-- dump date 20140619_141109 -- class Genbank::misc_feature -- table misc_feature_note -- id note 536019000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 536019000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 536019000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 536019000004 Walker A motif; other site 536019000005 ATP binding site [chemical binding]; other site 536019000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 536019000007 DnaA box-binding interface [nucleotide binding]; other site 536019000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 536019000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 536019000010 putative DNA binding surface [nucleotide binding]; other site 536019000011 dimer interface [polypeptide binding]; other site 536019000012 beta-clamp/clamp loader binding surface; other site 536019000013 beta-clamp/translesion DNA polymerase binding surface; other site 536019000014 recombination protein F; Reviewed; Region: recF; PRK00064 536019000015 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 536019000016 Walker A/P-loop; other site 536019000017 ATP binding site [chemical binding]; other site 536019000018 Q-loop/lid; other site 536019000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019000020 ABC transporter signature motif; other site 536019000021 Walker B; other site 536019000022 D-loop; other site 536019000023 H-loop/switch region; other site 536019000024 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 536019000025 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 536019000026 ATP binding site [chemical binding]; other site 536019000027 substrate interface [chemical binding]; other site 536019000028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536019000029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019000030 Coenzyme A binding pocket [chemical binding]; other site 536019000031 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 536019000032 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 536019000033 dimerization interface [polypeptide binding]; other site 536019000034 ligand binding site [chemical binding]; other site 536019000035 NADP binding site [chemical binding]; other site 536019000036 catalytic site [active] 536019000037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 536019000038 Bacterial SH3 domain; Region: SH3_4; pfam06347 536019000039 Bacterial SH3 domain; Region: SH3_4; pfam06347 536019000040 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 536019000041 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 536019000042 metal binding site 2 [ion binding]; metal-binding site 536019000043 putative DNA binding helix; other site 536019000044 metal binding site 1 [ion binding]; metal-binding site 536019000045 dimer interface [polypeptide binding]; other site 536019000046 structural Zn2+ binding site [ion binding]; other site 536019000047 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 536019000048 active site 1 [active] 536019000049 dimer interface [polypeptide binding]; other site 536019000050 active site 2 [active] 536019000051 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 536019000052 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019000053 dimer interface [polypeptide binding]; other site 536019000054 active site 536019000055 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 536019000056 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 536019000057 NAD binding site [chemical binding]; other site 536019000058 homotetramer interface [polypeptide binding]; other site 536019000059 homodimer interface [polypeptide binding]; other site 536019000060 substrate binding site [chemical binding]; other site 536019000061 active site 536019000062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019000063 metal binding site [ion binding]; metal-binding site 536019000064 active site 536019000065 I-site; other site 536019000066 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019000067 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 536019000068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019000069 S-adenosylmethionine binding site [chemical binding]; other site 536019000070 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 536019000071 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 536019000072 RNase E interface [polypeptide binding]; other site 536019000073 trimer interface [polypeptide binding]; other site 536019000074 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 536019000075 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 536019000076 RNase E interface [polypeptide binding]; other site 536019000077 trimer interface [polypeptide binding]; other site 536019000078 active site 536019000079 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 536019000080 putative nucleic acid binding region [nucleotide binding]; other site 536019000081 G-X-X-G motif; other site 536019000082 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 536019000083 RNA binding site [nucleotide binding]; other site 536019000084 domain interface; other site 536019000085 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 536019000086 16S/18S rRNA binding site [nucleotide binding]; other site 536019000087 S13e-L30e interaction site [polypeptide binding]; other site 536019000088 25S rRNA binding site [nucleotide binding]; other site 536019000089 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536019000090 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 536019000091 oligomer interface [polypeptide binding]; other site 536019000092 metal binding site [ion binding]; metal-binding site 536019000093 metal binding site [ion binding]; metal-binding site 536019000094 Cl binding site [ion binding]; other site 536019000095 aspartate ring; other site 536019000096 basic sphincter; other site 536019000097 putative hydrophobic gate; other site 536019000098 periplasmic entrance; other site 536019000099 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 536019000100 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 536019000101 RNA binding site [nucleotide binding]; other site 536019000102 active site 536019000103 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 536019000104 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 536019000105 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 536019000106 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 536019000107 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 536019000108 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 536019000109 G1 box; other site 536019000110 putative GEF interaction site [polypeptide binding]; other site 536019000111 GTP/Mg2+ binding site [chemical binding]; other site 536019000112 Switch I region; other site 536019000113 G2 box; other site 536019000114 G3 box; other site 536019000115 Switch II region; other site 536019000116 G4 box; other site 536019000117 G5 box; other site 536019000118 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 536019000119 Translation-initiation factor 2; Region: IF-2; pfam11987 536019000120 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 536019000121 hypothetical protein; Provisional; Region: PRK09190 536019000122 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 536019000123 putative RNA binding cleft [nucleotide binding]; other site 536019000124 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 536019000125 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 536019000126 NusA N-terminal domain; Region: NusA_N; pfam08529 536019000127 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 536019000128 RNA binding site [nucleotide binding]; other site 536019000129 homodimer interface [polypeptide binding]; other site 536019000130 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 536019000131 G-X-X-G motif; other site 536019000132 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 536019000133 G-X-X-G motif; other site 536019000134 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 536019000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 536019000136 Sm and related proteins; Region: Sm_like; cl00259 536019000137 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 536019000138 putative oligomer interface [polypeptide binding]; other site 536019000139 putative RNA binding site [nucleotide binding]; other site 536019000140 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 536019000141 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 536019000142 S-adenosylmethionine synthetase; Validated; Region: PRK05250 536019000143 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 536019000144 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 536019000145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019000146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019000147 non-specific DNA binding site [nucleotide binding]; other site 536019000148 salt bridge; other site 536019000149 sequence-specific DNA binding site [nucleotide binding]; other site 536019000150 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 536019000151 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 536019000152 putative active site [active] 536019000153 catalytic triad [active] 536019000154 putative dimer interface [polypeptide binding]; other site 536019000155 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 536019000156 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019000157 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 536019000158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536019000159 Transporter associated domain; Region: CorC_HlyC; smart01091 536019000160 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 536019000161 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 536019000162 PhoH-like protein; Region: PhoH; pfam02562 536019000163 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 536019000164 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 536019000165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019000166 FeS/SAM binding site; other site 536019000167 TRAM domain; Region: TRAM; pfam01938 536019000168 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 536019000169 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 536019000170 putative acyl-acceptor binding pocket; other site 536019000171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019000172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019000173 Coenzyme A binding pocket [chemical binding]; other site 536019000174 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 536019000175 Glycoprotease family; Region: Peptidase_M22; pfam00814 536019000176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 536019000177 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 536019000178 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 536019000179 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 536019000180 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 536019000181 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 536019000182 heme binding site [chemical binding]; other site 536019000183 ferroxidase pore; other site 536019000184 ferroxidase diiron center [ion binding]; other site 536019000185 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 536019000186 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 536019000187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019000188 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 536019000189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019000190 inhibitor-cofactor binding pocket; inhibition site 536019000191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019000192 catalytic residue [active] 536019000193 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019000194 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019000195 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019000196 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019000197 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019000198 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019000199 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019000200 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019000201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000202 Walker A/P-loop; other site 536019000203 ATP binding site [chemical binding]; other site 536019000204 Q-loop/lid; other site 536019000205 ABC transporter signature motif; other site 536019000206 Walker B; other site 536019000207 D-loop; other site 536019000208 H-loop/switch region; other site 536019000209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019000210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000211 Walker A/P-loop; other site 536019000212 ATP binding site [chemical binding]; other site 536019000213 Q-loop/lid; other site 536019000214 ABC transporter signature motif; other site 536019000215 Walker B; other site 536019000216 D-loop; other site 536019000217 H-loop/switch region; other site 536019000218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019000219 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000221 dimer interface [polypeptide binding]; other site 536019000222 conserved gate region; other site 536019000223 ABC-ATPase subunit interface; other site 536019000224 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000226 dimer interface [polypeptide binding]; other site 536019000227 conserved gate region; other site 536019000228 putative PBP binding loops; other site 536019000229 ABC-ATPase subunit interface; other site 536019000230 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019000231 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 536019000232 lytic murein transglycosylase; Region: MltB_2; TIGR02283 536019000233 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019000234 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019000235 catalytic residue [active] 536019000236 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019000237 recombination protein RecR; Reviewed; Region: recR; PRK00076 536019000238 RecR protein; Region: RecR; pfam02132 536019000239 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 536019000240 putative active site [active] 536019000241 putative metal-binding site [ion binding]; other site 536019000242 tetramer interface [polypeptide binding]; other site 536019000243 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 536019000244 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 536019000245 hypothetical protein; Validated; Region: PRK00153 536019000246 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 536019000247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019000248 Walker A motif; other site 536019000249 ATP binding site [chemical binding]; other site 536019000250 Walker B motif; other site 536019000251 arginine finger; other site 536019000252 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 536019000253 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 536019000254 HIT domain; Region: HIT; pfam01230 536019000255 nucleotide binding site/active site [active] 536019000256 HIT family signature motif; other site 536019000257 catalytic residue [active] 536019000258 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 536019000259 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 536019000260 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 536019000261 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 536019000262 putative NADH binding site [chemical binding]; other site 536019000263 putative active site [active] 536019000264 nudix motif; other site 536019000265 putative metal binding site [ion binding]; other site 536019000266 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 536019000267 prephenate dehydratase; Provisional; Region: PRK11899 536019000268 Prephenate dehydratase; Region: PDT; pfam00800 536019000269 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 536019000270 putative L-Phe binding site [chemical binding]; other site 536019000271 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 536019000272 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 536019000273 Ligand binding site; other site 536019000274 oligomer interface; other site 536019000275 Cytochrome c2 [Energy production and conversion]; Region: COG3474 536019000276 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 536019000277 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 536019000278 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 536019000279 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 536019000280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 536019000281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000282 dimer interface [polypeptide binding]; other site 536019000283 conserved gate region; other site 536019000284 putative PBP binding loops; other site 536019000285 ABC-ATPase subunit interface; other site 536019000286 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 536019000287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000288 dimer interface [polypeptide binding]; other site 536019000289 conserved gate region; other site 536019000290 putative PBP binding loops; other site 536019000291 ABC-ATPase subunit interface; other site 536019000292 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 536019000293 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000294 Walker A/P-loop; other site 536019000295 ATP binding site [chemical binding]; other site 536019000296 Q-loop/lid; other site 536019000297 ABC transporter signature motif; other site 536019000298 Walker B; other site 536019000299 D-loop; other site 536019000300 H-loop/switch region; other site 536019000301 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536019000302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000303 Walker A/P-loop; other site 536019000304 ATP binding site [chemical binding]; other site 536019000305 Q-loop/lid; other site 536019000306 ABC transporter signature motif; other site 536019000307 Walker B; other site 536019000308 D-loop; other site 536019000309 H-loop/switch region; other site 536019000310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019000311 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019000312 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 536019000313 putative ligand binding site [chemical binding]; other site 536019000314 NAD binding site [chemical binding]; other site 536019000315 dimerization interface [polypeptide binding]; other site 536019000316 catalytic site [active] 536019000317 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 536019000318 AAA domain; Region: AAA_17; pfam13207 536019000319 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 536019000320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019000321 S-adenosylmethionine binding site [chemical binding]; other site 536019000322 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 536019000323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019000324 ATP-dependent DNA ligase; Validated; Region: PRK09247 536019000325 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 536019000326 active site 536019000327 DNA binding site [nucleotide binding] 536019000328 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 536019000329 DNA binding site [nucleotide binding] 536019000330 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 536019000331 EF-hand domain pair; Region: EF_hand_5; pfam13499 536019000332 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 536019000333 Ca2+ binding site [ion binding]; other site 536019000334 RNA polymerase sigma factor; Reviewed; Region: PRK05602 536019000335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019000336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019000337 DNA binding residues [nucleotide binding] 536019000338 Predicted integral membrane protein [Function unknown]; Region: COG5612 536019000339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 536019000340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 536019000341 Sulfatase; Region: Sulfatase; cl17466 536019000342 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 536019000343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 536019000344 putative acyl-acceptor binding pocket; other site 536019000345 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 536019000346 acyl-activating enzyme (AAE) consensus motif; other site 536019000347 putative AMP binding site [chemical binding]; other site 536019000348 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 536019000349 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 536019000350 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 536019000351 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 536019000352 PYR/PP interface [polypeptide binding]; other site 536019000353 dimer interface [polypeptide binding]; other site 536019000354 TPP binding site [chemical binding]; other site 536019000355 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 536019000356 TPP-binding site; other site 536019000357 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019000358 MarR family; Region: MarR_2; pfam12802 536019000359 MarR family; Region: MarR_2; cl17246 536019000360 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 536019000361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019000362 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 536019000363 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 536019000364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019000365 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 536019000366 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 536019000367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019000368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000369 ABC-ATPase subunit interface; other site 536019000370 putative PBP binding loops; other site 536019000371 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000373 dimer interface [polypeptide binding]; other site 536019000374 conserved gate region; other site 536019000375 putative PBP binding loops; other site 536019000376 ABC-ATPase subunit interface; other site 536019000377 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000378 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 536019000379 Walker A/P-loop; other site 536019000380 ATP binding site [chemical binding]; other site 536019000381 Q-loop/lid; other site 536019000382 ABC transporter signature motif; other site 536019000383 Walker B; other site 536019000384 D-loop; other site 536019000385 H-loop/switch region; other site 536019000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536019000387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019000389 Walker A/P-loop; other site 536019000390 ATP binding site [chemical binding]; other site 536019000391 Q-loop/lid; other site 536019000392 ABC transporter signature motif; other site 536019000393 Walker B; other site 536019000394 D-loop; other site 536019000395 H-loop/switch region; other site 536019000396 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019000397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019000398 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019000399 active site 536019000400 metal binding site [ion binding]; metal-binding site 536019000401 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 536019000402 hypothetical protein; Provisional; Region: PRK07236 536019000403 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019000404 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 536019000405 active site 536019000406 FMN binding site [chemical binding]; other site 536019000407 substrate binding site [chemical binding]; other site 536019000408 homotetramer interface [polypeptide binding]; other site 536019000409 catalytic residue [active] 536019000410 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019000411 classical (c) SDRs; Region: SDR_c; cd05233 536019000412 NAD(P) binding site [chemical binding]; other site 536019000413 active site 536019000414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019000415 MarR family; Region: MarR; pfam01047 536019000416 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 536019000417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019000418 substrate binding site [chemical binding]; other site 536019000419 oxyanion hole (OAH) forming residues; other site 536019000420 trimer interface [polypeptide binding]; other site 536019000421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019000422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 536019000423 active site 536019000424 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019000425 homotrimer interaction site [polypeptide binding]; other site 536019000426 putative active site [active] 536019000427 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 536019000428 active site 536019000429 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 536019000430 dimer interface [polypeptide binding]; other site 536019000431 non-prolyl cis peptide bond; other site 536019000432 insertion regions; other site 536019000433 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 536019000434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019000435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019000436 substrate binding pocket [chemical binding]; other site 536019000437 membrane-bound complex binding site; other site 536019000438 hinge residues; other site 536019000439 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 536019000440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000441 putative PBP binding loops; other site 536019000442 dimer interface [polypeptide binding]; other site 536019000443 ABC-ATPase subunit interface; other site 536019000444 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 536019000445 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 536019000446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019000447 catalytic residue [active] 536019000448 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019000449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000450 Walker A/P-loop; other site 536019000451 ATP binding site [chemical binding]; other site 536019000452 Q-loop/lid; other site 536019000453 ABC transporter signature motif; other site 536019000454 Walker B; other site 536019000455 D-loop; other site 536019000456 H-loop/switch region; other site 536019000457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019000458 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019000459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019000460 Walker A/P-loop; other site 536019000461 ATP binding site [chemical binding]; other site 536019000462 Q-loop/lid; other site 536019000463 ABC transporter signature motif; other site 536019000464 Walker B; other site 536019000465 D-loop; other site 536019000466 H-loop/switch region; other site 536019000467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019000468 dipeptide transporter; Provisional; Region: PRK10913 536019000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000470 dimer interface [polypeptide binding]; other site 536019000471 conserved gate region; other site 536019000472 putative PBP binding loops; other site 536019000473 ABC-ATPase subunit interface; other site 536019000474 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019000475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000476 dimer interface [polypeptide binding]; other site 536019000477 conserved gate region; other site 536019000478 putative PBP binding loops; other site 536019000479 ABC-ATPase subunit interface; other site 536019000480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019000481 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 536019000482 peptide binding site [polypeptide binding]; other site 536019000483 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 536019000484 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 536019000485 acyl-activating enzyme (AAE) consensus motif; other site 536019000486 putative AMP binding site [chemical binding]; other site 536019000487 putative active site [active] 536019000488 putative CoA binding site [chemical binding]; other site 536019000489 Predicted methyltransferase [General function prediction only]; Region: COG3897 536019000490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019000491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019000492 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019000493 putative effector binding pocket; other site 536019000494 dimerization interface [polypeptide binding]; other site 536019000495 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019000496 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019000497 putative NAD(P) binding site [chemical binding]; other site 536019000498 Uncharacterized conserved protein [Function unknown]; Region: COG1359 536019000499 major facilitator superfamily transporter; Provisional; Region: PRK05122 536019000500 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 536019000501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019000502 motif II; other site 536019000503 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 536019000504 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 536019000505 active site 536019000506 dimer interface [polypeptide binding]; other site 536019000507 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 536019000508 dimer interface [polypeptide binding]; other site 536019000509 active site 536019000510 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536019000511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019000512 DNA-binding site [nucleotide binding]; DNA binding site 536019000513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019000514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019000515 homodimer interface [polypeptide binding]; other site 536019000516 catalytic residue [active] 536019000517 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 536019000518 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 536019000519 Chromate transporter; Region: Chromate_transp; cl17781 536019000520 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 536019000521 active site residue [active] 536019000522 Uncharacterized conserved protein [Function unknown]; Region: COG4275 536019000523 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 536019000524 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 536019000525 putative hydrophobic ligand binding site [chemical binding]; other site 536019000526 Domain of unknown function DUF59; Region: DUF59; pfam01883 536019000527 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 536019000528 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 536019000529 Walker A motif; other site 536019000530 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019000531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019000532 active site 536019000533 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536019000534 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 536019000535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019000536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019000537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536019000538 dimerization interface [polypeptide binding]; other site 536019000539 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 536019000540 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 536019000541 putative dimer interface [polypeptide binding]; other site 536019000542 [2Fe-2S] cluster binding site [ion binding]; other site 536019000543 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 536019000544 putative dimer interface [polypeptide binding]; other site 536019000545 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 536019000546 SLBB domain; Region: SLBB; pfam10531 536019000547 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 536019000548 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 536019000549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019000550 catalytic loop [active] 536019000551 iron binding site [ion binding]; other site 536019000552 4Fe-4S binding domain; Region: Fer4; pfam00037 536019000553 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 536019000554 [4Fe-4S] binding site [ion binding]; other site 536019000555 molybdopterin cofactor binding site; other site 536019000556 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 536019000557 molybdopterin cofactor binding site; other site 536019000558 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 536019000559 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 536019000560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019000561 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 536019000562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019000563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019000564 DNA binding residues [nucleotide binding] 536019000565 dimerization interface [polypeptide binding]; other site 536019000566 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 536019000567 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019000568 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 536019000569 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 536019000570 tetrameric interface [polypeptide binding]; other site 536019000571 NAD binding site [chemical binding]; other site 536019000572 catalytic residues [active] 536019000573 substrate binding site [chemical binding]; other site 536019000574 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000576 dimer interface [polypeptide binding]; other site 536019000577 conserved gate region; other site 536019000578 putative PBP binding loops; other site 536019000579 ABC-ATPase subunit interface; other site 536019000580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000581 putative PBP binding loops; other site 536019000582 dimer interface [polypeptide binding]; other site 536019000583 ABC-ATPase subunit interface; other site 536019000584 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019000585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019000586 Walker A/P-loop; other site 536019000587 ATP binding site [chemical binding]; other site 536019000588 Q-loop/lid; other site 536019000589 ABC transporter signature motif; other site 536019000590 Walker B; other site 536019000591 D-loop; other site 536019000592 H-loop/switch region; other site 536019000593 TOBE domain; Region: TOBE_2; pfam08402 536019000594 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019000595 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019000596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019000597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019000598 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 536019000599 putative substrate binding pocket [chemical binding]; other site 536019000600 dimerization interface [polypeptide binding]; other site 536019000601 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019000602 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536019000603 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019000604 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 536019000605 Phosphotransferase enzyme family; Region: APH; pfam01636 536019000606 active site 536019000607 ATP binding site [chemical binding]; other site 536019000608 substrate binding site [chemical binding]; other site 536019000609 dimer interface [polypeptide binding]; other site 536019000610 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019000611 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019000612 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019000613 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019000614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019000615 S-adenosylmethionine binding site [chemical binding]; other site 536019000616 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 536019000617 active site 536019000618 ATP binding site [chemical binding]; other site 536019000619 Phosphotransferase enzyme family; Region: APH; pfam01636 536019000620 substrate binding site [chemical binding]; other site 536019000621 dimer interface [polypeptide binding]; other site 536019000622 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019000623 EamA-like transporter family; Region: EamA; pfam00892 536019000624 cytosine deaminase; Validated; Region: PRK07572 536019000625 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 536019000626 active site 536019000627 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019000628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019000629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019000630 Walker A/P-loop; other site 536019000631 ATP binding site [chemical binding]; other site 536019000632 Q-loop/lid; other site 536019000633 ABC transporter signature motif; other site 536019000634 Walker B; other site 536019000635 D-loop; other site 536019000636 H-loop/switch region; other site 536019000637 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 536019000638 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 536019000639 dimer interface [polypeptide binding]; other site 536019000640 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 536019000641 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 536019000642 G1 box; other site 536019000643 putative GEF interaction site [polypeptide binding]; other site 536019000644 GTP/Mg2+ binding site [chemical binding]; other site 536019000645 Switch I region; other site 536019000646 G2 box; other site 536019000647 G3 box; other site 536019000648 Switch II region; other site 536019000649 G4 box; other site 536019000650 G5 box; other site 536019000651 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 536019000652 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019000653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019000654 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019000655 Amidase; Region: Amidase; pfam01425 536019000656 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 536019000657 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 536019000658 putative active site [active] 536019000659 putative dimer interface [polypeptide binding]; other site 536019000660 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019000661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019000662 putative DNA binding site [nucleotide binding]; other site 536019000663 putative Zn2+ binding site [ion binding]; other site 536019000664 AsnC family; Region: AsnC_trans_reg; pfam01037 536019000665 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 536019000666 trimer interface [polypeptide binding]; other site 536019000667 active site 536019000668 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019000669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019000670 motif II; other site 536019000671 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 536019000672 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536019000673 tetramer interface [polypeptide binding]; other site 536019000674 active site 536019000675 Mg2+/Mn2+ binding site [ion binding]; other site 536019000676 CysZ-like protein; Reviewed; Region: PRK12768 536019000677 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 536019000678 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 536019000679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019000680 substrate binding site [chemical binding]; other site 536019000681 ATP binding site [chemical binding]; other site 536019000682 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 536019000683 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 536019000684 Malic enzyme, N-terminal domain; Region: malic; pfam00390 536019000685 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 536019000686 putative NAD(P) binding site [chemical binding]; other site 536019000687 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 536019000688 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 536019000689 MutS domain I; Region: MutS_I; pfam01624 536019000690 MutS domain II; Region: MutS_II; pfam05188 536019000691 MutS domain III; Region: MutS_III; pfam05192 536019000692 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 536019000693 Walker A/P-loop; other site 536019000694 ATP binding site [chemical binding]; other site 536019000695 Q-loop/lid; other site 536019000696 ABC transporter signature motif; other site 536019000697 Walker B; other site 536019000698 D-loop; other site 536019000699 H-loop/switch region; other site 536019000700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019000701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019000702 active site 536019000703 catalytic tetrad [active] 536019000704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 536019000705 YHS domain; Region: YHS; pfam04945 536019000706 YHS domain; Region: YHS; pfam04945 536019000707 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 536019000708 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536019000709 Soluble P-type ATPase [General function prediction only]; Region: COG4087 536019000710 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 536019000711 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 536019000712 PII uridylyl-transferase; Provisional; Region: PRK05092 536019000713 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536019000714 metal binding triad; other site 536019000715 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536019000716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019000717 Zn2+ binding site [ion binding]; other site 536019000718 Mg2+ binding site [ion binding]; other site 536019000719 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 536019000720 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 536019000721 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 536019000722 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 536019000723 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 536019000724 putative active site [active] 536019000725 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 536019000726 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 536019000727 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 536019000728 active site 536019000729 HIGH motif; other site 536019000730 dimer interface [polypeptide binding]; other site 536019000731 KMSKS motif; other site 536019000732 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019000733 Ligand Binding Site [chemical binding]; other site 536019000734 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 536019000735 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 536019000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019000737 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019000738 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 536019000739 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 536019000740 DNA binding residues [nucleotide binding] 536019000741 dimer interface [polypeptide binding]; other site 536019000742 copper binding site [ion binding]; other site 536019000743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 536019000744 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 536019000745 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 536019000746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019000747 active site 536019000748 phosphorylation site [posttranslational modification] 536019000749 intermolecular recognition site; other site 536019000750 dimerization interface [polypeptide binding]; other site 536019000751 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 536019000752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019000753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019000754 ATP binding site [chemical binding]; other site 536019000755 Mg2+ binding site [ion binding]; other site 536019000756 G-X-G motif; other site 536019000757 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 536019000758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019000759 ATP binding site [chemical binding]; other site 536019000760 putative Mg++ binding site [ion binding]; other site 536019000761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019000762 nucleotide binding region [chemical binding]; other site 536019000763 ATP-binding site [chemical binding]; other site 536019000764 Helicase associated domain (HA2); Region: HA2; pfam04408 536019000765 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 536019000766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019000767 EamA-like transporter family; Region: EamA; pfam00892 536019000768 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 536019000769 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019000770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019000771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019000772 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000774 dimer interface [polypeptide binding]; other site 536019000775 conserved gate region; other site 536019000776 putative PBP binding loops; other site 536019000777 ABC-ATPase subunit interface; other site 536019000778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019000780 dimer interface [polypeptide binding]; other site 536019000781 conserved gate region; other site 536019000782 putative PBP binding loops; other site 536019000783 ABC-ATPase subunit interface; other site 536019000784 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019000785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019000786 Walker A/P-loop; other site 536019000787 ATP binding site [chemical binding]; other site 536019000788 Q-loop/lid; other site 536019000789 ABC transporter signature motif; other site 536019000790 Walker B; other site 536019000791 D-loop; other site 536019000792 H-loop/switch region; other site 536019000793 TOBE domain; Region: TOBE_2; pfam08402 536019000794 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019000795 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019000796 Walker A/P-loop; other site 536019000797 ATP binding site [chemical binding]; other site 536019000798 Q-loop/lid; other site 536019000799 ABC transporter signature motif; other site 536019000800 Walker B; other site 536019000801 D-loop; other site 536019000802 H-loop/switch region; other site 536019000803 TOBE domain; Region: TOBE_2; pfam08402 536019000804 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 536019000805 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 536019000806 DAK2 domain; Region: Dak2; pfam02734 536019000807 DAK2 domain; Region: Dak2; cl03685 536019000808 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 536019000809 active pocket/dimerization site; other site 536019000810 active site 536019000811 phosphorylation site [posttranslational modification] 536019000812 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536019000813 dimerization domain swap beta strand [polypeptide binding]; other site 536019000814 regulatory protein interface [polypeptide binding]; other site 536019000815 active site 536019000816 regulatory phosphorylation site [posttranslational modification]; other site 536019000817 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 536019000818 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536019000819 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536019000820 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536019000821 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 536019000822 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 536019000823 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 536019000824 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 536019000825 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 536019000826 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 536019000827 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 536019000828 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 536019000829 acyl-activating enzyme (AAE) consensus motif; other site 536019000830 putative AMP binding site [chemical binding]; other site 536019000831 putative active site [active] 536019000832 putative CoA binding site [chemical binding]; other site 536019000833 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019000834 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 536019000835 Chain length determinant protein; Region: Wzz; pfam02706 536019000836 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 536019000837 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 536019000838 active site 536019000839 tetramer interface; other site 536019000840 putative glycosyl transferase; Provisional; Region: PRK10073 536019000841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019000842 active site 536019000843 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 536019000844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019000845 active site 536019000846 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 536019000847 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 536019000848 Ligand binding site; other site 536019000849 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 536019000850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019000851 active site 536019000852 Uncharacterized conserved protein [Function unknown]; Region: COG5663 536019000853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019000854 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019000855 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 536019000856 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019000857 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 536019000858 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019000859 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 536019000860 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 536019000861 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 536019000862 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 536019000863 active site 536019000864 active site 536019000865 catalytic residues [active] 536019000866 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019000867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019000868 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 536019000869 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 536019000870 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 536019000871 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 536019000872 active site 536019000873 dimer interface [polypeptide binding]; other site 536019000874 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 536019000875 Ligand Binding Site [chemical binding]; other site 536019000876 Molecular Tunnel; other site 536019000877 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 536019000878 active site 536019000879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019000880 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 536019000881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019000882 Walker A/P-loop; other site 536019000883 ATP binding site [chemical binding]; other site 536019000884 Q-loop/lid; other site 536019000885 ABC transporter signature motif; other site 536019000886 Walker B; other site 536019000887 D-loop; other site 536019000888 H-loop/switch region; other site 536019000889 Bacterial sugar transferase; Region: Bac_transf; pfam02397 536019000890 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 536019000891 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536019000892 SLBB domain; Region: SLBB; pfam10531 536019000893 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 536019000894 O-Antigen ligase; Region: Wzy_C; pfam04932 536019000895 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019000896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019000897 NAD(P) binding site [chemical binding]; other site 536019000898 active site 536019000899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 536019000900 Putative glucoamylase; Region: Glycoamylase; pfam10091 536019000901 mercuric reductase; Validated; Region: PRK06370 536019000902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019000903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019000904 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019000905 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 536019000906 nucleotide binding site [chemical binding]; other site 536019000907 polymerase nucleotide-binding site; other site 536019000908 primase nucleotide-binding site [nucleotide binding]; other site 536019000909 DNA-binding residues [nucleotide binding]; DNA binding site 536019000910 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019000911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019000912 active site 536019000913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019000914 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 536019000915 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 536019000916 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 536019000917 Anp1; Region: Anp1; pfam03452 536019000918 Uncharacterized conserved protein [Function unknown]; Region: COG3506 536019000919 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 536019000920 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019000921 NAD(P) binding site [chemical binding]; other site 536019000922 catalytic residues [active] 536019000923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019000924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019000925 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 536019000926 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019000927 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 536019000928 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 536019000929 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019000930 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019000931 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019000932 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019000933 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 536019000934 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 536019000935 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 536019000936 Flavin binding site [chemical binding]; other site 536019000937 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019000938 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019000939 Walker A/P-loop; other site 536019000940 ATP binding site [chemical binding]; other site 536019000941 Q-loop/lid; other site 536019000942 ABC transporter signature motif; other site 536019000943 Walker B; other site 536019000944 D-loop; other site 536019000945 H-loop/switch region; other site 536019000946 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 536019000947 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019000948 putative ligand binding site [chemical binding]; other site 536019000949 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019000950 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019000951 TM-ABC transporter signature motif; other site 536019000952 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019000953 TM-ABC transporter signature motif; other site 536019000954 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019000955 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019000956 Walker A/P-loop; other site 536019000957 ATP binding site [chemical binding]; other site 536019000958 Q-loop/lid; other site 536019000959 ABC transporter signature motif; other site 536019000960 Walker B; other site 536019000961 D-loop; other site 536019000962 H-loop/switch region; other site 536019000963 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 536019000964 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 536019000965 active site 536019000966 dimer interface [polypeptide binding]; other site 536019000967 non-prolyl cis peptide bond; other site 536019000968 insertion regions; other site 536019000969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 536019000970 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 536019000971 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 536019000972 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 536019000973 active site 536019000974 dimer interface [polypeptide binding]; other site 536019000975 non-prolyl cis peptide bond; other site 536019000976 insertion regions; other site 536019000977 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 536019000978 inhibitor site; inhibition site 536019000979 active site 536019000980 dimer interface [polypeptide binding]; other site 536019000981 catalytic residue [active] 536019000982 dihydroxy-acid dehydratase; Validated; Region: PRK06131 536019000983 short chain dehydrogenase; Provisional; Region: PRK07063 536019000984 classical (c) SDRs; Region: SDR_c; cd05233 536019000985 NAD(P) binding site [chemical binding]; other site 536019000986 active site 536019000987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019000988 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019000989 TM-ABC transporter signature motif; other site 536019000990 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 536019000991 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019000992 Walker A/P-loop; other site 536019000993 ATP binding site [chemical binding]; other site 536019000994 Q-loop/lid; other site 536019000995 ABC transporter signature motif; other site 536019000996 Walker B; other site 536019000997 D-loop; other site 536019000998 H-loop/switch region; other site 536019000999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019001000 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 536019001001 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 536019001002 ligand binding site [chemical binding]; other site 536019001003 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019001004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019001005 DNA-binding site [nucleotide binding]; DNA binding site 536019001006 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536019001007 galactonate dehydratase; Provisional; Region: PRK14017 536019001008 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 536019001009 putative active site pocket [active] 536019001010 putative metal binding site [ion binding]; other site 536019001011 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019001012 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019001013 ligand binding site [chemical binding]; other site 536019001014 flexible hinge region; other site 536019001015 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 536019001016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 536019001017 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 536019001018 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 536019001019 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 536019001020 hinge; other site 536019001021 active site 536019001022 cytidylate kinase; Provisional; Region: cmk; PRK00023 536019001023 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 536019001024 CMP-binding site; other site 536019001025 The sites determining sugar specificity; other site 536019001026 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 536019001027 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 536019001028 RNA binding site [nucleotide binding]; other site 536019001029 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 536019001030 RNA binding site [nucleotide binding]; other site 536019001031 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 536019001032 RNA binding site [nucleotide binding]; other site 536019001033 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536019001034 RNA binding site [nucleotide binding]; other site 536019001035 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536019001036 RNA binding site [nucleotide binding]; other site 536019001037 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 536019001038 RNA binding site [nucleotide binding]; other site 536019001039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019001040 NAD(P) binding site [chemical binding]; other site 536019001041 active site 536019001042 hypothetical protein; Provisional; Region: PRK07524 536019001043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019001044 PYR/PP interface [polypeptide binding]; other site 536019001045 dimer interface [polypeptide binding]; other site 536019001046 TPP binding site [chemical binding]; other site 536019001047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019001048 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 536019001049 TPP-binding site [chemical binding]; other site 536019001050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019001051 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536019001052 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 536019001053 Amidinotransferase; Region: Amidinotransf; pfam02274 536019001054 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 536019001055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019001056 Walker A/P-loop; other site 536019001057 ATP binding site [chemical binding]; other site 536019001058 Q-loop/lid; other site 536019001059 ABC transporter signature motif; other site 536019001060 Walker B; other site 536019001061 D-loop; other site 536019001062 H-loop/switch region; other site 536019001063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019001064 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019001065 substrate binding pocket [chemical binding]; other site 536019001066 membrane-bound complex binding site; other site 536019001067 hinge residues; other site 536019001068 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001070 dimer interface [polypeptide binding]; other site 536019001071 conserved gate region; other site 536019001072 putative PBP binding loops; other site 536019001073 ABC-ATPase subunit interface; other site 536019001074 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019001075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001076 dimer interface [polypeptide binding]; other site 536019001077 conserved gate region; other site 536019001078 putative PBP binding loops; other site 536019001079 ABC-ATPase subunit interface; other site 536019001080 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 536019001081 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536019001082 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 536019001083 putative NAD(P) binding site [chemical binding]; other site 536019001084 active site 536019001085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019001086 Cytochrome P450; Region: p450; cl12078 536019001087 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019001088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019001089 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019001090 Predicted flavoprotein [General function prediction only]; Region: COG0431 536019001091 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019001092 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019001093 Caspase domain; Region: Peptidase_C14; pfam00656 536019001094 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019001095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019001096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019001097 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 536019001098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019001099 Mg2+ binding site [ion binding]; other site 536019001100 G-X-G motif; other site 536019001101 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 536019001102 anchoring element; other site 536019001103 dimer interface [polypeptide binding]; other site 536019001104 ATP binding site [chemical binding]; other site 536019001105 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 536019001106 active site 536019001107 putative metal-binding site [ion binding]; other site 536019001108 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 536019001109 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 536019001110 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 536019001111 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 536019001112 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 536019001113 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 536019001114 ligand binding site [chemical binding]; other site 536019001115 homodimer interface [polypeptide binding]; other site 536019001116 NAD(P) binding site [chemical binding]; other site 536019001117 trimer interface B [polypeptide binding]; other site 536019001118 trimer interface A [polypeptide binding]; other site 536019001119 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 536019001120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019001121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 536019001122 PAS fold; Region: PAS_7; pfam12860 536019001123 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019001124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019001125 metal binding site [ion binding]; metal-binding site 536019001126 active site 536019001127 I-site; other site 536019001128 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019001129 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 536019001130 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 536019001131 dimer interface [polypeptide binding]; other site 536019001132 PYR/PP interface [polypeptide binding]; other site 536019001133 TPP binding site [chemical binding]; other site 536019001134 substrate binding site [chemical binding]; other site 536019001135 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 536019001136 TPP-binding site; other site 536019001137 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 536019001138 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 536019001139 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 536019001140 CGNR zinc finger; Region: zf-CGNR; pfam11706 536019001141 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019001142 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001143 TM-ABC transporter signature motif; other site 536019001144 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 536019001145 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 536019001146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536019001147 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 536019001148 putative NAD(P) binding site [chemical binding]; other site 536019001149 catalytic Zn binding site [ion binding]; other site 536019001150 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 536019001151 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 536019001152 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 536019001153 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 536019001154 catalytic triad [active] 536019001155 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 536019001156 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 536019001157 putative ligand binding site [chemical binding]; other site 536019001158 NAD binding site [chemical binding]; other site 536019001159 catalytic site [active] 536019001160 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019001161 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019001162 DNA binding site [nucleotide binding] 536019001163 domain linker motif; other site 536019001164 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 536019001165 putative dimerization interface [polypeptide binding]; other site 536019001166 putative ligand binding site [chemical binding]; other site 536019001167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019001168 EamA-like transporter family; Region: EamA; pfam00892 536019001169 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 536019001170 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536019001171 Helix-turn-helix domain; Region: HTH_18; pfam12833 536019001172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019001173 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019001174 MarR family; Region: MarR_2; pfam12802 536019001175 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 536019001176 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 536019001177 P-loop, Walker A motif; other site 536019001178 Base recognition motif; other site 536019001179 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 536019001180 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 536019001181 FOG: WD40 repeat [General function prediction only]; Region: COG2319 536019001182 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 536019001183 structural tetrad; other site 536019001184 aminotransferase; Validated; Region: PRK07046 536019001185 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 536019001186 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019001187 catalytic residue [active] 536019001188 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536019001189 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019001190 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 536019001191 Fe-S cluster binding site [ion binding]; other site 536019001192 active site 536019001193 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 536019001194 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 536019001195 MOFRL family; Region: MOFRL; pfam05161 536019001196 Domain of unknown function (DUF336); Region: DUF336; cl01249 536019001197 guanine deaminase; Provisional; Region: PRK09228 536019001198 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 536019001199 active site 536019001200 Predicted membrane protein [Function unknown]; Region: COG3748 536019001201 Protein of unknown function (DUF989); Region: DUF989; pfam06181 536019001202 Cytochrome c; Region: Cytochrom_C; pfam00034 536019001203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019001204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019001205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019001206 putative effector binding pocket; other site 536019001207 dimerization interface [polypeptide binding]; other site 536019001208 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536019001209 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 536019001210 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 536019001211 active site 536019001212 non-prolyl cis peptide bond; other site 536019001213 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 536019001214 XdhC Rossmann domain; Region: XdhC_C; pfam13478 536019001215 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 536019001216 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019001217 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019001218 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 536019001219 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 536019001220 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019001221 FAD binding domain; Region: FAD_binding_4; pfam01565 536019001222 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536019001223 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 536019001224 active site 536019001225 homotetramer interface [polypeptide binding]; other site 536019001226 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 536019001227 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 536019001228 active site 536019001229 catalytic site [active] 536019001230 tetramer interface [polypeptide binding]; other site 536019001231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 536019001232 hypothetical protein; Provisional; Region: PRK11171 536019001233 Cupin domain; Region: Cupin_2; pfam07883 536019001234 Cupin domain; Region: Cupin_2; cl17218 536019001235 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 536019001236 ureidoglycolate hydrolase; Provisional; Region: PRK03606 536019001237 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 536019001238 nucleoside/Zn binding site; other site 536019001239 dimer interface [polypeptide binding]; other site 536019001240 catalytic motif [active] 536019001241 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 536019001242 Protein of unknown function (DUF497); Region: DUF497; cl01108 536019001243 Predicted acyl esterases [General function prediction only]; Region: COG2936 536019001244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019001245 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 536019001246 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019001247 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019001248 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019001249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001250 dimer interface [polypeptide binding]; other site 536019001251 conserved gate region; other site 536019001252 ABC-ATPase subunit interface; other site 536019001253 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019001254 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536019001255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001256 dimer interface [polypeptide binding]; other site 536019001257 conserved gate region; other site 536019001258 ABC-ATPase subunit interface; other site 536019001259 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 536019001260 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019001261 Walker A/P-loop; other site 536019001262 ATP binding site [chemical binding]; other site 536019001263 Q-loop/lid; other site 536019001264 ABC transporter signature motif; other site 536019001265 Walker B; other site 536019001266 D-loop; other site 536019001267 H-loop/switch region; other site 536019001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019001269 Walker A/P-loop; other site 536019001270 ATP binding site [chemical binding]; other site 536019001271 Q-loop/lid; other site 536019001272 ABC transporter signature motif; other site 536019001273 Walker B; other site 536019001274 D-loop; other site 536019001275 H-loop/switch region; other site 536019001276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019001277 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019001278 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 536019001279 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019001280 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 536019001281 Uncharacterized conserved protein [Function unknown]; Region: COG3379 536019001282 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 536019001283 RNA polymerase sigma factor; Provisional; Region: PRK12515 536019001284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019001285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019001286 DNA binding residues [nucleotide binding] 536019001287 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 536019001288 active site 536019001289 catalytic triad [active] 536019001290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019001291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019001292 DNA binding site [nucleotide binding] 536019001293 domain linker motif; other site 536019001294 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 536019001295 ligand binding site [chemical binding]; other site 536019001296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019001297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019001298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001299 dimer interface [polypeptide binding]; other site 536019001300 conserved gate region; other site 536019001301 putative PBP binding loops; other site 536019001302 ABC-ATPase subunit interface; other site 536019001303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001305 dimer interface [polypeptide binding]; other site 536019001306 conserved gate region; other site 536019001307 putative PBP binding loops; other site 536019001308 ABC-ATPase subunit interface; other site 536019001309 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 536019001310 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 536019001311 active site 536019001312 catalytic site [active] 536019001313 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019001314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019001315 Walker A/P-loop; other site 536019001316 ATP binding site [chemical binding]; other site 536019001317 Q-loop/lid; other site 536019001318 ABC transporter signature motif; other site 536019001319 Walker B; other site 536019001320 D-loop; other site 536019001321 H-loop/switch region; other site 536019001322 TOBE domain; Region: TOBE_2; pfam08402 536019001323 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019001324 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019001325 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019001326 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019001327 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 536019001328 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 536019001329 [2Fe-2S] cluster binding site [ion binding]; other site 536019001330 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 536019001331 putative alpha subunit interface [polypeptide binding]; other site 536019001332 putative active site [active] 536019001333 putative substrate binding site [chemical binding]; other site 536019001334 Fe binding site [ion binding]; other site 536019001335 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 536019001336 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 536019001337 FAD binding pocket [chemical binding]; other site 536019001338 FAD binding motif [chemical binding]; other site 536019001339 phosphate binding motif [ion binding]; other site 536019001340 beta-alpha-beta structure motif; other site 536019001341 NAD binding pocket [chemical binding]; other site 536019001342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019001343 catalytic loop [active] 536019001344 iron binding site [ion binding]; other site 536019001345 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019001346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019001347 active site 536019001348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536019001349 active site 536019001350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019001351 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019001352 active site 536019001353 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 536019001354 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 536019001355 BON domain; Region: BON; cl02771 536019001356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536019001357 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 536019001358 hypothetical protein; Provisional; Region: PRK09256 536019001359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019001360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019001361 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019001362 RibD C-terminal domain; Region: RibD_C; cl17279 536019001363 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 536019001364 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 536019001365 active site 536019001366 substrate-binding site [chemical binding]; other site 536019001367 metal-binding site [ion binding] 536019001368 ATP binding site [chemical binding]; other site 536019001369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019001370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019001371 active site 536019001372 phosphorylation site [posttranslational modification] 536019001373 intermolecular recognition site; other site 536019001374 dimerization interface [polypeptide binding]; other site 536019001375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019001376 DNA binding site [nucleotide binding] 536019001377 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 536019001378 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 536019001379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019001380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019001381 dimer interface [polypeptide binding]; other site 536019001382 phosphorylation site [posttranslational modification] 536019001383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019001384 ATP binding site [chemical binding]; other site 536019001385 Mg2+ binding site [ion binding]; other site 536019001386 G-X-G motif; other site 536019001387 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 536019001388 Hpr binding site; other site 536019001389 active site 536019001390 homohexamer subunit interaction site [polypeptide binding]; other site 536019001391 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 536019001392 active pocket/dimerization site; other site 536019001393 active site 536019001394 phosphorylation site [posttranslational modification] 536019001395 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536019001396 dimerization domain swap beta strand [polypeptide binding]; other site 536019001397 regulatory protein interface [polypeptide binding]; other site 536019001398 active site 536019001399 regulatory phosphorylation site [posttranslational modification]; other site 536019001400 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 536019001401 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 536019001402 homotetramer interface [polypeptide binding]; other site 536019001403 ligand binding site [chemical binding]; other site 536019001404 catalytic site [active] 536019001405 NAD binding site [chemical binding]; other site 536019001406 PAS fold; Region: PAS_7; pfam12860 536019001407 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 536019001408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019001409 dimer interface [polypeptide binding]; other site 536019001410 phosphorylation site [posttranslational modification] 536019001411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019001412 ATP binding site [chemical binding]; other site 536019001413 Mg2+ binding site [ion binding]; other site 536019001414 G-X-G motif; other site 536019001415 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 536019001416 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 536019001417 Phosphotransferase enzyme family; Region: APH; pfam01636 536019001418 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 536019001419 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 536019001420 Substrate binding site; other site 536019001421 metal-binding site 536019001422 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 536019001423 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 536019001424 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 536019001425 Part of AAA domain; Region: AAA_19; pfam13245 536019001426 Family description; Region: UvrD_C_2; pfam13538 536019001427 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 536019001428 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 536019001429 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536019001430 catalytic residues [active] 536019001431 Cupin domain; Region: Cupin_2; cl17218 536019001432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019001433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019001434 active site 536019001435 metal binding site [ion binding]; metal-binding site 536019001436 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 536019001437 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 536019001438 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 536019001439 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 536019001440 substrate binding site [chemical binding]; other site 536019001441 active site 536019001442 catalytic residues [active] 536019001443 heterodimer interface [polypeptide binding]; other site 536019001444 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 536019001445 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 536019001446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019001447 catalytic residue [active] 536019001448 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 536019001449 active site 536019001450 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 536019001451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 536019001452 substrate binding pocket [chemical binding]; other site 536019001453 membrane-bound complex binding site; other site 536019001454 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019001455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001456 dimer interface [polypeptide binding]; other site 536019001457 conserved gate region; other site 536019001458 putative PBP binding loops; other site 536019001459 ABC-ATPase subunit interface; other site 536019001460 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019001461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019001462 Walker A/P-loop; other site 536019001463 ATP binding site [chemical binding]; other site 536019001464 Q-loop/lid; other site 536019001465 ABC transporter signature motif; other site 536019001466 Walker B; other site 536019001467 D-loop; other site 536019001468 H-loop/switch region; other site 536019001469 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 536019001470 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 536019001471 active site 536019001472 non-prolyl cis peptide bond; other site 536019001473 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 536019001474 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 536019001475 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 536019001476 benzoate transporter; Region: benE; TIGR00843 536019001477 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019001478 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 536019001479 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 536019001480 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 536019001481 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019001482 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 536019001483 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 536019001484 23S rRNA binding site [nucleotide binding]; other site 536019001485 L21 binding site [polypeptide binding]; other site 536019001486 L13 binding site [polypeptide binding]; other site 536019001487 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 536019001488 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 536019001489 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 536019001490 dimer interface [polypeptide binding]; other site 536019001491 motif 1; other site 536019001492 active site 536019001493 motif 2; other site 536019001494 motif 3; other site 536019001495 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019001496 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 536019001497 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 536019001498 putative tRNA-binding site [nucleotide binding]; other site 536019001499 B3/4 domain; Region: B3_4; pfam03483 536019001500 tRNA synthetase B5 domain; Region: B5; smart00874 536019001501 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 536019001502 dimer interface [polypeptide binding]; other site 536019001503 motif 1; other site 536019001504 motif 3; other site 536019001505 motif 2; other site 536019001506 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 536019001507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 536019001508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019001509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019001510 active site 536019001511 catalytic tetrad [active] 536019001512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019001513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019001514 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019001515 putative effector binding pocket; other site 536019001516 putative dimerization interface [polypeptide binding]; other site 536019001517 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536019001518 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536019001519 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 536019001520 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 536019001521 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 536019001522 Uncharacterized conserved protein [Function unknown]; Region: COG2353 536019001523 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019001524 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019001525 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019001526 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 536019001527 FAD binding domain; Region: FAD_binding_2; pfam00890 536019001528 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 536019001529 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 536019001530 substrate binding pocket [chemical binding]; other site 536019001531 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 536019001532 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019001533 substrate binding site [chemical binding]; other site 536019001534 oxyanion hole (OAH) forming residues; other site 536019001535 trimer interface [polypeptide binding]; other site 536019001536 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 536019001537 CoA binding domain; Region: CoA_binding_2; pfam13380 536019001538 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 536019001539 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 536019001540 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019001541 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 536019001542 active site 536019001543 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 536019001544 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019001545 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019001546 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 536019001547 Uncharacterized conserved protein [Function unknown]; Region: COG3246 536019001548 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019001549 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 536019001550 conserved cys residue [active] 536019001551 xylose isomerase; Provisional; Region: PRK05474 536019001552 xylose isomerase; Region: xylose_isom_A; TIGR02630 536019001553 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019001554 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 536019001555 N- and C-terminal domain interface [polypeptide binding]; other site 536019001556 D-xylulose kinase; Region: XylB; TIGR01312 536019001557 active site 536019001558 MgATP binding site [chemical binding]; other site 536019001559 catalytic site [active] 536019001560 metal binding site [ion binding]; metal-binding site 536019001561 xylulose binding site [chemical binding]; other site 536019001562 homodimer interface [polypeptide binding]; other site 536019001563 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 536019001564 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 536019001565 Autotransporter beta-domain; Region: Autotransporter; smart00869 536019001566 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019001567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019001568 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019001569 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 536019001570 active site 536019001571 ADP/pyrophosphate binding site [chemical binding]; other site 536019001572 dimerization interface [polypeptide binding]; other site 536019001573 allosteric effector site; other site 536019001574 fructose-1,6-bisphosphate binding site; other site 536019001575 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019001576 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 536019001577 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019001578 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019001579 protein binding site [polypeptide binding]; other site 536019001580 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019001581 protein binding site [polypeptide binding]; other site 536019001582 pantothenate kinase; Provisional; Region: PRK05439 536019001583 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 536019001584 ATP-binding site [chemical binding]; other site 536019001585 CoA-binding site [chemical binding]; other site 536019001586 Mg2+-binding site [ion binding]; other site 536019001587 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 536019001588 metal binding site [ion binding]; metal-binding site 536019001589 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 536019001590 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 536019001591 substrate binding site [chemical binding]; other site 536019001592 glutamase interaction surface [polypeptide binding]; other site 536019001593 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 536019001594 active site 536019001595 Mn binding site [ion binding]; other site 536019001596 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 536019001597 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 536019001598 catalytic residues [active] 536019001599 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 536019001600 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 536019001601 putative active site [active] 536019001602 oxyanion strand; other site 536019001603 catalytic triad [active] 536019001604 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 536019001605 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 536019001606 putative active site pocket [active] 536019001607 4-fold oligomerization interface [polypeptide binding]; other site 536019001608 metal binding residues [ion binding]; metal-binding site 536019001609 3-fold/trimer interface [polypeptide binding]; other site 536019001610 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 536019001611 active site 536019001612 HslU subunit interaction site [polypeptide binding]; other site 536019001613 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 536019001614 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 536019001615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019001616 Coenzyme A binding pocket [chemical binding]; other site 536019001617 hypothetical protein; Provisional; Region: PRK00944 536019001618 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 536019001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019001620 Walker A motif; other site 536019001621 ATP binding site [chemical binding]; other site 536019001622 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 536019001623 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 536019001624 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 536019001625 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 536019001626 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019001627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019001628 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 536019001629 [2Fe-2S] cluster binding site [ion binding]; other site 536019001630 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 536019001631 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 536019001632 putative di-iron ligands [ion binding]; other site 536019001633 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019001634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019001635 DNA binding site [nucleotide binding] 536019001636 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 536019001637 putative ligand binding site [chemical binding]; other site 536019001638 Flagellar protein (FlbD); Region: FlbD; cl00683 536019001639 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 536019001640 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019001641 putative ligand binding site [chemical binding]; other site 536019001642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019001643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001644 TM-ABC transporter signature motif; other site 536019001645 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019001646 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019001647 Walker A/P-loop; other site 536019001648 ATP binding site [chemical binding]; other site 536019001649 Q-loop/lid; other site 536019001650 ABC transporter signature motif; other site 536019001651 Walker B; other site 536019001652 D-loop; other site 536019001653 H-loop/switch region; other site 536019001654 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019001655 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019001656 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019001657 short chain dehydrogenase; Provisional; Region: PRK06198 536019001658 classical (c) SDRs; Region: SDR_c; cd05233 536019001659 NAD(P) binding site [chemical binding]; other site 536019001660 active site 536019001661 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 536019001662 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536019001663 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019001664 Predicted transcriptional regulator [Transcription]; Region: COG2378 536019001665 HTH domain; Region: HTH_11; pfam08279 536019001666 WYL domain; Region: WYL; pfam13280 536019001667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019001668 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019001669 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019001670 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019001671 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019001672 putative active site [active] 536019001673 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019001674 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 536019001675 substrate binding site [chemical binding]; other site 536019001676 ATP binding site [chemical binding]; other site 536019001677 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 536019001678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 536019001679 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 536019001680 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019001681 PYR/PP interface [polypeptide binding]; other site 536019001682 dimer interface [polypeptide binding]; other site 536019001683 TPP binding site [chemical binding]; other site 536019001684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019001685 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 536019001686 TPP-binding site; other site 536019001687 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019001688 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 536019001689 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 536019001690 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019001691 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 536019001692 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 536019001693 active site 536019001694 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 536019001695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019001696 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019001697 substrate binding pocket [chemical binding]; other site 536019001698 membrane-bound complex binding site; other site 536019001699 hinge residues; other site 536019001700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001701 dimer interface [polypeptide binding]; other site 536019001702 conserved gate region; other site 536019001703 putative PBP binding loops; other site 536019001704 ABC-ATPase subunit interface; other site 536019001705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001706 dimer interface [polypeptide binding]; other site 536019001707 conserved gate region; other site 536019001708 putative PBP binding loops; other site 536019001709 ABC-ATPase subunit interface; other site 536019001710 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 536019001711 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001712 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019001713 TM-ABC transporter signature motif; other site 536019001714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019001715 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001716 TM-ABC transporter signature motif; other site 536019001717 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019001718 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019001719 Walker A/P-loop; other site 536019001720 ATP binding site [chemical binding]; other site 536019001721 Q-loop/lid; other site 536019001722 ABC transporter signature motif; other site 536019001723 Walker B; other site 536019001724 D-loop; other site 536019001725 H-loop/switch region; other site 536019001726 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019001727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019001728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019001729 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019001730 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019001731 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 536019001732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019001733 DNA-binding site [nucleotide binding]; DNA binding site 536019001734 UTRA domain; Region: UTRA; pfam07702 536019001735 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 536019001736 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019001737 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 536019001738 ligand binding site [chemical binding]; other site 536019001739 NAD binding site [chemical binding]; other site 536019001740 catalytic site [active] 536019001741 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 536019001742 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 536019001743 tetramer interface [polypeptide binding]; other site 536019001744 TPP-binding site [chemical binding]; other site 536019001745 heterodimer interface [polypeptide binding]; other site 536019001746 phosphorylation loop region [posttranslational modification] 536019001747 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 536019001748 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 536019001749 PYR/PP interface [polypeptide binding]; other site 536019001750 dimer interface [polypeptide binding]; other site 536019001751 TPP binding site [chemical binding]; other site 536019001752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019001753 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019001754 E3 interaction surface; other site 536019001755 lipoyl attachment site [posttranslational modification]; other site 536019001756 galactonate dehydratase; Provisional; Region: PRK14017 536019001757 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019001758 active site pocket [active] 536019001759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019001760 classical (c) SDRs; Region: SDR_c; cd05233 536019001761 NAD(P) binding site [chemical binding]; other site 536019001762 active site 536019001763 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 536019001764 TPP-binding site [chemical binding]; other site 536019001765 dimer interface [polypeptide binding]; other site 536019001766 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 536019001767 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536019001768 PYR/PP interface [polypeptide binding]; other site 536019001769 dimer interface [polypeptide binding]; other site 536019001770 TPP binding site [chemical binding]; other site 536019001771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019001772 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019001773 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019001774 active site pocket [active] 536019001775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019001776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019001777 DNA binding site [nucleotide binding] 536019001778 domain linker motif; other site 536019001779 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 536019001780 putative dimerization interface [polypeptide binding]; other site 536019001781 putative ligand binding site [chemical binding]; other site 536019001782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019001783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001784 TM-ABC transporter signature motif; other site 536019001785 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019001786 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019001787 ligand binding site [chemical binding]; other site 536019001788 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019001789 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019001790 Walker A/P-loop; other site 536019001791 ATP binding site [chemical binding]; other site 536019001792 Q-loop/lid; other site 536019001793 ABC transporter signature motif; other site 536019001794 Walker B; other site 536019001795 D-loop; other site 536019001796 H-loop/switch region; other site 536019001797 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019001798 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019001799 classical (c) SDRs; Region: SDR_c; cd05233 536019001800 NAD(P) binding site [chemical binding]; other site 536019001801 active site 536019001802 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 536019001803 active site 536019001804 catalytic residues [active] 536019001805 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 536019001806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019001807 active site 536019001808 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019001809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019001810 NAD(P) binding site [chemical binding]; other site 536019001811 active site 536019001812 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019001813 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019001814 TM-ABC transporter signature motif; other site 536019001815 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019001816 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019001817 Walker A/P-loop; other site 536019001818 ATP binding site [chemical binding]; other site 536019001819 Q-loop/lid; other site 536019001820 ABC transporter signature motif; other site 536019001821 Walker B; other site 536019001822 D-loop; other site 536019001823 H-loop/switch region; other site 536019001824 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019001825 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 536019001826 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019001827 ligand binding site [chemical binding]; other site 536019001828 dimerization interface [polypeptide binding]; other site 536019001829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019001830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019001831 DNA binding site [nucleotide binding] 536019001832 domain linker motif; other site 536019001833 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 536019001834 putative dimerization interface [polypeptide binding]; other site 536019001835 putative ligand binding site [chemical binding]; other site 536019001836 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 536019001837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019001838 motif II; other site 536019001839 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019001840 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 536019001841 conserved cys residue [active] 536019001842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019001843 hypothetical protein; Provisional; Region: PRK07538 536019001844 hypothetical protein; Provisional; Region: PRK07236 536019001845 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 536019001846 Caspase domain; Region: Peptidase_C14; pfam00656 536019001847 Predicted membrane protein [Function unknown]; Region: COG4420 536019001848 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536019001849 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 536019001850 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 536019001851 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 536019001852 active site 536019001853 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 536019001854 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019001855 C-terminal domain interface [polypeptide binding]; other site 536019001856 GSH binding site (G-site) [chemical binding]; other site 536019001857 dimer interface [polypeptide binding]; other site 536019001858 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 536019001859 dimer interface [polypeptide binding]; other site 536019001860 N-terminal domain interface [polypeptide binding]; other site 536019001861 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 536019001862 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019001863 dimer interface [polypeptide binding]; other site 536019001864 active site 536019001865 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 536019001866 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 536019001867 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 536019001868 alpha-gamma subunit interface [polypeptide binding]; other site 536019001869 beta-gamma subunit interface [polypeptide binding]; other site 536019001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 536019001871 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 536019001872 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 536019001873 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 536019001874 gamma-beta subunit interface [polypeptide binding]; other site 536019001875 alpha-beta subunit interface [polypeptide binding]; other site 536019001876 urease subunit alpha; Reviewed; Region: ureC; PRK13207 536019001877 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 536019001878 subunit interactions [polypeptide binding]; other site 536019001879 active site 536019001880 flap region; other site 536019001881 Domain of unknown function DUF29; Region: DUF29; pfam01724 536019001882 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 536019001883 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019001884 putative C-terminal domain interface [polypeptide binding]; other site 536019001885 putative GSH binding site (G-site) [chemical binding]; other site 536019001886 putative dimer interface [polypeptide binding]; other site 536019001887 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 536019001888 dimer interface [polypeptide binding]; other site 536019001889 N-terminal domain interface [polypeptide binding]; other site 536019001890 putative substrate binding pocket (H-site) [chemical binding]; other site 536019001891 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 536019001892 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 536019001893 dimer interface [polypeptide binding]; other site 536019001894 catalytic residues [active] 536019001895 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 536019001896 UreF; Region: UreF; pfam01730 536019001897 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 536019001898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019001899 hypothetical protein; Provisional; Region: PRK07490 536019001900 active site 536019001901 intersubunit interface [polypeptide binding]; other site 536019001902 Zn2+ binding site [ion binding]; other site 536019001903 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019001904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019001905 motif II; other site 536019001906 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019001907 MarR family; Region: MarR_2; pfam12802 536019001908 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019001909 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019001910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019001911 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019001912 dimerization interface [polypeptide binding]; other site 536019001913 substrate binding pocket [chemical binding]; other site 536019001914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019001915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019001916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001917 putative PBP binding loops; other site 536019001918 dimer interface [polypeptide binding]; other site 536019001919 ABC-ATPase subunit interface; other site 536019001920 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001922 dimer interface [polypeptide binding]; other site 536019001923 conserved gate region; other site 536019001924 putative PBP binding loops; other site 536019001925 ABC-ATPase subunit interface; other site 536019001926 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019001927 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019001928 Walker A/P-loop; other site 536019001929 ATP binding site [chemical binding]; other site 536019001930 Q-loop/lid; other site 536019001931 ABC transporter signature motif; other site 536019001932 Walker B; other site 536019001933 D-loop; other site 536019001934 H-loop/switch region; other site 536019001935 TOBE domain; Region: TOBE_2; pfam08402 536019001936 sorbitol dehydrogenase; Provisional; Region: PRK07067 536019001937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019001938 NAD(P) binding site [chemical binding]; other site 536019001939 active site 536019001940 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 536019001941 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536019001942 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536019001943 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019001944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019001945 motif II; other site 536019001946 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 536019001947 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 536019001948 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 536019001949 N- and C-terminal domain interface [polypeptide binding]; other site 536019001950 active site 536019001951 MgATP binding site [chemical binding]; other site 536019001952 catalytic site [active] 536019001953 metal binding site [ion binding]; metal-binding site 536019001954 carbohydrate binding site [chemical binding]; other site 536019001955 putative homodimer interface [polypeptide binding]; other site 536019001956 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019001957 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019001958 Walker A/P-loop; other site 536019001959 ATP binding site [chemical binding]; other site 536019001960 Q-loop/lid; other site 536019001961 ABC transporter signature motif; other site 536019001962 Walker B; other site 536019001963 D-loop; other site 536019001964 H-loop/switch region; other site 536019001965 TOBE domain; Region: TOBE; pfam03459 536019001966 L-idonate 5-dehydrogenase; Region: PLN02702 536019001967 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 536019001968 inhibitor binding site; inhibition site 536019001969 catalytic Zn binding site [ion binding]; other site 536019001970 structural Zn binding site [ion binding]; other site 536019001971 NADP binding site [chemical binding]; other site 536019001972 tetramer interface [polypeptide binding]; other site 536019001973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019001974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001975 dimer interface [polypeptide binding]; other site 536019001976 conserved gate region; other site 536019001977 putative PBP binding loops; other site 536019001978 ABC-ATPase subunit interface; other site 536019001979 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019001980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001981 dimer interface [polypeptide binding]; other site 536019001982 conserved gate region; other site 536019001983 putative PBP binding loops; other site 536019001984 ABC-ATPase subunit interface; other site 536019001985 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019001986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019001987 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536019001988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019001989 multidrug efflux protein; Reviewed; Region: PRK01766 536019001990 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 536019001991 cation binding site [ion binding]; other site 536019001992 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 536019001993 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536019001994 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019001995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019001996 dimer interface [polypeptide binding]; other site 536019001997 conserved gate region; other site 536019001998 putative PBP binding loops; other site 536019001999 ABC-ATPase subunit interface; other site 536019002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002001 dimer interface [polypeptide binding]; other site 536019002002 conserved gate region; other site 536019002003 putative PBP binding loops; other site 536019002004 ABC-ATPase subunit interface; other site 536019002005 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019002006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019002007 substrate binding pocket [chemical binding]; other site 536019002008 membrane-bound complex binding site; other site 536019002009 hinge residues; other site 536019002010 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 536019002011 agmatinase; Region: agmatinase; TIGR01230 536019002012 oligomer interface [polypeptide binding]; other site 536019002013 putative active site [active] 536019002014 Mn binding site [ion binding]; other site 536019002015 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019002016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019002017 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019002018 dimerization interface [polypeptide binding]; other site 536019002019 substrate binding pocket [chemical binding]; other site 536019002020 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 536019002021 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 536019002022 active site 536019002023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019002024 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 536019002025 ligand binding site [chemical binding]; other site 536019002026 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 536019002027 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019002028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019002029 TM-ABC transporter signature motif; other site 536019002030 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019002031 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019002032 TM-ABC transporter signature motif; other site 536019002033 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019002034 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019002035 Walker A/P-loop; other site 536019002036 ATP binding site [chemical binding]; other site 536019002037 Q-loop/lid; other site 536019002038 ABC transporter signature motif; other site 536019002039 Walker B; other site 536019002040 D-loop; other site 536019002041 H-loop/switch region; other site 536019002042 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019002043 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019002044 Walker A/P-loop; other site 536019002045 ATP binding site [chemical binding]; other site 536019002046 Q-loop/lid; other site 536019002047 ABC transporter signature motif; other site 536019002048 Walker B; other site 536019002049 D-loop; other site 536019002050 H-loop/switch region; other site 536019002051 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 536019002052 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 536019002053 Isochorismatase family; Region: Isochorismatase; pfam00857 536019002054 catalytic triad [active] 536019002055 metal binding site [ion binding]; metal-binding site 536019002056 conserved cis-peptide bond; other site 536019002057 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019002058 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536019002059 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019002060 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019002061 catalytic loop [active] 536019002062 iron binding site [ion binding]; other site 536019002063 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019002064 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019002065 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019002066 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019002067 Uncharacterized conserved protein [Function unknown]; Region: COG2122 536019002068 Amino acid synthesis; Region: AA_synth; pfam06684 536019002069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019002070 MarR family; Region: MarR; pfam01047 536019002071 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 536019002072 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536019002073 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 536019002074 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 536019002075 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536019002076 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536019002077 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536019002078 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 536019002079 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 536019002080 multidrug efflux system protein; Provisional; Region: PRK11431 536019002081 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019002082 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 536019002083 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 536019002084 Cation efflux family; Region: Cation_efflux; pfam01545 536019002085 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019002086 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 536019002087 RmuC family; Region: RmuC; pfam02646 536019002088 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 536019002089 active site 536019002090 catalytic residues [active] 536019002091 metal binding site [ion binding]; metal-binding site 536019002092 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 536019002093 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 536019002094 putative active site [active] 536019002095 substrate binding site [chemical binding]; other site 536019002096 putative cosubstrate binding site; other site 536019002097 catalytic site [active] 536019002098 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 536019002099 substrate binding site [chemical binding]; other site 536019002100 Predicted acetyltransferase [General function prediction only]; Region: COG3153 536019002101 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 536019002102 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 536019002103 dimerization interface 3.5A [polypeptide binding]; other site 536019002104 active site 536019002105 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 536019002106 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 536019002107 metal binding site [ion binding]; metal-binding site 536019002108 dimer interface [polypeptide binding]; other site 536019002109 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 536019002110 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 536019002111 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 536019002112 Predicted membrane protein [Function unknown]; Region: COG3152 536019002113 Predicted membrane protein [Function unknown]; Region: COG3152 536019002114 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 536019002115 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 536019002116 trimer interface [polypeptide binding]; other site 536019002117 active site 536019002118 substrate binding site [chemical binding]; other site 536019002119 CoA binding site [chemical binding]; other site 536019002120 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 536019002121 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 536019002122 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 536019002123 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019002124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019002125 metal binding site [ion binding]; metal-binding site 536019002126 active site 536019002127 I-site; other site 536019002128 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 536019002129 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019002130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019002131 MarR family; Region: MarR; pfam01047 536019002132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019002133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019002134 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 536019002135 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 536019002136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019002137 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 536019002138 cofactor binding site; other site 536019002139 metal binding site [ion binding]; metal-binding site 536019002140 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019002141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019002142 putative DNA binding site [nucleotide binding]; other site 536019002143 putative Zn2+ binding site [ion binding]; other site 536019002144 AsnC family; Region: AsnC_trans_reg; pfam01037 536019002145 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 536019002146 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 536019002147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019002148 FeS/SAM binding site; other site 536019002149 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019002150 homotrimer interaction site [polypeptide binding]; other site 536019002151 putative active site [active] 536019002152 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 536019002153 homohexameric interface [polypeptide binding]; other site 536019002154 feedback inhibition sensing region; other site 536019002155 nucleotide binding site [chemical binding]; other site 536019002156 N-acetyl-L-glutamate binding site [chemical binding]; other site 536019002157 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019002158 Amidase; Region: Amidase; cl11426 536019002159 RNA polymerase sigma factor; Provisional; Region: PRK12514 536019002160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019002161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019002162 DNA binding residues [nucleotide binding] 536019002163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 536019002164 Anti-sigma-K factor rskA; Region: RskA; pfam10099 536019002165 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 536019002166 Fasciclin domain; Region: Fasciclin; pfam02469 536019002167 methionine sulfoxide reductase B; Provisional; Region: PRK00222 536019002168 SelR domain; Region: SelR; pfam01641 536019002169 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019002171 putative substrate translocation pore; other site 536019002172 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536019002173 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019002174 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019002175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019002176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019002177 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 536019002178 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 536019002179 G1 box; other site 536019002180 GTP/Mg2+ binding site [chemical binding]; other site 536019002181 Switch I region; other site 536019002182 G2 box; other site 536019002183 G3 box; other site 536019002184 Switch II region; other site 536019002185 G4 box; other site 536019002186 G5 box; other site 536019002187 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 536019002188 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 536019002189 trimer interface [polypeptide binding]; other site 536019002190 active site 536019002191 substrate binding site [chemical binding]; other site 536019002192 CoA binding site [chemical binding]; other site 536019002193 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019002194 MarR family; Region: MarR_2; pfam12802 536019002195 HlyD family secretion protein; Region: HlyD; pfam00529 536019002196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019002197 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019002198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019002199 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019002200 putative substrate translocation pore; other site 536019002201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019002202 putative substrate translocation pore; other site 536019002203 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 536019002204 Fasciclin domain; Region: Fasciclin; pfam02469 536019002205 membrane protein insertase; Provisional; Region: PRK01318 536019002206 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 536019002207 ribonuclease P; Reviewed; Region: rnpA; PRK01313 536019002208 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 536019002209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019002210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019002211 ATP binding site [chemical binding]; other site 536019002212 Mg2+ binding site [ion binding]; other site 536019002213 G-X-G motif; other site 536019002214 Cupin; Region: Cupin_6; pfam12852 536019002215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019002216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019002217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019002218 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019002219 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019002220 putative NAD(P) binding site [chemical binding]; other site 536019002221 potential frameshift: common BLAST hit: gi|319783433|ref|YP_004142909.1| multicopper oxidase type 3 536019002222 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 536019002223 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 536019002224 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 536019002225 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 536019002226 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 536019002227 Multicopper oxidase; Region: Cu-oxidase; pfam00394 536019002228 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 536019002229 Cytochrome C' Region: Cytochrom_C_2; pfam01322 536019002230 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019002231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019002232 NAD(P) binding site [chemical binding]; other site 536019002233 active site 536019002234 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 536019002235 FCD domain; Region: FCD; pfam07729 536019002236 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019002237 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019002238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019002239 DNA-binding site [nucleotide binding]; DNA binding site 536019002240 FCD domain; Region: FCD; pfam07729 536019002241 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 536019002242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019002243 substrate binding pocket [chemical binding]; other site 536019002244 membrane-bound complex binding site; other site 536019002245 hinge residues; other site 536019002246 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002248 dimer interface [polypeptide binding]; other site 536019002249 conserved gate region; other site 536019002250 putative PBP binding loops; other site 536019002251 ABC-ATPase subunit interface; other site 536019002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002253 dimer interface [polypeptide binding]; other site 536019002254 conserved gate region; other site 536019002255 putative PBP binding loops; other site 536019002256 ABC-ATPase subunit interface; other site 536019002257 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 536019002258 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 536019002259 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 536019002260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 536019002261 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 536019002262 acyl-activating enzyme (AAE) consensus motif; other site 536019002263 acyl-activating enzyme (AAE) consensus motif; other site 536019002264 putative AMP binding site [chemical binding]; other site 536019002265 putative active site [active] 536019002266 putative CoA binding site [chemical binding]; other site 536019002267 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 536019002268 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 536019002269 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 536019002270 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 536019002271 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 536019002272 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019002273 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 536019002274 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 536019002275 metal ion-dependent adhesion site (MIDAS); other site 536019002276 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019002277 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019002278 TM-ABC transporter signature motif; other site 536019002279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019002280 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019002281 TM-ABC transporter signature motif; other site 536019002282 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019002283 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019002284 Walker A/P-loop; other site 536019002285 ATP binding site [chemical binding]; other site 536019002286 Q-loop/lid; other site 536019002287 ABC transporter signature motif; other site 536019002288 Walker B; other site 536019002289 D-loop; other site 536019002290 H-loop/switch region; other site 536019002291 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019002292 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019002293 Walker A/P-loop; other site 536019002294 ATP binding site [chemical binding]; other site 536019002295 Q-loop/lid; other site 536019002296 ABC transporter signature motif; other site 536019002297 Walker B; other site 536019002298 D-loop; other site 536019002299 H-loop/switch region; other site 536019002300 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019002301 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 536019002302 putative ligand binding site [chemical binding]; other site 536019002303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019002304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019002305 DNA binding residues [nucleotide binding] 536019002306 dimerization interface [polypeptide binding]; other site 536019002307 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 536019002308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019002309 Walker A/P-loop; other site 536019002310 ATP binding site [chemical binding]; other site 536019002311 Q-loop/lid; other site 536019002312 ABC transporter signature motif; other site 536019002313 Walker B; other site 536019002314 D-loop; other site 536019002315 H-loop/switch region; other site 536019002316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019002317 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019002318 Walker A/P-loop; other site 536019002319 ATP binding site [chemical binding]; other site 536019002320 Q-loop/lid; other site 536019002321 ABC transporter signature motif; other site 536019002322 Walker B; other site 536019002323 D-loop; other site 536019002324 H-loop/switch region; other site 536019002325 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536019002326 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 536019002327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019002328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 536019002329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002331 dimer interface [polypeptide binding]; other site 536019002332 conserved gate region; other site 536019002333 ABC-ATPase subunit interface; other site 536019002334 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019002335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002336 dimer interface [polypeptide binding]; other site 536019002337 conserved gate region; other site 536019002338 putative PBP binding loops; other site 536019002339 ABC-ATPase subunit interface; other site 536019002340 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 536019002341 ANTAR domain; Region: ANTAR; pfam03861 536019002342 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019002343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019002344 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 536019002345 Cupin domain; Region: Cupin_2; cl17218 536019002346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019002347 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 536019002348 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 536019002349 Flavin Reductases; Region: FlaRed; cl00801 536019002350 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 536019002351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019002352 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 536019002353 putative substrate binding pocket [chemical binding]; other site 536019002354 trimer interface [polypeptide binding]; other site 536019002355 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 536019002356 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 536019002357 NAD binding site [chemical binding]; other site 536019002358 catalytic residues [active] 536019002359 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 536019002360 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 536019002361 tetramer interface [polypeptide binding]; other site 536019002362 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 536019002363 tetramer interface [polypeptide binding]; other site 536019002364 active site 536019002365 metal binding site [ion binding]; metal-binding site 536019002366 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536019002367 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019002368 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 536019002369 Phosphotransferase enzyme family; Region: APH; pfam01636 536019002370 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 536019002371 active site 536019002372 ATP binding site [chemical binding]; other site 536019002373 substrate binding site [chemical binding]; other site 536019002374 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019002376 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019002377 hypothetical protein; Provisional; Region: PRK07481 536019002378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019002379 inhibitor-cofactor binding pocket; inhibition site 536019002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002381 catalytic residue [active] 536019002382 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 536019002383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019002384 motif II; other site 536019002385 hypothetical protein; Provisional; Region: PRK02399 536019002386 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 536019002387 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536019002388 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536019002389 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019002390 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 536019002391 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019002392 Cytochrome P450; Region: p450; cl12078 536019002393 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 536019002394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019002395 NAD(P) binding site [chemical binding]; other site 536019002396 catalytic residues [active] 536019002397 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 536019002398 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 536019002399 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 536019002400 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 536019002401 Walker A/P-loop; other site 536019002402 ATP binding site [chemical binding]; other site 536019002403 Q-loop/lid; other site 536019002404 ABC transporter signature motif; other site 536019002405 Walker B; other site 536019002406 D-loop; other site 536019002407 H-loop/switch region; other site 536019002408 NIL domain; Region: NIL; pfam09383 536019002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002410 dimer interface [polypeptide binding]; other site 536019002411 conserved gate region; other site 536019002412 ABC-ATPase subunit interface; other site 536019002413 Fic/DOC family; Region: Fic; cl00960 536019002414 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019002415 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019002416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019002417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019002418 substrate binding pocket [chemical binding]; other site 536019002419 membrane-bound complex binding site; other site 536019002420 hinge residues; other site 536019002421 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 536019002422 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 536019002423 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 536019002424 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 536019002425 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019002426 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 536019002427 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 536019002428 FAD binding pocket [chemical binding]; other site 536019002429 FAD binding motif [chemical binding]; other site 536019002430 phosphate binding motif [ion binding]; other site 536019002431 beta-alpha-beta structure motif; other site 536019002432 NAD binding pocket [chemical binding]; other site 536019002433 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 536019002434 intersubunit interface [polypeptide binding]; other site 536019002435 active site 536019002436 catalytic residue [active] 536019002437 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 536019002438 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019002439 NAD(P) binding site [chemical binding]; other site 536019002440 catalytic residues [active] 536019002441 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019002442 NAD(P) binding site [chemical binding]; other site 536019002443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019002444 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 536019002445 NAD binding site [chemical binding]; other site 536019002446 homotetramer interface [polypeptide binding]; other site 536019002447 homodimer interface [polypeptide binding]; other site 536019002448 active site 536019002449 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536019002450 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019002451 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019002452 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019002453 Walker A/P-loop; other site 536019002454 ATP binding site [chemical binding]; other site 536019002455 Q-loop/lid; other site 536019002456 ABC transporter signature motif; other site 536019002457 Walker B; other site 536019002458 D-loop; other site 536019002459 H-loop/switch region; other site 536019002460 TOBE domain; Region: TOBE_2; pfam08402 536019002461 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019002462 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019002463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019002464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002465 dimer interface [polypeptide binding]; other site 536019002466 conserved gate region; other site 536019002467 putative PBP binding loops; other site 536019002468 ABC-ATPase subunit interface; other site 536019002469 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536019002470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002471 dimer interface [polypeptide binding]; other site 536019002472 conserved gate region; other site 536019002473 putative PBP binding loops; other site 536019002474 ABC-ATPase subunit interface; other site 536019002475 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019002476 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019002477 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 536019002478 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 536019002479 putative active site [active] 536019002480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536019002481 nucleotide binding site [chemical binding]; other site 536019002482 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 536019002483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019002484 DNA-binding site [nucleotide binding]; DNA binding site 536019002485 UTRA domain; Region: UTRA; pfam07702 536019002486 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 536019002487 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 536019002488 dimer interface [polypeptide binding]; other site 536019002489 active site 536019002490 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536019002491 dimer interface [polypeptide binding]; other site 536019002492 active site 536019002493 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 536019002494 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 536019002495 active site 536019002496 dimer interface [polypeptide binding]; other site 536019002497 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019002498 Predicted dehydrogenase [General function prediction only]; Region: COG0579 536019002499 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 536019002500 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 536019002501 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 536019002502 malonyl-CoA synthase; Validated; Region: PRK07514 536019002503 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 536019002504 acyl-activating enzyme (AAE) consensus motif; other site 536019002505 active site 536019002506 AMP binding site [chemical binding]; other site 536019002507 CoA binding site [chemical binding]; other site 536019002508 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019002509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019002510 DNA-binding site [nucleotide binding]; DNA binding site 536019002511 FCD domain; Region: FCD; pfam07729 536019002512 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 536019002513 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536019002514 substrate binding site [chemical binding]; other site 536019002515 hexamer interface [polypeptide binding]; other site 536019002516 metal binding site [ion binding]; metal-binding site 536019002517 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019002518 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 536019002519 peptide binding site [polypeptide binding]; other site 536019002520 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 536019002521 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 536019002522 nucleotide binding site [chemical binding]; other site 536019002523 NEF interaction site [polypeptide binding]; other site 536019002524 SBD interface [polypeptide binding]; other site 536019002525 chaperone protein DnaJ; Provisional; Region: PRK10767 536019002526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019002527 HSP70 interaction site [polypeptide binding]; other site 536019002528 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 536019002529 substrate binding site [polypeptide binding]; other site 536019002530 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 536019002531 Zn binding sites [ion binding]; other site 536019002532 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 536019002533 dimer interface [polypeptide binding]; other site 536019002534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019002535 S-adenosylmethionine binding site [chemical binding]; other site 536019002536 Predicted flavoprotein [General function prediction only]; Region: COG0431 536019002537 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019002538 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 536019002539 active site 536019002540 dimer interface [polypeptide binding]; other site 536019002541 Uncharacterized conserved protein [Function unknown]; Region: COG5470 536019002542 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019002543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019002544 DNA-binding site [nucleotide binding]; DNA binding site 536019002545 FCD domain; Region: FCD; pfam07729 536019002546 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 536019002547 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019002548 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 536019002549 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 536019002550 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 536019002551 active site 536019002552 intersubunit interface [polypeptide binding]; other site 536019002553 catalytic residue [active] 536019002554 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 536019002555 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 536019002556 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 536019002557 classical (c) SDRs; Region: SDR_c; cd05233 536019002558 NAD(P) binding site [chemical binding]; other site 536019002559 active site 536019002560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019002561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019002562 metal binding site [ion binding]; metal-binding site 536019002563 active site 536019002564 I-site; other site 536019002565 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019002566 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019002567 Methyltransferase domain; Region: Methyltransf_11; pfam08241 536019002568 Predicted membrane protein [Function unknown]; Region: COG2246 536019002569 GtrA-like protein; Region: GtrA; pfam04138 536019002570 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 536019002571 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 536019002572 Ligand binding site; other site 536019002573 Putative Catalytic site; other site 536019002574 DXD motif; other site 536019002575 glutathione synthetase; Provisional; Region: PRK05246 536019002576 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 536019002577 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 536019002578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019002579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019002580 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 536019002581 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 536019002582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019002583 Walker A motif; other site 536019002584 ATP binding site [chemical binding]; other site 536019002585 Walker B motif; other site 536019002586 arginine finger; other site 536019002587 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 536019002588 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 536019002589 active site 536019002590 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 536019002591 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 536019002592 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019002593 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019002594 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 536019002595 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 536019002596 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 536019002597 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 536019002598 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 536019002599 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019002600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019002601 DNA binding site [nucleotide binding] 536019002602 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019002603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019002604 TPR motif; other site 536019002605 binding surface 536019002606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019002607 TPR motif; other site 536019002608 binding surface 536019002609 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 536019002610 tyrosine decarboxylase; Region: PLN02880 536019002611 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 536019002612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002613 catalytic residue [active] 536019002614 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019002615 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019002616 dimer interface [polypeptide binding]; other site 536019002617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002618 catalytic residue [active] 536019002619 Bacterial transcriptional activator domain; Region: BTAD; smart01043 536019002620 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019002621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019002622 TPR motif; other site 536019002623 binding surface 536019002624 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 536019002625 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019002626 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019002627 ligand binding site [chemical binding]; other site 536019002628 flexible hinge region; other site 536019002629 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 536019002630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019002631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 536019002633 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 536019002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019002635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019002636 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 536019002637 ArsC family; Region: ArsC; pfam03960 536019002638 catalytic residues [active] 536019002639 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 536019002640 amphipathic channel; other site 536019002641 Asn-Pro-Ala signature motifs; other site 536019002642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019002643 putative DNA binding site [nucleotide binding]; other site 536019002644 putative Zn2+ binding site [ion binding]; other site 536019002645 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 536019002646 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 536019002647 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019002648 catalytic core [active] 536019002649 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 536019002650 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 536019002651 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 536019002652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019002653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019002654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019002655 Walker A/P-loop; other site 536019002656 ATP binding site [chemical binding]; other site 536019002657 Q-loop/lid; other site 536019002658 ABC transporter signature motif; other site 536019002659 Walker B; other site 536019002660 D-loop; other site 536019002661 H-loop/switch region; other site 536019002662 glucokinase; Provisional; Region: glk; PRK00292 536019002663 glucokinase, proteobacterial type; Region: glk; TIGR00749 536019002664 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 536019002665 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 536019002666 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019002667 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 536019002668 putative NAD(P) binding site [chemical binding]; other site 536019002669 epoxyqueuosine reductase; Region: TIGR00276 536019002670 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 536019002671 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019002672 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536019002673 C-terminal domain interface [polypeptide binding]; other site 536019002674 GSH binding site (G-site) [chemical binding]; other site 536019002675 dimer interface [polypeptide binding]; other site 536019002676 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 536019002677 N-terminal domain interface [polypeptide binding]; other site 536019002678 dimer interface [polypeptide binding]; other site 536019002679 substrate binding pocket (H-site) [chemical binding]; other site 536019002680 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 536019002681 hypothetical protein; Reviewed; Region: PRK12497 536019002682 Predicted methyltransferases [General function prediction only]; Region: COG0313 536019002683 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 536019002684 putative SAM binding site [chemical binding]; other site 536019002685 putative homodimer interface [polypeptide binding]; other site 536019002686 Predicted membrane protein [Function unknown]; Region: COG2510 536019002687 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 536019002688 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 536019002689 active site 536019002690 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 536019002691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019002692 FeS/SAM binding site; other site 536019002693 HemN C-terminal domain; Region: HemN_C; pfam06969 536019002694 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 536019002695 active site 536019002696 dimerization interface [polypeptide binding]; other site 536019002697 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 536019002698 putative metal binding site [ion binding]; other site 536019002699 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019002700 ribonuclease PH; Reviewed; Region: rph; PRK00173 536019002701 Ribonuclease PH; Region: RNase_PH_bact; cd11362 536019002702 hexamer interface [polypeptide binding]; other site 536019002703 active site 536019002704 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 536019002705 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 536019002706 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 536019002707 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019002708 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019002709 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019002710 dimer interface [polypeptide binding]; other site 536019002711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002712 catalytic residue [active] 536019002713 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019002714 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 536019002715 C-terminal domain interface [polypeptide binding]; other site 536019002716 GSH binding site (G-site) [chemical binding]; other site 536019002717 dimer interface [polypeptide binding]; other site 536019002718 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 536019002719 dimer interface [polypeptide binding]; other site 536019002720 N-terminal domain interface [polypeptide binding]; other site 536019002721 substrate binding pocket (H-site) [chemical binding]; other site 536019002722 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 536019002723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 536019002724 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 536019002725 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 536019002726 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 536019002727 DctM-like transporters; Region: DctM; pfam06808 536019002728 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 536019002729 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 536019002730 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 536019002731 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 536019002732 putative DNA binding site [nucleotide binding]; other site 536019002733 putative homodimer interface [polypeptide binding]; other site 536019002734 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 536019002735 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 536019002736 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 536019002737 active site 536019002738 DNA binding site [nucleotide binding] 536019002739 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 536019002740 DNA binding site [nucleotide binding] 536019002741 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 536019002742 nucleotide binding site [chemical binding]; other site 536019002743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019002744 dimerization interface [polypeptide binding]; other site 536019002745 putative DNA binding site [nucleotide binding]; other site 536019002746 putative Zn2+ binding site [ion binding]; other site 536019002747 NIPSNAP; Region: NIPSNAP; pfam07978 536019002748 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 536019002749 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 536019002750 diiron binding motif [ion binding]; other site 536019002751 Uncharacterized conserved protein [Function unknown]; Region: COG1633 536019002752 CCC1-related protein family; Region: CCC1_like_1; cd02437 536019002753 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536019002754 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536019002755 tetramer interface [polypeptide binding]; other site 536019002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002757 catalytic residue [active] 536019002758 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 536019002759 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 536019002760 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536019002761 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 536019002762 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 536019002763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536019002764 Walker A/P-loop; other site 536019002765 ATP binding site [chemical binding]; other site 536019002766 Q-loop/lid; other site 536019002767 ABC transporter signature motif; other site 536019002768 Walker B; other site 536019002769 D-loop; other site 536019002770 H-loop/switch region; other site 536019002771 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 536019002772 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019002773 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 536019002774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019002775 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 536019002776 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 536019002777 putative active site [active] 536019002778 putative metal binding residues [ion binding]; other site 536019002779 signature motif; other site 536019002780 putative dimer interface [polypeptide binding]; other site 536019002781 putative phosphate binding site [ion binding]; other site 536019002782 CHAD domain; Region: CHAD; pfam05235 536019002783 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 536019002784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019002785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019002786 non-specific DNA binding site [nucleotide binding]; other site 536019002787 salt bridge; other site 536019002788 sequence-specific DNA binding site [nucleotide binding]; other site 536019002789 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 536019002790 active site 536019002791 DNA binding site [nucleotide binding] 536019002792 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 536019002793 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536019002794 active site 536019002795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 536019002796 Histidine kinase; Region: HisKA_3; pfam07730 536019002797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019002798 ATP binding site [chemical binding]; other site 536019002799 Mg2+ binding site [ion binding]; other site 536019002800 G-X-G motif; other site 536019002801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019002802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019002803 active site 536019002804 phosphorylation site [posttranslational modification] 536019002805 intermolecular recognition site; other site 536019002806 dimerization interface [polypeptide binding]; other site 536019002807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019002808 DNA binding residues [nucleotide binding] 536019002809 dimerization interface [polypeptide binding]; other site 536019002810 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 536019002811 Predicted acetyltransferase [General function prediction only]; Region: COG3393 536019002812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019002813 Coenzyme A binding pocket [chemical binding]; other site 536019002814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019002815 putative DNA binding site [nucleotide binding]; other site 536019002816 putative Zn2+ binding site [ion binding]; other site 536019002817 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 536019002818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019002819 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 536019002820 NAD(P) binding pocket [chemical binding]; other site 536019002821 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 536019002822 ABC-2 type transporter; Region: ABC2_membrane; cl17235 536019002823 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 536019002824 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 536019002825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536019002826 Walker A/P-loop; other site 536019002827 ATP binding site [chemical binding]; other site 536019002828 Q-loop/lid; other site 536019002829 ABC transporter signature motif; other site 536019002830 Walker B; other site 536019002831 D-loop; other site 536019002832 H-loop/switch region; other site 536019002833 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 536019002834 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 536019002835 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 536019002836 Predicted ATPase [General function prediction only]; Region: COG3899 536019002837 AAA ATPase domain; Region: AAA_16; pfam13191 536019002838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019002839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019002840 DNA binding residues [nucleotide binding] 536019002841 dimerization interface [polypeptide binding]; other site 536019002842 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 536019002843 methionine sulfoxide reductase A; Provisional; Region: PRK13014 536019002844 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 536019002845 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019002846 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 536019002847 GTP-binding protein LepA; Provisional; Region: PRK05433 536019002848 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 536019002849 G1 box; other site 536019002850 putative GEF interaction site [polypeptide binding]; other site 536019002851 GTP/Mg2+ binding site [chemical binding]; other site 536019002852 Switch I region; other site 536019002853 G2 box; other site 536019002854 G3 box; other site 536019002855 Switch II region; other site 536019002856 G4 box; other site 536019002857 G5 box; other site 536019002858 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 536019002859 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 536019002860 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 536019002861 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 536019002862 active site 536019002863 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019002864 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019002865 preprotein translocase subunit SecB; Validated; Region: PRK05751 536019002866 SecA binding site; other site 536019002867 Preprotein binding site; other site 536019002868 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 536019002869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 536019002870 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 536019002871 MltA specific insert domain; Region: MltA; smart00925 536019002872 3D domain; Region: 3D; pfam06725 536019002873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 536019002874 Smr domain; Region: Smr; pfam01713 536019002875 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019002876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019002877 non-specific DNA binding site [nucleotide binding]; other site 536019002878 salt bridge; other site 536019002879 sequence-specific DNA binding site [nucleotide binding]; other site 536019002880 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 536019002881 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 536019002882 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 536019002883 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 536019002884 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 536019002885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019002886 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019002887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019002888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019002890 dimer interface [polypeptide binding]; other site 536019002891 conserved gate region; other site 536019002892 putative PBP binding loops; other site 536019002893 ABC-ATPase subunit interface; other site 536019002894 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 536019002895 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019002896 Walker A/P-loop; other site 536019002897 ATP binding site [chemical binding]; other site 536019002898 Q-loop/lid; other site 536019002899 ABC transporter signature motif; other site 536019002900 Walker B; other site 536019002901 D-loop; other site 536019002902 H-loop/switch region; other site 536019002903 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 536019002904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019002905 substrate binding pocket [chemical binding]; other site 536019002906 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 536019002907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019002908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019002909 DNA binding residues [nucleotide binding] 536019002910 dimerization interface [polypeptide binding]; other site 536019002911 YadA-like C-terminal region; Region: YadA; pfam03895 536019002912 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019002913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019002914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019002915 DNA binding residues [nucleotide binding] 536019002916 Predicted transcriptional regulator [Transcription]; Region: COG1959 536019002917 Transcriptional regulator; Region: Rrf2; pfam02082 536019002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 536019002919 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 536019002920 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019002921 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019002922 dimer interface [polypeptide binding]; other site 536019002923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002924 catalytic residue [active] 536019002925 FOG: CBS domain [General function prediction only]; Region: COG0517 536019002926 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 536019002927 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 536019002928 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536019002929 homodimer interface [polypeptide binding]; other site 536019002930 substrate-cofactor binding pocket; other site 536019002931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019002932 catalytic residue [active] 536019002933 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019002934 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 536019002935 conserved cys residue [active] 536019002936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019002937 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019002938 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019002939 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019002940 active site 536019002941 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 536019002942 Isochorismatase family; Region: Isochorismatase; pfam00857 536019002943 catalytic triad [active] 536019002944 conserved cis-peptide bond; other site 536019002945 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019002946 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 536019002947 active site 536019002948 catalytic site [active] 536019002949 substrate binding site [chemical binding]; other site 536019002950 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 536019002951 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 536019002952 CoA-binding site [chemical binding]; other site 536019002953 ATP-binding [chemical binding]; other site 536019002954 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 536019002955 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 536019002956 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 536019002957 shikimate binding site; other site 536019002958 NAD(P) binding site [chemical binding]; other site 536019002959 Maf-like protein; Region: Maf; pfam02545 536019002960 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 536019002961 active site 536019002962 dimer interface [polypeptide binding]; other site 536019002963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 536019002964 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 536019002965 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 536019002966 substrate binding site [chemical binding]; other site 536019002967 active site 536019002968 Predicted membrane protein [Function unknown]; Region: COG1981 536019002969 transcription termination factor Rho; Provisional; Region: rho; PRK09376 536019002970 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 536019002971 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 536019002972 RNA binding site [nucleotide binding]; other site 536019002973 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 536019002974 multimer interface [polypeptide binding]; other site 536019002975 Walker A motif; other site 536019002976 ATP binding site [chemical binding]; other site 536019002977 Walker B motif; other site 536019002978 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019002979 EamA-like transporter family; Region: EamA; pfam00892 536019002980 EamA-like transporter family; Region: EamA; pfam00892 536019002981 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 536019002982 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 536019002983 catalytic residues [active] 536019002984 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 536019002985 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 536019002986 trmE is a tRNA modification GTPase; Region: trmE; cd04164 536019002987 G1 box; other site 536019002988 GTP/Mg2+ binding site [chemical binding]; other site 536019002989 Switch I region; other site 536019002990 G2 box; other site 536019002991 Switch II region; other site 536019002992 G3 box; other site 536019002993 G4 box; other site 536019002994 G5 box; other site 536019002995 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 536019002996 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 536019002997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019002998 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 536019002999 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 536019003000 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 536019003001 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 536019003002 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 536019003003 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019003004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 536019003005 Magnesium ion binding site [ion binding]; other site 536019003006 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 536019003007 ParB-like nuclease domain; Region: ParBc; pfam02195 536019003008 KorB domain; Region: KorB; pfam08535 536019003009 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 536019003010 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 536019003011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019003012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019003013 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019003014 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 536019003015 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 536019003016 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 536019003017 tetramer interface [polypeptide binding]; other site 536019003018 TPP-binding site [chemical binding]; other site 536019003019 heterodimer interface [polypeptide binding]; other site 536019003020 phosphorylation loop region [posttranslational modification] 536019003021 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 536019003022 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 536019003023 alpha subunit interface [polypeptide binding]; other site 536019003024 TPP binding site [chemical binding]; other site 536019003025 heterodimer interface [polypeptide binding]; other site 536019003026 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019003027 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 536019003028 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019003029 E3 interaction surface; other site 536019003030 lipoyl attachment site [posttranslational modification]; other site 536019003031 e3 binding domain; Region: E3_binding; pfam02817 536019003032 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536019003033 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 536019003034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019003035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019003036 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019003037 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 536019003038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003039 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019003040 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 536019003041 AsnC family; Region: AsnC_trans_reg; pfam01037 536019003042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019003043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019003044 dimer interface [polypeptide binding]; other site 536019003045 phosphorylation site [posttranslational modification] 536019003046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019003047 ATP binding site [chemical binding]; other site 536019003048 Mg2+ binding site [ion binding]; other site 536019003049 G-X-G motif; other site 536019003050 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 536019003051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019003052 active site 536019003053 phosphorylation site [posttranslational modification] 536019003054 intermolecular recognition site; other site 536019003055 dimerization interface [polypeptide binding]; other site 536019003056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019003057 DNA binding site [nucleotide binding] 536019003058 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 536019003059 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 536019003060 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 536019003061 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 536019003062 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 536019003063 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019003064 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019003065 homotrimer interaction site [polypeptide binding]; other site 536019003066 putative active site [active] 536019003067 Predicted amidohydrolase [General function prediction only]; Region: COG3964 536019003068 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 536019003069 active site 536019003070 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 536019003071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 536019003072 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 536019003073 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019003074 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019003075 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019003076 putative active site [active] 536019003077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019003078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019003079 Walker A/P-loop; other site 536019003080 ATP binding site [chemical binding]; other site 536019003081 Q-loop/lid; other site 536019003082 ABC transporter signature motif; other site 536019003083 Walker B; other site 536019003084 D-loop; other site 536019003085 H-loop/switch region; other site 536019003086 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003088 dimer interface [polypeptide binding]; other site 536019003089 conserved gate region; other site 536019003090 putative PBP binding loops; other site 536019003091 ABC-ATPase subunit interface; other site 536019003092 NMT1/THI5 like; Region: NMT1; pfam09084 536019003093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019003094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019003095 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019003096 Amidase; Region: Amidase; pfam01425 536019003097 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019003098 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019003099 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019003100 active site 536019003101 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 536019003102 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 536019003103 putative deacylase active site [active] 536019003104 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 536019003105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 536019003106 catalytic residues [active] 536019003107 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 536019003108 Uncharacterized conserved protein [Function unknown]; Region: COG2835 536019003109 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 536019003110 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 536019003111 putative active site [active] 536019003112 putative PHP Thumb interface [polypeptide binding]; other site 536019003113 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 536019003114 generic binding surface I; other site 536019003115 generic binding surface II; other site 536019003116 DNA Polymerase Y-family; Region: PolY_like; cd03468 536019003117 active site 536019003118 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 536019003119 DNA binding site [nucleotide binding] 536019003120 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 536019003121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019003122 sequence-specific DNA binding site [nucleotide binding]; other site 536019003123 salt bridge; other site 536019003124 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 536019003125 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 536019003126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019003127 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019003128 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019003129 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 536019003130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019003132 active site 536019003133 phosphorylation site [posttranslational modification] 536019003134 intermolecular recognition site; other site 536019003135 dimerization interface [polypeptide binding]; other site 536019003136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019003137 DNA binding site [nucleotide binding] 536019003138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019003139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536019003140 dimerization interface [polypeptide binding]; other site 536019003141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019003142 dimer interface [polypeptide binding]; other site 536019003143 phosphorylation site [posttranslational modification] 536019003144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019003145 ATP binding site [chemical binding]; other site 536019003146 Mg2+ binding site [ion binding]; other site 536019003147 G-X-G motif; other site 536019003148 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019003149 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 536019003150 putative hydrophobic ligand binding site [chemical binding]; other site 536019003151 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 536019003152 putative hydrophobic ligand binding site [chemical binding]; other site 536019003153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019003154 dimerization interface [polypeptide binding]; other site 536019003155 putative DNA binding site [nucleotide binding]; other site 536019003156 putative Zn2+ binding site [ion binding]; other site 536019003157 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019003158 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 536019003159 Coenzyme A binding pocket [chemical binding]; other site 536019003160 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 536019003161 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 536019003162 substrate binding site [chemical binding]; other site 536019003163 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 536019003164 homotrimer interaction site [polypeptide binding]; other site 536019003165 putative active site [active] 536019003166 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 536019003167 dimer interface [polypeptide binding]; other site 536019003168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019003169 tartrate dehydrogenase; Region: TTC; TIGR02089 536019003170 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 536019003171 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019003172 MarR family; Region: MarR; pfam01047 536019003173 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 536019003174 hydrophobic ligand binding site; other site 536019003175 Predicted membrane protein [Function unknown]; Region: COG3152 536019003176 Predicted membrane protein [Function unknown]; Region: COG3152 536019003177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019003178 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019003179 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 536019003180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019003181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019003182 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 536019003183 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 536019003184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 536019003185 ATP binding site [chemical binding]; other site 536019003186 putative Mg++ binding site [ion binding]; other site 536019003187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019003188 nucleotide binding region [chemical binding]; other site 536019003189 ATP-binding site [chemical binding]; other site 536019003190 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 536019003191 RNA binding site [nucleotide binding]; other site 536019003192 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 536019003193 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536019003194 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 536019003195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 536019003196 ACT domain; Region: ACT_3; pfam10000 536019003197 Family description; Region: ACT_7; pfam13840 536019003198 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 536019003199 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 536019003200 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 536019003201 chorismate mutase; Provisional; Region: PRK09239 536019003202 signal recognition particle protein; Provisional; Region: PRK10867 536019003203 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 536019003204 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 536019003205 P loop; other site 536019003206 GTP binding site [chemical binding]; other site 536019003207 Signal peptide binding domain; Region: SRP_SPB; pfam02978 536019003208 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 536019003209 Bacterial SH3 domain; Region: SH3_3; pfam08239 536019003210 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 536019003211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 536019003212 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 536019003213 Transglycosylase SLT domain; Region: SLT_2; pfam13406 536019003214 murein hydrolase B; Provisional; Region: PRK10760; cl17906 536019003215 argininosuccinate synthase; Provisional; Region: PRK13820 536019003216 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 536019003217 ANP binding site [chemical binding]; other site 536019003218 Substrate Binding Site II [chemical binding]; other site 536019003219 Substrate Binding Site I [chemical binding]; other site 536019003220 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019003221 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 536019003222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019003223 FeS/SAM binding site; other site 536019003224 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536019003225 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 536019003226 putative ion selectivity filter; other site 536019003227 putative pore gating glutamate residue; other site 536019003228 putative H+/Cl- coupling transport residue; other site 536019003229 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 536019003230 Uncharacterized conserved protein [Function unknown]; Region: COG3339 536019003231 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 536019003232 aromatic arch; other site 536019003233 DCoH dimer interaction site [polypeptide binding]; other site 536019003234 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 536019003235 DCoH tetramer interaction site [polypeptide binding]; other site 536019003236 substrate binding site [chemical binding]; other site 536019003237 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 536019003238 Low molecular weight phosphatase family; Region: LMWPc; cd00115 536019003239 active site 536019003240 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 536019003241 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 536019003242 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 536019003243 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 536019003244 active site 536019003245 catalytic triad [active] 536019003246 oxyanion hole [active] 536019003247 switch loop; other site 536019003248 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 536019003249 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536019003250 Walker A/P-loop; other site 536019003251 ATP binding site [chemical binding]; other site 536019003252 Q-loop/lid; other site 536019003253 ABC transporter signature motif; other site 536019003254 Walker B; other site 536019003255 D-loop; other site 536019003256 H-loop/switch region; other site 536019003257 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 536019003258 FtsX-like permease family; Region: FtsX; pfam02687 536019003259 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 536019003260 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 536019003261 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 536019003262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019003263 Coenzyme A binding pocket [chemical binding]; other site 536019003264 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 536019003265 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019003266 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019003267 Uncharacterized secreted protein [Function unknown]; Region: COG5429 536019003268 Ceramidase; Region: Ceramidase; pfam05875 536019003269 aconitate hydratase; Validated; Region: PRK09277 536019003270 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 536019003271 substrate binding site [chemical binding]; other site 536019003272 ligand binding site [chemical binding]; other site 536019003273 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 536019003274 substrate binding site [chemical binding]; other site 536019003275 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 536019003276 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 536019003277 Walker A/P-loop; other site 536019003278 ATP binding site [chemical binding]; other site 536019003279 Q-loop/lid; other site 536019003280 ABC transporter signature motif; other site 536019003281 Walker B; other site 536019003282 D-loop; other site 536019003283 H-loop/switch region; other site 536019003284 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 536019003285 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 536019003286 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 536019003287 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536019003288 catalytic residues [active] 536019003289 central insert; other site 536019003290 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 536019003291 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 536019003292 active site 1 [active] 536019003293 dimer interface [polypeptide binding]; other site 536019003294 hexamer interface [polypeptide binding]; other site 536019003295 active site 2 [active] 536019003296 Predicted flavoprotein [General function prediction only]; Region: COG0431 536019003297 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019003298 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 536019003299 intracellular septation protein A; Reviewed; Region: PRK00259 536019003300 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 536019003301 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 536019003302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019003303 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 536019003304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 536019003305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019003306 FeS/SAM binding site; other site 536019003307 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 536019003308 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 536019003309 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 536019003310 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 536019003311 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 536019003312 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 536019003313 active site 536019003314 Protease inhibitor Inh; Region: Inh; pfam02974 536019003315 Predicted ATPase [General function prediction only]; Region: COG1485 536019003316 malate dehydrogenase; Reviewed; Region: PRK06223 536019003317 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 536019003318 NAD(P) binding site [chemical binding]; other site 536019003319 dimer interface [polypeptide binding]; other site 536019003320 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019003321 substrate binding site [chemical binding]; other site 536019003322 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 536019003323 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 536019003324 CoA-ligase; Region: Ligase_CoA; pfam00549 536019003325 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 536019003326 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 536019003327 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 536019003328 CoA binding domain; Region: CoA_binding; smart00881 536019003329 CoA-ligase; Region: Ligase_CoA; pfam00549 536019003330 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 536019003331 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 536019003332 TPP-binding site [chemical binding]; other site 536019003333 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 536019003334 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 536019003335 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019003336 E3 interaction surface; other site 536019003337 lipoyl attachment site [posttranslational modification]; other site 536019003338 e3 binding domain; Region: E3_binding; pfam02817 536019003339 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536019003340 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 536019003341 short chain dehydrogenase; Provisional; Region: PRK06123 536019003342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003343 NAD(P) binding site [chemical binding]; other site 536019003344 active site 536019003345 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 536019003346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019003347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019003348 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019003349 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 536019003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 536019003351 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 536019003352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536019003353 active site 536019003354 DNA binding site [nucleotide binding] 536019003355 Int/Topo IB signature motif; other site 536019003356 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 536019003357 RimM N-terminal domain; Region: RimM; pfam01782 536019003358 PRC-barrel domain; Region: PRC; pfam05239 536019003359 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 536019003360 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 536019003361 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 536019003362 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 536019003363 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019003364 MarR family; Region: MarR; pfam01047 536019003365 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019003366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019003367 substrate binding pocket [chemical binding]; other site 536019003368 membrane-bound complex binding site; other site 536019003369 hinge residues; other site 536019003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003371 dimer interface [polypeptide binding]; other site 536019003372 conserved gate region; other site 536019003373 putative PBP binding loops; other site 536019003374 ABC-ATPase subunit interface; other site 536019003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019003376 S-adenosylmethionine binding site [chemical binding]; other site 536019003377 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 536019003378 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 536019003379 substrate binding site [chemical binding]; other site 536019003380 ligand binding site [chemical binding]; other site 536019003381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019003382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019003383 metal binding site [ion binding]; metal-binding site 536019003384 active site 536019003385 I-site; other site 536019003386 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019003387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019003388 metal binding site [ion binding]; metal-binding site 536019003389 active site 536019003390 I-site; other site 536019003391 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 536019003392 Iron-sulfur protein interface; other site 536019003393 proximal quinone binding site [chemical binding]; other site 536019003394 SdhD (CybS) interface [polypeptide binding]; other site 536019003395 proximal heme binding site [chemical binding]; other site 536019003396 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 536019003397 putative SdhC subunit interface [polypeptide binding]; other site 536019003398 putative proximal heme binding site [chemical binding]; other site 536019003399 putative Iron-sulfur protein interface [polypeptide binding]; other site 536019003400 putative proximal quinone binding site; other site 536019003401 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 536019003402 L-aspartate oxidase; Provisional; Region: PRK06175 536019003403 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 536019003404 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 536019003405 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 536019003406 Protein of unknown function, DUF480; Region: DUF480; cl01209 536019003407 hypothetical protein; Provisional; Region: PRK11239 536019003408 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 536019003409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 536019003410 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 536019003411 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019003412 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 536019003413 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 536019003414 active site 536019003415 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 536019003416 catalytic triad [active] 536019003417 dimer interface [polypeptide binding]; other site 536019003418 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 536019003419 Nitrogen regulatory protein P-II; Region: P-II; smart00938 536019003420 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 536019003421 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 536019003422 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 536019003423 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 536019003424 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 536019003425 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 536019003426 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 536019003427 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 536019003428 putative catalytic site [active] 536019003429 putative phosphate binding site [ion binding]; other site 536019003430 active site 536019003431 metal binding site A [ion binding]; metal-binding site 536019003432 DNA binding site [nucleotide binding] 536019003433 putative AP binding site [nucleotide binding]; other site 536019003434 putative metal binding site B [ion binding]; other site 536019003435 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 536019003436 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019003437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019003438 ligand binding site [chemical binding]; other site 536019003439 flexible hinge region; other site 536019003440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019003441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019003442 active site 536019003443 phosphorylation site [posttranslational modification] 536019003444 intermolecular recognition site; other site 536019003445 dimerization interface [polypeptide binding]; other site 536019003446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019003447 DNA binding site [nucleotide binding] 536019003448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 536019003449 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019003450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019003451 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019003452 dimerization interface [polypeptide binding]; other site 536019003453 substrate binding pocket [chemical binding]; other site 536019003454 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 536019003455 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 536019003456 Predicted methyltransferase [General function prediction only]; Region: COG3897 536019003457 Uncharacterized conserved protein [Function unknown]; Region: COG2947 536019003458 YciI-like protein; Reviewed; Region: PRK12865 536019003459 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 536019003460 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 536019003461 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 536019003462 UGMP family protein; Validated; Region: PRK09604 536019003463 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 536019003464 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 536019003465 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 536019003466 domain interfaces; other site 536019003467 active site 536019003468 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 536019003469 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 536019003470 active site 536019003471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 536019003472 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 536019003473 HemY protein N-terminus; Region: HemY_N; pfam07219 536019003474 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 536019003475 putative metal binding site [ion binding]; other site 536019003476 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 536019003477 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 536019003478 catalytic triad [active] 536019003479 enterobactin exporter EntS; Provisional; Region: PRK10489 536019003480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019003481 putative substrate translocation pore; other site 536019003482 transaminase; Validated; Region: PRK07324 536019003483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019003484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019003485 homodimer interface [polypeptide binding]; other site 536019003486 catalytic residue [active] 536019003487 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 536019003488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019003489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019003490 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 536019003491 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 536019003492 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 536019003493 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 536019003494 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019003495 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 536019003496 Domain interface; other site 536019003497 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 536019003498 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 536019003499 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 536019003500 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019003501 putative ligand binding site [chemical binding]; other site 536019003502 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019003503 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019003504 Walker A/P-loop; other site 536019003505 ATP binding site [chemical binding]; other site 536019003506 Q-loop/lid; other site 536019003507 ABC transporter signature motif; other site 536019003508 Walker B; other site 536019003509 D-loop; other site 536019003510 H-loop/switch region; other site 536019003511 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019003512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019003513 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019003514 TM-ABC transporter signature motif; other site 536019003515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019003516 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019003517 TM-ABC transporter signature motif; other site 536019003518 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 536019003519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019003520 substrate binding site [chemical binding]; other site 536019003521 oxyanion hole (OAH) forming residues; other site 536019003522 trimer interface [polypeptide binding]; other site 536019003523 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019003524 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019003525 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019003526 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019003527 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019003528 NAD(P) binding site [chemical binding]; other site 536019003529 catalytic residues [active] 536019003530 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019003531 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019003532 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019003533 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 536019003534 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 536019003535 active site 536019003536 TDP-binding site; other site 536019003537 acceptor substrate-binding pocket; other site 536019003538 homodimer interface [polypeptide binding]; other site 536019003539 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019003540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019003541 Walker A/P-loop; other site 536019003542 ATP binding site [chemical binding]; other site 536019003543 Q-loop/lid; other site 536019003544 ABC transporter signature motif; other site 536019003545 Walker B; other site 536019003546 D-loop; other site 536019003547 H-loop/switch region; other site 536019003548 TOBE domain; Region: TOBE_2; pfam08402 536019003549 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019003550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003551 dimer interface [polypeptide binding]; other site 536019003552 conserved gate region; other site 536019003553 putative PBP binding loops; other site 536019003554 ABC-ATPase subunit interface; other site 536019003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003556 putative PBP binding loops; other site 536019003557 ABC-ATPase subunit interface; other site 536019003558 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536019003559 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536019003560 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 536019003561 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 536019003562 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019003563 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019003564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019003565 DNA-binding site [nucleotide binding]; DNA binding site 536019003566 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019003567 FCD domain; Region: FCD; pfam07729 536019003568 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 536019003569 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 536019003570 homodimer interface [polypeptide binding]; other site 536019003571 active site 536019003572 TDP-binding site; other site 536019003573 acceptor substrate-binding pocket; other site 536019003574 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536019003575 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019003576 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019003577 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019003578 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 536019003579 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536019003580 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019003581 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 536019003582 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 536019003583 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 536019003584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536019003585 dimer interface [polypeptide binding]; other site 536019003586 active site 536019003587 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 536019003588 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 536019003589 putative ligand binding site [chemical binding]; other site 536019003590 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 536019003591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019003592 Walker A/P-loop; other site 536019003593 ATP binding site [chemical binding]; other site 536019003594 Q-loop/lid; other site 536019003595 ABC transporter signature motif; other site 536019003596 Walker B; other site 536019003597 D-loop; other site 536019003598 H-loop/switch region; other site 536019003599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019003600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019003601 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019003602 TM-ABC transporter signature motif; other site 536019003603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019003604 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019003605 TM-ABC transporter signature motif; other site 536019003606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019003607 classical (c) SDRs; Region: SDR_c; cd05233 536019003608 NAD(P) binding site [chemical binding]; other site 536019003609 active site 536019003610 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 536019003611 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536019003612 Isochorismatase family; Region: Isochorismatase; pfam00857 536019003613 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019003614 catalytic triad [active] 536019003615 conserved cis-peptide bond; other site 536019003616 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 536019003617 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536019003618 Walker A/P-loop; other site 536019003619 ATP binding site [chemical binding]; other site 536019003620 Q-loop/lid; other site 536019003621 ABC transporter signature motif; other site 536019003622 Walker B; other site 536019003623 D-loop; other site 536019003624 H-loop/switch region; other site 536019003625 tonB-system energizer ExbB; Region: exbB; TIGR02797 536019003626 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 536019003627 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 536019003628 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 536019003629 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 536019003630 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 536019003631 putative FMN binding site [chemical binding]; other site 536019003632 NADPH bind site [chemical binding]; other site 536019003633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019003634 non-specific DNA binding site [nucleotide binding]; other site 536019003635 salt bridge; other site 536019003636 sequence-specific DNA binding site [nucleotide binding]; other site 536019003637 YGGT family; Region: YGGT; pfam02325 536019003638 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 536019003639 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019003640 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019003641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019003642 putative active site [active] 536019003643 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019003644 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019003645 Walker A/P-loop; other site 536019003646 ATP binding site [chemical binding]; other site 536019003647 Q-loop/lid; other site 536019003648 ABC transporter signature motif; other site 536019003649 Walker B; other site 536019003650 D-loop; other site 536019003651 H-loop/switch region; other site 536019003652 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 536019003653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003654 NAD(P) binding site [chemical binding]; other site 536019003655 active site 536019003656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019003657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019003658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019003659 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019003660 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019003661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003662 conserved gate region; other site 536019003663 dimer interface [polypeptide binding]; other site 536019003664 putative PBP binding loops; other site 536019003665 ABC-ATPase subunit interface; other site 536019003666 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019003668 dimer interface [polypeptide binding]; other site 536019003669 conserved gate region; other site 536019003670 ABC-ATPase subunit interface; other site 536019003671 Uncharacterized conserved protein [Function unknown]; Region: COG5476 536019003672 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 536019003673 MlrC C-terminus; Region: MlrC_C; pfam07171 536019003674 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 536019003675 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 536019003676 active site 536019003677 Zn binding site [ion binding]; other site 536019003678 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 536019003679 active site clefts [active] 536019003680 zinc binding site [ion binding]; other site 536019003681 dimer interface [polypeptide binding]; other site 536019003682 Protein of unknown function (DUF429); Region: DUF429; cl12046 536019003683 pyridoxamine kinase; Validated; Region: PRK05756 536019003684 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 536019003685 pyridoxal binding site [chemical binding]; other site 536019003686 dimer interface [polypeptide binding]; other site 536019003687 ATP binding site [chemical binding]; other site 536019003688 LemA family; Region: LemA; pfam04011 536019003689 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 536019003690 Repair protein; Region: Repair_PSII; pfam04536 536019003691 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 536019003692 Repair protein; Region: Repair_PSII; pfam04536 536019003693 Predicted membrane protein [Function unknown]; Region: COG3762 536019003694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019003695 Coenzyme A binding pocket [chemical binding]; other site 536019003696 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 536019003697 dimer interface [polypeptide binding]; other site 536019003698 substrate binding site [chemical binding]; other site 536019003699 metal binding sites [ion binding]; metal-binding site 536019003700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019003701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019003702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019003703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019003704 putative substrate translocation pore; other site 536019003705 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 536019003706 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 536019003707 putative active site [active] 536019003708 putative metal binding site [ion binding]; other site 536019003709 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 536019003710 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 536019003711 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 536019003712 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 536019003713 G1 box; other site 536019003714 putative GEF interaction site [polypeptide binding]; other site 536019003715 GTP/Mg2+ binding site [chemical binding]; other site 536019003716 Switch I region; other site 536019003717 G2 box; other site 536019003718 G3 box; other site 536019003719 Switch II region; other site 536019003720 G4 box; other site 536019003721 G5 box; other site 536019003722 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 536019003723 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 536019003724 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 536019003725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019003726 YCII-related domain; Region: YCII; cl00999 536019003727 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 536019003728 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 536019003729 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 536019003730 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 536019003731 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 536019003732 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 536019003733 purine monophosphate binding site [chemical binding]; other site 536019003734 dimer interface [polypeptide binding]; other site 536019003735 putative catalytic residues [active] 536019003736 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 536019003737 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 536019003738 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 536019003739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 536019003740 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 536019003741 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 536019003742 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 536019003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019003744 S-adenosylmethionine binding site [chemical binding]; other site 536019003745 heat shock protein HtpX; Provisional; Region: PRK01345 536019003746 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019003747 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019003748 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 536019003749 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019003750 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 536019003751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019003752 S-adenosylmethionine binding site [chemical binding]; other site 536019003753 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 536019003754 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 536019003755 MOSC domain; Region: MOSC; pfam03473 536019003756 acetyl-CoA synthetase; Provisional; Region: PRK00174 536019003757 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 536019003758 active site 536019003759 CoA binding site [chemical binding]; other site 536019003760 acyl-activating enzyme (AAE) consensus motif; other site 536019003761 AMP binding site [chemical binding]; other site 536019003762 acetate binding site [chemical binding]; other site 536019003763 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 536019003764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019003765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019003766 active site 536019003767 catalytic tetrad [active] 536019003768 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019003769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019003770 putative substrate translocation pore; other site 536019003771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019003772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019003773 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 536019003774 putative effector binding pocket; other site 536019003775 putative dimerization interface [polypeptide binding]; other site 536019003776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019003777 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019003778 active site 536019003779 catalytic tetrad [active] 536019003780 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 536019003781 oligomeric interface; other site 536019003782 putative active site [active] 536019003783 homodimer interface [polypeptide binding]; other site 536019003784 prevent-host-death family protein; Region: phd_fam; TIGR01552 536019003785 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 536019003786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019003787 catalytic residue [active] 536019003788 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 536019003789 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 536019003790 HIGH motif; other site 536019003791 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 536019003792 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536019003793 active site 536019003794 KMSKS motif; other site 536019003795 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 536019003796 tRNA binding surface [nucleotide binding]; other site 536019003797 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 536019003798 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 536019003799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 536019003800 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 536019003801 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 536019003802 active site 536019003803 intersubunit interactions; other site 536019003804 catalytic residue [active] 536019003805 primosome assembly protein PriA; Validated; Region: PRK05580 536019003806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019003807 ATP binding site [chemical binding]; other site 536019003808 putative Mg++ binding site [ion binding]; other site 536019003809 helicase superfamily c-terminal domain; Region: HELICc; smart00490 536019003810 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 536019003811 aspartate racemase; Region: asp_race; TIGR00035 536019003812 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 536019003813 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 536019003814 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 536019003815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 536019003816 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 536019003817 beta subunit interaction interface [polypeptide binding]; other site 536019003818 Walker A motif; other site 536019003819 ATP binding site [chemical binding]; other site 536019003820 Walker B motif; other site 536019003821 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 536019003822 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 536019003823 core domain interface [polypeptide binding]; other site 536019003824 delta subunit interface [polypeptide binding]; other site 536019003825 epsilon subunit interface [polypeptide binding]; other site 536019003826 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 536019003827 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 536019003828 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 536019003829 alpha subunit interaction interface [polypeptide binding]; other site 536019003830 Walker A motif; other site 536019003831 ATP binding site [chemical binding]; other site 536019003832 Walker B motif; other site 536019003833 inhibitor binding site; inhibition site 536019003834 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 536019003835 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 536019003836 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 536019003837 gamma subunit interface [polypeptide binding]; other site 536019003838 epsilon subunit interface [polypeptide binding]; other site 536019003839 LBP interface [polypeptide binding]; other site 536019003840 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 536019003841 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536019003842 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536019003843 glucuronate isomerase; Reviewed; Region: PRK02925 536019003844 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 536019003845 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 536019003846 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 536019003847 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 536019003848 DctM-like transporters; Region: DctM; pfam06808 536019003849 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 536019003850 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019003851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019003852 DNA-binding site [nucleotide binding]; DNA binding site 536019003853 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536019003854 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 536019003855 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 536019003856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003857 NAD(P) binding site [chemical binding]; other site 536019003858 active site 536019003859 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019003860 Cupin domain; Region: Cupin_2; cl17218 536019003861 Cupin; Region: Cupin_6; pfam12852 536019003862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019003863 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019003864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019003865 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 536019003866 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 536019003867 NAD(P) binding site [chemical binding]; other site 536019003868 catalytic residues [active] 536019003869 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 536019003870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019003871 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 536019003872 dimerization interface [polypeptide binding]; other site 536019003873 substrate binding pocket [chemical binding]; other site 536019003874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019003875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003876 NAD(P) binding site [chemical binding]; other site 536019003877 active site 536019003878 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 536019003879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019003880 ATP binding site [chemical binding]; other site 536019003881 putative Mg++ binding site [ion binding]; other site 536019003882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019003883 nucleotide binding region [chemical binding]; other site 536019003884 ATP-binding site [chemical binding]; other site 536019003885 RQC domain; Region: RQC; pfam09382 536019003886 HRDC domain; Region: HRDC; pfam00570 536019003887 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 536019003888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019003889 NAD(P) binding site [chemical binding]; other site 536019003890 active site 536019003891 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 536019003892 Autotransporter beta-domain; Region: Autotransporter; smart00869 536019003893 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019003894 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 536019003895 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 536019003896 Uncharacterized conserved protein [Function unknown]; Region: COG3743 536019003897 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 536019003898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019003899 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 536019003900 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 536019003901 putative catalytic site [active] 536019003902 putative metal binding site [ion binding]; other site 536019003903 putative phosphate binding site [ion binding]; other site 536019003904 GTPase CgtA; Reviewed; Region: obgE; PRK12299 536019003905 GTP1/OBG; Region: GTP1_OBG; pfam01018 536019003906 Obg GTPase; Region: Obg; cd01898 536019003907 G1 box; other site 536019003908 GTP/Mg2+ binding site [chemical binding]; other site 536019003909 Switch I region; other site 536019003910 G2 box; other site 536019003911 G3 box; other site 536019003912 Switch II region; other site 536019003913 G4 box; other site 536019003914 G5 box; other site 536019003915 gamma-glutamyl kinase; Provisional; Region: PRK05429 536019003916 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 536019003917 nucleotide binding site [chemical binding]; other site 536019003918 homotetrameric interface [polypeptide binding]; other site 536019003919 putative phosphate binding site [ion binding]; other site 536019003920 putative allosteric binding site; other site 536019003921 PUA domain; Region: PUA; pfam01472 536019003922 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 536019003923 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 536019003924 putative catalytic cysteine [active] 536019003925 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 536019003926 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 536019003927 active site 536019003928 (T/H)XGH motif; other site 536019003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019003930 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536019003931 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 536019003932 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 536019003933 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 536019003934 Peptidase family M23; Region: Peptidase_M23; pfam01551 536019003935 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 536019003936 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 536019003937 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 536019003938 protein binding site [polypeptide binding]; other site 536019003939 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 536019003940 Catalytic dyad [active] 536019003941 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 536019003942 NodB motif; other site 536019003943 putative active site [active] 536019003944 putative catalytic site [active] 536019003945 Zn binding site [ion binding]; other site 536019003946 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 536019003947 putative active site [active] 536019003948 Ap4A binding site [chemical binding]; other site 536019003949 nudix motif; other site 536019003950 putative metal binding site [ion binding]; other site 536019003951 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 536019003952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 536019003953 active site 536019003954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019003955 dimer interface [polypeptide binding]; other site 536019003956 substrate binding site [chemical binding]; other site 536019003957 catalytic residues [active] 536019003958 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 536019003959 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536019003960 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 536019003961 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 536019003962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019003963 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 536019003964 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 536019003965 putative active site [active] 536019003966 catalytic site [active] 536019003967 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 536019003968 putative active site [active] 536019003969 catalytic site [active] 536019003970 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 536019003971 primary metal binding site; other site 536019003972 catalytic residues [active] 536019003973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019003974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019003975 LysR substrate binding domain; Region: LysR_substrate; pfam03466 536019003976 dimerization interface [polypeptide binding]; other site 536019003977 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 536019003978 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 536019003979 tetrameric interface [polypeptide binding]; other site 536019003980 NAD binding site [chemical binding]; other site 536019003981 catalytic residues [active] 536019003982 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019003983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019003984 DNA-binding site [nucleotide binding]; DNA binding site 536019003985 FCD domain; Region: FCD; pfam07729 536019003986 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 536019003987 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 536019003988 inhibitor site; inhibition site 536019003989 active site 536019003990 dimer interface [polypeptide binding]; other site 536019003991 catalytic residue [active] 536019003992 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 536019003993 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 536019003994 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 536019003995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019003996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019003997 TM-ABC transporter signature motif; other site 536019003998 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 536019003999 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019004000 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019004001 TM-ABC transporter signature motif; other site 536019004002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019004003 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019004004 Walker A/P-loop; other site 536019004005 ATP binding site [chemical binding]; other site 536019004006 Q-loop/lid; other site 536019004007 ABC transporter signature motif; other site 536019004008 Walker B; other site 536019004009 D-loop; other site 536019004010 H-loop/switch region; other site 536019004011 Uncharacterized conserved protein [Function unknown]; Region: COG3743 536019004012 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019004013 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019004014 Walker A/P-loop; other site 536019004015 ATP binding site [chemical binding]; other site 536019004016 Q-loop/lid; other site 536019004017 ABC transporter signature motif; other site 536019004018 Walker B; other site 536019004019 D-loop; other site 536019004020 H-loop/switch region; other site 536019004021 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019004022 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 536019004023 dimerization interface [polypeptide binding]; other site 536019004024 ligand binding site [chemical binding]; other site 536019004025 pyruvate carboxylase; Reviewed; Region: PRK12999 536019004026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019004027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019004028 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536019004029 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 536019004030 active site 536019004031 catalytic residues [active] 536019004032 metal binding site [ion binding]; metal-binding site 536019004033 homodimer binding site [polypeptide binding]; other site 536019004034 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536019004035 carboxyltransferase (CT) interaction site; other site 536019004036 biotinylation site [posttranslational modification]; other site 536019004037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 536019004038 methionine sulfoxide reductase B; Provisional; Region: PRK00222 536019004039 SelR domain; Region: SelR; pfam01641 536019004040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 536019004041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536019004042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019004043 Coenzyme A binding pocket [chemical binding]; other site 536019004044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019004045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019004046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019004047 dimerization interface [polypeptide binding]; other site 536019004048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019004049 putative substrate translocation pore; other site 536019004050 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 536019004051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019004052 Walker A motif; other site 536019004053 ATP binding site [chemical binding]; other site 536019004054 Walker B motif; other site 536019004055 arginine finger; other site 536019004056 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 536019004057 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 536019004058 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 536019004059 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019004060 putative active site [active] 536019004061 metal binding site [ion binding]; metal-binding site 536019004062 homodimer binding site [polypeptide binding]; other site 536019004063 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 536019004064 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 536019004065 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 536019004066 putative hydrophobic ligand binding site [chemical binding]; other site 536019004067 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 536019004068 dimer interface [polypeptide binding]; other site 536019004069 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 536019004070 hydrophobic ligand binding site; other site 536019004071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019004072 dimerization interface [polypeptide binding]; other site 536019004073 putative DNA binding site [nucleotide binding]; other site 536019004074 putative Zn2+ binding site [ion binding]; other site 536019004075 hypothetical protein; Validated; Region: PRK00110 536019004076 Rdx family; Region: Rdx; cl01407 536019004077 Predicted integral membrane protein [Function unknown]; Region: COG5500 536019004078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019004079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019004080 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 536019004081 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 536019004082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019004083 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 536019004084 Walker A/P-loop; other site 536019004085 ATP binding site [chemical binding]; other site 536019004086 Q-loop/lid; other site 536019004087 ABC transporter signature motif; other site 536019004088 Walker B; other site 536019004089 D-loop; other site 536019004090 H-loop/switch region; other site 536019004091 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 536019004092 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 536019004093 active site 536019004094 Zn binding site [ion binding]; other site 536019004095 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 536019004096 hypothetical protein; Validated; Region: PRK09039 536019004097 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536019004098 ligand binding site [chemical binding]; other site 536019004099 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 536019004100 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019004101 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 536019004102 active site 536019004103 dimerization interface [polypeptide binding]; other site 536019004104 elongation factor P; Validated; Region: PRK00529 536019004105 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 536019004106 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 536019004107 RNA binding site [nucleotide binding]; other site 536019004108 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 536019004109 RNA binding site [nucleotide binding]; other site 536019004110 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536019004111 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 536019004112 thiamine phosphate binding site [chemical binding]; other site 536019004113 active site 536019004114 pyrophosphate binding site [ion binding]; other site 536019004115 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536019004116 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019004117 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 536019004118 AsnC family; Region: AsnC_trans_reg; pfam01037 536019004119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019004120 S-adenosylmethionine binding site [chemical binding]; other site 536019004121 Predicted permeases [General function prediction only]; Region: COG0730 536019004122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 536019004123 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 536019004124 active site 536019004125 putative DNA-binding cleft [nucleotide binding]; other site 536019004126 dimer interface [polypeptide binding]; other site 536019004127 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 536019004128 RuvA N terminal domain; Region: RuvA_N; pfam01330 536019004129 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 536019004130 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 536019004131 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 536019004132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019004133 Walker A motif; other site 536019004134 ATP binding site [chemical binding]; other site 536019004135 Walker B motif; other site 536019004136 arginine finger; other site 536019004137 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 536019004138 phosphodiesterase YaeI; Provisional; Region: PRK11340 536019004139 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 536019004140 putative active site [active] 536019004141 putative metal binding site [ion binding]; other site 536019004142 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 536019004143 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536019004144 active site 536019004145 TolQ protein; Region: tolQ; TIGR02796 536019004146 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 536019004147 TolR protein; Region: tolR; TIGR02801 536019004148 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 536019004149 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 536019004150 translocation protein TolB; Provisional; Region: tolB; PRK05137 536019004151 TolB amino-terminal domain; Region: TolB_N; pfam04052 536019004152 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536019004153 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536019004154 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536019004155 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536019004156 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 536019004157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536019004158 ligand binding site [chemical binding]; other site 536019004159 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 536019004160 DEAD/H associated; Region: DEAD_assoc; pfam08494 536019004161 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 536019004162 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 536019004163 Ligand Binding Site [chemical binding]; other site 536019004164 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 536019004165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019004166 Walker A motif; other site 536019004167 ATP binding site [chemical binding]; other site 536019004168 Walker B motif; other site 536019004169 arginine finger; other site 536019004170 Peptidase family M41; Region: Peptidase_M41; pfam01434 536019004171 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 536019004172 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 536019004173 active site 536019004174 substrate binding site [chemical binding]; other site 536019004175 metal binding site [ion binding]; metal-binding site 536019004176 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019004177 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019004178 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 536019004179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019004180 catalytic residue [active] 536019004181 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 536019004182 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 536019004183 ligand binding site [chemical binding]; other site 536019004184 NAD binding site [chemical binding]; other site 536019004185 dimerization interface [polypeptide binding]; other site 536019004186 catalytic site [active] 536019004187 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 536019004188 putative L-serine binding site [chemical binding]; other site 536019004189 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019004190 EamA-like transporter family; Region: EamA; pfam00892 536019004191 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 536019004192 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 536019004193 GDP-binding site [chemical binding]; other site 536019004194 ACT binding site; other site 536019004195 IMP binding site; other site 536019004196 CcdB protein; Region: CcdB; cl03380 536019004197 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 536019004198 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 536019004199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019004200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019004201 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 536019004202 Thiamine pyrophosphokinase; Region: TPK; cd07995 536019004203 active site 536019004204 dimerization interface [polypeptide binding]; other site 536019004205 thiamine binding site [chemical binding]; other site 536019004206 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 536019004207 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 536019004208 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 536019004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004210 dimer interface [polypeptide binding]; other site 536019004211 conserved gate region; other site 536019004212 ABC-ATPase subunit interface; other site 536019004213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004214 dimer interface [polypeptide binding]; other site 536019004215 conserved gate region; other site 536019004216 putative PBP binding loops; other site 536019004217 ABC-ATPase subunit interface; other site 536019004218 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 536019004219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019004220 Walker A/P-loop; other site 536019004221 ATP binding site [chemical binding]; other site 536019004222 Q-loop/lid; other site 536019004223 ABC transporter signature motif; other site 536019004224 Walker B; other site 536019004225 D-loop; other site 536019004226 H-loop/switch region; other site 536019004227 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 536019004228 Peptidase family M48; Region: Peptidase_M48; pfam01435 536019004229 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 536019004230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019004231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019004232 DNA binding residues [nucleotide binding] 536019004233 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019004234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019004235 substrate binding pocket [chemical binding]; other site 536019004236 membrane-bound complex binding site; other site 536019004237 hinge residues; other site 536019004238 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019004239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004240 dimer interface [polypeptide binding]; other site 536019004241 conserved gate region; other site 536019004242 putative PBP binding loops; other site 536019004243 ABC-ATPase subunit interface; other site 536019004244 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019004245 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019004246 Walker A/P-loop; other site 536019004247 ATP binding site [chemical binding]; other site 536019004248 Q-loop/lid; other site 536019004249 ABC transporter signature motif; other site 536019004250 Walker B; other site 536019004251 D-loop; other site 536019004252 H-loop/switch region; other site 536019004253 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 536019004254 Ferredoxin [Energy production and conversion]; Region: COG1146 536019004255 4Fe-4S binding domain; Region: Fer4; pfam00037 536019004256 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 536019004257 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019004258 RNA binding surface [nucleotide binding]; other site 536019004259 DEAD/DEAH box helicase; Region: DEAD; pfam00270 536019004260 ATP binding site [chemical binding]; other site 536019004261 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 536019004262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019004263 nucleotide binding region [chemical binding]; other site 536019004264 ATP-binding site [chemical binding]; other site 536019004265 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 536019004266 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 536019004267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019004268 NAD(P) binding site [chemical binding]; other site 536019004269 active site 536019004270 putative acyltransferase; Provisional; Region: PRK05790 536019004271 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536019004272 dimer interface [polypeptide binding]; other site 536019004273 active site 536019004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 536019004275 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 536019004276 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 536019004277 Helix-turn-helix domain; Region: HTH_17; pfam12728 536019004278 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 536019004279 dimer interface [polypeptide binding]; other site 536019004280 active site 536019004281 coenzyme A binding site [chemical binding]; other site 536019004282 citrylCoA binding site [chemical binding]; other site 536019004283 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 536019004284 oxalacetate/citrate binding site [chemical binding]; other site 536019004285 catalytic triad [active] 536019004286 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 536019004287 dimer interface [polypeptide binding]; other site 536019004288 Citrate synthase; Region: Citrate_synt; pfam00285 536019004289 active site 536019004290 citrylCoA binding site [chemical binding]; other site 536019004291 oxalacetate/citrate binding site [chemical binding]; other site 536019004292 coenzyme A binding site [chemical binding]; other site 536019004293 catalytic triad [active] 536019004294 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 536019004295 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 536019004296 active site 536019004297 nucleophile elbow; other site 536019004298 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019004299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019004300 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019004301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019004302 Protein export membrane protein; Region: SecD_SecF; cl14618 536019004303 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 536019004304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019004305 putative NAD(P) binding site [chemical binding]; other site 536019004306 putative active site [active] 536019004307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019004308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019004309 LysR substrate binding domain; Region: LysR_substrate; pfam03466 536019004310 dimerization interface [polypeptide binding]; other site 536019004311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 536019004313 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 536019004314 Predicted integral membrane protein [Function unknown]; Region: COG5480 536019004315 pyruvate kinase; Provisional; Region: PRK06247 536019004316 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 536019004317 domain interfaces; other site 536019004318 active site 536019004319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019004320 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 536019004321 catalytic site [active] 536019004322 TPR repeat; Region: TPR_11; pfam13414 536019004323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019004324 binding surface 536019004325 TPR motif; other site 536019004326 TPR repeat; Region: TPR_11; pfam13414 536019004327 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 536019004328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 536019004329 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 536019004330 ATP-grasp domain; Region: ATP-grasp; pfam02222 536019004331 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 536019004332 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 536019004333 RNA polymerase sigma factor; Provisional; Region: PRK11924 536019004334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019004335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019004336 DNA binding residues [nucleotide binding] 536019004337 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 536019004338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019004339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019004340 catalytic residue [active] 536019004341 catalytic residue [active] 536019004342 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 536019004343 homotrimer interaction site [polypeptide binding]; other site 536019004344 putative active site [active] 536019004345 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019004346 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019004347 Walker A/P-loop; other site 536019004348 ATP binding site [chemical binding]; other site 536019004349 Q-loop/lid; other site 536019004350 ABC transporter signature motif; other site 536019004351 Walker B; other site 536019004352 D-loop; other site 536019004353 H-loop/switch region; other site 536019004354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004355 dimer interface [polypeptide binding]; other site 536019004356 conserved gate region; other site 536019004357 putative PBP binding loops; other site 536019004358 ABC-ATPase subunit interface; other site 536019004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004360 dimer interface [polypeptide binding]; other site 536019004361 conserved gate region; other site 536019004362 putative PBP binding loops; other site 536019004363 ABC-ATPase subunit interface; other site 536019004364 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019004365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019004366 substrate binding pocket [chemical binding]; other site 536019004367 membrane-bound complex binding site; other site 536019004368 hinge residues; other site 536019004369 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536019004370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019004371 putative DNA binding site [nucleotide binding]; other site 536019004372 putative Zn2+ binding site [ion binding]; other site 536019004373 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019004374 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 536019004375 Uncharacterized small protein [Function unknown]; Region: COG5570 536019004376 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 536019004377 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 536019004378 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 536019004379 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019004380 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019004381 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019004382 catalytic residue [active] 536019004383 Sporulation related domain; Region: SPOR; pfam05036 536019004384 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 536019004385 P-loop motif; other site 536019004386 ATP binding site [chemical binding]; other site 536019004387 Chloramphenicol (Cm) binding site [chemical binding]; other site 536019004388 catalytic residue [active] 536019004389 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 536019004390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019004391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019004392 dimer interface [polypeptide binding]; other site 536019004393 phosphorylation site [posttranslational modification] 536019004394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019004395 ATP binding site [chemical binding]; other site 536019004396 Mg2+ binding site [ion binding]; other site 536019004397 G-X-G motif; other site 536019004398 Response regulator receiver domain; Region: Response_reg; pfam00072 536019004399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004400 active site 536019004401 phosphorylation site [posttranslational modification] 536019004402 intermolecular recognition site; other site 536019004403 dimerization interface [polypeptide binding]; other site 536019004404 Response regulator receiver domain; Region: Response_reg; pfam00072 536019004405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004406 active site 536019004407 phosphorylation site [posttranslational modification] 536019004408 intermolecular recognition site; other site 536019004409 dimerization interface [polypeptide binding]; other site 536019004410 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 536019004411 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 536019004412 NADP binding site [chemical binding]; other site 536019004413 homodimer interface [polypeptide binding]; other site 536019004414 active site 536019004415 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 536019004416 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 536019004417 substrate binding pocket [chemical binding]; other site 536019004418 aspartate-rich region 1; other site 536019004419 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 536019004420 Transglycosylase; Region: Transgly; pfam00912 536019004421 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 536019004422 agmatinase; Region: agmatinase; TIGR01230 536019004423 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 536019004424 active site 536019004425 metal binding site [ion binding]; metal-binding site 536019004426 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 536019004427 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019004428 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019004429 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019004430 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 536019004431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019004432 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536019004433 C-terminal domain interface [polypeptide binding]; other site 536019004434 GSH binding site (G-site) [chemical binding]; other site 536019004435 dimer interface [polypeptide binding]; other site 536019004436 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 536019004437 N-terminal domain interface [polypeptide binding]; other site 536019004438 dimer interface [polypeptide binding]; other site 536019004439 substrate binding pocket (H-site) [chemical binding]; other site 536019004440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019004441 dimerization interface [polypeptide binding]; other site 536019004442 putative DNA binding site [nucleotide binding]; other site 536019004443 putative Zn2+ binding site [ion binding]; other site 536019004444 putative MFS family transporter protein; Provisional; Region: PRK03633 536019004445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019004446 putative substrate translocation pore; other site 536019004447 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 536019004448 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 536019004449 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 536019004450 NAD(P) binding site [chemical binding]; other site 536019004451 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 536019004453 Predicted transcriptional regulator [Transcription]; Region: COG2378 536019004454 HTH domain; Region: HTH_11; pfam08279 536019004455 WYL domain; Region: WYL; pfam13280 536019004456 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 536019004457 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 536019004458 conserved cys residue [active] 536019004459 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 536019004460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019004461 Zn binding site [ion binding]; other site 536019004462 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 536019004463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019004464 Zn binding site [ion binding]; other site 536019004465 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 536019004466 active site 536019004467 catalytic triad [active] 536019004468 oxyanion hole [active] 536019004469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 536019004470 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 536019004471 active site 536019004472 intersubunit interface [polypeptide binding]; other site 536019004473 catalytic residue [active] 536019004474 Phosphoglycerate kinase; Region: PGK; pfam00162 536019004475 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 536019004476 substrate binding site [chemical binding]; other site 536019004477 hinge regions; other site 536019004478 ADP binding site [chemical binding]; other site 536019004479 catalytic site [active] 536019004480 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 536019004481 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 536019004482 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 536019004483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 536019004484 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 536019004485 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 536019004486 TPP-binding site [chemical binding]; other site 536019004487 dimer interface [polypeptide binding]; other site 536019004488 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536019004489 PYR/PP interface [polypeptide binding]; other site 536019004490 dimer interface [polypeptide binding]; other site 536019004491 TPP binding site [chemical binding]; other site 536019004492 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019004493 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 536019004494 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 536019004495 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 536019004496 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 536019004497 dimer interface [polypeptide binding]; other site 536019004498 decamer (pentamer of dimers) interface [polypeptide binding]; other site 536019004499 catalytic triad [active] 536019004500 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536019004501 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 536019004502 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 536019004503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019004504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019004505 DNA binding residues [nucleotide binding] 536019004506 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 536019004507 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019004508 RNA binding surface [nucleotide binding]; other site 536019004509 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 536019004510 active site 536019004511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019004512 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 536019004513 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 536019004514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019004515 Zn binding site [ion binding]; other site 536019004516 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019004517 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 536019004518 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 536019004519 N-terminal domain interface [polypeptide binding]; other site 536019004520 dimer interface [polypeptide binding]; other site 536019004521 substrate binding pocket (H-site) [chemical binding]; other site 536019004522 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 536019004523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019004524 PAS domain; Region: PAS_9; pfam13426 536019004525 putative active site [active] 536019004526 heme pocket [chemical binding]; other site 536019004527 PAS fold; Region: PAS_7; pfam12860 536019004528 PAS fold; Region: PAS_7; pfam12860 536019004529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019004530 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019004531 putative active site [active] 536019004532 heme pocket [chemical binding]; other site 536019004533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019004534 putative active site [active] 536019004535 heme pocket [chemical binding]; other site 536019004536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019004537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019004538 dimer interface [polypeptide binding]; other site 536019004539 phosphorylation site [posttranslational modification] 536019004540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019004541 ATP binding site [chemical binding]; other site 536019004542 Mg2+ binding site [ion binding]; other site 536019004543 G-X-G motif; other site 536019004544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019004545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004546 active site 536019004547 phosphorylation site [posttranslational modification] 536019004548 intermolecular recognition site; other site 536019004549 dimerization interface [polypeptide binding]; other site 536019004550 Response regulator receiver domain; Region: Response_reg; pfam00072 536019004551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004552 active site 536019004553 phosphorylation site [posttranslational modification] 536019004554 intermolecular recognition site; other site 536019004555 dimerization interface [polypeptide binding]; other site 536019004556 PBP superfamily domain; Region: PBP_like_2; cl17296 536019004557 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 536019004558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004559 dimer interface [polypeptide binding]; other site 536019004560 conserved gate region; other site 536019004561 putative PBP binding loops; other site 536019004562 ABC-ATPase subunit interface; other site 536019004563 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 536019004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004565 dimer interface [polypeptide binding]; other site 536019004566 conserved gate region; other site 536019004567 putative PBP binding loops; other site 536019004568 ABC-ATPase subunit interface; other site 536019004569 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 536019004570 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 536019004571 Walker A/P-loop; other site 536019004572 ATP binding site [chemical binding]; other site 536019004573 Q-loop/lid; other site 536019004574 ABC transporter signature motif; other site 536019004575 Walker B; other site 536019004576 D-loop; other site 536019004577 H-loop/switch region; other site 536019004578 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 536019004579 PhoU domain; Region: PhoU; pfam01895 536019004580 PhoU domain; Region: PhoU; pfam01895 536019004581 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 536019004582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004583 active site 536019004584 phosphorylation site [posttranslational modification] 536019004585 intermolecular recognition site; other site 536019004586 dimerization interface [polypeptide binding]; other site 536019004587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019004588 DNA binding site [nucleotide binding] 536019004589 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019004590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019004591 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 536019004592 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 536019004593 putative ligand binding site [chemical binding]; other site 536019004594 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019004595 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019004596 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019004597 TM-ABC transporter signature motif; other site 536019004598 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019004599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019004600 Walker A/P-loop; other site 536019004601 ATP binding site [chemical binding]; other site 536019004602 Q-loop/lid; other site 536019004603 ABC transporter signature motif; other site 536019004604 Walker B; other site 536019004605 D-loop; other site 536019004606 H-loop/switch region; other site 536019004607 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 536019004608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019004609 HWE histidine kinase; Region: HWE_HK; pfam07536 536019004610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019004611 HWE histidine kinase; Region: HWE_HK; pfam07536 536019004612 two-component response regulator; Provisional; Region: PRK09191 536019004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004614 active site 536019004615 phosphorylation site [posttranslational modification] 536019004616 intermolecular recognition site; other site 536019004617 dimerization interface [polypeptide binding]; other site 536019004618 RNA polymerase sigma factor; Provisional; Region: PRK12547 536019004619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019004620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019004621 DNA binding residues [nucleotide binding] 536019004622 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004624 active site 536019004625 phosphorylation site [posttranslational modification] 536019004626 intermolecular recognition site; other site 536019004627 dimerization interface [polypeptide binding]; other site 536019004628 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 536019004629 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019004630 GAF domain; Region: GAF; pfam01590 536019004631 PAS fold; Region: PAS_3; pfam08447 536019004632 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 536019004633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019004634 HWE histidine kinase; Region: HWE_HK; pfam07536 536019004635 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 536019004636 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 536019004637 PRC-barrel domain; Region: PRC; pfam05239 536019004638 PRC-barrel domain; Region: PRC; pfam05239 536019004639 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 536019004640 Sulfatase; Region: Sulfatase; cl17466 536019004641 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 536019004642 Zn binding site [ion binding]; other site 536019004643 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 536019004644 Zn binding site [ion binding]; other site 536019004645 Predicted esterase [General function prediction only]; Region: COG0400 536019004646 putative hydrolase; Provisional; Region: PRK11460 536019004647 Predicted acetyltransferase [General function prediction only]; Region: COG2388 536019004648 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 536019004649 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 536019004650 active site 536019004651 dimer interface [polypeptide binding]; other site 536019004652 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019004653 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 536019004654 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019004655 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 536019004656 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 536019004657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019004658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019004659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019004660 S-adenosylmethionine binding site [chemical binding]; other site 536019004661 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 536019004662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019004663 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536019004664 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019004665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019004666 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019004667 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019004668 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 536019004669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019004670 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019004671 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019004672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019004673 Walker A/P-loop; other site 536019004674 ATP binding site [chemical binding]; other site 536019004675 Q-loop/lid; other site 536019004676 ABC transporter signature motif; other site 536019004677 Walker B; other site 536019004678 D-loop; other site 536019004679 H-loop/switch region; other site 536019004680 TOBE domain; Region: TOBE_2; pfam08402 536019004681 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019004682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004683 dimer interface [polypeptide binding]; other site 536019004684 conserved gate region; other site 536019004685 putative PBP binding loops; other site 536019004686 ABC-ATPase subunit interface; other site 536019004687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004688 dimer interface [polypeptide binding]; other site 536019004689 conserved gate region; other site 536019004690 putative PBP binding loops; other site 536019004691 ABC-ATPase subunit interface; other site 536019004692 hypothetical protein; Provisional; Region: PRK07036 536019004693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019004694 inhibitor-cofactor binding pocket; inhibition site 536019004695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019004696 catalytic residue [active] 536019004697 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 536019004698 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 536019004699 [2Fe-2S] cluster binding site [ion binding]; other site 536019004700 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 536019004701 alpha subunit interface [polypeptide binding]; other site 536019004702 active site 536019004703 substrate binding site [chemical binding]; other site 536019004704 Fe binding site [ion binding]; other site 536019004705 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019004706 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536019004707 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 536019004708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019004709 putative active site [active] 536019004710 heme pocket [chemical binding]; other site 536019004711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019004712 dimer interface [polypeptide binding]; other site 536019004713 phosphorylation site [posttranslational modification] 536019004714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019004715 ATP binding site [chemical binding]; other site 536019004716 Mg2+ binding site [ion binding]; other site 536019004717 G-X-G motif; other site 536019004718 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004720 active site 536019004721 phosphorylation site [posttranslational modification] 536019004722 intermolecular recognition site; other site 536019004723 dimerization interface [polypeptide binding]; other site 536019004724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019004725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019004726 active site 536019004727 phosphorylation site [posttranslational modification] 536019004728 intermolecular recognition site; other site 536019004729 dimerization interface [polypeptide binding]; other site 536019004730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019004731 DNA binding site [nucleotide binding] 536019004732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019004733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019004734 DNA binding site [nucleotide binding] 536019004735 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019004736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019004737 multidrug efflux protein; Reviewed; Region: PRK09579 536019004738 Protein export membrane protein; Region: SecD_SecF; cl14618 536019004739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019004740 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019004741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019004742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019004743 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019004744 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019004745 Walker A/P-loop; other site 536019004746 ATP binding site [chemical binding]; other site 536019004747 Q-loop/lid; other site 536019004748 ABC transporter signature motif; other site 536019004749 Walker B; other site 536019004750 D-loop; other site 536019004751 H-loop/switch region; other site 536019004752 TOBE domain; Region: TOBE_2; pfam08402 536019004753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019004754 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 536019004755 substrate binding site [chemical binding]; other site 536019004756 ATP binding site [chemical binding]; other site 536019004757 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 536019004758 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 536019004759 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536019004760 dimer interface [polypeptide binding]; other site 536019004761 active site 536019004762 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019004763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004764 dimer interface [polypeptide binding]; other site 536019004765 conserved gate region; other site 536019004766 putative PBP binding loops; other site 536019004767 ABC-ATPase subunit interface; other site 536019004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004769 dimer interface [polypeptide binding]; other site 536019004770 conserved gate region; other site 536019004771 putative PBP binding loops; other site 536019004772 ABC-ATPase subunit interface; other site 536019004773 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019004774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019004775 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019004776 non-specific DNA interactions [nucleotide binding]; other site 536019004777 DNA binding site [nucleotide binding] 536019004778 sequence specific DNA binding site [nucleotide binding]; other site 536019004779 putative cAMP binding site [chemical binding]; other site 536019004780 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019004781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019004782 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536019004783 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536019004784 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 536019004785 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 536019004786 active site 536019004787 nucleophile elbow; other site 536019004788 Patatin phospholipase; Region: DUF3734; pfam12536 536019004789 acetoacetate decarboxylase; Provisional; Region: PRK02265 536019004790 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 536019004791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019004792 NAD(P) binding site [chemical binding]; other site 536019004793 active site 536019004794 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 536019004795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019004796 active site 536019004797 metal binding site [ion binding]; metal-binding site 536019004798 hexamer interface [polypeptide binding]; other site 536019004799 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 536019004800 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 536019004801 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 536019004802 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 536019004803 tetramer interface [polypeptide binding]; other site 536019004804 TPP-binding site [chemical binding]; other site 536019004805 heterodimer interface [polypeptide binding]; other site 536019004806 phosphorylation loop region [posttranslational modification] 536019004807 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 536019004808 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 536019004809 alpha subunit interface [polypeptide binding]; other site 536019004810 TPP binding site [chemical binding]; other site 536019004811 heterodimer interface [polypeptide binding]; other site 536019004812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019004813 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 536019004814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019004815 E3 interaction surface; other site 536019004816 lipoyl attachment site [posttranslational modification]; other site 536019004817 e3 binding domain; Region: E3_binding; pfam02817 536019004818 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536019004819 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019004820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 536019004821 DNA binding residues [nucleotide binding] 536019004822 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019004823 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019004824 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019004825 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 536019004826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004827 dimer interface [polypeptide binding]; other site 536019004828 conserved gate region; other site 536019004829 putative PBP binding loops; other site 536019004830 ABC-ATPase subunit interface; other site 536019004831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004832 dimer interface [polypeptide binding]; other site 536019004833 conserved gate region; other site 536019004834 putative PBP binding loops; other site 536019004835 ABC-ATPase subunit interface; other site 536019004836 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019004837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019004838 Walker A/P-loop; other site 536019004839 ATP binding site [chemical binding]; other site 536019004840 Q-loop/lid; other site 536019004841 ABC transporter signature motif; other site 536019004842 Walker B; other site 536019004843 D-loop; other site 536019004844 H-loop/switch region; other site 536019004845 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 536019004846 Survival protein SurE; Region: SurE; cl00448 536019004847 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 536019004848 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019004849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019004850 motif II; other site 536019004851 Glucitol operon activator protein (GutM); Region: GutM; cl01890 536019004852 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 536019004853 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 536019004854 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 536019004855 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 536019004856 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 536019004857 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536019004858 dimerization domain swap beta strand [polypeptide binding]; other site 536019004859 regulatory protein interface [polypeptide binding]; other site 536019004860 active site 536019004861 regulatory phosphorylation site [posttranslational modification]; other site 536019004862 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 536019004863 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536019004864 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536019004865 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536019004866 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019004867 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019004868 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 536019004869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019004870 active site 536019004871 motif I; other site 536019004872 motif II; other site 536019004873 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 536019004874 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536019004875 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019004876 nucleotide binding site [chemical binding]; other site 536019004877 Uncharacterized conserved protein [Function unknown]; Region: COG3347 536019004878 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 536019004879 intersubunit interface [polypeptide binding]; other site 536019004880 active site 536019004881 Zn2+ binding site [ion binding]; other site 536019004882 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019004883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019004884 putative DNA binding site [nucleotide binding]; other site 536019004885 putative Zn2+ binding site [ion binding]; other site 536019004886 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019004887 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536019004888 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 536019004889 N- and C-terminal domain interface [polypeptide binding]; other site 536019004890 putative active site [active] 536019004891 putative MgATP binding site [chemical binding]; other site 536019004892 putative catalytic site [active] 536019004893 metal binding site [ion binding]; metal-binding site 536019004894 putative carbohydrate binding site [chemical binding]; other site 536019004895 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019004896 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019004897 Walker A/P-loop; other site 536019004898 ATP binding site [chemical binding]; other site 536019004899 Q-loop/lid; other site 536019004900 ABC transporter signature motif; other site 536019004901 Walker B; other site 536019004902 D-loop; other site 536019004903 H-loop/switch region; other site 536019004904 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019004905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019004906 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019004907 TM-ABC transporter signature motif; other site 536019004908 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 536019004909 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019004910 putative ligand binding site [chemical binding]; other site 536019004911 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019004912 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019004913 Predicted membrane protein [Function unknown]; Region: COG4244 536019004914 Predicted transcriptional regulator [Transcription]; Region: COG4189 536019004915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019004916 dimerization interface [polypeptide binding]; other site 536019004917 putative DNA binding site [nucleotide binding]; other site 536019004918 putative Zn2+ binding site [ion binding]; other site 536019004919 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 536019004920 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 536019004921 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019004922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019004923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004924 dimer interface [polypeptide binding]; other site 536019004925 conserved gate region; other site 536019004926 putative PBP binding loops; other site 536019004927 ABC-ATPase subunit interface; other site 536019004928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019004930 dimer interface [polypeptide binding]; other site 536019004931 conserved gate region; other site 536019004932 putative PBP binding loops; other site 536019004933 ABC-ATPase subunit interface; other site 536019004934 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019004935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019004936 Walker A/P-loop; other site 536019004937 ATP binding site [chemical binding]; other site 536019004938 Q-loop/lid; other site 536019004939 ABC transporter signature motif; other site 536019004940 Walker B; other site 536019004941 D-loop; other site 536019004942 H-loop/switch region; other site 536019004943 TOBE domain; Region: TOBE_2; pfam08402 536019004944 AAA domain; Region: AAA_21; pfam13304 536019004945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 536019004946 ABC transporter signature motif; other site 536019004947 Walker B; other site 536019004948 D-loop; other site 536019004949 H-loop/switch region; other site 536019004950 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 536019004951 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 536019004952 metal binding site [ion binding]; metal-binding site 536019004953 putative dimer interface [polypeptide binding]; other site 536019004954 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 536019004955 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536019004956 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 536019004957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019004958 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 536019004959 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 536019004960 CPxP motif; other site 536019004961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 536019004962 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 536019004963 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 536019004964 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 536019004965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536019004966 active site 536019004967 DNA binding site [nucleotide binding] 536019004968 Int/Topo IB signature motif; other site 536019004969 shikimate kinase; Provisional; Region: PRK13946 536019004970 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 536019004971 ADP binding site [chemical binding]; other site 536019004972 magnesium binding site [ion binding]; other site 536019004973 putative shikimate binding site; other site 536019004974 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 536019004975 active site 536019004976 dimer interface [polypeptide binding]; other site 536019004977 metal binding site [ion binding]; metal-binding site 536019004978 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 536019004979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536019004980 Transporter associated domain; Region: CorC_HlyC; smart01091 536019004981 SpoVR family protein; Provisional; Region: PRK11767 536019004982 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 536019004983 Uncharacterized conserved protein [Function unknown]; Region: COG2718 536019004984 PrkA family serine protein kinase; Provisional; Region: PRK15455 536019004985 AAA ATPase domain; Region: AAA_16; pfam13191 536019004986 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 536019004987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 536019004988 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019004989 hypothetical protein; Validated; Region: PRK07586 536019004990 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019004991 PYR/PP interface [polypeptide binding]; other site 536019004992 dimer interface [polypeptide binding]; other site 536019004993 TPP binding site [chemical binding]; other site 536019004994 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 536019004995 TPP-binding site [chemical binding]; other site 536019004996 dimer interface [polypeptide binding]; other site 536019004997 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 536019004998 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 536019004999 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019005000 HSP70 interaction site [polypeptide binding]; other site 536019005001 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 536019005002 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 536019005003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 536019005004 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 536019005005 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 536019005006 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 536019005007 metal ion-dependent adhesion site (MIDAS); other site 536019005008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 536019005009 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 536019005010 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 536019005011 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 536019005012 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 536019005013 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 536019005014 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019005015 EamA-like transporter family; Region: EamA; pfam00892 536019005016 Predicted membrane protein [Function unknown]; Region: COG3714 536019005017 Uncharacterized conserved protein [Function unknown]; Region: COG3542 536019005018 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 536019005019 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019005020 Methyltransferase domain; Region: Methyltransf_11; pfam08241 536019005021 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 536019005022 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 536019005023 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 536019005024 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 536019005025 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 536019005026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019005027 active site 536019005028 Uncharacterized conserved protein [Function unknown]; Region: COG5470 536019005029 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019005030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019005031 S-adenosylmethionine binding site [chemical binding]; other site 536019005032 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 536019005033 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 536019005034 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 536019005035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019005036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019005037 homodimer interface [polypeptide binding]; other site 536019005038 catalytic residue [active] 536019005039 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 536019005040 prephenate dehydrogenase; Validated; Region: PRK08507 536019005041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019005042 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 536019005043 substrate binding site [chemical binding]; other site 536019005044 ATP binding site [chemical binding]; other site 536019005045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 536019005046 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 536019005047 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 536019005048 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536019005049 putative active site pocket [active] 536019005050 dimerization interface [polypeptide binding]; other site 536019005051 putative catalytic residue [active] 536019005052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019005053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019005054 active site 536019005055 catalytic tetrad [active] 536019005056 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019005057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 536019005058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 536019005059 putative acyl-acceptor binding pocket; other site 536019005060 transcriptional regulator; Provisional; Region: PRK10632 536019005061 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 536019005062 putative effector binding pocket; other site 536019005063 putative dimerization interface [polypeptide binding]; other site 536019005064 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 536019005065 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 536019005066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 536019005067 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019005068 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 536019005069 Uncharacterized conserved protein [Function unknown]; Region: COG1434 536019005070 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536019005071 putative active site [active] 536019005072 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 536019005073 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 536019005074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536019005075 Walker A/P-loop; other site 536019005076 ATP binding site [chemical binding]; other site 536019005077 Q-loop/lid; other site 536019005078 ABC transporter signature motif; other site 536019005079 Walker B; other site 536019005080 D-loop; other site 536019005081 H-loop/switch region; other site 536019005082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019005083 active site 536019005084 Response regulator receiver domain; Region: Response_reg; pfam00072 536019005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019005086 active site 536019005087 phosphorylation site [posttranslational modification] 536019005088 intermolecular recognition site; other site 536019005089 dimerization interface [polypeptide binding]; other site 536019005090 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019005091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019005092 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019005093 dimerization interface [polypeptide binding]; other site 536019005094 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 536019005095 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536019005096 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536019005097 tetramer interface [polypeptide binding]; other site 536019005098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019005099 catalytic residue [active] 536019005100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019005101 dimerization interface [polypeptide binding]; other site 536019005102 putative DNA binding site [nucleotide binding]; other site 536019005103 putative Zn2+ binding site [ion binding]; other site 536019005104 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 536019005105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 536019005106 active site 536019005107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019005108 substrate binding site [chemical binding]; other site 536019005109 catalytic residues [active] 536019005110 dimer interface [polypeptide binding]; other site 536019005111 argininosuccinate lyase; Provisional; Region: PRK00855 536019005112 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 536019005113 active sites [active] 536019005114 tetramer interface [polypeptide binding]; other site 536019005115 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 536019005116 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536019005117 catalytic residues [active] 536019005118 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 536019005119 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 536019005120 PAS domain S-box; Region: sensory_box; TIGR00229 536019005121 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019005122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019005123 metal binding site [ion binding]; metal-binding site 536019005124 active site 536019005125 I-site; other site 536019005126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019005127 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 536019005128 putative catalytic site [active] 536019005129 putative metal binding site [ion binding]; other site 536019005130 putative phosphate binding site [ion binding]; other site 536019005131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019005132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019005133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005134 dimer interface [polypeptide binding]; other site 536019005135 conserved gate region; other site 536019005136 putative PBP binding loops; other site 536019005137 ABC-ATPase subunit interface; other site 536019005138 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019005139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005140 dimer interface [polypeptide binding]; other site 536019005141 conserved gate region; other site 536019005142 putative PBP binding loops; other site 536019005143 ABC-ATPase subunit interface; other site 536019005144 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019005145 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019005146 Walker A/P-loop; other site 536019005147 ATP binding site [chemical binding]; other site 536019005148 Q-loop/lid; other site 536019005149 ABC transporter signature motif; other site 536019005150 Walker B; other site 536019005151 D-loop; other site 536019005152 H-loop/switch region; other site 536019005153 TOBE domain; Region: TOBE_2; pfam08402 536019005154 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 536019005155 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019005156 active site 536019005157 metal binding site [ion binding]; metal-binding site 536019005158 hexamer interface [polypeptide binding]; other site 536019005159 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019005160 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 536019005161 Walker A/P-loop; other site 536019005162 ATP binding site [chemical binding]; other site 536019005163 Q-loop/lid; other site 536019005164 ABC transporter signature motif; other site 536019005165 Walker B; other site 536019005166 D-loop; other site 536019005167 H-loop/switch region; other site 536019005168 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 536019005169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005170 dimer interface [polypeptide binding]; other site 536019005171 conserved gate region; other site 536019005172 putative PBP binding loops; other site 536019005173 ABC-ATPase subunit interface; other site 536019005174 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019005175 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536019005176 RNA polymerase sigma factor; Provisional; Region: PRK12512 536019005177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019005178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019005179 DNA binding residues [nucleotide binding] 536019005180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 536019005181 PAS domain S-box; Region: sensory_box; TIGR00229 536019005182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019005183 putative active site [active] 536019005184 heme pocket [chemical binding]; other site 536019005185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019005186 PAS fold; Region: PAS_3; pfam08447 536019005187 putative active site [active] 536019005188 heme pocket [chemical binding]; other site 536019005189 PAS fold; Region: PAS; pfam00989 536019005190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019005191 putative active site [active] 536019005192 heme pocket [chemical binding]; other site 536019005193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019005194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019005195 metal binding site [ion binding]; metal-binding site 536019005196 active site 536019005197 I-site; other site 536019005198 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 536019005199 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019005200 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019005201 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 536019005202 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 536019005203 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 536019005204 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 536019005205 Ligand binding site [chemical binding]; other site 536019005206 Electron transfer flavoprotein domain; Region: ETF; pfam01012 536019005207 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 536019005208 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 536019005209 short chain dehydrogenase; Provisional; Region: PRK05993 536019005210 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536019005211 NADP binding site [chemical binding]; other site 536019005212 active site 536019005213 steroid binding site; other site 536019005214 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 536019005215 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019005216 EamA-like transporter family; Region: EamA; pfam00892 536019005217 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 536019005218 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 536019005219 active site 536019005220 HIGH motif; other site 536019005221 nucleotide binding site [chemical binding]; other site 536019005222 active site 536019005223 KMSKS motif; other site 536019005224 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536019005225 endonuclease III; Region: ENDO3c; smart00478 536019005226 minor groove reading motif; other site 536019005227 helix-hairpin-helix signature motif; other site 536019005228 substrate binding pocket [chemical binding]; other site 536019005229 active site 536019005230 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 536019005231 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 536019005232 active site 536019005233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019005234 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019005235 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019005236 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 536019005237 Predicted membrane protein [Function unknown]; Region: COG1238 536019005238 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019005239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019005240 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536019005241 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 536019005242 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 536019005243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 536019005244 ATP binding site [chemical binding]; other site 536019005245 putative Mg++ binding site [ion binding]; other site 536019005246 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 536019005247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 536019005248 nucleotide binding region [chemical binding]; other site 536019005249 ATP-binding site [chemical binding]; other site 536019005250 SEC-C motif; Region: SEC-C; pfam02810 536019005251 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 536019005252 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 536019005253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019005254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019005255 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019005256 Caspase domain; Region: Peptidase_C14; pfam00656 536019005257 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 536019005258 heterotetramer interface [polypeptide binding]; other site 536019005259 active site pocket [active] 536019005260 cleavage site 536019005261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019005262 Coenzyme A binding pocket [chemical binding]; other site 536019005263 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 536019005264 active site 536019005265 8-oxo-dGMP binding site [chemical binding]; other site 536019005266 nudix motif; other site 536019005267 metal binding site [ion binding]; metal-binding site 536019005268 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 536019005269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019005270 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 536019005271 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 536019005272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019005273 active site 536019005274 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 536019005275 GSH binding site [chemical binding]; other site 536019005276 catalytic residues [active] 536019005277 Predicted amidohydrolase [General function prediction only]; Region: COG0388 536019005278 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 536019005279 putative active site [active] 536019005280 catalytic triad [active] 536019005281 dimer interface [polypeptide binding]; other site 536019005282 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 536019005283 MarR family; Region: MarR_2; cl17246 536019005284 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019005285 EamA-like transporter family; Region: EamA; pfam00892 536019005286 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 536019005287 Methyltransferase domain; Region: Methyltransf_11; pfam08241 536019005288 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 536019005289 CHASE3 domain; Region: CHASE3; pfam05227 536019005290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019005291 dimer interface [polypeptide binding]; other site 536019005292 phosphorylation site [posttranslational modification] 536019005293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019005294 ATP binding site [chemical binding]; other site 536019005295 Mg2+ binding site [ion binding]; other site 536019005296 G-X-G motif; other site 536019005297 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019005298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019005299 active site 536019005300 phosphorylation site [posttranslational modification] 536019005301 intermolecular recognition site; other site 536019005302 dimerization interface [polypeptide binding]; other site 536019005303 aspartate kinase; Reviewed; Region: PRK06635 536019005304 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 536019005305 putative nucleotide binding site [chemical binding]; other site 536019005306 putative catalytic residues [active] 536019005307 putative Mg ion binding site [ion binding]; other site 536019005308 putative aspartate binding site [chemical binding]; other site 536019005309 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 536019005310 putative allosteric regulatory site; other site 536019005311 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 536019005312 putative allosteric regulatory residue; other site 536019005313 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 536019005314 GAF domain; Region: GAF; pfam01590 536019005315 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536019005316 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536019005317 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536019005318 peptide chain release factor 1; Validated; Region: prfA; PRK00591 536019005319 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 536019005320 This domain is found in peptide chain release factors; Region: PCRF; smart00937 536019005321 RF-1 domain; Region: RF-1; pfam00472 536019005322 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 536019005323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019005324 S-adenosylmethionine binding site [chemical binding]; other site 536019005325 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 536019005326 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 536019005327 Clp amino terminal domain; Region: Clp_N; pfam02861 536019005328 Clp amino terminal domain; Region: Clp_N; pfam02861 536019005329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019005330 Walker A motif; other site 536019005331 ATP binding site [chemical binding]; other site 536019005332 Walker B motif; other site 536019005333 arginine finger; other site 536019005334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019005335 Walker A motif; other site 536019005336 ATP binding site [chemical binding]; other site 536019005337 Walker B motif; other site 536019005338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 536019005339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 536019005340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019005341 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019005342 Predicted integral membrane protein [Function unknown]; Region: COG3548 536019005343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019005344 putative substrate translocation pore; other site 536019005345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019005346 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 536019005347 Peptidase family M23; Region: Peptidase_M23; pfam01551 536019005348 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 536019005349 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 536019005350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019005351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019005352 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019005353 putative effector binding pocket; other site 536019005354 dimerization interface [polypeptide binding]; other site 536019005355 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 536019005356 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 536019005357 catalytic residues [active] 536019005358 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 536019005359 NADH(P)-binding; Region: NAD_binding_10; pfam13460 536019005360 NAD binding site [chemical binding]; other site 536019005361 substrate binding site [chemical binding]; other site 536019005362 putative active site [active] 536019005363 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019005364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536019005365 nucleotide binding site [chemical binding]; other site 536019005366 AAA domain; Region: AAA_33; pfam13671 536019005367 AAA domain; Region: AAA_17; pfam13207 536019005368 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 536019005369 catalytic residue [active] 536019005370 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019005371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019005372 DNA binding residues [nucleotide binding] 536019005373 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019005374 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 536019005375 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019005376 putative ligand binding site [chemical binding]; other site 536019005377 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019005378 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019005379 TM-ABC transporter signature motif; other site 536019005380 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019005381 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019005382 Walker A/P-loop; other site 536019005383 ATP binding site [chemical binding]; other site 536019005384 Q-loop/lid; other site 536019005385 ABC transporter signature motif; other site 536019005386 Walker B; other site 536019005387 D-loop; other site 536019005388 H-loop/switch region; other site 536019005389 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 536019005390 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536019005391 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019005392 Walker A/P-loop; other site 536019005393 ATP binding site [chemical binding]; other site 536019005394 Q-loop/lid; other site 536019005395 ABC transporter signature motif; other site 536019005396 Walker B; other site 536019005397 D-loop; other site 536019005398 H-loop/switch region; other site 536019005399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 536019005400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019005401 Walker A/P-loop; other site 536019005402 ATP binding site [chemical binding]; other site 536019005403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019005404 Q-loop/lid; other site 536019005405 ABC transporter signature motif; other site 536019005406 Walker B; other site 536019005407 D-loop; other site 536019005408 H-loop/switch region; other site 536019005409 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019005410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005411 dimer interface [polypeptide binding]; other site 536019005412 conserved gate region; other site 536019005413 putative PBP binding loops; other site 536019005414 ABC-ATPase subunit interface; other site 536019005415 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005417 dimer interface [polypeptide binding]; other site 536019005418 conserved gate region; other site 536019005419 putative PBP binding loops; other site 536019005420 ABC-ATPase subunit interface; other site 536019005421 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019005422 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 536019005423 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019005424 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019005425 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019005426 active site 536019005427 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 536019005428 Cupin domain; Region: Cupin_2; pfam07883 536019005429 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 536019005430 Uncharacterized conserved protein [Function unknown]; Region: COG5441 536019005431 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 536019005432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019005433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019005434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019005435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019005436 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 536019005437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005438 conserved gate region; other site 536019005439 dimer interface [polypeptide binding]; other site 536019005440 putative PBP binding loops; other site 536019005441 ABC-ATPase subunit interface; other site 536019005442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005444 dimer interface [polypeptide binding]; other site 536019005445 conserved gate region; other site 536019005446 putative PBP binding loops; other site 536019005447 ABC-ATPase subunit interface; other site 536019005448 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019005449 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019005450 Walker A/P-loop; other site 536019005451 ATP binding site [chemical binding]; other site 536019005452 Q-loop/lid; other site 536019005453 ABC transporter signature motif; other site 536019005454 Walker B; other site 536019005455 D-loop; other site 536019005456 H-loop/switch region; other site 536019005457 TOBE domain; Region: TOBE; pfam03459 536019005458 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019005459 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019005460 Walker A/P-loop; other site 536019005461 ATP binding site [chemical binding]; other site 536019005462 Q-loop/lid; other site 536019005463 ABC transporter signature motif; other site 536019005464 Walker B; other site 536019005465 D-loop; other site 536019005466 H-loop/switch region; other site 536019005467 TOBE domain; Region: TOBE_2; pfam08402 536019005468 Cupin; Region: Cupin_6; pfam12852 536019005469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019005470 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019005471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019005472 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019005473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019005474 putative substrate translocation pore; other site 536019005475 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019005476 amidase; Validated; Region: PRK05962 536019005477 amidase; Provisional; Region: PRK07056 536019005478 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019005479 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 536019005480 ligand binding site [chemical binding]; other site 536019005481 NAD binding site [chemical binding]; other site 536019005482 dimerization interface [polypeptide binding]; other site 536019005483 catalytic site [active] 536019005484 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019005485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019005486 DNA-binding site [nucleotide binding]; DNA binding site 536019005487 FCD domain; Region: FCD; pfam07729 536019005488 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019005489 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019005490 active site pocket [active] 536019005491 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019005492 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536019005493 DNA interaction; other site 536019005494 Metal-binding active site; metal-binding site 536019005495 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019005496 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536019005497 AP (apurinic/apyrimidinic) site pocket; other site 536019005498 DNA interaction; other site 536019005499 Metal-binding active site; metal-binding site 536019005500 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 536019005501 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019005502 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019005503 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019005504 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019005505 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536019005506 DNA interaction; other site 536019005507 Metal-binding active site; metal-binding site 536019005508 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 536019005509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005510 dimer interface [polypeptide binding]; other site 536019005511 conserved gate region; other site 536019005512 putative PBP binding loops; other site 536019005513 ABC-ATPase subunit interface; other site 536019005514 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 536019005515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005516 dimer interface [polypeptide binding]; other site 536019005517 conserved gate region; other site 536019005518 ABC-ATPase subunit interface; other site 536019005519 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 536019005520 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 536019005521 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 536019005522 Walker A/P-loop; other site 536019005523 ATP binding site [chemical binding]; other site 536019005524 Q-loop/lid; other site 536019005525 ABC transporter signature motif; other site 536019005526 Walker B; other site 536019005527 D-loop; other site 536019005528 H-loop/switch region; other site 536019005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 536019005530 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 536019005531 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 536019005532 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 536019005533 trimer interface [polypeptide binding]; other site 536019005534 active site 536019005535 substrate binding site [chemical binding]; other site 536019005536 CoA binding site [chemical binding]; other site 536019005537 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 536019005538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019005539 Walker A/P-loop; other site 536019005540 ATP binding site [chemical binding]; other site 536019005541 Q-loop/lid; other site 536019005542 ABC transporter signature motif; other site 536019005543 Walker B; other site 536019005544 D-loop; other site 536019005545 H-loop/switch region; other site 536019005546 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 536019005547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019005548 Walker A/P-loop; other site 536019005549 ATP binding site [chemical binding]; other site 536019005550 Q-loop/lid; other site 536019005551 ABC transporter signature motif; other site 536019005552 Walker B; other site 536019005553 D-loop; other site 536019005554 H-loop/switch region; other site 536019005555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019005556 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 536019005557 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 536019005558 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 536019005559 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 536019005560 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 536019005561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019005562 DNA-binding site [nucleotide binding]; DNA binding site 536019005563 UTRA domain; Region: UTRA; pfam07702 536019005564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536019005565 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 536019005566 putative NAD(P) binding site [chemical binding]; other site 536019005567 catalytic Zn binding site [ion binding]; other site 536019005568 structural Zn binding site [ion binding]; other site 536019005569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019005570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019005571 TM-ABC transporter signature motif; other site 536019005572 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019005573 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019005574 Walker A/P-loop; other site 536019005575 ATP binding site [chemical binding]; other site 536019005576 Q-loop/lid; other site 536019005577 ABC transporter signature motif; other site 536019005578 Walker B; other site 536019005579 D-loop; other site 536019005580 H-loop/switch region; other site 536019005581 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019005582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019005583 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 536019005584 putative ligand binding site [chemical binding]; other site 536019005585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019005586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019005587 active site 536019005588 catalytic tetrad [active] 536019005589 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 536019005590 galactarate dehydratase; Region: galactar-dH20; TIGR03248 536019005591 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 536019005592 Winged helix-turn helix; Region: HTH_29; pfam13551 536019005593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019005594 DNA-binding site [nucleotide binding]; DNA binding site 536019005595 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019005596 FCD domain; Region: FCD; pfam07729 536019005597 Protein of unknown function (DUF461); Region: DUF461; pfam04314 536019005598 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 536019005599 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 536019005600 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 536019005601 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 536019005602 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019005603 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 536019005604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019005605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019005606 DNA binding site [nucleotide binding] 536019005607 domain linker motif; other site 536019005608 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 536019005609 ligand binding site [chemical binding]; other site 536019005610 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019005611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019005612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005613 dimer interface [polypeptide binding]; other site 536019005614 conserved gate region; other site 536019005615 putative PBP binding loops; other site 536019005616 ABC-ATPase subunit interface; other site 536019005617 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005619 dimer interface [polypeptide binding]; other site 536019005620 conserved gate region; other site 536019005621 putative PBP binding loops; other site 536019005622 ABC-ATPase subunit interface; other site 536019005623 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019005624 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019005625 Walker A/P-loop; other site 536019005626 ATP binding site [chemical binding]; other site 536019005627 Q-loop/lid; other site 536019005628 ABC transporter signature motif; other site 536019005629 Walker B; other site 536019005630 D-loop; other site 536019005631 H-loop/switch region; other site 536019005632 TOBE domain; Region: TOBE_2; pfam08402 536019005633 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019005634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019005635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019005636 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019005637 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019005638 active site 536019005639 catalytic tetrad [active] 536019005640 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 536019005641 cleavage site 536019005642 active site 536019005643 substrate binding sites [chemical binding]; other site 536019005644 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 536019005645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 536019005646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 536019005647 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 536019005648 putative ligand binding pocket/active site [active] 536019005649 putative metal binding site [ion binding]; other site 536019005650 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 536019005651 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 536019005652 putative active site [active] 536019005653 putative metal binding site [ion binding]; other site 536019005654 FOG: WD40 repeat [General function prediction only]; Region: COG2319 536019005655 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 536019005656 structural tetrad; other site 536019005657 FOG: WD40 repeat [General function prediction only]; Region: COG2319 536019005658 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 536019005659 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019005660 Caspase domain; Region: Peptidase_C14; pfam00656 536019005661 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 536019005662 Caspase domain; Region: Peptidase_C14; pfam00656 536019005663 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 536019005664 metal binding site 2 [ion binding]; metal-binding site 536019005665 putative DNA binding helix; other site 536019005666 metal binding site 1 [ion binding]; metal-binding site 536019005667 dimer interface [polypeptide binding]; other site 536019005668 structural Zn2+ binding site [ion binding]; other site 536019005669 5'-3' exonuclease; Region: 53EXOc; smart00475 536019005670 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 536019005671 active site 536019005672 metal binding site 1 [ion binding]; metal-binding site 536019005673 putative 5' ssDNA interaction site; other site 536019005674 metal binding site 3; metal-binding site 536019005675 metal binding site 2 [ion binding]; metal-binding site 536019005676 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 536019005677 putative DNA binding site [nucleotide binding]; other site 536019005678 putative metal binding site [ion binding]; other site 536019005679 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 536019005680 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 536019005681 active site 536019005682 catalytic site [active] 536019005683 substrate binding site [chemical binding]; other site 536019005684 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 536019005685 active site 536019005686 DNA binding site [nucleotide binding] 536019005687 catalytic site [active] 536019005688 hypothetical protein; Validated; Region: PRK09104 536019005689 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 536019005690 metal binding site [ion binding]; metal-binding site 536019005691 putative dimer interface [polypeptide binding]; other site 536019005692 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 536019005693 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 536019005694 catalytic site [active] 536019005695 putative active site [active] 536019005696 putative substrate binding site [chemical binding]; other site 536019005697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536019005698 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 536019005699 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 536019005700 Transglycosylase; Region: Transgly; pfam00912 536019005701 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 536019005702 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019005703 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 536019005704 classical (c) SDRs; Region: SDR_c; cd05233 536019005705 NAD(P) binding site [chemical binding]; other site 536019005706 active site 536019005707 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 536019005708 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019005709 putative NAD(P) binding site [chemical binding]; other site 536019005710 Helix-turn-helix domain; Region: HTH_18; pfam12833 536019005711 putative cation:proton antiport protein; Provisional; Region: PRK10669 536019005712 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 536019005713 TrkA-N domain; Region: TrkA_N; pfam02254 536019005714 Protein required for attachment to host cells; Region: Host_attach; pfam10116 536019005715 siroheme synthase; Provisional; Region: cysG; PRK10637 536019005716 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 536019005717 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 536019005718 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 536019005719 active site 536019005720 SAM binding site [chemical binding]; other site 536019005721 homodimer interface [polypeptide binding]; other site 536019005722 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 536019005723 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 536019005724 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536019005725 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536019005726 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 536019005727 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536019005728 Active Sites [active] 536019005729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 536019005730 intracellular protease, PfpI family; Region: PfpI; TIGR01382 536019005731 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 536019005732 conserved cys residue [active] 536019005733 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 536019005734 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 536019005735 putative di-iron ligands [ion binding]; other site 536019005736 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019005737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019005738 DNA binding site [nucleotide binding] 536019005739 domain linker motif; other site 536019005740 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019005741 dimerization interface [polypeptide binding]; other site 536019005742 ligand binding site [chemical binding]; other site 536019005743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019005744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019005745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005746 dimer interface [polypeptide binding]; other site 536019005747 conserved gate region; other site 536019005748 putative PBP binding loops; other site 536019005749 ABC-ATPase subunit interface; other site 536019005750 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019005751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019005752 dimer interface [polypeptide binding]; other site 536019005753 conserved gate region; other site 536019005754 putative PBP binding loops; other site 536019005755 ABC-ATPase subunit interface; other site 536019005756 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 536019005757 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019005758 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019005759 Walker A/P-loop; other site 536019005760 ATP binding site [chemical binding]; other site 536019005761 Q-loop/lid; other site 536019005762 ABC transporter signature motif; other site 536019005763 Walker B; other site 536019005764 D-loop; other site 536019005765 H-loop/switch region; other site 536019005766 TOBE domain; Region: TOBE_2; pfam08402 536019005767 heat shock protein GrpE; Provisional; Region: PRK14141 536019005768 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 536019005769 dimer interface [polypeptide binding]; other site 536019005770 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 536019005771 Predicted membrane protein [Function unknown]; Region: COG2860 536019005772 UPF0126 domain; Region: UPF0126; pfam03458 536019005773 UPF0126 domain; Region: UPF0126; pfam03458 536019005774 Putative hemolysin [General function prediction only]; Region: COG3176 536019005775 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 536019005776 PAS domain; Region: PAS; smart00091 536019005777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019005778 dimer interface [polypeptide binding]; other site 536019005779 phosphorylation site [posttranslational modification] 536019005780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019005781 ATP binding site [chemical binding]; other site 536019005782 Mg2+ binding site [ion binding]; other site 536019005783 G-X-G motif; other site 536019005784 Response regulator receiver domain; Region: Response_reg; pfam00072 536019005785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019005786 active site 536019005787 phosphorylation site [posttranslational modification] 536019005788 intermolecular recognition site; other site 536019005789 dimerization interface [polypeptide binding]; other site 536019005790 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 536019005791 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 536019005792 NADP binding site [chemical binding]; other site 536019005793 dimer interface [polypeptide binding]; other site 536019005794 lipoprotein signal peptidase; Provisional; Region: PRK14795 536019005795 lipoprotein signal peptidase; Provisional; Region: PRK14787 536019005796 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 536019005797 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 536019005798 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536019005799 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 536019005800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019005801 S-adenosylmethionine binding site [chemical binding]; other site 536019005802 Predicted transcriptional regulator [Transcription]; Region: COG2378 536019005803 HTH domain; Region: HTH_11; pfam08279 536019005804 WYL domain; Region: WYL; pfam13280 536019005805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019005806 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 536019005807 putative dimer interface [polypeptide binding]; other site 536019005808 hypothetical protein; Provisional; Region: PRK02268 536019005809 ornithine cyclodeaminase; Validated; Region: PRK06141 536019005810 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 536019005811 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536019005812 IHF dimer interface [polypeptide binding]; other site 536019005813 IHF - DNA interface [nucleotide binding]; other site 536019005814 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 536019005815 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 536019005816 tandem repeat interface [polypeptide binding]; other site 536019005817 oligomer interface [polypeptide binding]; other site 536019005818 active site residues [active] 536019005819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 536019005820 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 536019005821 OstA-like protein; Region: OstA; pfam03968 536019005822 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 536019005823 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 536019005824 Walker A/P-loop; other site 536019005825 ATP binding site [chemical binding]; other site 536019005826 Q-loop/lid; other site 536019005827 ABC transporter signature motif; other site 536019005828 Walker B; other site 536019005829 D-loop; other site 536019005830 H-loop/switch region; other site 536019005831 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 536019005832 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 536019005833 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 536019005834 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 536019005835 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 536019005836 30S subunit binding site; other site 536019005837 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536019005838 active site 536019005839 phosphorylation site [posttranslational modification] 536019005840 Uncharacterized small protein [Function unknown]; Region: COG5568 536019005841 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019005842 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536019005843 putative dimer interface [polypeptide binding]; other site 536019005844 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536019005845 active site 536019005846 tetramer interface [polypeptide binding]; other site 536019005847 LysE type translocator; Region: LysE; cl00565 536019005848 amidase; Provisional; Region: PRK07486 536019005849 Amidase; Region: Amidase; pfam01425 536019005850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019005851 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 536019005852 substrate binding site [chemical binding]; other site 536019005853 dimer interface [polypeptide binding]; other site 536019005854 ATP binding site [chemical binding]; other site 536019005855 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536019005856 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 536019005857 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536019005858 DNA binding site [nucleotide binding] 536019005859 active site 536019005860 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 536019005861 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 536019005862 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 536019005863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 536019005864 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 536019005865 Integral membrane protein [Function unknown]; Region: COG5488 536019005866 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 536019005867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536019005868 minor groove reading motif; other site 536019005869 helix-hairpin-helix signature motif; other site 536019005870 substrate binding pocket [chemical binding]; other site 536019005871 active site 536019005872 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 536019005873 Predicted membrane protein [Function unknown]; Region: COG3556 536019005874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019005875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019005876 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 536019005877 nudix motif; other site 536019005878 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 536019005879 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 536019005880 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 536019005881 Flavoprotein; Region: Flavoprotein; pfam02441 536019005882 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 536019005883 ABC1 family; Region: ABC1; cl17513 536019005884 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 536019005885 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 536019005886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019005887 S-adenosylmethionine binding site [chemical binding]; other site 536019005888 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 536019005889 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 536019005890 active site 536019005891 purine riboside binding site [chemical binding]; other site 536019005892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019005893 active site 536019005894 Predicted aspartyl protease [General function prediction only]; Region: COG3577 536019005895 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 536019005896 catalytic motif [active] 536019005897 Catalytic residue [active] 536019005898 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 536019005899 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 536019005900 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 536019005901 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 536019005902 purine nucleoside phosphorylase; Provisional; Region: PRK08202 536019005903 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 536019005904 active site 536019005905 catalytic motif [active] 536019005906 Zn binding site [ion binding]; other site 536019005907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019005908 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019005909 TM-ABC transporter signature motif; other site 536019005910 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019005911 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019005912 TM-ABC transporter signature motif; other site 536019005913 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 536019005914 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019005915 Walker A/P-loop; other site 536019005916 ATP binding site [chemical binding]; other site 536019005917 Q-loop/lid; other site 536019005918 ABC transporter signature motif; other site 536019005919 Walker B; other site 536019005920 D-loop; other site 536019005921 H-loop/switch region; other site 536019005922 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019005923 hypothetical protein; Provisional; Region: PRK00736 536019005924 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 536019005925 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 536019005926 ligand binding site [chemical binding]; other site 536019005927 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 536019005928 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 536019005929 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536019005930 Soluble P-type ATPase [General function prediction only]; Region: COG4087 536019005931 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 536019005932 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 536019005933 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 536019005934 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 536019005935 Ligand Binding Site [chemical binding]; other site 536019005936 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 536019005937 GAF domain; Region: GAF_3; pfam13492 536019005938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019005939 dimer interface [polypeptide binding]; other site 536019005940 phosphorylation site [posttranslational modification] 536019005941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019005942 ATP binding site [chemical binding]; other site 536019005943 Mg2+ binding site [ion binding]; other site 536019005944 G-X-G motif; other site 536019005945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019005946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019005947 active site 536019005948 phosphorylation site [posttranslational modification] 536019005949 intermolecular recognition site; other site 536019005950 dimerization interface [polypeptide binding]; other site 536019005951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019005952 DNA binding site [nucleotide binding] 536019005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019005954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019005955 putative substrate translocation pore; other site 536019005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019005957 Protein of unknown function (DUF992); Region: DUF992; pfam06186 536019005958 Protein of unknown function (DUF992); Region: DUF992; pfam06186 536019005959 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 536019005960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019005961 TPR motif; other site 536019005962 binding surface 536019005963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019005964 binding surface 536019005965 TPR motif; other site 536019005966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019005967 binding surface 536019005968 TPR motif; other site 536019005969 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 536019005970 Proteins containing SET domain [General function prediction only]; Region: COG2940 536019005971 SET domain; Region: SET; pfam00856 536019005972 short chain dehydrogenase; Provisional; Region: PRK07478 536019005973 classical (c) SDRs; Region: SDR_c; cd05233 536019005974 NAD(P) binding site [chemical binding]; other site 536019005975 active site 536019005976 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 536019005977 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 536019005978 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019005979 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 536019005980 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 536019005981 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019005982 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019005983 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 536019005984 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 536019005985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019005986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019005987 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019005988 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019005989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019005990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019005991 WHG domain; Region: WHG; pfam13305 536019005992 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 536019005993 Phosphotransferase enzyme family; Region: APH; pfam01636 536019005994 putative active site [active] 536019005995 putative substrate binding site [chemical binding]; other site 536019005996 ATP binding site [chemical binding]; other site 536019005997 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 536019005998 putative active site [active] 536019005999 putative catalytic site [active] 536019006000 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 536019006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019006002 NAD(P) binding site [chemical binding]; other site 536019006003 active site 536019006004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019006005 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 536019006006 FAD binding site [chemical binding]; other site 536019006007 substrate binding site [chemical binding]; other site 536019006008 catalytic base [active] 536019006009 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019006010 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 536019006011 NADP binding site [chemical binding]; other site 536019006012 dimer interface [polypeptide binding]; other site 536019006013 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 536019006014 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 536019006015 Ligand binding site; other site 536019006016 Putative Catalytic site; other site 536019006017 DXD motif; other site 536019006018 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 536019006019 putative active site [active] 536019006020 YdjC motif; other site 536019006021 Mg binding site [ion binding]; other site 536019006022 putative homodimer interface [polypeptide binding]; other site 536019006023 Predicted membrane protein [Function unknown]; Region: COG2246 536019006024 GtrA-like protein; Region: GtrA; pfam04138 536019006025 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019006026 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019006027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019006028 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019006029 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019006030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019006031 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019006032 putative active site [active] 536019006033 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 536019006034 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 536019006035 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536019006036 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 536019006037 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019006038 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 536019006039 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 536019006040 NAD(P) binding site [chemical binding]; other site 536019006041 catalytic residues [active] 536019006042 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 536019006043 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 536019006044 putative active site [active] 536019006045 metal binding site [ion binding]; metal-binding site 536019006046 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019006047 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019006048 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 536019006049 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019006050 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019006051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006052 dimer interface [polypeptide binding]; other site 536019006053 conserved gate region; other site 536019006054 putative PBP binding loops; other site 536019006055 ABC-ATPase subunit interface; other site 536019006056 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019006057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019006058 Walker A/P-loop; other site 536019006059 ATP binding site [chemical binding]; other site 536019006060 Q-loop/lid; other site 536019006061 ABC transporter signature motif; other site 536019006062 Walker B; other site 536019006063 D-loop; other site 536019006064 H-loop/switch region; other site 536019006065 TOBE domain; Region: TOBE_2; pfam08402 536019006066 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 536019006067 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 536019006068 putative catalytic site [active] 536019006069 putative metal binding site [ion binding]; other site 536019006070 putative phosphate binding site [ion binding]; other site 536019006071 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 536019006072 putative sialic acid transporter; Region: 2A0112; TIGR00891 536019006073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019006074 putative substrate translocation pore; other site 536019006075 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 536019006076 choline dehydrogenase; Validated; Region: PRK02106 536019006077 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019006078 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 536019006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019006080 NAD(P) binding site [chemical binding]; other site 536019006081 active site 536019006082 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 536019006083 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019006084 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019006085 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019006086 Walker A/P-loop; other site 536019006087 ATP binding site [chemical binding]; other site 536019006088 Q-loop/lid; other site 536019006089 ABC transporter signature motif; other site 536019006090 Walker B; other site 536019006091 D-loop; other site 536019006092 H-loop/switch region; other site 536019006093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019006094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006095 dimer interface [polypeptide binding]; other site 536019006096 conserved gate region; other site 536019006097 putative PBP binding loops; other site 536019006098 ABC-ATPase subunit interface; other site 536019006099 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019006100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006101 putative PBP binding loops; other site 536019006102 dimer interface [polypeptide binding]; other site 536019006103 ABC-ATPase subunit interface; other site 536019006104 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019006105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019006106 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019006107 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 536019006108 NAD(P) binding site [chemical binding]; other site 536019006109 catalytic residues [active] 536019006110 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 536019006111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019006112 substrate binding site [chemical binding]; other site 536019006113 oxyanion hole (OAH) forming residues; other site 536019006114 trimer interface [polypeptide binding]; other site 536019006115 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 536019006116 Coenzyme A transferase; Region: CoA_trans; smart00882 536019006117 Coenzyme A transferase; Region: CoA_trans; cl17247 536019006118 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019006119 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019006120 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019006121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019006122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019006123 DNA binding site [nucleotide binding] 536019006124 domain linker motif; other site 536019006125 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 536019006126 putative dimerization interface [polypeptide binding]; other site 536019006127 putative ligand binding site [chemical binding]; other site 536019006128 Protein of unknown function (DUF993); Region: DUF993; pfam06187 536019006129 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 536019006130 Response regulator receiver domain; Region: Response_reg; pfam00072 536019006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006132 active site 536019006133 phosphorylation site [posttranslational modification] 536019006134 intermolecular recognition site; other site 536019006135 dimerization interface [polypeptide binding]; other site 536019006136 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 536019006137 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019006138 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 536019006139 active site 536019006140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019006141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019006142 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019006143 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 536019006144 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019006145 Serine hydrolase; Region: Ser_hydrolase; cl17834 536019006146 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019006147 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536019006148 putative dimer interface [polypeptide binding]; other site 536019006149 Uncharacterized secreted protein [Function unknown]; Region: COG5430 536019006150 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 536019006151 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536019006152 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 536019006153 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536019006154 Spore Coat Protein U domain; Region: SCPU; pfam05229 536019006155 Uncharacterized secreted protein [Function unknown]; Region: COG5430 536019006156 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 536019006157 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 536019006158 tetramer interface [polypeptide binding]; other site 536019006159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019006160 catalytic residue [active] 536019006161 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 536019006162 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 536019006163 active site 536019006164 dimer interface [polypeptide binding]; other site 536019006165 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 536019006166 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 536019006167 active site 536019006168 FMN binding site [chemical binding]; other site 536019006169 substrate binding site [chemical binding]; other site 536019006170 3Fe-4S cluster binding site [ion binding]; other site 536019006171 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 536019006172 domain interface; other site 536019006173 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 536019006174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019006175 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 536019006176 active site 536019006177 catalytic triad [active] 536019006178 oxyanion hole [active] 536019006179 Transglycosylase SLT domain; Region: SLT_2; pfam13406 536019006180 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019006181 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019006182 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019006183 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 536019006184 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 536019006185 active site 536019006186 tetramer interface; other site 536019006187 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 536019006188 KpsF/GutQ family protein; Region: kpsF; TIGR00393 536019006189 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 536019006190 putative active site [active] 536019006191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 536019006192 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 536019006193 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 536019006194 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 536019006195 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019006196 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019006197 ferrochelatase; Reviewed; Region: hemH; PRK00035 536019006198 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 536019006199 C-terminal domain interface [polypeptide binding]; other site 536019006200 active site 536019006201 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 536019006202 active site 536019006203 N-terminal domain interface [polypeptide binding]; other site 536019006204 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 536019006205 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 536019006206 active site 536019006207 metal binding site [ion binding]; metal-binding site 536019006208 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 536019006209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536019006210 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 536019006211 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 536019006212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019006213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019006214 NAD(P) binding site [chemical binding]; other site 536019006215 active site 536019006216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019006217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019006218 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019006219 putative effector binding pocket; other site 536019006220 dimerization interface [polypeptide binding]; other site 536019006221 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 536019006222 hypothetical protein; Provisional; Region: PRK07546 536019006223 substrate-cofactor binding pocket; other site 536019006224 homodimer interface [polypeptide binding]; other site 536019006225 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536019006226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019006227 catalytic residue [active] 536019006228 aminodeoxychorismate synthase; Provisional; Region: PRK07508 536019006229 chorismate binding enzyme; Region: Chorismate_bind; cl10555 536019006230 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 536019006231 Uncharacterized conserved protein [Function unknown]; Region: COG3743 536019006232 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 536019006233 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 536019006234 active site 536019006235 Zn binding site [ion binding]; other site 536019006236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 536019006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006238 active site 536019006239 phosphorylation site [posttranslational modification] 536019006240 intermolecular recognition site; other site 536019006241 dimerization interface [polypeptide binding]; other site 536019006242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019006243 Walker A motif; other site 536019006244 ATP binding site [chemical binding]; other site 536019006245 Walker B motif; other site 536019006246 arginine finger; other site 536019006247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019006248 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 536019006249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 536019006250 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 536019006251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019006252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019006253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019006254 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 536019006255 NAD(P) binding site [chemical binding]; other site 536019006256 active site 536019006257 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 536019006258 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 536019006259 active site 536019006260 intersubunit interface [polypeptide binding]; other site 536019006261 catalytic residue [active] 536019006262 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 536019006263 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 536019006264 active site residue [active] 536019006265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 536019006266 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 536019006267 putative metal binding site [ion binding]; other site 536019006268 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 536019006269 classical (c) SDRs; Region: SDR_c; cd05233 536019006270 NAD(P) binding site [chemical binding]; other site 536019006271 active site 536019006272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 536019006273 aspartate aminotransferase; Provisional; Region: PRK05764 536019006274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019006275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019006276 homodimer interface [polypeptide binding]; other site 536019006277 catalytic residue [active] 536019006278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019006280 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 536019006281 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 536019006282 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019006283 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 536019006284 putative NAD(P) binding site [chemical binding]; other site 536019006285 active site 536019006286 putative substrate binding site [chemical binding]; other site 536019006287 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 536019006288 High-affinity nickel-transport protein; Region: NicO; cl00964 536019006289 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 536019006290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019006291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019006292 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019006293 putative effector binding pocket; other site 536019006294 dimerization interface [polypeptide binding]; other site 536019006295 amidase; Provisional; Region: PRK08310 536019006296 indole-3-acetamide amidohydrolase; Region: PLN02722 536019006297 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 536019006298 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 536019006299 active site 536019006300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019006301 dimer interface [polypeptide binding]; other site 536019006302 catalytic residues [active] 536019006303 substrate binding site [chemical binding]; other site 536019006304 Predicted acetyltransferase [General function prediction only]; Region: COG3153 536019006305 Coenzyme A binding pocket [chemical binding]; other site 536019006306 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 536019006307 Rod binding protein; Region: Rod-binding; pfam10135 536019006308 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 536019006309 HD domain; Region: HD_5; pfam13487 536019006310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019006311 Zn2+ binding site [ion binding]; other site 536019006312 Mg2+ binding site [ion binding]; other site 536019006313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019006314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019006315 DNA binding residues [nucleotide binding] 536019006316 dimerization interface [polypeptide binding]; other site 536019006317 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019006318 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 536019006319 ligand binding site [chemical binding]; other site 536019006320 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 536019006321 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 536019006322 DNA binding site [nucleotide binding] 536019006323 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019006324 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 536019006325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019006326 TPR motif; other site 536019006327 binding surface 536019006328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019006329 binding surface 536019006330 TPR motif; other site 536019006331 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019006332 EamA-like transporter family; Region: EamA; pfam00892 536019006333 EamA-like transporter family; Region: EamA; pfam00892 536019006334 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 536019006335 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 536019006336 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 536019006337 FHIPEP family; Region: FHIPEP; pfam00771 536019006338 Uncharacterized conserved protein [Function unknown]; Region: COG1359 536019006339 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536019006340 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 536019006341 Cl- selectivity filter; other site 536019006342 Cl- binding residues [ion binding]; other site 536019006343 pore gating glutamate residue; other site 536019006344 dimer interface [polypeptide binding]; other site 536019006345 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 536019006346 Transmembrane secretion effector; Region: MFS_3; pfam05977 536019006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019006348 putative substrate translocation pore; other site 536019006349 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 536019006350 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 536019006351 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 536019006352 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 536019006353 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 536019006354 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 536019006355 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 536019006356 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 536019006357 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 536019006358 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 536019006359 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536019006360 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 536019006361 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536019006362 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 536019006363 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536019006364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019006365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 536019006366 active site 536019006367 dimerization interface [polypeptide binding]; other site 536019006368 DNA binding site [nucleotide binding] 536019006369 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 536019006370 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 536019006371 chemotaxis protein; Reviewed; Region: PRK12798 536019006372 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 536019006373 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536019006374 ligand binding site [chemical binding]; other site 536019006375 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 536019006376 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 536019006377 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 536019006378 flagellin; Reviewed; Region: PRK12687 536019006379 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 536019006380 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 536019006381 flagellin; Reviewed; Region: PRK12687 536019006382 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 536019006383 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 536019006384 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 536019006385 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 536019006386 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 536019006387 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 536019006388 Uncharacterized conserved protein [Function unknown]; Region: COG3334 536019006389 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 536019006390 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 536019006391 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 536019006392 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 536019006393 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 536019006394 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 536019006395 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536019006396 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 536019006397 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 536019006398 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536019006399 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 536019006400 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 536019006401 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 536019006402 Walker A motif; other site 536019006403 ATP binding site [chemical binding]; other site 536019006404 Walker B motif; other site 536019006405 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 536019006406 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536019006407 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 536019006408 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 536019006409 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 536019006410 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 536019006411 flagellar motor protein MotA; Validated; Region: PRK09110 536019006412 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 536019006413 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 536019006414 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 536019006415 flagellar motor switch protein FliN; Region: fliN; TIGR02480 536019006416 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 536019006417 FliG C-terminal domain; Region: FliG_C; pfam01706 536019006418 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 536019006419 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 536019006420 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 536019006421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019006422 DNA binding residues [nucleotide binding] 536019006423 dimerization interface [polypeptide binding]; other site 536019006424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019006425 DNA binding residues [nucleotide binding] 536019006426 dimerization interface [polypeptide binding]; other site 536019006427 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 536019006428 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 536019006429 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 536019006430 active site 536019006431 Zn binding site [ion binding]; other site 536019006432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019006433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019006434 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 536019006435 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 536019006436 active site 536019006437 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019006438 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 536019006439 Walker A/P-loop; other site 536019006440 ATP binding site [chemical binding]; other site 536019006441 Q-loop/lid; other site 536019006442 ABC transporter signature motif; other site 536019006443 Walker B; other site 536019006444 D-loop; other site 536019006445 H-loop/switch region; other site 536019006446 TOBE domain; Region: TOBE_2; pfam08402 536019006447 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019006448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006449 dimer interface [polypeptide binding]; other site 536019006450 conserved gate region; other site 536019006451 putative PBP binding loops; other site 536019006452 ABC-ATPase subunit interface; other site 536019006453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006455 dimer interface [polypeptide binding]; other site 536019006456 conserved gate region; other site 536019006457 putative PBP binding loops; other site 536019006458 ABC-ATPase subunit interface; other site 536019006459 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019006460 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019006461 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019006462 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019006463 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019006464 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019006465 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 536019006466 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 536019006467 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 536019006468 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536019006469 RNA binding site [nucleotide binding]; other site 536019006470 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019006471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019006472 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 536019006473 dimerization interface [polypeptide binding]; other site 536019006474 substrate binding pocket [chemical binding]; other site 536019006475 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 536019006476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019006477 FAD binding site [chemical binding]; other site 536019006478 substrate binding pocket [chemical binding]; other site 536019006479 catalytic base [active] 536019006480 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019006481 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 536019006482 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 536019006483 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 536019006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 536019006485 Uncharacterized conserved protein [Function unknown]; Region: COG2308 536019006486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 536019006487 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 536019006488 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019006489 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 536019006490 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 536019006491 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019006492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019006493 active site 536019006494 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 536019006495 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 536019006496 active site 536019006497 DNA binding site [nucleotide binding] 536019006498 Int/Topo IB signature motif; other site 536019006499 catalytic residues [active] 536019006500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 536019006501 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 536019006502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019006503 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 536019006504 aldehyde dehydrogenase family 7 member; Region: PLN02315 536019006505 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 536019006506 tetrameric interface [polypeptide binding]; other site 536019006507 NAD binding site [chemical binding]; other site 536019006508 catalytic residues [active] 536019006509 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 536019006510 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 536019006511 [4Fe-4S] binding site [ion binding]; other site 536019006512 molybdopterin cofactor binding site; other site 536019006513 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 536019006514 molybdopterin cofactor binding site; other site 536019006515 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536019006516 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 536019006517 [2Fe-2S] cluster binding site [ion binding]; other site 536019006518 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 536019006519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019006520 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536019006521 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536019006522 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536019006523 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019006524 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019006525 Walker A/P-loop; other site 536019006526 ATP binding site [chemical binding]; other site 536019006527 Q-loop/lid; other site 536019006528 ABC transporter signature motif; other site 536019006529 Walker B; other site 536019006530 D-loop; other site 536019006531 H-loop/switch region; other site 536019006532 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019006533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006534 putative PBP binding loops; other site 536019006535 dimer interface [polypeptide binding]; other site 536019006536 ABC-ATPase subunit interface; other site 536019006537 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019006538 NMT1-like family; Region: NMT1_2; pfam13379 536019006539 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019006540 NMT1-like family; Region: NMT1_2; pfam13379 536019006541 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 536019006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006543 active site 536019006544 phosphorylation site [posttranslational modification] 536019006545 intermolecular recognition site; other site 536019006546 ANTAR domain; Region: ANTAR; pfam03861 536019006547 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 536019006548 putative catalytic site [active] 536019006549 putative metal binding site [ion binding]; other site 536019006550 putative phosphate binding site [ion binding]; other site 536019006551 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 536019006552 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 536019006553 putative active site [active] 536019006554 catalytic site [active] 536019006555 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 536019006556 putative active site [active] 536019006557 catalytic site [active] 536019006558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019006559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019006560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019006561 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 536019006562 trimer interface [polypeptide binding]; other site 536019006563 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 536019006564 trimer interface [polypeptide binding]; other site 536019006565 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 536019006566 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 536019006567 trimer interface [polypeptide binding]; other site 536019006568 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 536019006569 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 536019006570 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 536019006571 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 536019006572 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 536019006573 putative NAD(P) binding site [chemical binding]; other site 536019006574 putative active site [active] 536019006575 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 536019006576 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 536019006577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019006578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019006579 DNA binding residues [nucleotide binding] 536019006580 dimerization interface [polypeptide binding]; other site 536019006581 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 536019006582 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 536019006583 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019006584 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 536019006585 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 536019006586 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 536019006587 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 536019006588 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 536019006589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019006590 NAD(P) binding site [chemical binding]; other site 536019006591 active site 536019006592 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 536019006593 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 536019006594 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019006595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019006596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019006597 DNA binding residues [nucleotide binding] 536019006598 dimerization interface [polypeptide binding]; other site 536019006599 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019006600 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019006601 ligand binding site [chemical binding]; other site 536019006602 flexible hinge region; other site 536019006603 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019006604 putative switch regulator; other site 536019006605 non-specific DNA interactions [nucleotide binding]; other site 536019006606 DNA binding site [nucleotide binding] 536019006607 sequence specific DNA binding site [nucleotide binding]; other site 536019006608 putative cAMP binding site [chemical binding]; other site 536019006609 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536019006610 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019006611 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019006612 E3 interaction surface; other site 536019006613 lipoyl attachment site [posttranslational modification]; other site 536019006614 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 536019006615 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 536019006616 putative trimer interface [polypeptide binding]; other site 536019006617 putative CoA binding site [chemical binding]; other site 536019006618 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 536019006619 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 536019006620 alpha subunit interface [polypeptide binding]; other site 536019006621 TPP binding site [chemical binding]; other site 536019006622 heterodimer interface [polypeptide binding]; other site 536019006623 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019006624 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 536019006625 tetramer interface [polypeptide binding]; other site 536019006626 TPP-binding site [chemical binding]; other site 536019006627 heterodimer interface [polypeptide binding]; other site 536019006628 phosphorylation loop region [posttranslational modification] 536019006629 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 536019006630 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 536019006631 inhibitor-cofactor binding pocket; inhibition site 536019006632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019006633 catalytic residue [active] 536019006634 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 536019006635 Bacterial sugar transferase; Region: Bac_transf; pfam02397 536019006636 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536019006637 SLBB domain; Region: SLBB; pfam10531 536019006638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019006639 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 536019006640 putative ADP-binding pocket [chemical binding]; other site 536019006641 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 536019006642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019006643 putative ADP-binding pocket [chemical binding]; other site 536019006644 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 536019006645 Chain length determinant protein; Region: Wzz; pfam02706 536019006646 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019006647 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 536019006648 Pectic acid lyase; Region: Pec_lyase; pfam09492 536019006649 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 536019006650 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 536019006651 NAD(P) binding site [chemical binding]; other site 536019006652 homodimer interface [polypeptide binding]; other site 536019006653 substrate binding site [chemical binding]; other site 536019006654 active site 536019006655 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 536019006656 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019006657 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 536019006658 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 536019006659 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 536019006660 CysD dimerization site [polypeptide binding]; other site 536019006661 G1 box; other site 536019006662 putative GEF interaction site [polypeptide binding]; other site 536019006663 GTP/Mg2+ binding site [chemical binding]; other site 536019006664 Switch I region; other site 536019006665 G2 box; other site 536019006666 G3 box; other site 536019006667 Switch II region; other site 536019006668 G4 box; other site 536019006669 G5 box; other site 536019006670 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 536019006671 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 536019006672 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 536019006673 ligand-binding site [chemical binding]; other site 536019006674 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 536019006675 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536019006676 Active Sites [active] 536019006677 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536019006678 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 536019006679 sulfotransferase; Region: PLN02164 536019006680 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 536019006681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019006682 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 536019006683 putative ADP-binding pocket [chemical binding]; other site 536019006684 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 536019006685 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 536019006686 putative active site [active] 536019006687 putative substrate binding site [chemical binding]; other site 536019006688 putative cosubstrate binding site; other site 536019006689 catalytic site [active] 536019006690 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 536019006691 active site 536019006692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019006693 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 536019006694 putative NAD(P) binding site [chemical binding]; other site 536019006695 active site 536019006696 putative substrate binding site [chemical binding]; other site 536019006697 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 536019006698 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 536019006699 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 536019006700 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019006701 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536019006702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006703 dimer interface [polypeptide binding]; other site 536019006704 conserved gate region; other site 536019006705 putative PBP binding loops; other site 536019006706 ABC-ATPase subunit interface; other site 536019006707 sulfate transport protein; Provisional; Region: cysT; CHL00187 536019006708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019006709 dimer interface [polypeptide binding]; other site 536019006710 conserved gate region; other site 536019006711 putative PBP binding loops; other site 536019006712 ABC-ATPase subunit interface; other site 536019006713 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 536019006714 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 536019006715 Walker A/P-loop; other site 536019006716 ATP binding site [chemical binding]; other site 536019006717 Q-loop/lid; other site 536019006718 ABC transporter signature motif; other site 536019006719 Walker B; other site 536019006720 D-loop; other site 536019006721 H-loop/switch region; other site 536019006722 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 536019006723 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536019006724 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 536019006725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019006726 dimerization interface [polypeptide binding]; other site 536019006727 putative DNA binding site [nucleotide binding]; other site 536019006728 putative Zn2+ binding site [ion binding]; other site 536019006729 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 536019006730 cyclase homology domain; Region: CHD; cd07302 536019006731 nucleotidyl binding site; other site 536019006732 metal binding site [ion binding]; metal-binding site 536019006733 dimer interface [polypeptide binding]; other site 536019006734 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019006735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019006736 TPR motif; other site 536019006737 binding surface 536019006738 TPR repeat; Region: TPR_11; pfam13414 536019006739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019006740 TPR motif; other site 536019006741 binding surface 536019006742 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019006743 Cytochrome P450; Region: p450; cl12078 536019006744 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 536019006745 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019006746 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019006747 ligand binding site [chemical binding]; other site 536019006748 flexible hinge region; other site 536019006749 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 536019006750 non-specific DNA interactions [nucleotide binding]; other site 536019006751 DNA binding site [nucleotide binding] 536019006752 sequence specific DNA binding site [nucleotide binding]; other site 536019006753 putative cAMP binding site [chemical binding]; other site 536019006754 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 536019006755 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 536019006756 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 536019006757 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 536019006758 hydrogenase 4 subunit F; Validated; Region: PRK06458 536019006759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536019006760 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 536019006761 NADH dehydrogenase; Region: NADHdh; cl00469 536019006762 hydrogenase 4 subunit B; Validated; Region: PRK06521 536019006763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536019006764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019006765 non-specific DNA binding site [nucleotide binding]; other site 536019006766 salt bridge; other site 536019006767 sequence-specific DNA binding site [nucleotide binding]; other site 536019006768 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 536019006769 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 536019006770 PhnA protein; Region: PhnA; pfam03831 536019006771 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019006772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019006773 DNA-binding site [nucleotide binding]; DNA binding site 536019006774 FCD domain; Region: FCD; pfam07729 536019006775 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 536019006776 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 536019006777 putative ligand binding site [chemical binding]; other site 536019006778 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019006779 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019006780 TM-ABC transporter signature motif; other site 536019006781 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019006782 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019006783 TM-ABC transporter signature motif; other site 536019006784 Isochorismatase family; Region: Isochorismatase; pfam00857 536019006785 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019006786 catalytic triad [active] 536019006787 conserved cis-peptide bond; other site 536019006788 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 536019006789 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019006790 Walker A/P-loop; other site 536019006791 ATP binding site [chemical binding]; other site 536019006792 Q-loop/lid; other site 536019006793 ABC transporter signature motif; other site 536019006794 Walker B; other site 536019006795 D-loop; other site 536019006796 H-loop/switch region; other site 536019006797 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019006798 Isochorismatase family; Region: Isochorismatase; pfam00857 536019006799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019006800 catalytic triad [active] 536019006801 conserved cis-peptide bond; other site 536019006802 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 536019006803 allophanate hydrolase; Provisional; Region: PRK08186 536019006804 Amidase; Region: Amidase; cl11426 536019006805 glycogen synthase; Provisional; Region: glgA; PRK00654 536019006806 Uncharacterized conserved protein [Function unknown]; Region: COG2135 536019006807 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 536019006808 putative hydratase; Provisional; Region: PRK11413 536019006809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019006810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019006811 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019006812 putative effector binding pocket; other site 536019006813 putative dimerization interface [polypeptide binding]; other site 536019006814 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 536019006815 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019006816 Uncharacterized conserved protein [Function unknown]; Region: COG4925 536019006817 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019006818 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 536019006819 classical (c) SDRs; Region: SDR_c; cd05233 536019006820 NAD(P) binding site [chemical binding]; other site 536019006821 active site 536019006822 putative transporter; Provisional; Region: PRK12382 536019006823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 536019006824 sequence-specific DNA binding site [nucleotide binding]; other site 536019006825 salt bridge; other site 536019006826 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 536019006827 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 536019006828 catalytic residues [active] 536019006829 catalytic nucleophile [active] 536019006830 Recombinase; Region: Recombinase; pfam07508 536019006831 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 536019006832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019006833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019006834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019006835 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 536019006836 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 536019006837 Ligand Binding Site [chemical binding]; other site 536019006838 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 536019006839 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019006840 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019006841 putative NAD(P) binding site [chemical binding]; other site 536019006842 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019006843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019006844 dimerization interface [polypeptide binding]; other site 536019006845 putative DNA binding site [nucleotide binding]; other site 536019006846 putative Zn2+ binding site [ion binding]; other site 536019006847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019006848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006849 active site 536019006850 phosphorylation site [posttranslational modification] 536019006851 intermolecular recognition site; other site 536019006852 dimerization interface [polypeptide binding]; other site 536019006853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019006854 DNA binding site [nucleotide binding] 536019006855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006856 Response regulator receiver domain; Region: Response_reg; pfam00072 536019006857 active site 536019006858 phosphorylation site [posttranslational modification] 536019006859 intermolecular recognition site; other site 536019006860 dimerization interface [polypeptide binding]; other site 536019006861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 536019006862 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 536019006863 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 536019006864 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 536019006865 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536019006866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019006867 dimerization interface [polypeptide binding]; other site 536019006868 putative DNA binding site [nucleotide binding]; other site 536019006869 putative Zn2+ binding site [ion binding]; other site 536019006870 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 536019006871 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 536019006872 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 536019006873 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 536019006874 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 536019006875 NAD binding site [chemical binding]; other site 536019006876 homodimer interface [polypeptide binding]; other site 536019006877 homotetramer interface [polypeptide binding]; other site 536019006878 active site 536019006879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019006880 Coenzyme A binding pocket [chemical binding]; other site 536019006881 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 536019006882 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 536019006883 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 536019006884 putative dimer interface [polypeptide binding]; other site 536019006885 N-terminal domain interface [polypeptide binding]; other site 536019006886 putative substrate binding pocket (H-site) [chemical binding]; other site 536019006887 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 536019006888 nudix motif; other site 536019006889 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019006890 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 536019006891 putative active site [active] 536019006892 putative metal binding site [ion binding]; other site 536019006893 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 536019006894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019006895 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 536019006896 catalytic site [active] 536019006897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019006898 TPR motif; other site 536019006899 binding surface 536019006900 2-isopropylmalate synthase; Validated; Region: PRK03739 536019006901 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 536019006902 active site 536019006903 catalytic residues [active] 536019006904 metal binding site [ion binding]; metal-binding site 536019006905 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 536019006906 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 536019006907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 536019006908 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 536019006909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019006910 putative substrate translocation pore; other site 536019006911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019006912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019006913 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 536019006914 putative effector binding pocket; other site 536019006915 putative dimerization interface [polypeptide binding]; other site 536019006916 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 536019006917 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 536019006918 FAD binding pocket [chemical binding]; other site 536019006919 FAD binding motif [chemical binding]; other site 536019006920 phosphate binding motif [ion binding]; other site 536019006921 NAD binding pocket [chemical binding]; other site 536019006922 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 536019006923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536019006924 N-terminal plug; other site 536019006925 ligand-binding site [chemical binding]; other site 536019006926 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 536019006927 Putative ammonia monooxygenase; Region: AmoA; pfam05145 536019006928 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 536019006929 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 536019006930 Uncharacterized conserved protein [Function unknown]; Region: COG1359 536019006931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019006932 classical (c) SDRs; Region: SDR_c; cd05233 536019006933 NAD(P) binding site [chemical binding]; other site 536019006934 active site 536019006935 Uncharacterized conserved protein [Function unknown]; Region: COG1416 536019006936 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 536019006937 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 536019006938 anthranilate synthase; Provisional; Region: PRK13566 536019006939 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 536019006940 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 536019006941 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 536019006942 glutamine binding [chemical binding]; other site 536019006943 catalytic triad [active] 536019006944 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536019006945 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 536019006946 tetramer interface [polypeptide binding]; other site 536019006947 active site 536019006948 Mg2+/Mn2+ binding site [ion binding]; other site 536019006949 Predicted deacylase [General function prediction only]; Region: COG3608 536019006950 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 536019006951 active site 536019006952 Zn binding site [ion binding]; other site 536019006953 MFS transport protein AraJ; Provisional; Region: PRK10091 536019006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019006955 putative substrate translocation pore; other site 536019006956 mercuric reductase; Validated; Region: PRK06370 536019006957 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019006958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019006959 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019006960 Predicted membrane protein [Function unknown]; Region: COG3918 536019006961 maltose O-acetyltransferase; Provisional; Region: PRK10092 536019006962 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 536019006963 active site 536019006964 substrate binding site [chemical binding]; other site 536019006965 trimer interface [polypeptide binding]; other site 536019006966 CoA binding site [chemical binding]; other site 536019006967 sensor protein QseC; Provisional; Region: PRK10337 536019006968 HAMP domain; Region: HAMP; pfam00672 536019006969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019006970 dimer interface [polypeptide binding]; other site 536019006971 phosphorylation site [posttranslational modification] 536019006972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019006973 ATP binding site [chemical binding]; other site 536019006974 Mg2+ binding site [ion binding]; other site 536019006975 G-X-G motif; other site 536019006976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019006977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019006978 active site 536019006979 phosphorylation site [posttranslational modification] 536019006980 intermolecular recognition site; other site 536019006981 dimerization interface [polypeptide binding]; other site 536019006982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019006983 DNA binding site [nucleotide binding] 536019006984 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 536019006985 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 536019006986 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 536019006987 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 536019006988 conserved cys residue [active] 536019006989 Isochorismatase family; Region: Isochorismatase; pfam00857 536019006990 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 536019006991 catalytic triad [active] 536019006992 conserved cis-peptide bond; other site 536019006993 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 536019006994 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 536019006995 Potassium binding sites [ion binding]; other site 536019006996 Cesium cation binding sites [ion binding]; other site 536019006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 536019006998 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 536019006999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019007000 Walker A motif; other site 536019007001 ATP binding site [chemical binding]; other site 536019007002 Walker B motif; other site 536019007003 hypothetical protein; Validated; Region: PRK09039 536019007004 Cytochrome c2 [Energy production and conversion]; Region: COG3474 536019007005 thymidine kinase; Provisional; Region: PRK04296 536019007006 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 536019007007 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 536019007008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007009 dimer interface [polypeptide binding]; other site 536019007010 conserved gate region; other site 536019007011 putative PBP binding loops; other site 536019007012 ABC-ATPase subunit interface; other site 536019007013 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 536019007014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019007015 Walker A/P-loop; other site 536019007016 ATP binding site [chemical binding]; other site 536019007017 Q-loop/lid; other site 536019007018 ABC transporter signature motif; other site 536019007019 Walker B; other site 536019007020 D-loop; other site 536019007021 H-loop/switch region; other site 536019007022 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 536019007023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019007024 ATP binding site [chemical binding]; other site 536019007025 Mg2+ binding site [ion binding]; other site 536019007026 G-X-G motif; other site 536019007027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019007028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019007029 active site 536019007030 phosphorylation site [posttranslational modification] 536019007031 intermolecular recognition site; other site 536019007032 dimerization interface [polypeptide binding]; other site 536019007033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019007034 DNA binding site [nucleotide binding] 536019007035 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 536019007036 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 536019007037 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 536019007038 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 536019007039 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 536019007040 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 536019007041 Protein of unknown function DUF58; Region: DUF58; pfam01882 536019007042 MoxR-like ATPases [General function prediction only]; Region: COG0714 536019007043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 536019007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 536019007045 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 536019007046 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 536019007047 putative active site [active] 536019007048 putative CoA binding site [chemical binding]; other site 536019007049 nudix motif; other site 536019007050 metal binding site [ion binding]; metal-binding site 536019007051 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 536019007052 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 536019007053 active site 536019007054 NTP binding site [chemical binding]; other site 536019007055 metal binding triad [ion binding]; metal-binding site 536019007056 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 536019007057 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 536019007058 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 536019007059 active site 536019007060 catalytic residues [active] 536019007061 Predicted small metal-binding protein [Function unknown]; Region: COG5466 536019007062 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 536019007063 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 536019007064 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 536019007065 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 536019007066 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 536019007067 DNA binding residues [nucleotide binding] 536019007068 dimer interface [polypeptide binding]; other site 536019007069 [2Fe-2S] cluster binding site [ion binding]; other site 536019007070 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 536019007071 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019007072 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019007073 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 536019007074 Walker A/P-loop; other site 536019007075 ATP binding site [chemical binding]; other site 536019007076 Q-loop/lid; other site 536019007077 ABC transporter signature motif; other site 536019007078 Walker B; other site 536019007079 D-loop; other site 536019007080 H-loop/switch region; other site 536019007081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019007082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019007083 Walker A/P-loop; other site 536019007084 ATP binding site [chemical binding]; other site 536019007085 Q-loop/lid; other site 536019007086 ABC transporter signature motif; other site 536019007087 Walker B; other site 536019007088 D-loop; other site 536019007089 H-loop/switch region; other site 536019007090 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019007091 Epoxide hydrolase N terminus; Region: EHN; pfam06441 536019007092 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 536019007093 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 536019007094 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 536019007095 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 536019007096 [2Fe-2S] cluster binding site [ion binding]; other site 536019007097 cytochrome b; Provisional; Region: CYTB; MTH00119 536019007098 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 536019007099 Qi binding site; other site 536019007100 intrachain domain interface; other site 536019007101 interchain domain interface [polypeptide binding]; other site 536019007102 heme bH binding site [chemical binding]; other site 536019007103 heme bL binding site [chemical binding]; other site 536019007104 Qo binding site; other site 536019007105 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 536019007106 interchain domain interface [polypeptide binding]; other site 536019007107 intrachain domain interface; other site 536019007108 Qi binding site; other site 536019007109 Qo binding site; other site 536019007110 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 536019007111 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536019007112 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 536019007113 active site 536019007114 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 536019007115 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536019007116 phosphate binding site [ion binding]; other site 536019007117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019007118 active site 536019007119 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 536019007120 putative active site [active] 536019007121 putative catalytic site [active] 536019007122 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 536019007123 putative active site [active] 536019007124 putative catalytic site [active] 536019007125 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536019007126 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 536019007127 Cl binding site [ion binding]; other site 536019007128 oligomer interface [polypeptide binding]; other site 536019007129 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 536019007130 GTP-binding protein YchF; Reviewed; Region: PRK09601 536019007131 YchF GTPase; Region: YchF; cd01900 536019007132 G1 box; other site 536019007133 GTP/Mg2+ binding site [chemical binding]; other site 536019007134 Switch I region; other site 536019007135 G2 box; other site 536019007136 Switch II region; other site 536019007137 G3 box; other site 536019007138 G4 box; other site 536019007139 G5 box; other site 536019007140 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 536019007141 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 536019007142 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 536019007143 active site 536019007144 S2 subsite; other site 536019007145 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 536019007146 putative active site [active] 536019007147 catalytic residue [active] 536019007148 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 536019007149 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 536019007150 5S rRNA interface [nucleotide binding]; other site 536019007151 CTC domain interface [polypeptide binding]; other site 536019007152 L16 interface [polypeptide binding]; other site 536019007153 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019007154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019007155 putative Zn2+ binding site [ion binding]; other site 536019007156 putative DNA binding site [nucleotide binding]; other site 536019007157 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019007158 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019007159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019007160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019007161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019007162 putative substrate translocation pore; other site 536019007163 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536019007164 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536019007165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007167 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 536019007168 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 536019007169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019007170 active site 536019007171 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019007172 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019007173 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019007174 active site 536019007175 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 536019007176 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 536019007177 Uncharacterized conserved protein [Function unknown]; Region: COG1565 536019007178 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 536019007179 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 536019007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 536019007181 Uncharacterized conserved protein [Function unknown]; Region: COG5465 536019007182 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 536019007183 dimer interface [polypeptide binding]; other site 536019007184 putative tRNA-binding site [nucleotide binding]; other site 536019007185 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019007186 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 536019007187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019007188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019007189 ATP binding site [chemical binding]; other site 536019007190 Mg2+ binding site [ion binding]; other site 536019007191 G-X-G motif; other site 536019007192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019007193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019007194 active site 536019007195 phosphorylation site [posttranslational modification] 536019007196 intermolecular recognition site; other site 536019007197 dimerization interface [polypeptide binding]; other site 536019007198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019007199 DNA binding site [nucleotide binding] 536019007200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019007201 MarR family; Region: MarR_2; pfam12802 536019007202 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536019007203 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 536019007204 homodimer interface [polypeptide binding]; other site 536019007205 substrate-cofactor binding pocket; other site 536019007206 catalytic residue [active] 536019007207 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536019007208 BA14K-like protein; Region: BA14K; pfam07886 536019007209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019007210 DNA-binding site [nucleotide binding]; DNA binding site 536019007211 RNA-binding motif; other site 536019007212 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019007213 DNA-binding site [nucleotide binding]; DNA binding site 536019007214 RNA-binding motif; other site 536019007215 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 536019007216 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 536019007217 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536019007218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019007219 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019007220 DNA-binding site [nucleotide binding]; DNA binding site 536019007221 RNA-binding motif; other site 536019007222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019007223 TPR motif; other site 536019007224 binding surface 536019007225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019007226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019007227 binding surface 536019007228 TPR motif; other site 536019007229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019007230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019007231 binding surface 536019007232 Tetratricopeptide repeat; Region: TPR_16; pfam13432 536019007233 TPR motif; other site 536019007234 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 536019007235 Uncharacterized conserved protein [Function unknown]; Region: COG5507 536019007236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 536019007237 putative dimer interface [polypeptide binding]; other site 536019007238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019007239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019007240 sequence-specific DNA binding site [nucleotide binding]; other site 536019007241 salt bridge; other site 536019007242 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 536019007243 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 536019007244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019007245 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019007246 EamA-like transporter family; Region: EamA; pfam00892 536019007247 excinuclease ABC subunit B; Provisional; Region: PRK05298 536019007248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019007249 ATP binding site [chemical binding]; other site 536019007250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019007251 nucleotide binding region [chemical binding]; other site 536019007252 ATP-binding site [chemical binding]; other site 536019007253 Ultra-violet resistance protein B; Region: UvrB; pfam12344 536019007254 UvrB/uvrC motif; Region: UVR; pfam02151 536019007255 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 536019007256 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 536019007257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019007258 S-adenosylmethionine binding site [chemical binding]; other site 536019007259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019007260 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 536019007261 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 536019007262 putative active site [active] 536019007263 putative metal binding site [ion binding]; other site 536019007264 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 536019007265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 536019007266 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 536019007267 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019007268 FAD binding domain; Region: FAD_binding_4; pfam01565 536019007269 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 536019007270 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 536019007271 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 536019007272 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 536019007273 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536019007274 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019007275 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019007276 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019007277 active site pocket [active] 536019007278 choline dehydrogenase; Validated; Region: PRK02106 536019007279 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019007280 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 536019007281 ATP binding site [chemical binding]; other site 536019007282 active site 536019007283 substrate binding site [chemical binding]; other site 536019007284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019007285 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019007286 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019007287 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 536019007288 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019007289 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019007290 Predicted flavoprotein [General function prediction only]; Region: COG0431 536019007291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019007292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019007293 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019007294 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019007295 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019007296 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019007297 NAD(P) binding site [chemical binding]; other site 536019007298 tetracycline repressor protein TetR; Provisional; Region: PRK13756 536019007299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019007300 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 536019007301 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019007302 homotrimer interaction site [polypeptide binding]; other site 536019007303 putative active site [active] 536019007304 Serine hydrolase; Region: Ser_hydrolase; cl17834 536019007305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019007306 Helix-turn-helix domain; Region: HTH_18; pfam12833 536019007307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007308 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 536019007309 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 536019007310 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 536019007311 active site 536019007312 catalytic residues [active] 536019007313 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 536019007314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019007315 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 536019007316 Walker A/P-loop; other site 536019007317 ATP binding site [chemical binding]; other site 536019007318 Q-loop/lid; other site 536019007319 ABC transporter signature motif; other site 536019007320 Walker B; other site 536019007321 D-loop; other site 536019007322 H-loop/switch region; other site 536019007323 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 536019007324 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019007325 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019007326 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 536019007327 Domain of unknown function DUF21; Region: DUF21; pfam01595 536019007328 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536019007329 Transporter associated domain; Region: CorC_HlyC; smart01091 536019007330 LssY C-terminus; Region: LssY_C; pfam14067 536019007331 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 536019007332 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536019007333 putative active site pocket [active] 536019007334 dimerization interface [polypeptide binding]; other site 536019007335 putative catalytic residue [active] 536019007336 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 536019007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 536019007338 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 536019007339 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 536019007340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019007341 binding surface 536019007342 Tetratricopeptide repeat; Region: TPR_16; pfam13432 536019007343 TPR motif; other site 536019007344 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 536019007345 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 536019007346 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536019007347 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536019007348 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536019007349 putative active site [active] 536019007350 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536019007351 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536019007352 putative active site [active] 536019007353 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 536019007354 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 536019007355 NADP binding site [chemical binding]; other site 536019007356 homopentamer interface [polypeptide binding]; other site 536019007357 substrate binding site [chemical binding]; other site 536019007358 active site 536019007359 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019007360 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 536019007361 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 536019007362 putative ribose interaction site [chemical binding]; other site 536019007363 putative ADP binding site [chemical binding]; other site 536019007364 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 536019007365 active site 536019007366 nucleotide binding site [chemical binding]; other site 536019007367 HIGH motif; other site 536019007368 KMSKS motif; other site 536019007369 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 536019007370 dimer interface [polypeptide binding]; other site 536019007371 active site 536019007372 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 536019007373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019007374 active site 536019007375 motif I; other site 536019007376 motif II; other site 536019007377 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 536019007378 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019007379 putative metal binding site; other site 536019007380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019007381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019007382 putative DNA binding site [nucleotide binding]; other site 536019007383 putative Zn2+ binding site [ion binding]; other site 536019007384 AsnC family; Region: AsnC_trans_reg; pfam01037 536019007385 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 536019007386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019007387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019007388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007390 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019007391 putative effector binding pocket; other site 536019007392 dimerization interface [polypeptide binding]; other site 536019007393 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 536019007394 elongation factor G; Reviewed; Region: PRK12740 536019007395 G1 box; other site 536019007396 putative GEF interaction site [polypeptide binding]; other site 536019007397 GTP/Mg2+ binding site [chemical binding]; other site 536019007398 Switch I region; other site 536019007399 G2 box; other site 536019007400 G3 box; other site 536019007401 Switch II region; other site 536019007402 G4 box; other site 536019007403 G5 box; other site 536019007404 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 536019007405 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 536019007406 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 536019007407 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019007408 aspartate aminotransferase; Provisional; Region: PRK05764 536019007409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019007410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019007411 homodimer interface [polypeptide binding]; other site 536019007412 catalytic residue [active] 536019007413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019007414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019007415 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019007416 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 536019007417 putative C-terminal domain interface [polypeptide binding]; other site 536019007418 putative GSH binding site (G-site) [chemical binding]; other site 536019007419 putative dimer interface [polypeptide binding]; other site 536019007420 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 536019007421 N-terminal domain interface [polypeptide binding]; other site 536019007422 dimer interface [polypeptide binding]; other site 536019007423 substrate binding pocket (H-site) [chemical binding]; other site 536019007424 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019007425 DNA-binding site [nucleotide binding]; DNA binding site 536019007426 RNA-binding motif; other site 536019007427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007429 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019007430 putative effector binding pocket; other site 536019007431 dimerization interface [polypeptide binding]; other site 536019007432 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536019007433 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 536019007434 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 536019007435 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536019007436 DNA binding site [nucleotide binding] 536019007437 active site 536019007438 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019007439 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019007440 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019007441 catalytic residue [active] 536019007442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536019007443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019007444 Coenzyme A binding pocket [chemical binding]; other site 536019007445 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019007446 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019007447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007448 dimer interface [polypeptide binding]; other site 536019007449 conserved gate region; other site 536019007450 putative PBP binding loops; other site 536019007451 ABC-ATPase subunit interface; other site 536019007452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019007453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007454 dimer interface [polypeptide binding]; other site 536019007455 conserved gate region; other site 536019007456 putative PBP binding loops; other site 536019007457 ABC-ATPase subunit interface; other site 536019007458 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 536019007459 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 536019007460 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 536019007461 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 536019007462 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019007463 homotrimer interaction site [polypeptide binding]; other site 536019007464 putative active site [active] 536019007465 SIR2-like domain; Region: SIR2_2; pfam13289 536019007466 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 536019007467 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019007468 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019007469 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 536019007470 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019007471 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019007472 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 536019007473 IMP binding site; other site 536019007474 dimer interface [polypeptide binding]; other site 536019007475 interdomain contacts; other site 536019007476 partial ornithine binding site; other site 536019007477 Bacterial SH3 domain; Region: SH3_3; pfam08239 536019007478 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 536019007479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019007480 active site 536019007481 metal binding site [ion binding]; metal-binding site 536019007482 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 536019007483 nucleoside/Zn binding site; other site 536019007484 dimer interface [polypeptide binding]; other site 536019007485 catalytic motif [active] 536019007486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019007487 putative DNA binding site [nucleotide binding]; other site 536019007488 putative Zn2+ binding site [ion binding]; other site 536019007489 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019007490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019007491 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019007492 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 536019007493 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 536019007494 classical (c) SDRs; Region: SDR_c; cd05233 536019007495 NAD(P) binding site [chemical binding]; other site 536019007496 active site 536019007497 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019007498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019007501 dimerization interface [polypeptide binding]; other site 536019007502 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019007503 RibD C-terminal domain; Region: RibD_C; cl17279 536019007504 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 536019007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019007506 S-adenosylmethionine binding site [chemical binding]; other site 536019007507 manganese transport protein MntH; Reviewed; Region: PRK00701 536019007508 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 536019007509 manganese transport regulator MntR; Provisional; Region: PRK11050 536019007510 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 536019007511 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 536019007512 Predicted metalloprotease [General function prediction only]; Region: COG2321 536019007513 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 536019007514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019007515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019007516 putative substrate translocation pore; other site 536019007517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019007518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019007519 active site 536019007520 catalytic tetrad [active] 536019007521 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 536019007522 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 536019007523 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 536019007524 catalytic site [active] 536019007525 subunit interface [polypeptide binding]; other site 536019007526 Uncharacterized conserved protein [Function unknown]; Region: COG1610 536019007527 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 536019007528 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019007529 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019007530 putative NAD(P) binding site [chemical binding]; other site 536019007531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019007534 dimerization interface [polypeptide binding]; other site 536019007535 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 536019007536 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 536019007537 replicative DNA helicase; Provisional; Region: PRK05973 536019007538 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 536019007539 Predicted acetyltransferase [General function prediction only]; Region: COG3981 536019007540 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 536019007541 Coenzyme A binding pocket [chemical binding]; other site 536019007542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019007543 MFS transport protein AraJ; Provisional; Region: PRK10091 536019007544 putative substrate translocation pore; other site 536019007545 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 536019007546 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 536019007547 PhoU domain; Region: PhoU; pfam01895 536019007548 Predicted integral membrane protein [Function unknown]; Region: COG5455 536019007549 DNA primase; Validated; Region: dnaG; PRK05667 536019007550 CHC2 zinc finger; Region: zf-CHC2; pfam01807 536019007551 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 536019007552 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 536019007553 active site 536019007554 metal binding site [ion binding]; metal-binding site 536019007555 interdomain interaction site; other site 536019007556 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 536019007557 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 536019007558 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 536019007559 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 536019007560 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 536019007561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019007562 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 536019007563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019007564 DNA binding residues [nucleotide binding] 536019007565 Uncharacterized conserved protein [Function unknown]; Region: COG4274 536019007566 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 536019007567 Domain of unknown function (DUF333); Region: DUF333; pfam03891 536019007568 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 536019007569 Predicted transcriptional regulators [Transcription]; Region: COG1695 536019007570 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 536019007571 yiaA/B two helix domain; Region: YiaAB; cl01759 536019007572 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 536019007573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019007574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019007575 WHG domain; Region: WHG; pfam13305 536019007576 Uncharacterized conserved protein [Function unknown]; Region: COG5453 536019007577 Methyltransferase domain; Region: Methyltransf_25; pfam13649 536019007578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019007579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019007580 metal binding site [ion binding]; metal-binding site 536019007581 active site 536019007582 I-site; other site 536019007583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019007584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019007585 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019007586 Cupin domain; Region: Cupin_2; pfam07883 536019007587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007589 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019007590 putative effector binding pocket; other site 536019007591 dimerization interface [polypeptide binding]; other site 536019007592 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019007593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019007594 putative DNA binding site [nucleotide binding]; other site 536019007595 putative Zn2+ binding site [ion binding]; other site 536019007596 AsnC family; Region: AsnC_trans_reg; pfam01037 536019007597 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 536019007598 Predicted membrane protein [Function unknown]; Region: COG4541 536019007599 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 536019007600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019007601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019007602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019007603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019007604 dimerization interface [polypeptide binding]; other site 536019007605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019007606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019007607 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 536019007608 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019007609 dimer interface [polypeptide binding]; other site 536019007610 active site 536019007611 short chain dehydrogenase; Provisional; Region: PRK06179 536019007612 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536019007613 NADP binding site [chemical binding]; other site 536019007614 active site 536019007615 steroid binding site; other site 536019007616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019007617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 536019007618 putative dimer interface [polypeptide binding]; other site 536019007619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019007620 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019007621 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019007622 protein binding site [polypeptide binding]; other site 536019007623 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 536019007624 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019007625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019007626 protein binding site [polypeptide binding]; other site 536019007627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019007628 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019007629 DNA binding residues [nucleotide binding] 536019007630 dimerization interface [polypeptide binding]; other site 536019007631 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 536019007632 putative active site [active] 536019007633 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 536019007634 short chain dehydrogenase; Provisional; Region: PRK08278 536019007635 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 536019007636 NAD(P) binding site [chemical binding]; other site 536019007637 homodimer interface [polypeptide binding]; other site 536019007638 active site 536019007639 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 536019007640 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 536019007641 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 536019007642 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536019007643 ligand binding site [chemical binding]; other site 536019007644 hypothetical protein; Provisional; Region: PRK05170 536019007645 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 536019007646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536019007647 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 536019007648 active site 536019007649 catalytic residues [active] 536019007650 DNA binding site [nucleotide binding] 536019007651 Int/Topo IB signature motif; other site 536019007652 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 536019007653 AAA domain; Region: AAA_23; pfam13476 536019007654 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 536019007655 integrase; Provisional; Region: PRK09692 536019007656 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 536019007657 active site 536019007658 Int/Topo IB signature motif; other site 536019007659 Cupin domain; Region: Cupin_2; pfam07883 536019007660 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536019007661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007662 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019007663 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007665 dimer interface [polypeptide binding]; other site 536019007666 conserved gate region; other site 536019007667 putative PBP binding loops; other site 536019007668 ABC-ATPase subunit interface; other site 536019007669 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019007670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007671 dimer interface [polypeptide binding]; other site 536019007672 conserved gate region; other site 536019007673 putative PBP binding loops; other site 536019007674 ABC-ATPase subunit interface; other site 536019007675 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019007676 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019007677 Walker A/P-loop; other site 536019007678 ATP binding site [chemical binding]; other site 536019007679 Q-loop/lid; other site 536019007680 ABC transporter signature motif; other site 536019007681 Walker B; other site 536019007682 D-loop; other site 536019007683 H-loop/switch region; other site 536019007684 TOBE domain; Region: TOBE_2; pfam08402 536019007685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019007686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019007687 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019007688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019007689 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019007690 active site 536019007691 catalytic tetrad [active] 536019007692 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536019007693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019007694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007695 alpha-galactosidase; Provisional; Region: PRK15076 536019007696 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 536019007697 NAD binding site [chemical binding]; other site 536019007698 sugar binding site [chemical binding]; other site 536019007699 divalent metal binding site [ion binding]; other site 536019007700 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019007701 dimer interface [polypeptide binding]; other site 536019007702 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 536019007703 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019007704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019007705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007706 dimer interface [polypeptide binding]; other site 536019007707 conserved gate region; other site 536019007708 putative PBP binding loops; other site 536019007709 ABC-ATPase subunit interface; other site 536019007710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007712 dimer interface [polypeptide binding]; other site 536019007713 conserved gate region; other site 536019007714 putative PBP binding loops; other site 536019007715 ABC-ATPase subunit interface; other site 536019007716 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 536019007717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019007718 Walker A/P-loop; other site 536019007719 ATP binding site [chemical binding]; other site 536019007720 Q-loop/lid; other site 536019007721 ABC transporter signature motif; other site 536019007722 Walker B; other site 536019007723 D-loop; other site 536019007724 H-loop/switch region; other site 536019007725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019007726 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019007727 Walker A/P-loop; other site 536019007728 ATP binding site [chemical binding]; other site 536019007729 Q-loop/lid; other site 536019007730 ABC transporter signature motif; other site 536019007731 Walker B; other site 536019007732 D-loop; other site 536019007733 H-loop/switch region; other site 536019007734 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019007735 alpha-galactosidase; Provisional; Region: PRK15076 536019007736 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 536019007737 NAD binding site [chemical binding]; other site 536019007738 sugar binding site [chemical binding]; other site 536019007739 divalent metal binding site [ion binding]; other site 536019007740 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019007741 dimer interface [polypeptide binding]; other site 536019007742 zinc-binding protein; Provisional; Region: PRK01343 536019007743 Maf-like protein; Region: Maf; pfam02545 536019007744 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 536019007745 active site 536019007746 dimer interface [polypeptide binding]; other site 536019007747 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 536019007748 rRNA binding site [nucleotide binding]; other site 536019007749 predicted 30S ribosome binding site; other site 536019007750 Low molecular weight phosphatase family; Region: LMWPc; cl00105 536019007751 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 536019007752 active site 536019007753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 536019007754 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 536019007755 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 536019007756 NAD binding site [chemical binding]; other site 536019007757 dimerization interface [polypeptide binding]; other site 536019007758 product binding site; other site 536019007759 substrate binding site [chemical binding]; other site 536019007760 zinc binding site [ion binding]; other site 536019007761 catalytic residues [active] 536019007762 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 536019007763 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 536019007764 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 536019007765 hinge; other site 536019007766 active site 536019007767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 536019007768 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 536019007769 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019007770 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019007771 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019007772 putative active site [active] 536019007773 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 536019007774 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 536019007775 metal binding site [ion binding]; metal-binding site 536019007776 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019007777 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019007778 TM-ABC transporter signature motif; other site 536019007779 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019007780 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019007781 Walker A/P-loop; other site 536019007782 ATP binding site [chemical binding]; other site 536019007783 Q-loop/lid; other site 536019007784 ABC transporter signature motif; other site 536019007785 Walker B; other site 536019007786 D-loop; other site 536019007787 H-loop/switch region; other site 536019007788 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019007789 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019007790 Walker A/P-loop; other site 536019007791 ATP binding site [chemical binding]; other site 536019007792 Q-loop/lid; other site 536019007793 ABC transporter signature motif; other site 536019007794 Walker B; other site 536019007795 D-loop; other site 536019007796 H-loop/switch region; other site 536019007797 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019007798 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 536019007799 ligand binding site [chemical binding]; other site 536019007800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019007801 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 536019007802 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 536019007803 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 536019007804 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 536019007805 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 536019007806 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 536019007807 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 536019007808 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 536019007809 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 536019007810 O-Antigen ligase; Region: Wzy_C; pfam04932 536019007811 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 536019007812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019007813 active site 536019007814 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 536019007815 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 536019007816 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 536019007817 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536019007818 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 536019007819 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 536019007820 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 536019007821 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 536019007822 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 536019007823 homodimer interface [polypeptide binding]; other site 536019007824 NADP binding site [chemical binding]; other site 536019007825 substrate binding site [chemical binding]; other site 536019007826 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019007827 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 536019007828 conserved cys residue [active] 536019007829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019007830 von Willebrand factor type A domain; Region: VWA_2; pfam13519 536019007831 metal ion-dependent adhesion site (MIDAS); other site 536019007832 phosphogluconate dehydratase; Validated; Region: PRK09054 536019007833 6-phosphogluconate dehydratase; Region: edd; TIGR01196 536019007834 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 536019007835 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 536019007836 putative active site [active] 536019007837 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 536019007838 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 536019007839 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 536019007840 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 536019007841 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 536019007842 putative NAD(P) binding site [chemical binding]; other site 536019007843 active site 536019007844 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 536019007845 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 536019007846 Bacterial SH3 domain; Region: SH3_3; pfam08239 536019007847 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019007848 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019007849 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536019007850 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 536019007851 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019007852 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 536019007853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019007854 motif II; other site 536019007855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 536019007856 active site 536019007857 phosphorylation site [posttranslational modification] 536019007858 intermolecular recognition site; other site 536019007859 dimerization interface [polypeptide binding]; other site 536019007860 isocitrate lyase; Provisional; Region: PRK15063 536019007861 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536019007862 tetramer interface [polypeptide binding]; other site 536019007863 active site 536019007864 Mg2+/Mn2+ binding site [ion binding]; other site 536019007865 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019007866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019007867 non-specific DNA binding site [nucleotide binding]; other site 536019007868 salt bridge; other site 536019007869 sequence-specific DNA binding site [nucleotide binding]; other site 536019007870 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 536019007871 Domain of unknown function (DUF955); Region: DUF955; pfam06114 536019007872 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 536019007873 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019007874 EamA-like transporter family; Region: EamA; pfam00892 536019007875 EamA-like transporter family; Region: EamA; pfam00892 536019007876 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 536019007877 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019007878 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019007879 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 536019007880 Walker A/P-loop; other site 536019007881 ATP binding site [chemical binding]; other site 536019007882 Q-loop/lid; other site 536019007883 ABC transporter signature motif; other site 536019007884 Walker B; other site 536019007885 D-loop; other site 536019007886 H-loop/switch region; other site 536019007887 TOBE domain; Region: TOBE_2; pfam08402 536019007888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007889 dimer interface [polypeptide binding]; other site 536019007890 conserved gate region; other site 536019007891 putative PBP binding loops; other site 536019007892 ABC-ATPase subunit interface; other site 536019007893 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019007894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007895 dimer interface [polypeptide binding]; other site 536019007896 conserved gate region; other site 536019007897 putative PBP binding loops; other site 536019007898 ABC-ATPase subunit interface; other site 536019007899 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 536019007900 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 536019007901 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 536019007902 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 536019007903 acyl-activating enzyme (AAE) consensus motif; other site 536019007904 putative AMP binding site [chemical binding]; other site 536019007905 putative active site [active] 536019007906 putative CoA binding site [chemical binding]; other site 536019007907 PAS domain; Region: PAS; smart00091 536019007908 PAS domain; Region: PAS_9; pfam13426 536019007909 PAS domain; Region: PAS_9; pfam13426 536019007910 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 536019007911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019007912 putative active site [active] 536019007913 heme pocket [chemical binding]; other site 536019007914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019007915 dimer interface [polypeptide binding]; other site 536019007916 phosphorylation site [posttranslational modification] 536019007917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019007918 ATP binding site [chemical binding]; other site 536019007919 Mg2+ binding site [ion binding]; other site 536019007920 G-X-G motif; other site 536019007921 Uncharacterized conserved protein [Function unknown]; Region: COG5490 536019007922 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 536019007923 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 536019007924 salt bridge; other site 536019007925 non-specific DNA binding site [nucleotide binding]; other site 536019007926 sequence-specific DNA binding site [nucleotide binding]; other site 536019007927 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019007928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019007929 DNA-binding site [nucleotide binding]; DNA binding site 536019007930 FCD domain; Region: FCD; pfam07729 536019007931 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019007932 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019007933 active site pocket [active] 536019007934 NIPSNAP; Region: NIPSNAP; pfam07978 536019007935 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 536019007936 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019007937 active site pocket [active] 536019007938 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019007939 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019007940 active site pocket [active] 536019007941 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019007942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019007943 DNA-binding site [nucleotide binding]; DNA binding site 536019007944 FCD domain; Region: FCD; pfam07729 536019007945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019007946 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019007947 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019007948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007949 dimer interface [polypeptide binding]; other site 536019007950 conserved gate region; other site 536019007951 putative PBP binding loops; other site 536019007952 ABC-ATPase subunit interface; other site 536019007953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 536019007954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019007955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019007956 dimer interface [polypeptide binding]; other site 536019007957 conserved gate region; other site 536019007958 putative PBP binding loops; other site 536019007959 ABC-ATPase subunit interface; other site 536019007960 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019007961 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019007962 Walker A/P-loop; other site 536019007963 ATP binding site [chemical binding]; other site 536019007964 Q-loop/lid; other site 536019007965 ABC transporter signature motif; other site 536019007966 Walker B; other site 536019007967 D-loop; other site 536019007968 H-loop/switch region; other site 536019007969 TOBE domain; Region: TOBE; pfam03459 536019007970 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019007971 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019007972 active site pocket [active] 536019007973 hypothetical protein; Validated; Region: PRK08245 536019007974 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019007975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019007976 catalytic loop [active] 536019007977 iron binding site [ion binding]; other site 536019007978 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019007979 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019007980 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019007981 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019007982 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019007983 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019007984 Cupin domain; Region: Cupin_2; pfam07883 536019007985 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019007986 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 536019007987 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019007988 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019007989 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 536019007990 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 536019007991 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019007992 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019007993 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019007994 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019007995 active site 536019007996 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 536019007997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019007998 substrate binding pocket [chemical binding]; other site 536019007999 membrane-bound complex binding site; other site 536019008000 hinge residues; other site 536019008001 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019008002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008003 dimer interface [polypeptide binding]; other site 536019008004 conserved gate region; other site 536019008005 putative PBP binding loops; other site 536019008006 ABC-ATPase subunit interface; other site 536019008007 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019008008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008009 dimer interface [polypeptide binding]; other site 536019008010 conserved gate region; other site 536019008011 putative PBP binding loops; other site 536019008012 ABC-ATPase subunit interface; other site 536019008013 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 536019008014 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019008015 Walker A/P-loop; other site 536019008016 ATP binding site [chemical binding]; other site 536019008017 Q-loop/lid; other site 536019008018 ABC transporter signature motif; other site 536019008019 Walker B; other site 536019008020 D-loop; other site 536019008021 H-loop/switch region; other site 536019008022 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019008023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008024 DNA-binding site [nucleotide binding]; DNA binding site 536019008025 FCD domain; Region: FCD; pfam07729 536019008026 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 536019008027 NADH dehydrogenase subunit D; Validated; Region: PRK06075 536019008028 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019008029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019008030 putative substrate translocation pore; other site 536019008031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019008032 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536019008033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019008034 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019008035 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 536019008036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019008037 active site 536019008038 motif I; other site 536019008039 motif II; other site 536019008040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 536019008041 AAA ATPase domain; Region: AAA_16; pfam13191 536019008042 Walker A motif; other site 536019008043 ATP binding site [chemical binding]; other site 536019008044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019008045 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 536019008046 putative ADP-binding pocket [chemical binding]; other site 536019008047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019008048 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 536019008049 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019008050 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 536019008051 Ligand binding site; other site 536019008052 Putative Catalytic site; other site 536019008053 DXD motif; other site 536019008054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008055 S-adenosylmethionine binding site [chemical binding]; other site 536019008056 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 536019008057 Sulfatase; Region: Sulfatase; cl17466 536019008058 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 536019008059 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 536019008060 Ligand binding site; other site 536019008061 Putative Catalytic site; other site 536019008062 DXD motif; other site 536019008063 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019008064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008065 S-adenosylmethionine binding site [chemical binding]; other site 536019008066 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019008067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008068 S-adenosylmethionine binding site [chemical binding]; other site 536019008069 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 536019008070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019008071 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 536019008072 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019008073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019008074 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019008075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008076 S-adenosylmethionine binding site [chemical binding]; other site 536019008077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 536019008078 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 536019008079 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 536019008080 Walker A/P-loop; other site 536019008081 ATP binding site [chemical binding]; other site 536019008082 Q-loop/lid; other site 536019008083 ABC transporter signature motif; other site 536019008084 Walker B; other site 536019008085 D-loop; other site 536019008086 H-loop/switch region; other site 536019008087 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 536019008088 putative carbohydrate binding site [chemical binding]; other site 536019008089 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 536019008090 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 536019008091 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 536019008092 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 536019008093 NADP-binding site; other site 536019008094 homotetramer interface [polypeptide binding]; other site 536019008095 substrate binding site [chemical binding]; other site 536019008096 homodimer interface [polypeptide binding]; other site 536019008097 active site 536019008098 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 536019008099 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 536019008100 NADP-binding site; other site 536019008101 homotetramer interface [polypeptide binding]; other site 536019008102 substrate binding site [chemical binding]; other site 536019008103 homodimer interface [polypeptide binding]; other site 536019008104 active site 536019008105 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019008106 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019008107 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019008108 ligand binding site [chemical binding]; other site 536019008109 flexible hinge region; other site 536019008110 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 536019008111 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019008112 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019008113 metal binding site [ion binding]; metal-binding site 536019008114 active site 536019008115 I-site; other site 536019008116 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 536019008117 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019008118 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019008119 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019008120 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019008121 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019008122 catalytic residue [active] 536019008123 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 536019008124 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 536019008125 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019008126 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 536019008127 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 536019008128 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019008129 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019008130 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 536019008131 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 536019008132 putative active site [active] 536019008133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019008134 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 536019008135 Walker A/P-loop; other site 536019008136 ATP binding site [chemical binding]; other site 536019008137 Q-loop/lid; other site 536019008138 ABC transporter signature motif; other site 536019008139 Walker B; other site 536019008140 D-loop; other site 536019008141 H-loop/switch region; other site 536019008142 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 536019008143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019008144 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019008145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 536019008146 active site 536019008147 phosphorylation site [posttranslational modification] 536019008148 intermolecular recognition site; other site 536019008149 dimerization interface [polypeptide binding]; other site 536019008150 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 536019008151 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019008152 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019008153 TadE-like protein; Region: TadE; pfam07811 536019008154 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 536019008155 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 536019008156 BON domain; Region: BON; pfam04972 536019008157 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 536019008158 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 536019008159 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 536019008160 Flp/Fap pilin component; Region: Flp_Fap; cl01585 536019008161 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 536019008162 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 536019008163 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019008164 ATP binding site [chemical binding]; other site 536019008165 Walker A motif; other site 536019008166 hexamer interface [polypeptide binding]; other site 536019008167 Walker B motif; other site 536019008168 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 536019008169 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019008170 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 536019008171 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019008172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019008173 TPR motif; other site 536019008174 binding surface 536019008175 TPR repeat; Region: TPR_11; pfam13414 536019008176 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019008177 KTSC domain; Region: KTSC; pfam13619 536019008178 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 536019008179 mannonate dehydratase; Region: uxuA; TIGR00695 536019008180 classical (c) SDRs; Region: SDR_c; cd05233 536019008181 NAD(P) binding site [chemical binding]; other site 536019008182 active site 536019008183 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019008184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008185 DNA-binding site [nucleotide binding]; DNA binding site 536019008186 FCD domain; Region: FCD; pfam07729 536019008187 mannonate dehydratase; Provisional; Region: PRK03906 536019008188 mannonate dehydratase; Region: uxuA; TIGR00695 536019008189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019008190 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 536019008191 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536019008192 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019008193 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019008194 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019008195 ligand binding site [chemical binding]; other site 536019008196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008198 TM-ABC transporter signature motif; other site 536019008199 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019008200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019008201 Walker A/P-loop; other site 536019008202 ATP binding site [chemical binding]; other site 536019008203 Q-loop/lid; other site 536019008204 ABC transporter signature motif; other site 536019008205 Walker B; other site 536019008206 D-loop; other site 536019008207 H-loop/switch region; other site 536019008208 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019008209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008210 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008211 TM-ABC transporter signature motif; other site 536019008212 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 536019008213 classical (c) SDRs; Region: SDR_c; cd05233 536019008214 NAD(P) binding site [chemical binding]; other site 536019008215 active site 536019008216 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019008217 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019008218 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 536019008219 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019008220 substrate binding site [chemical binding]; other site 536019008221 oxyanion hole (OAH) forming residues; other site 536019008222 trimer interface [polypeptide binding]; other site 536019008223 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 536019008224 active site 536019008225 catalytic residues [active] 536019008226 Coenzyme A transferase; Region: CoA_trans; cl17247 536019008227 Coenzyme A transferase; Region: CoA_trans; cl17247 536019008228 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 536019008229 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 536019008230 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019008231 inhibitor-cofactor binding pocket; inhibition site 536019008232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008233 catalytic residue [active] 536019008234 N-formylglutamate amidohydrolase; Region: FGase; cl01522 536019008235 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 536019008236 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019008237 Isochorismatase family; Region: Isochorismatase; pfam00857 536019008238 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019008239 catalytic triad [active] 536019008240 conserved cis-peptide bond; other site 536019008241 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019008242 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019008243 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019008244 putative active site [active] 536019008245 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019008246 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019008247 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019008248 TM-ABC transporter signature motif; other site 536019008249 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019008250 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019008251 Walker A/P-loop; other site 536019008252 ATP binding site [chemical binding]; other site 536019008253 Q-loop/lid; other site 536019008254 ABC transporter signature motif; other site 536019008255 Walker B; other site 536019008256 D-loop; other site 536019008257 H-loop/switch region; other site 536019008258 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019008259 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019008260 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019008261 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019008262 Walker A/P-loop; other site 536019008263 ATP binding site [chemical binding]; other site 536019008264 Q-loop/lid; other site 536019008265 ABC transporter signature motif; other site 536019008266 Walker B; other site 536019008267 D-loop; other site 536019008268 H-loop/switch region; other site 536019008269 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019008270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008271 TM-ABC transporter signature motif; other site 536019008272 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 536019008273 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 536019008274 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 536019008275 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 536019008276 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 536019008277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019008278 NAD(P) binding site [chemical binding]; other site 536019008279 active site 536019008280 Protein of unknown function (DUF768); Region: DUF768; pfam05589 536019008281 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 536019008282 homodimer interface [polypeptide binding]; other site 536019008283 homotetramer interface [polypeptide binding]; other site 536019008284 active site pocket [active] 536019008285 cleavage site 536019008286 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 536019008287 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 536019008288 generic binding surface II; other site 536019008289 generic binding surface I; other site 536019008290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019008291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019008293 dimerization interface [polypeptide binding]; other site 536019008294 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019008295 Uncharacterized conserved protein [Function unknown]; Region: COG5403 536019008296 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 536019008297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 536019008298 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 536019008299 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 536019008300 catalytic triad [active] 536019008301 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019008302 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 536019008303 active site 536019008304 metal binding site [ion binding]; metal-binding site 536019008305 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 536019008306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536019008307 phosphate binding site [ion binding]; other site 536019008308 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019008309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008310 DNA-binding site [nucleotide binding]; DNA binding site 536019008311 FCD domain; Region: FCD; pfam07729 536019008312 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 536019008313 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 536019008314 FAD binding domain; Region: FAD_binding_4; pfam01565 536019008315 FAD binding domain; Region: FAD_binding_4; pfam01565 536019008316 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 536019008317 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 536019008318 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536019008319 Cysteine-rich domain; Region: CCG; pfam02754 536019008320 Cysteine-rich domain; Region: CCG; pfam02754 536019008321 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 536019008322 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 536019008323 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 536019008324 homodimer interface [polypeptide binding]; other site 536019008325 NADP binding site [chemical binding]; other site 536019008326 substrate binding site [chemical binding]; other site 536019008327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019008328 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019008329 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 536019008330 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 536019008331 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 536019008332 dimer interface [polypeptide binding]; other site 536019008333 motif 1; other site 536019008334 motif 2; other site 536019008335 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019008336 active site 536019008337 motif 3; other site 536019008338 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 536019008339 anticodon binding site; other site 536019008340 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 536019008341 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019008342 motif 1; other site 536019008343 dimer interface [polypeptide binding]; other site 536019008344 active site 536019008345 motif 2; other site 536019008346 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019008347 active site 536019008348 motif 3; other site 536019008349 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 536019008350 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 536019008351 AMP-binding domain protein; Validated; Region: PRK08315 536019008352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 536019008353 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 536019008354 acyl-activating enzyme (AAE) consensus motif; other site 536019008355 acyl-activating enzyme (AAE) consensus motif; other site 536019008356 putative AMP binding site [chemical binding]; other site 536019008357 putative active site [active] 536019008358 putative CoA binding site [chemical binding]; other site 536019008359 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 536019008360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019008361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008362 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019008363 putative effector binding pocket; other site 536019008364 putative dimerization interface [polypeptide binding]; other site 536019008365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008366 S-adenosylmethionine binding site [chemical binding]; other site 536019008367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019008368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019008369 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536019008370 active site 536019008371 tetramer interface [polypeptide binding]; other site 536019008372 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 536019008373 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 536019008374 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 536019008375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019008376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019008377 substrate binding pocket [chemical binding]; other site 536019008378 membrane-bound complex binding site; other site 536019008379 hinge residues; other site 536019008380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019008381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008382 dimer interface [polypeptide binding]; other site 536019008383 conserved gate region; other site 536019008384 putative PBP binding loops; other site 536019008385 ABC-ATPase subunit interface; other site 536019008386 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019008387 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019008388 Walker A/P-loop; other site 536019008389 ATP binding site [chemical binding]; other site 536019008390 Q-loop/lid; other site 536019008391 ABC transporter signature motif; other site 536019008392 Walker B; other site 536019008393 D-loop; other site 536019008394 H-loop/switch region; other site 536019008395 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 536019008396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008397 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 536019008398 dimerization interface [polypeptide binding]; other site 536019008399 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 536019008400 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 536019008401 dimer interface [polypeptide binding]; other site 536019008402 active site 536019008403 heme binding site [chemical binding]; other site 536019008404 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 536019008405 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 536019008406 amphipathic channel; other site 536019008407 Asn-Pro-Ala signature motifs; other site 536019008408 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 536019008409 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 536019008410 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536019008411 CoenzymeA binding site [chemical binding]; other site 536019008412 subunit interaction site [polypeptide binding]; other site 536019008413 PHB binding site; other site 536019008414 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 536019008415 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 536019008416 GMP synthase; Reviewed; Region: guaA; PRK00074 536019008417 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 536019008418 AMP/PPi binding site [chemical binding]; other site 536019008419 candidate oxyanion hole; other site 536019008420 catalytic triad [active] 536019008421 potential glutamine specificity residues [chemical binding]; other site 536019008422 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 536019008423 ATP Binding subdomain [chemical binding]; other site 536019008424 Ligand Binding sites [chemical binding]; other site 536019008425 Dimerization subdomain; other site 536019008426 integrase; Provisional; Region: PRK09692 536019008427 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 536019008428 active site 536019008429 Int/Topo IB signature motif; other site 536019008430 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 536019008431 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 536019008432 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019008433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019008434 DNA binding residues [nucleotide binding] 536019008435 dimerization interface [polypeptide binding]; other site 536019008436 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 536019008437 Autoinducer synthetase; Region: Autoind_synth; cl17404 536019008438 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 536019008439 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 536019008440 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 536019008441 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 536019008442 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 536019008443 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 536019008444 Putative transposase; Region: Y2_Tnp; pfam04986 536019008445 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536019008446 Sel1-like repeats; Region: SEL1; smart00671 536019008447 Sel1-like repeats; Region: SEL1; smart00671 536019008448 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 536019008449 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 536019008450 Putative transposase; Region: Y2_Tnp; pfam04986 536019008451 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536019008452 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 536019008453 active site 536019008454 catalytic residues [active] 536019008455 DNA binding site [nucleotide binding] 536019008456 Int/Topo IB signature motif; other site 536019008457 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 536019008458 Catalytic site; other site 536019008459 hypothetical protein; Provisional; Region: PRK10040 536019008460 PBCV-specific basic adaptor domain; Region: PBCV_basic_adap; pfam08789 536019008461 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019008462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008463 DNA-binding site [nucleotide binding]; DNA binding site 536019008464 FCD domain; Region: FCD; pfam07729 536019008465 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 536019008466 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 536019008467 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 536019008468 DctM-like transporters; Region: DctM; pfam06808 536019008469 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 536019008470 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 536019008471 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 536019008472 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 536019008473 NAD(P) binding site [chemical binding]; other site 536019008474 shikimate binding site; other site 536019008475 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 536019008476 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 536019008477 inhibitor site; inhibition site 536019008478 active site 536019008479 dimer interface [polypeptide binding]; other site 536019008480 catalytic residue [active] 536019008481 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 536019008482 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019008483 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019008484 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019008485 putative active site [active] 536019008486 hypothetical protein; Provisional; Region: PRK07483 536019008487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019008488 inhibitor-cofactor binding pocket; inhibition site 536019008489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008490 catalytic residue [active] 536019008491 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 536019008492 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 536019008493 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 536019008494 DctM-like transporters; Region: DctM; pfam06808 536019008495 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 536019008496 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 536019008497 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019008498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019008499 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019008500 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 536019008501 Uncharacterized conserved protein [Function unknown]; Region: COG5419 536019008502 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 536019008503 active site 536019008504 catalytic triad [active] 536019008505 oxyanion hole [active] 536019008506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008508 TM-ABC transporter signature motif; other site 536019008509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008510 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008511 TM-ABC transporter signature motif; other site 536019008512 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019008513 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019008514 Walker A/P-loop; other site 536019008515 ATP binding site [chemical binding]; other site 536019008516 Q-loop/lid; other site 536019008517 ABC transporter signature motif; other site 536019008518 Walker B; other site 536019008519 D-loop; other site 536019008520 H-loop/switch region; other site 536019008521 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019008522 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019008523 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 536019008524 putative ligand binding site [chemical binding]; other site 536019008525 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 536019008526 active site 536019008527 catalytic triad [active] 536019008528 oxyanion hole [active] 536019008529 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019008530 putative switch regulator; other site 536019008531 non-specific DNA interactions [nucleotide binding]; other site 536019008532 DNA binding site [nucleotide binding] 536019008533 sequence specific DNA binding site [nucleotide binding]; other site 536019008534 putative cAMP binding site [chemical binding]; other site 536019008535 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019008536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019008537 Uncharacterized conserved protein [Function unknown]; Region: COG5489 536019008538 Helix-turn-helix domain; Region: HTH_17; pfam12728 536019008539 Replication initiator protein A; Region: RPA; cl17860 536019008540 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 536019008541 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 536019008542 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 536019008543 Protein of unknown function (DUF736); Region: DUF736; cl02303 536019008544 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019008545 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019008546 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019008547 catalytic residue [active] 536019008548 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 536019008549 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 536019008550 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 536019008551 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 536019008552 Walker A motif; other site 536019008553 ATP binding site [chemical binding]; other site 536019008554 Walker B motif; other site 536019008555 HipA N-terminal domain; Region: Couple_hipA; pfam13657 536019008556 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 536019008557 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536019008558 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536019008559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019008560 non-specific DNA binding site [nucleotide binding]; other site 536019008561 salt bridge; other site 536019008562 sequence-specific DNA binding site [nucleotide binding]; other site 536019008563 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 536019008564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019008565 substrate binding pocket [chemical binding]; other site 536019008566 membrane-bound complex binding site; other site 536019008567 hinge residues; other site 536019008568 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 536019008569 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 536019008570 Uncharacterized conserved protein [Function unknown]; Region: COG3777 536019008571 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 536019008572 active site 2 [active] 536019008573 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 536019008574 active site 2 [active] 536019008575 active site 1 [active] 536019008576 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019008577 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019008578 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 536019008579 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019008580 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019008581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 536019008582 active site 536019008583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019008584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008585 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 536019008586 putative dimerization interface [polypeptide binding]; other site 536019008587 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019008588 PYR/PP interface [polypeptide binding]; other site 536019008589 dimer interface [polypeptide binding]; other site 536019008590 TPP binding site [chemical binding]; other site 536019008591 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 536019008592 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 536019008593 TPP-binding site [chemical binding]; other site 536019008594 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019008595 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 536019008596 NAD(P) binding site [chemical binding]; other site 536019008597 catalytic residues [active] 536019008598 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 536019008599 classical (c) SDRs; Region: SDR_c; cd05233 536019008600 NAD(P) binding site [chemical binding]; other site 536019008601 active site 536019008602 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 536019008603 dimer interface [polypeptide binding]; other site 536019008604 substrate binding site [chemical binding]; other site 536019008605 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019008606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008607 DNA-binding site [nucleotide binding]; DNA binding site 536019008608 FCD domain; Region: FCD; pfam07729 536019008609 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019008610 aspartate aminotransferase; Provisional; Region: PRK05764 536019008611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019008612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008613 homodimer interface [polypeptide binding]; other site 536019008614 catalytic residue [active] 536019008615 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 536019008616 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536019008617 carboxyltransferase (CT) interaction site; other site 536019008618 biotinylation site [posttranslational modification]; other site 536019008619 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 536019008620 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019008621 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 536019008622 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536019008623 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 536019008624 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 536019008625 lipoyl-biotinyl attachment site [posttranslational modification]; other site 536019008626 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 536019008627 putative active site [active] 536019008628 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 536019008629 Proline racemase; Region: Pro_racemase; pfam05544 536019008630 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 536019008631 Epoxide hydrolase N terminus; Region: EHN; pfam06441 536019008632 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019008633 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 536019008634 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 536019008635 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 536019008636 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 536019008637 classical (c) SDRs; Region: SDR_c; cd05233 536019008638 NAD(P) binding site [chemical binding]; other site 536019008639 active site 536019008640 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 536019008641 hypothetical protein; Validated; Region: PRK06201 536019008642 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019008643 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 536019008644 dimerization interface [polypeptide binding]; other site 536019008645 ligand binding site [chemical binding]; other site 536019008646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008647 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019008648 TM-ABC transporter signature motif; other site 536019008649 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019008650 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019008651 TM-ABC transporter signature motif; other site 536019008652 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019008653 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019008654 Walker A/P-loop; other site 536019008655 ATP binding site [chemical binding]; other site 536019008656 Q-loop/lid; other site 536019008657 ABC transporter signature motif; other site 536019008658 Walker B; other site 536019008659 D-loop; other site 536019008660 H-loop/switch region; other site 536019008661 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019008662 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019008663 Walker A/P-loop; other site 536019008664 ATP binding site [chemical binding]; other site 536019008665 Q-loop/lid; other site 536019008666 ABC transporter signature motif; other site 536019008667 Walker B; other site 536019008668 D-loop; other site 536019008669 H-loop/switch region; other site 536019008670 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019008671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019008672 putative DNA binding site [nucleotide binding]; other site 536019008673 putative Zn2+ binding site [ion binding]; other site 536019008674 AsnC family; Region: AsnC_trans_reg; pfam01037 536019008675 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 536019008676 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 536019008677 dimer interface [polypeptide binding]; other site 536019008678 TPP-binding site [chemical binding]; other site 536019008679 dimer interface [polypeptide binding]; other site 536019008680 PYR/PP interface [polypeptide binding]; other site 536019008681 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 536019008682 TPP binding site [chemical binding]; other site 536019008683 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 536019008684 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019008685 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019008686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008687 catalytic residue [active] 536019008688 dimer interface [polypeptide binding]; other site 536019008689 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 536019008690 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 536019008691 homodimer interface [polypeptide binding]; other site 536019008692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008693 catalytic residue [active] 536019008694 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 536019008695 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019008696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019008697 DNA binding residues [nucleotide binding] 536019008698 dimerization interface [polypeptide binding]; other site 536019008699 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 536019008700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019008701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019008702 DNA binding site [nucleotide binding] 536019008703 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019008704 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019008705 Walker A/P-loop; other site 536019008706 ATP binding site [chemical binding]; other site 536019008707 Q-loop/lid; other site 536019008708 ABC transporter signature motif; other site 536019008709 Walker B; other site 536019008710 D-loop; other site 536019008711 H-loop/switch region; other site 536019008712 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008714 dimer interface [polypeptide binding]; other site 536019008715 conserved gate region; other site 536019008716 putative PBP binding loops; other site 536019008717 ABC-ATPase subunit interface; other site 536019008718 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019008719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008720 dimer interface [polypeptide binding]; other site 536019008721 conserved gate region; other site 536019008722 putative PBP binding loops; other site 536019008723 ABC-ATPase subunit interface; other site 536019008724 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 536019008725 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019008726 ATP binding site [chemical binding]; other site 536019008727 Walker A motif; other site 536019008728 hexamer interface [polypeptide binding]; other site 536019008729 Walker B motif; other site 536019008730 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 536019008731 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 536019008732 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 536019008733 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 536019008734 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 536019008735 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 536019008736 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 536019008737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019008738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019008739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019008740 conjugal transfer protein TrbL; Provisional; Region: PRK13875 536019008741 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 536019008742 conjugal transfer protein TrbF; Provisional; Region: PRK13872 536019008743 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 536019008744 VirB7 interaction site; other site 536019008745 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 536019008746 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 536019008747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008748 S-adenosylmethionine binding site [chemical binding]; other site 536019008749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019008750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 536019008751 dimer interface [polypeptide binding]; other site 536019008752 phosphorylation site [posttranslational modification] 536019008753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019008754 ATP binding site [chemical binding]; other site 536019008755 Mg2+ binding site [ion binding]; other site 536019008756 G-X-G motif; other site 536019008757 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019008758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019008759 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019008760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019008761 S-adenosylmethionine binding site [chemical binding]; other site 536019008762 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536019008763 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 536019008764 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019008765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019008766 DNA-binding site [nucleotide binding]; DNA binding site 536019008767 FCD domain; Region: FCD; pfam07729 536019008768 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019008769 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019008770 active site pocket [active] 536019008771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019008772 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 536019008773 putative ligand binding site [chemical binding]; other site 536019008774 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008775 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008776 TM-ABC transporter signature motif; other site 536019008777 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019008778 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019008779 Walker A/P-loop; other site 536019008780 ATP binding site [chemical binding]; other site 536019008781 Q-loop/lid; other site 536019008782 ABC transporter signature motif; other site 536019008783 Walker B; other site 536019008784 D-loop; other site 536019008785 H-loop/switch region; other site 536019008786 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 536019008787 classical (c) SDRs; Region: SDR_c; cd05233 536019008788 NAD(P) binding site [chemical binding]; other site 536019008789 active site 536019008790 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 536019008791 active site 536019008792 catalytic residues [active] 536019008793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019008794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019008795 DNA binding site [nucleotide binding] 536019008796 domain linker motif; other site 536019008797 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 536019008798 ligand binding site [chemical binding]; other site 536019008799 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019008800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019008801 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019008802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019008803 Walker A/P-loop; other site 536019008804 ATP binding site [chemical binding]; other site 536019008805 Q-loop/lid; other site 536019008806 ABC transporter signature motif; other site 536019008807 Walker B; other site 536019008808 D-loop; other site 536019008809 H-loop/switch region; other site 536019008810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008811 dimer interface [polypeptide binding]; other site 536019008812 conserved gate region; other site 536019008813 putative PBP binding loops; other site 536019008814 ABC-ATPase subunit interface; other site 536019008815 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019008816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008817 dimer interface [polypeptide binding]; other site 536019008818 conserved gate region; other site 536019008819 putative PBP binding loops; other site 536019008820 ABC-ATPase subunit interface; other site 536019008821 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 536019008822 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 536019008823 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536019008824 Walker A/P-loop; other site 536019008825 ATP binding site [chemical binding]; other site 536019008826 Q-loop/lid; other site 536019008827 ABC transporter signature motif; other site 536019008828 Walker B; other site 536019008829 D-loop; other site 536019008830 H-loop/switch region; other site 536019008831 Heavy-metal resistance; Region: Metal_resist; pfam13801 536019008832 RNA polymerase sigma factor; Reviewed; Region: PRK05602 536019008833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019008834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019008835 DNA binding residues [nucleotide binding] 536019008836 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 536019008837 Ca2+ binding site [ion binding]; other site 536019008838 EF-hand domain pair; Region: EF_hand_5; pfam13499 536019008839 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 536019008840 Ca2+ binding site [ion binding]; other site 536019008841 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 536019008842 EF-hand domain pair; Region: EF_hand_5; pfam13499 536019008843 Ca2+ binding site [ion binding]; other site 536019008844 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 536019008845 Ca2+ binding site [ion binding]; other site 536019008846 BA14K-like protein; Region: BA14K; pfam07886 536019008847 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 536019008848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019008849 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 536019008850 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019008851 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019008852 Walker A/P-loop; other site 536019008853 ATP binding site [chemical binding]; other site 536019008854 Q-loop/lid; other site 536019008855 ABC transporter signature motif; other site 536019008856 Walker B; other site 536019008857 D-loop; other site 536019008858 H-loop/switch region; other site 536019008859 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019008860 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019008861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019008862 TM-ABC transporter signature motif; other site 536019008863 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 536019008864 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019008865 putative ligand binding site [chemical binding]; other site 536019008866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019008867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019008868 DNA binding site [nucleotide binding] 536019008869 domain linker motif; other site 536019008870 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 536019008871 putative dimerization interface [polypeptide binding]; other site 536019008872 putative ligand binding site [chemical binding]; other site 536019008873 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 536019008874 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 536019008875 putative NAD(P) binding site [chemical binding]; other site 536019008876 catalytic Zn binding site [ion binding]; other site 536019008877 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 536019008878 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 536019008879 putative ligand binding site [chemical binding]; other site 536019008880 NAD binding site [chemical binding]; other site 536019008881 catalytic site [active] 536019008882 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 536019008883 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 536019008884 NADP binding site [chemical binding]; other site 536019008885 homodimer interface [polypeptide binding]; other site 536019008886 active site 536019008887 AAA domain; Region: AAA_33; pfam13671 536019008888 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 536019008889 ATP-binding site [chemical binding]; other site 536019008890 Gluconate-6-phosphate binding site [chemical binding]; other site 536019008891 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019008892 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536019008893 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019008894 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019008895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019008896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008897 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 536019008898 putative dimerization interface [polypeptide binding]; other site 536019008899 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 536019008900 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 536019008901 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019008902 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 536019008903 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 536019008904 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019008905 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 536019008906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019008907 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019008908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019008909 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019008910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019008911 putative DNA binding site [nucleotide binding]; other site 536019008912 putative Zn2+ binding site [ion binding]; other site 536019008913 AsnC family; Region: AsnC_trans_reg; pfam01037 536019008914 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 536019008915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019008916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019008917 dimerization interface [polypeptide binding]; other site 536019008918 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 536019008919 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 536019008920 putative active site [active] 536019008921 putative FMN binding site [chemical binding]; other site 536019008922 putative catalytic residue [active] 536019008923 putative substrate binding site [chemical binding]; other site 536019008924 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019008925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019008926 putative DNA binding site [nucleotide binding]; other site 536019008927 putative Zn2+ binding site [ion binding]; other site 536019008928 AsnC family; Region: AsnC_trans_reg; pfam01037 536019008929 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 536019008930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019008931 Walker A/P-loop; other site 536019008932 ATP binding site [chemical binding]; other site 536019008933 Q-loop/lid; other site 536019008934 ABC transporter signature motif; other site 536019008935 Walker B; other site 536019008936 D-loop; other site 536019008937 H-loop/switch region; other site 536019008938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019008939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019008940 Walker A/P-loop; other site 536019008941 ATP binding site [chemical binding]; other site 536019008942 Q-loop/lid; other site 536019008943 ABC transporter signature motif; other site 536019008944 Walker B; other site 536019008945 D-loop; other site 536019008946 H-loop/switch region; other site 536019008947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019008948 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019008949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008950 dimer interface [polypeptide binding]; other site 536019008951 conserved gate region; other site 536019008952 ABC-ATPase subunit interface; other site 536019008953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019008954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019008955 dimer interface [polypeptide binding]; other site 536019008956 conserved gate region; other site 536019008957 putative PBP binding loops; other site 536019008958 ABC-ATPase subunit interface; other site 536019008959 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019008960 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019008961 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 536019008962 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 536019008963 hypothetical protein; Provisional; Region: PRK05965 536019008964 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019008965 inhibitor-cofactor binding pocket; inhibition site 536019008966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019008967 catalytic residue [active] 536019008968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536019008969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019008970 Coenzyme A binding pocket [chemical binding]; other site 536019008971 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 536019008972 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 536019008973 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019008974 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019008975 succinic semialdehyde dehydrogenase; Region: PLN02278 536019008976 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536019008977 tetramerization interface [polypeptide binding]; other site 536019008978 NAD(P) binding site [chemical binding]; other site 536019008979 catalytic residues [active] 536019008980 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 536019008981 tartrate dehydrogenase; Region: TTC; TIGR02089 536019008982 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019008983 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019008984 NAD(P) binding site [chemical binding]; other site 536019008985 catalytic residues [active] 536019008986 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019008987 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019008988 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 536019008989 putative ligand binding site [chemical binding]; other site 536019008990 NAD binding site [chemical binding]; other site 536019008991 dimerization interface [polypeptide binding]; other site 536019008992 catalytic site [active] 536019008993 acetylornithine deacetylase; Provisional; Region: PRK07522 536019008994 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 536019008995 metal binding site [ion binding]; metal-binding site 536019008996 putative dimer interface [polypeptide binding]; other site 536019008997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019008998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019008999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009000 dimer interface [polypeptide binding]; other site 536019009001 conserved gate region; other site 536019009002 putative PBP binding loops; other site 536019009003 ABC-ATPase subunit interface; other site 536019009004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019009005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009006 dimer interface [polypeptide binding]; other site 536019009007 conserved gate region; other site 536019009008 putative PBP binding loops; other site 536019009009 ABC-ATPase subunit interface; other site 536019009010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019009011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019009012 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019009013 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019009014 Walker A/P-loop; other site 536019009015 ATP binding site [chemical binding]; other site 536019009016 Q-loop/lid; other site 536019009017 ABC transporter signature motif; other site 536019009018 Walker B; other site 536019009019 D-loop; other site 536019009020 H-loop/switch region; other site 536019009021 TOBE domain; Region: TOBE_2; pfam08402 536019009022 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 536019009023 tartrate dehydrogenase; Region: TTC; TIGR02089 536019009024 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 536019009025 PAS fold; Region: PAS_7; pfam12860 536019009026 PAS fold; Region: PAS_4; pfam08448 536019009027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019009028 putative active site [active] 536019009029 heme pocket [chemical binding]; other site 536019009030 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019009031 GAF domain; Region: GAF; pfam01590 536019009032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019009033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019009034 metal binding site [ion binding]; metal-binding site 536019009035 active site 536019009036 I-site; other site 536019009037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019009038 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 536019009039 Uncharacterized conserved protein [Function unknown]; Region: COG5654 536019009040 CHASE4 domain; Region: CHASE4; pfam05228 536019009041 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019009042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019009043 metal binding site [ion binding]; metal-binding site 536019009044 active site 536019009045 I-site; other site 536019009046 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019009047 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 536019009048 active site 536019009049 DNA binding site [nucleotide binding] 536019009050 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 536019009051 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 536019009052 DNA binding site [nucleotide binding] 536019009053 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 536019009054 nucleotide binding site [chemical binding]; other site 536019009055 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 536019009056 homodimer interface [polypeptide binding]; other site 536019009057 putative GKAP docking site [polypeptide binding]; other site 536019009058 RepB plasmid partitioning protein; Region: RepB; pfam07506 536019009059 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 536019009060 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 536019009061 catalytic residues [active] 536019009062 catalytic nucleophile [active] 536019009063 Recombinase; Region: Recombinase; pfam07508 536019009064 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 536019009065 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019009066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009067 S-adenosylmethionine binding site [chemical binding]; other site 536019009068 Methyltransferase domain; Region: Methyltransf_24; pfam13578 536019009069 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 536019009070 Uncharacterized conserved protein [Function unknown]; Region: COG5654 536019009071 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019009072 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019009073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019009074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019009075 ligand binding site [chemical binding]; other site 536019009076 flexible hinge region; other site 536019009077 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 536019009078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019009079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019009080 DNA binding residues [nucleotide binding] 536019009081 dimerization interface [polypeptide binding]; other site 536019009082 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 536019009083 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 536019009084 Substrate binding site; other site 536019009085 Cupin domain; Region: Cupin_2; cl17218 536019009086 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 536019009087 dimerization interface [polypeptide binding]; other site 536019009088 putative active cleft [active] 536019009089 Chain length determinant protein; Region: Wzz; cl15801 536019009090 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 536019009091 Bacterial sugar transferase; Region: Bac_transf; pfam02397 536019009092 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 536019009093 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536019009094 SLBB domain; Region: SLBB; pfam10531 536019009095 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 536019009096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019009097 putative ADP-binding pocket [chemical binding]; other site 536019009098 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019009099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009100 S-adenosylmethionine binding site [chemical binding]; other site 536019009101 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 536019009102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019009103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019009104 active site 536019009105 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019009106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009107 S-adenosylmethionine binding site [chemical binding]; other site 536019009108 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 536019009109 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 536019009110 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019009111 Methyltransferase domain; Region: Methyltransf_12; pfam08242 536019009112 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 536019009113 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019009114 extended (e) SDRs; Region: SDR_e; cd08946 536019009115 NAD(P) binding site [chemical binding]; other site 536019009116 active site 536019009117 substrate binding site [chemical binding]; other site 536019009118 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 536019009119 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 536019009120 substrate binding site; other site 536019009121 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 536019009122 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 536019009123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019009124 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019009125 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536019009126 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 536019009127 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 536019009128 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 536019009129 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 536019009130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019009131 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 536019009132 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 536019009133 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 536019009134 active site 536019009135 substrate binding site [chemical binding]; other site 536019009136 metal binding site [ion binding]; metal-binding site 536019009137 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 536019009138 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 536019009139 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019009140 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019009141 putative NAD(P) binding site [chemical binding]; other site 536019009142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019009143 classical (c) SDRs; Region: SDR_c; cd05233 536019009144 NAD(P) binding site [chemical binding]; other site 536019009145 active site 536019009146 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 536019009147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019009148 inhibitor-cofactor binding pocket; inhibition site 536019009149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019009150 catalytic residue [active] 536019009151 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 536019009152 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 536019009153 active site 536019009154 substrate binding site [chemical binding]; other site 536019009155 ATP binding site [chemical binding]; other site 536019009156 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 536019009157 substrate binding site [chemical binding]; other site 536019009158 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 536019009159 classical (c) SDRs; Region: SDR_c; cd05233 536019009160 NAD(P) binding site [chemical binding]; other site 536019009161 active site 536019009162 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 536019009163 Isochorismatase family; Region: Isochorismatase; pfam00857 536019009164 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019009165 catalytic triad [active] 536019009166 conserved cis-peptide bond; other site 536019009167 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 536019009168 Dehydratase large subunit; Region: Dehydratase_LU; pfam02286 536019009169 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 536019009170 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 536019009171 alpha-beta subunit interface [polypeptide binding]; other site 536019009172 alpha-gamma subunit interface [polypeptide binding]; other site 536019009173 active site 536019009174 substrate and K+ binding site; other site 536019009175 K+ binding site [ion binding]; other site 536019009176 cobalamin binding site [chemical binding]; other site 536019009177 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 536019009178 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 536019009179 substrate binding site [chemical binding]; other site 536019009180 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 536019009181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009182 S-adenosylmethionine binding site [chemical binding]; other site 536019009183 Erythromycin esterase; Region: Erythro_esteras; pfam05139 536019009184 putative phosphoketolase; Provisional; Region: PRK05261 536019009185 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 536019009186 TPP-binding site; other site 536019009187 XFP C-terminal domain; Region: XFP_C; pfam09363 536019009188 Acetokinase family; Region: Acetate_kinase; cl17229 536019009189 propionate/acetate kinase; Provisional; Region: PRK12379 536019009190 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 536019009191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019009192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019009193 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019009194 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 536019009195 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 536019009196 malonyl-CoA binding site [chemical binding]; other site 536019009197 dimer interface [polypeptide binding]; other site 536019009198 active site 536019009199 product binding site; other site 536019009200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009201 S-adenosylmethionine binding site [chemical binding]; other site 536019009202 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 536019009203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019009204 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536019009205 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 536019009206 tetramer interface [polypeptide binding]; other site 536019009207 active site 536019009208 Mg2+/Mn2+ binding site [ion binding]; other site 536019009209 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 536019009210 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 536019009211 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 536019009212 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019009213 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 536019009214 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 536019009215 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019009216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019009217 ligand binding site [chemical binding]; other site 536019009218 flexible hinge region; other site 536019009219 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019009220 non-specific DNA interactions [nucleotide binding]; other site 536019009221 DNA binding site [nucleotide binding] 536019009222 sequence specific DNA binding site [nucleotide binding]; other site 536019009223 putative cAMP binding site [chemical binding]; other site 536019009224 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 536019009225 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 536019009226 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019009227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 536019009228 HD domain; Region: HD_4; pfam13328 536019009229 Isochorismatase family; Region: Isochorismatase; pfam00857 536019009230 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019009231 catalytic triad [active] 536019009232 conserved cis-peptide bond; other site 536019009233 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 536019009234 trimer interface [polypeptide binding]; other site 536019009235 putative Zn binding site [ion binding]; other site 536019009236 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019009237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019009238 catalytic loop [active] 536019009239 iron binding site [ion binding]; other site 536019009240 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019009241 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019009242 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 536019009243 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019009244 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019009245 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019009246 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 536019009247 dimerization interface [polypeptide binding]; other site 536019009248 metal binding site [ion binding]; metal-binding site 536019009249 short chain dehydrogenase; Provisional; Region: PRK06701 536019009250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019009251 NAD(P) binding site [chemical binding]; other site 536019009252 active site 536019009253 ornithine cyclodeaminase; Validated; Region: PRK07589 536019009254 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 536019009255 Arginase family; Region: Arginase; cd09989 536019009256 active site 536019009257 Mn binding site [ion binding]; other site 536019009258 oligomer interface [polypeptide binding]; other site 536019009259 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019009260 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 536019009261 AsnC family; Region: AsnC_trans_reg; pfam01037 536019009262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 536019009263 Sterol carrier protein domain; Region: SCP2_2; pfam13530 536019009264 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019009265 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019009266 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019009267 putative active site [active] 536019009268 N-acetylmannosamine kinase; Provisional; Region: PRK05082 536019009269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536019009270 nucleotide binding site [chemical binding]; other site 536019009271 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 536019009272 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 536019009273 putative active site cavity [active] 536019009274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019009275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019009276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019009277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019009278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019009279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009280 dimer interface [polypeptide binding]; other site 536019009281 conserved gate region; other site 536019009282 putative PBP binding loops; other site 536019009283 ABC-ATPase subunit interface; other site 536019009284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019009285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009286 dimer interface [polypeptide binding]; other site 536019009287 conserved gate region; other site 536019009288 putative PBP binding loops; other site 536019009289 ABC-ATPase subunit interface; other site 536019009290 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019009291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019009292 Walker A/P-loop; other site 536019009293 ATP binding site [chemical binding]; other site 536019009294 Q-loop/lid; other site 536019009295 ABC transporter signature motif; other site 536019009296 Walker B; other site 536019009297 D-loop; other site 536019009298 H-loop/switch region; other site 536019009299 TOBE domain; Region: TOBE_2; pfam08402 536019009300 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019009301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019009302 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 536019009303 active site 536019009304 catalytic residues [active] 536019009305 metal binding site [ion binding]; metal-binding site 536019009306 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019009307 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019009308 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 536019009309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 536019009310 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 536019009311 amidase; Validated; Region: PRK06565 536019009312 Amidase; Region: Amidase; cl11426 536019009313 Amidase; Region: Amidase; cl11426 536019009314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019009315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019009316 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019009317 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019009318 Walker A/P-loop; other site 536019009319 ATP binding site [chemical binding]; other site 536019009320 Q-loop/lid; other site 536019009321 ABC transporter signature motif; other site 536019009322 Walker B; other site 536019009323 D-loop; other site 536019009324 H-loop/switch region; other site 536019009325 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019009326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009327 TM-ABC transporter signature motif; other site 536019009328 D-allose transporter subunit; Provisional; Region: PRK09701 536019009329 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019009330 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 536019009331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019009332 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 536019009333 active site 536019009334 choline dehydrogenase; Validated; Region: PRK02106 536019009335 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 536019009336 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019009337 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019009338 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019009339 NAD(P) binding site [chemical binding]; other site 536019009340 catalytic residues [active] 536019009341 Uncharacterized conserved protein [Function unknown]; Region: COG2353 536019009342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019009343 classical (c) SDRs; Region: SDR_c; cd05233 536019009344 NAD(P) binding site [chemical binding]; other site 536019009345 active site 536019009346 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 536019009347 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 536019009348 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019009349 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019009350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019009351 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019009352 Walker A/P-loop; other site 536019009353 ATP binding site [chemical binding]; other site 536019009354 Q-loop/lid; other site 536019009355 ABC transporter signature motif; other site 536019009356 Walker B; other site 536019009357 D-loop; other site 536019009358 H-loop/switch region; other site 536019009359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019009360 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019009361 Walker A/P-loop; other site 536019009362 ATP binding site [chemical binding]; other site 536019009363 Q-loop/lid; other site 536019009364 ABC transporter signature motif; other site 536019009365 Walker B; other site 536019009366 D-loop; other site 536019009367 H-loop/switch region; other site 536019009368 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019009369 TM-ABC transporter signature motif; other site 536019009370 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009371 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019009372 TM-ABC transporter signature motif; other site 536019009373 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019009374 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019009375 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019009376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009377 dimer interface [polypeptide binding]; other site 536019009378 conserved gate region; other site 536019009379 putative PBP binding loops; other site 536019009380 ABC-ATPase subunit interface; other site 536019009381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019009382 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019009383 Walker A/P-loop; other site 536019009384 ATP binding site [chemical binding]; other site 536019009385 Q-loop/lid; other site 536019009386 ABC transporter signature motif; other site 536019009387 Walker B; other site 536019009388 D-loop; other site 536019009389 H-loop/switch region; other site 536019009390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019009391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019009392 DNA binding site [nucleotide binding] 536019009393 domain linker motif; other site 536019009394 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019009395 dimerization interface [polypeptide binding]; other site 536019009396 ligand binding site [chemical binding]; other site 536019009397 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 536019009398 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 536019009399 metal binding site [ion binding]; metal-binding site 536019009400 putative dimer interface [polypeptide binding]; other site 536019009401 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 536019009402 putative hydrophobic ligand binding site [chemical binding]; other site 536019009403 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019009404 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536019009405 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019009406 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019009407 catalytic loop [active] 536019009408 iron binding site [ion binding]; other site 536019009409 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019009410 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019009411 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019009412 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019009413 Ubiquitin-like proteins; Region: UBQ; cl00155 536019009414 charged pocket; other site 536019009415 hydrophobic patch; other site 536019009416 Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DodA; COG3805 536019009417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009418 S-adenosylmethionine binding site [chemical binding]; other site 536019009419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019009420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019009421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 536019009422 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 536019009423 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019009424 Ligand Binding Site [chemical binding]; other site 536019009425 Uncharacterized conserved protein [Function unknown]; Region: COG1415 536019009426 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 536019009427 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019009428 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 536019009429 putative dimer interface [polypeptide binding]; other site 536019009430 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 536019009431 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536019009432 putative active site pocket [active] 536019009433 dimerization interface [polypeptide binding]; other site 536019009434 putative catalytic residue [active] 536019009435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019009436 dimerization interface [polypeptide binding]; other site 536019009437 putative DNA binding site [nucleotide binding]; other site 536019009438 putative Zn2+ binding site [ion binding]; other site 536019009439 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 536019009440 putative hydrophobic ligand binding site [chemical binding]; other site 536019009441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019009442 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 536019009443 Uncharacterized conserved protein [Function unknown]; Region: COG5649 536019009444 Uncharacterized conserved protein [Function unknown]; Region: COG5649 536019009445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 536019009446 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 536019009447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019009448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009449 dimer interface [polypeptide binding]; other site 536019009450 conserved gate region; other site 536019009451 putative PBP binding loops; other site 536019009452 ABC-ATPase subunit interface; other site 536019009453 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 536019009454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009455 putative PBP binding loops; other site 536019009456 ABC-ATPase subunit interface; other site 536019009457 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019009458 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019009459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019009460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019009461 DNA binding site [nucleotide binding] 536019009462 domain linker motif; other site 536019009463 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019009464 dimerization interface [polypeptide binding]; other site 536019009465 ligand binding site [chemical binding]; other site 536019009466 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 536019009467 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 536019009468 oligomerisation interface [polypeptide binding]; other site 536019009469 mobile loop; other site 536019009470 roof hairpin; other site 536019009471 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 536019009472 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 536019009473 ring oligomerisation interface [polypeptide binding]; other site 536019009474 ATP/Mg binding site [chemical binding]; other site 536019009475 stacking interactions; other site 536019009476 hinge regions; other site 536019009477 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 536019009478 Predicted membrane protein [Function unknown]; Region: COG2855 536019009479 Predicted ester cyclase [General function prediction only]; Region: COG5485 536019009480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009482 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019009483 putative effector binding pocket; other site 536019009484 putative dimerization interface [polypeptide binding]; other site 536019009485 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019009486 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 536019009487 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 536019009488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019009489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019009490 active site 536019009491 catalytic tetrad [active] 536019009492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536019009493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019009494 Coenzyme A binding pocket [chemical binding]; other site 536019009495 Uncharacterized conserved protein [Function unknown]; Region: COG3603 536019009496 Family description; Region: ACT_7; pfam13840 536019009497 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 536019009498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019009499 NAD binding site [chemical binding]; other site 536019009500 catalytic residues [active] 536019009501 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 536019009502 RES domain; Region: RES; smart00953 536019009503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019009504 dimerization interface [polypeptide binding]; other site 536019009505 putative DNA binding site [nucleotide binding]; other site 536019009506 putative Zn2+ binding site [ion binding]; other site 536019009507 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 536019009508 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 536019009509 FMN binding site [chemical binding]; other site 536019009510 active site 536019009511 substrate binding site [chemical binding]; other site 536019009512 catalytic residue [active] 536019009513 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019009514 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019009515 Walker A/P-loop; other site 536019009516 ATP binding site [chemical binding]; other site 536019009517 Q-loop/lid; other site 536019009518 ABC transporter signature motif; other site 536019009519 Walker B; other site 536019009520 D-loop; other site 536019009521 H-loop/switch region; other site 536019009522 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019009523 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 536019009524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009525 putative PBP binding loops; other site 536019009526 dimer interface [polypeptide binding]; other site 536019009527 ABC-ATPase subunit interface; other site 536019009528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019009529 dimer interface [polypeptide binding]; other site 536019009530 conserved gate region; other site 536019009531 putative PBP binding loops; other site 536019009532 ABC-ATPase subunit interface; other site 536019009533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019009534 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019009535 substrate binding pocket [chemical binding]; other site 536019009536 membrane-bound complex binding site; other site 536019009537 hinge residues; other site 536019009538 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 536019009539 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 536019009540 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019009541 AsnC family; Region: AsnC_trans_reg; pfam01037 536019009542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019009545 dimerization interface [polypeptide binding]; other site 536019009546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019009547 Coenzyme A binding pocket [chemical binding]; other site 536019009548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 536019009549 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019009550 Ligand Binding Site [chemical binding]; other site 536019009551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019009552 catalytic core [active] 536019009553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019009554 active site 536019009555 metal binding site [ion binding]; metal-binding site 536019009556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019009557 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 536019009558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019009559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019009560 DNA binding residues [nucleotide binding] 536019009561 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 536019009562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019009563 NAD(P) binding site [chemical binding]; other site 536019009564 active site 536019009565 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 536019009566 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 536019009567 active site 536019009568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019009569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019009570 active site 536019009571 catalytic tetrad [active] 536019009572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009574 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019009575 putative effector binding pocket; other site 536019009576 putative dimerization interface [polypeptide binding]; other site 536019009577 PAS fold; Region: PAS_4; pfam08448 536019009578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019009579 putative active site [active] 536019009580 heme pocket [chemical binding]; other site 536019009581 PAS fold; Region: PAS_7; pfam12860 536019009582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019009583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019009584 metal binding site [ion binding]; metal-binding site 536019009585 active site 536019009586 I-site; other site 536019009587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019009588 salt bridge; other site 536019009589 non-specific DNA binding site [nucleotide binding]; other site 536019009590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019009591 sequence-specific DNA binding site [nucleotide binding]; other site 536019009592 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019009593 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 536019009594 putative NAD(P) binding site [chemical binding]; other site 536019009595 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 536019009596 RibD C-terminal domain; Region: RibD_C; cl17279 536019009597 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019009598 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019009599 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019009600 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019009601 Walker A/P-loop; other site 536019009602 ATP binding site [chemical binding]; other site 536019009603 Q-loop/lid; other site 536019009604 ABC transporter signature motif; other site 536019009605 Walker B; other site 536019009606 D-loop; other site 536019009607 H-loop/switch region; other site 536019009608 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019009609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009610 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019009611 TM-ABC transporter signature motif; other site 536019009612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019009613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019009614 non-specific DNA binding site [nucleotide binding]; other site 536019009615 salt bridge; other site 536019009616 sequence-specific DNA binding site [nucleotide binding]; other site 536019009617 Predicted transcriptional regulator [Transcription]; Region: COG2932 536019009618 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536019009619 Catalytic site [active] 536019009620 GcrA cell cycle regulator; Region: GcrA; cl11564 536019009621 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019009622 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019009623 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019009624 Predicted membrane protein [Function unknown]; Region: COG5395 536019009625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019009626 short chain dehydrogenase; Provisional; Region: PRK06179 536019009627 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536019009628 NADP binding site [chemical binding]; other site 536019009629 active site 536019009630 steroid binding site; other site 536019009631 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019009632 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 536019009633 putative NAD(P) binding site [chemical binding]; other site 536019009634 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019009635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019009636 DNA-binding site [nucleotide binding]; DNA binding site 536019009637 FCD domain; Region: FCD; pfam07729 536019009638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019009639 sequence-specific DNA binding site [nucleotide binding]; other site 536019009640 salt bridge; other site 536019009641 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 536019009642 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019009643 putative ligand binding site [chemical binding]; other site 536019009644 putative NAD binding site [chemical binding]; other site 536019009645 catalytic site [active] 536019009646 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019009647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019009648 DNA binding site [nucleotide binding] 536019009649 domain linker motif; other site 536019009650 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019009651 dimerization interface [polypeptide binding]; other site 536019009652 ligand binding site [chemical binding]; other site 536019009653 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019009654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 536019009655 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019009656 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 536019009657 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 536019009658 Chain length determinant protein; Region: Wzz; cl15801 536019009659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 536019009660 O-Antigen ligase; Region: Wzy_C; pfam04932 536019009661 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 536019009662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019009663 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 536019009664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019009665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019009666 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019009667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019009668 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019009669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019009670 conserved hypothetical protein; Region: TIGR02118 536019009671 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 536019009672 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 536019009673 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 536019009674 active site 536019009675 DNA binding site [nucleotide binding] 536019009676 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 536019009677 DNA binding site [nucleotide binding] 536019009678 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 536019009679 nucleotide binding site [chemical binding]; other site 536019009680 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 536019009681 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 536019009682 putative DNA binding site [nucleotide binding]; other site 536019009683 putative homodimer interface [polypeptide binding]; other site 536019009684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019009685 TPR repeat; Region: TPR_11; pfam13414 536019009686 TPR motif; other site 536019009687 TPR repeat; Region: TPR_11; pfam13414 536019009688 binding surface 536019009689 TPR repeat; Region: TPR_11; pfam13414 536019009690 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 536019009691 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 536019009692 putative catalytic site [active] 536019009693 putative phosphate binding site [ion binding]; other site 536019009694 active site 536019009695 metal binding site A [ion binding]; metal-binding site 536019009696 DNA binding site [nucleotide binding] 536019009697 putative AP binding site [nucleotide binding]; other site 536019009698 putative metal binding site B [ion binding]; other site 536019009699 FOG: WD40 repeat [General function prediction only]; Region: COG2319 536019009700 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 536019009701 structural tetrad; other site 536019009702 glutamate-tRNA ligase; Region: PLN02907 536019009703 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 536019009704 putative S-transferase; Provisional; Region: PRK11752 536019009705 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 536019009706 C-terminal domain interface [polypeptide binding]; other site 536019009707 GSH binding site (G-site) [chemical binding]; other site 536019009708 dimer interface [polypeptide binding]; other site 536019009709 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 536019009710 dimer interface [polypeptide binding]; other site 536019009711 N-terminal domain interface [polypeptide binding]; other site 536019009712 active site 536019009713 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 536019009714 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019009715 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019009716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536019009719 dimerization interface [polypeptide binding]; other site 536019009720 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 536019009721 short chain dehydrogenase; Provisional; Region: PRK07041 536019009722 putative NAD(P) binding site [chemical binding]; other site 536019009723 homodimer interface [polypeptide binding]; other site 536019009724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019009725 active site 536019009726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 536019009727 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 536019009728 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019009729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019009730 substrate binding pocket [chemical binding]; other site 536019009731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019009732 membrane-bound complex binding site; other site 536019009733 hinge residues; other site 536019009734 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 536019009735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019009736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019009737 Walker A/P-loop; other site 536019009738 ATP binding site [chemical binding]; other site 536019009739 Q-loop/lid; other site 536019009740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019009741 ABC transporter signature motif; other site 536019009742 Walker B; other site 536019009743 D-loop; other site 536019009744 ABC transporter; Region: ABC_tran_2; pfam12848 536019009745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019009746 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 536019009747 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 536019009748 putative C-terminal domain interface [polypeptide binding]; other site 536019009749 putative GSH binding site (G-site) [chemical binding]; other site 536019009750 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019009751 putative dimer interface [polypeptide binding]; other site 536019009752 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 536019009753 dimer interface [polypeptide binding]; other site 536019009754 N-terminal domain interface [polypeptide binding]; other site 536019009755 putative substrate binding pocket (H-site) [chemical binding]; other site 536019009756 hypothetical protein; Provisional; Region: PRK06834 536019009757 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019009758 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019009759 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 536019009760 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 536019009761 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019009762 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536019009763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019009764 S-adenosylmethionine binding site [chemical binding]; other site 536019009765 heat shock protein 90; Provisional; Region: PRK05218 536019009766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019009767 ATP binding site [chemical binding]; other site 536019009768 Mg2+ binding site [ion binding]; other site 536019009769 G-X-G motif; other site 536019009770 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 536019009771 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 536019009772 active site 536019009773 acyl-activating enzyme (AAE) consensus motif; other site 536019009774 putative CoA binding site [chemical binding]; other site 536019009775 AMP binding site [chemical binding]; other site 536019009776 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 536019009777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019009778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019009779 DNA binding site [nucleotide binding] 536019009780 domain linker motif; other site 536019009781 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 536019009782 putative dimerization interface [polypeptide binding]; other site 536019009783 putative ligand binding site [chemical binding]; other site 536019009784 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019009785 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 536019009786 active site 536019009787 dimerization interface [polypeptide binding]; other site 536019009788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 536019009791 putative effector binding pocket; other site 536019009792 putative dimerization interface [polypeptide binding]; other site 536019009793 short chain dehydrogenase; Provisional; Region: PRK12937 536019009794 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 536019009795 NADP binding site [chemical binding]; other site 536019009796 homodimer interface [polypeptide binding]; other site 536019009797 active site 536019009798 substrate binding site [chemical binding]; other site 536019009799 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 536019009800 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019009801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009802 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019009803 dimerization interface [polypeptide binding]; other site 536019009804 substrate binding pocket [chemical binding]; other site 536019009805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019009806 NmrA-like family; Region: NmrA; pfam05368 536019009807 NAD(P) binding site [chemical binding]; other site 536019009808 active site 536019009809 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 536019009810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019009811 FeS/SAM binding site; other site 536019009812 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 536019009813 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 536019009814 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 536019009815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019009816 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 536019009817 Coenzyme A binding pocket [chemical binding]; other site 536019009818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019009819 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 536019009820 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 536019009821 acyl-activating enzyme (AAE) consensus motif; other site 536019009822 AMP binding site [chemical binding]; other site 536019009823 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 536019009824 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 536019009825 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 536019009826 putative trimer interface [polypeptide binding]; other site 536019009827 putative CoA binding site [chemical binding]; other site 536019009828 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 536019009829 putative trimer interface [polypeptide binding]; other site 536019009830 putative CoA binding site [chemical binding]; other site 536019009831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019009832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019009833 TPR motif; other site 536019009834 TPR repeat; Region: TPR_11; pfam13414 536019009835 binding surface 536019009836 Predicted membrane protein [Function unknown]; Region: COG2259 536019009837 BA14K-like protein; Region: BA14K; pfam07886 536019009838 BA14K-like protein; Region: BA14K; pfam07886 536019009839 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 536019009840 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019009841 EamA-like transporter family; Region: EamA; pfam00892 536019009842 EamA-like transporter family; Region: EamA; pfam00892 536019009843 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 536019009844 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 536019009845 septum formation inhibitor; Reviewed; Region: minC; PRK05177 536019009846 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 536019009847 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 536019009848 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 536019009849 Switch I; other site 536019009850 Switch II; other site 536019009851 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 536019009852 HAMP domain; Region: HAMP; pfam00672 536019009853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019009854 dimer interface [polypeptide binding]; other site 536019009855 phosphorylation site [posttranslational modification] 536019009856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019009857 ATP binding site [chemical binding]; other site 536019009858 Mg2+ binding site [ion binding]; other site 536019009859 G-X-G motif; other site 536019009860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019009861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019009862 active site 536019009863 phosphorylation site [posttranslational modification] 536019009864 intermolecular recognition site; other site 536019009865 dimerization interface [polypeptide binding]; other site 536019009866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019009867 DNA binding site [nucleotide binding] 536019009868 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 536019009869 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019009870 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019009871 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 536019009872 Protein export membrane protein; Region: SecD_SecF; cl14618 536019009873 Protein export membrane protein; Region: SecD_SecF; cl14618 536019009874 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 536019009875 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 536019009876 EamA-like transporter family; Region: EamA; pfam00892 536019009877 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536019009878 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536019009879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019009880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019009881 PAS domain; Region: PAS; smart00091 536019009882 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 536019009883 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019009884 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019009885 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 536019009886 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 536019009887 dimer interface [polypeptide binding]; other site 536019009888 active site residues [active] 536019009889 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 536019009890 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 536019009891 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 536019009892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019009893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019009894 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019009895 putative effector binding pocket; other site 536019009896 dimerization interface [polypeptide binding]; other site 536019009897 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 536019009898 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019009899 putative NAD(P) binding site [chemical binding]; other site 536019009900 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019009901 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019009902 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019009903 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019009904 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 536019009905 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019009906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019009907 catalytic loop [active] 536019009908 iron binding site [ion binding]; other site 536019009909 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019009910 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019009911 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019009912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019009913 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019009914 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019009915 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019009916 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 536019009917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019009918 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019009919 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 536019009920 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019009921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019009922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019009923 Walker A/P-loop; other site 536019009924 ATP binding site [chemical binding]; other site 536019009925 Q-loop/lid; other site 536019009926 ABC transporter signature motif; other site 536019009927 Walker B; other site 536019009928 D-loop; other site 536019009929 H-loop/switch region; other site 536019009930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019009931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009932 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019009933 TM-ABC transporter signature motif; other site 536019009934 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 536019009935 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019009936 putative ligand binding site [chemical binding]; other site 536019009937 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 536019009938 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019009939 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 536019009940 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 536019009941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019009942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019009943 active site 536019009944 catalytic tetrad [active] 536019009945 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019009946 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536019009947 C-terminal domain interface [polypeptide binding]; other site 536019009948 GSH binding site (G-site) [chemical binding]; other site 536019009949 dimer interface [polypeptide binding]; other site 536019009950 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 536019009951 N-terminal domain interface [polypeptide binding]; other site 536019009952 HerA helicase [Replication, recombination, and repair]; Region: COG0433 536019009953 Usg-like family; Region: Usg; cl11567 536019009954 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 536019009955 oligomerisation interface [polypeptide binding]; other site 536019009956 mobile loop; other site 536019009957 roof hairpin; other site 536019009958 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 536019009959 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 536019009960 ring oligomerisation interface [polypeptide binding]; other site 536019009961 ATP/Mg binding site [chemical binding]; other site 536019009962 stacking interactions; other site 536019009963 hinge regions; other site 536019009964 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019009965 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 536019009966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019009968 TM-ABC transporter signature motif; other site 536019009969 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019009970 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019009971 TM-ABC transporter signature motif; other site 536019009972 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019009973 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019009974 Walker A/P-loop; other site 536019009975 ATP binding site [chemical binding]; other site 536019009976 Q-loop/lid; other site 536019009977 ABC transporter signature motif; other site 536019009978 Walker B; other site 536019009979 D-loop; other site 536019009980 H-loop/switch region; other site 536019009981 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019009982 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 536019009983 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019009984 putative ligand binding site [chemical binding]; other site 536019009985 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019009986 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536019009987 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 536019009988 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536019009989 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536019009990 short chain dehydrogenase; Provisional; Region: PRK06198 536019009991 classical (c) SDRs; Region: SDR_c; cd05233 536019009992 NAD(P) binding site [chemical binding]; other site 536019009993 active site 536019009994 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019009995 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019009996 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019009997 putative active site [active] 536019009998 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019009999 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019010000 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019010001 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 536019010002 nudix motif; other site 536019010003 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 536019010004 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 536019010005 Excalibur calcium-binding domain; Region: Excalibur; cl05460 536019010006 DNA polymerase IV; Validated; Region: PRK03858 536019010007 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 536019010008 active site 536019010009 DNA binding site [nucleotide binding] 536019010010 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019010011 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019010012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019010013 NmrA-like family; Region: NmrA; pfam05368 536019010014 NAD(P) binding site [chemical binding]; other site 536019010015 active site 536019010016 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019010017 RibD C-terminal domain; Region: RibD_C; pfam01872 536019010018 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536019010019 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 536019010020 NADP binding site [chemical binding]; other site 536019010021 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019010022 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 536019010023 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019010024 RibD C-terminal domain; Region: RibD_C; cl17279 536019010025 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 536019010026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019010027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019010028 DNA binding residues [nucleotide binding] 536019010029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 536019010030 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 536019010031 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536019010032 DNA binding site [nucleotide binding] 536019010033 active site 536019010034 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 536019010035 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 536019010036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019010037 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536019010038 DNA binding site [nucleotide binding] 536019010039 active site 536019010040 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 536019010041 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019010042 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019010043 Uncharacterized conserved protein [Function unknown]; Region: COG5470 536019010044 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 536019010045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019010046 PAS fold; Region: PAS_3; pfam08447 536019010047 putative active site [active] 536019010048 heme pocket [chemical binding]; other site 536019010049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019010050 PAS fold; Region: PAS_3; pfam08447 536019010051 putative active site [active] 536019010052 heme pocket [chemical binding]; other site 536019010053 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019010054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019010055 metal binding site [ion binding]; metal-binding site 536019010056 active site 536019010057 I-site; other site 536019010058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019010059 Uncharacterized conserved protein [Function unknown]; Region: COG3246 536019010060 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019010061 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019010062 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019010063 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 536019010064 peptide binding site [polypeptide binding]; other site 536019010065 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019010066 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019010067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019010068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019010069 non-specific DNA binding site [nucleotide binding]; other site 536019010070 salt bridge; other site 536019010071 sequence-specific DNA binding site [nucleotide binding]; other site 536019010072 Cupin domain; Region: Cupin_2; pfam07883 536019010073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019010074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019010075 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019010076 adenosine deaminase; Provisional; Region: PRK09358 536019010077 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 536019010078 active site 536019010079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019010080 putative DNA binding site [nucleotide binding]; other site 536019010081 dimerization interface [polypeptide binding]; other site 536019010082 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 536019010083 putative Zn2+ binding site [ion binding]; other site 536019010084 AsnC family; Region: AsnC_trans_reg; pfam01037 536019010085 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 536019010086 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 536019010087 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 536019010088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019010089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019010090 homodimer interface [polypeptide binding]; other site 536019010091 catalytic residue [active] 536019010092 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 536019010093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019010094 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 536019010095 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 536019010096 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 536019010097 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 536019010098 potential frameshift: common BLAST hit: gi|319782651|ref|YP_004142127.1| GCN5-related N-acetyltransferase 536019010099 nickel responsive regulator; Provisional; Region: PRK02967 536019010100 PAS domain S-box; Region: sensory_box; TIGR00229 536019010101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019010102 putative active site [active] 536019010103 heme pocket [chemical binding]; other site 536019010104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019010105 HWE histidine kinase; Region: HWE_HK; pfam07536 536019010106 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019010107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019010108 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019010109 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019010110 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 536019010111 Predicted membrane protein [Function unknown]; Region: COG2259 536019010112 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536019010113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010114 S-adenosylmethionine binding site [chemical binding]; other site 536019010115 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 536019010116 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 536019010117 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 536019010118 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 536019010119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019010120 Coenzyme A binding pocket [chemical binding]; other site 536019010121 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 536019010122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 536019010123 methionine sulfoxide reductase A; Provisional; Region: PRK14054 536019010124 YKOF-related Family; Region: Ykof; pfam07615 536019010125 YKOF-related Family; Region: Ykof; pfam07615 536019010126 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019010127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010128 putative PBP binding loops; other site 536019010129 ABC-ATPase subunit interface; other site 536019010130 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019010131 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019010132 Walker A/P-loop; other site 536019010133 ATP binding site [chemical binding]; other site 536019010134 Q-loop/lid; other site 536019010135 ABC transporter signature motif; other site 536019010136 Walker B; other site 536019010137 D-loop; other site 536019010138 H-loop/switch region; other site 536019010139 NMT1/THI5 like; Region: NMT1; pfam09084 536019010140 TPR repeat; Region: TPR_11; pfam13414 536019010141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010142 binding surface 536019010143 TPR motif; other site 536019010144 TPR repeat; Region: TPR_11; pfam13414 536019010145 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 536019010146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010147 binding surface 536019010148 TPR motif; other site 536019010149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010150 binding surface 536019010151 TPR motif; other site 536019010152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010153 TPR motif; other site 536019010154 binding surface 536019010155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010156 binding surface 536019010157 TPR motif; other site 536019010158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010159 TPR motif; other site 536019010160 binding surface 536019010161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010162 binding surface 536019010163 TPR motif; other site 536019010164 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 536019010165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010166 binding surface 536019010167 TPR motif; other site 536019010168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010169 binding surface 536019010170 TPR motif; other site 536019010171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010172 binding surface 536019010173 TPR motif; other site 536019010174 TPR repeat; Region: TPR_11; pfam13414 536019010175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019010176 binding surface 536019010177 TPR motif; other site 536019010178 Phospholipid methyltransferase; Region: PEMT; cl17370 536019010179 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 536019010180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019010181 DNA-binding site [nucleotide binding]; DNA binding site 536019010182 UTRA domain; Region: UTRA; pfam07702 536019010183 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 536019010184 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019010185 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 536019010186 substrate binding site [chemical binding]; other site 536019010187 ATP binding site [chemical binding]; other site 536019010188 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019010189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019010190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010191 dimer interface [polypeptide binding]; other site 536019010192 conserved gate region; other site 536019010193 putative PBP binding loops; other site 536019010194 ABC-ATPase subunit interface; other site 536019010195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019010196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010197 dimer interface [polypeptide binding]; other site 536019010198 conserved gate region; other site 536019010199 putative PBP binding loops; other site 536019010200 ABC-ATPase subunit interface; other site 536019010201 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019010202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010203 Walker A/P-loop; other site 536019010204 ATP binding site [chemical binding]; other site 536019010205 Q-loop/lid; other site 536019010206 ABC transporter signature motif; other site 536019010207 Walker B; other site 536019010208 D-loop; other site 536019010209 H-loop/switch region; other site 536019010210 TOBE domain; Region: TOBE_2; pfam08402 536019010211 Protein of unknown function (DUF521); Region: DUF521; pfam04412 536019010212 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 536019010213 substrate binding site [chemical binding]; other site 536019010214 ligand binding site [chemical binding]; other site 536019010215 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 536019010216 substrate binding site [chemical binding]; other site 536019010217 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019010218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019010219 DNA binding site [nucleotide binding] 536019010220 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 536019010221 putative ligand binding site [chemical binding]; other site 536019010222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019010223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019010224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019010225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010226 putative PBP binding loops; other site 536019010227 dimer interface [polypeptide binding]; other site 536019010228 ABC-ATPase subunit interface; other site 536019010229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010230 dimer interface [polypeptide binding]; other site 536019010231 conserved gate region; other site 536019010232 putative PBP binding loops; other site 536019010233 ABC-ATPase subunit interface; other site 536019010234 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019010235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010236 Walker A/P-loop; other site 536019010237 ATP binding site [chemical binding]; other site 536019010238 Q-loop/lid; other site 536019010239 ABC transporter signature motif; other site 536019010240 Walker B; other site 536019010241 D-loop; other site 536019010242 H-loop/switch region; other site 536019010243 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019010244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010245 Walker A/P-loop; other site 536019010246 ATP binding site [chemical binding]; other site 536019010247 Q-loop/lid; other site 536019010248 ABC transporter signature motif; other site 536019010249 Walker B; other site 536019010250 D-loop; other site 536019010251 H-loop/switch region; other site 536019010252 TOBE domain; Region: TOBE_2; pfam08402 536019010253 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019010254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019010255 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019010256 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019010257 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536019010258 DNA interaction; other site 536019010259 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019010260 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019010261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010262 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010263 TM-ABC transporter signature motif; other site 536019010264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019010265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010266 Walker A/P-loop; other site 536019010267 ATP binding site [chemical binding]; other site 536019010268 Q-loop/lid; other site 536019010269 ABC transporter signature motif; other site 536019010270 Walker B; other site 536019010271 D-loop; other site 536019010272 H-loop/switch region; other site 536019010273 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 536019010274 active site 536019010275 catalytic residues [active] 536019010276 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 536019010277 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 536019010278 putative di-iron ligands [ion binding]; other site 536019010279 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 536019010280 [2Fe-2S] cluster binding site [ion binding]; other site 536019010281 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 536019010282 metal binding site [ion binding]; metal-binding site 536019010283 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 536019010284 active sites [active] 536019010285 tetramer interface [polypeptide binding]; other site 536019010286 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 536019010287 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 536019010288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019010289 putative substrate translocation pore; other site 536019010290 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010291 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010292 TM-ABC transporter signature motif; other site 536019010293 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019010294 ligand binding site [chemical binding]; other site 536019010295 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019010296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010298 TM-ABC transporter signature motif; other site 536019010299 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 536019010300 Strictosidine synthase; Region: Str_synth; pfam03088 536019010301 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 536019010302 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019010303 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019010304 Walker A/P-loop; other site 536019010305 ATP binding site [chemical binding]; other site 536019010306 Q-loop/lid; other site 536019010307 ABC transporter signature motif; other site 536019010308 Walker B; other site 536019010309 D-loop; other site 536019010310 H-loop/switch region; other site 536019010311 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019010312 Uncharacterized conserved protein [Function unknown]; Region: COG2128 536019010313 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 536019010314 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 536019010315 Amidohydrolase; Region: Amidohydro_2; pfam04909 536019010316 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 536019010317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 536019010318 metal ion-dependent adhesion site (MIDAS); other site 536019010319 MoxR-like ATPases [General function prediction only]; Region: COG0714 536019010320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019010321 Walker A motif; other site 536019010322 ATP binding site [chemical binding]; other site 536019010323 Walker B motif; other site 536019010324 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019010325 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019010326 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019010327 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019010328 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019010329 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019010330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019010331 catalytic loop [active] 536019010332 iron binding site [ion binding]; other site 536019010333 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019010334 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019010335 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536019010336 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 536019010337 putative hydrophobic ligand binding site [chemical binding]; other site 536019010338 protein interface [polypeptide binding]; other site 536019010339 gate; other site 536019010340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019010341 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010342 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010343 TM-ABC transporter signature motif; other site 536019010344 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019010345 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019010346 Walker A/P-loop; other site 536019010347 ATP binding site [chemical binding]; other site 536019010348 Q-loop/lid; other site 536019010349 ABC transporter signature motif; other site 536019010350 Walker B; other site 536019010351 D-loop; other site 536019010352 H-loop/switch region; other site 536019010353 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019010354 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019010355 ligand binding site [chemical binding]; other site 536019010356 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019010357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019010358 DNA-binding site [nucleotide binding]; DNA binding site 536019010359 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536019010360 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536019010361 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019010362 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019010363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019010364 NAD(P) binding site [chemical binding]; other site 536019010365 active site 536019010366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019010367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019010368 DNA-binding site [nucleotide binding]; DNA binding site 536019010369 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536019010370 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 536019010371 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 536019010372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019010373 putative substrate translocation pore; other site 536019010374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019010375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019010376 DNA binding site [nucleotide binding] 536019010377 domain linker motif; other site 536019010378 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 536019010379 putative ligand binding site [chemical binding]; other site 536019010380 putative dimerization interface [polypeptide binding]; other site 536019010381 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 536019010382 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019010383 putative ligand binding site [chemical binding]; other site 536019010384 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019010385 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019010386 Walker A/P-loop; other site 536019010387 ATP binding site [chemical binding]; other site 536019010388 Q-loop/lid; other site 536019010389 ABC transporter signature motif; other site 536019010390 Walker B; other site 536019010391 D-loop; other site 536019010392 H-loop/switch region; other site 536019010393 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019010394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010395 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010396 TM-ABC transporter signature motif; other site 536019010397 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010398 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010399 TM-ABC transporter signature motif; other site 536019010400 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 536019010401 AAA domain; Region: AAA_33; pfam13671 536019010402 ATP-binding site [chemical binding]; other site 536019010403 Gluconate-6-phosphate binding site [chemical binding]; other site 536019010404 Predicted transcriptional regulator [Transcription]; Region: COG1959 536019010405 Transcriptional regulator; Region: Rrf2; pfam02082 536019010406 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 536019010407 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536019010408 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 536019010409 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 536019010410 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 536019010411 Walker A/P-loop; other site 536019010412 ATP binding site [chemical binding]; other site 536019010413 Q-loop/lid; other site 536019010414 ABC transporter signature motif; other site 536019010415 Walker B; other site 536019010416 D-loop; other site 536019010417 H-loop/switch region; other site 536019010418 sulfate transport protein; Provisional; Region: cysT; CHL00187 536019010419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010420 dimer interface [polypeptide binding]; other site 536019010421 conserved gate region; other site 536019010422 putative PBP binding loops; other site 536019010423 ABC-ATPase subunit interface; other site 536019010424 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536019010425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010426 dimer interface [polypeptide binding]; other site 536019010427 conserved gate region; other site 536019010428 putative PBP binding loops; other site 536019010429 ABC-ATPase subunit interface; other site 536019010430 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 536019010431 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536019010432 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 536019010433 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 536019010434 Transglycosylase; Region: Transgly; pfam00912 536019010435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 536019010436 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 536019010437 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 536019010438 putative binding site; other site 536019010439 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 536019010440 MG2 domain; Region: A2M_N; pfam01835 536019010441 Alpha-2-macroglobulin family; Region: A2M; pfam00207 536019010442 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 536019010443 surface patch; other site 536019010444 thioester region; other site 536019010445 specificity defining residues; other site 536019010446 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 536019010447 Surface antigen; Region: Bac_surface_Ag; pfam01103 536019010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 536019010449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 536019010450 Family of unknown function (DUF490); Region: DUF490; pfam04357 536019010451 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019010452 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019010453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019010454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010455 dimer interface [polypeptide binding]; other site 536019010456 conserved gate region; other site 536019010457 putative PBP binding loops; other site 536019010458 ABC-ATPase subunit interface; other site 536019010459 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019010460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010461 dimer interface [polypeptide binding]; other site 536019010462 conserved gate region; other site 536019010463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019010464 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 536019010465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019010466 Walker A/P-loop; other site 536019010467 ATP binding site [chemical binding]; other site 536019010468 Q-loop/lid; other site 536019010469 ABC transporter signature motif; other site 536019010470 Walker B; other site 536019010471 D-loop; other site 536019010472 H-loop/switch region; other site 536019010473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019010474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019010475 Walker A/P-loop; other site 536019010476 ATP binding site [chemical binding]; other site 536019010477 Q-loop/lid; other site 536019010478 ABC transporter signature motif; other site 536019010479 Walker B; other site 536019010480 D-loop; other site 536019010481 H-loop/switch region; other site 536019010482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019010483 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019010484 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019010485 catalytic residue [active] 536019010486 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 536019010487 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019010488 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019010489 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019010490 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019010491 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019010492 Predicted membrane protein [Function unknown]; Region: COG2259 536019010493 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 536019010494 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019010495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019010496 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 536019010497 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 536019010498 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536019010499 putative active site pocket [active] 536019010500 dimerization interface [polypeptide binding]; other site 536019010501 putative catalytic residue [active] 536019010502 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 536019010503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010504 S-adenosylmethionine binding site [chemical binding]; other site 536019010505 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 536019010506 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 536019010507 homodimer interface [polypeptide binding]; other site 536019010508 active site 536019010509 FMN binding site [chemical binding]; other site 536019010510 substrate binding site [chemical binding]; other site 536019010511 4Fe-4S binding domain; Region: Fer4_6; pfam12837 536019010512 4Fe-4S binding domain; Region: Fer4; pfam00037 536019010513 Predicted transcriptional regulator [Transcription]; Region: COG1959 536019010514 Transcriptional regulator; Region: Rrf2; pfam02082 536019010515 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 536019010516 Uncharacterized conserved protein [Function unknown]; Region: COG2128 536019010517 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 536019010518 Predicted membrane protein [Function unknown]; Region: COG2259 536019010519 short chain dehydrogenase; Provisional; Region: PRK07041 536019010520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019010521 NAD(P) binding site [chemical binding]; other site 536019010522 active site 536019010523 short chain dehydrogenase; Provisional; Region: PRK12828 536019010524 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 536019010525 putative NAD(P) binding site [chemical binding]; other site 536019010526 active site 536019010527 Helix-turn-helix domain; Region: HTH_31; pfam13560 536019010528 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 536019010529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019010530 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 536019010531 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 536019010532 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019010533 inhibitor-cofactor binding pocket; inhibition site 536019010534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019010535 catalytic residue [active] 536019010536 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 536019010537 putative active site [active] 536019010538 allantoate amidohydrolase; Reviewed; Region: PRK12893 536019010539 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 536019010540 active site 536019010541 metal binding site [ion binding]; metal-binding site 536019010542 dimer interface [polypeptide binding]; other site 536019010543 phenylhydantoinase; Validated; Region: PRK08323 536019010544 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 536019010545 tetramer interface [polypeptide binding]; other site 536019010546 active site 536019010547 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 536019010548 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019010549 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019010550 Walker A/P-loop; other site 536019010551 ATP binding site [chemical binding]; other site 536019010552 Q-loop/lid; other site 536019010553 ABC transporter signature motif; other site 536019010554 Walker B; other site 536019010555 D-loop; other site 536019010556 H-loop/switch region; other site 536019010557 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019010558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010559 dimer interface [polypeptide binding]; other site 536019010560 conserved gate region; other site 536019010561 putative PBP binding loops; other site 536019010562 ABC-ATPase subunit interface; other site 536019010563 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019010564 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 536019010565 NMT1/THI5 like; Region: NMT1; pfam09084 536019010566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 536019010567 CHRD domain; Region: CHRD; pfam07452 536019010568 thiamine pyrophosphate protein; Validated; Region: PRK08199 536019010569 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019010570 PYR/PP interface [polypeptide binding]; other site 536019010571 dimer interface [polypeptide binding]; other site 536019010572 TPP binding site [chemical binding]; other site 536019010573 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019010574 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 536019010575 TPP-binding site [chemical binding]; other site 536019010576 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019010577 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019010578 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 536019010579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019010580 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 536019010581 B1 nucleotide binding pocket [chemical binding]; other site 536019010582 B2 nucleotide binding pocket [chemical binding]; other site 536019010583 CAS motifs; other site 536019010584 active site 536019010585 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 536019010586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010587 Walker A/P-loop; other site 536019010588 ATP binding site [chemical binding]; other site 536019010589 Q-loop/lid; other site 536019010590 ABC transporter signature motif; other site 536019010591 Walker B; other site 536019010592 D-loop; other site 536019010593 H-loop/switch region; other site 536019010594 ABC transporter; Region: ABC_tran_2; pfam12848 536019010595 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019010596 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 536019010597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010598 S-adenosylmethionine binding site [chemical binding]; other site 536019010599 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 536019010600 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 536019010601 dimer interface [polypeptide binding]; other site 536019010602 active site 536019010603 CoA binding pocket [chemical binding]; other site 536019010604 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019010605 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 536019010606 dimer interface [polypeptide binding]; other site 536019010607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019010608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019010609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019010610 short chain dehydrogenase; Provisional; Region: PRK08263 536019010611 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536019010612 NADP binding site [chemical binding]; other site 536019010613 active site 536019010614 steroid binding site; other site 536019010615 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536019010616 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 536019010617 homodimer interface [polypeptide binding]; other site 536019010618 substrate-cofactor binding pocket; other site 536019010619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019010620 catalytic residue [active] 536019010621 Uncharacterized conserved protein [Function unknown]; Region: COG5586 536019010622 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 536019010623 homodimer interaction site [polypeptide binding]; other site 536019010624 cofactor binding site; other site 536019010625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019010626 putative Zn2+ binding site [ion binding]; other site 536019010627 putative DNA binding site [nucleotide binding]; other site 536019010628 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536019010629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010630 S-adenosylmethionine binding site [chemical binding]; other site 536019010631 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 536019010632 FAD binding site [chemical binding]; other site 536019010633 EamA-like transporter family; Region: EamA; pfam00892 536019010634 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536019010635 EamA-like transporter family; Region: EamA; pfam00892 536019010636 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 536019010637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 536019010638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019010639 catalytic residue [active] 536019010640 Transglycosylase SLT domain; Region: SLT_2; pfam13406 536019010641 murein hydrolase B; Provisional; Region: PRK10760; cl17906 536019010642 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019010643 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 536019010644 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 536019010645 active site 536019010646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019010647 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019010648 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 536019010649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019010650 non-specific DNA binding site [nucleotide binding]; other site 536019010651 salt bridge; other site 536019010652 sequence-specific DNA binding site [nucleotide binding]; other site 536019010653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010654 S-adenosylmethionine binding site [chemical binding]; other site 536019010655 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 536019010656 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 536019010657 active site 536019010658 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 536019010659 5-oxoprolinase; Region: PLN02666 536019010660 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 536019010661 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 536019010662 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 536019010663 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 536019010664 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 536019010665 putative metal binding site [ion binding]; other site 536019010666 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019010667 HSP70 interaction site [polypeptide binding]; other site 536019010668 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 536019010669 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 536019010670 amidase catalytic site [active] 536019010671 Zn binding residues [ion binding]; other site 536019010672 substrate binding site [chemical binding]; other site 536019010673 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019010674 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019010675 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019010676 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019010677 catalytic residue [active] 536019010678 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 536019010679 cystathionine gamma-lyase; Validated; Region: PRK07582 536019010680 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 536019010681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019010682 catalytic residue [active] 536019010683 cell division protein MraZ; Reviewed; Region: PRK00326 536019010684 MraZ protein; Region: MraZ; pfam02381 536019010685 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 536019010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010687 S-adenosylmethionine binding site [chemical binding]; other site 536019010688 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 536019010689 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 536019010690 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 536019010691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 536019010692 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 536019010693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536019010694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536019010695 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 536019010696 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536019010697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536019010698 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 536019010699 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 536019010700 Mg++ binding site [ion binding]; other site 536019010701 putative catalytic motif [active] 536019010702 putative substrate binding site [chemical binding]; other site 536019010703 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 536019010704 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 536019010705 NAD(P) binding pocket [chemical binding]; other site 536019010706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536019010707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536019010708 cell division protein FtsW; Region: ftsW; TIGR02614 536019010709 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 536019010710 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 536019010711 active site 536019010712 homodimer interface [polypeptide binding]; other site 536019010713 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 536019010714 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536019010715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536019010716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536019010717 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 536019010718 FAD binding domain; Region: FAD_binding_4; pfam01565 536019010719 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 536019010720 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 536019010721 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 536019010722 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019010723 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 536019010724 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 536019010725 Cell division protein FtsQ; Region: FtsQ; pfam03799 536019010726 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 536019010727 Cell division protein FtsA; Region: FtsA; smart00842 536019010728 Cell division protein FtsA; Region: FtsA; pfam14450 536019010729 cell division protein FtsZ; Validated; Region: PRK09330 536019010730 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 536019010731 nucleotide binding site [chemical binding]; other site 536019010732 SulA interaction site; other site 536019010733 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 536019010734 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 536019010735 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 536019010736 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 536019010737 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 536019010738 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 536019010739 Walker A/P-loop; other site 536019010740 ATP binding site [chemical binding]; other site 536019010741 Q-loop/lid; other site 536019010742 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 536019010743 ABC transporter signature motif; other site 536019010744 Walker B; other site 536019010745 D-loop; other site 536019010746 H-loop/switch region; other site 536019010747 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 536019010748 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 536019010749 nucleotide binding pocket [chemical binding]; other site 536019010750 K-X-D-G motif; other site 536019010751 catalytic site [active] 536019010752 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 536019010753 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 536019010754 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 536019010755 Dimer interface [polypeptide binding]; other site 536019010756 BRCT sequence motif; other site 536019010757 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 536019010758 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 536019010759 Predicted membrane protein [Function unknown]; Region: COG4541 536019010760 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019010761 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019010762 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 536019010763 active site 536019010764 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 536019010765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019010766 S-adenosylmethionine binding site [chemical binding]; other site 536019010767 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 536019010768 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 536019010769 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 536019010770 Cu(I) binding site [ion binding]; other site 536019010771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 536019010772 CreA protein; Region: CreA; pfam05981 536019010773 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 536019010774 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 536019010775 trimer interface [polypeptide binding]; other site 536019010776 active site 536019010777 substrate binding site [chemical binding]; other site 536019010778 CoA binding site [chemical binding]; other site 536019010779 Low affinity iron permease; Region: Iron_permease; pfam04120 536019010780 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 536019010781 classical (c) SDRs; Region: SDR_c; cd05233 536019010782 NAD(P) binding site [chemical binding]; other site 536019010783 active site 536019010784 Predicted integral membrane protein [Function unknown]; Region: COG3548 536019010785 Bacterial SH3 domain; Region: SH3_3; pfam08239 536019010786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019010787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019010788 putative substrate translocation pore; other site 536019010789 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 536019010790 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 536019010791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019010792 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019010793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 536019010794 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019010795 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019010796 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019010797 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019010798 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019010799 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 536019010800 Uncharacterized conserved protein [Function unknown]; Region: COG3461 536019010801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019010802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019010803 DNA binding site [nucleotide binding] 536019010804 domain linker motif; other site 536019010805 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 536019010806 ligand binding site [chemical binding]; other site 536019010807 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019010808 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019010809 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019010810 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019010811 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 536019010812 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019010813 putative ligand binding site [chemical binding]; other site 536019010814 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019010815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010816 Walker A/P-loop; other site 536019010817 ATP binding site [chemical binding]; other site 536019010818 Q-loop/lid; other site 536019010819 ABC transporter signature motif; other site 536019010820 Walker B; other site 536019010821 D-loop; other site 536019010822 H-loop/switch region; other site 536019010823 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019010824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019010825 TM-ABC transporter signature motif; other site 536019010826 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 536019010827 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 536019010828 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 536019010829 Part of AAA domain; Region: AAA_19; pfam13245 536019010830 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 536019010831 Family description; Region: UvrD_C_2; pfam13538 536019010832 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 536019010833 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 536019010834 Trp docking motif [polypeptide binding]; other site 536019010835 putative active site [active] 536019010836 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536019010837 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 536019010838 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 536019010839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019010840 putative DNA binding site [nucleotide binding]; other site 536019010841 putative Zn2+ binding site [ion binding]; other site 536019010842 AsnC family; Region: AsnC_trans_reg; pfam01037 536019010843 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536019010844 active site 536019010845 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019010846 FAD binding domain; Region: FAD_binding_4; pfam01565 536019010847 Avidin family; Region: Avidin; pfam01382 536019010848 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 536019010849 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 536019010850 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 536019010851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019010852 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 536019010853 DNA binding residues [nucleotide binding] 536019010854 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019010855 MarR family; Region: MarR_2; pfam12802 536019010856 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 536019010857 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536019010858 Cl- selectivity filter; other site 536019010859 Cl- binding residues [ion binding]; other site 536019010860 pore gating glutamate residue; other site 536019010861 dimer interface [polypeptide binding]; other site 536019010862 FOG: CBS domain [General function prediction only]; Region: COG0517 536019010863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 536019010864 Ribbon-helix-helix domain; Region: RHH_4; cl01775 536019010865 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 536019010866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 536019010867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019010868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019010869 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 536019010870 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 536019010871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019010872 putative substrate translocation pore; other site 536019010873 Predicted ATPase [General function prediction only]; Region: COG3911 536019010874 AAA domain; Region: AAA_28; pfam13521 536019010875 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 536019010876 thymidylate synthase; Reviewed; Region: thyA; PRK01827 536019010877 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 536019010878 dimerization interface [polypeptide binding]; other site 536019010879 active site 536019010880 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 536019010881 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536019010882 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019010883 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536019010884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019010885 dimer interface [polypeptide binding]; other site 536019010886 conserved gate region; other site 536019010887 putative PBP binding loops; other site 536019010888 ABC-ATPase subunit interface; other site 536019010889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019010890 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 536019010891 Walker A/P-loop; other site 536019010892 ATP binding site [chemical binding]; other site 536019010893 Q-loop/lid; other site 536019010894 ABC transporter signature motif; other site 536019010895 Walker B; other site 536019010896 D-loop; other site 536019010897 H-loop/switch region; other site 536019010898 TOBE domain; Region: TOBE; pfam03459 536019010899 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 536019010900 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 536019010901 active site 536019010902 SAM binding site [chemical binding]; other site 536019010903 homodimer interface [polypeptide binding]; other site 536019010904 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 536019010905 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019010906 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 536019010907 folate binding site [chemical binding]; other site 536019010908 NADP+ binding site [chemical binding]; other site 536019010909 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 536019010910 HflK protein; Region: hflK; TIGR01933 536019010911 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 536019010912 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 536019010913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 536019010914 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 536019010915 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019010916 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019010917 protein binding site [polypeptide binding]; other site 536019010918 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019010919 protein binding site [polypeptide binding]; other site 536019010920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019010921 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 536019010922 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 536019010923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019010924 motif II; other site 536019010925 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 536019010926 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 536019010927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019010928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019010929 metal binding site [ion binding]; metal-binding site 536019010930 active site 536019010931 I-site; other site 536019010932 HerA helicase [Replication, recombination, and repair]; Region: COG0433 536019010933 Domain of unknown function DUF87; Region: DUF87; pfam01935 536019010934 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019010935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019010936 non-specific DNA binding site [nucleotide binding]; other site 536019010937 salt bridge; other site 536019010938 sequence-specific DNA binding site [nucleotide binding]; other site 536019010939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019010940 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019010941 Coenzyme A binding pocket [chemical binding]; other site 536019010942 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019010943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019010944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019010945 dimerization interface [polypeptide binding]; other site 536019010946 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 536019010947 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 536019010948 substrate binding pocket [chemical binding]; other site 536019010949 active site 536019010950 iron coordination sites [ion binding]; other site 536019010951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019010952 Zn2+ binding site [ion binding]; other site 536019010953 Mg2+ binding site [ion binding]; other site 536019010954 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019010955 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 536019010956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019010957 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 536019010958 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019010959 PYR/PP interface [polypeptide binding]; other site 536019010960 dimer interface [polypeptide binding]; other site 536019010961 TPP binding site [chemical binding]; other site 536019010962 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019010963 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 536019010964 TPP-binding site [chemical binding]; other site 536019010965 dimer interface [polypeptide binding]; other site 536019010966 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 536019010967 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 536019010968 putative valine binding site [chemical binding]; other site 536019010969 dimer interface [polypeptide binding]; other site 536019010970 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 536019010971 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019010972 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019010973 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019010974 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019010975 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019010976 Protein export membrane protein; Region: SecD_SecF; cl14618 536019010977 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 536019010978 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 536019010979 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 536019010980 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 536019010981 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 536019010982 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 536019010983 AAA domain; Region: AAA_30; pfam13604 536019010984 Family description; Region: UvrD_C_2; pfam13538 536019010985 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 536019010986 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 536019010987 active site 536019010988 hydrophilic channel; other site 536019010989 dimerization interface [polypeptide binding]; other site 536019010990 catalytic residues [active] 536019010991 active site lid [active] 536019010992 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 536019010993 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 536019010994 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 536019010995 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 536019010996 NADP binding site [chemical binding]; other site 536019010997 putative substrate binding site [chemical binding]; other site 536019010998 active site 536019010999 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 536019011000 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536019011001 NADP binding site [chemical binding]; other site 536019011002 Predicted transcriptional regulators [Transcription]; Region: COG1733 536019011003 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536019011004 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 536019011005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019011006 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019011007 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536019011008 C-terminal domain interface [polypeptide binding]; other site 536019011009 GSH binding site (G-site) [chemical binding]; other site 536019011010 dimer interface [polypeptide binding]; other site 536019011011 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 536019011012 N-terminal domain interface [polypeptide binding]; other site 536019011013 dimer interface [polypeptide binding]; other site 536019011014 substrate binding pocket (H-site) [chemical binding]; other site 536019011015 MarR family; Region: MarR_2; pfam12802 536019011016 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019011017 MarR family; Region: MarR_2; cl17246 536019011018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019011019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019011020 ketol-acid reductoisomerase; Provisional; Region: PRK05479 536019011021 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 536019011022 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 536019011023 BA14K-like protein; Region: BA14K; pfam07886 536019011024 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 536019011025 putative catalytic site [active] 536019011026 putative metal binding site [ion binding]; other site 536019011027 putative phosphate binding site [ion binding]; other site 536019011028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 536019011029 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 536019011030 FtsX-like permease family; Region: FtsX; pfam02687 536019011031 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 536019011032 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536019011033 Walker A/P-loop; other site 536019011034 ATP binding site [chemical binding]; other site 536019011035 Q-loop/lid; other site 536019011036 ABC transporter signature motif; other site 536019011037 Walker B; other site 536019011038 D-loop; other site 536019011039 H-loop/switch region; other site 536019011040 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019011041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019011042 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019011043 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 536019011044 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 536019011045 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 536019011046 putative dimer interface [polypeptide binding]; other site 536019011047 active site pocket [active] 536019011048 putative cataytic base [active] 536019011049 cobalamin synthase; Reviewed; Region: cobS; PRK00235 536019011050 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 536019011051 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019011052 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 536019011053 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 536019011054 active site 536019011055 SAM binding site [chemical binding]; other site 536019011056 homodimer interface [polypeptide binding]; other site 536019011057 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 536019011058 active site 536019011059 SAM binding site [chemical binding]; other site 536019011060 homodimer interface [polypeptide binding]; other site 536019011061 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 536019011062 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 536019011063 active site 536019011064 putative homodimer interface [polypeptide binding]; other site 536019011065 SAM binding site [chemical binding]; other site 536019011066 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 536019011067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019011068 S-adenosylmethionine binding site [chemical binding]; other site 536019011069 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 536019011070 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 536019011071 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 536019011072 active site 536019011073 SAM binding site [chemical binding]; other site 536019011074 homodimer interface [polypeptide binding]; other site 536019011075 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 536019011076 active site 536019011077 SAM binding site [chemical binding]; other site 536019011078 homodimer interface [polypeptide binding]; other site 536019011079 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 536019011080 Precorrin-8X methylmutase; Region: CbiC; pfam02570 536019011081 precorrin-3B synthase; Region: CobG; TIGR02435 536019011082 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536019011083 cobaltochelatase, CobN subunit; Region: cobalto_cobN; TIGR02257 536019011084 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 536019011085 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 536019011086 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 536019011087 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 536019011088 Predicted metal-binding protein [Function unknown]; Region: COG5469 536019011089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 536019011090 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 536019011091 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 536019011092 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 536019011093 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 536019011094 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 536019011095 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 536019011096 NADH dehydrogenase subunit D; Validated; Region: PRK06075 536019011097 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 536019011098 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 536019011099 putative dimer interface [polypeptide binding]; other site 536019011100 [2Fe-2S] cluster binding site [ion binding]; other site 536019011101 Uncharacterized conserved protein [Function unknown]; Region: COG3743 536019011102 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 536019011103 SLBB domain; Region: SLBB; pfam10531 536019011104 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 536019011105 Uncharacterized conserved protein [Function unknown]; Region: COG3743 536019011106 NADH dehydrogenase subunit G; Validated; Region: PRK09130 536019011107 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019011108 catalytic loop [active] 536019011109 iron binding site [ion binding]; other site 536019011110 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 536019011111 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 536019011112 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 536019011113 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 536019011114 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 536019011115 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 536019011116 4Fe-4S binding domain; Region: Fer4; pfam00037 536019011117 4Fe-4S binding domain; Region: Fer4; pfam00037 536019011118 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 536019011119 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 536019011120 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 536019011121 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 536019011122 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 536019011123 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536019011124 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 536019011125 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536019011126 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 536019011127 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536019011128 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 536019011129 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 536019011130 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 536019011131 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 536019011132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019011133 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 536019011134 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536019011135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019011136 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 536019011137 dimer interface [polypeptide binding]; other site 536019011138 substrate binding site [chemical binding]; other site 536019011139 metal binding site [ion binding]; metal-binding site 536019011140 Predicted secreted protein [Function unknown]; Region: COG5454 536019011141 prolyl-tRNA synthetase; Provisional; Region: PRK12325 536019011142 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 536019011143 dimer interface [polypeptide binding]; other site 536019011144 motif 1; other site 536019011145 active site 536019011146 motif 2; other site 536019011147 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019011148 active site 536019011149 motif 3; other site 536019011150 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 536019011151 anticodon binding site; other site 536019011152 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 536019011153 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 536019011154 FtsX-like permease family; Region: FtsX; pfam02687 536019011155 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 536019011156 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536019011157 Walker A/P-loop; other site 536019011158 ATP binding site [chemical binding]; other site 536019011159 Q-loop/lid; other site 536019011160 ABC transporter signature motif; other site 536019011161 Walker B; other site 536019011162 D-loop; other site 536019011163 H-loop/switch region; other site 536019011164 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 536019011165 hydrophobic ligand binding site; other site 536019011166 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 536019011167 active site 536019011168 putative substrate binding region [chemical binding]; other site 536019011169 lipoate-protein ligase B; Provisional; Region: PRK14341 536019011170 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536019011171 active site 536019011172 Int/Topo IB signature motif; other site 536019011173 DNA binding site [nucleotide binding] 536019011174 HNH endonuclease; Region: HNH_3; pfam13392 536019011175 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 536019011176 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 536019011177 dimer interface [polypeptide binding]; other site 536019011178 ssDNA binding site [nucleotide binding]; other site 536019011179 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019011180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 536019011181 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 536019011182 putative DNA binding surface [nucleotide binding]; other site 536019011183 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 536019011184 dimer interface [polypeptide binding]; other site 536019011185 beta-clamp/clamp loader binding surface; other site 536019011186 beta-clamp/translesion DNA polymerase binding surface; other site 536019011187 HD domain; Region: HD_3; cl17350 536019011188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 536019011189 non-specific DNA binding site [nucleotide binding]; other site 536019011190 salt bridge; other site 536019011191 sequence-specific DNA binding site [nucleotide binding]; other site 536019011192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019011193 sequence-specific DNA binding site [nucleotide binding]; other site 536019011194 salt bridge; other site 536019011195 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 536019011196 CHC2 zinc finger; Region: zf-CHC2; cl17510 536019011197 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 536019011198 GcrA cell cycle regulator; Region: GcrA; cl11564 536019011199 DEAD-like helicases superfamily; Region: DEXDc; smart00487 536019011200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019011201 ATP binding site [chemical binding]; other site 536019011202 putative Mg++ binding site [ion binding]; other site 536019011203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 536019011204 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 536019011205 DNA methylase; Region: N6_N4_Mtase; cl17433 536019011206 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 536019011207 D5 N terminal like; Region: D5_N; smart00885 536019011208 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 536019011209 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 536019011210 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 536019011211 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 536019011212 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 536019011213 tandem repeat interface [polypeptide binding]; other site 536019011214 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 536019011215 oligomer interface [polypeptide binding]; other site 536019011216 active site residues [active] 536019011217 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 536019011218 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 536019011219 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019011220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019011221 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019011222 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 536019011223 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 536019011224 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 536019011225 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 536019011226 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 536019011227 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 536019011228 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 536019011229 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 536019011230 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 536019011231 Zn binding site [ion binding]; other site 536019011232 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 536019011233 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 536019011234 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 536019011235 active site 536019011236 DNA binding site [nucleotide binding] 536019011237 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019011238 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011239 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019011240 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019011241 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019011243 HAMP domain; Region: HAMP; pfam00672 536019011244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019011245 ATP binding site [chemical binding]; other site 536019011246 Mg2+ binding site [ion binding]; other site 536019011247 G-X-G motif; other site 536019011248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019011249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019011250 active site 536019011251 phosphorylation site [posttranslational modification] 536019011252 intermolecular recognition site; other site 536019011253 dimerization interface [polypeptide binding]; other site 536019011254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019011255 DNA binding site [nucleotide binding] 536019011256 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 536019011257 Cupin; Region: Cupin_6; pfam12852 536019011258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019011259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019011260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019011261 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 536019011262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019011263 TAP-like protein; Region: Abhydrolase_4; pfam08386 536019011264 Domain of unknown function DUF302; Region: DUF302; pfam03625 536019011265 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 536019011266 CoA binding domain; Region: CoA_binding; smart00881 536019011267 CoA-ligase; Region: Ligase_CoA; pfam00549 536019011268 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 536019011269 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 536019011270 CoA-ligase; Region: Ligase_CoA; pfam00549 536019011271 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 536019011272 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 536019011273 homodimer interface [polypeptide binding]; other site 536019011274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011275 catalytic residue [active] 536019011276 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019011277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019011278 active site 536019011279 phosphorylation site [posttranslational modification] 536019011280 intermolecular recognition site; other site 536019011281 dimerization interface [polypeptide binding]; other site 536019011282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019011283 DNA binding residues [nucleotide binding] 536019011284 dimerization interface [polypeptide binding]; other site 536019011285 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 536019011286 MgtE intracellular N domain; Region: MgtE_N; smart00924 536019011287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 536019011288 Divalent cation transporter; Region: MgtE; cl00786 536019011289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019011290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019011291 metal binding site [ion binding]; metal-binding site 536019011292 active site 536019011293 I-site; other site 536019011294 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019011295 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 536019011296 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 536019011297 DNA binding residues [nucleotide binding] 536019011298 putative dimer interface [polypeptide binding]; other site 536019011299 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019011300 Predicted membrane protein [Function unknown]; Region: COG3503 536019011301 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536019011302 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019011303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019011305 putative substrate translocation pore; other site 536019011306 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 536019011307 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 536019011308 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 536019011309 homotrimer interface [polypeptide binding]; other site 536019011310 Walker A motif; other site 536019011311 GTP binding site [chemical binding]; other site 536019011312 Walker B motif; other site 536019011313 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 536019011314 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 536019011315 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 536019011316 homodimer interface [polypeptide binding]; other site 536019011317 Walker A motif; other site 536019011318 ATP binding site [chemical binding]; other site 536019011319 hydroxycobalamin binding site [chemical binding]; other site 536019011320 Walker B motif; other site 536019011321 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 536019011322 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 536019011323 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 536019011324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019011325 catalytic residue [active] 536019011326 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 536019011327 Creatinine amidohydrolase; Region: Creatininase; pfam02633 536019011328 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019011329 homotrimer interaction site [polypeptide binding]; other site 536019011330 putative active site [active] 536019011331 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019011332 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019011333 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019011334 Walker A/P-loop; other site 536019011335 ATP binding site [chemical binding]; other site 536019011336 Q-loop/lid; other site 536019011337 ABC transporter signature motif; other site 536019011338 Walker B; other site 536019011339 D-loop; other site 536019011340 H-loop/switch region; other site 536019011341 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019011342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019011343 dimer interface [polypeptide binding]; other site 536019011344 conserved gate region; other site 536019011345 putative PBP binding loops; other site 536019011346 ABC-ATPase subunit interface; other site 536019011347 cytosine deaminase-like protein; Validated; Region: PRK07583 536019011348 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 536019011349 active site 536019011350 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019011351 FAD binding domain; Region: FAD_binding_4; pfam01565 536019011352 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 536019011353 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019011354 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 536019011355 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019011356 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019011357 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011358 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019011359 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019011360 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011361 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 536019011362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019011363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011364 homodimer interface [polypeptide binding]; other site 536019011365 catalytic residue [active] 536019011366 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 536019011367 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 536019011368 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019011369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011370 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019011371 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019011372 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011373 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 536019011374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019011375 non-specific DNA binding site [nucleotide binding]; other site 536019011376 salt bridge; other site 536019011377 sequence-specific DNA binding site [nucleotide binding]; other site 536019011378 Cupin domain; Region: Cupin_2; pfam07883 536019011379 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 536019011380 putative FMN binding site [chemical binding]; other site 536019011381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019011383 putative substrate translocation pore; other site 536019011384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011385 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 536019011386 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 536019011387 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019011388 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011389 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 536019011390 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 536019011391 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011392 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 536019011393 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536019011394 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 536019011395 hypothetical protein; Validated; Region: PRK08238 536019011396 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 536019011397 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 536019011398 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019011399 FAD binding domain; Region: FAD_binding_4; pfam01565 536019011400 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 536019011401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019011402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019011403 NAD(P) binding site [chemical binding]; other site 536019011404 active site 536019011405 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 536019011406 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019011407 inhibitor-cofactor binding pocket; inhibition site 536019011408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011409 catalytic residue [active] 536019011410 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 536019011411 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019011412 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011413 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019011414 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011415 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 536019011416 metal ion-dependent adhesion site (MIDAS); other site 536019011417 Beta/Gamma crystallin; Region: Crystall; cl02528 536019011418 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019011419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019011420 substrate binding pocket [chemical binding]; other site 536019011421 membrane-bound complex binding site; other site 536019011422 hinge residues; other site 536019011423 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019011424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019011425 dimer interface [polypeptide binding]; other site 536019011426 conserved gate region; other site 536019011427 putative PBP binding loops; other site 536019011428 ABC-ATPase subunit interface; other site 536019011429 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019011430 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019011431 Walker A/P-loop; other site 536019011432 ATP binding site [chemical binding]; other site 536019011433 Q-loop/lid; other site 536019011434 ABC transporter signature motif; other site 536019011435 Walker B; other site 536019011436 D-loop; other site 536019011437 H-loop/switch region; other site 536019011438 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019011439 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 536019011440 conserved cys residue [active] 536019011441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019011442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019011443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019011444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019011445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019011446 dimerization interface [polypeptide binding]; other site 536019011447 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 536019011448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019011449 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 536019011450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019011451 catalytic loop [active] 536019011452 iron binding site [ion binding]; other site 536019011453 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 536019011454 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 536019011455 substrate binding pocket [chemical binding]; other site 536019011456 dimer interface [polypeptide binding]; other site 536019011457 inhibitor binding site; inhibition site 536019011458 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 536019011459 FAD binding site [chemical binding]; other site 536019011460 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 536019011461 Virulence factor; Region: Virulence_fact; pfam13769 536019011462 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 536019011463 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 536019011464 putative active site [active] 536019011465 putative cosubstrate binding site; other site 536019011466 putative substrate binding site [chemical binding]; other site 536019011467 catalytic site [active] 536019011468 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019011469 extended (e) SDRs; Region: SDR_e; cd08946 536019011470 NAD(P) binding site [chemical binding]; other site 536019011471 active site 536019011472 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 536019011473 Entericidin EcnA/B family; Region: Entericidin; cl02322 536019011474 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 536019011475 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 536019011476 B12 binding site [chemical binding]; other site 536019011477 cobalt ligand [ion binding]; other site 536019011478 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 536019011479 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 536019011480 cobalamin binding site [chemical binding]; other site 536019011481 dimer interface [polypeptide binding]; other site 536019011482 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 536019011483 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536019011484 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 536019011485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019011486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019011487 DNA binding residues [nucleotide binding] 536019011488 von Willebrand factor; Region: vWF_A; pfam12450 536019011489 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 536019011490 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 536019011491 metal ion-dependent adhesion site (MIDAS); other site 536019011492 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 536019011493 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 536019011494 catalytic triad [active] 536019011495 methionine synthase I; Validated; Region: PRK07534 536019011496 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 536019011497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019011498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019011499 non-specific DNA binding site [nucleotide binding]; other site 536019011500 salt bridge; other site 536019011501 sequence-specific DNA binding site [nucleotide binding]; other site 536019011502 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 536019011503 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 536019011504 putative di-iron ligands [ion binding]; other site 536019011505 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 536019011506 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019011507 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019011508 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019011509 active site 536019011510 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019011511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019011512 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019011513 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019011514 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 536019011515 putative active site [active] 536019011516 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 536019011517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019011519 putative substrate translocation pore; other site 536019011520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019011521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011522 putative substrate translocation pore; other site 536019011523 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 536019011524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019011525 putative aminotransferase; Validated; Region: PRK07480 536019011526 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019011527 inhibitor-cofactor binding pocket; inhibition site 536019011528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011529 catalytic residue [active] 536019011530 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 536019011531 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019011532 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 536019011533 hypothetical protein; Reviewed; Region: PRK12275 536019011534 four helix bundle protein; Region: TIGR02436 536019011535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019011536 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 536019011537 substrate binding pocket [chemical binding]; other site 536019011538 FAD binding site [chemical binding]; other site 536019011539 catalytic base [active] 536019011540 cobyric acid synthase; Provisional; Region: PRK00784 536019011541 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019011542 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019011543 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 536019011544 catalytic triad [active] 536019011545 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 536019011546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019011547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019011548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019011549 hypothetical protein; Provisional; Region: PRK10621 536019011550 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 536019011551 tellurium resistance terB-like protein; Region: terB_like; cd07177 536019011552 metal binding site [ion binding]; metal-binding site 536019011553 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 536019011554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019011555 Walker A/P-loop; other site 536019011556 ATP binding site [chemical binding]; other site 536019011557 Q-loop/lid; other site 536019011558 ABC transporter signature motif; other site 536019011559 Walker B; other site 536019011560 D-loop; other site 536019011561 H-loop/switch region; other site 536019011562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019011563 Walker A/P-loop; other site 536019011564 ATP binding site [chemical binding]; other site 536019011565 Q-loop/lid; other site 536019011566 ABC transporter signature motif; other site 536019011567 Walker B; other site 536019011568 D-loop; other site 536019011569 H-loop/switch region; other site 536019011570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019011571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019011572 dimer interface [polypeptide binding]; other site 536019011573 conserved gate region; other site 536019011574 putative PBP binding loops; other site 536019011575 ABC-ATPase subunit interface; other site 536019011576 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019011577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019011578 dimer interface [polypeptide binding]; other site 536019011579 conserved gate region; other site 536019011580 putative PBP binding loops; other site 536019011581 ABC-ATPase subunit interface; other site 536019011582 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019011583 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 536019011584 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 536019011585 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like6; cd08011 536019011586 metal binding site [ion binding]; metal-binding site 536019011587 putative dimer interface [polypeptide binding]; other site 536019011588 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019011589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019011590 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 536019011591 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 536019011592 putative acyl-acceptor binding pocket; other site 536019011593 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019011594 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 536019011595 putative NAD(P) binding site [chemical binding]; other site 536019011596 structural Zn binding site [ion binding]; other site 536019011597 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 536019011598 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019011599 dimer interface [polypeptide binding]; other site 536019011600 active site 536019011601 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 536019011602 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 536019011603 active site 536019011604 acyl carrier protein; Provisional; Region: PRK06508 536019011605 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 536019011606 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 536019011607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019011608 catalytic core [active] 536019011609 Caspase domain; Region: Peptidase_C14; pfam00656 536019011610 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019011611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 536019011612 Predicted permeases [General function prediction only]; Region: COG0679 536019011613 succinic semialdehyde dehydrogenase; Region: PLN02278 536019011614 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536019011615 tetramerization interface [polypeptide binding]; other site 536019011616 NAD(P) binding site [chemical binding]; other site 536019011617 catalytic residues [active] 536019011618 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 536019011619 active site 536019011620 catalytic residues [active] 536019011621 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 536019011622 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019011623 substrate binding site [chemical binding]; other site 536019011624 ATP binding site [chemical binding]; other site 536019011625 YtkA-like; Region: YtkA; pfam13115 536019011626 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 536019011627 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019011628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019011629 putative DNA binding site [nucleotide binding]; other site 536019011630 putative Zn2+ binding site [ion binding]; other site 536019011631 AsnC family; Region: AsnC_trans_reg; pfam01037 536019011632 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 536019011633 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 536019011634 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 536019011635 Glutamate binding site [chemical binding]; other site 536019011636 NAD binding site [chemical binding]; other site 536019011637 catalytic residues [active] 536019011638 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019011639 NAD(P) binding site [chemical binding]; other site 536019011640 catalytic residues [active] 536019011641 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019011642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019011643 active site 536019011644 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 536019011645 Gram-negative bacterial tonB protein; Region: TonB; cl10048 536019011646 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 536019011647 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536019011648 N-terminal plug; other site 536019011649 ligand-binding site [chemical binding]; other site 536019011650 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 536019011651 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 536019011652 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 536019011653 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 536019011654 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 536019011655 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 536019011656 putative hemin binding site; other site 536019011657 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 536019011658 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 536019011659 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536019011660 ABC-ATPase subunit interface; other site 536019011661 dimer interface [polypeptide binding]; other site 536019011662 putative PBP binding regions; other site 536019011663 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 536019011664 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536019011665 Walker A/P-loop; other site 536019011666 ATP binding site [chemical binding]; other site 536019011667 Q-loop/lid; other site 536019011668 ABC transporter signature motif; other site 536019011669 Walker B; other site 536019011670 D-loop; other site 536019011671 H-loop/switch region; other site 536019011672 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 536019011673 Rrf2 family protein; Region: rrf2_super; TIGR00738 536019011674 Predicted membrane protein [Function unknown]; Region: COG2733 536019011675 Uncharacterized conserved protein [Function unknown]; Region: COG5490 536019011676 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 536019011677 putative active site [active] 536019011678 putative catalytic site [active] 536019011679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019011680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019011681 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 536019011682 putative substrate binding pocket [chemical binding]; other site 536019011683 putative dimerization interface [polypeptide binding]; other site 536019011684 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536019011685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019011686 DNA-binding site [nucleotide binding]; DNA binding site 536019011687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019011688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011689 homodimer interface [polypeptide binding]; other site 536019011690 catalytic residue [active] 536019011691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019011692 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 536019011693 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 536019011694 putative NAD(P) binding site [chemical binding]; other site 536019011695 catalytic Zn binding site [ion binding]; other site 536019011696 structural Zn binding site [ion binding]; other site 536019011697 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 536019011698 maleylacetoacetate isomerase; Region: maiA; TIGR01262 536019011699 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 536019011700 C-terminal domain interface [polypeptide binding]; other site 536019011701 GSH binding site (G-site) [chemical binding]; other site 536019011702 putative dimer interface [polypeptide binding]; other site 536019011703 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 536019011704 dimer interface [polypeptide binding]; other site 536019011705 N-terminal domain interface [polypeptide binding]; other site 536019011706 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 536019011707 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536019011708 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019011709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019011710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019011711 active site 536019011712 phosphorylation site [posttranslational modification] 536019011713 intermolecular recognition site; other site 536019011714 dimerization interface [polypeptide binding]; other site 536019011715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019011716 DNA binding residues [nucleotide binding] 536019011717 dimerization interface [polypeptide binding]; other site 536019011718 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 536019011719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019011720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019011721 dimer interface [polypeptide binding]; other site 536019011722 phosphorylation site [posttranslational modification] 536019011723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019011724 ATP binding site [chemical binding]; other site 536019011725 Mg2+ binding site [ion binding]; other site 536019011726 G-X-G motif; other site 536019011727 Response regulator receiver domain; Region: Response_reg; pfam00072 536019011728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019011729 active site 536019011730 phosphorylation site [posttranslational modification] 536019011731 intermolecular recognition site; other site 536019011732 dimerization interface [polypeptide binding]; other site 536019011733 Uncharacterized conserved protein [Function unknown]; Region: COG3287 536019011734 FIST N domain; Region: FIST; pfam08495 536019011735 FIST C domain; Region: FIST_C; pfam10442 536019011736 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 536019011737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 536019011738 catalytic loop [active] 536019011739 iron binding site [ion binding]; other site 536019011740 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536019011741 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019011742 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019011743 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019011744 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536019011745 FAD binding domain; Region: FAD_binding_4; pfam01565 536019011746 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019011747 Caspase domain; Region: Peptidase_C14; pfam00656 536019011748 active site 536019011749 substrate pocket [chemical binding]; other site 536019011750 proteolytic cleavage site; other site 536019011751 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 536019011752 putative binding site; other site 536019011753 PAN domain; Region: PAN_4; pfam14295 536019011754 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 536019011755 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 536019011756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019011757 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 536019011758 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 536019011759 putative hydrophobic ligand binding site [chemical binding]; other site 536019011760 Uncharacterized conserved protein [Function unknown]; Region: COG2128 536019011761 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 536019011762 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019011763 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019011764 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536019011765 putative dimer interface [polypeptide binding]; other site 536019011766 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019011767 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 536019011768 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 536019011769 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 536019011770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 536019011771 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 536019011772 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 536019011773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019011774 S-adenosylmethionine binding site [chemical binding]; other site 536019011775 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 536019011776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 536019011777 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 536019011778 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 536019011779 HIGH motif; other site 536019011780 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 536019011781 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 536019011782 active site 536019011783 KMSKS motif; other site 536019011784 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 536019011785 tRNA binding surface [nucleotide binding]; other site 536019011786 anticodon binding site; other site 536019011787 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 536019011788 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 536019011789 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 536019011790 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 536019011791 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536019011792 Sel1-like repeats; Region: SEL1; smart00671 536019011793 Sel1-like repeats; Region: SEL1; smart00671 536019011794 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 536019011795 putative catalytic site [active] 536019011796 putative phosphate binding site [ion binding]; other site 536019011797 active site 536019011798 metal binding site A [ion binding]; metal-binding site 536019011799 DNA binding site [nucleotide binding] 536019011800 putative AP binding site [nucleotide binding]; other site 536019011801 putative metal binding site B [ion binding]; other site 536019011802 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 536019011803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019011804 active site 536019011805 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 536019011806 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 536019011807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019011808 Zn2+ binding site [ion binding]; other site 536019011809 Mg2+ binding site [ion binding]; other site 536019011810 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 536019011811 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 536019011812 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 536019011813 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 536019011814 active site 536019011815 HIGH motif; other site 536019011816 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536019011817 KMSK motif region; other site 536019011818 tRNA binding surface [nucleotide binding]; other site 536019011819 DALR anticodon binding domain; Region: DALR_1; smart00836 536019011820 anticodon binding site; other site 536019011821 Sporulation related domain; Region: SPOR; pfam05036 536019011822 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 536019011823 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 536019011824 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 536019011825 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 536019011826 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 536019011827 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 536019011828 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 536019011829 seryl-tRNA synthetase; Provisional; Region: PRK05431 536019011830 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 536019011831 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 536019011832 dimer interface [polypeptide binding]; other site 536019011833 active site 536019011834 motif 1; other site 536019011835 motif 2; other site 536019011836 motif 3; other site 536019011837 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 536019011838 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 536019011839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019011840 S-adenosylmethionine binding site [chemical binding]; other site 536019011841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536019011842 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 536019011843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536019011844 Peptidase family M23; Region: Peptidase_M23; pfam01551 536019011845 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019011846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019011847 NAD(P) binding site [chemical binding]; other site 536019011848 active site 536019011849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536019011850 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019011851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019011852 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 536019011853 Protein of unknown function (DUF815); Region: DUF815; pfam05673 536019011854 Walker A motif; other site 536019011855 ATP binding site [chemical binding]; other site 536019011856 Walker B motif; other site 536019011857 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 536019011858 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 536019011859 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 536019011860 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 536019011861 Protein export membrane protein; Region: SecD_SecF; pfam02355 536019011862 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 536019011863 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 536019011864 substrate binding pocket [chemical binding]; other site 536019011865 substrate-Mg2+ binding site; other site 536019011866 aspartate-rich region 1; other site 536019011867 aspartate-rich region 2; other site 536019011868 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 536019011869 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 536019011870 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 536019011871 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 536019011872 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 536019011873 Glucose inhibited division protein A; Region: GIDA; pfam01134 536019011874 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019011875 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019011876 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 536019011877 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 536019011878 trigger factor; Provisional; Region: tig; PRK01490 536019011879 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536019011880 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 536019011881 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019011882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019011883 DNA-binding site [nucleotide binding]; DNA binding site 536019011884 FCD domain; Region: FCD; pfam07729 536019011885 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019011886 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019011887 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019011888 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019011889 Walker A/P-loop; other site 536019011890 ATP binding site [chemical binding]; other site 536019011891 Q-loop/lid; other site 536019011892 ABC transporter signature motif; other site 536019011893 Walker B; other site 536019011894 D-loop; other site 536019011895 H-loop/switch region; other site 536019011896 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019011897 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019011898 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019011899 TM-ABC transporter signature motif; other site 536019011900 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019011901 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019011902 TM-ABC transporter signature motif; other site 536019011903 short chain dehydrogenase; Provisional; Region: PRK12829 536019011904 classical (c) SDRs; Region: SDR_c; cd05233 536019011905 NAD(P) binding site [chemical binding]; other site 536019011906 active site 536019011907 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 536019011908 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019011909 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019011910 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 536019011911 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 536019011912 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 536019011913 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 536019011914 metal binding site [ion binding]; metal-binding site 536019011915 dimer interface [polypeptide binding]; other site 536019011916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019011917 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019011918 TM-ABC transporter signature motif; other site 536019011919 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019011920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019011921 TM-ABC transporter signature motif; other site 536019011922 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019011923 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019011924 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019011925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019011926 Walker A/P-loop; other site 536019011927 ATP binding site [chemical binding]; other site 536019011928 Q-loop/lid; other site 536019011929 ABC transporter signature motif; other site 536019011930 Walker B; other site 536019011931 D-loop; other site 536019011932 H-loop/switch region; other site 536019011933 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 536019011934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019011935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019011936 DNA binding site [nucleotide binding] 536019011937 domain linker motif; other site 536019011938 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019011939 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 536019011940 substrate binding site [chemical binding]; other site 536019011941 ATP binding site [chemical binding]; other site 536019011942 hypothetical protein; Reviewed; Region: PRK00024 536019011943 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 536019011944 MPN+ (JAMM) motif; other site 536019011945 Zinc-binding site [ion binding]; other site 536019011946 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 536019011947 active site 536019011948 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019011949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 536019011950 Peptidase M15; Region: Peptidase_M15_3; cl01194 536019011951 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 536019011952 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 536019011953 aminotransferase; Validated; Region: PRK09148 536019011954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019011955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019011956 homodimer interface [polypeptide binding]; other site 536019011957 catalytic residue [active] 536019011958 homoserine dehydrogenase; Provisional; Region: PRK06349 536019011959 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 536019011960 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 536019011961 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 536019011962 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 536019011963 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 536019011964 putative active site [active] 536019011965 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 536019011966 DHH family; Region: DHH; pfam01368 536019011967 DHHA1 domain; Region: DHHA1; pfam02272 536019011968 RibD C-terminal domain; Region: RibD_C; pfam01872 536019011969 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019011970 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 536019011971 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 536019011972 active site 536019011973 nucleophile elbow; other site 536019011974 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 536019011975 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 536019011976 GTP cyclohydrolase I; Provisional; Region: PLN03044 536019011977 active site 536019011978 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 536019011979 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 536019011980 trimerization site [polypeptide binding]; other site 536019011981 active site 536019011982 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019011983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019011984 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019011985 dimerization interface [polypeptide binding]; other site 536019011986 substrate binding pocket [chemical binding]; other site 536019011987 hypothetical protein; Validated; Region: PRK00041 536019011988 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 536019011989 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 536019011990 Leucine carboxyl methyltransferase; Region: LCM; cl01306 536019011991 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 536019011992 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 536019011993 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 536019011994 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 536019011995 active site 536019011996 dimer interface [polypeptide binding]; other site 536019011997 motif 1; other site 536019011998 motif 2; other site 536019011999 motif 3; other site 536019012000 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 536019012001 anticodon binding site; other site 536019012002 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 536019012003 putative acyl-acceptor binding pocket; other site 536019012004 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 536019012005 putative FMN binding site [chemical binding]; other site 536019012006 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 536019012007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019012008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019012009 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019012010 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 536019012011 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 536019012012 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 536019012013 putative active site [active] 536019012014 putative catalytic site [active] 536019012015 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 536019012016 Fusaric acid resistance protein family; Region: FUSC; pfam04632 536019012017 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536019012018 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 536019012019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019012020 Mg2+ binding site [ion binding]; other site 536019012021 G-X-G motif; other site 536019012022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 536019012023 anchoring element; other site 536019012024 dimer interface [polypeptide binding]; other site 536019012025 ATP binding site [chemical binding]; other site 536019012026 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 536019012027 active site 536019012028 metal binding site [ion binding]; metal-binding site 536019012029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 536019012030 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 536019012031 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 536019012032 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 536019012033 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 536019012034 BON domain; Region: BON; pfam04972 536019012035 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 536019012036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019012037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019012038 active site 536019012039 phosphorylation site [posttranslational modification] 536019012040 intermolecular recognition site; other site 536019012041 dimerization interface [polypeptide binding]; other site 536019012042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 536019012043 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 536019012044 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 536019012045 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019012046 ATP binding site [chemical binding]; other site 536019012047 Walker A motif; other site 536019012048 hexamer interface [polypeptide binding]; other site 536019012049 Walker B motif; other site 536019012050 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 536019012051 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019012052 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 536019012053 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019012054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019012055 binding surface 536019012056 TPR motif; other site 536019012057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019012058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019012059 metal binding site [ion binding]; metal-binding site 536019012060 active site 536019012061 I-site; other site 536019012062 glycine dehydrogenase; Provisional; Region: PRK05367 536019012063 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 536019012064 tetramer interface [polypeptide binding]; other site 536019012065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019012066 catalytic residue [active] 536019012067 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 536019012068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019012069 catalytic residue [active] 536019012070 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 536019012071 lipoyl attachment site [posttranslational modification]; other site 536019012072 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 536019012073 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019012074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019012075 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019012076 Coenzyme A binding pocket [chemical binding]; other site 536019012077 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 536019012078 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 536019012079 Moco binding site; other site 536019012080 metal coordination site [ion binding]; other site 536019012081 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 536019012082 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 536019012083 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 536019012084 Predicted membrane protein [Function unknown]; Region: COG4291 536019012085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 536019012086 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 536019012087 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 536019012088 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 536019012089 substrate binding site [chemical binding]; other site 536019012090 catalytic Zn binding site [ion binding]; other site 536019012091 NAD binding site [chemical binding]; other site 536019012092 structural Zn binding site [ion binding]; other site 536019012093 dimer interface [polypeptide binding]; other site 536019012094 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 536019012095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019012096 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 536019012097 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536019012098 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536019012099 carboxyltransferase (CT) interaction site; other site 536019012100 biotinylation site [posttranslational modification]; other site 536019012101 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 536019012102 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 536019012103 putative active site [active] 536019012104 putative PHP Thumb interface [polypeptide binding]; other site 536019012105 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 536019012106 generic binding surface II; other site 536019012107 generic binding surface I; other site 536019012108 Ion channel; Region: Ion_trans_2; pfam07885 536019012109 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019012110 EamA-like transporter family; Region: EamA; pfam00892 536019012111 EamA-like transporter family; Region: EamA; pfam00892 536019012112 DNA polymerase IV; Provisional; Region: PRK02794 536019012113 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 536019012114 active site 536019012115 DNA binding site [nucleotide binding] 536019012116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019012117 Coenzyme A binding pocket [chemical binding]; other site 536019012118 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 536019012119 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019012120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019012121 active site 536019012122 phosphorylation site [posttranslational modification] 536019012123 intermolecular recognition site; other site 536019012124 dimerization interface [polypeptide binding]; other site 536019012125 response regulator PleD; Reviewed; Region: pleD; PRK09581 536019012126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019012127 active site 536019012128 phosphorylation site [posttranslational modification] 536019012129 intermolecular recognition site; other site 536019012130 dimerization interface [polypeptide binding]; other site 536019012131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 536019012132 active site 536019012133 phosphorylation site [posttranslational modification] 536019012134 intermolecular recognition site; other site 536019012135 dimerization interface [polypeptide binding]; other site 536019012136 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019012137 metal binding site [ion binding]; metal-binding site 536019012138 active site 536019012139 I-site; other site 536019012140 hypothetical protein; Provisional; Region: PRK06834 536019012141 hypothetical protein; Provisional; Region: PRK07236 536019012142 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019012143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019012144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019012145 DNA-binding site [nucleotide binding]; DNA binding site 536019012146 FCD domain; Region: FCD; pfam07729 536019012147 hypothetical protein; Provisional; Region: PRK05968 536019012148 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536019012149 homodimer interface [polypeptide binding]; other site 536019012150 substrate-cofactor binding pocket; other site 536019012151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019012152 catalytic residue [active] 536019012153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019012154 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019012155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012156 dimer interface [polypeptide binding]; other site 536019012157 conserved gate region; other site 536019012158 putative PBP binding loops; other site 536019012159 ABC-ATPase subunit interface; other site 536019012160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019012161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012162 dimer interface [polypeptide binding]; other site 536019012163 conserved gate region; other site 536019012164 putative PBP binding loops; other site 536019012165 ABC-ATPase subunit interface; other site 536019012166 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019012167 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019012168 Walker A/P-loop; other site 536019012169 ATP binding site [chemical binding]; other site 536019012170 Q-loop/lid; other site 536019012171 ABC transporter signature motif; other site 536019012172 Walker B; other site 536019012173 D-loop; other site 536019012174 H-loop/switch region; other site 536019012175 TOBE domain; Region: TOBE_2; pfam08402 536019012176 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 536019012177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 536019012178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019012179 putative substrate translocation pore; other site 536019012180 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019012181 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 536019012182 hypothetical protein; Provisional; Region: PRK05978 536019012183 ribonuclease R; Region: RNase_R; TIGR02063 536019012184 RNB domain; Region: RNB; pfam00773 536019012185 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 536019012186 RNA binding site [nucleotide binding]; other site 536019012187 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 536019012188 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 536019012189 active site 536019012190 interdomain interaction site; other site 536019012191 putative metal-binding site [ion binding]; other site 536019012192 nucleotide binding site [chemical binding]; other site 536019012193 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 536019012194 domain I; other site 536019012195 DNA binding groove [nucleotide binding] 536019012196 phosphate binding site [ion binding]; other site 536019012197 domain II; other site 536019012198 domain III; other site 536019012199 nucleotide binding site [chemical binding]; other site 536019012200 catalytic site [active] 536019012201 domain IV; other site 536019012202 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536019012203 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 536019012204 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 536019012205 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 536019012206 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 536019012207 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 536019012208 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 536019012209 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 536019012210 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 536019012211 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 536019012212 Substrate binding site; other site 536019012213 Mg++ binding site; other site 536019012214 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 536019012215 active site 536019012216 substrate binding site [chemical binding]; other site 536019012217 CoA binding site [chemical binding]; other site 536019012218 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 536019012219 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 536019012220 glutaminase active site [active] 536019012221 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 536019012222 dimer interface [polypeptide binding]; other site 536019012223 active site 536019012224 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536019012225 dimer interface [polypeptide binding]; other site 536019012226 active site 536019012227 Uncharacterized conserved protein [Function unknown]; Region: COG2928 536019012228 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 536019012229 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 536019012230 generic binding surface II; other site 536019012231 ssDNA binding site; other site 536019012232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019012233 ATP binding site [chemical binding]; other site 536019012234 putative Mg++ binding site [ion binding]; other site 536019012235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019012236 nucleotide binding region [chemical binding]; other site 536019012237 ATP-binding site [chemical binding]; other site 536019012238 Uncharacterized conserved protein [Function unknown]; Region: COG2938 536019012239 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 536019012240 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 536019012241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019012242 ATP binding site [chemical binding]; other site 536019012243 putative Mg++ binding site [ion binding]; other site 536019012244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019012245 nucleotide binding region [chemical binding]; other site 536019012246 ATP-binding site [chemical binding]; other site 536019012247 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 536019012248 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 536019012249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019012250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019012251 metal binding site [ion binding]; metal-binding site 536019012252 active site 536019012253 I-site; other site 536019012254 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019012255 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 536019012256 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536019012257 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 536019012258 Predicted membrane protein [Function unknown]; Region: COG4420 536019012259 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 536019012260 NAD synthetase; Provisional; Region: PRK13981 536019012261 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 536019012262 multimer interface [polypeptide binding]; other site 536019012263 active site 536019012264 catalytic triad [active] 536019012265 protein interface 1 [polypeptide binding]; other site 536019012266 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 536019012267 homodimer interface [polypeptide binding]; other site 536019012268 NAD binding pocket [chemical binding]; other site 536019012269 ATP binding pocket [chemical binding]; other site 536019012270 Mg binding site [ion binding]; other site 536019012271 active-site loop [active] 536019012272 RibD C-terminal domain; Region: RibD_C; cl17279 536019012273 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019012274 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019012275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019012276 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 536019012277 Walker A/P-loop; other site 536019012278 ATP binding site [chemical binding]; other site 536019012279 Q-loop/lid; other site 536019012280 ABC transporter signature motif; other site 536019012281 Walker B; other site 536019012282 D-loop; other site 536019012283 H-loop/switch region; other site 536019012284 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 536019012285 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 536019012286 HIGH motif; other site 536019012287 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 536019012288 active site 536019012289 KMSKS motif; other site 536019012290 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 536019012291 malic enzyme; Reviewed; Region: PRK12862 536019012292 Malic enzyme, N-terminal domain; Region: malic; pfam00390 536019012293 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 536019012294 putative NAD(P) binding site [chemical binding]; other site 536019012295 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 536019012296 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 536019012297 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019012298 putative NAD(P) binding site [chemical binding]; other site 536019012299 putative active site [active] 536019012300 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 536019012301 putative active site [active] 536019012302 putative metal binding site [ion binding]; other site 536019012303 MFS_1 like family; Region: MFS_1_like; pfam12832 536019012304 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 536019012305 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 536019012306 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 536019012307 active site 536019012308 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 536019012309 Permease; Region: Permease; pfam02405 536019012310 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 536019012311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019012312 Walker A/P-loop; other site 536019012313 ATP binding site [chemical binding]; other site 536019012314 Q-loop/lid; other site 536019012315 ABC transporter signature motif; other site 536019012316 Walker B; other site 536019012317 D-loop; other site 536019012318 H-loop/switch region; other site 536019012319 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 536019012320 mce related protein; Region: MCE; pfam02470 536019012321 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 536019012322 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 536019012323 active site 536019012324 catalytic site [active] 536019012325 substrate binding site [chemical binding]; other site 536019012326 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 536019012327 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 536019012328 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 536019012329 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 536019012330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019012331 catalytic loop [active] 536019012332 iron binding site [ion binding]; other site 536019012333 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 536019012334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019012335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019012336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019012337 putative substrate translocation pore; other site 536019012338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019012339 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 536019012340 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 536019012341 dihydropteroate synthase; Region: DHPS; TIGR01496 536019012342 substrate binding pocket [chemical binding]; other site 536019012343 dimer interface [polypeptide binding]; other site 536019012344 inhibitor binding site; inhibition site 536019012345 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 536019012346 homooctamer interface [polypeptide binding]; other site 536019012347 active site 536019012348 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 536019012349 catalytic center binding site [active] 536019012350 ATP binding site [chemical binding]; other site 536019012351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 536019012352 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 536019012353 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 536019012354 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 536019012355 TrkA-N domain; Region: TrkA_N; pfam02254 536019012356 Predicted membrane protein [Function unknown]; Region: COG3768 536019012357 Domain of unknown function (DUF697); Region: DUF697; cl12064 536019012358 YcjX-like family, DUF463; Region: DUF463; cl01193 536019012359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019012360 catalytic core [active] 536019012361 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 536019012362 PAS domain; Region: PAS; smart00091 536019012363 PAS domain; Region: PAS_9; pfam13426 536019012364 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019012365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 536019012366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019012367 dimer interface [polypeptide binding]; other site 536019012368 phosphorylation site [posttranslational modification] 536019012369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019012370 ATP binding site [chemical binding]; other site 536019012371 Mg2+ binding site [ion binding]; other site 536019012372 G-X-G motif; other site 536019012373 Response regulator receiver domain; Region: Response_reg; pfam00072 536019012374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019012375 active site 536019012376 phosphorylation site [posttranslational modification] 536019012377 intermolecular recognition site; other site 536019012378 dimerization interface [polypeptide binding]; other site 536019012379 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 536019012380 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 536019012381 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 536019012382 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 536019012383 dimer interface [polypeptide binding]; other site 536019012384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019012385 active site 536019012386 metal binding site [ion binding]; metal-binding site 536019012387 glutathione binding site [chemical binding]; other site 536019012388 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 536019012389 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 536019012390 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019012391 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019012392 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 536019012393 putative ligand binding site [chemical binding]; other site 536019012394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019012395 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019012396 TM-ABC transporter signature motif; other site 536019012397 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019012398 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019012399 TM-ABC transporter signature motif; other site 536019012400 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 536019012401 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019012402 Walker A/P-loop; other site 536019012403 ATP binding site [chemical binding]; other site 536019012404 Q-loop/lid; other site 536019012405 ABC transporter signature motif; other site 536019012406 Walker B; other site 536019012407 D-loop; other site 536019012408 H-loop/switch region; other site 536019012409 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 536019012410 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019012411 Walker A/P-loop; other site 536019012412 ATP binding site [chemical binding]; other site 536019012413 Q-loop/lid; other site 536019012414 ABC transporter signature motif; other site 536019012415 Walker B; other site 536019012416 D-loop; other site 536019012417 H-loop/switch region; other site 536019012418 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019012419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019012420 metal binding site [ion binding]; metal-binding site 536019012421 active site 536019012422 I-site; other site 536019012423 Uncharacterized conserved protein [Function unknown]; Region: COG1801 536019012424 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 536019012425 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 536019012426 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 536019012427 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 536019012428 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 536019012429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 536019012430 oligomer interface [polypeptide binding]; other site 536019012431 active site residues [active] 536019012432 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 536019012433 putative hydrophobic ligand binding site [chemical binding]; other site 536019012434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019012435 dimerization interface [polypeptide binding]; other site 536019012436 putative DNA binding site [nucleotide binding]; other site 536019012437 putative Zn2+ binding site [ion binding]; other site 536019012438 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 536019012439 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 536019012440 dimer interface [polypeptide binding]; other site 536019012441 ssDNA binding site [nucleotide binding]; other site 536019012442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019012443 OsmC-like protein; Region: OsmC; cl00767 536019012444 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 536019012445 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019012446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019012447 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 536019012448 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 536019012449 CAP-like domain; other site 536019012450 active site 536019012451 primary dimer interface [polypeptide binding]; other site 536019012452 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019012453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019012454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019012455 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019012456 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019012457 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 536019012458 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 536019012459 active site 536019012460 (T/H)XGH motif; other site 536019012461 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 536019012462 active site 536019012463 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 536019012464 active site 536019012465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 536019012466 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 536019012467 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 536019012468 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 536019012469 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 536019012470 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019012471 AsnC family; Region: AsnC_trans_reg; pfam01037 536019012472 Uncharacterized conserved protein [Function unknown]; Region: COG2308 536019012473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 536019012474 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 536019012475 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 536019012476 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 536019012477 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 536019012478 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 536019012479 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 536019012480 tyrosine decarboxylase; Region: PLN02880 536019012481 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 536019012482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019012483 catalytic residue [active] 536019012484 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019012485 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536019012486 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019012487 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 536019012488 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019012489 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 536019012490 Walker A/P-loop; other site 536019012491 ATP binding site [chemical binding]; other site 536019012492 Q-loop/lid; other site 536019012493 ABC transporter signature motif; other site 536019012494 Walker B; other site 536019012495 D-loop; other site 536019012496 H-loop/switch region; other site 536019012497 TOBE domain; Region: TOBE_2; pfam08402 536019012498 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019012499 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 536019012500 Walker A/P-loop; other site 536019012501 ATP binding site [chemical binding]; other site 536019012502 Q-loop/lid; other site 536019012503 ABC transporter signature motif; other site 536019012504 Walker B; other site 536019012505 D-loop; other site 536019012506 H-loop/switch region; other site 536019012507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012508 dimer interface [polypeptide binding]; other site 536019012509 conserved gate region; other site 536019012510 putative PBP binding loops; other site 536019012511 ABC-ATPase subunit interface; other site 536019012512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019012513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012514 dimer interface [polypeptide binding]; other site 536019012515 conserved gate region; other site 536019012516 putative PBP binding loops; other site 536019012517 ABC-ATPase subunit interface; other site 536019012518 Predicted small integral membrane protein [Function unknown]; Region: COG5477 536019012519 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019012520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019012521 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 536019012522 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 536019012523 N- and C-terminal domain interface [polypeptide binding]; other site 536019012524 active site 536019012525 MgATP binding site [chemical binding]; other site 536019012526 catalytic site [active] 536019012527 metal binding site [ion binding]; metal-binding site 536019012528 glycerol binding site [chemical binding]; other site 536019012529 homotetramer interface [polypeptide binding]; other site 536019012530 homodimer interface [polypeptide binding]; other site 536019012531 FBP binding site [chemical binding]; other site 536019012532 protein IIAGlc interface [polypeptide binding]; other site 536019012533 BA14K-like protein; Region: BA14K; pfam07886 536019012534 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019012535 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 536019012536 putative ADP-binding pocket [chemical binding]; other site 536019012537 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 536019012538 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 536019012539 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 536019012540 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 536019012541 active site 536019012542 homotetramer interface [polypeptide binding]; other site 536019012543 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 536019012544 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 536019012545 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 536019012546 DNA protecting protein DprA; Region: dprA; TIGR00732 536019012547 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 536019012548 dihydroorotase; Validated; Region: PRK09059 536019012549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019012550 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 536019012551 active site 536019012552 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 536019012553 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536019012554 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536019012555 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 536019012556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019012557 FAD binding site [chemical binding]; other site 536019012558 substrate binding site [chemical binding]; other site 536019012559 catalytic residues [active] 536019012560 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 536019012561 metal-dependent hydrolase; Provisional; Region: PRK00685 536019012562 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 536019012563 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 536019012564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019012565 Coenzyme A binding pocket [chemical binding]; other site 536019012566 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019012567 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 536019012568 Uncharacterized conserved protein [Function unknown]; Region: COG1434 536019012569 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536019012570 putative active site [active] 536019012571 Predicted membrane protein [Function unknown]; Region: COG3821 536019012572 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 536019012573 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 536019012574 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 536019012575 Uncharacterized conserved protein [Function unknown]; Region: COG5458 536019012576 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019012577 HSP70 interaction site [polypeptide binding]; other site 536019012578 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536019012579 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 536019012580 Sporulation related domain; Region: SPOR; pfam05036 536019012581 Phasin protein; Region: Phasin_2; pfam09361 536019012582 Uncharacterized conserved protein [Function unknown]; Region: COG2127 536019012583 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 536019012584 Clp amino terminal domain; Region: Clp_N; pfam02861 536019012585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019012586 Walker A motif; other site 536019012587 ATP binding site [chemical binding]; other site 536019012588 Walker B motif; other site 536019012589 arginine finger; other site 536019012590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019012591 Walker A motif; other site 536019012592 ATP binding site [chemical binding]; other site 536019012593 Walker B motif; other site 536019012594 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 536019012595 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 536019012596 P-loop motif; other site 536019012597 ATP binding site [chemical binding]; other site 536019012598 Chloramphenicol (Cm) binding site [chemical binding]; other site 536019012599 catalytic residue [active] 536019012600 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 536019012601 active site 536019012602 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 536019012603 HIT family signature motif; other site 536019012604 catalytic residue [active] 536019012605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 536019012606 Protein of unknown function, DUF482; Region: DUF482; pfam04339 536019012607 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 536019012608 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 536019012609 putative active site [active] 536019012610 catalytic site [active] 536019012611 putative metal binding site [ion binding]; other site 536019012612 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 536019012613 homotrimer interaction site [polypeptide binding]; other site 536019012614 putative active site [active] 536019012615 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 536019012616 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 536019012617 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019012618 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 536019012619 rRNA interaction site [nucleotide binding]; other site 536019012620 S8 interaction site; other site 536019012621 putative laminin-1 binding site; other site 536019012622 elongation factor Ts; Provisional; Region: tsf; PRK09377 536019012623 UBA/TS-N domain; Region: UBA; pfam00627 536019012624 Elongation factor TS; Region: EF_TS; pfam00889 536019012625 Elongation factor TS; Region: EF_TS; pfam00889 536019012626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019012627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019012628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536019012629 putative effector binding pocket; other site 536019012630 putative dimerization interface [polypeptide binding]; other site 536019012631 SnoaL-like domain; Region: SnoaL_4; pfam13577 536019012632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019012633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019012634 active site 536019012635 catalytic tetrad [active] 536019012636 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 536019012637 putative nucleotide binding site [chemical binding]; other site 536019012638 uridine monophosphate binding site [chemical binding]; other site 536019012639 homohexameric interface [polypeptide binding]; other site 536019012640 ribosome recycling factor; Reviewed; Region: frr; PRK00083 536019012641 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 536019012642 hinge region; other site 536019012643 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 536019012644 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 536019012645 catalytic residue [active] 536019012646 putative FPP diphosphate binding site; other site 536019012647 putative FPP binding hydrophobic cleft; other site 536019012648 dimer interface [polypeptide binding]; other site 536019012649 putative IPP diphosphate binding site; other site 536019012650 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 536019012651 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 536019012652 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 536019012653 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 536019012654 active site 536019012655 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 536019012656 protein binding site [polypeptide binding]; other site 536019012657 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 536019012658 putative substrate binding region [chemical binding]; other site 536019012659 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 536019012660 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 536019012661 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536019012662 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536019012663 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536019012664 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536019012665 Surface antigen; Region: Bac_surface_Ag; pfam01103 536019012666 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 536019012667 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 536019012668 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 536019012669 trimer interface [polypeptide binding]; other site 536019012670 active site 536019012671 UDP-GlcNAc binding site [chemical binding]; other site 536019012672 lipid binding site [chemical binding]; lipid-binding site 536019012673 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 536019012674 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 536019012675 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 536019012676 active site 536019012677 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 536019012678 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 536019012679 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 536019012680 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 536019012681 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 536019012682 dimer interface [polypeptide binding]; other site 536019012683 active site 536019012684 citrylCoA binding site [chemical binding]; other site 536019012685 NADH binding [chemical binding]; other site 536019012686 cationic pore residues; other site 536019012687 oxalacetate/citrate binding site [chemical binding]; other site 536019012688 coenzyme A binding site [chemical binding]; other site 536019012689 catalytic triad [active] 536019012690 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 536019012691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536019012692 active site 536019012693 HIGH motif; other site 536019012694 nucleotide binding site [chemical binding]; other site 536019012695 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 536019012696 active site 536019012697 KMSKS motif; other site 536019012698 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 536019012699 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 536019012700 Competence protein; Region: Competence; pfam03772 536019012701 LexA repressor; Validated; Region: PRK00215 536019012702 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 536019012703 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536019012704 Catalytic site [active] 536019012705 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536019012706 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 536019012707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019012708 catalytic residue [active] 536019012709 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019012710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019012711 DNA-binding site [nucleotide binding]; DNA binding site 536019012712 FCD domain; Region: FCD; pfam07729 536019012713 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 536019012714 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019012715 zinc binding site [ion binding]; other site 536019012716 putative ligand binding site [chemical binding]; other site 536019012717 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 536019012718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019012719 Walker A/P-loop; other site 536019012720 ATP binding site [chemical binding]; other site 536019012721 Q-loop/lid; other site 536019012722 ABC transporter signature motif; other site 536019012723 Walker B; other site 536019012724 D-loop; other site 536019012725 H-loop/switch region; other site 536019012726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019012727 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 536019012728 TM-ABC transporter signature motif; other site 536019012729 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 536019012730 kynureninase; Region: kynureninase; TIGR01814 536019012731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019012732 catalytic residue [active] 536019012733 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 536019012734 2-aminobenzoate-CoA ligase (ABCL); Region: ABCL; cd05958 536019012735 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 536019012736 putative dimer interface [polypeptide binding]; other site 536019012737 acyl-activating enzyme (AAE) consensus motif; other site 536019012738 putative active site [active] 536019012739 putative AMP binding site [chemical binding]; other site 536019012740 putative CoA binding site [chemical binding]; other site 536019012741 putative chemical substrate binding site [chemical binding]; other site 536019012742 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 536019012743 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 536019012744 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 536019012745 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 536019012746 dimer interface [polypeptide binding]; other site 536019012747 putative functional site; other site 536019012748 putative MPT binding site; other site 536019012749 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 536019012750 trimer interface [polypeptide binding]; other site 536019012751 dimer interface [polypeptide binding]; other site 536019012752 putative active site [active] 536019012753 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 536019012754 active site 536019012755 ribulose/triose binding site [chemical binding]; other site 536019012756 phosphate binding site [ion binding]; other site 536019012757 substrate (anthranilate) binding pocket [chemical binding]; other site 536019012758 product (indole) binding pocket [chemical binding]; other site 536019012759 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 536019012760 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 536019012761 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 536019012762 SurA N-terminal domain; Region: SurA_N_3; cl07813 536019012763 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 536019012764 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 536019012765 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 536019012766 triosephosphate isomerase; Provisional; Region: PRK14565 536019012767 substrate binding site [chemical binding]; other site 536019012768 dimer interface [polypeptide binding]; other site 536019012769 catalytic triad [active] 536019012770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019012771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019012772 CTP synthetase; Validated; Region: pyrG; PRK05380 536019012773 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 536019012774 Catalytic site [active] 536019012775 active site 536019012776 UTP binding site [chemical binding]; other site 536019012777 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 536019012778 active site 536019012779 putative oxyanion hole; other site 536019012780 catalytic triad [active] 536019012781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 536019012782 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 536019012783 Na binding site [ion binding]; other site 536019012784 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019012785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019012786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019012787 dimerization interface [polypeptide binding]; other site 536019012788 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 536019012789 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 536019012790 interface (dimer of trimers) [polypeptide binding]; other site 536019012791 Substrate-binding/catalytic site; other site 536019012792 Zn-binding sites [ion binding]; other site 536019012793 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 536019012794 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019012795 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 536019012796 peptide binding site [polypeptide binding]; other site 536019012797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019012798 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536019012799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012800 dimer interface [polypeptide binding]; other site 536019012801 conserved gate region; other site 536019012802 putative PBP binding loops; other site 536019012803 ABC-ATPase subunit interface; other site 536019012804 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019012805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012806 dimer interface [polypeptide binding]; other site 536019012807 conserved gate region; other site 536019012808 putative PBP binding loops; other site 536019012809 ABC-ATPase subunit interface; other site 536019012810 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 536019012811 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019012812 Walker A/P-loop; other site 536019012813 ATP binding site [chemical binding]; other site 536019012814 Q-loop/lid; other site 536019012815 ABC transporter signature motif; other site 536019012816 Walker B; other site 536019012817 D-loop; other site 536019012818 H-loop/switch region; other site 536019012819 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019012820 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 536019012821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019012822 Walker A/P-loop; other site 536019012823 ATP binding site [chemical binding]; other site 536019012824 Q-loop/lid; other site 536019012825 ABC transporter signature motif; other site 536019012826 Walker B; other site 536019012827 D-loop; other site 536019012828 H-loop/switch region; other site 536019012829 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536019012830 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019012831 transcriptional regulator; Provisional; Region: PRK10632 536019012832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019012833 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019012834 putative effector binding pocket; other site 536019012835 dimerization interface [polypeptide binding]; other site 536019012836 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019012837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019012838 putative substrate translocation pore; other site 536019012839 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 536019012840 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019012841 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 536019012842 ligand binding site [chemical binding]; other site 536019012843 flexible hinge region; other site 536019012844 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 536019012845 putative switch regulator; other site 536019012846 non-specific DNA interactions [nucleotide binding]; other site 536019012847 DNA binding site [nucleotide binding] 536019012848 sequence specific DNA binding site [nucleotide binding]; other site 536019012849 putative cAMP binding site [chemical binding]; other site 536019012850 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 536019012851 tetramer interface [polypeptide binding]; other site 536019012852 dimer interface [polypeptide binding]; other site 536019012853 circadian clock protein KaiC; Reviewed; Region: PRK09302 536019012854 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 536019012855 Walker A motif; other site 536019012856 ATP binding site [chemical binding]; other site 536019012857 Walker B motif; other site 536019012858 recA bacterial DNA recombination protein; Region: RecA; cl17211 536019012859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 536019012860 Walker A motif; other site 536019012861 ATP binding site [chemical binding]; other site 536019012862 Walker B motif; other site 536019012863 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 536019012864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 536019012865 dimer interface [polypeptide binding]; other site 536019012866 phosphorylation site [posttranslational modification] 536019012867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019012868 ATP binding site [chemical binding]; other site 536019012869 Mg2+ binding site [ion binding]; other site 536019012870 G-X-G motif; other site 536019012871 SPW repeat; Region: SPW; pfam03779 536019012872 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 536019012873 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019012874 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 536019012875 putative dimer interface [polypeptide binding]; other site 536019012876 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019012877 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536019012878 putative dimer interface [polypeptide binding]; other site 536019012879 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 536019012880 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019012881 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019012882 protein binding site [polypeptide binding]; other site 536019012883 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019012884 protein binding site [polypeptide binding]; other site 536019012885 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 536019012886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019012887 putative ADP-binding pocket [chemical binding]; other site 536019012888 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 536019012889 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 536019012890 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019012891 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 536019012892 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 536019012893 Preprotein translocase subunit; Region: YajC; cl00806 536019012894 MAPEG family; Region: MAPEG; pfam01124 536019012895 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019012896 active site 536019012897 metal binding site [ion binding]; metal-binding site 536019012898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019012899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019012900 S-adenosylmethionine binding site [chemical binding]; other site 536019012901 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 536019012902 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 536019012903 active site 536019012904 DNA binding site [nucleotide binding] 536019012905 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 536019012906 DNA binding site [nucleotide binding] 536019012907 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 536019012908 Low affinity iron permease; Region: Iron_permease; cl12096 536019012909 Predicted integral membrane protein [Function unknown]; Region: COG5528 536019012910 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 536019012911 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536019012912 putative NAD(P) binding site [chemical binding]; other site 536019012913 active site 536019012914 DoxX-like family; Region: DoxX_3; pfam13781 536019012915 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 536019012916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019012917 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019012918 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 536019012919 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019012920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019012921 dimer interface [polypeptide binding]; other site 536019012922 conserved gate region; other site 536019012923 putative PBP binding loops; other site 536019012924 ABC-ATPase subunit interface; other site 536019012925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 536019012926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019012927 Walker A/P-loop; other site 536019012928 ATP binding site [chemical binding]; other site 536019012929 Q-loop/lid; other site 536019012930 ABC transporter signature motif; other site 536019012931 Walker B; other site 536019012932 D-loop; other site 536019012933 H-loop/switch region; other site 536019012934 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019012935 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 536019012936 ligand binding site [chemical binding]; other site 536019012937 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 536019012938 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 536019012939 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 536019012940 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 536019012941 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 536019012942 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536019012943 Walker A/P-loop; other site 536019012944 ATP binding site [chemical binding]; other site 536019012945 Q-loop/lid; other site 536019012946 ABC transporter signature motif; other site 536019012947 Walker B; other site 536019012948 D-loop; other site 536019012949 H-loop/switch region; other site 536019012950 ABC-2 type transporter; Region: ABC2_membrane; cl17235 536019012951 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 536019012952 Cytochrome c; Region: Cytochrom_C; pfam00034 536019012953 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 536019012954 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 536019012955 Subunit I/III interface [polypeptide binding]; other site 536019012956 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536019012957 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 536019012958 D-pathway; other site 536019012959 Putative ubiquinol binding site [chemical binding]; other site 536019012960 Low-spin heme (heme b) binding site [chemical binding]; other site 536019012961 Putative water exit pathway; other site 536019012962 Binuclear center (heme o3/CuB) [ion binding]; other site 536019012963 K-pathway; other site 536019012964 Putative proton exit pathway; other site 536019012965 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 536019012966 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536019012967 Cytochrome c; Region: Cytochrom_C; pfam00034 536019012968 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 536019012969 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 536019012970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019012971 substrate binding pocket [chemical binding]; other site 536019012972 membrane-bound complex binding site; other site 536019012973 hinge residues; other site 536019012974 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 536019012975 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 536019012976 Trp docking motif [polypeptide binding]; other site 536019012977 dimer interface [polypeptide binding]; other site 536019012978 active site 536019012979 small subunit binding site [polypeptide binding]; other site 536019012980 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 536019012981 dimanganese center [ion binding]; other site 536019012982 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 536019012983 putative active site [active] 536019012984 putative metal binding site [ion binding]; other site 536019012985 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019012986 GAF domain; Region: GAF; pfam01590 536019012987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019012988 GAF domain; Region: GAF; pfam01590 536019012989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019012990 PAS fold; Region: PAS_3; pfam08447 536019012991 putative active site [active] 536019012992 heme pocket [chemical binding]; other site 536019012993 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019012994 GAF domain; Region: GAF; pfam01590 536019012995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019012996 dimer interface [polypeptide binding]; other site 536019012997 phosphorylation site [posttranslational modification] 536019012998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019012999 ATP binding site [chemical binding]; other site 536019013000 Mg2+ binding site [ion binding]; other site 536019013001 G-X-G motif; other site 536019013002 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019013003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019013004 active site 536019013005 phosphorylation site [posttranslational modification] 536019013006 intermolecular recognition site; other site 536019013007 dimerization interface [polypeptide binding]; other site 536019013008 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 536019013009 putative catalytic site [active] 536019013010 putative phosphate binding site [ion binding]; other site 536019013011 active site 536019013012 metal binding site A [ion binding]; metal-binding site 536019013013 DNA binding site [nucleotide binding] 536019013014 putative AP binding site [nucleotide binding]; other site 536019013015 putative metal binding site B [ion binding]; other site 536019013016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019013017 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536019013018 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536019013019 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 536019013020 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 536019013021 Subunit I/III interface [polypeptide binding]; other site 536019013022 Subunit III/IV interface [polypeptide binding]; other site 536019013023 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536019013024 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 536019013025 D-pathway; other site 536019013026 Putative ubiquinol binding site [chemical binding]; other site 536019013027 Low-spin heme (heme b) binding site [chemical binding]; other site 536019013028 Putative water exit pathway; other site 536019013029 Binuclear center (heme o3/CuB) [ion binding]; other site 536019013030 K-pathway; other site 536019013031 Putative proton exit pathway; other site 536019013032 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 536019013033 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536019013034 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 536019013035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019013036 S-adenosylmethionine binding site [chemical binding]; other site 536019013037 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 536019013038 PAS fold; Region: PAS_3; pfam08447 536019013039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019013040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019013041 metal binding site [ion binding]; metal-binding site 536019013042 active site 536019013043 I-site; other site 536019013044 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019013045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013046 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013047 putative active site [active] 536019013048 heme pocket [chemical binding]; other site 536019013049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013050 putative active site [active] 536019013051 heme pocket [chemical binding]; other site 536019013052 PAS domain S-box; Region: sensory_box; TIGR00229 536019013053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013054 putative active site [active] 536019013055 heme pocket [chemical binding]; other site 536019013056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019013057 HWE histidine kinase; Region: HWE_HK; pfam07536 536019013058 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 536019013059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019013060 putative substrate translocation pore; other site 536019013061 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 536019013062 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 536019013063 active site 536019013064 substrate binding site [chemical binding]; other site 536019013065 activation loop (A-loop); other site 536019013066 AAA ATPase domain; Region: AAA_16; pfam13191 536019013067 Predicted ATPase [General function prediction only]; Region: COG3899 536019013068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019013069 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536019013070 PAS domain S-box; Region: sensory_box; TIGR00229 536019013071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013072 putative active site [active] 536019013073 heme pocket [chemical binding]; other site 536019013074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013075 dimer interface [polypeptide binding]; other site 536019013076 phosphorylation site [posttranslational modification] 536019013077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013078 ATP binding site [chemical binding]; other site 536019013079 Mg2+ binding site [ion binding]; other site 536019013080 G-X-G motif; other site 536019013081 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 536019013082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019013083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013084 dimer interface [polypeptide binding]; other site 536019013085 conserved gate region; other site 536019013086 putative PBP binding loops; other site 536019013087 ABC-ATPase subunit interface; other site 536019013088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013089 dimer interface [polypeptide binding]; other site 536019013090 conserved gate region; other site 536019013091 putative PBP binding loops; other site 536019013092 ABC-ATPase subunit interface; other site 536019013093 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019013094 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019013095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019013096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019013097 DNA binding site [nucleotide binding] 536019013098 domain linker motif; other site 536019013099 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019013100 dimerization interface [polypeptide binding]; other site 536019013101 ligand binding site [chemical binding]; other site 536019013102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019013103 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 536019013104 [2Fe-2S] cluster binding site [ion binding]; other site 536019013105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 536019013106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019013107 Epoxide hydrolase N terminus; Region: EHN; pfam06441 536019013108 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019013109 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 536019013110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013111 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013112 putative active site [active] 536019013113 heme pocket [chemical binding]; other site 536019013114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013115 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013116 putative active site [active] 536019013117 heme pocket [chemical binding]; other site 536019013118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013119 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013120 putative active site [active] 536019013121 heme pocket [chemical binding]; other site 536019013122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013123 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013124 putative active site [active] 536019013125 heme pocket [chemical binding]; other site 536019013126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013127 putative active site [active] 536019013128 heme pocket [chemical binding]; other site 536019013129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019013130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013131 dimer interface [polypeptide binding]; other site 536019013132 phosphorylation site [posttranslational modification] 536019013133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013134 ATP binding site [chemical binding]; other site 536019013135 Mg2+ binding site [ion binding]; other site 536019013136 G-X-G motif; other site 536019013137 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 536019013138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013139 PAS fold; Region: PAS_3; pfam08447 536019013140 putative active site [active] 536019013141 heme pocket [chemical binding]; other site 536019013142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013143 PAS fold; Region: PAS_3; pfam08447 536019013144 putative active site [active] 536019013145 heme pocket [chemical binding]; other site 536019013146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536019013147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019013148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 536019013149 dimer interface [polypeptide binding]; other site 536019013150 phosphorylation site [posttranslational modification] 536019013151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013152 ATP binding site [chemical binding]; other site 536019013153 Mg2+ binding site [ion binding]; other site 536019013154 G-X-G motif; other site 536019013155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019013156 Response regulator receiver domain; Region: Response_reg; pfam00072 536019013157 active site 536019013158 phosphorylation site [posttranslational modification] 536019013159 intermolecular recognition site; other site 536019013160 dimerization interface [polypeptide binding]; other site 536019013161 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 536019013162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019013163 active site 536019013164 phosphorylation site [posttranslational modification] 536019013165 intermolecular recognition site; other site 536019013166 dimerization interface [polypeptide binding]; other site 536019013167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019013168 DNA binding residues [nucleotide binding] 536019013169 dimerization interface [polypeptide binding]; other site 536019013170 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 536019013171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019013172 substrate binding site [chemical binding]; other site 536019013173 oxyanion hole (OAH) forming residues; other site 536019013174 trimer interface [polypeptide binding]; other site 536019013175 fumarate hydratase; Reviewed; Region: fumC; PRK00485 536019013176 Class II fumarases; Region: Fumarase_classII; cd01362 536019013177 active site 536019013178 tetramer interface [polypeptide binding]; other site 536019013179 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 536019013180 amphipathic channel; other site 536019013181 Asn-Pro-Ala signature motifs; other site 536019013182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019013183 putative substrate translocation pore; other site 536019013184 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019013185 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536019013186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019013187 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019013188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019013189 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 536019013190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019013191 Epoxide hydrolase N terminus; Region: EHN; pfam06441 536019013192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019013193 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019013194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 536019013195 MOSC domain; Region: MOSC; pfam03473 536019013196 3-alpha domain; Region: 3-alpha; pfam03475 536019013197 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 536019013198 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 536019013199 FAD binding pocket [chemical binding]; other site 536019013200 FAD binding motif [chemical binding]; other site 536019013201 phosphate binding motif [ion binding]; other site 536019013202 beta-alpha-beta structure motif; other site 536019013203 NAD binding pocket [chemical binding]; other site 536019013204 Heme binding pocket [chemical binding]; other site 536019013205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019013206 catalytic loop [active] 536019013207 iron binding site [ion binding]; other site 536019013208 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 536019013209 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 536019013210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013211 ATP binding site [chemical binding]; other site 536019013212 Mg2+ binding site [ion binding]; other site 536019013213 G-X-G motif; other site 536019013214 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 536019013215 gating phenylalanine in ion channel; other site 536019013216 Domain of unknown function (DUF336); Region: DUF336; pfam03928 536019013217 enoyl-CoA hydratase; Provisional; Region: PRK06688 536019013218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019013219 substrate binding site [chemical binding]; other site 536019013220 oxyanion hole (OAH) forming residues; other site 536019013221 trimer interface [polypeptide binding]; other site 536019013222 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 536019013223 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 536019013224 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 536019013225 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 536019013226 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 536019013227 dimerization interface [polypeptide binding]; other site 536019013228 DPS ferroxidase diiron center [ion binding]; other site 536019013229 ion pore; other site 536019013230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019013231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013232 Mg2+ binding site [ion binding]; other site 536019013233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019013234 classical (c) SDRs; Region: SDR_c; cd05233 536019013235 NAD(P) binding site [chemical binding]; other site 536019013236 active site 536019013237 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 536019013238 active site 1 [active] 536019013239 dimer interface [polypeptide binding]; other site 536019013240 hexamer interface [polypeptide binding]; other site 536019013241 active site 2 [active] 536019013242 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019013243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 536019013244 active site 536019013245 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019013246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019013247 substrate binding pocket [chemical binding]; other site 536019013248 membrane-bound complex binding site; other site 536019013249 hinge residues; other site 536019013250 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019013251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013252 putative active site [active] 536019013253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019013254 heme pocket [chemical binding]; other site 536019013255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013256 dimer interface [polypeptide binding]; other site 536019013257 phosphorylation site [posttranslational modification] 536019013258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013259 ATP binding site [chemical binding]; other site 536019013260 Mg2+ binding site [ion binding]; other site 536019013261 G-X-G motif; other site 536019013262 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019013263 Caspase domain; Region: Peptidase_C14; pfam00656 536019013264 proteolytic cleavage site; other site 536019013265 dimer interface [polypeptide binding]; other site 536019013266 substrate pocket [chemical binding]; other site 536019013267 Conjugal transfer protein TraD; Region: TraD; pfam06412 536019013268 Conjugal transfer protein TraD; Region: TraD; pfam06412 536019013269 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 536019013270 MobA/MobL family; Region: MobA_MobL; pfam03389 536019013271 AAA domain; Region: AAA_30; pfam13604 536019013272 Family description; Region: UvrD_C_2; pfam13538 536019013273 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 536019013274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 536019013275 non-specific DNA binding site [nucleotide binding]; other site 536019013276 salt bridge; other site 536019013277 sequence-specific DNA binding site [nucleotide binding]; other site 536019013278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536019013279 active site 536019013280 DNA binding site [nucleotide binding] 536019013281 Int/Topo IB signature motif; other site 536019013282 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 536019013283 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 536019013284 FMN binding site [chemical binding]; other site 536019013285 active site 536019013286 catalytic residues [active] 536019013287 substrate binding site [chemical binding]; other site 536019013288 Predicted aspartyl protease [General function prediction only]; Region: COG3577 536019013289 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 536019013290 catalytic motif [active] 536019013291 Catalytic residue [active] 536019013292 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 536019013293 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 536019013294 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 536019013295 putative dimer interface [polypeptide binding]; other site 536019013296 active site pocket [active] 536019013297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019013298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019013299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013300 dimer interface [polypeptide binding]; other site 536019013301 phosphorylation site [posttranslational modification] 536019013302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013303 ATP binding site [chemical binding]; other site 536019013304 Mg2+ binding site [ion binding]; other site 536019013305 G-X-G motif; other site 536019013306 Staphylococcal nuclease homologues; Region: SNc; smart00318 536019013307 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 536019013308 Catalytic site; other site 536019013309 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019013310 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 536019013311 putative C-terminal domain interface [polypeptide binding]; other site 536019013312 putative GSH binding site (G-site) [chemical binding]; other site 536019013313 putative dimer interface [polypeptide binding]; other site 536019013314 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 536019013315 putative N-terminal domain interface [polypeptide binding]; other site 536019013316 putative dimer interface [polypeptide binding]; other site 536019013317 putative substrate binding pocket (H-site) [chemical binding]; other site 536019013318 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 536019013319 putative uracil binding site [chemical binding]; other site 536019013320 putative active site [active] 536019013321 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019013322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019013323 putative DNA binding site [nucleotide binding]; other site 536019013324 putative Zn2+ binding site [ion binding]; other site 536019013325 AsnC family; Region: AsnC_trans_reg; pfam01037 536019013326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 536019013327 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 536019013328 A new structural DNA glycosylase; Region: AlkD_like; cd06561 536019013329 active site 536019013330 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536019013331 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019013332 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019013333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013334 dimer interface [polypeptide binding]; other site 536019013335 conserved gate region; other site 536019013336 putative PBP binding loops; other site 536019013337 ABC-ATPase subunit interface; other site 536019013338 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019013339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013340 dimer interface [polypeptide binding]; other site 536019013341 conserved gate region; other site 536019013342 putative PBP binding loops; other site 536019013343 ABC-ATPase subunit interface; other site 536019013344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019013345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019013346 substrate binding pocket [chemical binding]; other site 536019013347 membrane-bound complex binding site; other site 536019013348 hinge residues; other site 536019013349 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 536019013350 Walker A motif; other site 536019013351 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 536019013352 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 536019013353 GTP binding site; other site 536019013354 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019013355 EamA-like transporter family; Region: EamA; pfam00892 536019013356 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 536019013357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019013358 FeS/SAM binding site; other site 536019013359 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 536019013360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 536019013361 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 536019013362 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536019013363 MarR family; Region: MarR_2; pfam12802 536019013364 MarR family; Region: MarR_2; cl17246 536019013365 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019013366 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 536019013367 active site 536019013368 catalytic residue [active] 536019013369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019013370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019013371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019013372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019013373 NAD(P) binding site [chemical binding]; other site 536019013374 active site 536019013375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 536019013376 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019013377 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 536019013378 phosphoglycolate phosphatase; Provisional; Region: PRK13222 536019013379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019013380 motif II; other site 536019013381 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 536019013382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536019013383 active site 536019013384 dimer interface [polypeptide binding]; other site 536019013385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 536019013386 glutathione reductase; Validated; Region: PRK06116 536019013387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019013388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019013389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019013390 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019013391 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 536019013392 MgtE intracellular N domain; Region: MgtE_N; pfam03448 536019013393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 536019013394 Divalent cation transporter; Region: MgtE; pfam01769 536019013395 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 536019013396 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 536019013397 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 536019013398 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 536019013399 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 536019013400 catalytic residues [active] 536019013401 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 536019013402 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 536019013403 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 536019013404 Uncharacterized conserved protein [Function unknown]; Region: COG3785 536019013405 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 536019013406 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019013407 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 536019013408 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 536019013409 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 536019013410 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 536019013411 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 536019013412 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 536019013413 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 536019013414 NADP binding site [chemical binding]; other site 536019013415 dimer interface [polypeptide binding]; other site 536019013416 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 536019013417 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019013418 Walker A/P-loop; other site 536019013419 ATP binding site [chemical binding]; other site 536019013420 Q-loop/lid; other site 536019013421 ABC transporter signature motif; other site 536019013422 Walker B; other site 536019013423 D-loop; other site 536019013424 H-loop/switch region; other site 536019013425 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019013426 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019013427 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019013428 TM-ABC transporter signature motif; other site 536019013429 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019013430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019013431 TM-ABC transporter signature motif; other site 536019013432 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 536019013433 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 536019013434 putative ligand binding site [chemical binding]; other site 536019013435 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019013436 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 536019013437 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 536019013438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019013439 FeS/SAM binding site; other site 536019013440 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 536019013441 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 536019013442 Uncharacterized conserved protein [Function unknown]; Region: COG5482 536019013443 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 536019013444 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 536019013445 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019013446 HSP70 interaction site [polypeptide binding]; other site 536019013447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019013448 putative DNA binding site [nucleotide binding]; other site 536019013449 dimerization interface [polypeptide binding]; other site 536019013450 putative Zn2+ binding site [ion binding]; other site 536019013451 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 536019013452 putative hydrophobic ligand binding site [chemical binding]; other site 536019013453 CLM binding site; other site 536019013454 L1 loop; other site 536019013455 DNA binding site [nucleotide binding] 536019013456 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 536019013457 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 536019013458 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 536019013459 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536019013460 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 536019013461 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 536019013462 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 536019013463 TMP-binding site; other site 536019013464 ATP-binding site [chemical binding]; other site 536019013465 DNA polymerase III subunit delta'; Validated; Region: PRK09112 536019013466 DNA polymerase III subunit delta'; Validated; Region: PRK08485 536019013467 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 536019013468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 536019013469 active site 536019013470 HIGH motif; other site 536019013471 KMSKS motif; other site 536019013472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 536019013473 tRNA binding surface [nucleotide binding]; other site 536019013474 anticodon binding site; other site 536019013475 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 536019013476 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 536019013477 active site 536019013478 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 536019013479 putative hydrolase; Provisional; Region: PRK02113 536019013480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019013481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019013482 Coenzyme A binding pocket [chemical binding]; other site 536019013483 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019013484 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019013485 dimer interface [polypeptide binding]; other site 536019013486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019013487 catalytic residue [active] 536019013488 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 536019013489 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 536019013490 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 536019013491 active site 536019013492 catalytic residues [active] 536019013493 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 536019013494 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 536019013495 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 536019013496 RNA polymerase sigma factor; Provisional; Region: PRK12511 536019013497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019013498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019013499 DNA binding residues [nucleotide binding] 536019013500 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 536019013501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019013502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019013503 homodimer interface [polypeptide binding]; other site 536019013504 catalytic residue [active] 536019013505 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 536019013506 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 536019013507 homodimer interface [polypeptide binding]; other site 536019013508 metal binding site [ion binding]; metal-binding site 536019013509 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 536019013510 homodimer interface [polypeptide binding]; other site 536019013511 active site 536019013512 putative chemical substrate binding site [chemical binding]; other site 536019013513 metal binding site [ion binding]; metal-binding site 536019013514 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 536019013515 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 536019013516 HflX GTPase family; Region: HflX; cd01878 536019013517 G1 box; other site 536019013518 GTP/Mg2+ binding site [chemical binding]; other site 536019013519 Switch I region; other site 536019013520 G2 box; other site 536019013521 G3 box; other site 536019013522 Switch II region; other site 536019013523 G4 box; other site 536019013524 G5 box; other site 536019013525 bacterial Hfq-like; Region: Hfq; cd01716 536019013526 hexamer interface [polypeptide binding]; other site 536019013527 Sm1 motif; other site 536019013528 RNA binding site [nucleotide binding]; other site 536019013529 Sm2 motif; other site 536019013530 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536019013531 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 536019013532 homodimer interface [polypeptide binding]; other site 536019013533 substrate-cofactor binding pocket; other site 536019013534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019013535 catalytic residue [active] 536019013536 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 536019013537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019013538 active site 536019013539 phosphorylation site [posttranslational modification] 536019013540 intermolecular recognition site; other site 536019013541 dimerization interface [polypeptide binding]; other site 536019013542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019013543 Walker A motif; other site 536019013544 ATP binding site [chemical binding]; other site 536019013545 Walker B motif; other site 536019013546 arginine finger; other site 536019013547 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019013548 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 536019013549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536019013550 dimerization interface [polypeptide binding]; other site 536019013551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019013552 putative active site [active] 536019013553 heme pocket [chemical binding]; other site 536019013554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013555 dimer interface [polypeptide binding]; other site 536019013556 phosphorylation site [posttranslational modification] 536019013557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013558 ATP binding site [chemical binding]; other site 536019013559 Mg2+ binding site [ion binding]; other site 536019013560 G-X-G motif; other site 536019013561 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 536019013562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019013563 active site 536019013564 phosphorylation site [posttranslational modification] 536019013565 intermolecular recognition site; other site 536019013566 dimerization interface [polypeptide binding]; other site 536019013567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019013568 Walker A motif; other site 536019013569 ATP binding site [chemical binding]; other site 536019013570 Walker B motif; other site 536019013571 arginine finger; other site 536019013572 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 536019013573 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 536019013574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019013575 dimer interface [polypeptide binding]; other site 536019013576 phosphorylation site [posttranslational modification] 536019013577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019013578 ATP binding site [chemical binding]; other site 536019013579 Mg2+ binding site [ion binding]; other site 536019013580 G-X-G motif; other site 536019013581 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 536019013582 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 536019013583 FMN binding site [chemical binding]; other site 536019013584 active site 536019013585 catalytic residues [active] 536019013586 substrate binding site [chemical binding]; other site 536019013587 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 536019013588 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 536019013589 substrate binding site; other site 536019013590 dimer interface; other site 536019013591 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 536019013592 homotrimer interaction site [polypeptide binding]; other site 536019013593 zinc binding site [ion binding]; other site 536019013594 CDP-binding sites; other site 536019013595 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 536019013596 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 536019013597 putative coenzyme Q binding site [chemical binding]; other site 536019013598 lipoyl synthase; Provisional; Region: PRK05481 536019013599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019013600 FeS/SAM binding site; other site 536019013601 Predicted membrane protein [Function unknown]; Region: COG2261 536019013602 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 536019013603 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 536019013604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019013605 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019013606 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 536019013607 active site 536019013608 catalytic triad [active] 536019013609 oxyanion hole [active] 536019013610 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019013611 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 536019013612 E3 interaction surface; other site 536019013613 lipoyl attachment site [posttranslational modification]; other site 536019013614 e3 binding domain; Region: E3_binding; pfam02817 536019013615 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536019013616 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 536019013617 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536019013618 E3 interaction surface; other site 536019013619 lipoyl attachment site [posttranslational modification]; other site 536019013620 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 536019013621 alpha subunit interface [polypeptide binding]; other site 536019013622 TPP binding site [chemical binding]; other site 536019013623 heterodimer interface [polypeptide binding]; other site 536019013624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019013625 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 536019013626 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 536019013627 tetramer interface [polypeptide binding]; other site 536019013628 TPP-binding site [chemical binding]; other site 536019013629 heterodimer interface [polypeptide binding]; other site 536019013630 phosphorylation loop region [posttranslational modification] 536019013631 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 536019013632 Septum formation initiator; Region: DivIC; pfam04977 536019013633 enolase; Provisional; Region: eno; PRK00077 536019013634 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 536019013635 dimer interface [polypeptide binding]; other site 536019013636 metal binding site [ion binding]; metal-binding site 536019013637 substrate binding pocket [chemical binding]; other site 536019013638 PRC-barrel domain; Region: PRC; pfam05239 536019013639 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 536019013640 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536019013641 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 536019013642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019013643 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019013644 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019013645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019013646 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019013647 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019013648 active site 536019013649 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 536019013650 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 536019013651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019013652 S-adenosylmethionine binding site [chemical binding]; other site 536019013653 NmrA-like family; Region: NmrA; pfam05368 536019013654 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 536019013655 NADP binding site [chemical binding]; other site 536019013656 active site 536019013657 regulatory binding site [polypeptide binding]; other site 536019013658 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 536019013659 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 536019013660 putative active site [active] 536019013661 catalytic site [active] 536019013662 putative metal binding site [ion binding]; other site 536019013663 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 536019013664 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 536019013665 active site 536019013666 metal binding site [ion binding]; metal-binding site 536019013667 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 536019013668 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 536019013669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019013670 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 536019013671 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 536019013672 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019013673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019013674 putative DNA binding site [nucleotide binding]; other site 536019013675 putative Zn2+ binding site [ion binding]; other site 536019013676 AsnC family; Region: AsnC_trans_reg; pfam01037 536019013677 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 536019013678 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 536019013679 hexamer interface [polypeptide binding]; other site 536019013680 ligand binding site [chemical binding]; other site 536019013681 putative active site [active] 536019013682 NAD(P) binding site [chemical binding]; other site 536019013683 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 536019013684 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019013685 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 536019013686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019013687 Coenzyme A binding pocket [chemical binding]; other site 536019013688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019013689 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 536019013690 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 536019013691 active site residue [active] 536019013692 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 536019013693 active site residue [active] 536019013694 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 536019013695 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 536019013696 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536019013697 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536019013698 dimer interface [polypeptide binding]; other site 536019013699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019013700 catalytic residue [active] 536019013701 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 536019013702 short chain dehydrogenase; Provisional; Region: PRK07024 536019013703 putative NAD(P) binding site [chemical binding]; other site 536019013704 active site 536019013705 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019013706 helicase 45; Provisional; Region: PTZ00424 536019013707 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536019013708 ATP binding site [chemical binding]; other site 536019013709 Mg++ binding site [ion binding]; other site 536019013710 motif III; other site 536019013711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019013712 nucleotide binding region [chemical binding]; other site 536019013713 ATP-binding site [chemical binding]; other site 536019013714 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 536019013715 Predicted transcriptional regulator [Transcription]; Region: COG3905 536019013716 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 536019013717 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 536019013718 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 536019013719 Uncharacterized conserved protein [Function unknown]; Region: COG0062 536019013720 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 536019013721 putative substrate binding site [chemical binding]; other site 536019013722 putative ATP binding site [chemical binding]; other site 536019013723 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 536019013724 Nitrogen regulatory protein P-II; Region: P-II; smart00938 536019013725 glutamine synthetase; Provisional; Region: glnA; PRK09469 536019013726 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 536019013727 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019013728 glutamine synthetase; Region: PLN02284 536019013729 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 536019013730 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019013731 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 536019013732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019013733 putative substrate translocation pore; other site 536019013734 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 536019013735 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019013736 EamA-like transporter family; Region: EamA; pfam00892 536019013737 EamA-like transporter family; Region: EamA; pfam00892 536019013738 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 536019013739 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019013740 RNA binding surface [nucleotide binding]; other site 536019013741 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 536019013742 active site 536019013743 camphor resistance protein CrcB; Provisional; Region: PRK14195 536019013744 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 536019013745 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 536019013746 recombination factor protein RarA; Reviewed; Region: PRK13342 536019013747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019013748 Walker A motif; other site 536019013749 ATP binding site [chemical binding]; other site 536019013750 Walker B motif; other site 536019013751 arginine finger; other site 536019013752 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 536019013753 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 536019013754 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019013755 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019013756 protein binding site [polypeptide binding]; other site 536019013757 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019013758 protein binding site [polypeptide binding]; other site 536019013759 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 536019013760 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 536019013761 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 536019013762 alphaNTD homodimer interface [polypeptide binding]; other site 536019013763 alphaNTD - beta interaction site [polypeptide binding]; other site 536019013764 alphaNTD - beta' interaction site [polypeptide binding]; other site 536019013765 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 536019013766 30S ribosomal protein S11; Validated; Region: PRK05309 536019013767 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 536019013768 30S ribosomal protein S13; Region: bact_S13; TIGR03631 536019013769 adenylate kinase; Reviewed; Region: adk; PRK00279 536019013770 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 536019013771 AMP-binding site [chemical binding]; other site 536019013772 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 536019013773 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 536019013774 SecY translocase; Region: SecY; pfam00344 536019013775 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 536019013776 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 536019013777 23S rRNA binding site [nucleotide binding]; other site 536019013778 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 536019013779 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 536019013780 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 536019013781 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 536019013782 5S rRNA interface [nucleotide binding]; other site 536019013783 23S rRNA interface [nucleotide binding]; other site 536019013784 L5 interface [polypeptide binding]; other site 536019013785 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 536019013786 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 536019013787 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 536019013788 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 536019013789 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 536019013790 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 536019013791 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 536019013792 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 536019013793 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 536019013794 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 536019013795 RNA binding site [nucleotide binding]; other site 536019013796 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 536019013797 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 536019013798 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 536019013799 putative translocon interaction site; other site 536019013800 23S rRNA interface [nucleotide binding]; other site 536019013801 signal recognition particle (SRP54) interaction site; other site 536019013802 L23 interface [polypeptide binding]; other site 536019013803 trigger factor interaction site; other site 536019013804 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 536019013805 23S rRNA interface [nucleotide binding]; other site 536019013806 5S rRNA interface [nucleotide binding]; other site 536019013807 putative antibiotic binding site [chemical binding]; other site 536019013808 L25 interface [polypeptide binding]; other site 536019013809 L27 interface [polypeptide binding]; other site 536019013810 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 536019013811 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 536019013812 G-X-X-G motif; other site 536019013813 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 536019013814 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 536019013815 putative translocon binding site; other site 536019013816 protein-rRNA interface [nucleotide binding]; other site 536019013817 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 536019013818 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 536019013819 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 536019013820 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 536019013821 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 536019013822 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 536019013823 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 536019013824 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 536019013825 elongation factor Tu; Reviewed; Region: PRK00049 536019013826 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 536019013827 G1 box; other site 536019013828 GEF interaction site [polypeptide binding]; other site 536019013829 GTP/Mg2+ binding site [chemical binding]; other site 536019013830 Switch I region; other site 536019013831 G2 box; other site 536019013832 G3 box; other site 536019013833 Switch II region; other site 536019013834 G4 box; other site 536019013835 G5 box; other site 536019013836 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 536019013837 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 536019013838 Antibiotic Binding Site [chemical binding]; other site 536019013839 elongation factor G; Reviewed; Region: PRK00007 536019013840 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 536019013841 G1 box; other site 536019013842 putative GEF interaction site [polypeptide binding]; other site 536019013843 GTP/Mg2+ binding site [chemical binding]; other site 536019013844 Switch I region; other site 536019013845 G2 box; other site 536019013846 G3 box; other site 536019013847 Switch II region; other site 536019013848 G4 box; other site 536019013849 G5 box; other site 536019013850 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 536019013851 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 536019013852 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 536019013853 30S ribosomal protein S7; Validated; Region: PRK05302 536019013854 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 536019013855 S17 interaction site [polypeptide binding]; other site 536019013856 S8 interaction site; other site 536019013857 16S rRNA interaction site [nucleotide binding]; other site 536019013858 streptomycin interaction site [chemical binding]; other site 536019013859 23S rRNA interaction site [nucleotide binding]; other site 536019013860 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 536019013861 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019013862 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019013863 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 536019013864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019013865 S-adenosylmethionine binding site [chemical binding]; other site 536019013866 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 536019013867 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 536019013868 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 536019013869 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 536019013870 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 536019013871 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 536019013872 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 536019013873 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 536019013874 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 536019013875 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 536019013876 DNA binding site [nucleotide binding] 536019013877 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 536019013878 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 536019013879 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 536019013880 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 536019013881 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 536019013882 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 536019013883 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 536019013884 RPB1 interaction site [polypeptide binding]; other site 536019013885 RPB11 interaction site [polypeptide binding]; other site 536019013886 RPB10 interaction site [polypeptide binding]; other site 536019013887 RPB3 interaction site [polypeptide binding]; other site 536019013888 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 536019013889 L11 interface [polypeptide binding]; other site 536019013890 putative EF-Tu interaction site [polypeptide binding]; other site 536019013891 putative EF-G interaction site [polypeptide binding]; other site 536019013892 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 536019013893 23S rRNA interface [nucleotide binding]; other site 536019013894 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 536019013895 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 536019013896 mRNA/rRNA interface [nucleotide binding]; other site 536019013897 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 536019013898 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 536019013899 23S rRNA interface [nucleotide binding]; other site 536019013900 L7/L12 interface [polypeptide binding]; other site 536019013901 putative thiostrepton binding site; other site 536019013902 L25 interface [polypeptide binding]; other site 536019013903 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 536019013904 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 536019013905 putative homodimer interface [polypeptide binding]; other site 536019013906 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 536019013907 heterodimer interface [polypeptide binding]; other site 536019013908 homodimer interface [polypeptide binding]; other site 536019013909 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 536019013910 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536019013911 putative active site pocket [active] 536019013912 dimerization interface [polypeptide binding]; other site 536019013913 putative catalytic residue [active] 536019013914 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 536019013915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 536019013916 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 536019013917 apolar tunnel; other site 536019013918 heme binding site [chemical binding]; other site 536019013919 dimerization interface [polypeptide binding]; other site 536019013920 Predicted periplasmic protein [Function unknown]; Region: COG3904 536019013921 Predicted periplasmic protein [Function unknown]; Region: COG3904 536019013922 elongation factor Tu; Reviewed; Region: PRK00049 536019013923 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 536019013924 G1 box; other site 536019013925 GEF interaction site [polypeptide binding]; other site 536019013926 GTP/Mg2+ binding site [chemical binding]; other site 536019013927 Switch I region; other site 536019013928 G2 box; other site 536019013929 G3 box; other site 536019013930 Switch II region; other site 536019013931 G4 box; other site 536019013932 G5 box; other site 536019013933 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 536019013934 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 536019013935 Antibiotic Binding Site [chemical binding]; other site 536019013936 Predicted membrane protein [Function unknown]; Region: COG2261 536019013937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 536019013938 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 536019013939 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 536019013940 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536019013941 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019013942 tartronate semialdehyde reductase; Provisional; Region: PRK15059 536019013943 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 536019013944 glyoxylate carboligase; Provisional; Region: PRK11269 536019013945 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019013946 PYR/PP interface [polypeptide binding]; other site 536019013947 dimer interface [polypeptide binding]; other site 536019013948 TPP binding site [chemical binding]; other site 536019013949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019013950 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 536019013951 TPP-binding site [chemical binding]; other site 536019013952 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536019013953 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536019013954 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019013955 BA14K-like protein; Region: BA14K; pfam07886 536019013956 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 536019013957 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 536019013958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019013959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019013960 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019013961 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019013962 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019013963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013964 dimer interface [polypeptide binding]; other site 536019013965 conserved gate region; other site 536019013966 putative PBP binding loops; other site 536019013967 ABC-ATPase subunit interface; other site 536019013968 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019013969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019013970 dimer interface [polypeptide binding]; other site 536019013971 conserved gate region; other site 536019013972 putative PBP binding loops; other site 536019013973 ABC-ATPase subunit interface; other site 536019013974 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019013975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019013976 Walker A/P-loop; other site 536019013977 ATP binding site [chemical binding]; other site 536019013978 Q-loop/lid; other site 536019013979 ABC transporter signature motif; other site 536019013980 Walker B; other site 536019013981 D-loop; other site 536019013982 H-loop/switch region; other site 536019013983 TOBE domain; Region: TOBE_2; pfam08402 536019013984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019013985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019013986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019013987 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019013988 Amidase; Region: Amidase; cl11426 536019013989 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019013990 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019013991 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 536019013992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019013993 UDP-galactopyranose mutase; Region: GLF; pfam03275 536019013994 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 536019013995 helicase 45; Provisional; Region: PTZ00424 536019013996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536019013997 ATP binding site [chemical binding]; other site 536019013998 Mg++ binding site [ion binding]; other site 536019013999 motif III; other site 536019014000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019014001 nucleotide binding region [chemical binding]; other site 536019014002 ATP-binding site [chemical binding]; other site 536019014003 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 536019014004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536019014005 ligand binding site [chemical binding]; other site 536019014006 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019014007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019014008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019014009 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019014010 putative effector binding pocket; other site 536019014011 dimerization interface [polypeptide binding]; other site 536019014012 NmrA-like family; Region: NmrA; pfam05368 536019014013 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 536019014014 NADP binding site [chemical binding]; other site 536019014015 active site 536019014016 regulatory binding site [polypeptide binding]; other site 536019014017 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019014018 peptide chain release factor 2; Provisional; Region: PRK07342 536019014019 This domain is found in peptide chain release factors; Region: PCRF; smart00937 536019014020 RF-1 domain; Region: RF-1; pfam00472 536019014021 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 536019014022 Transglycosylase; Region: Transgly; pfam00912 536019014023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 536019014024 AMIN domain; Region: AMIN; pfam11741 536019014025 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 536019014026 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 536019014027 active site 536019014028 metal binding site [ion binding]; metal-binding site 536019014029 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 536019014030 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536019014031 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 536019014032 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 536019014033 glutaminase; Provisional; Region: PRK00971 536019014034 aspartate aminotransferase; Provisional; Region: PRK05764 536019014035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019014036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014037 homodimer interface [polypeptide binding]; other site 536019014038 catalytic residue [active] 536019014039 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 536019014040 Peptidase family M48; Region: Peptidase_M48; cl12018 536019014041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019014042 TPR motif; other site 536019014043 binding surface 536019014044 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 536019014045 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 536019014046 catalytic residues [active] 536019014047 Dehydroquinase class II; Region: DHquinase_II; pfam01220 536019014048 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 536019014049 trimer interface [polypeptide binding]; other site 536019014050 active site 536019014051 dimer interface [polypeptide binding]; other site 536019014052 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 536019014053 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536019014054 carboxyltransferase (CT) interaction site; other site 536019014055 biotinylation site [posttranslational modification]; other site 536019014056 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 536019014057 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019014058 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 536019014059 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536019014060 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 536019014061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 536019014062 NADH dehydrogenase; Validated; Region: PRK08183 536019014063 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 536019014064 oligomerization interface [polypeptide binding]; other site 536019014065 active site 536019014066 metal binding site [ion binding]; metal-binding site 536019014067 pantoate--beta-alanine ligase; Region: panC; TIGR00018 536019014068 Pantoate-beta-alanine ligase; Region: PanC; cd00560 536019014069 active site 536019014070 ATP-binding site [chemical binding]; other site 536019014071 pantoate-binding site; other site 536019014072 HXXH motif; other site 536019014073 Uncharacterized conserved protein [Function unknown]; Region: COG2013 536019014074 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019014075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019014076 Coenzyme A binding pocket [chemical binding]; other site 536019014077 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 536019014078 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 536019014079 GatB domain; Region: GatB_Yqey; smart00845 536019014080 hypothetical protein; Provisional; Region: PRK13687 536019014081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 536019014082 FOG: CBS domain [General function prediction only]; Region: COG0517 536019014083 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 536019014084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 536019014085 PAS domain; Region: PAS_5; pfam07310 536019014086 PilZ domain; Region: PilZ; pfam07238 536019014087 PilZ domain; Region: PilZ; pfam07238 536019014088 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 536019014089 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 536019014090 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 536019014091 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 536019014092 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 536019014093 trimer interface [polypeptide binding]; other site 536019014094 putative metal binding site [ion binding]; other site 536019014095 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 536019014096 serine acetyltransferase; Provisional; Region: cysE; PRK11132 536019014097 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 536019014098 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 536019014099 trimer interface [polypeptide binding]; other site 536019014100 active site 536019014101 substrate binding site [chemical binding]; other site 536019014102 CoA binding site [chemical binding]; other site 536019014103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 536019014104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019014105 Uncharacterized conserved protein [Function unknown]; Region: COG1430 536019014106 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019014107 DNA-binding site [nucleotide binding]; DNA binding site 536019014108 RNA-binding motif; other site 536019014109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019014110 DNA-binding site [nucleotide binding]; DNA binding site 536019014111 RNA-binding motif; other site 536019014112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019014113 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 536019014114 dimer interface [polypeptide binding]; other site 536019014115 active site 536019014116 metal binding site [ion binding]; metal-binding site 536019014117 glutathione binding site [chemical binding]; other site 536019014118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 536019014119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 536019014120 threonine dehydratase; Validated; Region: PRK08639 536019014121 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536019014122 tetramer interface [polypeptide binding]; other site 536019014123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014124 catalytic residue [active] 536019014125 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 536019014126 putative Ile/Val binding site [chemical binding]; other site 536019014127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 536019014128 Bor protein; Region: Lambda_Bor; pfam06291 536019014129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 536019014130 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 536019014131 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019014132 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 536019014133 active site 536019014134 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 536019014135 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019014136 Divergent AAA domain; Region: AAA_4; pfam04326 536019014137 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 536019014138 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 536019014139 dimer interface [polypeptide binding]; other site 536019014140 ADP-ribose binding site [chemical binding]; other site 536019014141 active site 536019014142 nudix motif; other site 536019014143 metal binding site [ion binding]; metal-binding site 536019014144 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 536019014145 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 536019014146 active site 536019014147 FMN binding site [chemical binding]; other site 536019014148 substrate binding site [chemical binding]; other site 536019014149 homotetramer interface [polypeptide binding]; other site 536019014150 catalytic residue [active] 536019014151 Bacterial SH3 domain; Region: SH3_3; pfam08239 536019014152 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019014153 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 536019014154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019014155 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 536019014156 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 536019014157 putative MPT binding site; other site 536019014158 Universal stress protein family; Region: Usp; pfam00582 536019014159 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019014160 Ligand Binding Site [chemical binding]; other site 536019014161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019014162 active site 536019014163 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 536019014164 nudix motif; other site 536019014165 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 536019014166 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 536019014167 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 536019014168 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 536019014169 active site 536019014170 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 536019014171 TSCPD domain; Region: TSCPD; pfam12637 536019014172 TfoX C-terminal domain; Region: TfoX_C; pfam04994 536019014173 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 536019014174 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 536019014175 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 536019014176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019014177 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019014178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019014179 S-adenosylmethionine binding site [chemical binding]; other site 536019014180 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 536019014181 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 536019014182 active site 536019014183 Predicted periplasmic protein [Function unknown]; Region: COG3698 536019014184 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 536019014185 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 536019014186 Bacitracin resistance protein BacA; Region: BacA; pfam02673 536019014187 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019014188 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 536019014189 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 536019014190 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 536019014191 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019014192 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 536019014193 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 536019014194 putative hydrophobic ligand binding site [chemical binding]; other site 536019014195 ParB-like nuclease domain; Region: ParB; smart00470 536019014196 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536019014197 active site 536019014198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019014199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019014200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536019014201 dimerization interface [polypeptide binding]; other site 536019014202 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019014203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019014204 substrate binding pocket [chemical binding]; other site 536019014205 membrane-bound complex binding site; other site 536019014206 hinge residues; other site 536019014207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014208 dimer interface [polypeptide binding]; other site 536019014209 conserved gate region; other site 536019014210 putative PBP binding loops; other site 536019014211 ABC-ATPase subunit interface; other site 536019014212 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019014213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014214 dimer interface [polypeptide binding]; other site 536019014215 conserved gate region; other site 536019014216 putative PBP binding loops; other site 536019014217 ABC-ATPase subunit interface; other site 536019014218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019014219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019014220 Walker A/P-loop; other site 536019014221 ATP binding site [chemical binding]; other site 536019014222 Q-loop/lid; other site 536019014223 ABC transporter signature motif; other site 536019014224 Walker B; other site 536019014225 D-loop; other site 536019014226 H-loop/switch region; other site 536019014227 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 536019014228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019014229 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 536019014230 inhibitor-cofactor binding pocket; inhibition site 536019014231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014232 catalytic residue [active] 536019014233 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 536019014234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019014235 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019014236 Coenzyme A binding pocket [chemical binding]; other site 536019014237 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 536019014238 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 536019014239 active site 536019014240 Zn binding site [ion binding]; other site 536019014241 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 536019014242 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 536019014243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019014244 catalytic residue [active] 536019014245 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019014246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019014247 active site 536019014248 catalytic tetrad [active] 536019014249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 536019014250 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 536019014251 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 536019014252 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 536019014253 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 536019014254 putative MPT binding site; other site 536019014255 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 536019014256 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 536019014257 Ligand binding site; other site 536019014258 metal-binding site 536019014259 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 536019014260 XdhC Rossmann domain; Region: XdhC_C; pfam13478 536019014261 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 536019014262 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 536019014263 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 536019014264 metal ion-dependent adhesion site (MIDAS); other site 536019014265 MoxR-like ATPases [General function prediction only]; Region: COG0714 536019014266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019014267 Walker A motif; other site 536019014268 ATP binding site [chemical binding]; other site 536019014269 Walker B motif; other site 536019014270 arginine finger; other site 536019014271 Flavin Reductases; Region: FlaRed; cl00801 536019014272 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019014273 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019014274 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 536019014275 putative active site pocket [active] 536019014276 cleavage site 536019014277 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 536019014278 cleavage site 536019014279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3798 536019014280 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 536019014281 adenylosuccinate lyase; Provisional; Region: PRK07492 536019014282 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 536019014283 tetramer interface [polypeptide binding]; other site 536019014284 active site 536019014285 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 536019014286 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 536019014287 putative metal binding site [ion binding]; other site 536019014288 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 536019014289 active site 536019014290 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 536019014291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019014292 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 536019014293 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 536019014294 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 536019014295 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 536019014296 ATP binding site [chemical binding]; other site 536019014297 active site 536019014298 substrate binding site [chemical binding]; other site 536019014299 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 536019014300 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 536019014301 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 536019014302 putative active site [active] 536019014303 catalytic triad [active] 536019014304 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019014305 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536019014306 C-terminal domain interface [polypeptide binding]; other site 536019014307 GSH binding site (G-site) [chemical binding]; other site 536019014308 dimer interface [polypeptide binding]; other site 536019014309 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 536019014310 N-terminal domain interface [polypeptide binding]; other site 536019014311 dimer interface [polypeptide binding]; other site 536019014312 substrate binding pocket (H-site) [chemical binding]; other site 536019014313 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536019014314 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536019014315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019014316 DNA-binding site [nucleotide binding]; DNA binding site 536019014317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019014318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014319 homodimer interface [polypeptide binding]; other site 536019014320 catalytic residue [active] 536019014321 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 536019014322 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 536019014323 dimerization interface [polypeptide binding]; other site 536019014324 ATP binding site [chemical binding]; other site 536019014325 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 536019014326 dimerization interface [polypeptide binding]; other site 536019014327 ATP binding site [chemical binding]; other site 536019014328 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 536019014329 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 536019014330 putative GSH binding site [chemical binding]; other site 536019014331 catalytic residues [active] 536019014332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014333 putative substrate translocation pore; other site 536019014334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 536019014335 putative dimer interface [polypeptide binding]; other site 536019014336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019014337 Gram-negative bacterial tonB protein; Region: TonB; cl10048 536019014338 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019014339 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 536019014340 active site 536019014341 putative lithium-binding site [ion binding]; other site 536019014342 substrate binding site [chemical binding]; other site 536019014343 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 536019014344 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 536019014345 Ligand Binding Site [chemical binding]; other site 536019014346 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 536019014347 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 536019014348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019014349 RNA binding surface [nucleotide binding]; other site 536019014350 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 536019014351 RNB domain; Region: RNB; pfam00773 536019014352 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 536019014353 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536019014354 RNA binding site [nucleotide binding]; other site 536019014355 glutamate racemase; Provisional; Region: PRK00865 536019014356 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 536019014357 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 536019014358 isocitrate dehydrogenase; Validated; Region: PRK08299 536019014359 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 536019014360 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019014361 C-terminal domain interface [polypeptide binding]; other site 536019014362 GSH binding site (G-site) [chemical binding]; other site 536019014363 dimer interface [polypeptide binding]; other site 536019014364 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 536019014365 dimer interface [polypeptide binding]; other site 536019014366 N-terminal domain interface [polypeptide binding]; other site 536019014367 substrate binding pocket (H-site) [chemical binding]; other site 536019014368 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 536019014369 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 536019014370 motif 1; other site 536019014371 active site 536019014372 motif 2; other site 536019014373 motif 3; other site 536019014374 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 536019014375 DHHA1 domain; Region: DHHA1; pfam02272 536019014376 recombinase A; Provisional; Region: recA; PRK09354 536019014377 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 536019014378 hexamer interface [polypeptide binding]; other site 536019014379 Walker A motif; other site 536019014380 ATP binding site [chemical binding]; other site 536019014381 Walker B motif; other site 536019014382 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019014383 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 536019014384 substrate binding site [chemical binding]; other site 536019014385 ATP binding site [chemical binding]; other site 536019014386 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 536019014387 TfoX N-terminal domain; Region: TfoX_N; pfam04993 536019014388 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019014389 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 536019014390 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 536019014391 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 536019014392 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 536019014393 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019014394 catalytic residue [active] 536019014395 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 536019014396 FeS assembly protein SufD; Region: sufD; TIGR01981 536019014397 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 536019014398 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 536019014399 Walker A/P-loop; other site 536019014400 ATP binding site [chemical binding]; other site 536019014401 Q-loop/lid; other site 536019014402 ABC transporter signature motif; other site 536019014403 Walker B; other site 536019014404 D-loop; other site 536019014405 H-loop/switch region; other site 536019014406 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 536019014407 putative ABC transporter; Region: ycf24; CHL00085 536019014408 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 536019014409 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 536019014410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019014411 catalytic residue [active] 536019014412 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 536019014413 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 536019014414 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 536019014415 active site 536019014416 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 536019014417 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 536019014418 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 536019014419 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019014420 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 536019014421 Ligand binding site; other site 536019014422 Putative Catalytic site; other site 536019014423 DXD motif; other site 536019014424 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 536019014425 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 536019014426 active site 536019014427 HIGH motif; other site 536019014428 dimer interface [polypeptide binding]; other site 536019014429 KMSKS motif; other site 536019014430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019014431 RNA binding surface [nucleotide binding]; other site 536019014432 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 536019014433 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 536019014434 catalytic triad [active] 536019014435 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019014436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019014437 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 536019014438 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 536019014439 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 536019014440 Peptidase family M23; Region: Peptidase_M23; pfam01551 536019014441 Methyltransferase domain; Region: Methyltransf_24; pfam13578 536019014442 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 536019014443 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019014444 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019014445 active site 536019014446 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019014447 non-specific DNA interactions [nucleotide binding]; other site 536019014448 DNA binding site [nucleotide binding] 536019014449 sequence specific DNA binding site [nucleotide binding]; other site 536019014450 putative cAMP binding site [chemical binding]; other site 536019014451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019014452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019014453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019014454 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 536019014455 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019014456 Walker A/P-loop; other site 536019014457 ATP binding site [chemical binding]; other site 536019014458 Q-loop/lid; other site 536019014459 ABC transporter signature motif; other site 536019014460 Walker B; other site 536019014461 D-loop; other site 536019014462 H-loop/switch region; other site 536019014463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019014464 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019014465 ligand binding site [chemical binding]; other site 536019014466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019014467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019014468 TM-ABC transporter signature motif; other site 536019014469 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 536019014470 classical (c) SDRs; Region: SDR_c; cd05233 536019014471 NAD(P) binding site [chemical binding]; other site 536019014472 active site 536019014473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019014474 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 536019014475 substrate binding site [chemical binding]; other site 536019014476 dimer interface [polypeptide binding]; other site 536019014477 ATP binding site [chemical binding]; other site 536019014478 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 536019014479 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019014480 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019014481 Walker A/P-loop; other site 536019014482 ATP binding site [chemical binding]; other site 536019014483 Q-loop/lid; other site 536019014484 ABC transporter signature motif; other site 536019014485 Walker B; other site 536019014486 D-loop; other site 536019014487 H-loop/switch region; other site 536019014488 TOBE domain; Region: TOBE_2; pfam08402 536019014489 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019014490 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 536019014491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014492 dimer interface [polypeptide binding]; other site 536019014493 conserved gate region; other site 536019014494 putative PBP binding loops; other site 536019014495 ABC-ATPase subunit interface; other site 536019014496 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019014497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014498 dimer interface [polypeptide binding]; other site 536019014499 conserved gate region; other site 536019014500 putative PBP binding loops; other site 536019014501 ABC-ATPase subunit interface; other site 536019014502 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 536019014503 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019014504 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 536019014505 tetramer interface [polypeptide binding]; other site 536019014506 active site 536019014507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019014508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019014509 active site 536019014510 catalytic tetrad [active] 536019014511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536019014512 IHF dimer interface [polypeptide binding]; other site 536019014513 IHF - DNA interface [nucleotide binding]; other site 536019014514 Found in ATP-dependent protease La (LON); Region: LON; smart00464 536019014515 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 536019014516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019014517 Walker A motif; other site 536019014518 ATP binding site [chemical binding]; other site 536019014519 Walker B motif; other site 536019014520 arginine finger; other site 536019014521 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 536019014522 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 536019014523 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 536019014524 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 536019014525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019014526 Walker A motif; other site 536019014527 ATP binding site [chemical binding]; other site 536019014528 Walker B motif; other site 536019014529 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 536019014530 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 536019014531 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 536019014532 oligomer interface [polypeptide binding]; other site 536019014533 active site residues [active] 536019014534 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 536019014535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019014536 catalytic residue [active] 536019014537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019014538 Cytochrome P450; Region: p450; cl12078 536019014539 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 536019014540 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 536019014541 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536019014542 homodimer interface [polypeptide binding]; other site 536019014543 substrate-cofactor binding pocket; other site 536019014544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014545 catalytic residue [active] 536019014546 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 536019014547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019014548 Predicted ATPase [General function prediction only]; Region: COG3910 536019014549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019014550 Walker A/P-loop; other site 536019014551 Walker A/P-loop; other site 536019014552 ATP binding site [chemical binding]; other site 536019014553 ATP binding site [chemical binding]; other site 536019014554 Q-loop/lid; other site 536019014555 ABC transporter signature motif; other site 536019014556 Walker B; other site 536019014557 D-loop; other site 536019014558 H-loop/switch region; other site 536019014559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019014560 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 536019014561 enoyl-CoA hydratase; Validated; Region: PRK08139 536019014562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019014563 substrate binding site [chemical binding]; other site 536019014564 oxyanion hole (OAH) forming residues; other site 536019014565 trimer interface [polypeptide binding]; other site 536019014566 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536019014567 CoenzymeA binding site [chemical binding]; other site 536019014568 subunit interaction site [polypeptide binding]; other site 536019014569 PHB binding site; other site 536019014570 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019014571 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 536019014572 23S rRNA interface [nucleotide binding]; other site 536019014573 L3 interface [polypeptide binding]; other site 536019014574 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 536019014575 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 536019014576 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 536019014577 putative active site [active] 536019014578 catalytic site [active] 536019014579 putative metal binding site [ion binding]; other site 536019014580 oligomer interface [polypeptide binding]; other site 536019014581 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019014582 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 536019014583 agmatinase; Region: agmatinase; TIGR01230 536019014584 oligomer interface [polypeptide binding]; other site 536019014585 putative active site [active] 536019014586 Mn binding site [ion binding]; other site 536019014587 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 536019014588 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536019014589 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 536019014590 Phosphotransferase enzyme family; Region: APH; pfam01636 536019014591 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 536019014592 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 536019014593 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 536019014594 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 536019014595 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 536019014596 putative active site [active] 536019014597 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019014598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019014599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 536019014600 Coenzyme A binding pocket [chemical binding]; other site 536019014601 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 536019014602 Chain length determinant protein; Region: Wzz; cl15801 536019014603 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536019014604 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 536019014605 SLBB domain; Region: SLBB; pfam10531 536019014606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019014607 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019014608 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 536019014609 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 536019014610 O-Antigen ligase; Region: Wzy_C; pfam04932 536019014611 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019014612 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 536019014613 putative deacylase active site [active] 536019014614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019014615 non-specific DNA binding site [nucleotide binding]; other site 536019014616 salt bridge; other site 536019014617 sequence-specific DNA binding site [nucleotide binding]; other site 536019014618 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 536019014619 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 536019014620 DNA binding residues [nucleotide binding] 536019014621 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536019014622 IHF dimer interface [polypeptide binding]; other site 536019014623 IHF - DNA interface [nucleotide binding]; other site 536019014624 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 536019014625 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 536019014626 dimer interface [polypeptide binding]; other site 536019014627 active site 536019014628 CoA binding pocket [chemical binding]; other site 536019014629 putative phosphate acyltransferase; Provisional; Region: PRK05331 536019014630 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 536019014631 Uncharacterized conserved protein [Function unknown]; Region: COG5452 536019014632 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 536019014633 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 536019014634 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 536019014635 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 536019014636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536019014637 active site 536019014638 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 536019014639 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 536019014640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014641 putative PBP binding loops; other site 536019014642 dimer interface [polypeptide binding]; other site 536019014643 ABC-ATPase subunit interface; other site 536019014644 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 536019014645 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 536019014646 Walker A/P-loop; other site 536019014647 ATP binding site [chemical binding]; other site 536019014648 Q-loop/lid; other site 536019014649 ABC transporter signature motif; other site 536019014650 Walker B; other site 536019014651 D-loop; other site 536019014652 H-loop/switch region; other site 536019014653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019014654 dimer interface [polypeptide binding]; other site 536019014655 conserved gate region; other site 536019014656 ABC-ATPase subunit interface; other site 536019014657 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 536019014658 Predicted flavoprotein [General function prediction only]; Region: COG0431 536019014659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019014660 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 536019014661 putative RNA binding site [nucleotide binding]; other site 536019014662 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 536019014663 homopentamer interface [polypeptide binding]; other site 536019014664 active site 536019014665 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 536019014666 Predicted transcriptional regulator [Transcription]; Region: COG3905 536019014667 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 536019014668 Lumazine binding domain; Region: Lum_binding; pfam00677 536019014669 Lumazine binding domain; Region: Lum_binding; pfam00677 536019014670 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 536019014671 catalytic motif [active] 536019014672 Zn binding site [ion binding]; other site 536019014673 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 536019014674 RibD C-terminal domain; Region: RibD_C; cl17279 536019014675 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 536019014676 ATP cone domain; Region: ATP-cone; pfam03477 536019014677 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 536019014678 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 536019014679 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 536019014680 dimer interface [polypeptide binding]; other site 536019014681 active site 536019014682 glycine-pyridoxal phosphate binding site [chemical binding]; other site 536019014683 folate binding site [chemical binding]; other site 536019014684 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 536019014685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 536019014686 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019014687 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019014688 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019014689 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019014690 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 536019014691 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 536019014692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019014693 substrate binding site [chemical binding]; other site 536019014694 oxyanion hole (OAH) forming residues; other site 536019014695 trimer interface [polypeptide binding]; other site 536019014696 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 536019014697 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 536019014698 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 536019014699 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 536019014700 dimer interface [polypeptide binding]; other site 536019014701 allosteric magnesium binding site [ion binding]; other site 536019014702 active site 536019014703 aspartate-rich active site metal binding site; other site 536019014704 Schiff base residues; other site 536019014705 RibD C-terminal domain; Region: RibD_C; cl17279 536019014706 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019014707 Uncharacterized conserved protein [Function unknown]; Region: COG2326 536019014708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019014709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019014710 active site 536019014711 catalytic tetrad [active] 536019014712 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 536019014713 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 536019014714 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019014715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019014716 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019014717 DNA-binding site [nucleotide binding]; DNA binding site 536019014718 FCD domain; Region: FCD; pfam07729 536019014719 drug efflux system protein MdtG; Provisional; Region: PRK09874 536019014720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014721 putative substrate translocation pore; other site 536019014722 Protein of unknown function (DUF423); Region: DUF423; cl01008 536019014723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019014724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 536019014725 DNA binding site [nucleotide binding] 536019014726 domain linker motif; other site 536019014727 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 536019014728 putative dimerization interface [polypeptide binding]; other site 536019014729 putative ligand binding site [chemical binding]; other site 536019014730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 536019014731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536019014732 Predicted esterase [General function prediction only]; Region: COG0400 536019014733 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 536019014734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019014735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536019014736 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536019014737 Predicted membrane protein/domain [Function unknown]; Region: COG1714 536019014738 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 536019014739 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 536019014740 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 536019014741 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019014742 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536019014743 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536019014744 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 536019014745 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 536019014746 CAP-like domain; other site 536019014747 active site 536019014748 primary dimer interface [polypeptide binding]; other site 536019014749 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536019014750 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 536019014751 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 536019014752 dimer interface [polypeptide binding]; other site 536019014753 anticodon binding site; other site 536019014754 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 536019014755 homodimer interface [polypeptide binding]; other site 536019014756 motif 1; other site 536019014757 active site 536019014758 motif 2; other site 536019014759 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019014760 active site 536019014761 motif 3; other site 536019014762 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019014763 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536019014764 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019014765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014767 putative substrate translocation pore; other site 536019014768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019014769 ribonuclease D; Region: rnd; TIGR01388 536019014770 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 536019014771 catalytic site [active] 536019014772 putative active site [active] 536019014773 putative substrate binding site [chemical binding]; other site 536019014774 MAPEG family; Region: MAPEG; cl09190 536019014775 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 536019014776 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536019014777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 536019014778 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 536019014779 active site 536019014780 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 536019014781 putative active site [active] 536019014782 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 536019014783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019014785 putative substrate translocation pore; other site 536019014786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019014787 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 536019014788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019014789 S-adenosylmethionine binding site [chemical binding]; other site 536019014790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019014791 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019014792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019014793 exopolyphosphatase; Region: exo_poly_only; TIGR03706 536019014794 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 536019014795 Predicted integral membrane protein [Function unknown]; Region: COG0392 536019014796 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 536019014797 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 536019014798 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 536019014799 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 536019014800 MoxR-like ATPases [General function prediction only]; Region: COG0714 536019014801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019014802 Walker A motif; other site 536019014803 ATP binding site [chemical binding]; other site 536019014804 Walker B motif; other site 536019014805 arginine finger; other site 536019014806 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 536019014807 Protein of unknown function DUF58; Region: DUF58; pfam01882 536019014808 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 536019014809 metal ion-dependent adhesion site (MIDAS); other site 536019014810 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 536019014811 Predicted membrane protein/domain [Function unknown]; Region: COG1714 536019014812 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 536019014813 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 536019014814 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 536019014815 dimer interface [polypeptide binding]; other site 536019014816 active site 536019014817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019014818 substrate binding site [chemical binding]; other site 536019014819 catalytic residue [active] 536019014820 heme exporter protein CcmC; Region: ccmC; TIGR01191 536019014821 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 536019014822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019014823 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 536019014824 Walker A/P-loop; other site 536019014825 ATP binding site [chemical binding]; other site 536019014826 Q-loop/lid; other site 536019014827 ABC transporter signature motif; other site 536019014828 Walker B; other site 536019014829 D-loop; other site 536019014830 H-loop/switch region; other site 536019014831 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 536019014832 Putative glucoamylase; Region: Glycoamylase; pfam10091 536019014833 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 536019014834 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 536019014835 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 536019014836 HutD; Region: HutD; pfam05962 536019014837 urocanate hydratase; Provisional; Region: PRK05414 536019014838 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 536019014839 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 536019014840 active sites [active] 536019014841 tetramer interface [polypeptide binding]; other site 536019014842 imidazolonepropionase; Validated; Region: PRK09356 536019014843 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 536019014844 active site 536019014845 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 536019014846 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 536019014847 active site 536019014848 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 536019014849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019014850 DNA-binding site [nucleotide binding]; DNA binding site 536019014851 UTRA domain; Region: UTRA; pfam07702 536019014852 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 536019014853 homotrimer interaction site [polypeptide binding]; other site 536019014854 putative active site [active] 536019014855 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 536019014856 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 536019014857 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 536019014858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536019014859 ABC-ATPase subunit interface; other site 536019014860 dimer interface [polypeptide binding]; other site 536019014861 putative PBP binding regions; other site 536019014862 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 536019014863 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 536019014864 metal binding site [ion binding]; metal-binding site 536019014865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 536019014866 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019014867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019014868 putative DNA binding site [nucleotide binding]; other site 536019014869 putative Zn2+ binding site [ion binding]; other site 536019014870 AsnC family; Region: AsnC_trans_reg; pfam01037 536019014871 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 536019014872 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 536019014873 dimer interface [polypeptide binding]; other site 536019014874 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 536019014875 active site 536019014876 Fe binding site [ion binding]; other site 536019014877 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 536019014878 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 536019014879 putative active site [active] 536019014880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 536019014881 DinB superfamily; Region: DinB_2; pfam12867 536019014882 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536019014883 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019014884 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 536019014885 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 536019014886 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 536019014887 MarR family; Region: MarR; pfam01047 536019014888 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 536019014889 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019014890 NAD(P) binding site [chemical binding]; other site 536019014891 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 536019014892 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 536019014893 substrate-cofactor binding pocket; other site 536019014894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019014895 catalytic residue [active] 536019014896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019014897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019014898 metal binding site [ion binding]; metal-binding site 536019014899 active site 536019014900 I-site; other site 536019014901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019014902 potential frameshift: common BLAST hit: gi|319784238|ref|YP_004143714.1| polysaccharide deacetylase 536019014903 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 536019014904 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 536019014905 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 536019014906 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 536019014907 oligomeric interface; other site 536019014908 putative active site [active] 536019014909 homodimer interface [polypeptide binding]; other site 536019014910 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 536019014911 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019014912 MarR family; Region: MarR; pfam01047 536019014913 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 536019014914 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 536019014915 putative active site [active] 536019014916 putative FMN binding site [chemical binding]; other site 536019014917 putative substrate binding site [chemical binding]; other site 536019014918 putative catalytic residue [active] 536019014919 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 536019014920 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 536019014921 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 536019014922 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019014923 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 536019014924 metal binding site [ion binding]; metal-binding site 536019014925 substrate binding pocket [chemical binding]; other site 536019014926 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 536019014927 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 536019014928 B12 binding site [chemical binding]; other site 536019014929 cobalt ligand [ion binding]; other site 536019014930 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019014931 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019014932 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 536019014933 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 536019014934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019014935 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019014936 dimerization interface [polypeptide binding]; other site 536019014937 substrate binding pocket [chemical binding]; other site 536019014938 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 536019014939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019014940 ATP binding site [chemical binding]; other site 536019014941 Mg2+ binding site [ion binding]; other site 536019014942 G-X-G motif; other site 536019014943 DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119 536019014944 ATP binding site [chemical binding]; other site 536019014945 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 536019014946 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536019014947 EamA-like transporter family; Region: EamA; pfam00892 536019014948 EamA-like transporter family; Region: EamA; pfam00892 536019014949 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 536019014950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019014951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019014952 dimerization interface [polypeptide binding]; other site 536019014953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 536019014954 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 536019014955 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 536019014956 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 536019014957 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 536019014958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 536019014959 putative acyl-acceptor binding pocket; other site 536019014960 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 536019014961 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019014962 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 536019014963 active site 536019014964 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 536019014965 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 536019014966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019014967 putative metal binding site [ion binding]; other site 536019014968 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 536019014969 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536019014970 motif 1; other site 536019014971 dimer interface [polypeptide binding]; other site 536019014972 active site 536019014973 motif 2; other site 536019014974 motif 3; other site 536019014975 elongation factor P; Validated; Region: PRK00529 536019014976 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 536019014977 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 536019014978 RNA binding site [nucleotide binding]; other site 536019014979 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 536019014980 RNA binding site [nucleotide binding]; other site 536019014981 EVE domain; Region: EVE; cl00728 536019014982 HNH endonuclease; Region: HNH_2; pfam13391 536019014983 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536019014984 RibD C-terminal domain; Region: RibD_C; cl17279 536019014985 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 536019014986 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 536019014987 nucleophile elbow; other site 536019014988 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536019014989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536019014990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536019014991 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 536019014992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536019014993 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 536019014994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019014995 S-adenosylmethionine binding site [chemical binding]; other site 536019014996 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 536019014997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019014998 RNA binding surface [nucleotide binding]; other site 536019014999 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 536019015000 active site 536019015001 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 536019015002 nucleoside/Zn binding site; other site 536019015003 dimer interface [polypeptide binding]; other site 536019015004 catalytic motif [active] 536019015005 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 536019015006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536019015007 active site 536019015008 HIGH motif; other site 536019015009 nucleotide binding site [chemical binding]; other site 536019015010 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 536019015011 active site 536019015012 KMSKS motif; other site 536019015013 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 536019015014 tRNA binding surface [nucleotide binding]; other site 536019015015 anticodon binding site; other site 536019015016 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 536019015017 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 536019015018 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 536019015019 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 536019015020 active site 536019015021 Riboflavin kinase; Region: Flavokinase; smart00904 536019015022 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 536019015023 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 536019015024 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 536019015025 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019015026 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 536019015027 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 536019015028 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019015029 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 536019015030 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019015031 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536019015032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019015033 Predicted integral membrane protein [Function unknown]; Region: COG5473 536019015034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015036 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 536019015037 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 536019015038 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 536019015039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019015040 dimerization interface [polypeptide binding]; other site 536019015041 putative DNA binding site [nucleotide binding]; other site 536019015042 putative Zn2+ binding site [ion binding]; other site 536019015043 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019015044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019015045 putative substrate translocation pore; other site 536019015046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019015047 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536019015048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019015049 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019015050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019015051 MarR family; Region: MarR_2; pfam12802 536019015052 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 536019015053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536019015054 ABC-ATPase subunit interface; other site 536019015055 dimer interface [polypeptide binding]; other site 536019015056 putative PBP binding regions; other site 536019015057 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 536019015058 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 536019015059 putative ligand binding residues [chemical binding]; other site 536019015060 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 536019015061 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536019015062 Walker A/P-loop; other site 536019015063 ATP binding site [chemical binding]; other site 536019015064 Q-loop/lid; other site 536019015065 ABC transporter signature motif; other site 536019015066 Walker B; other site 536019015067 D-loop; other site 536019015068 H-loop/switch region; other site 536019015069 Predicted metal-binding protein [Function unknown]; Region: COG5469 536019015070 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 536019015071 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 536019015072 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 536019015073 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019015074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019015075 DNA binding site [nucleotide binding] 536019015076 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019015077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015078 TPR motif; other site 536019015079 binding surface 536019015080 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 536019015081 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 536019015082 putative catalytic site [active] 536019015083 putative metal binding site [ion binding]; other site 536019015084 putative phosphate binding site [ion binding]; other site 536019015085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019015086 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 536019015087 putative ligand binding site [chemical binding]; other site 536019015088 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019015089 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019015090 TM-ABC transporter signature motif; other site 536019015091 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019015092 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019015093 Walker A/P-loop; other site 536019015094 ATP binding site [chemical binding]; other site 536019015095 Q-loop/lid; other site 536019015096 ABC transporter signature motif; other site 536019015097 Walker B; other site 536019015098 D-loop; other site 536019015099 H-loop/switch region; other site 536019015100 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019015101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019015102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019015103 DNA binding site [nucleotide binding] 536019015104 domain linker motif; other site 536019015105 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019015106 ligand binding site [chemical binding]; other site 536019015107 dimerization interface [polypeptide binding]; other site 536019015108 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 536019015109 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 536019015110 Probable Catalytic site; other site 536019015111 metal-binding site 536019015112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019015113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019015114 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 536019015115 Probable Catalytic site; other site 536019015116 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 536019015117 metal-binding site 536019015118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536019015119 active site 536019015120 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019015121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 536019015122 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019015123 MarR family; Region: MarR_2; pfam12802 536019015124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019015125 Coenzyme A binding pocket [chemical binding]; other site 536019015126 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 536019015127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 536019015128 dimer interface [polypeptide binding]; other site 536019015129 active site 536019015130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019015131 substrate binding site [chemical binding]; other site 536019015132 catalytic residue [active] 536019015133 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 536019015134 FAD binding domain; Region: FAD_binding_4; pfam01565 536019015135 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 536019015136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015138 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 536019015139 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 536019015140 oligomerisation interface [polypeptide binding]; other site 536019015141 mobile loop; other site 536019015142 roof hairpin; other site 536019015143 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 536019015144 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 536019015145 ring oligomerisation interface [polypeptide binding]; other site 536019015146 ATP/Mg binding site [chemical binding]; other site 536019015147 stacking interactions; other site 536019015148 hinge regions; other site 536019015149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015151 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 536019015152 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019015153 putative NAD(P) binding site [chemical binding]; other site 536019015154 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 536019015155 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019015156 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019015157 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 536019015158 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019015159 DNA-binding site [nucleotide binding]; DNA binding site 536019015160 RNA-binding motif; other site 536019015161 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 536019015162 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 536019015163 NADP binding site [chemical binding]; other site 536019015164 homotetramer interface [polypeptide binding]; other site 536019015165 homodimer interface [polypeptide binding]; other site 536019015166 active site 536019015167 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 536019015168 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019015169 putative C-terminal domain interface [polypeptide binding]; other site 536019015170 putative GSH binding site (G-site) [chemical binding]; other site 536019015171 putative dimer interface [polypeptide binding]; other site 536019015172 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 536019015173 putative N-terminal domain interface [polypeptide binding]; other site 536019015174 putative dimer interface [polypeptide binding]; other site 536019015175 putative substrate binding pocket (H-site) [chemical binding]; other site 536019015176 CsbD-like; Region: CsbD; pfam05532 536019015177 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 536019015178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015180 NIPSNAP; Region: NIPSNAP; pfam07978 536019015181 NIPSNAP; Region: NIPSNAP; pfam07978 536019015182 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019015183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019015184 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 536019015185 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 536019015186 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 536019015187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015188 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536019015189 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 536019015190 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 536019015191 classical (c) SDRs; Region: SDR_c; cd05233 536019015192 NAD(P) binding site [chemical binding]; other site 536019015193 active site 536019015194 Protein of unknown function (DUF805); Region: DUF805; pfam05656 536019015195 fumarate hydratase; Reviewed; Region: fumC; PRK00485 536019015196 Class II fumarases; Region: Fumarase_classII; cd01362 536019015197 active site 536019015198 tetramer interface [polypeptide binding]; other site 536019015199 Predicted membrane protein [Function unknown]; Region: COG2259 536019015200 Predicted membrane protein [Function unknown]; Region: COG2259 536019015201 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 536019015202 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 536019015203 polyphosphate kinase; Provisional; Region: PRK05443 536019015204 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 536019015205 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 536019015206 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 536019015207 putative domain interface [polypeptide binding]; other site 536019015208 putative active site [active] 536019015209 catalytic site [active] 536019015210 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 536019015211 putative domain interface [polypeptide binding]; other site 536019015212 putative active site [active] 536019015213 catalytic site [active] 536019015214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 536019015215 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019015216 salicylate hydroxylase; Provisional; Region: PRK08163 536019015217 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 536019015218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019015219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019015220 Walker A/P-loop; other site 536019015221 ATP binding site [chemical binding]; other site 536019015222 Q-loop/lid; other site 536019015223 ABC transporter signature motif; other site 536019015224 Walker B; other site 536019015225 D-loop; other site 536019015226 H-loop/switch region; other site 536019015227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019015228 dimer interface [polypeptide binding]; other site 536019015229 conserved gate region; other site 536019015230 putative PBP binding loops; other site 536019015231 ABC-ATPase subunit interface; other site 536019015232 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 536019015233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 536019015234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019015235 dimer interface [polypeptide binding]; other site 536019015236 conserved gate region; other site 536019015237 putative PBP binding loops; other site 536019015238 ABC-ATPase subunit interface; other site 536019015239 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 536019015240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019015241 substrate binding pocket [chemical binding]; other site 536019015242 membrane-bound complex binding site; other site 536019015243 hinge residues; other site 536019015244 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 536019015245 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 536019015246 Uncharacterized conserved protein [Function unknown]; Region: COG5588 536019015247 cystathionine beta-lyase; Provisional; Region: PRK05967 536019015248 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536019015249 homodimer interface [polypeptide binding]; other site 536019015250 substrate-cofactor binding pocket; other site 536019015251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019015252 catalytic residue [active] 536019015253 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 536019015254 HPP family; Region: HPP; pfam04982 536019015255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 536019015256 RNA polymerase sigma factor; Provisional; Region: PRK11922 536019015257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019015258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019015259 DNA binding residues [nucleotide binding] 536019015260 Predicted outer membrane protein [Function unknown]; Region: COG3652 536019015261 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 536019015262 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 536019015263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015264 binding surface 536019015265 TPR motif; other site 536019015266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015267 TPR repeat; Region: TPR_11; pfam13414 536019015268 binding surface 536019015269 TPR motif; other site 536019015270 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 536019015271 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 536019015272 transmembrane helices; other site 536019015273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019015274 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019015275 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019015276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019015277 metal binding site [ion binding]; metal-binding site 536019015278 active site 536019015279 I-site; other site 536019015280 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 536019015281 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 536019015282 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 536019015283 hypothetical protein; Validated; Region: PRK09087 536019015284 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536019015285 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536019015286 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 536019015287 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 536019015288 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 536019015289 dimerization interface [polypeptide binding]; other site 536019015290 putative ATP binding site [chemical binding]; other site 536019015291 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 536019015292 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 536019015293 active site 536019015294 substrate binding site [chemical binding]; other site 536019015295 cosubstrate binding site; other site 536019015296 catalytic site [active] 536019015297 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 536019015298 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 536019015299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019015300 catalytic core [active] 536019015301 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019015302 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019015303 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019015304 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 536019015305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019015306 active site 536019015307 phosphorylation site [posttranslational modification] 536019015308 intermolecular recognition site; other site 536019015309 dimerization interface [polypeptide binding]; other site 536019015310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019015311 DNA binding site [nucleotide binding] 536019015312 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 536019015313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019015314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019015315 dimer interface [polypeptide binding]; other site 536019015316 phosphorylation site [posttranslational modification] 536019015317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019015318 ATP binding site [chemical binding]; other site 536019015319 Mg2+ binding site [ion binding]; other site 536019015320 G-X-G motif; other site 536019015321 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019015322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019015323 ABC-ATPase subunit interface; other site 536019015324 putative PBP binding loops; other site 536019015325 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019015326 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019015327 Walker A/P-loop; other site 536019015328 ATP binding site [chemical binding]; other site 536019015329 Q-loop/lid; other site 536019015330 ABC transporter signature motif; other site 536019015331 Walker B; other site 536019015332 D-loop; other site 536019015333 H-loop/switch region; other site 536019015334 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 536019015335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 536019015336 dihydrodipicolinate reductase; Provisional; Region: PRK00048 536019015337 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 536019015338 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 536019015339 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 536019015340 Part of AAA domain; Region: AAA_19; pfam13245 536019015341 Family description; Region: UvrD_C_2; pfam13538 536019015342 allantoate amidohydrolase; Reviewed; Region: PRK12890 536019015343 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 536019015344 active site 536019015345 metal binding site [ion binding]; metal-binding site 536019015346 dimer interface [polypeptide binding]; other site 536019015347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 536019015348 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 536019015349 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 536019015350 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 536019015351 catalytic residue [active] 536019015352 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 536019015353 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019015354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019015355 putative DNA binding site [nucleotide binding]; other site 536019015356 putative Zn2+ binding site [ion binding]; other site 536019015357 AsnC family; Region: AsnC_trans_reg; pfam01037 536019015358 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 536019015359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 536019015360 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 536019015361 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 536019015362 putative [4Fe-4S] binding site [ion binding]; other site 536019015363 putative molybdopterin cofactor binding site [chemical binding]; other site 536019015364 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 536019015365 molybdopterin cofactor binding site; other site 536019015366 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 536019015367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019015368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019015369 Walker A/P-loop; other site 536019015370 ATP binding site [chemical binding]; other site 536019015371 Q-loop/lid; other site 536019015372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019015373 ABC transporter signature motif; other site 536019015374 Walker B; other site 536019015375 D-loop; other site 536019015376 ABC transporter; Region: ABC_tran_2; pfam12848 536019015377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536019015378 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 536019015379 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019015380 EamA-like transporter family; Region: EamA; pfam00892 536019015381 EamA-like transporter family; Region: EamA; pfam00892 536019015382 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019015383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015384 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019015385 dimerization interface [polypeptide binding]; other site 536019015386 substrate binding pocket [chemical binding]; other site 536019015387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 536019015388 DinB superfamily; Region: DinB_2; pfam12867 536019015389 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 536019015390 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019015391 putative C-terminal domain interface [polypeptide binding]; other site 536019015392 putative GSH binding site (G-site) [chemical binding]; other site 536019015393 putative dimer interface [polypeptide binding]; other site 536019015394 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 536019015395 putative N-terminal domain interface [polypeptide binding]; other site 536019015396 putative dimer interface [polypeptide binding]; other site 536019015397 putative substrate binding pocket (H-site) [chemical binding]; other site 536019015398 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 536019015399 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 536019015400 active site 536019015401 multimer interface [polypeptide binding]; other site 536019015402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 536019015403 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 536019015404 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 536019015405 MoaE homodimer interface [polypeptide binding]; other site 536019015406 MoaD interaction [polypeptide binding]; other site 536019015407 active site residues [active] 536019015408 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 536019015409 MoaE interaction surface [polypeptide binding]; other site 536019015410 MoeB interaction surface [polypeptide binding]; other site 536019015411 thiocarboxylated glycine; other site 536019015412 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 536019015413 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 536019015414 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 536019015415 GIY-YIG motif/motif A; other site 536019015416 active site 536019015417 catalytic site [active] 536019015418 putative DNA binding site [nucleotide binding]; other site 536019015419 metal binding site [ion binding]; metal-binding site 536019015420 UvrB/uvrC motif; Region: UVR; pfam02151 536019015421 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 536019015422 short chain dehydrogenase; Provisional; Region: PRK09134 536019015423 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 536019015424 NADP binding site [chemical binding]; other site 536019015425 substrate binding pocket [chemical binding]; other site 536019015426 active site 536019015427 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 536019015428 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019015429 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 536019015430 putative C-terminal domain interface [polypeptide binding]; other site 536019015431 putative GSH binding site (G-site) [chemical binding]; other site 536019015432 putative dimer interface [polypeptide binding]; other site 536019015433 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 536019015434 dimer interface [polypeptide binding]; other site 536019015435 N-terminal domain interface [polypeptide binding]; other site 536019015436 putative substrate binding pocket (H-site) [chemical binding]; other site 536019015437 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 536019015438 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 536019015439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015441 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 536019015442 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 536019015443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015445 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 536019015446 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 536019015447 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019015448 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 536019015449 NAD binding site [chemical binding]; other site 536019015450 putative substrate binding site 2 [chemical binding]; other site 536019015451 putative substrate binding site 1 [chemical binding]; other site 536019015452 active site 536019015453 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 536019015454 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 536019015455 NAD binding site [chemical binding]; other site 536019015456 homodimer interface [polypeptide binding]; other site 536019015457 active site 536019015458 substrate binding site [chemical binding]; other site 536019015459 Protein of unknown function (DUF995); Region: DUF995; pfam06191 536019015460 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 536019015461 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 536019015462 DXD motif; other site 536019015463 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 536019015464 Protein of unknown function (DUF995); Region: DUF995; pfam06191 536019015465 DNA polymerase III subunit chi; Validated; Region: PRK05728 536019015466 multifunctional aminopeptidase A; Provisional; Region: PRK00913 536019015467 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 536019015468 interface (dimer of trimers) [polypeptide binding]; other site 536019015469 Substrate-binding/catalytic site; other site 536019015470 Zn-binding sites [ion binding]; other site 536019015471 Predicted permeases [General function prediction only]; Region: COG0795 536019015472 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 536019015473 Predicted permeases [General function prediction only]; Region: COG0795 536019015474 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 536019015475 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 536019015476 Organic solvent tolerance protein; Region: OstA_C; pfam04453 536019015477 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 536019015478 SurA N-terminal domain; Region: SurA_N; pfam09312 536019015479 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 536019015480 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 536019015481 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 536019015482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019015483 S-adenosylmethionine binding site [chemical binding]; other site 536019015484 Uncharacterized conserved protein [Function unknown]; Region: COG5470 536019015485 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 536019015486 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 536019015487 catalytic site [active] 536019015488 G-X2-G-X-G-K; other site 536019015489 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 536019015490 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 536019015491 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 536019015492 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 536019015493 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 536019015494 dimerization interface [polypeptide binding]; other site 536019015495 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 536019015496 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019015497 dimer interface [polypeptide binding]; other site 536019015498 active site 536019015499 acyl carrier protein; Provisional; Region: acpP; PRK00982 536019015500 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 536019015501 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 536019015502 NAD(P) binding site [chemical binding]; other site 536019015503 homotetramer interface [polypeptide binding]; other site 536019015504 homodimer interface [polypeptide binding]; other site 536019015505 active site 536019015506 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 536019015507 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 536019015508 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 536019015509 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 536019015510 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 536019015511 Sulfatase; Region: Sulfatase; pfam00884 536019015512 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 536019015513 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 536019015514 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 536019015515 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 536019015516 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 536019015517 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 536019015518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019015519 S-adenosylmethionine binding site [chemical binding]; other site 536019015520 Uncharacterized conserved protein [Function unknown]; Region: COG1742 536019015521 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 536019015522 replicative DNA helicase; Provisional; Region: PRK09165 536019015523 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 536019015524 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 536019015525 Walker A motif; other site 536019015526 ATP binding site [chemical binding]; other site 536019015527 Walker B motif; other site 536019015528 DNA binding loops [nucleotide binding] 536019015529 DNA repair protein RadA; Provisional; Region: PRK11823 536019015530 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 536019015531 Walker A motif; other site 536019015532 ATP binding site [chemical binding]; other site 536019015533 Walker B motif; other site 536019015534 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 536019015535 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 536019015536 Colicin V production protein; Region: Colicin_V; pfam02674 536019015537 amidophosphoribosyltransferase; Provisional; Region: PRK09123 536019015538 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 536019015539 active site 536019015540 tetramer interface [polypeptide binding]; other site 536019015541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019015542 active site 536019015543 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 536019015544 classical (c) SDRs; Region: SDR_c; cd05233 536019015545 NAD(P) binding site [chemical binding]; other site 536019015546 active site 536019015547 OsmC-like protein; Region: OsmC; pfam02566 536019015548 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 536019015549 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 536019015550 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019015551 EamA-like transporter family; Region: EamA; pfam00892 536019015552 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019015553 EamA-like transporter family; Region: EamA; pfam00892 536019015554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019015555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019015557 dimerization interface [polypeptide binding]; other site 536019015558 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 536019015559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 536019015560 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 536019015561 putative acyl-acceptor binding pocket; other site 536019015562 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 536019015563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 536019015564 acyl-activating enzyme (AAE) consensus motif; other site 536019015565 AMP binding site [chemical binding]; other site 536019015566 active site 536019015567 CoA binding site [chemical binding]; other site 536019015568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019015569 NADH(P)-binding; Region: NAD_binding_10; pfam13460 536019015570 NAD(P) binding site [chemical binding]; other site 536019015571 active site 536019015572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015574 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 536019015575 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 536019015576 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 536019015577 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 536019015578 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 536019015579 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 536019015580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019015581 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 536019015582 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 536019015583 Walker A/P-loop; other site 536019015584 ATP binding site [chemical binding]; other site 536019015585 Q-loop/lid; other site 536019015586 ABC transporter signature motif; other site 536019015587 Walker B; other site 536019015588 D-loop; other site 536019015589 H-loop/switch region; other site 536019015590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019015591 dimerization interface [polypeptide binding]; other site 536019015592 putative DNA binding site [nucleotide binding]; other site 536019015593 putative Zn2+ binding site [ion binding]; other site 536019015594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015595 LysR family transcriptional regulator; Provisional; Region: PRK14997 536019015596 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536019015597 putative effector binding pocket; other site 536019015598 dimerization interface [polypeptide binding]; other site 536019015599 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 536019015600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536019015601 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 536019015602 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 536019015603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536019015604 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 536019015605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019015606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015607 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 536019015608 dimerization interface [polypeptide binding]; other site 536019015609 substrate binding pocket [chemical binding]; other site 536019015610 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536019015611 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 536019015612 Cl binding site [ion binding]; other site 536019015613 oligomer interface [polypeptide binding]; other site 536019015614 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 536019015615 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536019015616 putative C-terminal domain interface [polypeptide binding]; other site 536019015617 putative GSH binding site (G-site) [chemical binding]; other site 536019015618 putative dimer interface [polypeptide binding]; other site 536019015619 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 536019015620 putative substrate binding pocket (H-site) [chemical binding]; other site 536019015621 putative N-terminal domain interface [polypeptide binding]; other site 536019015622 Predicted permeases [General function prediction only]; Region: RarD; COG2962 536019015623 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 536019015624 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 536019015625 active site 536019015626 catalytic residues [active] 536019015627 metal binding site [ion binding]; metal-binding site 536019015628 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 536019015629 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 536019015630 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019015631 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019015632 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 536019015633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019015634 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 536019015635 putative active site [active] 536019015636 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 536019015637 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 536019015638 active site 536019015639 HIGH motif; other site 536019015640 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 536019015641 KMSKS motif; other site 536019015642 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 536019015643 Uncharacterized conserved protein [Function unknown]; Region: COG2135 536019015644 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 536019015645 nudix motif; other site 536019015646 TIGR02301 family protein; Region: TIGR02301 536019015647 dihydroorotase; Validated; Region: PRK09060 536019015648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019015649 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 536019015650 active site 536019015651 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 536019015652 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 536019015653 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019015654 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 536019015655 PAS fold; Region: PAS_7; pfam12860 536019015656 PAS fold; Region: PAS_7; pfam12860 536019015657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019015658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019015659 metal binding site [ion binding]; metal-binding site 536019015660 active site 536019015661 I-site; other site 536019015662 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019015663 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 536019015664 Fatty acid desaturase; Region: FA_desaturase; pfam00487 536019015665 putative di-iron ligands [ion binding]; other site 536019015666 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019015667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015668 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019015669 dimerization interface [polypeptide binding]; other site 536019015670 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 536019015671 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 536019015672 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 536019015673 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 536019015674 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 536019015675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019015676 Coenzyme A binding pocket [chemical binding]; other site 536019015677 Peptidase_C39 like family; Region: DUF3335; pfam11814 536019015678 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 536019015679 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 536019015680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019015681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019015682 DNA binding residues [nucleotide binding] 536019015683 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 536019015684 putative active site [active] 536019015685 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 536019015686 Predicted membrane protein [Function unknown]; Region: COG5373 536019015687 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536019015688 CoenzymeA binding site [chemical binding]; other site 536019015689 subunit interaction site [polypeptide binding]; other site 536019015690 PHB binding site; other site 536019015691 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 536019015692 Recombination protein O N terminal; Region: RecO_N; pfam11967 536019015693 Recombination protein O C terminal; Region: RecO_C; pfam02565 536019015694 Porin subfamily; Region: Porin_2; pfam02530 536019015695 CAAX protease self-immunity; Region: Abi; pfam02517 536019015696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019015697 DNA binding site [nucleotide binding] 536019015698 Predicted integral membrane protein [Function unknown]; Region: COG5616 536019015699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015700 TPR motif; other site 536019015701 binding surface 536019015702 TPR repeat; Region: TPR_11; pfam13414 536019015703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015704 TPR motif; other site 536019015705 binding surface 536019015706 GTPase Era; Reviewed; Region: era; PRK00089 536019015707 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 536019015708 G1 box; other site 536019015709 GTP/Mg2+ binding site [chemical binding]; other site 536019015710 Switch I region; other site 536019015711 G2 box; other site 536019015712 Switch II region; other site 536019015713 G3 box; other site 536019015714 G4 box; other site 536019015715 G5 box; other site 536019015716 KH domain; Region: KH_2; pfam07650 536019015717 ribonuclease III; Reviewed; Region: PRK12371 536019015718 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 536019015719 dimerization interface [polypeptide binding]; other site 536019015720 active site 536019015721 metal binding site [ion binding]; metal-binding site 536019015722 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 536019015723 dsRNA binding site [nucleotide binding]; other site 536019015724 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 536019015725 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 536019015726 Catalytic site [active] 536019015727 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 536019015728 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 536019015729 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 536019015730 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 536019015731 dimer interface [polypeptide binding]; other site 536019015732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019015733 metal binding site [ion binding]; metal-binding site 536019015734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536019015735 active site 536019015736 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 536019015737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019015738 Zn2+ binding site [ion binding]; other site 536019015739 Mg2+ binding site [ion binding]; other site 536019015740 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 536019015741 synthetase active site [active] 536019015742 NTP binding site [chemical binding]; other site 536019015743 metal binding site [ion binding]; metal-binding site 536019015744 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 536019015745 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 536019015746 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 536019015747 Uncharacterized conserved protein [Function unknown]; Region: COG1432 536019015748 LabA_like proteins; Region: LabA; cd10911 536019015749 putative metal binding site [ion binding]; other site 536019015750 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 536019015751 Fe-S cluster binding site [ion binding]; other site 536019015752 DNA binding site [nucleotide binding] 536019015753 active site 536019015754 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019015755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019015756 putative DNA binding site [nucleotide binding]; other site 536019015757 putative Zn2+ binding site [ion binding]; other site 536019015758 AsnC family; Region: AsnC_trans_reg; pfam01037 536019015759 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536019015760 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 536019015761 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 536019015762 active site 536019015763 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 536019015764 SmpB-tmRNA interface; other site 536019015765 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 536019015766 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 536019015767 dimer interface [polypeptide binding]; other site 536019015768 active site 536019015769 catalytic residue [active] 536019015770 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019015771 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019015772 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019015773 catalytic residue [active] 536019015774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019015775 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536019015776 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 536019015777 dimer interface [polypeptide binding]; other site 536019015778 active site 536019015779 catalytic residues [active] 536019015780 Int/Topo IB signature motif; other site 536019015781 Porin subfamily; Region: Porin_2; pfam02530 536019015782 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 536019015783 GIY-YIG motif/motif A; other site 536019015784 putative active site [active] 536019015785 putative metal binding site [ion binding]; other site 536019015786 Porin subfamily; Region: Porin_2; pfam02530 536019015787 Tetratricopeptide repeat; Region: TPR_16; pfam13432 536019015788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 536019015789 TPR motif; other site 536019015790 TPR repeat; Region: TPR_11; pfam13414 536019015791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015792 binding surface 536019015793 TPR motif; other site 536019015794 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 536019015795 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 536019015796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015797 binding surface 536019015798 TPR repeat; Region: TPR_11; pfam13414 536019015799 TPR motif; other site 536019015800 TPR repeat; Region: TPR_11; pfam13414 536019015801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015802 TPR motif; other site 536019015803 binding surface 536019015804 TPR repeat; Region: TPR_11; pfam13414 536019015805 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 536019015806 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 536019015807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019015808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019015809 homodimer interface [polypeptide binding]; other site 536019015810 catalytic residue [active] 536019015811 Acylphosphatase; Region: Acylphosphatase; cl00551 536019015812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019015813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019015814 isovaleryl-CoA dehydrogenase; Region: PLN02519 536019015815 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 536019015816 substrate binding site [chemical binding]; other site 536019015817 FAD binding site [chemical binding]; other site 536019015818 catalytic base [active] 536019015819 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 536019015820 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 536019015821 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 536019015822 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 536019015823 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536019015824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019015825 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536019015826 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536019015827 carboxyltransferase (CT) interaction site; other site 536019015828 biotinylation site [posttranslational modification]; other site 536019015829 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019015830 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 536019015831 dimerization interface [polypeptide binding]; other site 536019015832 ligand binding site [chemical binding]; other site 536019015833 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536019015834 Sel1 repeat; Region: Sel1; cl02723 536019015835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 536019015836 AMP nucleosidase; Provisional; Region: PRK08292 536019015837 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 536019015838 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 536019015839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 536019015840 putative catalytic site [active] 536019015841 putative metal binding site [ion binding]; other site 536019015842 putative phosphate binding site [ion binding]; other site 536019015843 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 536019015844 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 536019015845 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019015846 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 536019015847 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 536019015848 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 536019015849 Fe-S cluster binding site [ion binding]; other site 536019015850 active site 536019015851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019015852 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019015853 non-specific DNA binding site [nucleotide binding]; other site 536019015854 salt bridge; other site 536019015855 sequence-specific DNA binding site [nucleotide binding]; other site 536019015856 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536019015857 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 536019015858 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536019015859 aminopeptidase N; Provisional; Region: pepN; PRK14015 536019015860 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 536019015861 active site 536019015862 Zn binding site [ion binding]; other site 536019015863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019015864 PAS fold; Region: PAS_3; pfam08447 536019015865 putative active site [active] 536019015866 heme pocket [chemical binding]; other site 536019015867 PAS fold; Region: PAS_7; pfam12860 536019015868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019015869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019015870 dimer interface [polypeptide binding]; other site 536019015871 phosphorylation site [posttranslational modification] 536019015872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019015873 ATP binding site [chemical binding]; other site 536019015874 Mg2+ binding site [ion binding]; other site 536019015875 G-X-G motif; other site 536019015876 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 536019015877 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 536019015878 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536019015879 metal binding triad; other site 536019015880 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536019015881 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536019015882 metal binding triad; other site 536019015883 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536019015884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536019015885 dimerization interface [polypeptide binding]; other site 536019015886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019015887 dimer interface [polypeptide binding]; other site 536019015888 phosphorylation site [posttranslational modification] 536019015889 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 536019015890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019015891 ATP binding site [chemical binding]; other site 536019015892 Mg2+ binding site [ion binding]; other site 536019015893 G-X-G motif; other site 536019015894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019015895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019015896 active site 536019015897 phosphorylation site [posttranslational modification] 536019015898 intermolecular recognition site; other site 536019015899 dimerization interface [polypeptide binding]; other site 536019015900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019015901 DNA binding site [nucleotide binding] 536019015902 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 536019015903 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536019015904 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019015905 protein binding site [polypeptide binding]; other site 536019015906 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536019015907 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 536019015908 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 536019015909 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 536019015910 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 536019015911 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 536019015912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019015913 binding surface 536019015914 TPR motif; other site 536019015915 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 536019015916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019015917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019015918 ATP binding site [chemical binding]; other site 536019015919 G-X-G motif; other site 536019015920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019015921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019015922 active site 536019015923 phosphorylation site [posttranslational modification] 536019015924 intermolecular recognition site; other site 536019015925 dimerization interface [polypeptide binding]; other site 536019015926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019015927 DNA binding site [nucleotide binding] 536019015928 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 536019015929 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 536019015930 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 536019015931 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 536019015932 active site 536019015933 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019015934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019015935 dimer interface [polypeptide binding]; other site 536019015936 conserved gate region; other site 536019015937 putative PBP binding loops; other site 536019015938 ABC-ATPase subunit interface; other site 536019015939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019015940 putative PBP binding loops; other site 536019015941 dimer interface [polypeptide binding]; other site 536019015942 ABC-ATPase subunit interface; other site 536019015943 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019015944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019015945 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019015946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019015947 Walker A/P-loop; other site 536019015948 ATP binding site [chemical binding]; other site 536019015949 Q-loop/lid; other site 536019015950 ABC transporter signature motif; other site 536019015951 Walker B; other site 536019015952 D-loop; other site 536019015953 H-loop/switch region; other site 536019015954 TOBE domain; Region: TOBE_2; pfam08402 536019015955 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019015956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019015957 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019015958 dimerization interface [polypeptide binding]; other site 536019015959 substrate binding pocket [chemical binding]; other site 536019015960 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 536019015961 amidohydrolase; Region: amidohydrolases; TIGR01891 536019015962 metal binding site [ion binding]; metal-binding site 536019015963 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 536019015964 Amidinotransferase; Region: Amidinotransf; pfam02274 536019015965 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 536019015966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019015967 non-specific DNA binding site [nucleotide binding]; other site 536019015968 salt bridge; other site 536019015969 sequence-specific DNA binding site [nucleotide binding]; other site 536019015970 Cupin domain; Region: Cupin_2; pfam07883 536019015971 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019015972 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019015973 ligand binding site [chemical binding]; other site 536019015974 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019015975 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019015976 Walker A/P-loop; other site 536019015977 ATP binding site [chemical binding]; other site 536019015978 Q-loop/lid; other site 536019015979 ABC transporter signature motif; other site 536019015980 Walker B; other site 536019015981 D-loop; other site 536019015982 H-loop/switch region; other site 536019015983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019015984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019015985 TM-ABC transporter signature motif; other site 536019015986 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 536019015987 active site 536019015988 substrate binding pocket [chemical binding]; other site 536019015989 homodimer interaction site [polypeptide binding]; other site 536019015990 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 536019015991 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019015992 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 536019015993 substrate binding site [chemical binding]; other site 536019015994 dimer interface [polypeptide binding]; other site 536019015995 ATP binding site [chemical binding]; other site 536019015996 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 536019015997 allantoate amidohydrolase; Reviewed; Region: PRK12893 536019015998 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 536019015999 active site 536019016000 metal binding site [ion binding]; metal-binding site 536019016001 dimer interface [polypeptide binding]; other site 536019016002 Transglycosylase; Region: Transgly; pfam00912 536019016003 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 536019016004 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 536019016005 Uncharacterized conserved protein [Function unknown]; Region: COG5402 536019016006 Predicted integral membrane protein [Function unknown]; Region: COG5436 536019016007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 536019016008 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 536019016009 Uncharacterized conserved protein [Function unknown]; Region: COG5447 536019016010 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 536019016011 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019016012 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019016013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016014 putative active site [active] 536019016015 heme pocket [chemical binding]; other site 536019016016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019016017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019016018 dimer interface [polypeptide binding]; other site 536019016019 phosphorylation site [posttranslational modification] 536019016020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019016021 ATP binding site [chemical binding]; other site 536019016022 Mg2+ binding site [ion binding]; other site 536019016023 G-X-G motif; other site 536019016024 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 536019016025 Predicted transcriptional regulator [Transcription]; Region: COG4957 536019016026 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 536019016027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019016028 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 536019016029 Proteins containing SET domain [General function prediction only]; Region: COG2940 536019016030 SET domain; Region: SET; pfam00856 536019016031 Cytochrome c; Region: Cytochrom_C; pfam00034 536019016032 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 536019016033 Cytochrome C' Region: Cytochrom_C_2; cl01610 536019016034 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 536019016035 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 536019016036 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 536019016037 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536019016038 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 536019016039 homodimer interface [polypeptide binding]; other site 536019016040 substrate-cofactor binding pocket; other site 536019016041 catalytic residue [active] 536019016042 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 536019016043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019016044 motif II; other site 536019016045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 536019016046 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019016047 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 536019016048 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 536019016049 heterodimer interface [polypeptide binding]; other site 536019016050 substrate interaction site [chemical binding]; other site 536019016051 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 536019016052 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 536019016053 active site 536019016054 substrate binding site [chemical binding]; other site 536019016055 coenzyme B12 binding site [chemical binding]; other site 536019016056 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 536019016057 B12 binding site [chemical binding]; other site 536019016058 cobalt ligand [ion binding]; other site 536019016059 putative addiction module antidote; Region: doc_partner; TIGR02609 536019016060 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 536019016061 transcription elongation factor regulatory protein; Validated; Region: PRK06342 536019016062 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536019016063 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 536019016064 L-asparaginase II; Region: Asparaginase_II; cl01842 536019016065 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 536019016066 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 536019016067 active site 536019016068 transcriptional regulator BetI; Validated; Region: PRK00767 536019016069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019016070 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536019016071 choline-sulfatase; Region: chol_sulfatase; TIGR03417 536019016072 Sulfatase; Region: Sulfatase; cl17466 536019016073 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 536019016074 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536019016075 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536019016076 tetramer interface [polypeptide binding]; other site 536019016077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019016078 catalytic residue [active] 536019016079 choline dehydrogenase; Validated; Region: PRK02106 536019016080 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019016081 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 536019016082 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 536019016083 tetrameric interface [polypeptide binding]; other site 536019016084 NAD binding site [chemical binding]; other site 536019016085 catalytic residues [active] 536019016086 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 536019016087 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 536019016088 Substrate binding site; other site 536019016089 Cupin domain; Region: Cupin_2; cl17218 536019016090 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 536019016091 dimerization interface [polypeptide binding]; other site 536019016092 putative active cleft [active] 536019016093 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 536019016094 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 536019016095 active site 536019016096 substrate binding site [chemical binding]; other site 536019016097 metal binding site [ion binding]; metal-binding site 536019016098 DNA helicase, putative; Region: TIGR00376 536019016099 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 536019016100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019016101 Walker A/P-loop; other site 536019016102 ATP binding site [chemical binding]; other site 536019016103 Q-loop/lid; other site 536019016104 ABC transporter signature motif; other site 536019016105 Walker B; other site 536019016106 D-loop; other site 536019016107 H-loop/switch region; other site 536019016108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019016109 Walker A/P-loop; other site 536019016110 ATP binding site [chemical binding]; other site 536019016111 Q-loop/lid; other site 536019016112 ABC transporter signature motif; other site 536019016113 Walker B; other site 536019016114 D-loop; other site 536019016115 H-loop/switch region; other site 536019016116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019016117 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536019016118 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 536019016119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016120 dimer interface [polypeptide binding]; other site 536019016121 conserved gate region; other site 536019016122 putative PBP binding loops; other site 536019016123 ABC-ATPase subunit interface; other site 536019016124 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 536019016125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016126 dimer interface [polypeptide binding]; other site 536019016127 conserved gate region; other site 536019016128 putative PBP binding loops; other site 536019016129 ABC-ATPase subunit interface; other site 536019016130 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 536019016131 peptide binding site [polypeptide binding]; other site 536019016132 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 536019016133 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019016134 Predicted membrane protein [Function unknown]; Region: COG4655 536019016135 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 536019016136 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 536019016137 active site 536019016138 catalytic site [active] 536019016139 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 536019016140 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 536019016141 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 536019016142 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 536019016143 active site 536019016144 catalytic site [active] 536019016145 phosphoglucomutase; Region: PLN02307 536019016146 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 536019016147 substrate binding site [chemical binding]; other site 536019016148 dimer interface [polypeptide binding]; other site 536019016149 active site 536019016150 metal binding site [ion binding]; metal-binding site 536019016151 glycogen synthase; Provisional; Region: glgA; PRK00654 536019016152 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 536019016153 ADP-binding pocket [chemical binding]; other site 536019016154 homodimer interface [polypeptide binding]; other site 536019016155 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 536019016156 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 536019016157 ligand binding site; other site 536019016158 oligomer interface; other site 536019016159 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 536019016160 dimer interface [polypeptide binding]; other site 536019016161 N-terminal domain interface [polypeptide binding]; other site 536019016162 sulfate 1 binding site; other site 536019016163 glycogen branching enzyme; Provisional; Region: PRK05402 536019016164 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 536019016165 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 536019016166 active site 536019016167 catalytic site [active] 536019016168 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 536019016169 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 536019016170 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 536019016171 homodimer interface [polypeptide binding]; other site 536019016172 active site pocket [active] 536019016173 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019016174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019016175 Walker A/P-loop; other site 536019016176 ATP binding site [chemical binding]; other site 536019016177 Q-loop/lid; other site 536019016178 ABC transporter signature motif; other site 536019016179 Walker B; other site 536019016180 D-loop; other site 536019016181 H-loop/switch region; other site 536019016182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019016183 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019016184 TM-ABC transporter signature motif; other site 536019016185 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536019016186 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019016187 ligand binding site [chemical binding]; other site 536019016188 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019016189 DNA binding site [nucleotide binding] 536019016190 sequence specific DNA binding site [nucleotide binding]; other site 536019016191 putative cAMP binding site [chemical binding]; other site 536019016192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019016193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019016194 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 536019016195 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019016196 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 536019016197 putative substrate binding site [chemical binding]; other site 536019016198 putative ATP binding site [chemical binding]; other site 536019016199 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 536019016200 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 536019016201 inhibitor-cofactor binding pocket; inhibition site 536019016202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019016203 catalytic residue [active] 536019016204 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 536019016205 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536019016206 active site 536019016207 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 536019016208 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 536019016209 CysD dimerization site [polypeptide binding]; other site 536019016210 G1 box; other site 536019016211 putative GEF interaction site [polypeptide binding]; other site 536019016212 GTP/Mg2+ binding site [chemical binding]; other site 536019016213 Switch I region; other site 536019016214 G2 box; other site 536019016215 G3 box; other site 536019016216 Switch II region; other site 536019016217 G4 box; other site 536019016218 G5 box; other site 536019016219 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 536019016220 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 536019016221 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 536019016222 ligand-binding site [chemical binding]; other site 536019016223 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 536019016224 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536019016225 Active Sites [active] 536019016226 O-Antigen ligase; Region: Wzy_C; pfam04932 536019016227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019016228 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 536019016229 NAD(P) binding site [chemical binding]; other site 536019016230 active site 536019016231 Bacterial sugar transferase; Region: Bac_transf; pfam02397 536019016232 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 536019016233 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 536019016234 NAD(P) binding site [chemical binding]; other site 536019016235 homodimer interface [polypeptide binding]; other site 536019016236 substrate binding site [chemical binding]; other site 536019016237 active site 536019016238 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 536019016239 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 536019016240 NADP binding site [chemical binding]; other site 536019016241 active site 536019016242 putative substrate binding site [chemical binding]; other site 536019016243 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 536019016244 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 536019016245 NAD binding site [chemical binding]; other site 536019016246 substrate binding site [chemical binding]; other site 536019016247 homodimer interface [polypeptide binding]; other site 536019016248 active site 536019016249 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 536019016250 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 536019016251 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 536019016252 substrate binding site; other site 536019016253 tetramer interface; other site 536019016254 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019016255 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 536019016256 putative NAD(P) binding site [chemical binding]; other site 536019016257 active site 536019016258 putative substrate binding site [chemical binding]; other site 536019016259 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 536019016260 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536019016261 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 536019016262 putative acyl-CoA synthetase; Provisional; Region: PRK06018 536019016263 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 536019016264 dimer interface [polypeptide binding]; other site 536019016265 acyl-activating enzyme (AAE) consensus motif; other site 536019016266 putative active site [active] 536019016267 AMP binding site [chemical binding]; other site 536019016268 putative CoA binding site [chemical binding]; other site 536019016269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 536019016270 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 536019016271 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 536019016272 NodB motif; other site 536019016273 putative active site [active] 536019016274 putative catalytic site [active] 536019016275 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536019016276 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536019016277 putative active site [active] 536019016278 pyruvate phosphate dikinase; Provisional; Region: PRK09279 536019016279 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 536019016280 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536019016281 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536019016282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536019016283 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 536019016284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019016285 salt bridge; other site 536019016286 non-specific DNA binding site [nucleotide binding]; other site 536019016287 sequence-specific DNA binding site [nucleotide binding]; other site 536019016288 Abortive infection C-terminus; Region: Abi_C; pfam14355 536019016289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019016290 AAA domain; Region: AAA_21; pfam13304 536019016291 Walker A/P-loop; other site 536019016292 ATP binding site [chemical binding]; other site 536019016293 Q-loop/lid; other site 536019016294 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 536019016295 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 536019016296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019016297 FeS/SAM binding site; other site 536019016298 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 536019016299 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 536019016300 HEXXH motif domain; Region: mod_HExxH; TIGR04267 536019016301 TIGR02646 family protein; Region: TIGR02646 536019016302 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 536019016303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019016304 Walker A/P-loop; other site 536019016305 ATP binding site [chemical binding]; other site 536019016306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019016307 DNA-binding site [nucleotide binding]; DNA binding site 536019016308 RNA-binding motif; other site 536019016309 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019016310 DNA-binding site [nucleotide binding]; DNA binding site 536019016311 RNA-binding motif; other site 536019016312 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 536019016313 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 536019016314 dimer interface [polypeptide binding]; other site 536019016315 putative functional site; other site 536019016316 putative MPT binding site; other site 536019016317 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019016318 Cytochrome P450; Region: p450; cl12078 536019016319 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 536019016320 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 536019016321 MobA/MobL family; Region: MobA_MobL; pfam03389 536019016322 AAA domain; Region: AAA_30; pfam13604 536019016323 Family description; Region: UvrD_C_2; pfam13538 536019016324 Conjugal transfer protein TraD; Region: TraD; pfam06412 536019016325 Conjugal transfer protein TraD; Region: TraD; pfam06412 536019016326 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 536019016327 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 536019016328 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536019016329 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 536019016330 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 536019016331 dimerization interface [polypeptide binding]; other site 536019016332 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 536019016333 ATP binding site [chemical binding]; other site 536019016334 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 536019016335 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 536019016336 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 536019016337 dimer interface [polypeptide binding]; other site 536019016338 active site 536019016339 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 536019016340 Acylphosphatase; Region: Acylphosphatase; pfam00708 536019016341 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 536019016342 HypF finger; Region: zf-HYPF; pfam07503 536019016343 HypF finger; Region: zf-HYPF; pfam07503 536019016344 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 536019016345 NifU-like domain; Region: NifU; cl00484 536019016346 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 536019016347 iron-sulfur cluster [ion binding]; other site 536019016348 [2Fe-2S] cluster binding site [ion binding]; other site 536019016349 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 536019016350 nickel binding site [ion binding]; other site 536019016351 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 536019016352 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 536019016353 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 536019016354 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 536019016355 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 536019016356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 536019016357 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 536019016358 active site 536019016359 phosphorylation site [posttranslational modification] 536019016360 intermolecular recognition site; other site 536019016361 dimerization interface [polypeptide binding]; other site 536019016362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019016363 Walker A motif; other site 536019016364 ATP binding site [chemical binding]; other site 536019016365 Walker B motif; other site 536019016366 arginine finger; other site 536019016367 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019016368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019016369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019016370 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 536019016371 putative dimerization interface [polypeptide binding]; other site 536019016372 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 536019016373 AMP binding site [chemical binding]; other site 536019016374 metal binding site [ion binding]; metal-binding site 536019016375 active site 536019016376 phosphoribulokinase; Provisional; Region: PRK15453 536019016377 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 536019016378 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 536019016379 TPP-binding site [chemical binding]; other site 536019016380 dimer interface [polypeptide binding]; other site 536019016381 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536019016382 PYR/PP interface [polypeptide binding]; other site 536019016383 dimer interface [polypeptide binding]; other site 536019016384 TPP binding site [chemical binding]; other site 536019016385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019016386 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 536019016387 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 536019016388 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 536019016389 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 536019016390 Phosphoglycerate kinase; Region: PGK; pfam00162 536019016391 substrate binding site [chemical binding]; other site 536019016392 hinge regions; other site 536019016393 ADP binding site [chemical binding]; other site 536019016394 catalytic site [active] 536019016395 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 536019016396 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 536019016397 intersubunit interface [polypeptide binding]; other site 536019016398 active site 536019016399 zinc binding site [ion binding]; other site 536019016400 Na+ binding site [ion binding]; other site 536019016401 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 536019016402 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 536019016403 homodimer interface [polypeptide binding]; other site 536019016404 active site 536019016405 heterodimer interface [polypeptide binding]; other site 536019016406 catalytic residue [active] 536019016407 metal binding site [ion binding]; metal-binding site 536019016408 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 536019016409 multimerization interface [polypeptide binding]; other site 536019016410 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 536019016411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019016412 Walker A motif; other site 536019016413 ATP binding site [chemical binding]; other site 536019016414 Walker B motif; other site 536019016415 arginine finger; other site 536019016416 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 536019016417 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536019016418 substrate binding site [chemical binding]; other site 536019016419 hexamer interface [polypeptide binding]; other site 536019016420 metal binding site [ion binding]; metal-binding site 536019016421 phosphoglycolate phosphatase; Provisional; Region: PRK13222 536019016422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019016423 motif II; other site 536019016424 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019016425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019016426 motif II; other site 536019016427 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 536019016428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019016429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536019016430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019016431 short chain dehydrogenase; Provisional; Region: PRK06180 536019016432 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536019016433 NADP binding site [chemical binding]; other site 536019016434 active site 536019016435 steroid binding site; other site 536019016436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019016437 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 536019016438 C-terminal domain interface [polypeptide binding]; other site 536019016439 GSH binding site (G-site) [chemical binding]; other site 536019016440 dimer interface [polypeptide binding]; other site 536019016441 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 536019016442 dimer interface [polypeptide binding]; other site 536019016443 N-terminal domain interface [polypeptide binding]; other site 536019016444 substrate binding pocket (H-site) [chemical binding]; other site 536019016445 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 536019016446 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 536019016447 [2Fe-2S] cluster binding site [ion binding]; other site 536019016448 cytochrome b; Provisional; Region: CYTB; MTH00119 536019016449 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 536019016450 Qi binding site; other site 536019016451 intrachain domain interface; other site 536019016452 interchain domain interface [polypeptide binding]; other site 536019016453 heme bH binding site [chemical binding]; other site 536019016454 heme bL binding site [chemical binding]; other site 536019016455 Qo binding site; other site 536019016456 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 536019016457 interchain domain interface [polypeptide binding]; other site 536019016458 intrachain domain interface; other site 536019016459 Qi binding site; other site 536019016460 Qo binding site; other site 536019016461 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 536019016462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536019016463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019016464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019016465 ligand binding site [chemical binding]; other site 536019016466 flexible hinge region; other site 536019016467 Pirin-related protein [General function prediction only]; Region: COG1741 536019016468 Pirin; Region: Pirin; pfam02678 536019016469 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 536019016470 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 536019016471 Predicted acetyltransferase [General function prediction only]; Region: COG2388 536019016472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019016473 ATP binding site [chemical binding]; other site 536019016474 Mg2+ binding site [ion binding]; other site 536019016475 G-X-G motif; other site 536019016476 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 536019016477 FOG: CBS domain [General function prediction only]; Region: COG0517 536019016478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536019016479 Zn2+ binding site [ion binding]; other site 536019016480 Mg2+ binding site [ion binding]; other site 536019016481 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 536019016482 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536019016483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019016484 NAD(P) binding site [chemical binding]; other site 536019016485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019016486 active site 536019016487 active site 536019016488 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019016489 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 536019016490 Protein of unknown function (DUF680); Region: DUF680; pfam05079 536019016491 short chain dehydrogenase; Provisional; Region: PRK06500 536019016492 classical (c) SDRs; Region: SDR_c; cd05233 536019016493 NAD(P) binding site [chemical binding]; other site 536019016494 active site 536019016495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019016496 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019016497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019016498 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019016499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536019016500 PGAP1-like protein; Region: PGAP1; pfam07819 536019016501 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 536019016502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019016503 active site 536019016504 phosphorylation site [posttranslational modification] 536019016505 intermolecular recognition site; other site 536019016506 dimerization interface [polypeptide binding]; other site 536019016507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019016508 DNA binding residues [nucleotide binding] 536019016509 dimerization interface [polypeptide binding]; other site 536019016510 Response regulator receiver domain; Region: Response_reg; pfam00072 536019016511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019016512 active site 536019016513 phosphorylation site [posttranslational modification] 536019016514 intermolecular recognition site; other site 536019016515 dimerization interface [polypeptide binding]; other site 536019016516 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 536019016517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019016518 active site 536019016519 phosphorylation site [posttranslational modification] 536019016520 intermolecular recognition site; other site 536019016521 dimerization interface [polypeptide binding]; other site 536019016522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019016523 DNA binding residues [nucleotide binding] 536019016524 dimerization interface [polypeptide binding]; other site 536019016525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016526 putative active site [active] 536019016527 PAS fold; Region: PAS_3; pfam08447 536019016528 heme pocket [chemical binding]; other site 536019016529 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 536019016530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016531 putative active site [active] 536019016532 heme pocket [chemical binding]; other site 536019016533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016534 putative active site [active] 536019016535 heme pocket [chemical binding]; other site 536019016536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016537 PAS fold; Region: PAS_3; pfam08447 536019016538 putative active site [active] 536019016539 heme pocket [chemical binding]; other site 536019016540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016541 PAS domain; Region: PAS_9; pfam13426 536019016542 putative active site [active] 536019016543 heme pocket [chemical binding]; other site 536019016544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016545 PAS fold; Region: PAS_3; pfam08447 536019016546 putative active site [active] 536019016547 heme pocket [chemical binding]; other site 536019016548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016549 PAS fold; Region: PAS_3; pfam08447 536019016550 putative active site [active] 536019016551 heme pocket [chemical binding]; other site 536019016552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019016553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019016554 dimer interface [polypeptide binding]; other site 536019016555 phosphorylation site [posttranslational modification] 536019016556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019016557 ATP binding site [chemical binding]; other site 536019016558 Mg2+ binding site [ion binding]; other site 536019016559 G-X-G motif; other site 536019016560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019016561 putative substrate translocation pore; other site 536019016562 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536019016563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019016564 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019016565 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 536019016566 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 536019016567 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 536019016568 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019016569 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019016570 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 536019016571 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 536019016572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019016573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019016574 Walker A/P-loop; other site 536019016575 ATP binding site [chemical binding]; other site 536019016576 Q-loop/lid; other site 536019016577 ABC transporter signature motif; other site 536019016578 Walker B; other site 536019016579 D-loop; other site 536019016580 H-loop/switch region; other site 536019016581 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 536019016582 O-Antigen ligase; Region: Wzy_C; pfam04932 536019016583 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 536019016584 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 536019016585 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 536019016586 Walker A/P-loop; other site 536019016587 ATP binding site [chemical binding]; other site 536019016588 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 536019016589 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 536019016590 ABC transporter signature motif; other site 536019016591 Walker B; other site 536019016592 D-loop; other site 536019016593 H-loop/switch region; other site 536019016594 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 536019016595 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 536019016596 catalytic residues [active] 536019016597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 536019016598 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 536019016599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536019016600 minor groove reading motif; other site 536019016601 helix-hairpin-helix signature motif; other site 536019016602 substrate binding pocket [chemical binding]; other site 536019016603 active site 536019016604 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 536019016605 DNA binding and oxoG recognition site [nucleotide binding] 536019016606 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 536019016607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019016608 motif II; other site 536019016609 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 536019016610 DNA methylase; Region: N6_N4_Mtase; pfam01555 536019016611 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 536019016612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019016613 motif II; other site 536019016614 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 536019016615 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 536019016616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019016617 catalytic residue [active] 536019016618 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536019016619 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 536019016620 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536019016621 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 536019016622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536019016623 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 536019016624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019016625 PAS fold; Region: PAS_3; pfam08447 536019016626 putative active site [active] 536019016627 heme pocket [chemical binding]; other site 536019016628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536019016629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536019016630 metal binding site [ion binding]; metal-binding site 536019016631 active site 536019016632 I-site; other site 536019016633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536019016634 hypothetical protein; Validated; Region: PRK00228 536019016635 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 536019016636 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 536019016637 catalytic triad [active] 536019016638 dimer interface [polypeptide binding]; other site 536019016639 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 536019016640 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 536019016641 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 536019016642 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 536019016643 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 536019016644 RNA/DNA hybrid binding site [nucleotide binding]; other site 536019016645 active site 536019016646 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 536019016647 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 536019016648 putative active site [active] 536019016649 putative substrate binding site [chemical binding]; other site 536019016650 ATP binding site [chemical binding]; other site 536019016651 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 536019016652 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 536019016653 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 536019016654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 536019016655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 536019016656 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536019016657 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 536019016658 Subunit III/VIIa interface [polypeptide binding]; other site 536019016659 Phospholipid binding site [chemical binding]; other site 536019016660 Subunit I/III interface [polypeptide binding]; other site 536019016661 Subunit III/VIb interface [polypeptide binding]; other site 536019016662 Subunit III/VIa interface; other site 536019016663 Subunit III/Vb interface [polypeptide binding]; other site 536019016664 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 536019016665 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 536019016666 UbiA prenyltransferase family; Region: UbiA; pfam01040 536019016667 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536019016668 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 536019016669 Subunit I/III interface [polypeptide binding]; other site 536019016670 D-pathway; other site 536019016671 Subunit I/VIIc interface [polypeptide binding]; other site 536019016672 Subunit I/IV interface [polypeptide binding]; other site 536019016673 Subunit I/II interface [polypeptide binding]; other site 536019016674 Low-spin heme (heme a) binding site [chemical binding]; other site 536019016675 Subunit I/VIIa interface [polypeptide binding]; other site 536019016676 Subunit I/VIa interface [polypeptide binding]; other site 536019016677 Dimer interface; other site 536019016678 Putative water exit pathway; other site 536019016679 Binuclear center (heme a3/CuB) [ion binding]; other site 536019016680 K-pathway; other site 536019016681 Subunit I/Vb interface [polypeptide binding]; other site 536019016682 Putative proton exit pathway; other site 536019016683 Subunit I/VIb interface; other site 536019016684 Subunit I/VIc interface [polypeptide binding]; other site 536019016685 Electron transfer pathway; other site 536019016686 Subunit I/VIIIb interface [polypeptide binding]; other site 536019016687 Subunit I/VIIb interface [polypeptide binding]; other site 536019016688 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 536019016689 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 536019016690 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536019016691 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 536019016692 protease TldD; Provisional; Region: tldD; PRK10735 536019016693 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 536019016694 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 536019016695 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 536019016696 putative active site [active] 536019016697 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 536019016698 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 536019016699 Caspase domain; Region: Peptidase_C14; pfam00656 536019016700 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 536019016701 TRAM domain; Region: TRAM; cl01282 536019016702 Methyltransferase domain; Region: Methyltransf_26; pfam13659 536019016703 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 536019016704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536019016705 RNA binding surface [nucleotide binding]; other site 536019016706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019016707 S-adenosylmethionine binding site [chemical binding]; other site 536019016708 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 536019016709 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 536019016710 TPP-binding site; other site 536019016711 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536019016712 PYR/PP interface [polypeptide binding]; other site 536019016713 dimer interface [polypeptide binding]; other site 536019016714 TPP binding site [chemical binding]; other site 536019016715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536019016716 Pirin-related protein [General function prediction only]; Region: COG1741 536019016717 Pirin; Region: Pirin; pfam02678 536019016718 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 536019016719 Uncharacterized conserved protein [Function unknown]; Region: COG5552 536019016720 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 536019016721 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 536019016722 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 536019016723 putative active site [active] 536019016724 Zn binding site [ion binding]; other site 536019016725 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 536019016726 putative FMN binding site [chemical binding]; other site 536019016727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019016728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019016729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536019016730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019016731 putative substrate translocation pore; other site 536019016732 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 536019016733 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 536019016734 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 536019016735 dimerization interface [polypeptide binding]; other site 536019016736 active site 536019016737 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 536019016738 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 536019016739 Tetramer interface [polypeptide binding]; other site 536019016740 active site 536019016741 FMN-binding site [chemical binding]; other site 536019016742 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 536019016743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019016744 catalytic core [active] 536019016745 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 536019016746 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 536019016747 NAD binding site [chemical binding]; other site 536019016748 homotetramer interface [polypeptide binding]; other site 536019016749 homodimer interface [polypeptide binding]; other site 536019016750 substrate binding site [chemical binding]; other site 536019016751 active site 536019016752 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 536019016753 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536019016754 HSP70 interaction site [polypeptide binding]; other site 536019016755 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 536019016756 substrate binding site [polypeptide binding]; other site 536019016757 dimer interface [polypeptide binding]; other site 536019016758 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 536019016759 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 536019016760 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 536019016761 enoyl-CoA hydratase; Provisional; Region: PRK06688 536019016762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019016763 substrate binding site [chemical binding]; other site 536019016764 oxyanion hole (OAH) forming residues; other site 536019016765 trimer interface [polypeptide binding]; other site 536019016766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019016767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 536019016768 active site 536019016769 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 536019016770 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 536019016771 active site 536019016772 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 536019016773 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 536019016774 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 536019016775 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 536019016776 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 536019016777 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 536019016778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019016779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019016780 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 536019016781 putative substrate binding pocket [chemical binding]; other site 536019016782 dimerization interface [polypeptide binding]; other site 536019016783 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 536019016784 UbiA prenyltransferase family; Region: UbiA; pfam01040 536019016785 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019016786 FAD binding domain; Region: FAD_binding_4; pfam01565 536019016787 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 536019016788 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 536019016789 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 536019016790 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 536019016791 dimer interface [polypeptide binding]; other site 536019016792 motif 1; other site 536019016793 active site 536019016794 motif 2; other site 536019016795 motif 3; other site 536019016796 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536019016797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019016798 Coenzyme A binding pocket [chemical binding]; other site 536019016799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019016800 TPR motif; other site 536019016801 binding surface 536019016802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019016803 binding surface 536019016804 TPR motif; other site 536019016805 TPR repeat; Region: TPR_11; pfam13414 536019016806 TPR repeat; Region: TPR_11; pfam13414 536019016807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019016808 binding surface 536019016809 TPR motif; other site 536019016810 Uncharacterized conserved protein [Function unknown]; Region: COG3543 536019016811 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 536019016812 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019016813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019016814 DNA-binding site [nucleotide binding]; DNA binding site 536019016815 FCD domain; Region: FCD; pfam07729 536019016816 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 536019016817 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 536019016818 substrate binding pocket [chemical binding]; other site 536019016819 chain length determination region; other site 536019016820 substrate-Mg2+ binding site; other site 536019016821 catalytic residues [active] 536019016822 aspartate-rich region 1; other site 536019016823 active site lid residues [active] 536019016824 aspartate-rich region 2; other site 536019016825 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 536019016826 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 536019016827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019016828 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 536019016829 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 536019016830 tandem repeat interface [polypeptide binding]; other site 536019016831 oligomer interface [polypeptide binding]; other site 536019016832 active site residues [active] 536019016833 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 536019016834 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 536019016835 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 536019016836 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 536019016837 MPT binding site; other site 536019016838 trimer interface [polypeptide binding]; other site 536019016839 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 536019016840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536019016841 active site 536019016842 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 536019016843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019016844 FeS/SAM binding site; other site 536019016845 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 536019016846 RNA/DNA hybrid binding site [nucleotide binding]; other site 536019016847 active site 536019016848 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 536019016849 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 536019016850 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 536019016851 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 536019016852 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 536019016853 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 536019016854 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 536019016855 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 536019016856 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 536019016857 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019016858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019016859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019016860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019016861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019016862 dimerization interface [polypeptide binding]; other site 536019016863 GTP-binding protein Der; Reviewed; Region: PRK00093 536019016864 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 536019016865 G1 box; other site 536019016866 GTP/Mg2+ binding site [chemical binding]; other site 536019016867 Switch I region; other site 536019016868 G2 box; other site 536019016869 Switch II region; other site 536019016870 G3 box; other site 536019016871 G4 box; other site 536019016872 G5 box; other site 536019016873 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 536019016874 G1 box; other site 536019016875 GTP/Mg2+ binding site [chemical binding]; other site 536019016876 Switch I region; other site 536019016877 G2 box; other site 536019016878 G3 box; other site 536019016879 Switch II region; other site 536019016880 G4 box; other site 536019016881 G5 box; other site 536019016882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 536019016883 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 536019016884 NodB motif; other site 536019016885 putative active site [active] 536019016886 putative catalytic site [active] 536019016887 microcin B17 transporter; Reviewed; Region: PRK11098 536019016888 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 536019016889 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536019016890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019016891 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536019016892 dimerization interface [polypeptide binding]; other site 536019016893 substrate binding pocket [chemical binding]; other site 536019016894 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 536019016895 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 536019016896 Uncharacterized conserved protein [Function unknown]; Region: COG3189 536019016897 ArsC family; Region: ArsC; pfam03960 536019016898 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 536019016899 putative catalytic residues [active] 536019016900 SnoaL-like domain; Region: SnoaL_2; pfam12680 536019016901 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 536019016902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019016903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019016904 Walker A/P-loop; other site 536019016905 ATP binding site [chemical binding]; other site 536019016906 Q-loop/lid; other site 536019016907 ABC transporter signature motif; other site 536019016908 Walker B; other site 536019016909 D-loop; other site 536019016910 H-loop/switch region; other site 536019016911 TOBE domain; Region: TOBE_2; pfam08402 536019016912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019016913 sequence-specific DNA binding site [nucleotide binding]; other site 536019016914 salt bridge; other site 536019016915 Cupin domain; Region: Cupin_2; pfam07883 536019016916 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019016917 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019016918 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019016919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016920 dimer interface [polypeptide binding]; other site 536019016921 conserved gate region; other site 536019016922 putative PBP binding loops; other site 536019016923 ABC-ATPase subunit interface; other site 536019016924 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 536019016925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016926 putative PBP binding loops; other site 536019016927 ABC-ATPase subunit interface; other site 536019016928 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 536019016929 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019016930 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 536019016931 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019016932 putative ligand binding site [chemical binding]; other site 536019016933 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019016934 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019016935 TM-ABC transporter signature motif; other site 536019016936 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019016937 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019016938 Walker A/P-loop; other site 536019016939 ATP binding site [chemical binding]; other site 536019016940 Q-loop/lid; other site 536019016941 ABC transporter signature motif; other site 536019016942 Walker B; other site 536019016943 D-loop; other site 536019016944 H-loop/switch region; other site 536019016945 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019016946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019016947 DNA binding site [nucleotide binding] 536019016948 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 536019016949 putative ligand binding site [chemical binding]; other site 536019016950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019016951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019016952 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019016953 Protein export membrane protein; Region: SecD_SecF; cl14618 536019016954 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019016955 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019016956 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019016957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019016958 DNA-binding site [nucleotide binding]; DNA binding site 536019016959 FCD domain; Region: FCD; pfam07729 536019016960 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019016961 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308 536019016962 metal binding site [ion binding]; metal-binding site 536019016963 substrate binding pocket [chemical binding]; other site 536019016964 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019016965 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019016966 active site pocket [active] 536019016967 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019016968 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019016969 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019016970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016971 dimer interface [polypeptide binding]; other site 536019016972 conserved gate region; other site 536019016973 putative PBP binding loops; other site 536019016974 ABC-ATPase subunit interface; other site 536019016975 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019016976 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536019016977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019016978 putative PBP binding loops; other site 536019016979 dimer interface [polypeptide binding]; other site 536019016980 ABC-ATPase subunit interface; other site 536019016981 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 536019016982 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019016983 Walker A/P-loop; other site 536019016984 ATP binding site [chemical binding]; other site 536019016985 Q-loop/lid; other site 536019016986 ABC transporter signature motif; other site 536019016987 Walker B; other site 536019016988 D-loop; other site 536019016989 H-loop/switch region; other site 536019016990 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019016991 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 536019016992 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019016993 Walker A/P-loop; other site 536019016994 ATP binding site [chemical binding]; other site 536019016995 Q-loop/lid; other site 536019016996 ABC transporter signature motif; other site 536019016997 Walker B; other site 536019016998 D-loop; other site 536019016999 H-loop/switch region; other site 536019017000 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536019017001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019017002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019017003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536019017004 dimerization interface [polypeptide binding]; other site 536019017005 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019017006 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019017007 Domain of unknown function (DUF427); Region: DUF427; pfam04248 536019017008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 536019017009 short chain dehydrogenase; Provisional; Region: PRK06114 536019017010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019017011 NAD(P) binding site [chemical binding]; other site 536019017012 active site 536019017013 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 536019017014 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 536019017015 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 536019017016 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 536019017017 Walker A/P-loop; other site 536019017018 ATP binding site [chemical binding]; other site 536019017019 Q-loop/lid; other site 536019017020 ABC transporter signature motif; other site 536019017021 Walker B; other site 536019017022 D-loop; other site 536019017023 H-loop/switch region; other site 536019017024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017025 dimer interface [polypeptide binding]; other site 536019017026 conserved gate region; other site 536019017027 putative PBP binding loops; other site 536019017028 ABC-ATPase subunit interface; other site 536019017029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017030 dimer interface [polypeptide binding]; other site 536019017031 conserved gate region; other site 536019017032 ABC-ATPase subunit interface; other site 536019017033 Uncharacterized conserved protein [Function unknown]; Region: COG3791 536019017034 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 536019017035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019017036 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 536019017037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019017038 non-specific DNA binding site [nucleotide binding]; other site 536019017039 salt bridge; other site 536019017040 sequence-specific DNA binding site [nucleotide binding]; other site 536019017041 Cupin domain; Region: Cupin_2; pfam07883 536019017042 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 536019017043 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 536019017044 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 536019017045 FMN-binding pocket [chemical binding]; other site 536019017046 flavin binding motif; other site 536019017047 phosphate binding motif [ion binding]; other site 536019017048 beta-alpha-beta structure motif; other site 536019017049 NAD binding pocket [chemical binding]; other site 536019017050 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536019017051 catalytic loop [active] 536019017052 iron binding site [ion binding]; other site 536019017053 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019017054 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019017055 ethanolamine permease; Region: 2A0305; TIGR00908 536019017056 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 536019017057 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 536019017058 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 536019017059 putative active site [active] 536019017060 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 536019017061 domain_subunit interface; other site 536019017062 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 536019017063 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 536019017064 active site 536019017065 FMN binding site [chemical binding]; other site 536019017066 substrate binding site [chemical binding]; other site 536019017067 3Fe-4S cluster binding site [ion binding]; other site 536019017068 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 536019017069 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019017070 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 536019017071 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019017072 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 536019017073 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 536019017074 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 536019017075 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019017076 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 536019017077 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 536019017078 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019017079 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019017080 Amino acid permease; Region: AA_permease_2; pfam13520 536019017081 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 536019017082 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 536019017083 active site 536019017084 non-prolyl cis peptide bond; other site 536019017085 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 536019017086 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 536019017087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019017088 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019017089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019017090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019017091 acyl-CoA synthetase; Validated; Region: PRK08162 536019017092 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 536019017093 acyl-activating enzyme (AAE) consensus motif; other site 536019017094 putative active site [active] 536019017095 AMP binding site [chemical binding]; other site 536019017096 putative CoA binding site [chemical binding]; other site 536019017097 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019017098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019017099 sequence-specific DNA binding site [nucleotide binding]; other site 536019017100 salt bridge; other site 536019017101 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019017102 short chain dehydrogenase; Validated; Region: PRK08324 536019017103 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 536019017104 active site 536019017105 intersubunit interface [polypeptide binding]; other site 536019017106 Zn2+ binding site [ion binding]; other site 536019017107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019017108 NAD(P) binding site [chemical binding]; other site 536019017109 active site 536019017110 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 536019017111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 536019017112 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 536019017113 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019017114 putative ligand binding site [chemical binding]; other site 536019017115 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017116 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017117 TM-ABC transporter signature motif; other site 536019017118 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019017119 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019017120 Walker A/P-loop; other site 536019017121 ATP binding site [chemical binding]; other site 536019017122 Q-loop/lid; other site 536019017123 ABC transporter signature motif; other site 536019017124 Walker B; other site 536019017125 D-loop; other site 536019017126 H-loop/switch region; other site 536019017127 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019017128 Predicted kinase [General function prediction only]; Region: COG4857 536019017129 Phosphotransferase enzyme family; Region: APH; pfam01636 536019017130 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 536019017131 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 536019017132 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536019017133 NADH(P)-binding; Region: NAD_binding_10; pfam13460 536019017134 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 536019017135 transcriptional regulator NanR; Provisional; Region: PRK03837 536019017136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017137 DNA-binding site [nucleotide binding]; DNA binding site 536019017138 FCD domain; Region: FCD; pfam07729 536019017139 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 536019017140 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019017141 putative ligand binding site [chemical binding]; other site 536019017142 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019017143 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019017144 Walker A/P-loop; other site 536019017145 ATP binding site [chemical binding]; other site 536019017146 Q-loop/lid; other site 536019017147 ABC transporter signature motif; other site 536019017148 Walker B; other site 536019017149 D-loop; other site 536019017150 H-loop/switch region; other site 536019017151 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019017152 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017153 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017154 TM-ABC transporter signature motif; other site 536019017155 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017157 TM-ABC transporter signature motif; other site 536019017158 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 536019017159 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 536019017160 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019017161 ligand binding site [chemical binding]; other site 536019017162 dimerization interface [polypeptide binding]; other site 536019017163 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 536019017164 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019017165 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019017166 Walker A/P-loop; other site 536019017167 ATP binding site [chemical binding]; other site 536019017168 Q-loop/lid; other site 536019017169 ABC transporter signature motif; other site 536019017170 Walker B; other site 536019017171 D-loop; other site 536019017172 H-loop/switch region; other site 536019017173 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019017174 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017176 TM-ABC transporter signature motif; other site 536019017177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019017178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019017179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536019017180 transcriptional regulator NanR; Provisional; Region: PRK03837 536019017181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017182 DNA-binding site [nucleotide binding]; DNA binding site 536019017183 FCD domain; Region: FCD; pfam07729 536019017184 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 536019017185 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 536019017186 dimer interface [polypeptide binding]; other site 536019017187 active site 536019017188 catalytic residue [active] 536019017189 metal binding site [ion binding]; metal-binding site 536019017190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 536019017191 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536019017192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019017193 S-adenosylmethionine binding site [chemical binding]; other site 536019017194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536019017195 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019017196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019017197 putative DNA binding site [nucleotide binding]; other site 536019017198 putative Zn2+ binding site [ion binding]; other site 536019017199 AsnC family; Region: AsnC_trans_reg; pfam01037 536019017200 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019017201 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 536019017202 active site 536019017203 homopentamer interface [polypeptide binding]; other site 536019017204 dimer interface [polypeptide binding]; other site 536019017205 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 536019017206 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 536019017207 DAK2 domain; Region: Dak2; cl03685 536019017208 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 536019017209 triosephosphate isomerase; Provisional; Region: PRK14565 536019017210 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 536019017211 substrate binding site [chemical binding]; other site 536019017212 dimer interface [polypeptide binding]; other site 536019017213 catalytic triad [active] 536019017214 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019017215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019017216 putative DNA binding site [nucleotide binding]; other site 536019017217 putative Zn2+ binding site [ion binding]; other site 536019017218 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019017219 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 536019017220 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 536019017221 intersubunit interface [polypeptide binding]; other site 536019017222 active site 536019017223 zinc binding site [ion binding]; other site 536019017224 Na+ binding site [ion binding]; other site 536019017225 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536019017226 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 536019017227 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019017228 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 536019017229 putative ligand binding site [chemical binding]; other site 536019017230 putative NAD binding site [chemical binding]; other site 536019017231 catalytic site [active] 536019017232 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536019017233 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 536019017234 putative N- and C-terminal domain interface [polypeptide binding]; other site 536019017235 putative active site [active] 536019017236 MgATP binding site [chemical binding]; other site 536019017237 catalytic site [active] 536019017238 metal binding site [ion binding]; metal-binding site 536019017239 putative xylulose binding site [chemical binding]; other site 536019017240 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019017241 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 536019017242 Walker A/P-loop; other site 536019017243 ATP binding site [chemical binding]; other site 536019017244 Q-loop/lid; other site 536019017245 ABC transporter signature motif; other site 536019017246 Walker B; other site 536019017247 D-loop; other site 536019017248 H-loop/switch region; other site 536019017249 TOBE domain; Region: TOBE_2; pfam08402 536019017250 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019017251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019017252 Walker A/P-loop; other site 536019017253 ATP binding site [chemical binding]; other site 536019017254 Q-loop/lid; other site 536019017255 ABC transporter signature motif; other site 536019017256 Walker B; other site 536019017257 D-loop; other site 536019017258 H-loop/switch region; other site 536019017259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 536019017260 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019017261 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019017262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017263 dimer interface [polypeptide binding]; other site 536019017264 conserved gate region; other site 536019017265 putative PBP binding loops; other site 536019017266 ABC-ATPase subunit interface; other site 536019017267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019017269 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536019017270 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536019017271 MgtC family; Region: MgtC; pfam02308 536019017272 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 536019017273 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 536019017274 nucleotide binding site [chemical binding]; other site 536019017275 SulA interaction site; other site 536019017276 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019017277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017278 DNA-binding site [nucleotide binding]; DNA binding site 536019017279 FCD domain; Region: FCD; pfam07729 536019017280 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536019017281 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536019017282 aspartate racemase; Region: asp_race; TIGR00035 536019017283 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 536019017284 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536019017285 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 536019017286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019017287 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019017288 substrate binding pocket [chemical binding]; other site 536019017289 membrane-bound complex binding site; other site 536019017290 hinge residues; other site 536019017291 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019017292 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019017293 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019017294 putative active site [active] 536019017295 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 536019017296 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 536019017297 hinge; other site 536019017298 active site 536019017299 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019017300 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536019017301 nucleotide binding site [chemical binding]; other site 536019017302 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 536019017303 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 536019017304 putative active site [active] 536019017305 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 536019017306 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019017307 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019017308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017309 dimer interface [polypeptide binding]; other site 536019017310 conserved gate region; other site 536019017311 putative PBP binding loops; other site 536019017312 ABC-ATPase subunit interface; other site 536019017313 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019017314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017315 putative PBP binding loops; other site 536019017316 dimer interface [polypeptide binding]; other site 536019017317 ABC-ATPase subunit interface; other site 536019017318 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 536019017319 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019017320 Walker A/P-loop; other site 536019017321 ATP binding site [chemical binding]; other site 536019017322 Q-loop/lid; other site 536019017323 ABC transporter signature motif; other site 536019017324 Walker B; other site 536019017325 D-loop; other site 536019017326 H-loop/switch region; other site 536019017327 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019017328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019017329 Walker A/P-loop; other site 536019017330 ATP binding site [chemical binding]; other site 536019017331 Q-loop/lid; other site 536019017332 ABC transporter signature motif; other site 536019017333 Walker B; other site 536019017334 D-loop; other site 536019017335 H-loop/switch region; other site 536019017336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019017337 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019017338 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019017339 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 536019017340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019017341 Coenzyme A binding pocket [chemical binding]; other site 536019017342 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 536019017343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019017344 active site 536019017345 phosphorylation site [posttranslational modification] 536019017346 intermolecular recognition site; other site 536019017347 dimerization interface [polypeptide binding]; other site 536019017348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019017349 Walker A motif; other site 536019017350 ATP binding site [chemical binding]; other site 536019017351 Walker B motif; other site 536019017352 arginine finger; other site 536019017353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019017354 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 536019017355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019017356 dimer interface [polypeptide binding]; other site 536019017357 phosphorylation site [posttranslational modification] 536019017358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019017359 ATP binding site [chemical binding]; other site 536019017360 Mg2+ binding site [ion binding]; other site 536019017361 G-X-G motif; other site 536019017362 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 536019017363 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536019017364 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019017365 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536019017366 nucleotide binding site [chemical binding]; other site 536019017367 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019017368 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 536019017369 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536019017370 substrate binding site [chemical binding]; other site 536019017371 hexamer interface [polypeptide binding]; other site 536019017372 metal binding site [ion binding]; metal-binding site 536019017373 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019017374 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019017375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019017376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019017377 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536019017378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019017379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 536019017380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017381 putative PBP binding loops; other site 536019017382 dimer interface [polypeptide binding]; other site 536019017383 ABC-ATPase subunit interface; other site 536019017384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017385 dimer interface [polypeptide binding]; other site 536019017386 conserved gate region; other site 536019017387 putative PBP binding loops; other site 536019017388 ABC-ATPase subunit interface; other site 536019017389 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017390 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019017391 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536019017392 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019017393 Walker A/P-loop; other site 536019017394 ATP binding site [chemical binding]; other site 536019017395 Q-loop/lid; other site 536019017396 ABC transporter signature motif; other site 536019017397 Walker B; other site 536019017398 D-loop; other site 536019017399 H-loop/switch region; other site 536019017400 TOBE domain; Region: TOBE_2; pfam08402 536019017401 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 536019017402 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019017403 substrate binding site [chemical binding]; other site 536019017404 ATP binding site [chemical binding]; other site 536019017405 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 536019017406 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 536019017407 putative active site; other site 536019017408 catalytic residue [active] 536019017409 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019017410 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536019017411 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019017412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019017413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019017414 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 536019017415 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 536019017416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019017417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019017418 DNA binding site [nucleotide binding] 536019017419 domain linker motif; other site 536019017420 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019017421 dimerization interface [polypeptide binding]; other site 536019017422 ligand binding site [chemical binding]; other site 536019017423 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019017424 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 536019017425 substrate binding site [chemical binding]; other site 536019017426 ATP binding site [chemical binding]; other site 536019017427 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Region: agaZ_gatZ; TIGR02810 536019017428 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 536019017429 putative hydrophobic ligand binding site [chemical binding]; other site 536019017430 protein interface [polypeptide binding]; other site 536019017431 gate; other site 536019017432 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 536019017433 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019017434 NADP binding site [chemical binding]; other site 536019017435 dimer interface [polypeptide binding]; other site 536019017436 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 536019017437 putative hydrophobic ligand binding site [chemical binding]; other site 536019017438 protein interface [polypeptide binding]; other site 536019017439 gate; other site 536019017440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 536019017441 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 536019017442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 536019017443 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019017444 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019017445 Walker A/P-loop; other site 536019017446 ATP binding site [chemical binding]; other site 536019017447 Q-loop/lid; other site 536019017448 ABC transporter signature motif; other site 536019017449 Walker B; other site 536019017450 D-loop; other site 536019017451 H-loop/switch region; other site 536019017452 hypothetical protein; Provisional; Region: PRK02399 536019017453 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 536019017454 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019017455 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019017456 Walker A/P-loop; other site 536019017457 ATP binding site [chemical binding]; other site 536019017458 Q-loop/lid; other site 536019017459 ABC transporter signature motif; other site 536019017460 Walker B; other site 536019017461 D-loop; other site 536019017462 H-loop/switch region; other site 536019017463 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019017464 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 536019017465 putative ligand binding site [chemical binding]; other site 536019017466 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019017467 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019017468 TM-ABC transporter signature motif; other site 536019017469 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019017470 TM-ABC transporter signature motif; other site 536019017471 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 536019017472 Amidohydrolase; Region: Amidohydro_5; pfam13594 536019017473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019017474 active site 536019017475 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 536019017476 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536019017477 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019017478 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536019017479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017480 DNA-binding site [nucleotide binding]; DNA binding site 536019017481 FCD domain; Region: FCD; pfam07729 536019017482 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 536019017483 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019017484 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 536019017485 tetramer interface [polypeptide binding]; other site 536019017486 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 536019017487 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 536019017488 heterodimer interface [polypeptide binding]; other site 536019017489 active site 536019017490 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 536019017491 heterodimer interface [polypeptide binding]; other site 536019017492 multimer interface [polypeptide binding]; other site 536019017493 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 536019017494 active site 536019017495 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 536019017496 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 536019017497 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 536019017498 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 536019017499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019017500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019017501 dimerization interface [polypeptide binding]; other site 536019017502 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536019017503 FAD binding domain; Region: FAD_binding_4; pfam01565 536019017504 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536019017505 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 536019017506 putative ligand binding site [chemical binding]; other site 536019017507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 536019017508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536019017509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536019017510 active site 536019017511 catalytic tetrad [active] 536019017512 TIGR04076 family protein; Region: TIGR04076 536019017513 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 536019017514 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019017515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017516 DNA-binding site [nucleotide binding]; DNA binding site 536019017517 FCD domain; Region: FCD; pfam07729 536019017518 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 536019017519 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019017520 Walker A/P-loop; other site 536019017521 ATP binding site [chemical binding]; other site 536019017522 Q-loop/lid; other site 536019017523 ABC transporter signature motif; other site 536019017524 Walker B; other site 536019017525 D-loop; other site 536019017526 H-loop/switch region; other site 536019017527 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019017528 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019017529 Walker A/P-loop; other site 536019017530 ATP binding site [chemical binding]; other site 536019017531 Q-loop/lid; other site 536019017532 ABC transporter signature motif; other site 536019017533 Walker B; other site 536019017534 D-loop; other site 536019017535 H-loop/switch region; other site 536019017536 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019017537 TM-ABC transporter signature motif; other site 536019017538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017539 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019017540 TM-ABC transporter signature motif; other site 536019017541 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019017542 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019017543 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019017544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017545 DNA-binding site [nucleotide binding]; DNA binding site 536019017546 FCD domain; Region: FCD; pfam07729 536019017547 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 536019017548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019017549 inhibitor-cofactor binding pocket; inhibition site 536019017550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017551 catalytic residue [active] 536019017552 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 536019017553 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 536019017554 active site 536019017555 ATP binding site [chemical binding]; other site 536019017556 substrate binding site [chemical binding]; other site 536019017557 acetylornithine deacetylase; Provisional; Region: PRK06837 536019017558 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 536019017559 metal binding site [ion binding]; metal-binding site 536019017560 dimer interface [polypeptide binding]; other site 536019017561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019017562 Coenzyme A binding pocket [chemical binding]; other site 536019017563 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 536019017564 AAA ATPase domain; Region: AAA_16; pfam13191 536019017565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019017566 DNA binding residues [nucleotide binding] 536019017567 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 536019017568 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 536019017569 active site 536019017570 Zn binding site [ion binding]; other site 536019017571 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536019017572 TM-ABC transporter signature motif; other site 536019017573 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 536019017574 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536019017575 TM-ABC transporter signature motif; other site 536019017576 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 536019017577 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536019017578 Walker A/P-loop; other site 536019017579 ATP binding site [chemical binding]; other site 536019017580 Q-loop/lid; other site 536019017581 ABC transporter signature motif; other site 536019017582 Walker B; other site 536019017583 D-loop; other site 536019017584 H-loop/switch region; other site 536019017585 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 536019017586 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536019017587 Walker A/P-loop; other site 536019017588 ATP binding site [chemical binding]; other site 536019017589 Q-loop/lid; other site 536019017590 ABC transporter signature motif; other site 536019017591 Walker B; other site 536019017592 D-loop; other site 536019017593 H-loop/switch region; other site 536019017594 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 536019017595 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 536019017596 ligand binding site [chemical binding]; other site 536019017597 acetolactate synthase; Reviewed; Region: PRK08322 536019017598 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536019017599 PYR/PP interface [polypeptide binding]; other site 536019017600 dimer interface [polypeptide binding]; other site 536019017601 TPP binding site [chemical binding]; other site 536019017602 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019017603 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 536019017604 TPP-binding site [chemical binding]; other site 536019017605 transcriptional regulator; Provisional; Region: PRK10632 536019017606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019017607 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 536019017608 putative effector binding pocket; other site 536019017609 putative dimerization interface [polypeptide binding]; other site 536019017610 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 536019017611 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019017612 putative NAD(P) binding site [chemical binding]; other site 536019017613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 536019017614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 536019017615 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 536019017616 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 536019017617 active site 2 [active] 536019017618 active site 1 [active] 536019017619 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019017620 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019017621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017622 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019017623 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019017624 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017626 TM-ABC transporter signature motif; other site 536019017627 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019017628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017629 TM-ABC transporter signature motif; other site 536019017630 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 536019017631 Amidohydrolase; Region: Amidohydro_2; pfam04909 536019017632 active site 536019017633 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536019017634 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 536019017635 Bacterial transcriptional regulator; Region: IclR; pfam01614 536019017636 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017637 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019017638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017639 dimer interface [polypeptide binding]; other site 536019017640 conserved gate region; other site 536019017641 putative PBP binding loops; other site 536019017642 ABC-ATPase subunit interface; other site 536019017643 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019017644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017645 dimer interface [polypeptide binding]; other site 536019017646 conserved gate region; other site 536019017647 putative PBP binding loops; other site 536019017648 ABC-ATPase subunit interface; other site 536019017649 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019017650 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019017651 Walker A/P-loop; other site 536019017652 ATP binding site [chemical binding]; other site 536019017653 Q-loop/lid; other site 536019017654 ABC transporter signature motif; other site 536019017655 Walker B; other site 536019017656 D-loop; other site 536019017657 H-loop/switch region; other site 536019017658 TOBE domain; Region: TOBE_2; pfam08402 536019017659 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019017660 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 536019017661 active site pocket [active] 536019017662 Uncharacterized conserved protein [Function unknown]; Region: COG3254 536019017663 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019017664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019017665 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 536019017666 active site 2 [active] 536019017667 active site 1 [active] 536019017668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017669 dimer interface [polypeptide binding]; other site 536019017670 conserved gate region; other site 536019017671 putative PBP binding loops; other site 536019017672 ABC-ATPase subunit interface; other site 536019017673 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 536019017674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017675 dimer interface [polypeptide binding]; other site 536019017676 conserved gate region; other site 536019017677 putative PBP binding loops; other site 536019017678 ABC-ATPase subunit interface; other site 536019017679 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 536019017680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019017681 Walker A/P-loop; other site 536019017682 ATP binding site [chemical binding]; other site 536019017683 Q-loop/lid; other site 536019017684 ABC transporter signature motif; other site 536019017685 Walker B; other site 536019017686 D-loop; other site 536019017687 H-loop/switch region; other site 536019017688 TOBE domain; Region: TOBE_2; pfam08402 536019017689 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536019017690 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536019017691 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 536019017692 ligand binding site [chemical binding]; other site 536019017693 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 536019017694 NAD binding site [chemical binding]; other site 536019017695 dimerization interface [polypeptide binding]; other site 536019017696 catalytic site [active] 536019017697 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 536019017698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019017699 inhibitor-cofactor binding pocket; inhibition site 536019017700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017701 catalytic residue [active] 536019017702 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 536019017703 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 536019017704 NAD(P) binding site [chemical binding]; other site 536019017705 catalytic residues [active] 536019017706 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 536019017707 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 536019017708 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 536019017709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019017710 catalytic residue [active] 536019017711 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 536019017712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019017713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536019017714 dimerization interface [polypeptide binding]; other site 536019017715 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019017716 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019017717 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019017718 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 536019017719 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019017720 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019017721 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536019017722 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019017723 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019017724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017725 DNA-binding site [nucleotide binding]; DNA binding site 536019017726 FCD domain; Region: FCD; pfam07729 536019017727 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019017728 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 536019017729 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 536019017730 putative active site [active] 536019017731 Zn binding site [ion binding]; other site 536019017732 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 536019017733 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019017734 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019017735 active site 536019017736 ectoine utilization protein EutC; Validated; Region: PRK08291 536019017737 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 536019017738 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536019017739 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536019017740 tetramer interface [polypeptide binding]; other site 536019017741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017742 catalytic residue [active] 536019017743 ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990 536019017744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017745 dimer interface [polypeptide binding]; other site 536019017746 conserved gate region; other site 536019017747 putative PBP binding loops; other site 536019017748 ABC-ATPase subunit interface; other site 536019017749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019017750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017751 dimer interface [polypeptide binding]; other site 536019017752 conserved gate region; other site 536019017753 putative PBP binding loops; other site 536019017754 ABC-ATPase subunit interface; other site 536019017755 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 536019017756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019017757 substrate binding pocket [chemical binding]; other site 536019017758 membrane-bound complex binding site; other site 536019017759 hinge residues; other site 536019017760 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 536019017761 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019017762 Walker A/P-loop; other site 536019017763 ATP binding site [chemical binding]; other site 536019017764 Q-loop/lid; other site 536019017765 ABC transporter signature motif; other site 536019017766 Walker B; other site 536019017767 D-loop; other site 536019017768 H-loop/switch region; other site 536019017769 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536019017770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017771 DNA-binding site [nucleotide binding]; DNA binding site 536019017772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019017773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017774 homodimer interface [polypeptide binding]; other site 536019017775 catalytic residue [active] 536019017776 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019017777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019017778 putative DNA binding site [nucleotide binding]; other site 536019017779 putative Zn2+ binding site [ion binding]; other site 536019017780 AsnC family; Region: AsnC_trans_reg; pfam01037 536019017781 succinic semialdehyde dehydrogenase; Region: PLN02278 536019017782 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536019017783 tetramerization interface [polypeptide binding]; other site 536019017784 NAD(P) binding site [chemical binding]; other site 536019017785 catalytic residues [active] 536019017786 hypothetical protein; Provisional; Region: PRK07482 536019017787 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019017788 inhibitor-cofactor binding pocket; inhibition site 536019017789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017790 catalytic residue [active] 536019017791 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 536019017792 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019017793 putative NAD(P) binding site [chemical binding]; other site 536019017794 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 536019017795 active sites [active] 536019017796 tetramer interface [polypeptide binding]; other site 536019017797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019017798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019017799 DNA binding site [nucleotide binding] 536019017800 domain linker motif; other site 536019017801 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019017802 dimerization interface [polypeptide binding]; other site 536019017803 ligand binding site [chemical binding]; other site 536019017804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019017806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017807 dimer interface [polypeptide binding]; other site 536019017808 conserved gate region; other site 536019017809 ABC-ATPase subunit interface; other site 536019017810 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019017811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017812 dimer interface [polypeptide binding]; other site 536019017813 conserved gate region; other site 536019017814 putative PBP binding loops; other site 536019017815 ABC-ATPase subunit interface; other site 536019017816 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 536019017817 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 536019017818 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 536019017819 NAD binding site [chemical binding]; other site 536019017820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019017821 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019017822 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019017823 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019017824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019017825 Walker A/P-loop; other site 536019017826 ATP binding site [chemical binding]; other site 536019017827 Q-loop/lid; other site 536019017828 ABC transporter signature motif; other site 536019017829 Walker B; other site 536019017830 D-loop; other site 536019017831 H-loop/switch region; other site 536019017832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019017833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019017834 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 536019017835 Walker A/P-loop; other site 536019017836 ATP binding site [chemical binding]; other site 536019017837 Q-loop/lid; other site 536019017838 ABC transporter signature motif; other site 536019017839 Walker B; other site 536019017840 D-loop; other site 536019017841 H-loop/switch region; other site 536019017842 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019017843 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019017844 Walker A/P-loop; other site 536019017845 ATP binding site [chemical binding]; other site 536019017846 Q-loop/lid; other site 536019017847 ABC transporter signature motif; other site 536019017848 Walker B; other site 536019017849 D-loop; other site 536019017850 H-loop/switch region; other site 536019017851 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019017852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017853 dimer interface [polypeptide binding]; other site 536019017854 conserved gate region; other site 536019017855 putative PBP binding loops; other site 536019017856 ABC-ATPase subunit interface; other site 536019017857 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 536019017858 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 536019017859 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 536019017860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017861 DNA-binding site [nucleotide binding]; DNA binding site 536019017862 UTRA domain; Region: UTRA; pfam07702 536019017863 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536019017864 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019017865 NAD(P) binding site [chemical binding]; other site 536019017866 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 536019017867 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 536019017868 NAD binding site [chemical binding]; other site 536019017869 dimerization interface [polypeptide binding]; other site 536019017870 product binding site; other site 536019017871 substrate binding site [chemical binding]; other site 536019017872 zinc binding site [ion binding]; other site 536019017873 catalytic residues [active] 536019017874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019017875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019017876 NAD(P) binding site [chemical binding]; other site 536019017877 active site 536019017878 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 536019017879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019017880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019017881 homodimer interface [polypeptide binding]; other site 536019017882 catalytic residue [active] 536019017883 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536019017884 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019017885 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019017886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019017887 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536019017888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017889 dimer interface [polypeptide binding]; other site 536019017890 putative PBP binding loops; other site 536019017891 ABC-ATPase subunit interface; other site 536019017892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019017893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017894 dimer interface [polypeptide binding]; other site 536019017895 conserved gate region; other site 536019017896 putative PBP binding loops; other site 536019017897 ABC-ATPase subunit interface; other site 536019017898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536019017899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536019017900 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019017901 classical (c) SDRs; Region: SDR_c; cd05233 536019017902 NAD(P) binding site [chemical binding]; other site 536019017903 active site 536019017904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019017905 extended (e) SDRs; Region: SDR_e; cd08946 536019017906 NAD(P) binding site [chemical binding]; other site 536019017907 active site 536019017908 substrate binding site [chemical binding]; other site 536019017909 Isochorismatase family; Region: Isochorismatase; pfam00857 536019017910 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536019017911 catalytic triad [active] 536019017912 conserved cis-peptide bond; other site 536019017913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019017914 MarR family; Region: MarR_2; pfam12802 536019017915 Amidohydrolase; Region: Amidohydro_5; pfam13594 536019017916 Amidohydrolase; Region: Amidohydro_4; pfam13147 536019017917 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 536019017918 active site 536019017919 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536019017920 Amino acid synthesis; Region: AA_synth; pfam06684 536019017921 Amino acid synthesis; Region: AA_synth; pfam06684 536019017922 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 536019017923 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 536019017924 ligand binding site [chemical binding]; other site 536019017925 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 536019017926 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019017927 Walker A/P-loop; other site 536019017928 ATP binding site [chemical binding]; other site 536019017929 Q-loop/lid; other site 536019017930 ABC transporter signature motif; other site 536019017931 Walker B; other site 536019017932 D-loop; other site 536019017933 H-loop/switch region; other site 536019017934 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019017935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017936 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019017937 TM-ABC transporter signature motif; other site 536019017938 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019017939 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 536019017940 TM-ABC transporter signature motif; other site 536019017941 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 536019017942 active site 536019017943 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536019017944 active site 536019017945 tetramer interface [polypeptide binding]; other site 536019017946 S-formylglutathione hydrolase; Region: PLN02442 536019017947 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 536019017948 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019017949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019017950 DNA-binding site [nucleotide binding]; DNA binding site 536019017951 FCD domain; Region: FCD; pfam07729 536019017952 Amino acid synthesis; Region: AA_synth; pfam06684 536019017953 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 536019017954 PGAP1-like protein; Region: PGAP1; pfam07819 536019017955 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 536019017956 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 536019017957 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536019017958 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019017959 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 536019017960 NAD(P) binding site [chemical binding]; other site 536019017961 catalytic residues [active] 536019017962 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 536019017963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536019017964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017965 dimer interface [polypeptide binding]; other site 536019017966 putative PBP binding loops; other site 536019017967 ABC-ATPase subunit interface; other site 536019017968 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536019017969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019017970 dimer interface [polypeptide binding]; other site 536019017971 conserved gate region; other site 536019017972 putative PBP binding loops; other site 536019017973 ABC-ATPase subunit interface; other site 536019017974 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536019017975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536019017976 Walker A/P-loop; other site 536019017977 ATP binding site [chemical binding]; other site 536019017978 Q-loop/lid; other site 536019017979 ABC transporter signature motif; other site 536019017980 Walker B; other site 536019017981 D-loop; other site 536019017982 H-loop/switch region; other site 536019017983 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 536019017984 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 536019017985 FMN binding site [chemical binding]; other site 536019017986 active site 536019017987 homodimer interface [polypeptide binding]; other site 536019017988 putative catalytic residue [active] 536019017989 4Fe-4S cluster binding site [ion binding]; other site 536019017990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019017991 acetylornithine deacetylase; Provisional; Region: PRK07522 536019017992 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 536019017993 metal binding site [ion binding]; metal-binding site 536019017994 putative dimer interface [polypeptide binding]; other site 536019017995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019017996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019017997 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 536019017998 putative substrate binding pocket [chemical binding]; other site 536019017999 dimerization interface [polypeptide binding]; other site 536019018000 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019018001 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 536019018002 NAD(P) binding site [chemical binding]; other site 536019018003 catalytic residues [active] 536019018004 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 536019018005 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536019018006 homotrimer interaction site [polypeptide binding]; other site 536019018007 putative active site [active] 536019018008 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 536019018009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019018010 choline dehydrogenase; Validated; Region: PRK02106 536019018011 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 536019018012 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536019018013 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536019018014 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 536019018015 Walker A/P-loop; other site 536019018016 ATP binding site [chemical binding]; other site 536019018017 Q-loop/lid; other site 536019018018 ABC transporter signature motif; other site 536019018019 Walker B; other site 536019018020 D-loop; other site 536019018021 H-loop/switch region; other site 536019018022 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536019018023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018024 dimer interface [polypeptide binding]; other site 536019018025 conserved gate region; other site 536019018026 putative PBP binding loops; other site 536019018027 ABC-ATPase subunit interface; other site 536019018028 NMT1/THI5 like; Region: NMT1; pfam09084 536019018029 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 536019018030 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536019018031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019018032 putative substrate translocation pore; other site 536019018033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019018034 MarR family; Region: MarR_2; pfam12802 536019018035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536019018036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019018037 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019018038 TM-ABC transporter signature motif; other site 536019018039 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019018040 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019018041 Walker A/P-loop; other site 536019018042 ATP binding site [chemical binding]; other site 536019018043 Q-loop/lid; other site 536019018044 ABC transporter signature motif; other site 536019018045 Walker B; other site 536019018046 D-loop; other site 536019018047 H-loop/switch region; other site 536019018048 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019018049 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536019018050 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536019018051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536019018052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019018053 DNA binding site [nucleotide binding] 536019018054 domain linker motif; other site 536019018055 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 536019018056 dimerization interface [polypeptide binding]; other site 536019018057 ligand binding site [chemical binding]; other site 536019018058 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 536019018059 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536019018060 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536019018061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536019018062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536019018063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018064 dimer interface [polypeptide binding]; other site 536019018065 conserved gate region; other site 536019018066 putative PBP binding loops; other site 536019018067 ABC-ATPase subunit interface; other site 536019018068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536019018069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018070 dimer interface [polypeptide binding]; other site 536019018071 conserved gate region; other site 536019018072 putative PBP binding loops; other site 536019018073 ABC-ATPase subunit interface; other site 536019018074 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536019018075 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536019018076 Walker A/P-loop; other site 536019018077 ATP binding site [chemical binding]; other site 536019018078 Q-loop/lid; other site 536019018079 ABC transporter signature motif; other site 536019018080 Walker B; other site 536019018081 D-loop; other site 536019018082 H-loop/switch region; other site 536019018083 TOBE domain; Region: TOBE_2; pfam08402 536019018084 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 536019018085 classical (c) SDRs; Region: SDR_c; cd05233 536019018086 NAD(P) binding site [chemical binding]; other site 536019018087 active site 536019018088 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536019018089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536019018090 classical (c) SDRs; Region: SDR_c; cd05233 536019018091 NAD(P) binding site [chemical binding]; other site 536019018092 active site 536019018093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019018094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019018095 LysR substrate binding domain; Region: LysR_substrate; pfam03466 536019018096 dimerization interface [polypeptide binding]; other site 536019018097 short chain dehydrogenase; Provisional; Region: PRK06500 536019018098 classical (c) SDRs; Region: SDR_c; cd05233 536019018099 NAD(P) binding site [chemical binding]; other site 536019018100 active site 536019018101 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 536019018102 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 536019018103 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 536019018104 putative hydrophobic ligand binding site [chemical binding]; other site 536019018105 short chain dehydrogenase; Provisional; Region: PRK06523 536019018106 classical (c) SDRs; Region: SDR_c; cd05233 536019018107 NAD(P) binding site [chemical binding]; other site 536019018108 active site 536019018109 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 536019018110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019018111 NAD(P) binding site [chemical binding]; other site 536019018112 catalytic residues [active] 536019018113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019018114 Protein of unknown function (DUF541); Region: SIMPL; cl01077 536019018115 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 536019018116 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 536019018117 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536019018118 HlyD family secretion protein; Region: HlyD_3; pfam13437 536019018119 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 536019018120 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019018121 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 536019018122 Walker A/P-loop; other site 536019018123 ATP binding site [chemical binding]; other site 536019018124 Q-loop/lid; other site 536019018125 ABC transporter signature motif; other site 536019018126 Walker B; other site 536019018127 D-loop; other site 536019018128 H-loop/switch region; other site 536019018129 VCBS repeat; Region: VCBS_repeat; TIGR01965 536019018130 VCBS repeat; Region: VCBS_repeat; TIGR01965 536019018131 VCBS repeat; Region: VCBS_repeat; TIGR01965 536019018132 VCBS repeat; Region: VCBS_repeat; TIGR01965 536019018133 VCBS repeat; Region: VCBS_repeat; TIGR01965 536019018134 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 536019018135 GAF domain; Region: GAF; pfam01590 536019018136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019018137 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 536019018138 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019018139 NAD(P) binding site [chemical binding]; other site 536019018140 catalytic residues [active] 536019018141 Protein of unknown function (DUF779); Region: DUF779; cl01432 536019018142 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 536019018143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019018144 FeS/SAM binding site; other site 536019018145 HemN C-terminal domain; Region: HemN_C; pfam06969 536019018146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019018147 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019018148 ligand binding site [chemical binding]; other site 536019018149 flexible hinge region; other site 536019018150 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019018151 putative switch regulator; other site 536019018152 non-specific DNA interactions [nucleotide binding]; other site 536019018153 DNA binding site [nucleotide binding] 536019018154 sequence specific DNA binding site [nucleotide binding]; other site 536019018155 putative cAMP binding site [chemical binding]; other site 536019018156 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 536019018157 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 536019018158 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 536019018159 Low-spin heme binding site [chemical binding]; other site 536019018160 Putative water exit pathway; other site 536019018161 Binuclear center (active site) [active] 536019018162 Putative proton exit pathway; other site 536019018163 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 536019018164 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 536019018165 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 536019018166 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 536019018167 Cytochrome c; Region: Cytochrom_C; pfam00034 536019018168 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 536019018169 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 536019018170 4Fe-4S binding domain; Region: Fer4_5; pfam12801 536019018171 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 536019018172 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 536019018173 FixH; Region: FixH; pfam05751 536019018174 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 536019018175 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 536019018176 metal-binding site [ion binding] 536019018177 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536019018178 Soluble P-type ATPase [General function prediction only]; Region: COG4087 536019018179 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 536019018180 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 536019018181 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 536019018182 Multicopper oxidase; Region: Cu-oxidase; pfam00394 536019018183 Uncharacterized conserved protein [Function unknown]; Region: COG1262 536019018184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 536019018185 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 536019018186 NnrS protein; Region: NnrS; pfam05940 536019018187 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 536019018188 pseudoazurin; Region: pseudoazurin; TIGR02375 536019018189 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019018190 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019018191 ligand binding site [chemical binding]; other site 536019018192 flexible hinge region; other site 536019018193 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019018194 putative switch regulator; other site 536019018195 non-specific DNA interactions [nucleotide binding]; other site 536019018196 DNA binding site [nucleotide binding] 536019018197 sequence specific DNA binding site [nucleotide binding]; other site 536019018198 putative cAMP binding site [chemical binding]; other site 536019018199 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 536019018200 FOG: CBS domain [General function prediction only]; Region: COG0517 536019018201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 536019018202 BON domain; Region: BON; pfam04972 536019018203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019018204 Ligand Binding Site [chemical binding]; other site 536019018205 PAS fold; Region: PAS_4; pfam08448 536019018206 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 536019018207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536019018208 putative active site [active] 536019018209 heme pocket [chemical binding]; other site 536019018210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019018211 dimer interface [polypeptide binding]; other site 536019018212 phosphorylation site [posttranslational modification] 536019018213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019018214 ATP binding site [chemical binding]; other site 536019018215 Mg2+ binding site [ion binding]; other site 536019018216 G-X-G motif; other site 536019018217 response regulator FixJ; Provisional; Region: fixJ; PRK09390 536019018218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019018219 active site 536019018220 phosphorylation site [posttranslational modification] 536019018221 intermolecular recognition site; other site 536019018222 dimerization interface [polypeptide binding]; other site 536019018223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019018224 DNA binding residues [nucleotide binding] 536019018225 dimerization interface [polypeptide binding]; other site 536019018226 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 536019018227 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 536019018228 substrate-cofactor binding pocket; other site 536019018229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018230 catalytic residue [active] 536019018231 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 536019018232 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 536019018233 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019018234 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019018235 ligand binding site [chemical binding]; other site 536019018236 flexible hinge region; other site 536019018237 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019018238 putative switch regulator; other site 536019018239 non-specific DNA interactions [nucleotide binding]; other site 536019018240 DNA binding site [nucleotide binding] 536019018241 sequence specific DNA binding site [nucleotide binding]; other site 536019018242 putative cAMP binding site [chemical binding]; other site 536019018243 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 536019018244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019018245 TPR motif; other site 536019018246 binding surface 536019018247 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536019018248 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536019018249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 536019018250 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536019018251 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 536019018252 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019018253 substrate binding site [chemical binding]; other site 536019018254 oxyanion hole (OAH) forming residues; other site 536019018255 trimer interface [polypeptide binding]; other site 536019018256 SnoaL-like domain; Region: SnoaL_3; pfam13474 536019018257 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 536019018258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019018259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536019018260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536019018261 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 536019018262 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 536019018263 Phosphopantetheine attachment site; Region: PP-binding; cl09936 536019018264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019018265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019018266 non-specific DNA binding site [nucleotide binding]; other site 536019018267 salt bridge; other site 536019018268 sequence-specific DNA binding site [nucleotide binding]; other site 536019018269 Domain of unknown function (DUF955); Region: DUF955; pfam06114 536019018270 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 536019018271 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 536019018272 active site 536019018273 thymidylate synthase; Provisional; Region: thyA; PRK00956 536019018274 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 536019018275 trimer interface [polypeptide binding]; other site 536019018276 active site 536019018277 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 536019018278 putative metal binding site [ion binding]; other site 536019018279 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 536019018280 putative uracil binding site [chemical binding]; other site 536019018281 putative active site [active] 536019018282 hypothetical protein; Provisional; Region: PRK09126 536019018283 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019018284 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 536019018285 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 536019018286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 536019018287 metal-binding site [ion binding] 536019018288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536019018289 Soluble P-type ATPase [General function prediction only]; Region: COG4087 536019018290 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 536019018291 FixH; Region: FixH; pfam05751 536019018292 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 536019018293 4Fe-4S binding domain; Region: Fer4_5; pfam12801 536019018294 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 536019018295 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 536019018296 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 536019018297 Cytochrome c; Region: Cytochrom_C; pfam00034 536019018298 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 536019018299 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 536019018300 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 536019018301 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 536019018302 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 536019018303 Low-spin heme binding site [chemical binding]; other site 536019018304 Putative water exit pathway; other site 536019018305 Binuclear center (active site) [active] 536019018306 Putative proton exit pathway; other site 536019018307 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019018308 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536019018309 ligand binding site [chemical binding]; other site 536019018310 flexible hinge region; other site 536019018311 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536019018312 putative switch regulator; other site 536019018313 non-specific DNA interactions [nucleotide binding]; other site 536019018314 DNA binding site [nucleotide binding] 536019018315 sequence specific DNA binding site [nucleotide binding]; other site 536019018316 putative cAMP binding site [chemical binding]; other site 536019018317 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 536019018318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019018319 FeS/SAM binding site; other site 536019018320 HemN C-terminal domain; Region: HemN_C; pfam06969 536019018321 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 536019018322 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 536019018323 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 536019018324 VirB7 interaction site; other site 536019018325 conjugal transfer protein TrbF; Provisional; Region: PRK13872 536019018326 conjugal transfer protein TrbL; Provisional; Region: PRK13875 536019018327 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 536019018328 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 536019018329 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 536019018330 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 536019018331 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 536019018332 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 536019018333 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 536019018334 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 536019018335 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 536019018336 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019018337 ATP binding site [chemical binding]; other site 536019018338 Walker A motif; other site 536019018339 hexamer interface [polypeptide binding]; other site 536019018340 Walker B motif; other site 536019018341 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 536019018342 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 536019018343 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 536019018344 Walker A motif; other site 536019018345 ATP binding site [chemical binding]; other site 536019018346 Walker B motif; other site 536019018347 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 536019018348 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 536019018349 glutaminase active site [active] 536019018350 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 536019018351 dimer interface [polypeptide binding]; other site 536019018352 active site 536019018353 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536019018354 dimer interface [polypeptide binding]; other site 536019018355 active site 536019018356 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 536019018357 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 536019018358 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536019018359 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019018360 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019018361 catalytic residue [active] 536019018362 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 536019018363 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 536019018364 Helix-turn-helix domain; Region: HTH_17; pfam12728 536019018365 Uncharacterized conserved protein [Function unknown]; Region: COG5489 536019018366 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 536019018367 ParB-like nuclease domain; Region: ParB; smart00470 536019018368 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 536019018369 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 536019018370 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 536019018371 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 536019018372 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 536019018373 catalytic residues [active] 536019018374 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 536019018375 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019018376 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 536019018377 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 536019018378 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 536019018379 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 536019018380 active site 536019018381 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 536019018382 Ligand Binding Site [chemical binding]; other site 536019018383 Helix-turn-helix; Region: HTH_3; pfam01381 536019018384 non-specific DNA binding site [nucleotide binding]; other site 536019018385 salt bridge; other site 536019018386 sequence-specific DNA binding site [nucleotide binding]; other site 536019018387 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 536019018388 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 536019018389 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 536019018390 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 536019018391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019018392 active site 536019018393 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 536019018394 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 536019018395 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019018396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019018397 DNA binding residues [nucleotide binding] 536019018398 dimerization interface [polypeptide binding]; other site 536019018399 Pantoate-beta-alanine ligase; Region: PanC; cd00560 536019018400 pantoate--beta-alanine ligase; Region: panC; TIGR00018 536019018401 active site 536019018402 ATP-binding site [chemical binding]; other site 536019018403 pantoate-binding site; other site 536019018404 HXXH motif; other site 536019018405 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 536019018406 oligomerization interface [polypeptide binding]; other site 536019018407 active site 536019018408 metal binding site [ion binding]; metal-binding site 536019018409 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 536019018410 quinolinate synthetase; Provisional; Region: PRK09375 536019018411 L-aspartate oxidase; Provisional; Region: PRK07512 536019018412 L-aspartate oxidase; Provisional; Region: PRK06175 536019018413 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 536019018414 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 536019018415 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 536019018416 dimerization interface [polypeptide binding]; other site 536019018417 active site 536019018418 biotin synthase; Region: bioB; TIGR00433 536019018419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019018420 FeS/SAM binding site; other site 536019018421 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 536019018422 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 536019018423 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 536019018424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019018425 catalytic residue [active] 536019018426 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 536019018427 AAA domain; Region: AAA_26; pfam13500 536019018428 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 536019018429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019018430 inhibitor-cofactor binding pocket; inhibition site 536019018431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018432 catalytic residue [active] 536019018433 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 536019018434 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 536019018435 dimer interface [polypeptide binding]; other site 536019018436 active site 536019018437 CoA binding pocket [chemical binding]; other site 536019018438 Transmembrane secretion effector; Region: MFS_3; pfam05977 536019018439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019018440 HipA N-terminal domain; Region: Couple_hipA; cl11853 536019018441 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536019018442 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536019018443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019018444 non-specific DNA binding site [nucleotide binding]; other site 536019018445 salt bridge; other site 536019018446 sequence-specific DNA binding site [nucleotide binding]; other site 536019018447 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 536019018448 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 536019018449 active site 536019018450 zinc binding site [ion binding]; other site 536019018451 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 536019018452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019018453 dimer interface [polypeptide binding]; other site 536019018454 phosphorylation site [posttranslational modification] 536019018455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019018456 ATP binding site [chemical binding]; other site 536019018457 Mg2+ binding site [ion binding]; other site 536019018458 G-X-G motif; other site 536019018459 type IV secretion system protein VirB11; Provisional; Region: PRK13851 536019018460 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019018461 Walker A motif; other site 536019018462 hexamer interface [polypeptide binding]; other site 536019018463 ATP binding site [chemical binding]; other site 536019018464 Walker B motif; other site 536019018465 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 536019018466 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 536019018467 VirB7 interaction site; other site 536019018468 type IV secretion system protein VirB8; Provisional; Region: PRK13865 536019018469 type IV secretion system lipoprotein VirB7; Provisional; Region: PRK13859 536019018470 type IV secretion system protein VirB6; Provisional; Region: PRK13852 536019018471 type IV secretion system protein VirB5; Provisional; Region: PRK13860 536019018472 type IV secretion system protein VirB4; Provisional; Region: PRK13853 536019018473 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 536019018474 type IV secretion system protein VirB3; Provisional; Region: PRK13854 536019018475 TrbC/VIRB2 family; Region: TrbC; cl01583 536019018476 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536019018477 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536019018478 catalytic residue [active] 536019018479 two-component response regulator VirG; Provisional; Region: PRK13856 536019018480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019018481 active site 536019018482 phosphorylation site [posttranslational modification] 536019018483 intermolecular recognition site; other site 536019018484 dimerization interface [polypeptide binding]; other site 536019018485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019018486 DNA binding site [nucleotide binding] 536019018487 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 536019018488 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 536019018489 Walker A motif; other site 536019018490 ATP binding site [chemical binding]; other site 536019018491 Walker B motif; other site 536019018492 RNA silencing suppressor P21; Region: Suppressor_P21; pfam11479 536019018493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019018494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019018495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019018496 dimerization interface [polypeptide binding]; other site 536019018497 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 536019018498 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 536019018499 putative active site [active] 536019018500 putative metal binding site [ion binding]; other site 536019018501 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 536019018502 amidohydrolase; Region: amidohydrolases; TIGR01891 536019018503 putative metal binding site [ion binding]; other site 536019018504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 536019018505 alanine racemase; Reviewed; Region: alr; PRK00053 536019018506 active site 536019018507 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536019018508 dimer interface [polypeptide binding]; other site 536019018509 substrate binding site [chemical binding]; other site 536019018510 catalytic residues [active] 536019018511 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 536019018512 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019018513 Walker A/P-loop; other site 536019018514 ATP binding site [chemical binding]; other site 536019018515 Q-loop/lid; other site 536019018516 ABC transporter signature motif; other site 536019018517 Walker B; other site 536019018518 D-loop; other site 536019018519 H-loop/switch region; other site 536019018520 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 536019018521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019018522 substrate binding pocket [chemical binding]; other site 536019018523 membrane-bound complex binding site; other site 536019018524 hinge residues; other site 536019018525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019018526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018527 dimer interface [polypeptide binding]; other site 536019018528 conserved gate region; other site 536019018529 putative PBP binding loops; other site 536019018530 ABC-ATPase subunit interface; other site 536019018531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018532 dimer interface [polypeptide binding]; other site 536019018533 conserved gate region; other site 536019018534 putative PBP binding loops; other site 536019018535 ABC-ATPase subunit interface; other site 536019018536 Arginase family; Region: Arginase; cd09989 536019018537 active site 536019018538 Mn binding site [ion binding]; other site 536019018539 oligomer interface [polypeptide binding]; other site 536019018540 ornithine cyclodeaminase; Validated; Region: PRK07589 536019018541 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 536019018542 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 536019018543 Amidinotransferase; Region: Amidinotransf; pfam02274 536019018544 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 536019018545 Amidinotransferase; Region: Amidinotransf; cl12043 536019018546 Predicted methyltransferase [General function prediction only]; Region: COG3897 536019018547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019018548 S-adenosylmethionine binding site [chemical binding]; other site 536019018549 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019018550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019018551 S-adenosylmethionine binding site [chemical binding]; other site 536019018552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 536019018553 non-specific DNA binding site [nucleotide binding]; other site 536019018554 salt bridge; other site 536019018555 sequence-specific DNA binding site [nucleotide binding]; other site 536019018556 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536019018557 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536019018558 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 536019018559 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 536019018560 dimer interface [polypeptide binding]; other site 536019018561 active site 536019018562 glycine-pyridoxal phosphate binding site [chemical binding]; other site 536019018563 folate binding site [chemical binding]; other site 536019018564 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 536019018565 S-adenosylmethionine synthetase; Validated; Region: PRK05250 536019018566 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 536019018567 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 536019018568 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 536019018569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019018570 substrate binding site [chemical binding]; other site 536019018571 ATP binding site [chemical binding]; other site 536019018572 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 536019018573 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536019018574 NAD(P) binding site [chemical binding]; other site 536019018575 Predicted transcriptional regulator [Transcription]; Region: COG4957 536019018576 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 536019018577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019018578 FeS/SAM binding site; other site 536019018579 HemN C-terminal domain; Region: HemN_C; pfam06969 536019018580 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536019018581 DNA-binding site [nucleotide binding]; DNA binding site 536019018582 RNA-binding motif; other site 536019018583 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 536019018584 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019018585 Cytochrome P450; Region: p450; cl12078 536019018586 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 536019018587 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 536019018588 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019018589 Cytochrome P450; Region: p450; cl12078 536019018590 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 536019018591 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 536019018592 substrate binding pocket [chemical binding]; other site 536019018593 chain length determination region; other site 536019018594 substrate-Mg2+ binding site; other site 536019018595 catalytic residues [active] 536019018596 aspartate-rich region 1; other site 536019018597 active site lid residues [active] 536019018598 aspartate-rich region 2; other site 536019018599 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 536019018600 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 536019018601 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 536019018602 substrate binding pocket [chemical binding]; other site 536019018603 substrate-Mg2+ binding site; other site 536019018604 aspartate-rich region 1; other site 536019018605 aspartate-rich region 2; other site 536019018606 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 536019018607 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 536019018608 homotetramer interface [polypeptide binding]; other site 536019018609 FMN binding site [chemical binding]; other site 536019018610 homodimer contacts [polypeptide binding]; other site 536019018611 putative active site [active] 536019018612 putative substrate binding site [chemical binding]; other site 536019018613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019018614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019018615 active site 536019018616 phosphorylation site [posttranslational modification] 536019018617 intermolecular recognition site; other site 536019018618 dimerization interface [polypeptide binding]; other site 536019018619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019018620 DNA binding site [nucleotide binding] 536019018621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019018622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019018623 ATP binding site [chemical binding]; other site 536019018624 Mg2+ binding site [ion binding]; other site 536019018625 G-X-G motif; other site 536019018626 HipA N-terminal domain; Region: Couple_hipA; cl11853 536019018627 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536019018628 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536019018629 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536019018630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019018631 non-specific DNA binding site [nucleotide binding]; other site 536019018632 salt bridge; other site 536019018633 sequence-specific DNA binding site [nucleotide binding]; other site 536019018634 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 536019018635 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536019018636 succinic semialdehyde dehydrogenase; Region: PLN02278 536019018637 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536019018638 tetramerization interface [polypeptide binding]; other site 536019018639 NAD(P) binding site [chemical binding]; other site 536019018640 catalytic residues [active] 536019018641 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 536019018642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019018643 active site 536019018644 motif I; other site 536019018645 motif II; other site 536019018646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536019018647 Uncharacterized conserved protein [Function unknown]; Region: COG5419 536019018648 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 536019018649 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019018650 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 536019018651 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536019018652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019018653 non-specific DNA binding site [nucleotide binding]; other site 536019018654 salt bridge; other site 536019018655 sequence-specific DNA binding site [nucleotide binding]; other site 536019018656 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019018657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019018658 DNA binding residues [nucleotide binding] 536019018659 dimerization interface [polypeptide binding]; other site 536019018660 hypothetical protein; Provisional; Region: PRK07482 536019018661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019018662 inhibitor-cofactor binding pocket; inhibition site 536019018663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018664 catalytic residue [active] 536019018665 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 536019018666 ATP binding site [chemical binding]; other site 536019018667 substrate interface [chemical binding]; other site 536019018668 ThiF family; Region: ThiF; pfam00899 536019018669 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536019018670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536019018671 putative DNA binding site [nucleotide binding]; other site 536019018672 putative Zn2+ binding site [ion binding]; other site 536019018673 AsnC family; Region: AsnC_trans_reg; pfam01037 536019018674 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 536019018675 Fumarase C-terminus; Region: Fumerase_C; pfam05683 536019018676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019018677 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536019018678 tetramerization interface [polypeptide binding]; other site 536019018679 NAD(P) binding site [chemical binding]; other site 536019018680 catalytic residues [active] 536019018681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019018682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019018683 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 536019018684 putative dimerization interface [polypeptide binding]; other site 536019018685 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 536019018686 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 536019018687 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536019018688 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 536019018689 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 536019018690 dimer interface [polypeptide binding]; other site 536019018691 active site 536019018692 Homeodomain-like domain; Region: HTH_23; cl17451 536019018693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019018694 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019018695 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019018696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536019018697 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 536019018698 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 536019018699 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 536019018700 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 536019018701 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 536019018702 putative active site [active] 536019018703 putative metal binding site [ion binding]; other site 536019018704 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 536019018705 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 536019018706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019018707 Walker A/P-loop; other site 536019018708 ATP binding site [chemical binding]; other site 536019018709 Q-loop/lid; other site 536019018710 ABC transporter signature motif; other site 536019018711 Walker B; other site 536019018712 D-loop; other site 536019018713 H-loop/switch region; other site 536019018714 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536019018715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 536019018716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019018717 Walker A/P-loop; other site 536019018718 ATP binding site [chemical binding]; other site 536019018719 Q-loop/lid; other site 536019018720 ABC transporter signature motif; other site 536019018721 Walker B; other site 536019018722 D-loop; other site 536019018723 H-loop/switch region; other site 536019018724 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536019018725 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 536019018726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018727 putative PBP binding loops; other site 536019018728 dimer interface [polypeptide binding]; other site 536019018729 ABC-ATPase subunit interface; other site 536019018730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019018731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018732 dimer interface [polypeptide binding]; other site 536019018733 conserved gate region; other site 536019018734 putative PBP binding loops; other site 536019018735 ABC-ATPase subunit interface; other site 536019018736 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019018737 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 536019018738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536019018739 Beta-lactamase; Region: Beta-lactamase; pfam00144 536019018740 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019018741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019018742 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019018743 Predicted deacylase [General function prediction only]; Region: COG3608 536019018744 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 536019018745 active site 536019018746 Zn binding site [ion binding]; other site 536019018747 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 536019018748 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536019018749 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 536019018750 active site 536019018751 hypothetical protein; Provisional; Region: PRK07475 536019018752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019018753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019018754 substrate binding pocket [chemical binding]; other site 536019018755 membrane-bound complex binding site; other site 536019018756 hinge residues; other site 536019018757 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019018758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018759 dimer interface [polypeptide binding]; other site 536019018760 conserved gate region; other site 536019018761 putative PBP binding loops; other site 536019018762 ABC-ATPase subunit interface; other site 536019018763 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019018764 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019018765 Walker A/P-loop; other site 536019018766 ATP binding site [chemical binding]; other site 536019018767 Q-loop/lid; other site 536019018768 ABC transporter signature motif; other site 536019018769 Walker B; other site 536019018770 D-loop; other site 536019018771 H-loop/switch region; other site 536019018772 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 536019018773 putative active site [active] 536019018774 Zn binding site [ion binding]; other site 536019018775 Predicted acyl esterases [General function prediction only]; Region: COG2936 536019018776 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 536019018777 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 536019018778 Amidase; Region: Amidase; cl11426 536019018779 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019018780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 536019018781 Walker A/P-loop; other site 536019018782 ATP binding site [chemical binding]; other site 536019018783 Q-loop/lid; other site 536019018784 ABC transporter signature motif; other site 536019018785 Walker B; other site 536019018786 D-loop; other site 536019018787 H-loop/switch region; other site 536019018788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536019018789 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 536019018790 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536019018791 Walker A/P-loop; other site 536019018792 ATP binding site [chemical binding]; other site 536019018793 Q-loop/lid; other site 536019018794 ABC transporter signature motif; other site 536019018795 Walker B; other site 536019018796 D-loop; other site 536019018797 H-loop/switch region; other site 536019018798 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536019018799 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 536019018800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 536019018801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018802 putative PBP binding loops; other site 536019018803 dimer interface [polypeptide binding]; other site 536019018804 ABC-ATPase subunit interface; other site 536019018805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536019018806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018807 dimer interface [polypeptide binding]; other site 536019018808 conserved gate region; other site 536019018809 putative PBP binding loops; other site 536019018810 ABC-ATPase subunit interface; other site 536019018811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536019018812 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 536019018813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019018814 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 536019018815 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 536019018816 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019018817 inhibitor-cofactor binding pocket; inhibition site 536019018818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018819 catalytic residue [active] 536019018820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536019018821 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019018822 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 536019018823 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536019018824 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536019018825 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536019018826 Walker A/P-loop; other site 536019018827 ATP binding site [chemical binding]; other site 536019018828 Q-loop/lid; other site 536019018829 ABC transporter signature motif; other site 536019018830 Walker B; other site 536019018831 D-loop; other site 536019018832 H-loop/switch region; other site 536019018833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536019018834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018835 dimer interface [polypeptide binding]; other site 536019018836 conserved gate region; other site 536019018837 putative PBP binding loops; other site 536019018838 ABC-ATPase subunit interface; other site 536019018839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536019018840 dimer interface [polypeptide binding]; other site 536019018841 conserved gate region; other site 536019018842 putative PBP binding loops; other site 536019018843 ABC-ATPase subunit interface; other site 536019018844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019018845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019018846 substrate binding pocket [chemical binding]; other site 536019018847 membrane-bound complex binding site; other site 536019018848 hinge residues; other site 536019018849 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 536019018850 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 536019018851 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536019018852 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536019018853 putative active site [active] 536019018854 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 536019018855 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 536019018856 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 536019018857 conserved cys residue [active] 536019018858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536019018859 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 536019018860 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 536019018861 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 536019018862 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 536019018863 putative NAD(P) binding site [chemical binding]; other site 536019018864 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 536019018865 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 536019018866 metal binding site [ion binding]; metal-binding site 536019018867 substrate binding pocket [chemical binding]; other site 536019018868 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 536019018869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536019018870 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 536019018871 NAD(P) binding site [chemical binding]; other site 536019018872 catalytic residues [active] 536019018873 catalytic residues [active] 536019018874 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 536019018875 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 536019018876 [2Fe-2S] cluster binding site [ion binding]; other site 536019018877 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 536019018878 hydrophobic ligand binding site; other site 536019018879 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 536019018880 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536019018881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019018882 S-adenosylmethionine binding site [chemical binding]; other site 536019018883 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536019018884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536019018885 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 536019018886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536019018887 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 536019018888 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 536019018889 Transposase domain (DUF772); Region: DUF772; pfam05598 536019018890 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536019018891 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 536019018892 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536019018893 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 536019018894 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 536019018895 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 536019018896 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 536019018897 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019018898 inhibitor-cofactor binding pocket; inhibition site 536019018899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018900 catalytic residue [active] 536019018901 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 536019018902 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 536019018903 acyl-activating enzyme (AAE) consensus motif; other site 536019018904 AMP binding site [chemical binding]; other site 536019018905 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 536019018906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 536019018907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 536019018908 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 536019018909 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 536019018910 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 536019018911 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 536019018912 DNA-binding interface [nucleotide binding]; DNA binding site 536019018913 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019018914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019018915 DNA binding residues [nucleotide binding] 536019018916 dimerization interface [polypeptide binding]; other site 536019018917 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 536019018918 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 536019018919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019018920 catalytic residue [active] 536019018921 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 536019018922 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 536019018923 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 536019018924 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536019018925 catalytic residues [active] 536019018926 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 536019018927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536019018928 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019018929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536019018930 Ligand Binding Site [chemical binding]; other site 536019018931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 536019018932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536019018933 DNA binding site [nucleotide binding] 536019018934 probable nitrogen fixation protein; Region: TIGR02935 536019018935 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 536019018936 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 536019018937 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 536019018938 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 536019018939 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 536019018940 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 536019018941 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 536019018942 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 536019018943 MoFe protein beta/alpha subunit interactions; other site 536019018944 Beta subunit P cluster binding residues; other site 536019018945 MoFe protein beta subunit/Fe protein contacts; other site 536019018946 MoFe protein dimer/ dimer interactions; other site 536019018947 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 536019018948 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 536019018949 MoFe protein alpha/beta subunit interactions; other site 536019018950 Alpha subunit P cluster binding residues; other site 536019018951 FeMoco binding residues [chemical binding]; other site 536019018952 MoFe protein alpha subunit/Fe protein contacts; other site 536019018953 MoFe protein dimer/ dimer interactions; other site 536019018954 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 536019018955 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 536019018956 Nucleotide-binding sites [chemical binding]; other site 536019018957 Walker A motif; other site 536019018958 Switch I region of nucleotide binding site; other site 536019018959 Fe4S4 binding sites [ion binding]; other site 536019018960 Switch II region of nucleotide binding site; other site 536019018961 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536019018962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536019018963 putative substrate translocation pore; other site 536019018964 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 536019018965 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 536019018966 catalytic triad [active] 536019018967 dimer interface [polypeptide binding]; other site 536019018968 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 536019018969 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 536019018970 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 536019018971 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 536019018972 NifQ; Region: NifQ; pfam04891 536019018973 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 536019018974 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 536019018975 short chain dehydrogenase; Validated; Region: PRK06484 536019018976 classical (c) SDRs; Region: SDR_c; cd05233 536019018977 NAD(P) binding site [chemical binding]; other site 536019018978 active site 536019018979 classical (c) SDRs; Region: SDR_c; cd05233 536019018980 NAD(P) binding site [chemical binding]; other site 536019018981 active site 536019018982 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 536019018983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 536019018984 Cytochrome P450; Region: p450; cl12078 536019018985 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 536019018986 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 536019018987 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 536019018988 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 536019018989 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 536019018990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536019018991 catalytic residue [active] 536019018992 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 536019018993 active site 536019018994 catalytic residues [active] 536019018995 metal binding site [ion binding]; metal-binding site 536019018996 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 536019018997 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 536019018998 Ligand binding site [chemical binding]; other site 536019018999 Electron transfer flavoprotein domain; Region: ETF; pfam01012 536019019000 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 536019019001 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 536019019002 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 536019019003 oxidoreductase; Provisional; Region: PRK10015 536019019004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536019019005 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 536019019006 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 536019019007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019019008 FeS/SAM binding site; other site 536019019009 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 536019019010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536019019011 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 536019019012 NifZ domain; Region: NifZ; pfam04319 536019019013 NifT/FixU protein; Region: NifT; pfam06988 536019019014 SIR2-like domain; Region: SIR2_2; pfam13289 536019019015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 536019019016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536019019017 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 536019019018 Walker A/P-loop; other site 536019019019 ATP binding site [chemical binding]; other site 536019019020 Q-loop/lid; other site 536019019021 ABC transporter signature motif; other site 536019019022 Walker B; other site 536019019023 D-loop; other site 536019019024 H-loop/switch region; other site 536019019025 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 536019019026 Nif-specific regulatory protein; Region: nifA; TIGR01817 536019019027 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536019019028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536019019029 Walker A motif; other site 536019019030 ATP binding site [chemical binding]; other site 536019019031 Walker B motif; other site 536019019032 arginine finger; other site 536019019033 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536019019034 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 536019019035 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536019019036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536019019037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536019019038 DNA binding site [nucleotide binding] 536019019039 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 536019019040 putative ligand binding site [chemical binding]; other site 536019019041 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 536019019042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019019043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019019044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019019045 dimerization interface [polypeptide binding]; other site 536019019046 Nodulation protein A (NodA); Region: NodA; pfam02474 536019019047 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 536019019048 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 536019019049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536019019050 dimer interface [polypeptide binding]; other site 536019019051 active site 536019019052 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 536019019053 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 536019019054 NAD(P) binding site [chemical binding]; other site 536019019055 homotetramer interface [polypeptide binding]; other site 536019019056 homodimer interface [polypeptide binding]; other site 536019019057 active site 536019019058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019019059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019019060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019019061 N-acyltransferase NodA; Region: nodulat_NodA; TIGR04245 536019019062 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 536019019063 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 536019019064 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 536019019065 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 536019019066 DXD motif; other site 536019019067 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 536019019068 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 536019019069 Walker A/P-loop; other site 536019019070 ATP binding site [chemical binding]; other site 536019019071 Q-loop/lid; other site 536019019072 ABC transporter signature motif; other site 536019019073 Walker B; other site 536019019074 D-loop; other site 536019019075 H-loop/switch region; other site 536019019076 ABC-2 type transporter; Region: ABC2_membrane; cl17235 536019019077 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536019019078 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 536019019079 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 536019019080 Transposase; Region: HTH_Tnp_1; pfam01527 536019019081 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 536019019082 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 536019019083 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 536019019084 B3/4 domain; Region: B3_4; pfam03483 536019019085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019019086 DNA-binding site [nucleotide binding]; DNA binding site 536019019087 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536019019088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019019089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019019090 homodimer interface [polypeptide binding]; other site 536019019091 catalytic residue [active] 536019019092 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 536019019093 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 536019019094 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 536019019095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536019019096 non-specific DNA binding site [nucleotide binding]; other site 536019019097 salt bridge; other site 536019019098 sequence-specific DNA binding site [nucleotide binding]; other site 536019019099 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536019019100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536019019101 DNA-binding site [nucleotide binding]; DNA binding site 536019019102 FCD domain; Region: FCD; pfam07729 536019019103 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 536019019104 dimer interface [polypeptide binding]; other site 536019019105 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 536019019106 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 536019019107 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 536019019108 CHAT domain; Region: CHAT; cl17868 536019019109 CHAT domain; Region: CHAT; cl17868 536019019110 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 536019019111 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 536019019112 Caspase domain; Region: Peptidase_C14; pfam00656 536019019113 ski2-like helicase; Provisional; Region: PRK00254 536019019114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019019115 ATP binding site [chemical binding]; other site 536019019116 putative Mg++ binding site [ion binding]; other site 536019019117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019019118 nucleotide binding region [chemical binding]; other site 536019019119 ATP-binding site [chemical binding]; other site 536019019120 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 536019019121 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 536019019122 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 536019019123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536019019124 Coenzyme A binding pocket [chemical binding]; other site 536019019125 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 536019019126 catalytic residue [active] 536019019127 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536019019128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 536019019129 oligomerisation interface [polypeptide binding]; other site 536019019130 mobile loop; other site 536019019131 roof hairpin; other site 536019019132 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 536019019133 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 536019019134 ring oligomerisation interface [polypeptide binding]; other site 536019019135 ATP/Mg binding site [chemical binding]; other site 536019019136 stacking interactions; other site 536019019137 hinge regions; other site 536019019138 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 536019019139 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 536019019140 ADP binding site [chemical binding]; other site 536019019141 magnesium binding site [ion binding]; other site 536019019142 putative shikimate binding site; other site 536019019143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 536019019144 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536019019145 catalytic residues [active] 536019019146 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 536019019147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 536019019148 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536019019149 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 536019019150 substrate binding site [chemical binding]; other site 536019019151 ATP binding site [chemical binding]; other site 536019019152 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 536019019153 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019019154 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 536019019155 putative dimer interface [polypeptide binding]; other site 536019019156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536019019157 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536019019158 putative dimer interface [polypeptide binding]; other site 536019019159 Protein of unknown function (DUF982); Region: DUF982; pfam06169 536019019160 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 536019019161 putative hydrophobic ligand binding site [chemical binding]; other site 536019019162 protein interface [polypeptide binding]; other site 536019019163 gate; other site 536019019164 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 536019019165 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 536019019166 Subunit I/III interface [polypeptide binding]; other site 536019019167 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536019019168 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 536019019169 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 536019019170 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536019019171 Cytochrome c; Region: Cytochrom_C; cl11414 536019019172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 536019019173 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 536019019174 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 536019019175 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 536019019176 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 536019019177 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536019019178 molybdopterin cofactor binding site; other site 536019019179 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 536019019180 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 536019019181 4Fe-4S binding domain; Region: Fer4_2; pfam12797 536019019182 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 536019019183 heme-binding residues [chemical binding]; other site 536019019184 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 536019019185 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 536019019186 Trp docking motif [polypeptide binding]; other site 536019019187 putative active site [active] 536019019188 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 536019019189 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536019019190 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 536019019191 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 536019019192 active site 536019019193 DNA binding site [nucleotide binding] 536019019194 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 536019019195 DNA binding site [nucleotide binding] 536019019196 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 536019019197 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 536019019198 putative molybdopterin cofactor binding site [chemical binding]; other site 536019019199 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 536019019200 putative molybdopterin cofactor binding site; other site 536019019201 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 536019019202 thiamine pyrophosphate protein; Provisional; Region: PRK08273 536019019203 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 536019019204 PYR/PP interface [polypeptide binding]; other site 536019019205 dimer interface [polypeptide binding]; other site 536019019206 tetramer interface [polypeptide binding]; other site 536019019207 TPP binding site [chemical binding]; other site 536019019208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536019019209 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 536019019210 TPP-binding site [chemical binding]; other site 536019019211 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019019212 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019019213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019019214 active site 536019019215 phosphorylation site [posttranslational modification] 536019019216 intermolecular recognition site; other site 536019019217 dimerization interface [polypeptide binding]; other site 536019019218 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536019019219 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 536019019220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019019221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019019222 NAD(P) binding site [chemical binding]; other site 536019019223 active site 536019019224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019019225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019019226 NAD(P) binding site [chemical binding]; other site 536019019227 active site 536019019228 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 536019019229 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 536019019230 B12 binding site [chemical binding]; other site 536019019231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536019019232 FeS/SAM binding site; other site 536019019233 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536019019234 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 536019019235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 536019019236 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536019019237 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 536019019238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 536019019239 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 536019019240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 536019019241 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 536019019242 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 536019019243 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536019019244 NAD binding site [chemical binding]; other site 536019019245 putative substrate binding site 2 [chemical binding]; other site 536019019246 putative substrate binding site 1 [chemical binding]; other site 536019019247 active site 536019019248 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 536019019249 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 536019019250 Subunit I/III interface [polypeptide binding]; other site 536019019251 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536019019252 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 536019019253 D-pathway; other site 536019019254 Putative ubiquinol binding site [chemical binding]; other site 536019019255 Low-spin heme (heme b) binding site [chemical binding]; other site 536019019256 Putative water exit pathway; other site 536019019257 Binuclear center (heme o3/CuB) [ion binding]; other site 536019019258 K-pathway; other site 536019019259 Putative proton exit pathway; other site 536019019260 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 536019019261 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536019019262 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 536019019263 Cytochrome c; Region: Cytochrom_C; cl11414 536019019264 Cytochrome c; Region: Cytochrom_C; cl11414 536019019265 Cytochrome c; Region: Cytochrom_C; pfam00034 536019019266 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 536019019267 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 536019019268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536019019269 catalytic core [active] 536019019270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 536019019271 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 536019019272 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 536019019273 active site 536019019274 Substrate binding site; other site 536019019275 Mg++ binding site; other site 536019019276 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536019019277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019019278 S-adenosylmethionine binding site [chemical binding]; other site 536019019279 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 536019019280 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 536019019281 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 536019019282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536019019283 putative ADP-binding pocket [chemical binding]; other site 536019019284 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 536019019285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 536019019286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536019019287 S-adenosylmethionine binding site [chemical binding]; other site 536019019288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536019019289 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 536019019290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536019019291 DNA binding residues [nucleotide binding] 536019019292 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 536019019293 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 536019019294 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019019295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019019296 active site 536019019297 phosphorylation site [posttranslational modification] 536019019298 intermolecular recognition site; other site 536019019299 dimerization interface [polypeptide binding]; other site 536019019300 CheB methylesterase; Region: CheB_methylest; pfam01339 536019019301 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 536019019302 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 536019019303 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 536019019304 PAS domain; Region: PAS_10; pfam13596 536019019305 PAS domain; Region: PAS_9; pfam13426 536019019306 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 536019019307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 536019019308 HWE histidine kinase; Region: HWE_HK; pfam07536 536019019309 CheB methylesterase; Region: CheB_methylest; pfam01339 536019019310 CsbD-like; Region: CsbD; cl17424 536019019311 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 536019019312 short chain dehydrogenase; Provisional; Region: PRK06701 536019019313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536019019314 NAD(P) binding site [chemical binding]; other site 536019019315 active site 536019019316 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 536019019317 dimerization interface [polypeptide binding]; other site 536019019318 metal binding site [ion binding]; metal-binding site 536019019319 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 536019019320 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 536019019321 putative catalytic residues [active] 536019019322 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 536019019323 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 536019019324 Protein of unknown function (DUF768); Region: DUF768; pfam05589 536019019325 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 536019019326 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 536019019327 FecCD transport family; Region: FecCD; pfam01032 536019019328 ABC-ATPase subunit interface; other site 536019019329 dimer interface [polypeptide binding]; other site 536019019330 putative PBP binding regions; other site 536019019331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536019019332 ABC-ATPase subunit interface; other site 536019019333 dimer interface [polypeptide binding]; other site 536019019334 putative PBP binding regions; other site 536019019335 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 536019019336 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 536019019337 siderophore binding site; other site 536019019338 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 536019019339 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 536019019340 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 536019019341 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 536019019342 short chain dehydrogenase; Validated; Region: PRK08324 536019019343 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 536019019344 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 536019019345 putative NAD(P) binding site [chemical binding]; other site 536019019346 active site 536019019347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536019019348 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536019019349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536019019350 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 536019019351 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 536019019352 ligand binding site [chemical binding]; other site 536019019353 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019019354 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019019355 Walker A/P-loop; other site 536019019356 ATP binding site [chemical binding]; other site 536019019357 Q-loop/lid; other site 536019019358 ABC transporter signature motif; other site 536019019359 Walker B; other site 536019019360 D-loop; other site 536019019361 H-loop/switch region; other site 536019019362 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019019363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019019364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019019365 TM-ABC transporter signature motif; other site 536019019366 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019019367 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019019368 TM-ABC transporter signature motif; other site 536019019369 Uncharacterized conserved protein [Function unknown]; Region: COG3254 536019019370 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536019019371 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 536019019372 N- and C-terminal domain interface [polypeptide binding]; other site 536019019373 putative active site [active] 536019019374 putative MgATP binding site [chemical binding]; other site 536019019375 putative catalytic site [active] 536019019376 metal binding site [ion binding]; metal-binding site 536019019377 putative carbohydrate binding site [chemical binding]; other site 536019019378 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 536019019379 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536019019380 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 536019019381 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 536019019382 NAD binding site [chemical binding]; other site 536019019383 homodimer interface [polypeptide binding]; other site 536019019384 active site 536019019385 substrate binding site [chemical binding]; other site 536019019386 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 536019019387 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 536019019388 substrate-cofactor binding pocket; other site 536019019389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019019390 catalytic residue [active] 536019019391 aspartate aminotransferase; Provisional; Region: PRK06108 536019019392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536019019393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019019394 homodimer interface [polypeptide binding]; other site 536019019395 catalytic residue [active] 536019019396 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 536019019397 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 536019019398 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 536019019399 Na binding site [ion binding]; other site 536019019400 PAS fold; Region: PAS_7; pfam12860 536019019401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536019019402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019019403 dimer interface [polypeptide binding]; other site 536019019404 phosphorylation site [posttranslational modification] 536019019405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019019406 ATP binding site [chemical binding]; other site 536019019407 Mg2+ binding site [ion binding]; other site 536019019408 G-X-G motif; other site 536019019409 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 536019019410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019019411 active site 536019019412 phosphorylation site [posttranslational modification] 536019019413 intermolecular recognition site; other site 536019019414 dimerization interface [polypeptide binding]; other site 536019019415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536019019416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536019019417 active site 536019019418 phosphorylation site [posttranslational modification] 536019019419 intermolecular recognition site; other site 536019019420 dimerization interface [polypeptide binding]; other site 536019019421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019019422 DNA binding residues [nucleotide binding] 536019019423 dimerization interface [polypeptide binding]; other site 536019019424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 536019019425 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 536019019426 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 536019019427 quinone interaction residues [chemical binding]; other site 536019019428 active site 536019019429 catalytic residues [active] 536019019430 FMN binding site [chemical binding]; other site 536019019431 substrate binding site [chemical binding]; other site 536019019432 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 536019019433 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 536019019434 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 536019019435 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 536019019436 putative active site [active] 536019019437 Zn binding site [ion binding]; other site 536019019438 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 536019019439 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 536019019440 Ligand binding site; other site 536019019441 Putative Catalytic site; other site 536019019442 DXD motif; other site 536019019443 Predicted membrane protein [Function unknown]; Region: COG2246 536019019444 GtrA-like protein; Region: GtrA; pfam04138 536019019445 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 536019019446 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 536019019447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019019448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019019449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536019019450 dimerization interface [polypeptide binding]; other site 536019019451 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 536019019452 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 536019019453 putative ligand binding site [chemical binding]; other site 536019019454 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536019019455 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536019019456 Walker A/P-loop; other site 536019019457 ATP binding site [chemical binding]; other site 536019019458 Q-loop/lid; other site 536019019459 ABC transporter signature motif; other site 536019019460 Walker B; other site 536019019461 D-loop; other site 536019019462 H-loop/switch region; other site 536019019463 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536019019464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019019465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019019466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536019019467 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536019019468 TM-ABC transporter signature motif; other site 536019019469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 536019019470 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 536019019471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019019472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019019473 substrate binding pocket [chemical binding]; other site 536019019474 membrane-bound complex binding site; other site 536019019475 hinge residues; other site 536019019476 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 536019019477 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 536019019478 trimer interface [polypeptide binding]; other site 536019019479 active site 536019019480 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 536019019481 trimer interface [polypeptide binding]; other site 536019019482 active site 536019019483 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 536019019484 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536019019485 homodimer interface [polypeptide binding]; other site 536019019486 substrate-cofactor binding pocket; other site 536019019487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019019488 catalytic residue [active] 536019019489 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 536019019490 ligand binding site; other site 536019019491 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 536019019492 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 536019019493 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 536019019494 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 536019019495 dimerization interface [polypeptide binding]; other site 536019019496 domain crossover interface; other site 536019019497 redox-dependent activation switch; other site 536019019498 ornithine carbamoyltransferase; Provisional; Region: PRK00779 536019019499 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536019019500 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536019019501 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 536019019502 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536019019503 inhibitor-cofactor binding pocket; inhibition site 536019019504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536019019505 catalytic residue [active] 536019019506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 536019019507 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536019019508 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 536019019509 oligomer interface [polypeptide binding]; other site 536019019510 metal binding site [ion binding]; metal-binding site 536019019511 metal binding site [ion binding]; metal-binding site 536019019512 putative Cl binding site [ion binding]; other site 536019019513 basic sphincter; other site 536019019514 hydrophobic gate; other site 536019019515 periplasmic entrance; other site 536019019516 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 536019019517 PhoU domain; Region: PhoU; pfam01895 536019019518 PhoU domain; Region: PhoU; pfam01895 536019019519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536019019520 dimer interface [polypeptide binding]; other site 536019019521 phosphorylation site [posttranslational modification] 536019019522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536019019523 ATP binding site [chemical binding]; other site 536019019524 Mg2+ binding site [ion binding]; other site 536019019525 G-X-G motif; other site 536019019526 Uncharacterized conserved protein [Function unknown]; Region: COG2326 536019019527 enoyl-CoA hydratase; Provisional; Region: PRK06688 536019019528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019019529 substrate binding site [chemical binding]; other site 536019019530 oxyanion hole (OAH) forming residues; other site 536019019531 trimer interface [polypeptide binding]; other site 536019019532 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 536019019533 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 536019019534 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536019019535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536019019536 DNA binding residues [nucleotide binding] 536019019537 dimerization interface [polypeptide binding]; other site 536019019538 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 536019019539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536019019540 substrate binding pocket [chemical binding]; other site 536019019541 membrane-bound complex binding site; other site 536019019542 tellurite resistance protein terB; Region: terB; cd07176 536019019543 putative metal binding site [ion binding]; other site 536019019544 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 536019019545 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 536019019546 active site 536019019547 HIGH motif; other site 536019019548 KMSKS motif; other site 536019019549 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 536019019550 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 536019019551 Predicted transcriptional regulator [Transcription]; Region: COG2932 536019019552 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536019019553 Catalytic site [active] 536019019554 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536019019555 active site 536019019556 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 536019019557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019019558 substrate binding site [chemical binding]; other site 536019019559 oxyanion hole (OAH) forming residues; other site 536019019560 trimer interface [polypeptide binding]; other site 536019019561 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536019019562 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019019563 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536019019564 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 536019019565 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536019019566 dimer interface [polypeptide binding]; other site 536019019567 active site 536019019568 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 536019019569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 536019019570 active site 536019019571 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 536019019572 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 536019019573 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 536019019574 FAD binding site [chemical binding]; other site 536019019575 substrate binding site [chemical binding]; other site 536019019576 catalytic residues [active] 536019019577 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 536019019578 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 536019019579 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 536019019580 DNA binding residues [nucleotide binding] 536019019581 putative dimer interface [polypeptide binding]; other site 536019019582 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536019019583 Sel1-like repeats; Region: SEL1; smart00671 536019019584 Sel1-like repeats; Region: SEL1; smart00671 536019019585 Sel1-like repeats; Region: SEL1; smart00671 536019019586 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536019019587 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 536019019588 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 536019019589 putative chaperone; Provisional; Region: PRK11678 536019019590 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 536019019591 nucleotide binding site [chemical binding]; other site 536019019592 putative NEF/HSP70 interaction site [polypeptide binding]; other site 536019019593 SBD interface [polypeptide binding]; other site 536019019594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536019019595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536019019596 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 536019019597 putative dimerization interface [polypeptide binding]; other site 536019019598 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 536019019599 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536019019600 molybdopterin cofactor binding site; other site 536019019601 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536019019602 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 536019019603 putative molybdopterin cofactor binding site; other site 536019019604 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 536019019605 4Fe-4S binding domain; Region: Fer4; pfam00037 536019019606 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 536019019607 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536019019608 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 536019019609 putative active site [active] 536019019610 putative metal binding site [ion binding]; other site 536019019611 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 536019019612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536019019613 ATP binding site [chemical binding]; other site 536019019614 putative Mg++ binding site [ion binding]; other site 536019019615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536019019616 nucleotide binding region [chemical binding]; other site 536019019617 ATP-binding site [chemical binding]; other site 536019019618 DEAD/H associated; Region: DEAD_assoc; pfam08494 536019019619 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 536019019620 NlpC/P60 family; Region: NLPC_P60; cl17555 536019019621 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536019019622 MarR family; Region: MarR; pfam01047 536019019623 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 536019019624 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 536019019625 interface (dimer of trimers) [polypeptide binding]; other site 536019019626 Substrate-binding/catalytic site; other site 536019019627 Zn-binding sites [ion binding]; other site 536019019628 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 536019019629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019019630 TPR motif; other site 536019019631 binding surface 536019019632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536019019633 TPR motif; other site 536019019634 binding surface 536019019635 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 536019019636 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019019637 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 536019019638 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536019019639 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 536019019640 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 536019019641 ATP binding site [chemical binding]; other site 536019019642 Walker A motif; other site 536019019643 hexamer interface [polypeptide binding]; other site 536019019644 Walker B motif; other site 536019019645 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 536019019646 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 536019019647 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 536019019648 Type IV pili component [Cell motility and secretion]; Region: COG5461 536019019649 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 536019019650 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 536019019651 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 536019019652 BON domain; Region: BON; pfam04972 536019019653 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 536019019654 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 536019019655 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 536019019656 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 536019019657 Flp/Fap pilin component; Region: Flp_Fap; cl01585 536019019658 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 536019019659 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019019660 TadE-like protein; Region: TadE; pfam07811 536019019661 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 536019019662 TadE-like protein; Region: TadE; pfam07811 536019019663 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 536019019664 phosphopentomutase; Provisional; Region: PRK05362 536019019665 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 536019019666 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 536019019667 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 536019019668 DNA binding site [nucleotide binding] 536019019669 catalytic residue [active] 536019019670 H2TH interface [polypeptide binding]; other site 536019019671 putative catalytic residues [active] 536019019672 turnover-facilitating residue; other site 536019019673 intercalation triad [nucleotide binding]; other site 536019019674 8OG recognition residue [nucleotide binding]; other site 536019019675 putative reading head residues; other site 536019019676 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 536019019677 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 536019019678 enoyl-CoA hydratase; Provisional; Region: PRK05862 536019019679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536019019680 substrate binding site [chemical binding]; other site 536019019681 oxyanion hole (OAH) forming residues; other site 536019019682 trimer interface [polypeptide binding]; other site 536019019683 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239