230 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 754035015231 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 754035015232 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 754035015233 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 754035015234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035015235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015236 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 754035015237 putative substrate binding pocket [chemical binding]; other site 754035015238 dimerization interface [polypeptide binding]; other site 754035015239 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 754035015240 UbiA prenyltransferase family; Region: UbiA; pfam01040 754035015241 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035015242 FAD binding domain; Region: FAD_binding_4; pfam01565 754035015243 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 754035015244 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 754035015245 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 754035015246 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 754035015247 dimer interface [polypeptide binding]; other site 754035015248 motif 1; other site 754035015249 active site 754035015250 motif 2; other site 754035015251 motif 3; other site 754035015252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754035015253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035015254 Coenzyme A binding pocket [chemical binding]; other site 754035015255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035015256 TPR motif; other site 754035015257 binding surface 754035015258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035015259 binding surface 754035015260 TPR motif; other site 754035015261 TPR repeat; Region: TPR_11; pfam13414 754035015262 TPR repeat; Region: TPR_11; pfam13414 754035015263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035015264 binding surface 754035015265 TPR motif; other site 754035015266 Uncharacterized conserved protein [Function unknown]; Region: COG3543 754035015267 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 754035015268 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035015269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015270 DNA-binding site [nucleotide binding]; DNA binding site 754035015271 FCD domain; Region: FCD; pfam07729 754035015272 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754035015273 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754035015274 substrate binding pocket [chemical binding]; other site 754035015275 chain length determination region; other site 754035015276 substrate-Mg2+ binding site; other site 754035015277 catalytic residues [active] 754035015278 aspartate-rich region 1; other site 754035015279 active site lid residues [active] 754035015280 aspartate-rich region 2; other site 754035015281 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 754035015282 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 754035015283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754035015284 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 754035015285 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754035015286 tandem repeat interface [polypeptide binding]; other site 754035015287 oligomer interface [polypeptide binding]; other site 754035015288 active site residues [active] 754035015289 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 754035015290 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 754035015291 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754035015292 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 754035015293 MPT binding site; other site 754035015294 trimer interface [polypeptide binding]; other site 754035015295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754035015296 active site 754035015297 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 754035015298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035015299 FeS/SAM binding site; other site 754035015300 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 754035015301 RNA/DNA hybrid binding site [nucleotide binding]; other site 754035015302 active site 754035015303 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 754035015304 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 754035015305 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 754035015306 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 754035015307 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 754035015308 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 754035015309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 754035015310 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 754035015311 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 754035015312 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035015313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035015314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035015316 dimerization interface [polypeptide binding]; other site 754035015317 GTP-binding protein Der; Reviewed; Region: PRK00093 754035015318 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 754035015319 G1 box; other site 754035015320 GTP/Mg2+ binding site [chemical binding]; other site 754035015321 Switch I region; other site 754035015322 G2 box; other site 754035015323 Switch II region; other site 754035015324 G3 box; other site 754035015325 G4 box; other site 754035015326 G5 box; other site 754035015327 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 754035015328 G1 box; other site 754035015329 GTP/Mg2+ binding site [chemical binding]; other site 754035015330 Switch I region; other site 754035015331 G2 box; other site 754035015332 G3 box; other site 754035015333 Switch II region; other site 754035015334 G4 box; other site 754035015335 G5 box; other site 754035015336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 754035015337 microcin B17 transporter; Reviewed; Region: PRK11098 754035015338 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 754035015339 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035015340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015341 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754035015342 dimerization interface [polypeptide binding]; other site 754035015343 substrate binding pocket [chemical binding]; other site 754035015344 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 754035015345 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 754035015346 Uncharacterized conserved protein [Function unknown]; Region: COG3189 754035015347 ArsC family; Region: ArsC; pfam03960 754035015348 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 754035015349 putative catalytic residues [active] 754035015350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035015351 dimerization interface [polypeptide binding]; other site 754035015352 putative DNA binding site [nucleotide binding]; other site 754035015353 putative Zn2+ binding site [ion binding]; other site 754035015354 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 754035015355 putative hydrophobic ligand binding site [chemical binding]; other site 754035015356 SnoaL-like domain; Region: SnoaL_2; pfam12680 754035015357 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 754035015358 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 754035015359 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035015360 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035015361 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 754035015362 putative ligand binding site [chemical binding]; other site 754035015363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035015365 TM-ABC transporter signature motif; other site 754035015366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035015367 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035015368 Walker A/P-loop; other site 754035015369 ATP binding site [chemical binding]; other site 754035015370 Q-loop/lid; other site 754035015371 ABC transporter signature motif; other site 754035015372 Walker B; other site 754035015373 D-loop; other site 754035015374 H-loop/switch region; other site 754035015375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035015376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035015377 DNA binding site [nucleotide binding] 754035015378 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 754035015379 putative ligand binding site [chemical binding]; other site 754035015380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035015381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035015382 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035015383 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035015384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035015385 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035015386 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754035015387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035015389 dimerization interface [polypeptide binding]; other site 754035015390 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 754035015391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035015392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015393 DNA-binding site [nucleotide binding]; DNA binding site 754035015394 FCD domain; Region: FCD; pfam07729 754035015395 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035015396 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308 754035015397 metal binding site [ion binding]; metal-binding site 754035015398 substrate binding pocket [chemical binding]; other site 754035015399 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035015400 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035015401 active site pocket [active] 754035015402 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035015403 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035015404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035015405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015406 dimer interface [polypeptide binding]; other site 754035015407 conserved gate region; other site 754035015408 putative PBP binding loops; other site 754035015409 ABC-ATPase subunit interface; other site 754035015410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035015411 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754035015412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015413 putative PBP binding loops; other site 754035015414 dimer interface [polypeptide binding]; other site 754035015415 ABC-ATPase subunit interface; other site 754035015416 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 754035015417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035015418 Walker A/P-loop; other site 754035015419 ATP binding site [chemical binding]; other site 754035015420 Q-loop/lid; other site 754035015421 ABC transporter signature motif; other site 754035015422 Walker B; other site 754035015423 D-loop; other site 754035015424 H-loop/switch region; other site 754035015425 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035015426 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 754035015427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035015428 Walker A/P-loop; other site 754035015429 ATP binding site [chemical binding]; other site 754035015430 Q-loop/lid; other site 754035015431 ABC transporter signature motif; other site 754035015432 Walker B; other site 754035015433 D-loop; other site 754035015434 H-loop/switch region; other site 754035015435 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754035015436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035015437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754035015439 dimerization interface [polypeptide binding]; other site 754035015440 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035015441 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035015442 Domain of unknown function (DUF427); Region: DUF427; pfam04248 754035015443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 754035015444 short chain dehydrogenase; Provisional; Region: PRK06114 754035015445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035015446 NAD(P) binding site [chemical binding]; other site 754035015447 active site 754035015448 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 754035015449 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 754035015450 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 754035015451 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 754035015452 Walker A/P-loop; other site 754035015453 ATP binding site [chemical binding]; other site 754035015454 Q-loop/lid; other site 754035015455 ABC transporter signature motif; other site 754035015456 Walker B; other site 754035015457 D-loop; other site 754035015458 H-loop/switch region; other site 754035015459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015460 dimer interface [polypeptide binding]; other site 754035015461 conserved gate region; other site 754035015462 putative PBP binding loops; other site 754035015463 ABC-ATPase subunit interface; other site 754035015464 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 754035015465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015466 dimer interface [polypeptide binding]; other site 754035015467 conserved gate region; other site 754035015468 ABC-ATPase subunit interface; other site 754035015469 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 754035015470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035015471 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 754035015472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035015473 non-specific DNA binding site [nucleotide binding]; other site 754035015474 salt bridge; other site 754035015475 sequence-specific DNA binding site [nucleotide binding]; other site 754035015476 Cupin domain; Region: Cupin_2; pfam07883 754035015477 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 754035015478 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 754035015479 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 754035015480 FMN-binding pocket [chemical binding]; other site 754035015481 flavin binding motif; other site 754035015482 phosphate binding motif [ion binding]; other site 754035015483 beta-alpha-beta structure motif; other site 754035015484 NAD binding pocket [chemical binding]; other site 754035015485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035015486 catalytic loop [active] 754035015487 iron binding site [ion binding]; other site 754035015488 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035015489 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035015490 ethanolamine permease; Region: 2A0305; TIGR00908 754035015491 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 754035015492 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 754035015493 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 754035015494 putative active site [active] 754035015495 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 754035015496 domain_subunit interface; other site 754035015497 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 754035015498 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 754035015499 active site 754035015500 FMN binding site [chemical binding]; other site 754035015501 substrate binding site [chemical binding]; other site 754035015502 3Fe-4S cluster binding site [ion binding]; other site 754035015503 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 754035015504 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035015505 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 754035015506 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035015507 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 754035015508 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 754035015509 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 754035015510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035015511 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 754035015512 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 754035015513 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 754035015514 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035015515 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035015516 Amino acid permease; Region: AA_permease_2; pfam13520 754035015517 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 754035015518 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754035015519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035015520 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035015521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754035015522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754035015523 acyl-CoA synthetase; Validated; Region: PRK08162 754035015524 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 754035015525 acyl-activating enzyme (AAE) consensus motif; other site 754035015526 putative active site [active] 754035015527 AMP binding site [chemical binding]; other site 754035015528 putative CoA binding site [chemical binding]; other site 754035015529 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035015530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 754035015531 DNA binding residues [nucleotide binding] 754035015532 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035015533 short chain dehydrogenase; Validated; Region: PRK08324 754035015534 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 754035015535 active site 754035015536 intersubunit interface [polypeptide binding]; other site 754035015537 Zn2+ binding site [ion binding]; other site 754035015538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035015539 NAD(P) binding site [chemical binding]; other site 754035015540 active site 754035015541 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 754035015542 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 754035015543 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035015544 putative ligand binding site [chemical binding]; other site 754035015545 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035015546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015547 TM-ABC transporter signature motif; other site 754035015548 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035015549 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035015550 Walker A/P-loop; other site 754035015551 ATP binding site [chemical binding]; other site 754035015552 Q-loop/lid; other site 754035015553 ABC transporter signature motif; other site 754035015554 Walker B; other site 754035015555 D-loop; other site 754035015556 H-loop/switch region; other site 754035015557 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035015558 Phosphotransferase enzyme family; Region: APH; pfam01636 754035015559 serine/threonine protein kinase; Provisional; Region: PRK14879 754035015560 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 754035015561 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 754035015562 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 754035015563 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 754035015564 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 754035015565 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 754035015566 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 754035015567 dimer interface [polypeptide binding]; other site 754035015568 active site 754035015569 catalytic residue [active] 754035015570 metal binding site [ion binding]; metal-binding site 754035015571 transcriptional regulator NanR; Provisional; Region: PRK03837 754035015572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015573 DNA-binding site [nucleotide binding]; DNA binding site 754035015574 FCD domain; Region: FCD; pfam07729 754035015575 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 754035015576 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754035015577 putative ligand binding site [chemical binding]; other site 754035015578 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035015579 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035015580 Walker A/P-loop; other site 754035015581 ATP binding site [chemical binding]; other site 754035015582 Q-loop/lid; other site 754035015583 ABC transporter signature motif; other site 754035015584 Walker B; other site 754035015585 D-loop; other site 754035015586 H-loop/switch region; other site 754035015587 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035015588 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035015589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015590 TM-ABC transporter signature motif; other site 754035015591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035015592 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015593 TM-ABC transporter signature motif; other site 754035015594 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 754035015595 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035015596 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 754035015597 ligand binding site [chemical binding]; other site 754035015598 dimerization interface [polypeptide binding]; other site 754035015599 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 754035015600 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035015601 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035015602 Walker A/P-loop; other site 754035015603 ATP binding site [chemical binding]; other site 754035015604 Q-loop/lid; other site 754035015605 ABC transporter signature motif; other site 754035015606 Walker B; other site 754035015607 D-loop; other site 754035015608 H-loop/switch region; other site 754035015609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035015610 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035015611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015612 TM-ABC transporter signature motif; other site 754035015613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035015614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035015615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754035015616 transcriptional regulator NanR; Provisional; Region: PRK03837 754035015617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015618 DNA-binding site [nucleotide binding]; DNA binding site 754035015619 FCD domain; Region: FCD; pfam07729 754035015620 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 754035015621 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 754035015622 dimer interface [polypeptide binding]; other site 754035015623 active site 754035015624 catalytic residue [active] 754035015625 metal binding site [ion binding]; metal-binding site 754035015626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 754035015627 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035015628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035015629 putative DNA binding site [nucleotide binding]; other site 754035015630 putative Zn2+ binding site [ion binding]; other site 754035015631 AsnC family; Region: AsnC_trans_reg; pfam01037 754035015632 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035015633 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 754035015634 active site 754035015635 homopentamer interface [polypeptide binding]; other site 754035015636 dimer interface [polypeptide binding]; other site 754035015637 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 754035015638 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 754035015639 DAK2 domain; Region: Dak2; cl03685 754035015640 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 754035015641 triosephosphate isomerase; Provisional; Region: PRK14565 754035015642 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754035015643 substrate binding site [chemical binding]; other site 754035015644 dimer interface [polypeptide binding]; other site 754035015645 catalytic triad [active] 754035015646 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035015647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015648 DNA-binding site [nucleotide binding]; DNA binding site 754035015649 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035015650 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 754035015651 intersubunit interface [polypeptide binding]; other site 754035015652 active site 754035015653 zinc binding site [ion binding]; other site 754035015654 Na+ binding site [ion binding]; other site 754035015655 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 754035015656 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 754035015657 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 754035015658 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035015659 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 754035015660 putative ligand binding site [chemical binding]; other site 754035015661 putative NAD binding site [chemical binding]; other site 754035015662 catalytic site [active] 754035015663 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754035015664 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 754035015665 putative N- and C-terminal domain interface [polypeptide binding]; other site 754035015666 putative active site [active] 754035015667 MgATP binding site [chemical binding]; other site 754035015668 catalytic site [active] 754035015669 metal binding site [ion binding]; metal-binding site 754035015670 putative xylulose binding site [chemical binding]; other site 754035015671 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035015672 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754035015673 Walker A/P-loop; other site 754035015674 ATP binding site [chemical binding]; other site 754035015675 Q-loop/lid; other site 754035015676 ABC transporter signature motif; other site 754035015677 Walker B; other site 754035015678 D-loop; other site 754035015679 H-loop/switch region; other site 754035015680 TOBE domain; Region: TOBE_2; pfam08402 754035015681 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035015682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035015683 Walker A/P-loop; other site 754035015684 ATP binding site [chemical binding]; other site 754035015685 Q-loop/lid; other site 754035015686 ABC transporter signature motif; other site 754035015687 Walker B; other site 754035015688 D-loop; other site 754035015689 H-loop/switch region; other site 754035015690 TOBE domain; Region: TOBE_2; pfam08402 754035015691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754035015692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035015693 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035015694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015695 dimer interface [polypeptide binding]; other site 754035015696 conserved gate region; other site 754035015697 putative PBP binding loops; other site 754035015698 ABC-ATPase subunit interface; other site 754035015699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035015700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035015701 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754035015702 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754035015703 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 754035015704 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 754035015705 nucleotide binding site [chemical binding]; other site 754035015706 SulA interaction site; other site 754035015707 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035015708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015709 DNA-binding site [nucleotide binding]; DNA binding site 754035015710 FCD domain; Region: FCD; pfam07729 754035015711 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754035015712 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754035015713 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035015714 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035015715 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035015716 putative active site [active] 754035015717 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 754035015718 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 754035015719 hinge; other site 754035015720 active site 754035015721 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 754035015722 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 754035015723 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 754035015724 putative active site [active] 754035015725 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035015726 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 754035015727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035015728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015729 dimer interface [polypeptide binding]; other site 754035015730 conserved gate region; other site 754035015731 putative PBP binding loops; other site 754035015732 ABC-ATPase subunit interface; other site 754035015733 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754035015734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015735 putative PBP binding loops; other site 754035015736 dimer interface [polypeptide binding]; other site 754035015737 ABC-ATPase subunit interface; other site 754035015738 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 754035015739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035015740 Walker A/P-loop; other site 754035015741 ATP binding site [chemical binding]; other site 754035015742 Q-loop/lid; other site 754035015743 ABC transporter signature motif; other site 754035015744 Walker B; other site 754035015745 D-loop; other site 754035015746 H-loop/switch region; other site 754035015747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035015748 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035015749 Walker A/P-loop; other site 754035015750 ATP binding site [chemical binding]; other site 754035015751 Q-loop/lid; other site 754035015752 ABC transporter signature motif; other site 754035015753 Walker B; other site 754035015754 D-loop; other site 754035015755 H-loop/switch region; other site 754035015756 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035015757 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035015758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035015759 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 754035015760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035015761 Coenzyme A binding pocket [chemical binding]; other site 754035015762 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 754035015763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035015764 active site 754035015765 phosphorylation site [posttranslational modification] 754035015766 intermolecular recognition site; other site 754035015767 dimerization interface [polypeptide binding]; other site 754035015768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035015769 Walker A motif; other site 754035015770 ATP binding site [chemical binding]; other site 754035015771 Walker B motif; other site 754035015772 arginine finger; other site 754035015773 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035015774 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 754035015775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035015776 dimer interface [polypeptide binding]; other site 754035015777 phosphorylation site [posttranslational modification] 754035015778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035015779 ATP binding site [chemical binding]; other site 754035015780 Mg2+ binding site [ion binding]; other site 754035015781 G-X-G motif; other site 754035015782 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 754035015783 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 754035015784 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754035015785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754035015786 nucleotide binding site [chemical binding]; other site 754035015787 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 754035015788 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 754035015789 substrate binding site [chemical binding]; other site 754035015790 hexamer interface [polypeptide binding]; other site 754035015791 metal binding site [ion binding]; metal-binding site 754035015792 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754035015793 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754035015794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035015795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035015796 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 754035015797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035015798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015799 dimer interface [polypeptide binding]; other site 754035015800 conserved gate region; other site 754035015801 putative PBP binding loops; other site 754035015802 ABC-ATPase subunit interface; other site 754035015803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015804 dimer interface [polypeptide binding]; other site 754035015805 conserved gate region; other site 754035015806 putative PBP binding loops; other site 754035015807 ABC-ATPase subunit interface; other site 754035015808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035015809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035015810 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 754035015811 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035015812 Walker A/P-loop; other site 754035015813 ATP binding site [chemical binding]; other site 754035015814 Q-loop/lid; other site 754035015815 ABC transporter signature motif; other site 754035015816 Walker B; other site 754035015817 D-loop; other site 754035015818 H-loop/switch region; other site 754035015819 TOBE domain; Region: TOBE_2; pfam08402 754035015820 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754035015821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035015822 substrate binding site [chemical binding]; other site 754035015823 ATP binding site [chemical binding]; other site 754035015824 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 754035015825 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 754035015826 putative active site; other site 754035015827 catalytic residue [active] 754035015828 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035015829 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754035015830 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035015831 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035015832 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035015833 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 754035015834 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 754035015835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754035015836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035015837 DNA binding site [nucleotide binding] 754035015838 domain linker motif; other site 754035015839 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754035015840 dimerization interface [polypeptide binding]; other site 754035015841 ligand binding site [chemical binding]; other site 754035015842 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035015843 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754035015844 substrate binding site [chemical binding]; other site 754035015845 ATP binding site [chemical binding]; other site 754035015846 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Region: agaZ_gatZ; TIGR02810 754035015847 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 754035015848 active site 754035015849 catalytic residues [active] 754035015850 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754035015851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015852 DNA-binding site [nucleotide binding]; DNA binding site 754035015853 FCD domain; Region: FCD; pfam07729 754035015854 dihydroxy-acid dehydratase; Validated; Region: PRK06131 754035015855 short chain dehydrogenase; Provisional; Region: PRK12939 754035015856 classical (c) SDRs; Region: SDR_c; cd05233 754035015857 NAD(P) binding site [chemical binding]; other site 754035015858 active site 754035015859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 754035015860 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035015861 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035015862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754035015863 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754035015864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035015865 Walker A/P-loop; other site 754035015866 ATP binding site [chemical binding]; other site 754035015867 Q-loop/lid; other site 754035015868 ABC transporter signature motif; other site 754035015869 Walker B; other site 754035015870 D-loop; other site 754035015871 H-loop/switch region; other site 754035015872 TOBE domain; Region: TOBE_2; pfam08402 754035015873 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 754035015874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035015875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035015876 dimer interface [polypeptide binding]; other site 754035015877 conserved gate region; other site 754035015878 putative PBP binding loops; other site 754035015879 ABC-ATPase subunit interface; other site 754035015880 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754035015881 FAD binding domain; Region: FAD_binding_4; pfam01565 754035015882 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754035015883 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 754035015884 putative ligand binding site [chemical binding]; other site 754035015885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 754035015886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754035015887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754035015888 active site 754035015889 catalytic tetrad [active] 754035015890 TIGR04076 family protein; Region: TIGR04076 754035015891 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 754035015892 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035015893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015894 DNA-binding site [nucleotide binding]; DNA binding site 754035015895 FCD domain; Region: FCD; pfam07729 754035015896 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754035015897 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035015898 Walker A/P-loop; other site 754035015899 ATP binding site [chemical binding]; other site 754035015900 Q-loop/lid; other site 754035015901 ABC transporter signature motif; other site 754035015902 Walker B; other site 754035015903 D-loop; other site 754035015904 H-loop/switch region; other site 754035015905 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035015906 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035015907 Walker A/P-loop; other site 754035015908 ATP binding site [chemical binding]; other site 754035015909 Q-loop/lid; other site 754035015910 ABC transporter signature motif; other site 754035015911 Walker B; other site 754035015912 D-loop; other site 754035015913 H-loop/switch region; other site 754035015914 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015915 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035015916 TM-ABC transporter signature motif; other site 754035015917 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015918 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035015919 TM-ABC transporter signature motif; other site 754035015920 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035015921 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035015922 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035015923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035015924 DNA-binding site [nucleotide binding]; DNA binding site 754035015925 FCD domain; Region: FCD; pfam07729 754035015926 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 754035015927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035015928 inhibitor-cofactor binding pocket; inhibition site 754035015929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035015930 catalytic residue [active] 754035015931 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 754035015932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 754035015933 active site 754035015934 ATP binding site [chemical binding]; other site 754035015935 substrate binding site [chemical binding]; other site 754035015936 acetylornithine deacetylase; Provisional; Region: PRK06837 754035015937 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 754035015938 metal binding site [ion binding]; metal-binding site 754035015939 dimer interface [polypeptide binding]; other site 754035015940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035015941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035015942 Coenzyme A binding pocket [chemical binding]; other site 754035015943 AAA ATPase domain; Region: AAA_16; pfam13191 754035015944 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 754035015945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035015946 DNA binding residues [nucleotide binding] 754035015947 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 754035015948 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 754035015949 active site 754035015950 Zn binding site [ion binding]; other site 754035015951 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754035015952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035015953 TM-ABC transporter signature motif; other site 754035015954 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754035015955 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754035015956 TM-ABC transporter signature motif; other site 754035015957 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 754035015958 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754035015959 Walker A/P-loop; other site 754035015960 ATP binding site [chemical binding]; other site 754035015961 Q-loop/lid; other site 754035015962 ABC transporter signature motif; other site 754035015963 Walker B; other site 754035015964 D-loop; other site 754035015965 H-loop/switch region; other site 754035015966 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754035015967 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754035015968 Walker A/P-loop; other site 754035015969 ATP binding site [chemical binding]; other site 754035015970 Q-loop/lid; other site 754035015971 ABC transporter signature motif; other site 754035015972 Walker B; other site 754035015973 D-loop; other site 754035015974 H-loop/switch region; other site 754035015975 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 754035015976 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 754035015977 ligand binding site [chemical binding]; other site 754035015978 acetolactate synthase; Reviewed; Region: PRK08322 754035015979 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754035015980 PYR/PP interface [polypeptide binding]; other site 754035015981 dimer interface [polypeptide binding]; other site 754035015982 TPP binding site [chemical binding]; other site 754035015983 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754035015984 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 754035015985 TPP-binding site [chemical binding]; other site 754035015986 dimer interface [polypeptide binding]; other site 754035015987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035015988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035015989 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 754035015990 putative effector binding pocket; other site 754035015991 putative dimerization interface [polypeptide binding]; other site 754035015992 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 754035015993 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035015994 putative NAD(P) binding site [chemical binding]; other site 754035015995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 754035015996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 754035015997 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 754035015998 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 754035015999 active site 2 [active] 754035016000 active site 1 [active] 754035016001 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 754035016002 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754035016003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035016004 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 754035016005 Amidohydrolase; Region: Amidohydro_2; pfam04909 754035016006 active site 754035016007 Transcriptional regulator [Transcription]; Region: IclR; COG1414 754035016008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035016009 putative DNA binding site [nucleotide binding]; other site 754035016010 putative Zn2+ binding site [ion binding]; other site 754035016011 Bacterial transcriptional regulator; Region: IclR; pfam01614 754035016012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035016013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035016014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016015 dimer interface [polypeptide binding]; other site 754035016016 conserved gate region; other site 754035016017 putative PBP binding loops; other site 754035016018 ABC-ATPase subunit interface; other site 754035016019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035016020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016021 dimer interface [polypeptide binding]; other site 754035016022 conserved gate region; other site 754035016023 putative PBP binding loops; other site 754035016024 ABC-ATPase subunit interface; other site 754035016025 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035016026 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035016027 Walker A/P-loop; other site 754035016028 ATP binding site [chemical binding]; other site 754035016029 Q-loop/lid; other site 754035016030 ABC transporter signature motif; other site 754035016031 Walker B; other site 754035016032 D-loop; other site 754035016033 H-loop/switch region; other site 754035016034 TOBE domain; Region: TOBE_2; pfam08402 754035016035 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035016036 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035016037 active site pocket [active] 754035016038 Uncharacterized conserved protein [Function unknown]; Region: COG3254 754035016039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754035016040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754035016041 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 754035016042 active site 2 [active] 754035016043 active site 1 [active] 754035016044 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035016045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016046 dimer interface [polypeptide binding]; other site 754035016047 conserved gate region; other site 754035016048 putative PBP binding loops; other site 754035016049 ABC-ATPase subunit interface; other site 754035016050 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 754035016051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016052 dimer interface [polypeptide binding]; other site 754035016053 conserved gate region; other site 754035016054 putative PBP binding loops; other site 754035016055 ABC-ATPase subunit interface; other site 754035016056 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 754035016057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035016058 Walker A/P-loop; other site 754035016059 ATP binding site [chemical binding]; other site 754035016060 Q-loop/lid; other site 754035016061 ABC transporter signature motif; other site 754035016062 Walker B; other site 754035016063 D-loop; other site 754035016064 H-loop/switch region; other site 754035016065 TOBE domain; Region: TOBE_2; pfam08402 754035016066 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754035016067 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754035016068 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 754035016069 ligand binding site [chemical binding]; other site 754035016070 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035016071 NAD binding site [chemical binding]; other site 754035016072 dimerization interface [polypeptide binding]; other site 754035016073 catalytic site [active] 754035016074 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 754035016075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035016076 inhibitor-cofactor binding pocket; inhibition site 754035016077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016078 catalytic residue [active] 754035016079 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 754035016080 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 754035016081 NAD(P) binding site [chemical binding]; other site 754035016082 catalytic residues [active] 754035016083 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 754035016084 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 754035016085 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 754035016086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035016087 catalytic residue [active] 754035016088 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 754035016089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035016090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754035016091 dimerization interface [polypeptide binding]; other site 754035016092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035016093 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035016094 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035016095 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 754035016096 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035016097 FCD domain; Region: FCD; pfam07729 754035016098 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035016099 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754035016100 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035016101 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 754035016102 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 754035016103 putative active site [active] 754035016104 Zn binding site [ion binding]; other site 754035016105 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 754035016106 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035016107 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035016108 active site 754035016109 ectoine utilization protein EutC; Validated; Region: PRK08291 754035016110 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035016111 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 754035016112 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754035016113 tetramer interface [polypeptide binding]; other site 754035016114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016115 catalytic residue [active] 754035016116 ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990 754035016117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016118 dimer interface [polypeptide binding]; other site 754035016119 conserved gate region; other site 754035016120 putative PBP binding loops; other site 754035016121 ABC-ATPase subunit interface; other site 754035016122 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035016123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016124 dimer interface [polypeptide binding]; other site 754035016125 conserved gate region; other site 754035016126 putative PBP binding loops; other site 754035016127 ABC-ATPase subunit interface; other site 754035016128 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 754035016129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035016130 substrate binding pocket [chemical binding]; other site 754035016131 membrane-bound complex binding site; other site 754035016132 hinge residues; other site 754035016133 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 754035016134 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035016135 Walker A/P-loop; other site 754035016136 ATP binding site [chemical binding]; other site 754035016137 Q-loop/lid; other site 754035016138 ABC transporter signature motif; other site 754035016139 Walker B; other site 754035016140 D-loop; other site 754035016141 H-loop/switch region; other site 754035016142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035016143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035016144 DNA-binding site [nucleotide binding]; DNA binding site 754035016145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035016146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016147 homodimer interface [polypeptide binding]; other site 754035016148 catalytic residue [active] 754035016149 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035016150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035016151 putative DNA binding site [nucleotide binding]; other site 754035016152 putative Zn2+ binding site [ion binding]; other site 754035016153 AsnC family; Region: AsnC_trans_reg; pfam01037 754035016154 succinic semialdehyde dehydrogenase; Region: PLN02278 754035016155 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754035016156 tetramerization interface [polypeptide binding]; other site 754035016157 NAD(P) binding site [chemical binding]; other site 754035016158 catalytic residues [active] 754035016159 hypothetical protein; Provisional; Region: PRK07482 754035016160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035016161 inhibitor-cofactor binding pocket; inhibition site 754035016162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016163 catalytic residue [active] 754035016164 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 754035016165 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035016166 putative NAD(P) binding site [chemical binding]; other site 754035016167 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 754035016168 active sites [active] 754035016169 tetramer interface [polypeptide binding]; other site 754035016170 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754035016171 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 754035016172 NAD binding site [chemical binding]; other site 754035016173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035016174 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035016175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035016176 Walker A/P-loop; other site 754035016177 ATP binding site [chemical binding]; other site 754035016178 Q-loop/lid; other site 754035016179 ABC transporter signature motif; other site 754035016180 Walker B; other site 754035016181 D-loop; other site 754035016182 H-loop/switch region; other site 754035016183 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035016184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035016185 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 754035016186 Walker A/P-loop; other site 754035016187 ATP binding site [chemical binding]; other site 754035016188 Q-loop/lid; other site 754035016189 ABC transporter signature motif; other site 754035016190 Walker B; other site 754035016191 D-loop; other site 754035016192 H-loop/switch region; other site 754035016193 putative transporter; Provisional; Region: PRK10504 754035016194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035016195 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 754035016196 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754035016197 Walker A/P-loop; other site 754035016198 ATP binding site [chemical binding]; other site 754035016199 Q-loop/lid; other site 754035016200 ABC transporter signature motif; other site 754035016201 Walker B; other site 754035016202 D-loop; other site 754035016203 H-loop/switch region; other site 754035016204 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754035016205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016206 dimer interface [polypeptide binding]; other site 754035016207 conserved gate region; other site 754035016208 putative PBP binding loops; other site 754035016209 ABC-ATPase subunit interface; other site 754035016210 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 754035016211 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 754035016212 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 754035016213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035016214 DNA-binding site [nucleotide binding]; DNA binding site 754035016215 UTRA domain; Region: UTRA; pfam07702 754035016216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754035016217 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035016218 NAD(P) binding site [chemical binding]; other site 754035016219 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 754035016220 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 754035016221 NAD binding site [chemical binding]; other site 754035016222 dimerization interface [polypeptide binding]; other site 754035016223 product binding site; other site 754035016224 substrate binding site [chemical binding]; other site 754035016225 zinc binding site [ion binding]; other site 754035016226 catalytic residues [active] 754035016227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035016228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754035016229 NAD(P) binding site [chemical binding]; other site 754035016230 active site 754035016231 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754035016232 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035016233 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 754035016234 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754035016235 short chain dehydrogenase; Provisional; Region: PRK06701 754035016236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035016237 NAD(P) binding site [chemical binding]; other site 754035016238 active site 754035016239 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 754035016240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035016241 active site 754035016242 motif I; other site 754035016243 motif II; other site 754035016244 AAA ATPase domain; Region: AAA_16; pfam13191 754035016245 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 754035016246 Walker A motif; other site 754035016247 ATP binding site [chemical binding]; other site 754035016248 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 754035016249 trimer interface [polypeptide binding]; other site 754035016250 putative Zn binding site [ion binding]; other site 754035016251 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 754035016252 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 754035016253 active site 754035016254 DNA binding site [nucleotide binding] 754035016255 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 754035016256 DNA binding site [nucleotide binding] 754035016257 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 754035016258 dimerization interface [polypeptide binding]; other site 754035016259 metal binding site [ion binding]; metal-binding site 754035016260 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 754035016261 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 754035016262 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 754035016263 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 754035016264 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 754035016265 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 754035016266 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754035016267 catalytic loop [active] 754035016268 iron binding site [ion binding]; other site 754035016269 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 754035016270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 754035016271 Protein of unknown function (DUF768); Region: DUF768; pfam05589 754035016272 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 754035016273 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 754035016274 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035016275 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035016276 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754035016277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035016278 putative substrate translocation pore; other site 754035016279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035016280 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 754035016281 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754035016282 active site 754035016283 metal binding site [ion binding]; metal-binding site 754035016284 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 754035016285 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035016286 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 754035016287 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 754035016288 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 754035016289 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 754035016290 classical (c) SDRs; Region: SDR_c; cd05233 754035016291 NAD(P) binding site [chemical binding]; other site 754035016292 active site 754035016293 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 754035016294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754035016295 NAD binding site [chemical binding]; other site 754035016296 catalytic Zn binding site [ion binding]; other site 754035016297 structural Zn binding site [ion binding]; other site 754035016298 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035016299 CheB methylesterase; Region: CheB_methylest; pfam01339 754035016300 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 754035016301 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 754035016302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016303 S-adenosylmethionine binding site [chemical binding]; other site 754035016304 PAS domain; Region: PAS_10; pfam13596 754035016305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754035016306 HWE histidine kinase; Region: HWE_HK; smart00911 754035016307 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035016308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035016309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035016310 NAD(P) binding site [chemical binding]; other site 754035016311 active site 754035016312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035016313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035016314 NAD(P) binding site [chemical binding]; other site 754035016315 active site 754035016316 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 754035016317 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 754035016318 B12 binding site [chemical binding]; other site 754035016319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035016320 FeS/SAM binding site; other site 754035016321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754035016322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035016323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 754035016324 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 754035016325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 754035016326 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 754035016327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 754035016328 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754035016329 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 754035016330 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 754035016331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754035016332 NAD binding site [chemical binding]; other site 754035016333 putative substrate binding site 2 [chemical binding]; other site 754035016334 putative substrate binding site 1 [chemical binding]; other site 754035016335 active site 754035016336 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 754035016337 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 754035016338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754035016339 catalytic core [active] 754035016340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 754035016341 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 754035016342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754035016343 active site 754035016344 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035016345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016346 S-adenosylmethionine binding site [chemical binding]; other site 754035016347 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 754035016348 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 754035016349 putative ADP-binding pocket [chemical binding]; other site 754035016350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754035016351 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 754035016352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 754035016353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016354 S-adenosylmethionine binding site [chemical binding]; other site 754035016355 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 754035016356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754035016357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754035016358 DNA binding residues [nucleotide binding] 754035016359 hydroperoxidase II; Provisional; Region: katE; PRK11249 754035016360 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 754035016361 heme binding pocket [chemical binding]; other site 754035016362 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 754035016363 domain interactions; other site 754035016364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035016365 TPR motif; other site 754035016366 binding surface 754035016367 Tetratricopeptide repeat; Region: TPR_12; pfam13424 754035016368 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 754035016369 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035016370 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754035016371 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035016372 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 754035016373 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754035016374 ATP binding site [chemical binding]; other site 754035016375 Walker A motif; other site 754035016376 hexamer interface [polypeptide binding]; other site 754035016377 Walker B motif; other site 754035016378 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 754035016379 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 754035016380 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 754035016381 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 754035016382 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754035016383 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 754035016384 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035016385 TadE-like protein; Region: TadE; pfam07811 754035016386 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035016387 TadE-like protein; Region: TadE; pfam07811 754035016388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 754035016389 active site 754035016390 phosphorylation site [posttranslational modification] 754035016391 intermolecular recognition site; other site 754035016392 dimerization interface [polypeptide binding]; other site 754035016393 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754035016394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754035016395 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754035016396 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754035016397 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 754035016398 succinic semialdehyde dehydrogenase; Region: PLN02278 754035016399 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754035016400 tetramerization interface [polypeptide binding]; other site 754035016401 NAD(P) binding site [chemical binding]; other site 754035016402 catalytic residues [active] 754035016403 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 754035016404 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 754035016405 putative active site [active] 754035016406 metal binding site [ion binding]; metal-binding site 754035016407 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035016408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035016409 DNA-binding site [nucleotide binding]; DNA binding site 754035016410 FCD domain; Region: FCD; pfam07729 754035016411 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035016412 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035016413 Walker A/P-loop; other site 754035016414 ATP binding site [chemical binding]; other site 754035016415 Q-loop/lid; other site 754035016416 ABC transporter signature motif; other site 754035016417 Walker B; other site 754035016418 D-loop; other site 754035016419 H-loop/switch region; other site 754035016420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035016421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035016422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035016423 TM-ABC transporter signature motif; other site 754035016424 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035016425 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 754035016426 putative ligand binding site [chemical binding]; other site 754035016427 intracellular protease, PfpI family; Region: PfpI; TIGR01382 754035016428 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 754035016429 conserved cys residue [active] 754035016430 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035016431 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035016432 active site pocket [active] 754035016433 NIPSNAP; Region: NIPSNAP; pfam07978 754035016434 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 754035016435 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035016436 active site pocket [active] 754035016437 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035016438 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035016439 active site pocket [active] 754035016440 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035016441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035016442 DNA-binding site [nucleotide binding]; DNA binding site 754035016443 FCD domain; Region: FCD; pfam07729 754035016444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754035016445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754035016446 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754035016447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016448 dimer interface [polypeptide binding]; other site 754035016449 conserved gate region; other site 754035016450 putative PBP binding loops; other site 754035016451 ABC-ATPase subunit interface; other site 754035016452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754035016453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016454 dimer interface [polypeptide binding]; other site 754035016455 conserved gate region; other site 754035016456 putative PBP binding loops; other site 754035016457 ABC-ATPase subunit interface; other site 754035016458 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754035016459 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754035016460 Walker A/P-loop; other site 754035016461 ATP binding site [chemical binding]; other site 754035016462 Q-loop/lid; other site 754035016463 ABC transporter signature motif; other site 754035016464 Walker B; other site 754035016465 D-loop; other site 754035016466 H-loop/switch region; other site 754035016467 TOBE domain; Region: TOBE; pfam03459 754035016468 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035016469 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 754035016470 active site pocket [active] 754035016471 hypothetical protein; Validated; Region: PRK08245 754035016472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035016473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035016474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035016475 dimerization interface [polypeptide binding]; other site 754035016476 short chain dehydrogenase; Provisional; Region: PRK06500 754035016477 classical (c) SDRs; Region: SDR_c; cd05233 754035016478 NAD(P) binding site [chemical binding]; other site 754035016479 active site 754035016480 short chain dehydrogenase; Provisional; Region: PRK06500 754035016481 classical (c) SDRs; Region: SDR_c; cd05233 754035016482 NAD(P) binding site [chemical binding]; other site 754035016483 active site 754035016484 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 754035016485 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 754035016486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016487 S-adenosylmethionine binding site [chemical binding]; other site 754035016488 ribonuclease Z; Region: RNase_Z; TIGR02651 754035016489 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 754035016490 active site 754035016491 metal binding site [ion binding]; metal-binding site 754035016492 homotetramer interface [polypeptide binding]; other site 754035016493 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754035016494 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754035016495 HlyD family secretion protein; Region: HlyD_3; pfam13437 754035016496 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 754035016497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035016498 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 754035016499 Walker A/P-loop; other site 754035016500 ATP binding site [chemical binding]; other site 754035016501 Q-loop/lid; other site 754035016502 ABC transporter signature motif; other site 754035016503 Walker B; other site 754035016504 D-loop; other site 754035016505 H-loop/switch region; other site 754035016506 VCBS repeat; Region: VCBS_repeat; TIGR01965 754035016507 VCBS repeat; Region: VCBS_repeat; TIGR01965 754035016508 VCBS repeat; Region: VCBS_repeat; TIGR01965 754035016509 Phosphopantetheine attachment site; Region: PP-binding; cl09936 754035016510 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035016511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035016512 non-specific DNA binding site [nucleotide binding]; other site 754035016513 salt bridge; other site 754035016514 sequence-specific DNA binding site [nucleotide binding]; other site 754035016515 Domain of unknown function (DUF955); Region: DUF955; pfam06114 754035016516 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 754035016517 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 754035016518 active site 754035016519 thymidylate synthase; Provisional; Region: thyA; PRK00956 754035016520 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754035016521 trimer interface [polypeptide binding]; other site 754035016522 active site 754035016523 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 754035016524 putative metal binding site [ion binding]; other site 754035016525 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 754035016526 putative uracil binding site [chemical binding]; other site 754035016527 putative active site [active] 754035016528 hypothetical protein; Provisional; Region: PRK09126 754035016529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754035016530 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 754035016531 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 754035016532 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754035016533 metal-binding site [ion binding] 754035016534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754035016535 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754035016536 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 754035016537 FixH; Region: FixH; pfam05751 754035016538 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 754035016539 4Fe-4S binding domain; Region: Fer4_5; pfam12801 754035016540 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 754035016541 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 754035016542 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 754035016543 Cytochrome c; Region: Cytochrom_C; pfam00034 754035016544 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 754035016545 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 754035016546 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 754035016547 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 754035016548 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 754035016549 Low-spin heme binding site [chemical binding]; other site 754035016550 Putative water exit pathway; other site 754035016551 Binuclear center (active site) [active] 754035016552 Putative proton exit pathway; other site 754035016553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035016554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754035016555 ligand binding site [chemical binding]; other site 754035016556 flexible hinge region; other site 754035016557 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754035016558 putative switch regulator; other site 754035016559 non-specific DNA interactions [nucleotide binding]; other site 754035016560 DNA binding site [nucleotide binding] 754035016561 sequence specific DNA binding site [nucleotide binding]; other site 754035016562 putative cAMP binding site [chemical binding]; other site 754035016563 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 754035016564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035016565 FeS/SAM binding site; other site 754035016566 HemN C-terminal domain; Region: HemN_C; pfam06969 754035016567 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 754035016568 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 754035016569 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 754035016570 VirB7 interaction site; other site 754035016571 conjugal transfer protein TrbF; Provisional; Region: PRK13872 754035016572 conjugal transfer protein TrbL; Provisional; Region: PRK13875 754035016573 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 754035016574 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 754035016575 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 754035016576 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 754035016577 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 754035016578 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 754035016579 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 754035016580 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 754035016581 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 754035016582 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754035016583 ATP binding site [chemical binding]; other site 754035016584 Walker A motif; other site 754035016585 hexamer interface [polypeptide binding]; other site 754035016586 Walker B motif; other site 754035016587 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 754035016588 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 754035016589 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754035016590 Walker A motif; other site 754035016591 ATP binding site [chemical binding]; other site 754035016592 Walker B motif; other site 754035016593 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 754035016594 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 754035016595 glutaminase active site [active] 754035016596 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754035016597 dimer interface [polypeptide binding]; other site 754035016598 active site 754035016599 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754035016600 dimer interface [polypeptide binding]; other site 754035016601 active site 754035016602 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 754035016603 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 754035016604 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 754035016605 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035016606 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035016607 catalytic residue [active] 754035016608 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 754035016609 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 754035016610 Helix-turn-helix domain; Region: HTH_17; pfam12728 754035016611 Uncharacterized conserved protein [Function unknown]; Region: COG5489 754035016612 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754035016613 ParB-like nuclease domain; Region: ParB; smart00470 754035016614 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 754035016615 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 754035016616 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 754035016617 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 754035016618 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754035016619 catalytic residues [active] 754035016620 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 754035016621 Protein of unknown function (DUF982); Region: DUF982; pfam06169 754035016622 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 754035016623 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 754035016624 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 754035016625 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 754035016626 active site 754035016627 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 754035016628 Ligand Binding Site [chemical binding]; other site 754035016629 Helix-turn-helix; Region: HTH_3; pfam01381 754035016630 non-specific DNA binding site [nucleotide binding]; other site 754035016631 salt bridge; other site 754035016632 sequence-specific DNA binding site [nucleotide binding]; other site 754035016633 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 754035016634 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 754035016635 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 754035016636 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 754035016637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754035016638 active site 754035016639 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 754035016640 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 754035016641 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035016642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035016643 DNA binding residues [nucleotide binding] 754035016644 dimerization interface [polypeptide binding]; other site 754035016645 Pantoate-beta-alanine ligase; Region: PanC; cd00560 754035016646 pantoate--beta-alanine ligase; Region: panC; TIGR00018 754035016647 active site 754035016648 ATP-binding site [chemical binding]; other site 754035016649 pantoate-binding site; other site 754035016650 HXXH motif; other site 754035016651 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 754035016652 oligomerization interface [polypeptide binding]; other site 754035016653 active site 754035016654 metal binding site [ion binding]; metal-binding site 754035016655 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 754035016656 quinolinate synthetase; Provisional; Region: PRK09375 754035016657 L-aspartate oxidase; Provisional; Region: PRK07512 754035016658 L-aspartate oxidase; Provisional; Region: PRK06175 754035016659 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754035016660 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 754035016661 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 754035016662 dimerization interface [polypeptide binding]; other site 754035016663 active site 754035016664 biotin synthase; Region: bioB; TIGR00433 754035016665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035016666 FeS/SAM binding site; other site 754035016667 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 754035016668 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 754035016669 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 754035016670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035016671 catalytic residue [active] 754035016672 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 754035016673 AAA domain; Region: AAA_26; pfam13500 754035016674 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 754035016675 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035016676 inhibitor-cofactor binding pocket; inhibition site 754035016677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016678 catalytic residue [active] 754035016679 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 754035016680 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754035016681 dimer interface [polypeptide binding]; other site 754035016682 active site 754035016683 CoA binding pocket [chemical binding]; other site 754035016684 Transmembrane secretion effector; Region: MFS_3; pfam05977 754035016685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035016686 HipA N-terminal domain; Region: Couple_hipA; cl11853 754035016687 HipA-like N-terminal domain; Region: HipA_N; pfam07805 754035016688 HipA-like C-terminal domain; Region: HipA_C; pfam07804 754035016689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035016690 non-specific DNA binding site [nucleotide binding]; other site 754035016691 salt bridge; other site 754035016692 sequence-specific DNA binding site [nucleotide binding]; other site 754035016693 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 754035016694 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 754035016695 active site 754035016696 zinc binding site [ion binding]; other site 754035016697 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 754035016698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035016699 dimer interface [polypeptide binding]; other site 754035016700 phosphorylation site [posttranslational modification] 754035016701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035016702 ATP binding site [chemical binding]; other site 754035016703 Mg2+ binding site [ion binding]; other site 754035016704 G-X-G motif; other site 754035016705 type IV secretion system protein VirB11; Provisional; Region: PRK13851 754035016706 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754035016707 Walker A motif; other site 754035016708 hexamer interface [polypeptide binding]; other site 754035016709 ATP binding site [chemical binding]; other site 754035016710 Walker B motif; other site 754035016711 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 754035016712 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 754035016713 VirB7 interaction site; other site 754035016714 type IV secretion system protein VirB8; Provisional; Region: PRK13865 754035016715 type IV secretion system protein VirB6; Provisional; Region: PRK13852 754035016716 type IV secretion system protein VirB5; Provisional; Region: PRK13860 754035016717 type IV secretion system protein VirB4; Provisional; Region: PRK13853 754035016718 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 754035016719 type IV secretion system protein VirB3; Provisional; Region: PRK13854 754035016720 TrbC/VIRB2 family; Region: TrbC; cl01583 754035016721 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754035016722 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754035016723 catalytic residue [active] 754035016724 two-component response regulator VirG; Provisional; Region: PRK13856 754035016725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035016726 active site 754035016727 phosphorylation site [posttranslational modification] 754035016728 intermolecular recognition site; other site 754035016729 dimerization interface [polypeptide binding]; other site 754035016730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035016731 DNA binding site [nucleotide binding] 754035016732 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 754035016733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754035016734 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 754035016735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754035016736 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 754035016737 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 754035016738 Walker A motif; other site 754035016739 ATP binding site [chemical binding]; other site 754035016740 Walker B motif; other site 754035016741 RNA silencing suppressor P21; Region: Suppressor_P21; pfam11479 754035016742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035016743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035016744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035016745 dimerization interface [polypeptide binding]; other site 754035016746 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 754035016747 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 754035016748 putative active site [active] 754035016749 putative metal binding site [ion binding]; other site 754035016750 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 754035016751 amidohydrolase; Region: amidohydrolases; TIGR01891 754035016752 putative metal binding site [ion binding]; other site 754035016753 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 754035016754 alanine racemase; Reviewed; Region: alr; PRK00053 754035016755 active site 754035016756 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035016757 dimer interface [polypeptide binding]; other site 754035016758 substrate binding site [chemical binding]; other site 754035016759 catalytic residues [active] 754035016760 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 754035016761 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035016762 Walker A/P-loop; other site 754035016763 ATP binding site [chemical binding]; other site 754035016764 Q-loop/lid; other site 754035016765 ABC transporter signature motif; other site 754035016766 Walker B; other site 754035016767 D-loop; other site 754035016768 H-loop/switch region; other site 754035016769 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 754035016770 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035016771 substrate binding pocket [chemical binding]; other site 754035016772 membrane-bound complex binding site; other site 754035016773 hinge residues; other site 754035016774 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035016775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016776 dimer interface [polypeptide binding]; other site 754035016777 conserved gate region; other site 754035016778 putative PBP binding loops; other site 754035016779 ABC-ATPase subunit interface; other site 754035016780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016781 dimer interface [polypeptide binding]; other site 754035016782 conserved gate region; other site 754035016783 putative PBP binding loops; other site 754035016784 ABC-ATPase subunit interface; other site 754035016785 Arginase family; Region: Arginase; cd09989 754035016786 active site 754035016787 Mn binding site [ion binding]; other site 754035016788 oligomer interface [polypeptide binding]; other site 754035016789 ornithine cyclodeaminase; Validated; Region: PRK07589 754035016790 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 754035016791 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 754035016792 Amidinotransferase; Region: Amidinotransf; pfam02274 754035016793 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 754035016794 Amidinotransferase; Region: Amidinotransf; cl12043 754035016795 Predicted methyltransferase [General function prediction only]; Region: COG3897 754035016796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016797 S-adenosylmethionine binding site [chemical binding]; other site 754035016798 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754035016799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035016800 S-adenosylmethionine binding site [chemical binding]; other site 754035016801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 754035016802 non-specific DNA binding site [nucleotide binding]; other site 754035016803 salt bridge; other site 754035016804 sequence-specific DNA binding site [nucleotide binding]; other site 754035016805 HipA-like N-terminal domain; Region: HipA_N; pfam07805 754035016806 HipA-like C-terminal domain; Region: HipA_C; pfam07804 754035016807 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 754035016808 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 754035016809 dimer interface [polypeptide binding]; other site 754035016810 active site 754035016811 glycine-pyridoxal phosphate binding site [chemical binding]; other site 754035016812 folate binding site [chemical binding]; other site 754035016813 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 754035016814 S-adenosylmethionine synthetase; Validated; Region: PRK05250 754035016815 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 754035016816 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 754035016817 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 754035016818 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754035016819 substrate binding site [chemical binding]; other site 754035016820 ATP binding site [chemical binding]; other site 754035016821 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 754035016822 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754035016823 NAD(P) binding site [chemical binding]; other site 754035016824 Predicted transcriptional regulator [Transcription]; Region: COG4957 754035016825 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 754035016826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035016827 FeS/SAM binding site; other site 754035016828 HemN C-terminal domain; Region: HemN_C; pfam06969 754035016829 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754035016830 DNA-binding site [nucleotide binding]; DNA binding site 754035016831 RNA-binding motif; other site 754035016832 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754035016833 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754035016834 Cytochrome P450; Region: p450; cl12078 754035016835 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 754035016836 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 754035016837 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754035016838 Cytochrome P450; Region: p450; cl12078 754035016839 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754035016840 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754035016841 substrate binding pocket [chemical binding]; other site 754035016842 chain length determination region; other site 754035016843 substrate-Mg2+ binding site; other site 754035016844 catalytic residues [active] 754035016845 aspartate-rich region 1; other site 754035016846 active site lid residues [active] 754035016847 aspartate-rich region 2; other site 754035016848 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 754035016849 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 754035016850 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 754035016851 substrate binding pocket [chemical binding]; other site 754035016852 substrate-Mg2+ binding site; other site 754035016853 aspartate-rich region 1; other site 754035016854 aspartate-rich region 2; other site 754035016855 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 754035016856 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 754035016857 homotetramer interface [polypeptide binding]; other site 754035016858 FMN binding site [chemical binding]; other site 754035016859 homodimer contacts [polypeptide binding]; other site 754035016860 putative active site [active] 754035016861 putative substrate binding site [chemical binding]; other site 754035016862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035016863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035016864 active site 754035016865 phosphorylation site [posttranslational modification] 754035016866 intermolecular recognition site; other site 754035016867 dimerization interface [polypeptide binding]; other site 754035016868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035016869 DNA binding site [nucleotide binding] 754035016870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035016871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035016872 ATP binding site [chemical binding]; other site 754035016873 Mg2+ binding site [ion binding]; other site 754035016874 G-X-G motif; other site 754035016875 HipA N-terminal domain; Region: Couple_hipA; cl11853 754035016876 HipA-like N-terminal domain; Region: HipA_N; pfam07805 754035016877 HipA-like C-terminal domain; Region: HipA_C; pfam07804 754035016878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754035016879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035016880 non-specific DNA binding site [nucleotide binding]; other site 754035016881 salt bridge; other site 754035016882 sequence-specific DNA binding site [nucleotide binding]; other site 754035016883 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 754035016884 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754035016885 succinic semialdehyde dehydrogenase; Region: PLN02278 754035016886 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754035016887 tetramerization interface [polypeptide binding]; other site 754035016888 NAD(P) binding site [chemical binding]; other site 754035016889 catalytic residues [active] 754035016890 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 754035016891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035016892 active site 754035016893 motif I; other site 754035016894 motif II; other site 754035016895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754035016896 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 754035016897 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035016898 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 754035016899 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754035016900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035016901 non-specific DNA binding site [nucleotide binding]; other site 754035016902 salt bridge; other site 754035016903 sequence-specific DNA binding site [nucleotide binding]; other site 754035016904 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035016905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035016906 DNA binding residues [nucleotide binding] 754035016907 dimerization interface [polypeptide binding]; other site 754035016908 hypothetical protein; Provisional; Region: PRK07482 754035016909 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035016910 inhibitor-cofactor binding pocket; inhibition site 754035016911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035016912 catalytic residue [active] 754035016913 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 754035016914 ATP binding site [chemical binding]; other site 754035016915 substrate interface [chemical binding]; other site 754035016916 ThiF family; Region: ThiF; pfam00899 754035016917 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 754035016918 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754035016919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754035016920 putative DNA binding site [nucleotide binding]; other site 754035016921 putative Zn2+ binding site [ion binding]; other site 754035016922 AsnC family; Region: AsnC_trans_reg; pfam01037 754035016923 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 754035016924 Fumarase C-terminus; Region: Fumerase_C; pfam05683 754035016925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035016926 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754035016927 tetramerization interface [polypeptide binding]; other site 754035016928 NAD(P) binding site [chemical binding]; other site 754035016929 catalytic residues [active] 754035016930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035016931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035016932 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 754035016933 putative dimerization interface [polypeptide binding]; other site 754035016934 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 754035016935 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 754035016936 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754035016937 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 754035016938 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 754035016939 dimer interface [polypeptide binding]; other site 754035016940 active site 754035016941 Homeodomain-like domain; Region: HTH_23; cl17451 754035016942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 754035016943 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754035016944 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 754035016945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754035016946 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 754035016947 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 754035016948 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 754035016949 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 754035016950 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 754035016951 putative active site [active] 754035016952 putative metal binding site [ion binding]; other site 754035016953 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 754035016954 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 754035016955 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035016956 Walker A/P-loop; other site 754035016957 ATP binding site [chemical binding]; other site 754035016958 Q-loop/lid; other site 754035016959 ABC transporter signature motif; other site 754035016960 Walker B; other site 754035016961 D-loop; other site 754035016962 H-loop/switch region; other site 754035016963 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754035016964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 754035016965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035016966 Walker A/P-loop; other site 754035016967 ATP binding site [chemical binding]; other site 754035016968 Q-loop/lid; other site 754035016969 ABC transporter signature motif; other site 754035016970 Walker B; other site 754035016971 D-loop; other site 754035016972 H-loop/switch region; other site 754035016973 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754035016974 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754035016975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016976 putative PBP binding loops; other site 754035016977 dimer interface [polypeptide binding]; other site 754035016978 ABC-ATPase subunit interface; other site 754035016979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035016980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035016981 dimer interface [polypeptide binding]; other site 754035016982 conserved gate region; other site 754035016983 putative PBP binding loops; other site 754035016984 ABC-ATPase subunit interface; other site 754035016985 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035016986 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 754035016987 Beta-lactamase; Region: Beta-lactamase; pfam00144 754035016988 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754035016989 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754035016990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 754035016991 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 754035016992 Predicted deacylase [General function prediction only]; Region: COG3608 754035016993 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 754035016994 active site 754035016995 Zn binding site [ion binding]; other site 754035016996 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754035016997 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754035016998 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 754035016999 active site 754035017000 hypothetical protein; Provisional; Region: PRK07475 754035017001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035017002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035017003 substrate binding pocket [chemical binding]; other site 754035017004 membrane-bound complex binding site; other site 754035017005 hinge residues; other site 754035017006 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035017007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035017008 dimer interface [polypeptide binding]; other site 754035017009 conserved gate region; other site 754035017010 putative PBP binding loops; other site 754035017011 ABC-ATPase subunit interface; other site 754035017012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035017013 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035017014 Walker A/P-loop; other site 754035017015 ATP binding site [chemical binding]; other site 754035017016 Q-loop/lid; other site 754035017017 ABC transporter signature motif; other site 754035017018 Walker B; other site 754035017019 D-loop; other site 754035017020 H-loop/switch region; other site 754035017021 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 754035017022 putative active site [active] 754035017023 Zn binding site [ion binding]; other site 754035017024 Predicted acyl esterases [General function prediction only]; Region: COG2936 754035017025 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 754035017026 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 754035017027 Amidase; Region: Amidase; cl11426 754035017028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035017029 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 754035017030 Walker A/P-loop; other site 754035017031 ATP binding site [chemical binding]; other site 754035017032 Q-loop/lid; other site 754035017033 ABC transporter signature motif; other site 754035017034 Walker B; other site 754035017035 D-loop; other site 754035017036 H-loop/switch region; other site 754035017037 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754035017038 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 754035017039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754035017040 Walker A/P-loop; other site 754035017041 ATP binding site [chemical binding]; other site 754035017042 Q-loop/lid; other site 754035017043 ABC transporter signature motif; other site 754035017044 Walker B; other site 754035017045 D-loop; other site 754035017046 H-loop/switch region; other site 754035017047 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754035017048 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 754035017049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754035017050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035017051 putative PBP binding loops; other site 754035017052 dimer interface [polypeptide binding]; other site 754035017053 ABC-ATPase subunit interface; other site 754035017054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754035017055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035017056 dimer interface [polypeptide binding]; other site 754035017057 conserved gate region; other site 754035017058 putative PBP binding loops; other site 754035017059 ABC-ATPase subunit interface; other site 754035017060 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754035017061 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 754035017062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035017063 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754035017064 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 754035017065 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035017066 inhibitor-cofactor binding pocket; inhibition site 754035017067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017068 catalytic residue [active] 754035017069 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754035017070 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035017071 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 754035017072 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754035017073 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754035017074 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754035017075 Walker A/P-loop; other site 754035017076 ATP binding site [chemical binding]; other site 754035017077 Q-loop/lid; other site 754035017078 ABC transporter signature motif; other site 754035017079 Walker B; other site 754035017080 D-loop; other site 754035017081 H-loop/switch region; other site 754035017082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754035017083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035017084 dimer interface [polypeptide binding]; other site 754035017085 conserved gate region; other site 754035017086 putative PBP binding loops; other site 754035017087 ABC-ATPase subunit interface; other site 754035017088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754035017089 dimer interface [polypeptide binding]; other site 754035017090 conserved gate region; other site 754035017091 putative PBP binding loops; other site 754035017092 ABC-ATPase subunit interface; other site 754035017093 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035017094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035017095 substrate binding pocket [chemical binding]; other site 754035017096 membrane-bound complex binding site; other site 754035017097 hinge residues; other site 754035017098 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 754035017099 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754035017100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754035017101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754035017102 putative active site [active] 754035017103 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 754035017104 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 754035017105 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 754035017106 conserved cys residue [active] 754035017107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754035017108 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 754035017109 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 754035017110 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754035017111 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 754035017112 putative NAD(P) binding site [chemical binding]; other site 754035017113 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754035017114 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754035017115 metal binding site [ion binding]; metal-binding site 754035017116 substrate binding pocket [chemical binding]; other site 754035017117 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 754035017118 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754035017119 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 754035017120 NAD(P) binding site [chemical binding]; other site 754035017121 catalytic residues [active] 754035017122 catalytic residues [active] 754035017123 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 754035017124 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 754035017125 [2Fe-2S] cluster binding site [ion binding]; other site 754035017126 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 754035017127 hydrophobic ligand binding site; other site 754035017128 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 754035017129 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754035017130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754035017131 S-adenosylmethionine binding site [chemical binding]; other site 754035017132 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 754035017133 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754035017134 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 754035017135 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754035017136 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 754035017137 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 754035017138 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 754035017139 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 754035017140 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 754035017141 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 754035017142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035017143 inhibitor-cofactor binding pocket; inhibition site 754035017144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017145 catalytic residue [active] 754035017146 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 754035017147 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 754035017148 acyl-activating enzyme (AAE) consensus motif; other site 754035017149 AMP binding site [chemical binding]; other site 754035017150 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 754035017151 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 754035017152 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 754035017153 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754035017154 DNA-binding interface [nucleotide binding]; DNA binding site 754035017155 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035017156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035017157 DNA binding residues [nucleotide binding] 754035017158 dimerization interface [polypeptide binding]; other site 754035017159 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 754035017160 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 754035017161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017162 catalytic residue [active] 754035017163 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 754035017164 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 754035017165 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 754035017166 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035017167 catalytic residues [active] 754035017168 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 754035017169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754035017170 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035017171 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754035017172 Ligand Binding Site [chemical binding]; other site 754035017173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754035017174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754035017175 DNA binding site [nucleotide binding] 754035017176 probable nitrogen fixation protein; Region: TIGR02935 754035017177 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 754035017178 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 754035017179 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 754035017180 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 754035017181 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 754035017182 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 754035017183 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 754035017184 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 754035017185 MoFe protein beta/alpha subunit interactions; other site 754035017186 Beta subunit P cluster binding residues; other site 754035017187 MoFe protein beta subunit/Fe protein contacts; other site 754035017188 MoFe protein dimer/ dimer interactions; other site 754035017189 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 754035017190 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 754035017191 MoFe protein alpha/beta subunit interactions; other site 754035017192 Alpha subunit P cluster binding residues; other site 754035017193 FeMoco binding residues [chemical binding]; other site 754035017194 MoFe protein alpha subunit/Fe protein contacts; other site 754035017195 MoFe protein dimer/ dimer interactions; other site 754035017196 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 754035017197 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 754035017198 Nucleotide-binding sites [chemical binding]; other site 754035017199 Walker A motif; other site 754035017200 Switch I region of nucleotide binding site; other site 754035017201 Fe4S4 binding sites [ion binding]; other site 754035017202 Switch II region of nucleotide binding site; other site 754035017203 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754035017204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754035017205 putative substrate translocation pore; other site 754035017206 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 754035017207 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754035017208 catalytic triad [active] 754035017209 dimer interface [polypeptide binding]; other site 754035017210 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 754035017211 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 754035017212 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 754035017213 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 754035017214 NifQ; Region: NifQ; pfam04891 754035017215 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 754035017216 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 754035017217 short chain dehydrogenase; Validated; Region: PRK06484 754035017218 classical (c) SDRs; Region: SDR_c; cd05233 754035017219 NAD(P) binding site [chemical binding]; other site 754035017220 active site 754035017221 classical (c) SDRs; Region: SDR_c; cd05233 754035017222 NAD(P) binding site [chemical binding]; other site 754035017223 active site 754035017224 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 754035017225 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754035017226 Cytochrome P450; Region: p450; cl12078 754035017227 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 754035017228 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754035017229 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754035017230 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 754035017231 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 754035017232 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 754035017233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754035017234 catalytic residue [active] 754035017235 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 754035017236 active site 754035017237 catalytic residues [active] 754035017238 metal binding site [ion binding]; metal-binding site 754035017239 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 754035017240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 754035017241 Ligand binding site [chemical binding]; other site 754035017242 Electron transfer flavoprotein domain; Region: ETF; pfam01012 754035017243 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 754035017244 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 754035017245 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754035017246 oxidoreductase; Provisional; Region: PRK10015 754035017247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754035017248 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 754035017249 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 754035017250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754035017251 FeS/SAM binding site; other site 754035017252 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 754035017253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754035017254 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 754035017255 NifZ domain; Region: NifZ; pfam04319 754035017256 NifT/FixU protein; Region: NifT; pfam06988 754035017257 SIR2-like domain; Region: SIR2_2; pfam13289 754035017258 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035017259 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035017260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754035017261 Walker A/P-loop; other site 754035017262 ATP binding site [chemical binding]; other site 754035017263 Q-loop/lid; other site 754035017264 ABC transporter signature motif; other site 754035017265 Walker B; other site 754035017266 D-loop; other site 754035017267 H-loop/switch region; other site 754035017268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754035017269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754035017270 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 754035017271 Walker A/P-loop; other site 754035017272 ATP binding site [chemical binding]; other site 754035017273 Q-loop/lid; other site 754035017274 ABC transporter signature motif; other site 754035017275 Walker B; other site 754035017276 D-loop; other site 754035017277 H-loop/switch region; other site 754035017278 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 754035017279 Nif-specific regulatory protein; Region: nifA; TIGR01817 754035017280 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754035017281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754035017282 Walker A motif; other site 754035017283 ATP binding site [chemical binding]; other site 754035017284 Walker B motif; other site 754035017285 arginine finger; other site 754035017286 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754035017287 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 754035017288 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 754035017289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754035017290 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754035017291 DNA binding site [nucleotide binding] 754035017292 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 754035017293 putative ligand binding site [chemical binding]; other site 754035017294 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 754035017295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035017296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035017297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035017298 dimerization interface [polypeptide binding]; other site 754035017299 Nodulation protein A (NodA); Region: NodA; pfam02474 754035017300 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 754035017301 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 754035017302 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754035017303 dimer interface [polypeptide binding]; other site 754035017304 active site 754035017305 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 754035017306 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 754035017307 NAD(P) binding site [chemical binding]; other site 754035017308 homotetramer interface [polypeptide binding]; other site 754035017309 homodimer interface [polypeptide binding]; other site 754035017310 active site 754035017311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035017312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035017313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035017314 N-acyltransferase NodA; Region: nodulat_NodA; TIGR04245 754035017315 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 754035017316 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 754035017317 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 754035017318 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 754035017319 DXD motif; other site 754035017320 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 754035017321 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 754035017322 Walker A/P-loop; other site 754035017323 ATP binding site [chemical binding]; other site 754035017324 Q-loop/lid; other site 754035017325 ABC transporter signature motif; other site 754035017326 Walker B; other site 754035017327 D-loop; other site 754035017328 H-loop/switch region; other site 754035017329 ABC-2 type transporter; Region: ABC2_membrane; cl17235 754035017330 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754035017331 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 754035017332 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 754035017333 Transposase; Region: HTH_Tnp_1; pfam01527 754035017334 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 754035017335 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 754035017336 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 754035017337 B3/4 domain; Region: B3_4; pfam03483 754035017338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035017339 DNA-binding site [nucleotide binding]; DNA binding site 754035017340 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754035017341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035017342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017343 homodimer interface [polypeptide binding]; other site 754035017344 catalytic residue [active] 754035017345 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754035017346 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 754035017347 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 754035017348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754035017349 non-specific DNA binding site [nucleotide binding]; other site 754035017350 salt bridge; other site 754035017351 sequence-specific DNA binding site [nucleotide binding]; other site 754035017352 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754035017353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754035017354 DNA-binding site [nucleotide binding]; DNA binding site 754035017355 FCD domain; Region: FCD; pfam07729 754035017356 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 754035017357 dimer interface [polypeptide binding]; other site 754035017358 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 754035017359 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 754035017360 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 754035017361 CHAT domain; Region: CHAT; cl17868 754035017362 CHAT domain; Region: CHAT; cl17868 754035017363 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 754035017364 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 754035017365 Caspase domain; Region: Peptidase_C14; pfam00656 754035017366 ski2-like helicase; Provisional; Region: PRK00254 754035017367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035017368 ATP binding site [chemical binding]; other site 754035017369 putative Mg++ binding site [ion binding]; other site 754035017370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035017371 nucleotide binding region [chemical binding]; other site 754035017372 ATP-binding site [chemical binding]; other site 754035017373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 754035017374 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 754035017375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754035017376 Coenzyme A binding pocket [chemical binding]; other site 754035017377 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754035017378 catalytic residue [active] 754035017379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754035017380 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754035017381 oligomerisation interface [polypeptide binding]; other site 754035017382 mobile loop; other site 754035017383 roof hairpin; other site 754035017384 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754035017385 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754035017386 ring oligomerisation interface [polypeptide binding]; other site 754035017387 ATP/Mg binding site [chemical binding]; other site 754035017388 stacking interactions; other site 754035017389 hinge regions; other site 754035017390 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 754035017391 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754035017392 ADP binding site [chemical binding]; other site 754035017393 magnesium binding site [ion binding]; other site 754035017394 putative shikimate binding site; other site 754035017395 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754035017396 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754035017397 catalytic residues [active] 754035017398 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 754035017399 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754035017400 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 754035017401 ABC-ATPase subunit interface; other site 754035017402 dimer interface [polypeptide binding]; other site 754035017403 putative PBP binding regions; other site 754035017404 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754035017405 ABC-ATPase subunit interface; other site 754035017406 dimer interface [polypeptide binding]; other site 754035017407 putative PBP binding regions; other site 754035017408 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 754035017409 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754035017410 siderophore binding site; other site 754035017411 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 754035017412 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 754035017413 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 754035017414 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 754035017415 short chain dehydrogenase; Validated; Region: PRK08324 754035017416 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 754035017417 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 754035017418 putative NAD(P) binding site [chemical binding]; other site 754035017419 active site 754035017420 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754035017421 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754035017422 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754035017423 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 754035017424 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 754035017425 ligand binding site [chemical binding]; other site 754035017426 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754035017427 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035017428 Walker A/P-loop; other site 754035017429 ATP binding site [chemical binding]; other site 754035017430 Q-loop/lid; other site 754035017431 ABC transporter signature motif; other site 754035017432 Walker B; other site 754035017433 D-loop; other site 754035017434 H-loop/switch region; other site 754035017435 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035017436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035017437 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035017438 TM-ABC transporter signature motif; other site 754035017439 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035017440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035017441 TM-ABC transporter signature motif; other site 754035017442 Domain of unknown function (DUF718); Region: DUF718; pfam05336 754035017443 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754035017444 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 754035017445 N- and C-terminal domain interface [polypeptide binding]; other site 754035017446 putative active site [active] 754035017447 putative MgATP binding site [chemical binding]; other site 754035017448 putative catalytic site [active] 754035017449 metal binding site [ion binding]; metal-binding site 754035017450 putative carbohydrate binding site [chemical binding]; other site 754035017451 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 754035017452 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 754035017453 active site 754035017454 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754035017455 dimer interface [polypeptide binding]; other site 754035017456 substrate binding site [chemical binding]; other site 754035017457 catalytic residue [active] 754035017458 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 754035017459 metal binding site [ion binding]; metal-binding site 754035017460 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 754035017461 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754035017462 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754035017463 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 754035017464 NAD binding site [chemical binding]; other site 754035017465 homodimer interface [polypeptide binding]; other site 754035017466 active site 754035017467 substrate binding site [chemical binding]; other site 754035017468 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754035017469 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754035017470 substrate-cofactor binding pocket; other site 754035017471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017472 catalytic residue [active] 754035017473 aspartate aminotransferase; Provisional; Region: PRK06108 754035017474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754035017475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017476 homodimer interface [polypeptide binding]; other site 754035017477 catalytic residue [active] 754035017478 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 754035017479 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 754035017480 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 754035017481 Na binding site [ion binding]; other site 754035017482 PAS fold; Region: PAS_7; pfam12860 754035017483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754035017484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035017485 dimer interface [polypeptide binding]; other site 754035017486 phosphorylation site [posttranslational modification] 754035017487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035017488 ATP binding site [chemical binding]; other site 754035017489 Mg2+ binding site [ion binding]; other site 754035017490 G-X-G motif; other site 754035017491 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754035017492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035017493 active site 754035017494 phosphorylation site [posttranslational modification] 754035017495 intermolecular recognition site; other site 754035017496 dimerization interface [polypeptide binding]; other site 754035017497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754035017498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754035017499 active site 754035017500 phosphorylation site [posttranslational modification] 754035017501 intermolecular recognition site; other site 754035017502 dimerization interface [polypeptide binding]; other site 754035017503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035017504 DNA binding residues [nucleotide binding] 754035017505 dimerization interface [polypeptide binding]; other site 754035017506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 754035017507 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 754035017508 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 754035017509 quinone interaction residues [chemical binding]; other site 754035017510 active site 754035017511 catalytic residues [active] 754035017512 FMN binding site [chemical binding]; other site 754035017513 substrate binding site [chemical binding]; other site 754035017514 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 754035017515 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 754035017516 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 754035017517 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 754035017518 putative active site [active] 754035017519 Zn binding site [ion binding]; other site 754035017520 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754035017521 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 754035017522 Ligand binding site; other site 754035017523 Putative Catalytic site; other site 754035017524 DXD motif; other site 754035017525 Predicted membrane protein [Function unknown]; Region: COG2246 754035017526 GtrA-like protein; Region: GtrA; pfam04138 754035017527 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 754035017528 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 754035017529 additional DNA contacts [nucleotide binding]; other site 754035017530 mismatch recognition site; other site 754035017531 active site 754035017532 zinc binding site [ion binding]; other site 754035017533 DNA intercalation site [nucleotide binding]; other site 754035017534 AAA-like domain; Region: AAA_10; pfam12846 754035017535 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 754035017536 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754035017537 DNA binding site [nucleotide binding] 754035017538 substrate interaction site [chemical binding]; other site 754035017539 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754035017540 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 754035017541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035017542 ATP binding site [chemical binding]; other site 754035017543 putative Mg++ binding site [ion binding]; other site 754035017544 helicase superfamily c-terminal domain; Region: HELICc; smart00490 754035017545 nucleotide binding region [chemical binding]; other site 754035017546 ATP-binding site [chemical binding]; other site 754035017547 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754035017548 putative active site pocket [active] 754035017549 dimerization interface [polypeptide binding]; other site 754035017550 putative catalytic residue [active] 754035017551 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754035017552 nucleotide binding site [chemical binding]; other site 754035017553 ParB-like nuclease domain; Region: ParBc; pfam02195 754035017554 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754035017555 RepB plasmid partitioning protein; Region: RepB; pfam07506 754035017556 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754035017557 ParB-like nuclease domain; Region: ParB; smart00470 754035017558 RepB plasmid partitioning protein; Region: RepB; pfam07506 754035017559 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754035017560 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754035017561 catalytic residues [active] 754035017562 catalytic nucleophile [active] 754035017563 Recombinase; Region: Recombinase; pfam07508 754035017564 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 754035017565 Bacterial TniB protein; Region: TniB; pfam05621 754035017566 AAA domain; Region: AAA_22; pfam13401 754035017567 TniQ; Region: TniQ; pfam06527 754035017568 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 754035017569 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 754035017570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035017571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035017572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754035017573 dimerization interface [polypeptide binding]; other site 754035017574 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 754035017575 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 754035017576 putative ligand binding site [chemical binding]; other site 754035017577 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 754035017578 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754035017579 Walker A/P-loop; other site 754035017580 ATP binding site [chemical binding]; other site 754035017581 Q-loop/lid; other site 754035017582 ABC transporter signature motif; other site 754035017583 Walker B; other site 754035017584 D-loop; other site 754035017585 H-loop/switch region; other site 754035017586 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754035017587 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035017588 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754035017589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754035017590 TM-ABC transporter signature motif; other site 754035017591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 754035017592 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754035017593 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 754035017594 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 754035017595 trimer interface [polypeptide binding]; other site 754035017596 active site 754035017597 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 754035017598 trimer interface [polypeptide binding]; other site 754035017599 active site 754035017600 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 754035017601 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754035017602 homodimer interface [polypeptide binding]; other site 754035017603 substrate-cofactor binding pocket; other site 754035017604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017605 catalytic residue [active] 754035017606 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 754035017607 ligand binding site; other site 754035017608 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 754035017609 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 754035017610 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 754035017611 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 754035017612 dimerization interface [polypeptide binding]; other site 754035017613 domain crossover interface; other site 754035017614 redox-dependent activation switch; other site 754035017615 ornithine carbamoyltransferase; Provisional; Region: PRK00779 754035017616 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754035017617 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754035017618 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 754035017619 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754035017620 inhibitor-cofactor binding pocket; inhibition site 754035017621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754035017622 catalytic residue [active] 754035017623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 754035017624 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 754035017625 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 754035017626 oligomer interface [polypeptide binding]; other site 754035017627 metal binding site [ion binding]; metal-binding site 754035017628 metal binding site [ion binding]; metal-binding site 754035017629 putative Cl binding site [ion binding]; other site 754035017630 basic sphincter; other site 754035017631 hydrophobic gate; other site 754035017632 periplasmic entrance; other site 754035017633 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 754035017634 PhoU domain; Region: PhoU; pfam01895 754035017635 PhoU domain; Region: PhoU; pfam01895 754035017636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754035017637 dimer interface [polypeptide binding]; other site 754035017638 phosphorylation site [posttranslational modification] 754035017639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754035017640 ATP binding site [chemical binding]; other site 754035017641 Mg2+ binding site [ion binding]; other site 754035017642 G-X-G motif; other site 754035017643 Uncharacterized conserved protein [Function unknown]; Region: COG2326 754035017644 enoyl-CoA hydratase; Provisional; Region: PRK06688 754035017645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035017646 substrate binding site [chemical binding]; other site 754035017647 oxyanion hole (OAH) forming residues; other site 754035017648 trimer interface [polypeptide binding]; other site 754035017649 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 754035017650 Autoinducer binding domain; Region: Autoind_bind; pfam03472 754035017651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754035017652 DNA binding residues [nucleotide binding] 754035017653 dimerization interface [polypeptide binding]; other site 754035017654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754035017655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754035017656 substrate binding pocket [chemical binding]; other site 754035017657 membrane-bound complex binding site; other site 754035017658 hinge residues; other site 754035017659 tellurite resistance protein terB; Region: terB; cd07176 754035017660 putative metal binding site [ion binding]; other site 754035017661 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 754035017662 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 754035017663 active site 754035017664 HIGH motif; other site 754035017665 KMSKS motif; other site 754035017666 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 754035017667 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 754035017668 Catalytic site; other site 754035017669 Predicted transcriptional regulator [Transcription]; Region: COG2932 754035017670 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754035017671 Catalytic site [active] 754035017672 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 754035017673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035017674 substrate binding site [chemical binding]; other site 754035017675 oxyanion hole (OAH) forming residues; other site 754035017676 trimer interface [polypeptide binding]; other site 754035017677 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754035017678 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035017679 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754035017680 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 754035017681 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754035017682 dimer interface [polypeptide binding]; other site 754035017683 active site 754035017684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754035017685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 754035017686 active site 754035017687 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 754035017688 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 754035017689 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 754035017690 FAD binding site [chemical binding]; other site 754035017691 substrate binding site [chemical binding]; other site 754035017692 catalytic residues [active] 754035017693 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 754035017694 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 754035017695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754035017696 DNA binding residues [nucleotide binding] 754035017697 putative dimer interface [polypeptide binding]; other site 754035017698 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 754035017699 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754035017700 Sel1-like repeats; Region: SEL1; smart00671 754035017701 Sel1-like repeats; Region: SEL1; smart00671 754035017702 Sel1-like repeats; Region: SEL1; smart00671 754035017703 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 754035017704 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754035017705 Predicted permeases [General function prediction only]; Region: COG0730 754035017706 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 754035017707 putative chaperone; Provisional; Region: PRK11678 754035017708 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 754035017709 nucleotide binding site [chemical binding]; other site 754035017710 putative NEF/HSP70 interaction site [polypeptide binding]; other site 754035017711 SBD interface [polypeptide binding]; other site 754035017712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754035017713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754035017714 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 754035017715 putative dimerization interface [polypeptide binding]; other site 754035017716 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 754035017717 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754035017718 molybdopterin cofactor binding site; other site 754035017719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754035017720 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 754035017721 putative molybdopterin cofactor binding site; other site 754035017722 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 754035017723 4Fe-4S binding domain; Region: Fer4; pfam00037 754035017724 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 754035017725 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754035017726 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 754035017727 putative active site [active] 754035017728 putative metal binding site [ion binding]; other site 754035017729 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 754035017730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754035017731 ATP binding site [chemical binding]; other site 754035017732 putative Mg++ binding site [ion binding]; other site 754035017733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754035017734 nucleotide binding region [chemical binding]; other site 754035017735 ATP-binding site [chemical binding]; other site 754035017736 DEAD/H associated; Region: DEAD_assoc; pfam08494 754035017737 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 754035017738 NlpC/P60 family; Region: NLPC_P60; cl17555 754035017739 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754035017740 MarR family; Region: MarR; pfam01047 754035017741 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 754035017742 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754035017743 interface (dimer of trimers) [polypeptide binding]; other site 754035017744 Substrate-binding/catalytic site; other site 754035017745 Zn-binding sites [ion binding]; other site 754035017746 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 754035017747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035017748 binding surface 754035017749 TPR motif; other site 754035017750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754035017751 TPR motif; other site 754035017752 binding surface 754035017753 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 754035017754 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035017755 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754035017756 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754035017757 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 754035017758 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754035017759 ATP binding site [chemical binding]; other site 754035017760 Walker A motif; other site 754035017761 hexamer interface [polypeptide binding]; other site 754035017762 Walker B motif; other site 754035017763 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 754035017764 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 754035017765 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 754035017766 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 754035017767 Type IV pili component [Cell motility and secretion]; Region: COG5461 754035017768 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 754035017769 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 754035017770 BON domain; Region: BON; pfam04972 754035017771 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754035017772 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 754035017773 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 754035017774 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 754035017775 Flp/Fap pilin component; Region: Flp_Fap; cl01585 754035017776 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 754035017777 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035017778 TadE-like protein; Region: TadE; pfam07811 754035017779 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 754035017780 TadE-like protein; Region: TadE; pfam07811 754035017781 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 754035017782 phosphopentomutase; Provisional; Region: PRK05362 754035017783 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 754035017784 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 754035017785 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 754035017786 DNA binding site [nucleotide binding] 754035017787 catalytic residue [active] 754035017788 H2TH interface [polypeptide binding]; other site 754035017789 putative catalytic residues [active] 754035017790 turnover-facilitating residue; other site 754035017791 intercalation triad [nucleotide binding]; other site 754035017792 8OG recognition residue [nucleotide binding]; other site 754035017793 putative reading head residues; other site 754035017794 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754035017795 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754035017796 enoyl-CoA hydratase; Provisional; Region: PRK05862 754035017797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754035017798 substrate binding site [chemical binding]; other site 754035017799 oxyanion hole (OAH) forming residues; other site 754035017800 trimer interface [polypeptide binding]; other site 754035017801 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239