-- dump date 20140619_144107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 426117000001 Terminase-like family; Region: Terminase_6; pfam03237 426117000002 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 426117000003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117000004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117000005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426117000006 IHF dimer interface [polypeptide binding]; other site 426117000007 IHF - DNA interface [nucleotide binding]; other site 426117000008 CsbD-like; Region: CsbD; pfam05532 426117000009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426117000010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117000011 P-loop; other site 426117000012 Magnesium ion binding site [ion binding]; other site 426117000013 Replication initiator protein A; Region: RPA; pfam10134 426117000014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117000015 Transposase; Region: HTH_Tnp_1; pfam01527 426117000016 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117000017 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 426117000018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117000019 catalytic residues [active] 426117000020 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 426117000021 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 426117000022 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426117000023 Omptin family; Region: Omptin; cl01886 426117000024 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 426117000025 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 426117000026 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117000027 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117000028 catalytic residues [active] 426117000029 catalytic nucleophile [active] 426117000030 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117000031 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117000032 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117000033 Synaptic Site I dimer interface [polypeptide binding]; other site 426117000034 DNA binding site [nucleotide binding] 426117000035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426117000036 DNA-binding interface [nucleotide binding]; DNA binding site 426117000037 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117000038 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117000039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117000040 Walker A motif; other site 426117000041 ATP binding site [chemical binding]; other site 426117000042 Walker B motif; other site 426117000043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117000044 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117000045 Integrase core domain; Region: rve; pfam00665 426117000046 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117000047 MULE transposase domain; Region: MULE; pfam10551 426117000048 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 426117000049 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 426117000050 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117000051 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 426117000052 putative active site [active] 426117000053 metal binding site [ion binding]; metal-binding site 426117000054 acetolactate synthase; Reviewed; Region: PRK08322 426117000055 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117000056 PYR/PP interface [polypeptide binding]; other site 426117000057 dimer interface [polypeptide binding]; other site 426117000058 TPP binding site [chemical binding]; other site 426117000059 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117000060 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 426117000061 TPP-binding site [chemical binding]; other site 426117000062 dimer interface [polypeptide binding]; other site 426117000063 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426117000064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117000065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426117000066 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 426117000067 DDE domain; Region: DDE_Tnp_IS240; pfam13610 426117000068 Integrase core domain; Region: rve; pfam00665 426117000069 acyl-CoA synthetase; Validated; Region: PRK08162 426117000070 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 426117000071 acyl-activating enzyme (AAE) consensus motif; other site 426117000072 putative active site [active] 426117000073 AMP binding site [chemical binding]; other site 426117000074 putative CoA binding site [chemical binding]; other site 426117000075 hypothetical protein; Provisional; Region: PRK14709 426117000076 D5 N terminal like; Region: D5_N; pfam08706 426117000077 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117000078 multiple promoter invertase; Provisional; Region: mpi; PRK13413 426117000079 catalytic residues [active] 426117000080 catalytic nucleophile [active] 426117000081 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117000082 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117000083 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117000084 Synaptic Site I dimer interface [polypeptide binding]; other site 426117000085 DNA binding site [nucleotide binding] 426117000086 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 426117000087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117000088 Magnesium ion binding site [ion binding]; other site 426117000089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117000090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117000091 non-specific DNA binding site [nucleotide binding]; other site 426117000092 salt bridge; other site 426117000093 sequence-specific DNA binding site [nucleotide binding]; other site 426117000094 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117000095 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 426117000096 active site 426117000097 metal binding site [ion binding]; metal-binding site 426117000098 interdomain interaction site; other site 426117000099 Archaeal DNA polymerase II, large subunit [DNA replication, recombination, and repair]; Region: COG1933 426117000100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 426117000101 putative Zn2+ binding site [ion binding]; other site 426117000102 putative DNA binding site [nucleotide binding]; other site 426117000103 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117000104 multiple promoter invertase; Provisional; Region: mpi; PRK13413 426117000105 catalytic residues [active] 426117000106 catalytic nucleophile [active] 426117000107 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117000108 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117000109 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117000110 Synaptic Site I dimer interface [polypeptide binding]; other site 426117000111 DNA binding site [nucleotide binding] 426117000112 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426117000113 DNA-binding interface [nucleotide binding]; DNA binding site 426117000114 AAA domain; Region: AAA_23; pfam13476 426117000115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000116 AAA domain; Region: AAA_21; pfam13304 426117000117 Walker A/P-loop; other site 426117000118 ATP binding site [chemical binding]; other site 426117000119 TIGR02646 family protein; Region: TIGR02646 426117000120 DnaA N-terminal domain; Region: DnaA_N; pfam11638 426117000121 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 426117000122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117000123 Walker A motif; other site 426117000124 ATP binding site [chemical binding]; other site 426117000125 Walker B motif; other site 426117000126 arginine finger; other site 426117000127 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 426117000128 DnaA box-binding interface [nucleotide binding]; other site 426117000129 DNA polymerase III subunit beta; Validated; Region: PRK05643 426117000130 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 426117000131 putative DNA binding surface [nucleotide binding]; other site 426117000132 dimer interface [polypeptide binding]; other site 426117000133 beta-clamp/clamp loader binding surface; other site 426117000134 beta-clamp/translesion DNA polymerase binding surface; other site 426117000135 recombination protein F; Reviewed; Region: recF; PRK00064 426117000136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000137 Walker A/P-loop; other site 426117000138 ATP binding site [chemical binding]; other site 426117000139 Q-loop/lid; other site 426117000140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000141 ABC transporter signature motif; other site 426117000142 Walker B; other site 426117000143 D-loop; other site 426117000144 H-loop/switch region; other site 426117000145 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 426117000146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117000147 ATP binding site [chemical binding]; other site 426117000148 putative Mg++ binding site [ion binding]; other site 426117000149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117000150 nucleotide binding region [chemical binding]; other site 426117000151 ATP-binding site [chemical binding]; other site 426117000152 RQC domain; Region: RQC; pfam09382 426117000153 HRDC domain; Region: HRDC; pfam00570 426117000154 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 426117000155 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 426117000156 dimerization interface [polypeptide binding]; other site 426117000157 ATP binding site [chemical binding]; other site 426117000158 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 426117000159 dimerization interface [polypeptide binding]; other site 426117000160 ATP binding site [chemical binding]; other site 426117000161 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 426117000162 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 426117000163 putative GSH binding site [chemical binding]; other site 426117000164 catalytic residues [active] 426117000165 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117000166 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 426117000167 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 426117000168 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 426117000169 active site 426117000170 Zn binding site [ion binding]; other site 426117000171 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 426117000172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117000173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117000174 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117000175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426117000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426117000177 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 426117000178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117000179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000180 active site 426117000181 phosphorylation site [posttranslational modification] 426117000182 intermolecular recognition site; other site 426117000183 dimerization interface [polypeptide binding]; other site 426117000184 hypothetical protein; Provisional; Region: PRK14679 426117000185 Predicted methyltransferases [General function prediction only]; Region: COG0313 426117000186 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 426117000187 putative SAM binding site [chemical binding]; other site 426117000188 putative homodimer interface [polypeptide binding]; other site 426117000189 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 426117000190 putative ligand binding site [chemical binding]; other site 426117000191 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 426117000192 Flagellin N-methylase; Region: FliB; cl00497 426117000193 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117000194 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 426117000195 Caspase domain; Region: Peptidase_C14; pfam00656 426117000196 Bacterial SH3 domain; Region: SH3_3; pfam08239 426117000197 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 426117000198 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 426117000199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117000200 Zn2+ binding site [ion binding]; other site 426117000201 Mg2+ binding site [ion binding]; other site 426117000202 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426117000203 synthetase active site [active] 426117000204 NTP binding site [chemical binding]; other site 426117000205 metal binding site [ion binding]; metal-binding site 426117000206 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 426117000207 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 426117000208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117000209 active site 426117000210 Uncharacterized conserved protein [Function unknown]; Region: COG1432 426117000211 LabA_like proteins; Region: LabA; cd10911 426117000212 putative metal binding site [ion binding]; other site 426117000213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117000214 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117000215 NAD(P) binding site [chemical binding]; other site 426117000216 active site 426117000217 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 426117000218 putative catalytic motif [active] 426117000219 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 426117000220 putative active site [active] 426117000221 putative substrate binding site [chemical binding]; other site 426117000222 putative coenzyme B12 binding site [chemical binding]; other site 426117000223 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 426117000224 B12 binding site [chemical binding]; other site 426117000225 cobalt ligand [ion binding]; other site 426117000226 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 426117000227 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 426117000228 putative NAD(P) binding site [chemical binding]; other site 426117000229 Predicted membrane protein [Function unknown]; Region: COG2259 426117000230 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 426117000231 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 426117000232 substrate binding site [chemical binding]; other site 426117000233 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426117000234 murein hydrolase B; Provisional; Region: PRK10760; cl17906 426117000235 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117000236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117000237 metal binding site [ion binding]; metal-binding site 426117000238 active site 426117000239 I-site; other site 426117000240 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117000241 cyanate transporter; Region: CynX; TIGR00896 426117000242 heat shock protein 90; Provisional; Region: PRK05218 426117000243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000244 ATP binding site [chemical binding]; other site 426117000245 G-X-G motif; other site 426117000246 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426117000247 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 426117000248 active site 426117000249 catalytic site [active] 426117000250 substrate binding site [chemical binding]; other site 426117000251 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 426117000252 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117000253 ligand binding site [chemical binding]; other site 426117000254 flexible hinge region; other site 426117000255 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426117000256 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426117000257 metal binding triad; other site 426117000258 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 426117000259 putative active site [active] 426117000260 putative catalytic site [active] 426117000261 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117000262 putative efflux protein, MATE family; Region: matE; TIGR00797 426117000263 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117000264 MarR family; Region: MarR_2; pfam12802 426117000265 benzoate transport; Region: 2A0115; TIGR00895 426117000266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117000267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117000268 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 426117000269 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426117000270 Aminotransferase class IV; Region: Aminotran_4; pfam01063 426117000271 substrate-cofactor binding pocket; other site 426117000272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117000273 catalytic residue [active] 426117000274 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 426117000275 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426117000276 glutamine binding [chemical binding]; other site 426117000277 catalytic triad [active] 426117000278 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 426117000279 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 426117000280 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 426117000281 NMT1-like family; Region: NMT1_2; pfam13379 426117000282 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117000283 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117000284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426117000285 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117000286 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117000287 Walker A/P-loop; other site 426117000288 ATP binding site [chemical binding]; other site 426117000289 Q-loop/lid; other site 426117000290 ABC transporter signature motif; other site 426117000291 Walker B; other site 426117000292 D-loop; other site 426117000293 H-loop/switch region; other site 426117000294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117000295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000296 active site 426117000297 phosphorylation site [posttranslational modification] 426117000298 intermolecular recognition site; other site 426117000299 dimerization interface [polypeptide binding]; other site 426117000300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117000301 DNA binding site [nucleotide binding] 426117000302 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 426117000303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117000304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000305 dimer interface [polypeptide binding]; other site 426117000306 phosphorylation site [posttranslational modification] 426117000307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000308 Mg2+ binding site [ion binding]; other site 426117000309 G-X-G motif; other site 426117000310 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426117000311 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 426117000312 substrate binding site [chemical binding]; other site 426117000313 Erythromycin esterase; Region: Erythro_esteras; pfam05139 426117000314 putative hydrolase; Provisional; Region: PRK11460 426117000315 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117000316 Amino acid permease; Region: AA_permease_2; pfam13520 426117000317 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 426117000318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 426117000319 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 426117000320 Walker A/P-loop; other site 426117000321 ATP binding site [chemical binding]; other site 426117000322 Q-loop/lid; other site 426117000323 ABC transporter signature motif; other site 426117000324 Walker B; other site 426117000325 D-loop; other site 426117000326 H-loop/switch region; other site 426117000327 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 426117000328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 426117000329 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426117000330 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 426117000331 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 426117000332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117000333 Ligand Binding Site [chemical binding]; other site 426117000334 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426117000335 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 426117000336 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117000337 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426117000338 Walker A/P-loop; other site 426117000339 ATP binding site [chemical binding]; other site 426117000340 Q-loop/lid; other site 426117000341 ABC transporter signature motif; other site 426117000342 Walker B; other site 426117000343 D-loop; other site 426117000344 H-loop/switch region; other site 426117000345 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426117000346 Walker A/P-loop; other site 426117000347 ATP binding site [chemical binding]; other site 426117000348 Q-loop/lid; other site 426117000349 ABC transporter signature motif; other site 426117000350 Walker B; other site 426117000351 D-loop; other site 426117000352 H-loop/switch region; other site 426117000353 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426117000354 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 426117000355 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117000356 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 426117000357 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117000358 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 426117000359 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117000360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000361 Walker A/P-loop; other site 426117000362 ATP binding site [chemical binding]; other site 426117000363 Q-loop/lid; other site 426117000364 ABC transporter signature motif; other site 426117000365 Walker B; other site 426117000366 D-loop; other site 426117000367 H-loop/switch region; other site 426117000368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 426117000369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117000370 putative homodimer interface [polypeptide binding]; other site 426117000371 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 426117000372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117000373 UDP-galactopyranose mutase; Region: GLF; pfam03275 426117000374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117000375 ligand binding site [chemical binding]; other site 426117000376 flexible hinge region; other site 426117000377 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 426117000378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000379 Walker A/P-loop; other site 426117000380 ATP binding site [chemical binding]; other site 426117000381 Q-loop/lid; other site 426117000382 ABC transporter signature motif; other site 426117000383 Walker B; other site 426117000384 D-loop; other site 426117000385 H-loop/switch region; other site 426117000386 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 426117000387 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 426117000388 putative active site [active] 426117000389 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000391 Walker A/P-loop; other site 426117000392 ATP binding site [chemical binding]; other site 426117000393 Q-loop/lid; other site 426117000394 ABC transporter signature motif; other site 426117000395 Walker B; other site 426117000396 D-loop; other site 426117000397 H-loop/switch region; other site 426117000398 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 426117000399 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117000400 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 426117000401 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426117000402 B12 binding site [chemical binding]; other site 426117000403 TIGR04076 family protein; Region: TIGR04076 426117000404 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 426117000405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 426117000406 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117000407 FeS/SAM binding site; other site 426117000408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117000409 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117000410 FeS/SAM binding site; other site 426117000411 SpaB C-terminal domain; Region: SpaB_C; pfam14028 426117000412 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 426117000413 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 426117000414 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 426117000415 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 426117000416 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 426117000417 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 426117000418 DXD motif; other site 426117000419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000420 Response regulator receiver domain; Region: Response_reg; pfam00072 426117000421 active site 426117000422 phosphorylation site [posttranslational modification] 426117000423 intermolecular recognition site; other site 426117000424 dimerization interface [polypeptide binding]; other site 426117000425 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 426117000426 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426117000427 NAD binding site [chemical binding]; other site 426117000428 catalytic Zn binding site [ion binding]; other site 426117000429 structural Zn binding site [ion binding]; other site 426117000430 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 426117000431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117000432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117000433 Walker A/P-loop; other site 426117000434 ATP binding site [chemical binding]; other site 426117000435 Q-loop/lid; other site 426117000436 ABC transporter signature motif; other site 426117000437 Walker B; other site 426117000438 D-loop; other site 426117000439 H-loop/switch region; other site 426117000440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117000441 dimer interface [polypeptide binding]; other site 426117000442 ABC-ATPase subunit interface; other site 426117000443 putative PBP binding loops; other site 426117000444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117000445 dimer interface [polypeptide binding]; other site 426117000446 conserved gate region; other site 426117000447 putative PBP binding loops; other site 426117000448 ABC-ATPase subunit interface; other site 426117000449 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117000450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117000451 substrate binding pocket [chemical binding]; other site 426117000452 membrane-bound complex binding site; other site 426117000453 hinge residues; other site 426117000454 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 426117000455 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117000456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117000457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117000458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117000459 dimerization interface [polypeptide binding]; other site 426117000460 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117000461 Phosphotransferase enzyme family; Region: APH; pfam01636 426117000462 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 426117000463 enolase; Provisional; Region: eno; PRK00077 426117000464 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 426117000465 dimer interface [polypeptide binding]; other site 426117000466 metal binding site [ion binding]; metal-binding site 426117000467 substrate binding pocket [chemical binding]; other site 426117000468 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 426117000469 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 426117000470 active site residue [active] 426117000471 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426117000472 Sulphur transport; Region: Sulf_transp; pfam04143 426117000473 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 426117000474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117000475 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117000476 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 426117000477 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426117000478 catalytic residues [active] 426117000479 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 426117000480 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 426117000481 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117000482 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 426117000483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000484 active site 426117000485 phosphorylation site [posttranslational modification] 426117000486 intermolecular recognition site; other site 426117000487 dimerization interface [polypeptide binding]; other site 426117000488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117000489 DNA binding site [nucleotide binding] 426117000490 sensor protein QseC; Provisional; Region: PRK10337 426117000491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000492 dimer interface [polypeptide binding]; other site 426117000493 phosphorylation site [posttranslational modification] 426117000494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000495 ATP binding site [chemical binding]; other site 426117000496 Mg2+ binding site [ion binding]; other site 426117000497 G-X-G motif; other site 426117000498 Domain of unknown function (DUF336); Region: DUF336; cl01249 426117000499 DsrE/DsrF-like family; Region: DrsE; pfam02635 426117000500 DsrE/DsrF-like family; Region: DrsE; pfam02635 426117000501 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 426117000502 active site 426117000503 metal binding site [ion binding]; metal-binding site 426117000504 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426117000505 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426117000506 Cytochrome c [Energy production and conversion]; Region: COG3258 426117000507 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 426117000508 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 426117000509 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 426117000510 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426117000511 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426117000512 Cytochrome c; Region: Cytochrom_C; pfam00034 426117000513 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426117000514 Moco binding site; other site 426117000515 metal coordination site [ion binding]; other site 426117000516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117000517 dimerization interface [polypeptide binding]; other site 426117000518 putative DNA binding site [nucleotide binding]; other site 426117000519 putative Zn2+ binding site [ion binding]; other site 426117000520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117000521 putative inner membrane protein; Provisional; Region: PRK11099 426117000522 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 426117000523 EF-hand domain pair; Region: EF_hand_5; pfam13499 426117000524 Ca2+ binding site [ion binding]; other site 426117000525 muropeptide transporter; Validated; Region: ampG; cl17669 426117000526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117000527 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 426117000528 Walker A/P-loop; other site 426117000529 ATP binding site [chemical binding]; other site 426117000530 Q-loop/lid; other site 426117000531 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 426117000532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117000533 Walker A/P-loop; other site 426117000534 ATP binding site [chemical binding]; other site 426117000535 Q-loop/lid; other site 426117000536 ABC transporter signature motif; other site 426117000537 Walker B; other site 426117000538 D-loop; other site 426117000539 H-loop/switch region; other site 426117000540 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 426117000541 Thioesterase domain; Region: Thioesterase; pfam00975 426117000542 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117000543 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117000544 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117000545 Walker A/P-loop; other site 426117000546 ATP binding site [chemical binding]; other site 426117000547 Q-loop/lid; other site 426117000548 ABC transporter signature motif; other site 426117000549 Walker B; other site 426117000550 D-loop; other site 426117000551 H-loop/switch region; other site 426117000552 DevC protein; Region: devC; TIGR01185 426117000553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426117000554 FtsX-like permease family; Region: FtsX; pfam02687 426117000555 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 426117000556 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 426117000557 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 426117000558 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426117000559 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 426117000560 active site 426117000561 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426117000562 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426117000563 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 426117000564 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 426117000565 KR domain; Region: KR; pfam08659 426117000566 putative NADP binding site [chemical binding]; other site 426117000567 active site 426117000568 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117000569 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 426117000570 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426117000571 active site 426117000572 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426117000573 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 426117000574 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 426117000575 KR domain; Region: KR; pfam08659 426117000576 putative NADP binding site [chemical binding]; other site 426117000577 active site 426117000578 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117000579 AMP-binding domain protein; Validated; Region: PRK08315 426117000580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117000581 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 426117000582 acyl-activating enzyme (AAE) consensus motif; other site 426117000583 acyl-activating enzyme (AAE) consensus motif; other site 426117000584 putative AMP binding site [chemical binding]; other site 426117000585 putative active site [active] 426117000586 putative CoA binding site [chemical binding]; other site 426117000587 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117000588 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 426117000589 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426117000590 active site 426117000591 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426117000592 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 426117000593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117000594 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 426117000595 Enoylreductase; Region: PKS_ER; smart00829 426117000596 NAD(P) binding site [chemical binding]; other site 426117000597 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 426117000598 KR domain; Region: KR; pfam08659 426117000599 putative NADP binding site [chemical binding]; other site 426117000600 active site 426117000601 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117000602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426117000603 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 426117000604 active site 426117000605 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426117000606 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426117000607 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117000608 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426117000609 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 426117000610 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 426117000611 dimer interface [polypeptide binding]; other site 426117000612 active site 426117000613 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 426117000614 active sites [active] 426117000615 tetramer interface [polypeptide binding]; other site 426117000616 YHS domain; Region: YHS; pfam04945 426117000617 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426117000618 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117000619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117000620 motif II; other site 426117000621 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 426117000622 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 426117000623 DNA binding residues [nucleotide binding] 426117000624 dimer interface [polypeptide binding]; other site 426117000625 copper binding site [ion binding]; other site 426117000626 Domain of unknown function (DUF305); Region: DUF305; cl17794 426117000627 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426117000628 Protein export membrane protein; Region: SecD_SecF; cl14618 426117000629 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 426117000630 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117000631 Response regulator receiver domain; Region: Response_reg; pfam00072 426117000632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000633 active site 426117000634 phosphorylation site [posttranslational modification] 426117000635 intermolecular recognition site; other site 426117000636 dimerization interface [polypeptide binding]; other site 426117000637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117000638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426117000639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117000640 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426117000641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117000642 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426117000643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000644 dimer interface [polypeptide binding]; other site 426117000645 phosphorylation site [posttranslational modification] 426117000646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000647 ATP binding site [chemical binding]; other site 426117000648 Mg2+ binding site [ion binding]; other site 426117000649 G-X-G motif; other site 426117000650 putative transposase OrfB; Reviewed; Region: PHA02517 426117000651 HTH-like domain; Region: HTH_21; pfam13276 426117000652 Integrase core domain; Region: rve; pfam00665 426117000653 Integrase core domain; Region: rve_3; pfam13683 426117000654 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117000655 MULE transposase domain; Region: MULE; pfam10551 426117000656 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426117000657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117000658 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117000659 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117000660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117000661 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 426117000662 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 426117000663 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 426117000664 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 426117000665 TMAO/DMSO reductase; Reviewed; Region: PRK05363 426117000666 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426117000667 Moco binding site; other site 426117000668 metal coordination site [ion binding]; other site 426117000669 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 426117000670 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117000671 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 426117000672 acyl-activating enzyme (AAE) consensus motif; other site 426117000673 putative AMP binding site [chemical binding]; other site 426117000674 putative active site [active] 426117000675 putative CoA binding site [chemical binding]; other site 426117000676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117000677 metal binding site [ion binding]; metal-binding site 426117000678 active site 426117000679 I-site; other site 426117000680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117000681 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 426117000682 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 426117000683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117000684 Walker A motif; other site 426117000685 ATP binding site [chemical binding]; other site 426117000686 Walker B motif; other site 426117000687 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 426117000688 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117000689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117000690 putative active site [active] 426117000691 heme pocket [chemical binding]; other site 426117000692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000693 dimer interface [polypeptide binding]; other site 426117000694 phosphorylation site [posttranslational modification] 426117000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000696 ATP binding site [chemical binding]; other site 426117000697 Mg2+ binding site [ion binding]; other site 426117000698 G-X-G motif; other site 426117000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426117000700 active site 426117000701 phosphorylation site [posttranslational modification] 426117000702 dimerization interface [polypeptide binding]; other site 426117000703 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117000704 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 426117000705 putative NAD(P) binding site [chemical binding]; other site 426117000706 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117000707 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 426117000708 C-terminal domain interface [polypeptide binding]; other site 426117000709 GSH binding site (G-site) [chemical binding]; other site 426117000710 dimer interface [polypeptide binding]; other site 426117000711 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 426117000712 N-terminal domain interface [polypeptide binding]; other site 426117000713 dimer interface [polypeptide binding]; other site 426117000714 substrate binding pocket (H-site) [chemical binding]; other site 426117000715 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 426117000716 TfoX N-terminal domain; Region: TfoX_N; pfam04993 426117000717 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 426117000718 heterodimer interface [polypeptide binding]; other site 426117000719 substrate interaction site [chemical binding]; other site 426117000720 GTP-binding protein LepA; Provisional; Region: PRK05433 426117000721 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 426117000722 G1 box; other site 426117000723 putative GEF interaction site [polypeptide binding]; other site 426117000724 GTP/Mg2+ binding site [chemical binding]; other site 426117000725 Switch I region; other site 426117000726 G2 box; other site 426117000727 G3 box; other site 426117000728 Switch II region; other site 426117000729 G4 box; other site 426117000730 G5 box; other site 426117000731 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 426117000732 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 426117000733 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 426117000734 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117000735 FAD dependent oxidoreductase; Region: DAO; pfam01266 426117000736 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 426117000737 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 426117000738 active site 426117000739 substrate-binding site [chemical binding]; other site 426117000740 metal-binding site [ion binding] 426117000741 ATP binding site [chemical binding]; other site 426117000742 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 426117000743 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 426117000744 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 426117000745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117000746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000747 active site 426117000748 phosphorylation site [posttranslational modification] 426117000749 intermolecular recognition site; other site 426117000750 dimerization interface [polypeptide binding]; other site 426117000751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117000752 DNA binding site [nucleotide binding] 426117000753 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 426117000754 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 426117000755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117000756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117000757 dimerization interface [polypeptide binding]; other site 426117000758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000759 dimer interface [polypeptide binding]; other site 426117000760 phosphorylation site [posttranslational modification] 426117000761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000762 ATP binding site [chemical binding]; other site 426117000763 Mg2+ binding site [ion binding]; other site 426117000764 G-X-G motif; other site 426117000765 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 426117000766 active pocket/dimerization site; other site 426117000767 active site 426117000768 phosphorylation site [posttranslational modification] 426117000769 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 426117000770 regulatory protein interface [polypeptide binding]; other site 426117000771 active site 426117000772 regulatory phosphorylation site [posttranslational modification]; other site 426117000773 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426117000774 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117000775 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426117000776 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 426117000777 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 426117000778 active site 426117000779 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 426117000780 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 426117000781 FAD binding site [chemical binding]; other site 426117000782 substrate binding site [chemical binding]; other site 426117000783 catalytic base [active] 426117000784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117000785 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 426117000786 substrate binding site [chemical binding]; other site 426117000787 oxyanion hole (OAH) forming residues; other site 426117000788 trimer interface [polypeptide binding]; other site 426117000789 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117000790 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117000791 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117000792 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 426117000793 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426117000794 dimer interface [polypeptide binding]; other site 426117000795 active site 426117000796 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 426117000797 classical (c) SDRs; Region: SDR_c; cd05233 426117000798 NAD(P) binding site [chemical binding]; other site 426117000799 active site 426117000800 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117000801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117000802 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 426117000803 acyl-activating enzyme (AAE) consensus motif; other site 426117000804 acyl-activating enzyme (AAE) consensus motif; other site 426117000805 putative AMP binding site [chemical binding]; other site 426117000806 putative active site [active] 426117000807 putative CoA binding site [chemical binding]; other site 426117000808 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 426117000809 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 426117000810 putative valine binding site [chemical binding]; other site 426117000811 dimer interface [polypeptide binding]; other site 426117000812 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 426117000813 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 426117000814 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117000815 PYR/PP interface [polypeptide binding]; other site 426117000816 dimer interface [polypeptide binding]; other site 426117000817 TPP binding site [chemical binding]; other site 426117000818 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117000819 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 426117000820 TPP-binding site [chemical binding]; other site 426117000821 dimer interface [polypeptide binding]; other site 426117000822 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426117000823 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426117000824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117000825 S-adenosylmethionine binding site [chemical binding]; other site 426117000826 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117000827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117000828 dimerization interface [polypeptide binding]; other site 426117000829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117000830 dimer interface [polypeptide binding]; other site 426117000831 putative CheW interface [polypeptide binding]; other site 426117000832 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426117000833 putative binding surface; other site 426117000834 active site 426117000835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000836 ATP binding site [chemical binding]; other site 426117000837 Mg2+ binding site [ion binding]; other site 426117000838 G-X-G motif; other site 426117000839 Response regulator receiver domain; Region: Response_reg; pfam00072 426117000840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000841 active site 426117000842 phosphorylation site [posttranslational modification] 426117000843 intermolecular recognition site; other site 426117000844 dimerization interface [polypeptide binding]; other site 426117000845 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426117000846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000847 active site 426117000848 phosphorylation site [posttranslational modification] 426117000849 intermolecular recognition site; other site 426117000850 dimerization interface [polypeptide binding]; other site 426117000851 CheB methylesterase; Region: CheB_methylest; pfam01339 426117000852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117000853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000854 active site 426117000855 phosphorylation site [posttranslational modification] 426117000856 intermolecular recognition site; other site 426117000857 dimerization interface [polypeptide binding]; other site 426117000858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117000859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000860 dimer interface [polypeptide binding]; other site 426117000861 phosphorylation site [posttranslational modification] 426117000862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000863 ATP binding site [chemical binding]; other site 426117000864 Mg2+ binding site [ion binding]; other site 426117000865 G-X-G motif; other site 426117000866 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 426117000867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000868 active site 426117000869 phosphorylation site [posttranslational modification] 426117000870 intermolecular recognition site; other site 426117000871 dimerization interface [polypeptide binding]; other site 426117000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000873 dimer interface [polypeptide binding]; other site 426117000874 phosphorylation site [posttranslational modification] 426117000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000876 ATP binding site [chemical binding]; other site 426117000877 Mg2+ binding site [ion binding]; other site 426117000878 G-X-G motif; other site 426117000879 Response regulator receiver domain; Region: Response_reg; pfam00072 426117000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000881 active site 426117000882 phosphorylation site [posttranslational modification] 426117000883 intermolecular recognition site; other site 426117000884 dimerization interface [polypeptide binding]; other site 426117000885 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 426117000886 ligand-binding site [chemical binding]; other site 426117000887 methionine gamma-lyase; Validated; Region: PRK07049 426117000888 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426117000889 homodimer interface [polypeptide binding]; other site 426117000890 substrate-cofactor binding pocket; other site 426117000891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117000892 catalytic residue [active] 426117000893 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426117000894 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426117000895 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 426117000896 TrkA-N domain; Region: TrkA_N; pfam02254 426117000897 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 426117000898 AAA domain; Region: AAA_30; pfam13604 426117000899 Family description; Region: UvrD_C_2; pfam13538 426117000900 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 426117000901 active site 426117000902 HslU subunit interaction site [polypeptide binding]; other site 426117000903 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 426117000904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117000905 Walker A motif; other site 426117000906 ATP binding site [chemical binding]; other site 426117000907 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 426117000908 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426117000909 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 426117000910 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 426117000911 Mg++ binding site [ion binding]; other site 426117000912 putative catalytic motif [active] 426117000913 putative substrate binding site [chemical binding]; other site 426117000914 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 426117000915 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426117000916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426117000917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426117000918 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 426117000919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426117000920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426117000921 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 426117000922 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 426117000923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426117000924 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 426117000925 MraW methylase family; Region: Methyltransf_5; cl17771 426117000926 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 426117000927 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 426117000928 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 426117000929 dimer interface [polypeptide binding]; other site 426117000930 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117000931 active site 426117000932 metal binding site [ion binding]; metal-binding site 426117000933 glutathione binding site [chemical binding]; other site 426117000934 aminopeptidase N; Provisional; Region: pepN; PRK14015 426117000935 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 426117000936 Zn binding site [ion binding]; other site 426117000937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117000938 PAS fold; Region: PAS_3; pfam08447 426117000939 putative active site [active] 426117000940 heme pocket [chemical binding]; other site 426117000941 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426117000942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000943 dimer interface [polypeptide binding]; other site 426117000944 phosphorylation site [posttranslational modification] 426117000945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000946 ATP binding site [chemical binding]; other site 426117000947 Mg2+ binding site [ion binding]; other site 426117000948 G-X-G motif; other site 426117000949 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 426117000950 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426117000951 metal binding triad; other site 426117000952 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 426117000953 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426117000954 metal binding triad; other site 426117000955 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 426117000956 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117000957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117000958 putative DNA binding site [nucleotide binding]; other site 426117000959 putative Zn2+ binding site [ion binding]; other site 426117000960 AsnC family; Region: AsnC_trans_reg; pfam01037 426117000961 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 426117000962 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 426117000963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117000964 catalytic residue [active] 426117000965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117000966 dimer interface [polypeptide binding]; other site 426117000967 putative CheW interface [polypeptide binding]; other site 426117000968 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426117000969 active site residue [active] 426117000970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117000971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117000972 dimer interface [polypeptide binding]; other site 426117000973 phosphorylation site [posttranslational modification] 426117000974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117000975 ATP binding site [chemical binding]; other site 426117000976 Mg2+ binding site [ion binding]; other site 426117000977 G-X-G motif; other site 426117000978 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117000979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000980 active site 426117000981 phosphorylation site [posttranslational modification] 426117000982 intermolecular recognition site; other site 426117000983 dimerization interface [polypeptide binding]; other site 426117000984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117000985 DNA binding site [nucleotide binding] 426117000986 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117000987 Response regulator receiver domain; Region: Response_reg; pfam00072 426117000988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117000989 active site 426117000990 phosphorylation site [posttranslational modification] 426117000991 intermolecular recognition site; other site 426117000992 dimerization interface [polypeptide binding]; other site 426117000993 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117000994 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117000995 ligand binding site [chemical binding]; other site 426117000996 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 426117000997 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 426117000998 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 426117000999 Ligand Binding Site [chemical binding]; other site 426117001000 FtsH Extracellular; Region: FtsH_ext; pfam06480 426117001001 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 426117001002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117001003 Walker A motif; other site 426117001004 ATP binding site [chemical binding]; other site 426117001005 Walker B motif; other site 426117001006 arginine finger; other site 426117001007 Peptidase family M41; Region: Peptidase_M41; pfam01434 426117001008 septum formation inhibitor; Reviewed; Region: minC; PRK05177 426117001009 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 426117001010 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 426117001011 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 426117001012 Switch I; other site 426117001013 Switch II; other site 426117001014 Septum formation topological specificity factor MinE; Region: MinE; cl00538 426117001015 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 426117001016 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 426117001017 Nucleoside recognition; Region: Gate; pfam07670 426117001018 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 426117001019 Caspase domain; Region: Peptidase_C14; pfam00656 426117001020 recombinase A; Provisional; Region: recA; PRK09354 426117001021 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 426117001022 hexamer interface [polypeptide binding]; other site 426117001023 Walker A motif; other site 426117001024 ATP binding site [chemical binding]; other site 426117001025 Walker B motif; other site 426117001026 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117001027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117001028 catalytic loop [active] 426117001029 iron binding site [ion binding]; other site 426117001030 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117001031 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426117001032 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426117001033 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117001034 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117001035 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117001036 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 426117001037 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 426117001038 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426117001039 Transcriptional regulator; Region: Transcrip_reg; cl00361 426117001040 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426117001041 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426117001042 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426117001043 TSCPD domain; Region: TSCPD; pfam12637 426117001044 NADH dehydrogenase; Validated; Region: PRK08183 426117001045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 426117001046 Response regulator receiver domain; Region: Response_reg; pfam00072 426117001047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117001048 active site 426117001049 phosphorylation site [posttranslational modification] 426117001050 intermolecular recognition site; other site 426117001051 dimerization interface [polypeptide binding]; other site 426117001052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117001053 Histidine kinase; Region: HisKA_2; pfam07568 426117001054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117001055 ATP binding site [chemical binding]; other site 426117001056 Mg2+ binding site [ion binding]; other site 426117001057 G-X-G motif; other site 426117001058 Response regulator receiver domain; Region: Response_reg; pfam00072 426117001059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117001060 active site 426117001061 phosphorylation site [posttranslational modification] 426117001062 intermolecular recognition site; other site 426117001063 dimerization interface [polypeptide binding]; other site 426117001064 CHASE domain; Region: CHASE; pfam03924 426117001065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117001066 GAF domain; Region: GAF; pfam01590 426117001067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117001068 putative active site [active] 426117001069 PAS fold; Region: PAS_3; pfam08447 426117001070 heme pocket [chemical binding]; other site 426117001071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117001072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117001073 dimer interface [polypeptide binding]; other site 426117001074 phosphorylation site [posttranslational modification] 426117001075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117001076 ATP binding site [chemical binding]; other site 426117001077 Mg2+ binding site [ion binding]; other site 426117001078 G-X-G motif; other site 426117001079 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 426117001080 SapC; Region: SapC; pfam07277 426117001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426117001082 binding surface 426117001083 TPR motif; other site 426117001084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001085 binding surface 426117001086 TPR motif; other site 426117001087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117001088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 426117001089 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 426117001090 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426117001091 4Fe-4S binding domain; Region: Fer4; cl02805 426117001092 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 426117001093 Predicted transporter component [General function prediction only]; Region: COG2391 426117001094 Predicted transporter component [General function prediction only]; Region: COG2391 426117001095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117001096 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 426117001097 Probable Catalytic site; other site 426117001098 metal-binding site 426117001099 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117001100 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426117001101 Probable Catalytic site; other site 426117001102 metal-binding site 426117001103 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117001104 AsnC family; Region: AsnC_trans_reg; pfam01037 426117001105 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 426117001106 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426117001107 active site 426117001108 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426117001109 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 426117001110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117001111 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 426117001112 Enoylreductase; Region: PKS_ER; smart00829 426117001113 NAD(P) binding site [chemical binding]; other site 426117001114 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 426117001115 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 426117001116 putative NADP binding site [chemical binding]; other site 426117001117 active site 426117001118 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 426117001119 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426117001120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117001121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117001122 catalytic residue [active] 426117001123 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 426117001124 active site 426117001125 cosubstrate binding site; other site 426117001126 substrate binding site [chemical binding]; other site 426117001127 catalytic site [active] 426117001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117001129 NAD(P) binding site [chemical binding]; other site 426117001130 active site 426117001131 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 426117001132 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 426117001133 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 426117001134 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 426117001135 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 426117001136 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117001137 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426117001138 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426117001139 NAD binding site [chemical binding]; other site 426117001140 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117001141 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 426117001142 dimerization interface [polypeptide binding]; other site 426117001143 ligand binding site [chemical binding]; other site 426117001144 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 426117001145 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117001146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117001147 catalytic residue [active] 426117001148 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 426117001149 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 426117001150 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 426117001151 alphaNTD - beta interaction site [polypeptide binding]; other site 426117001152 alphaNTD homodimer interface [polypeptide binding]; other site 426117001153 alphaNTD - beta' interaction site [polypeptide binding]; other site 426117001154 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 426117001155 30S ribosomal protein S11; Validated; Region: PRK05309 426117001156 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 426117001157 30S ribosomal protein S13; Region: bact_S13; TIGR03631 426117001158 adenylate kinase; Reviewed; Region: adk; PRK00279 426117001159 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 426117001160 AMP-binding site [chemical binding]; other site 426117001161 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 426117001162 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 426117001163 SecY translocase; Region: SecY; pfam00344 426117001164 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 426117001165 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 426117001166 23S rRNA binding site [nucleotide binding]; other site 426117001167 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 426117001168 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 426117001169 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 426117001170 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 426117001171 5S rRNA interface [nucleotide binding]; other site 426117001172 23S rRNA interface [nucleotide binding]; other site 426117001173 L5 interface [polypeptide binding]; other site 426117001174 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 426117001175 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426117001176 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426117001177 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 426117001178 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 426117001179 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 426117001180 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 426117001181 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 426117001182 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 426117001183 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 426117001184 RNA binding site [nucleotide binding]; other site 426117001185 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 426117001186 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 426117001187 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 426117001188 23S rRNA interface [nucleotide binding]; other site 426117001189 putative translocon interaction site; other site 426117001190 signal recognition particle (SRP54) interaction site; other site 426117001191 L23 interface [polypeptide binding]; other site 426117001192 trigger factor interaction site; other site 426117001193 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 426117001194 23S rRNA interface [nucleotide binding]; other site 426117001195 5S rRNA interface [nucleotide binding]; other site 426117001196 putative antibiotic binding site [chemical binding]; other site 426117001197 L25 interface [polypeptide binding]; other site 426117001198 L27 interface [polypeptide binding]; other site 426117001199 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 426117001200 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 426117001201 G-X-X-G motif; other site 426117001202 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 426117001203 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 426117001204 putative translocon binding site; other site 426117001205 protein-rRNA interface [nucleotide binding]; other site 426117001206 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 426117001207 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 426117001208 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 426117001209 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 426117001210 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 426117001211 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 426117001212 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 426117001213 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 426117001214 elongation factor Tu; Reviewed; Region: PRK00049 426117001215 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 426117001216 G1 box; other site 426117001217 GEF interaction site [polypeptide binding]; other site 426117001218 GTP/Mg2+ binding site [chemical binding]; other site 426117001219 Switch I region; other site 426117001220 G2 box; other site 426117001221 G3 box; other site 426117001222 Switch II region; other site 426117001223 G4 box; other site 426117001224 G5 box; other site 426117001225 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 426117001226 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 426117001227 Antibiotic Binding Site [chemical binding]; other site 426117001228 elongation factor G; Reviewed; Region: PRK00007 426117001229 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 426117001230 G1 box; other site 426117001231 putative GEF interaction site [polypeptide binding]; other site 426117001232 GTP/Mg2+ binding site [chemical binding]; other site 426117001233 Switch I region; other site 426117001234 G2 box; other site 426117001235 G3 box; other site 426117001236 Switch II region; other site 426117001237 G4 box; other site 426117001238 G5 box; other site 426117001239 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 426117001240 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 426117001241 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 426117001242 30S ribosomal protein S7; Validated; Region: PRK05302 426117001243 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 426117001244 S17 interaction site [polypeptide binding]; other site 426117001245 S8 interaction site; other site 426117001246 16S rRNA interaction site [nucleotide binding]; other site 426117001247 streptomycin interaction site [chemical binding]; other site 426117001248 23S rRNA interaction site [nucleotide binding]; other site 426117001249 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 426117001250 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 426117001251 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 426117001252 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 426117001253 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 426117001254 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 426117001255 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 426117001256 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 426117001257 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 426117001258 DNA binding site [nucleotide binding] 426117001259 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 426117001260 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 426117001261 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 426117001262 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 426117001263 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426117001264 RPB11 interaction site [polypeptide binding]; other site 426117001265 RPB12 interaction site [polypeptide binding]; other site 426117001266 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426117001267 RPB3 interaction site [polypeptide binding]; other site 426117001268 RPB1 interaction site [polypeptide binding]; other site 426117001269 RPB11 interaction site [polypeptide binding]; other site 426117001270 RPB10 interaction site [polypeptide binding]; other site 426117001271 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 426117001272 L11 interface [polypeptide binding]; other site 426117001273 putative EF-Tu interaction site [polypeptide binding]; other site 426117001274 putative EF-G interaction site [polypeptide binding]; other site 426117001275 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 426117001276 23S rRNA interface [nucleotide binding]; other site 426117001277 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 426117001278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117001279 dimerization interface [polypeptide binding]; other site 426117001280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117001281 dimer interface [polypeptide binding]; other site 426117001282 putative CheW interface [polypeptide binding]; other site 426117001283 B12 binding domain; Region: B12-binding; pfam02310 426117001284 B12 binding site [chemical binding]; other site 426117001285 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 426117001286 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 426117001287 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 426117001288 mRNA/rRNA interface [nucleotide binding]; other site 426117001289 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 426117001290 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 426117001291 23S rRNA interface [nucleotide binding]; other site 426117001292 L7/L12 interface [polypeptide binding]; other site 426117001293 putative thiostrepton binding site; other site 426117001294 L25 interface [polypeptide binding]; other site 426117001295 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 426117001296 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 426117001297 putative homodimer interface [polypeptide binding]; other site 426117001298 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 426117001299 heterodimer interface [polypeptide binding]; other site 426117001300 homodimer interface [polypeptide binding]; other site 426117001301 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 426117001302 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426117001303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117001304 dimerization interface [polypeptide binding]; other site 426117001305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117001306 dimer interface [polypeptide binding]; other site 426117001307 putative CheW interface [polypeptide binding]; other site 426117001308 elongation factor Tu; Reviewed; Region: PRK00049 426117001309 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 426117001310 G1 box; other site 426117001311 GEF interaction site [polypeptide binding]; other site 426117001312 GTP/Mg2+ binding site [chemical binding]; other site 426117001313 Switch I region; other site 426117001314 G2 box; other site 426117001315 G3 box; other site 426117001316 Switch II region; other site 426117001317 G4 box; other site 426117001318 G5 box; other site 426117001319 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 426117001320 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 426117001321 Antibiotic Binding Site [chemical binding]; other site 426117001322 Acylphosphatase; Region: Acylphosphatase; pfam00708 426117001323 Protein of unknown function, DUF599; Region: DUF599; pfam04654 426117001324 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 426117001325 hypothetical protein; Validated; Region: PRK08245 426117001326 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 426117001327 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117001328 putative C-terminal domain interface [polypeptide binding]; other site 426117001329 putative GSH binding site (G-site) [chemical binding]; other site 426117001330 putative dimer interface [polypeptide binding]; other site 426117001331 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426117001332 N-terminal domain interface [polypeptide binding]; other site 426117001333 dimer interface [polypeptide binding]; other site 426117001334 substrate binding pocket (H-site) [chemical binding]; other site 426117001335 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 426117001336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117001337 FeS/SAM binding site; other site 426117001338 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 426117001339 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 426117001340 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117001341 motif 1; other site 426117001342 dimer interface [polypeptide binding]; other site 426117001343 active site 426117001344 motif 2; other site 426117001345 motif 3; other site 426117001346 elongation factor P; Validated; Region: PRK00529 426117001347 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 426117001348 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 426117001349 RNA binding site [nucleotide binding]; other site 426117001350 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 426117001351 RNA binding site [nucleotide binding]; other site 426117001352 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 426117001353 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 426117001354 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117001355 DNA-binding site [nucleotide binding]; DNA binding site 426117001356 RNA-binding motif; other site 426117001357 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117001358 DNA-binding site [nucleotide binding]; DNA binding site 426117001359 RNA-binding motif; other site 426117001360 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 426117001361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426117001362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117001363 dimer interface [polypeptide binding]; other site 426117001364 putative CheW interface [polypeptide binding]; other site 426117001365 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 426117001366 putative active site pocket [active] 426117001367 dimerization interface [polypeptide binding]; other site 426117001368 putative catalytic residue [active] 426117001369 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 426117001370 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426117001371 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426117001372 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426117001373 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426117001374 carboxyltransferase (CT) interaction site; other site 426117001375 biotinylation site [posttranslational modification]; other site 426117001376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117001377 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117001378 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426117001379 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 426117001380 putative active site [active] 426117001381 Zn binding site [ion binding]; other site 426117001382 Membrane transport protein; Region: Mem_trans; cl09117 426117001383 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 426117001384 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 426117001385 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 426117001386 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 426117001387 dimerization interface [polypeptide binding]; other site 426117001388 active site 426117001389 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 426117001390 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 426117001391 Tetramer interface [polypeptide binding]; other site 426117001392 active site 426117001393 FMN-binding site [chemical binding]; other site 426117001394 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 426117001395 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 426117001396 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 426117001397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117001398 dimer interface [polypeptide binding]; other site 426117001399 putative CheW interface [polypeptide binding]; other site 426117001400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117001401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117001402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117001403 dimerization interface [polypeptide binding]; other site 426117001404 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426117001405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117001406 substrate binding pocket [chemical binding]; other site 426117001407 membrane-bound complex binding site; other site 426117001408 hinge residues; other site 426117001409 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117001410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117001411 dimer interface [polypeptide binding]; other site 426117001412 conserved gate region; other site 426117001413 putative PBP binding loops; other site 426117001414 ABC-ATPase subunit interface; other site 426117001415 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117001416 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117001417 Walker A/P-loop; other site 426117001418 ATP binding site [chemical binding]; other site 426117001419 Q-loop/lid; other site 426117001420 ABC transporter signature motif; other site 426117001421 Walker B; other site 426117001422 D-loop; other site 426117001423 H-loop/switch region; other site 426117001424 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117001425 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117001426 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117001427 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117001428 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 426117001429 MG2 domain; Region: A2M_N; pfam01835 426117001430 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 426117001431 surface patch; other site 426117001432 thioester region; other site 426117001433 specificity defining residues; other site 426117001434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117001435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117001436 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 426117001437 putative effector binding pocket; other site 426117001438 putative dimerization interface [polypeptide binding]; other site 426117001439 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 426117001440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117001441 active site 426117001442 catalytic tetrad [active] 426117001443 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 426117001444 Transglycosylase; Region: Transgly; pfam00912 426117001445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426117001446 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 426117001447 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 426117001448 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 426117001449 domain interfaces; other site 426117001450 active site 426117001451 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 426117001452 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426117001453 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426117001454 putative dimer interface [polypeptide binding]; other site 426117001455 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 426117001456 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117001457 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 426117001458 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426117001459 active site 426117001460 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117001461 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426117001462 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 426117001463 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 426117001464 active site 426117001465 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 426117001466 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 426117001467 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 426117001468 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 426117001469 putative metal binding site [ion binding]; other site 426117001470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426117001471 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426117001472 ABC-ATPase subunit interface; other site 426117001473 dimer interface [polypeptide binding]; other site 426117001474 putative PBP binding regions; other site 426117001475 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 426117001476 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 426117001477 putative active site [active] 426117001478 catalytic triad [active] 426117001479 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 426117001480 maltose O-acetyltransferase; Provisional; Region: PRK10092 426117001481 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 426117001482 active site 426117001483 substrate binding site [chemical binding]; other site 426117001484 trimer interface [polypeptide binding]; other site 426117001485 CoA binding site [chemical binding]; other site 426117001486 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426117001487 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426117001488 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426117001489 Protein of unknown function (DUF533); Region: DUF533; pfam04391 426117001490 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 426117001491 putative metal binding site [ion binding]; other site 426117001492 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 426117001493 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117001494 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117001495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117001496 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117001497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117001498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117001499 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 426117001500 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 426117001501 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 426117001502 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 426117001503 Imelysin; Region: Peptidase_M75; pfam09375 426117001504 Iron permease FTR1 family; Region: FTR1; cl00475 426117001505 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 426117001506 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 426117001507 Walker A/P-loop; other site 426117001508 ATP binding site [chemical binding]; other site 426117001509 Q-loop/lid; other site 426117001510 ABC transporter signature motif; other site 426117001511 Walker B; other site 426117001512 D-loop; other site 426117001513 H-loop/switch region; other site 426117001514 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 426117001515 Short C-terminal domain; Region: SHOCT; pfam09851 426117001516 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 426117001517 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117001518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117001519 S-adenosylmethionine binding site [chemical binding]; other site 426117001520 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117001521 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426117001522 C-terminal domain interface [polypeptide binding]; other site 426117001523 GSH binding site (G-site) [chemical binding]; other site 426117001524 dimer interface [polypeptide binding]; other site 426117001525 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 426117001526 N-terminal domain interface [polypeptide binding]; other site 426117001527 putative dimer interface [polypeptide binding]; other site 426117001528 active site 426117001529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117001530 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426117001531 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 426117001532 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426117001533 speF leader as predicted by Rfam (RF00518), score 106.03 426117001534 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 426117001535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 426117001536 dimer interface [polypeptide binding]; other site 426117001537 active site 426117001538 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426117001539 catalytic residues [active] 426117001540 substrate binding site [chemical binding]; other site 426117001541 Predicted acetyltransferase [General function prediction only]; Region: COG3153 426117001542 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 426117001543 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 426117001544 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426117001545 putative active site [active] 426117001546 amidase; Provisional; Region: PRK07042 426117001547 Amidase; Region: Amidase; cl11426 426117001548 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 426117001549 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 426117001550 NAD(P) binding site [chemical binding]; other site 426117001551 homodimer interface [polypeptide binding]; other site 426117001552 substrate binding site [chemical binding]; other site 426117001553 active site 426117001554 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 426117001555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 426117001556 CreA protein; Region: CreA; pfam05981 426117001557 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 426117001558 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426117001559 active site 426117001560 HIGH motif; other site 426117001561 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426117001562 KMSKS motif; other site 426117001563 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 426117001564 tRNA binding surface [nucleotide binding]; other site 426117001565 anticodon binding site; other site 426117001566 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 426117001567 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426117001568 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426117001569 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117001570 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117001571 Walker A/P-loop; other site 426117001572 ATP binding site [chemical binding]; other site 426117001573 Q-loop/lid; other site 426117001574 ABC transporter signature motif; other site 426117001575 Walker B; other site 426117001576 D-loop; other site 426117001577 H-loop/switch region; other site 426117001578 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117001580 dimer interface [polypeptide binding]; other site 426117001581 conserved gate region; other site 426117001582 putative PBP binding loops; other site 426117001583 ABC-ATPase subunit interface; other site 426117001584 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117001585 NMT1-like family; Region: NMT1_2; pfam13379 426117001586 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117001587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117001588 DNA-binding site [nucleotide binding]; DNA binding site 426117001589 FCD domain; Region: FCD; pfam07729 426117001590 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426117001591 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 426117001592 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 426117001593 trimer interface [polypeptide binding]; other site 426117001594 putative metal binding site [ion binding]; other site 426117001595 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 426117001596 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 426117001597 catalytic residue [active] 426117001598 putative FPP diphosphate binding site; other site 426117001599 putative FPP binding hydrophobic cleft; other site 426117001600 dimer interface [polypeptide binding]; other site 426117001601 putative IPP diphosphate binding site; other site 426117001602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117001603 putative DNA binding site [nucleotide binding]; other site 426117001604 dimerization interface [polypeptide binding]; other site 426117001605 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117001606 putative Zn2+ binding site [ion binding]; other site 426117001607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117001608 dimer interface [polypeptide binding]; other site 426117001609 phosphorylation site [posttranslational modification] 426117001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117001611 ATP binding site [chemical binding]; other site 426117001612 Mg2+ binding site [ion binding]; other site 426117001613 G-X-G motif; other site 426117001614 Response regulator receiver domain; Region: Response_reg; pfam00072 426117001615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117001616 active site 426117001617 phosphorylation site [posttranslational modification] 426117001618 intermolecular recognition site; other site 426117001619 dimerization interface [polypeptide binding]; other site 426117001620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426117001621 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117001622 catalytic residues [active] 426117001623 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 426117001624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426117001625 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 426117001626 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426117001627 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 426117001628 substrate binding site [chemical binding]; other site 426117001629 active site 426117001630 catalytic residues [active] 426117001631 heterodimer interface [polypeptide binding]; other site 426117001632 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117001633 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 426117001634 Walker A/P-loop; other site 426117001635 ATP binding site [chemical binding]; other site 426117001636 Q-loop/lid; other site 426117001637 ABC transporter signature motif; other site 426117001638 Walker B; other site 426117001639 D-loop; other site 426117001640 H-loop/switch region; other site 426117001641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117001642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117001643 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426117001644 catalytic triad [active] 426117001645 Isochorismatase family; Region: Isochorismatase; pfam00857 426117001646 conserved cis-peptide bond; other site 426117001647 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117001648 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 426117001649 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 426117001650 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 426117001651 primosome assembly protein PriA; Validated; Region: PRK05580 426117001652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117001653 ATP binding site [chemical binding]; other site 426117001654 putative Mg++ binding site [ion binding]; other site 426117001655 helicase superfamily c-terminal domain; Region: HELICc; smart00490 426117001656 nucleotide binding region [chemical binding]; other site 426117001657 ATP-binding site [chemical binding]; other site 426117001658 Uncharacterized conserved protein [Function unknown]; Region: COG2835 426117001659 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 426117001660 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426117001661 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 426117001662 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 426117001663 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426117001664 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 426117001665 Substrate binding site; other site 426117001666 metal-binding site 426117001667 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 426117001668 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 426117001669 Phosphotransferase enzyme family; Region: APH; pfam01636 426117001670 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 426117001671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117001672 active site 426117001673 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 426117001674 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 426117001675 dimer interface [polypeptide binding]; other site 426117001676 active site 426117001677 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 426117001678 dimer interface [polypeptide binding]; other site 426117001679 active site 426117001680 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 426117001681 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 426117001682 putative active site [active] 426117001683 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426117001684 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117001685 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 426117001686 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 426117001687 homotetramer interface [polypeptide binding]; other site 426117001688 ligand binding site [chemical binding]; other site 426117001689 catalytic site [active] 426117001690 NAD binding site [chemical binding]; other site 426117001691 PAS fold; Region: PAS_7; pfam12860 426117001692 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117001693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117001694 dimer interface [polypeptide binding]; other site 426117001695 phosphorylation site [posttranslational modification] 426117001696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117001697 ATP binding site [chemical binding]; other site 426117001698 Mg2+ binding site [ion binding]; other site 426117001699 G-X-G motif; other site 426117001700 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 426117001701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117001702 ATP binding site [chemical binding]; other site 426117001703 putative Mg++ binding site [ion binding]; other site 426117001704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117001705 nucleotide binding region [chemical binding]; other site 426117001706 ATP-binding site [chemical binding]; other site 426117001707 TRCF domain; Region: TRCF; pfam03461 426117001708 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 426117001709 transmembrane helices; other site 426117001710 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426117001711 TrkA-C domain; Region: TrkA_C; pfam02080 426117001712 TrkA-C domain; Region: TrkA_C; pfam02080 426117001713 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 426117001714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117001715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117001716 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 426117001717 putative substrate binding pocket [chemical binding]; other site 426117001718 putative dimerization interface [polypeptide binding]; other site 426117001719 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 426117001720 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426117001721 TolR protein; Region: tolR; TIGR02801 426117001722 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 426117001723 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 426117001724 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426117001725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426117001726 DNA binding site [nucleotide binding] 426117001727 domain linker motif; other site 426117001728 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 426117001729 ligand binding site [chemical binding]; other site 426117001730 dimerization interface [polypeptide binding]; other site 426117001731 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 426117001732 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426117001733 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 426117001734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426117001735 potassium uptake protein; Region: kup; TIGR00794 426117001736 K+ potassium transporter; Region: K_trans; pfam02705 426117001737 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117001738 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426117001739 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426117001740 dimer interface [polypeptide binding]; other site 426117001741 ADP-ribose binding site [chemical binding]; other site 426117001742 active site 426117001743 nudix motif; other site 426117001744 metal binding site [ion binding]; metal-binding site 426117001745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 426117001746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117001747 dimerization interface [polypeptide binding]; other site 426117001748 putative DNA binding site [nucleotide binding]; other site 426117001749 putative Zn2+ binding site [ion binding]; other site 426117001750 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 426117001751 Sodium Bile acid symporter family; Region: SBF; cl17470 426117001752 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 426117001753 ArsC family; Region: ArsC; pfam03960 426117001754 catalytic residues [active] 426117001755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117001756 putative DNA binding site [nucleotide binding]; other site 426117001757 putative Zn2+ binding site [ion binding]; other site 426117001758 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426117001759 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117001760 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117001761 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117001762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117001763 dimerization interface [polypeptide binding]; other site 426117001764 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117001765 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117001766 dimer interface [polypeptide binding]; other site 426117001767 putative CheW interface [polypeptide binding]; other site 426117001768 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117001769 cyclase homology domain; Region: CHD; cd07302 426117001770 nucleotidyl binding site; other site 426117001771 metal binding site [ion binding]; metal-binding site 426117001772 dimer interface [polypeptide binding]; other site 426117001773 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117001774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001775 TPR motif; other site 426117001776 binding surface 426117001777 TPR repeat; Region: TPR_11; pfam13414 426117001778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001779 TPR motif; other site 426117001780 binding surface 426117001781 benzoate transport; Region: 2A0115; TIGR00895 426117001782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117001783 putative substrate translocation pore; other site 426117001784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117001785 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 426117001786 NAD(P) binding site [chemical binding]; other site 426117001787 catalytic residues [active] 426117001788 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117001789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117001790 DNA-binding site [nucleotide binding]; DNA binding site 426117001791 FCD domain; Region: FCD; pfam07729 426117001792 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 426117001793 TAP-like protein; Region: Abhydrolase_4; pfam08386 426117001794 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 426117001795 cyclase homology domain; Region: CHD; cd07302 426117001796 nucleotidyl binding site; other site 426117001797 metal binding site [ion binding]; metal-binding site 426117001798 dimer interface [polypeptide binding]; other site 426117001799 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117001800 cyclase homology domain; Region: CHD; cd07302 426117001801 nucleotidyl binding site; other site 426117001802 metal binding site [ion binding]; metal-binding site 426117001803 dimer interface [polypeptide binding]; other site 426117001804 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117001805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001806 TPR motif; other site 426117001807 binding surface 426117001808 TPR repeat; Region: TPR_11; pfam13414 426117001809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001810 TPR motif; other site 426117001811 binding surface 426117001812 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 426117001813 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 426117001814 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 426117001815 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426117001816 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426117001817 TPR repeat; Region: TPR_11; pfam13414 426117001818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001819 binding surface 426117001820 TPR motif; other site 426117001821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001822 binding surface 426117001823 TPR repeat; Region: TPR_11; pfam13414 426117001824 TPR motif; other site 426117001825 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 426117001826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001827 binding surface 426117001828 TPR motif; other site 426117001829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001830 binding surface 426117001831 TPR motif; other site 426117001832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001833 binding surface 426117001834 TPR motif; other site 426117001835 TPR repeat; Region: TPR_11; pfam13414 426117001836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001837 binding surface 426117001838 TPR motif; other site 426117001839 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 426117001840 Tetratricopeptide repeat; Region: TPR_1; pfam00515 426117001841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001842 binding surface 426117001843 TPR motif; other site 426117001844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117001845 binding surface 426117001846 TPR motif; other site 426117001847 TPR repeat; Region: TPR_11; pfam13414 426117001848 Caspase domain; Region: Peptidase_C14; pfam00656 426117001849 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 426117001850 flagellin; Reviewed; Region: PRK12688 426117001851 flagellin; Reviewed; Region: PRK12688 426117001852 Flagellar protein FlbT; Region: FlbT; cl11455 426117001853 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117001854 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117001855 Walker A/P-loop; other site 426117001856 ATP binding site [chemical binding]; other site 426117001857 Q-loop/lid; other site 426117001858 ABC transporter signature motif; other site 426117001859 Walker B; other site 426117001860 D-loop; other site 426117001861 H-loop/switch region; other site 426117001862 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117001863 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117001864 Walker A/P-loop; other site 426117001865 ATP binding site [chemical binding]; other site 426117001866 Q-loop/lid; other site 426117001867 ABC transporter signature motif; other site 426117001868 Walker B; other site 426117001869 D-loop; other site 426117001870 H-loop/switch region; other site 426117001871 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117001872 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117001873 TM-ABC transporter signature motif; other site 426117001874 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117001875 TM-ABC transporter signature motif; other site 426117001876 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117001877 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117001878 putative ligand binding site [chemical binding]; other site 426117001879 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117001880 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117001881 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117001882 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117001883 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117001884 catalytic loop [active] 426117001885 iron binding site [ion binding]; other site 426117001886 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117001887 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426117001888 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 426117001889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117001890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117001891 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426117001892 Amidase; Region: Amidase; cl11426 426117001893 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 426117001894 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117001895 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117001896 dihydroorotase; Provisional; Region: PRK09237 426117001897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117001898 active site 426117001899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117001900 S-adenosylmethionine binding site [chemical binding]; other site 426117001901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117001902 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 426117001903 DctM-like transporters; Region: DctM; pfam06808 426117001904 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 426117001905 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117001906 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117001907 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426117001908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117001909 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426117001910 dimerization interface [polypeptide binding]; other site 426117001911 substrate binding pocket [chemical binding]; other site 426117001912 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 426117001913 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426117001914 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 426117001915 Uncharacterized conserved protein [Function unknown]; Region: COG1359 426117001916 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117001917 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117001918 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 426117001919 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 426117001920 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 426117001921 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117001922 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117001923 Integrase core domain; Region: rve; pfam00665 426117001924 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117001925 Response regulator receiver domain; Region: Response_reg; pfam00072 426117001926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117001927 active site 426117001928 phosphorylation site [posttranslational modification] 426117001929 intermolecular recognition site; other site 426117001930 dimerization interface [polypeptide binding]; other site 426117001931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117001932 DNA binding residues [nucleotide binding] 426117001933 dimerization interface [polypeptide binding]; other site 426117001934 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 426117001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117001936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117001937 dimer interface [polypeptide binding]; other site 426117001938 phosphorylation site [posttranslational modification] 426117001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117001940 ATP binding site [chemical binding]; other site 426117001941 Mg2+ binding site [ion binding]; other site 426117001942 G-X-G motif; other site 426117001943 Response regulator receiver domain; Region: Response_reg; pfam00072 426117001944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117001945 active site 426117001946 phosphorylation site [posttranslational modification] 426117001947 intermolecular recognition site; other site 426117001948 dimerization interface [polypeptide binding]; other site 426117001949 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117001950 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 426117001951 putative ligand binding site [chemical binding]; other site 426117001952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117001953 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117001954 TM-ABC transporter signature motif; other site 426117001955 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117001956 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117001957 TM-ABC transporter signature motif; other site 426117001958 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 426117001959 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117001960 Walker A/P-loop; other site 426117001961 ATP binding site [chemical binding]; other site 426117001962 Q-loop/lid; other site 426117001963 ABC transporter signature motif; other site 426117001964 Walker B; other site 426117001965 D-loop; other site 426117001966 H-loop/switch region; other site 426117001967 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 426117001968 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117001969 Walker A/P-loop; other site 426117001970 ATP binding site [chemical binding]; other site 426117001971 Q-loop/lid; other site 426117001972 ABC transporter signature motif; other site 426117001973 Walker B; other site 426117001974 D-loop; other site 426117001975 H-loop/switch region; other site 426117001976 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 426117001977 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 426117001978 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 426117001979 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 426117001980 multimer interface [polypeptide binding]; other site 426117001981 active site 426117001982 catalytic triad [active] 426117001983 dimer interface [polypeptide binding]; other site 426117001984 MoxR-like ATPases [General function prediction only]; Region: COG0714 426117001985 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 426117001986 Walker A motif; other site 426117001987 ATP binding site [chemical binding]; other site 426117001988 Walker B motif; other site 426117001989 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 426117001990 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426117001991 metal ion-dependent adhesion site (MIDAS); other site 426117001992 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117001993 active site 426117001994 oxyanion hole [active] 426117001995 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 426117001996 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426117001997 CoenzymeA binding site [chemical binding]; other site 426117001998 subunit interaction site [polypeptide binding]; other site 426117001999 PHB binding site; other site 426117002000 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426117002001 heme-binding site [chemical binding]; other site 426117002002 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117002003 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426117002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002005 D-galactonate transporter; Region: 2A0114; TIGR00893 426117002006 putative substrate translocation pore; other site 426117002007 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117002008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117002009 DNA-binding site [nucleotide binding]; DNA binding site 426117002010 NADH(P)-binding; Region: NAD_binding_10; pfam13460 426117002011 extended (e) SDRs; Region: SDR_e; cd08946 426117002012 NAD(P) binding site [chemical binding]; other site 426117002013 active site 426117002014 substrate binding site [chemical binding]; other site 426117002015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117002016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117002017 active site 426117002018 catalytic tetrad [active] 426117002019 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 426117002020 putative active site [active] 426117002021 putative metal binding site [ion binding]; other site 426117002022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117002023 non-specific DNA binding site [nucleotide binding]; other site 426117002024 salt bridge; other site 426117002025 sequence-specific DNA binding site [nucleotide binding]; other site 426117002026 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 426117002027 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 426117002028 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426117002029 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426117002030 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 426117002031 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 426117002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117002033 NAD(P) binding site [chemical binding]; other site 426117002034 active site 426117002035 Predicted transcriptional regulators [Transcription]; Region: COG1733 426117002036 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426117002037 CHASE3 domain; Region: CHASE3; pfam05227 426117002038 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117002039 dimerization interface [polypeptide binding]; other site 426117002040 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117002041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117002042 dimer interface [polypeptide binding]; other site 426117002043 putative CheW interface [polypeptide binding]; other site 426117002044 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 426117002045 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 426117002046 Helix-turn-helix domain; Region: HTH_18; pfam12833 426117002047 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 426117002048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117002049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117002050 DNA binding residues [nucleotide binding] 426117002051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117002052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002053 active site 426117002054 phosphorylation site [posttranslational modification] 426117002055 intermolecular recognition site; other site 426117002056 dimerization interface [polypeptide binding]; other site 426117002057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117002058 DNA binding residues [nucleotide binding] 426117002059 dimerization interface [polypeptide binding]; other site 426117002060 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 426117002061 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426117002062 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 426117002063 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 426117002064 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 426117002065 active site 426117002066 DNA binding site [nucleotide binding] 426117002067 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 426117002068 DNA binding site [nucleotide binding] 426117002069 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 426117002070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117002071 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 426117002072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117002073 S-adenosylmethionine binding site [chemical binding]; other site 426117002074 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 426117002075 putative nucleotide binding site [chemical binding]; other site 426117002076 uridine monophosphate binding site [chemical binding]; other site 426117002077 homohexameric interface [polypeptide binding]; other site 426117002078 ribosome recycling factor; Reviewed; Region: frr; PRK00083 426117002079 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 426117002080 hinge region; other site 426117002081 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 426117002082 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 426117002083 catalytic residue [active] 426117002084 putative FPP diphosphate binding site; other site 426117002085 putative FPP binding hydrophobic cleft; other site 426117002086 dimer interface [polypeptide binding]; other site 426117002087 putative IPP diphosphate binding site; other site 426117002088 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 426117002089 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 426117002090 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117002091 HAMP domain; Region: HAMP; pfam00672 426117002092 dimerization interface [polypeptide binding]; other site 426117002093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117002094 dimer interface [polypeptide binding]; other site 426117002095 putative CheW interface [polypeptide binding]; other site 426117002096 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 426117002097 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 426117002098 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 426117002099 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 426117002100 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 426117002101 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 426117002102 active site 426117002103 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 426117002104 protein binding site [polypeptide binding]; other site 426117002105 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 426117002106 putative substrate binding region [chemical binding]; other site 426117002107 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 426117002108 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426117002109 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426117002110 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426117002111 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426117002112 Surface antigen; Region: Bac_surface_Ag; pfam01103 426117002113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117002114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117002115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117002116 dimerization interface [polypeptide binding]; other site 426117002117 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 426117002118 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426117002119 potential catalytic triad [active] 426117002120 conserved cys residue [active] 426117002121 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 426117002122 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 426117002123 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 426117002124 trimer interface [polypeptide binding]; other site 426117002125 active site 426117002126 UDP-GlcNAc binding site [chemical binding]; other site 426117002127 lipid binding site [chemical binding]; lipid-binding site 426117002128 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 426117002129 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 426117002130 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 426117002131 active site 426117002132 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 426117002133 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 426117002134 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 426117002135 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 426117002136 dimer interface [polypeptide binding]; other site 426117002137 active site 426117002138 citrylCoA binding site [chemical binding]; other site 426117002139 NADH binding [chemical binding]; other site 426117002140 cationic pore residues; other site 426117002141 oxalacetate/citrate binding site [chemical binding]; other site 426117002142 coenzyme A binding site [chemical binding]; other site 426117002143 catalytic triad [active] 426117002144 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 426117002145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117002146 active site 426117002147 HIGH motif; other site 426117002148 nucleotide binding site [chemical binding]; other site 426117002149 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426117002150 active site 426117002151 KMSKS motif; other site 426117002152 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 426117002153 Competence protein; Region: Competence; pfam03772 426117002154 hypothetical protein; Validated; Region: PRK00124 426117002155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117002156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002157 phosphorylation site [posttranslational modification] 426117002158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117002159 DNA binding residues [nucleotide binding] 426117002160 dimerization interface [polypeptide binding]; other site 426117002161 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 426117002162 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426117002163 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426117002164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117002165 GAF domain; Region: GAF; pfam01590 426117002166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117002167 PAS domain; Region: PAS_9; pfam13426 426117002168 putative active site [active] 426117002169 heme pocket [chemical binding]; other site 426117002170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117002171 PAS fold; Region: PAS_3; pfam08447 426117002172 putative active site [active] 426117002173 heme pocket [chemical binding]; other site 426117002174 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 426117002175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117002176 dimer interface [polypeptide binding]; other site 426117002177 phosphorylation site [posttranslational modification] 426117002178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117002179 ATP binding site [chemical binding]; other site 426117002180 Mg2+ binding site [ion binding]; other site 426117002181 G-X-G motif; other site 426117002182 Response regulator receiver domain; Region: Response_reg; pfam00072 426117002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002184 active site 426117002185 phosphorylation site [posttranslational modification] 426117002186 intermolecular recognition site; other site 426117002187 dimerization interface [polypeptide binding]; other site 426117002188 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426117002189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002190 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 426117002191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002192 active site 426117002193 phosphorylation site [posttranslational modification] 426117002194 intermolecular recognition site; other site 426117002195 dimerization interface [polypeptide binding]; other site 426117002196 exopolyphosphatase; Region: exo_poly_only; TIGR03706 426117002197 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 426117002198 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 426117002199 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 426117002200 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 426117002201 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 426117002202 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426117002203 putative ligand binding site [chemical binding]; other site 426117002204 NAD binding site [chemical binding]; other site 426117002205 dimerization interface [polypeptide binding]; other site 426117002206 catalytic site [active] 426117002207 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117002208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117002209 Walker A/P-loop; other site 426117002210 ATP binding site [chemical binding]; other site 426117002211 Q-loop/lid; other site 426117002212 ABC transporter signature motif; other site 426117002213 Walker B; other site 426117002214 D-loop; other site 426117002215 H-loop/switch region; other site 426117002216 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117002217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117002218 Walker A/P-loop; other site 426117002219 ATP binding site [chemical binding]; other site 426117002220 Q-loop/lid; other site 426117002221 ABC transporter signature motif; other site 426117002222 Walker B; other site 426117002223 D-loop; other site 426117002224 H-loop/switch region; other site 426117002225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117002226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117002227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002228 dimer interface [polypeptide binding]; other site 426117002229 conserved gate region; other site 426117002230 ABC-ATPase subunit interface; other site 426117002231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002233 dimer interface [polypeptide binding]; other site 426117002234 conserved gate region; other site 426117002235 putative PBP binding loops; other site 426117002236 ABC-ATPase subunit interface; other site 426117002237 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 426117002238 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117002239 aldolase II superfamily protein; Provisional; Region: PRK07044 426117002240 intersubunit interface [polypeptide binding]; other site 426117002241 active site 426117002242 Zn2+ binding site [ion binding]; other site 426117002243 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117002244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117002245 DNA-binding site [nucleotide binding]; DNA binding site 426117002246 FCD domain; Region: FCD; pfam07729 426117002247 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 426117002248 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426117002249 active site 426117002250 Zn binding site [ion binding]; other site 426117002251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002252 active site 426117002253 phosphorylation site [posttranslational modification] 426117002254 intermolecular recognition site; other site 426117002255 dimerization interface [polypeptide binding]; other site 426117002256 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 426117002257 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 426117002258 putative active site [active] 426117002259 putative dimer interface [polypeptide binding]; other site 426117002260 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426117002261 5'-3' exonuclease; Region: 53EXOc; smart00475 426117002262 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 426117002263 active site 426117002264 metal binding site 1 [ion binding]; metal-binding site 426117002265 putative 5' ssDNA interaction site; other site 426117002266 metal binding site 3; metal-binding site 426117002267 metal binding site 2 [ion binding]; metal-binding site 426117002268 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 426117002269 putative DNA binding site [nucleotide binding]; other site 426117002270 putative metal binding site [ion binding]; other site 426117002271 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 426117002272 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 426117002273 active site 426117002274 catalytic site [active] 426117002275 substrate binding site [chemical binding]; other site 426117002276 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 426117002277 active site 426117002278 DNA binding site [nucleotide binding] 426117002279 catalytic site [active] 426117002280 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 426117002281 B1 nucleotide binding pocket [chemical binding]; other site 426117002282 B2 nucleotide binding pocket [chemical binding]; other site 426117002283 CAS motifs; other site 426117002284 active site 426117002285 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 426117002286 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117002287 putative C-terminal domain interface [polypeptide binding]; other site 426117002288 putative GSH binding site (G-site) [chemical binding]; other site 426117002289 putative dimer interface [polypeptide binding]; other site 426117002290 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 426117002291 putative N-terminal domain interface [polypeptide binding]; other site 426117002292 putative dimer interface [polypeptide binding]; other site 426117002293 putative substrate binding pocket (H-site) [chemical binding]; other site 426117002294 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426117002295 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 426117002296 Cupin domain; Region: Cupin_2; cl17218 426117002297 flagellin; Reviewed; Region: PRK12688 426117002298 flagellin; Reviewed; Region: PRK12688 426117002299 Flagellar protein FlbT; Region: FlbT; cl11455 426117002300 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426117002301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117002302 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 426117002303 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 426117002304 Walker A/P-loop; other site 426117002305 ATP binding site [chemical binding]; other site 426117002306 Q-loop/lid; other site 426117002307 ABC transporter signature motif; other site 426117002308 Walker B; other site 426117002309 D-loop; other site 426117002310 H-loop/switch region; other site 426117002311 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 426117002312 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 426117002313 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 426117002314 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 426117002315 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 426117002316 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 426117002317 Peptidase family M50; Region: Peptidase_M50; pfam02163 426117002318 active site 426117002319 putative substrate binding region [chemical binding]; other site 426117002320 FOG: CBS domain [General function prediction only]; Region: COG0517 426117002321 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 426117002322 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117002323 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117002324 ligand binding site [chemical binding]; other site 426117002325 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 426117002326 SmpB-tmRNA interface; other site 426117002327 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426117002328 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 426117002329 dimer interface [polypeptide binding]; other site 426117002330 active site 426117002331 catalytic residue [active] 426117002332 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117002333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117002334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117002335 catalytic residue [active] 426117002336 Domain of unknown function DUF77; Region: DUF77; pfam01910 426117002337 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 426117002338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117002339 binding surface 426117002340 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 426117002341 TPR motif; other site 426117002342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117002343 TPR motif; other site 426117002344 binding surface 426117002345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117002346 Porin subfamily; Region: Porin_2; pfam02530 426117002347 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426117002348 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117002349 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117002350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117002351 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 426117002352 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 426117002353 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426117002354 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426117002355 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 426117002356 DNA methylase; Region: N6_N4_Mtase; pfam01555 426117002357 Response regulator receiver domain; Region: Response_reg; pfam00072 426117002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002359 active site 426117002360 phosphorylation site [posttranslational modification] 426117002361 intermolecular recognition site; other site 426117002362 dimerization interface [polypeptide binding]; other site 426117002363 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426117002364 CsbD-like; Region: CsbD; pfam05532 426117002365 FecR protein; Region: FecR; pfam04773 426117002366 CHASE2 domain; Region: CHASE2; pfam05226 426117002367 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117002368 cyclase homology domain; Region: CHD; cd07302 426117002369 nucleotidyl binding site; other site 426117002370 metal binding site [ion binding]; metal-binding site 426117002371 dimer interface [polypeptide binding]; other site 426117002372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117002373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117002374 ligand binding site [chemical binding]; other site 426117002375 flexible hinge region; other site 426117002376 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 426117002377 non-specific DNA interactions [nucleotide binding]; other site 426117002378 DNA binding site [nucleotide binding] 426117002379 sequence specific DNA binding site [nucleotide binding]; other site 426117002380 putative cAMP binding site [chemical binding]; other site 426117002381 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117002382 benzoate transport; Region: 2A0115; TIGR00895 426117002383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002384 putative substrate translocation pore; other site 426117002385 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 426117002386 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 426117002387 active site 426117002388 catalytic residues [active] 426117002389 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 426117002390 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 426117002391 putative heme binding pocket [chemical binding]; other site 426117002392 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 426117002393 dimerization interface [polypeptide binding]; other site 426117002394 metal binding site [ion binding]; metal-binding site 426117002395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117002396 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 426117002397 putative substrate binding site [chemical binding]; other site 426117002398 putative ATP binding site [chemical binding]; other site 426117002399 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117002400 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 426117002401 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117002402 PilZ domain; Region: PilZ; pfam07238 426117002403 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117002404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117002405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117002406 DNA binding residues [nucleotide binding] 426117002407 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 426117002408 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 426117002409 DNA binding residues [nucleotide binding] 426117002410 dimer interface [polypeptide binding]; other site 426117002411 putative metal binding site [ion binding]; other site 426117002412 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 426117002413 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 426117002414 active site 426117002415 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117002416 MULE transposase domain; Region: MULE; pfam10551 426117002417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117002418 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117002419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117002420 TM-ABC transporter signature motif; other site 426117002421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117002422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117002423 TM-ABC transporter signature motif; other site 426117002424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117002425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117002426 Walker A/P-loop; other site 426117002427 ATP binding site [chemical binding]; other site 426117002428 Q-loop/lid; other site 426117002429 ABC transporter signature motif; other site 426117002430 Walker B; other site 426117002431 D-loop; other site 426117002432 H-loop/switch region; other site 426117002433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117002434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117002435 Walker A/P-loop; other site 426117002436 ATP binding site [chemical binding]; other site 426117002437 Q-loop/lid; other site 426117002438 ABC transporter signature motif; other site 426117002439 Walker B; other site 426117002440 D-loop; other site 426117002441 H-loop/switch region; other site 426117002442 Uncharacterized conserved protein [Function unknown]; Region: COG5476 426117002443 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 426117002444 MlrC C-terminus; Region: MlrC_C; pfam07171 426117002445 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426117002446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117002447 DNA-binding site [nucleotide binding]; DNA binding site 426117002448 FCD domain; Region: FCD; pfam07729 426117002449 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 426117002450 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117002451 inhibitor-cofactor binding pocket; inhibition site 426117002452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117002453 catalytic residue [active] 426117002454 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 426117002455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117002456 non-specific DNA binding site [nucleotide binding]; other site 426117002457 salt bridge; other site 426117002458 sequence-specific DNA binding site [nucleotide binding]; other site 426117002459 Cupin domain; Region: Cupin_2; pfam07883 426117002460 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 426117002461 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117002462 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117002463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 426117002464 NMT1/THI5 like; Region: NMT1; pfam09084 426117002465 membrane-bound complex binding site; other site 426117002466 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002468 dimer interface [polypeptide binding]; other site 426117002469 conserved gate region; other site 426117002470 putative PBP binding loops; other site 426117002471 ABC-ATPase subunit interface; other site 426117002472 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117002473 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117002474 Walker A/P-loop; other site 426117002475 ATP binding site [chemical binding]; other site 426117002476 Q-loop/lid; other site 426117002477 ABC transporter signature motif; other site 426117002478 Walker B; other site 426117002479 D-loop; other site 426117002480 H-loop/switch region; other site 426117002481 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426117002482 active site 426117002483 catalytic residues [active] 426117002484 DNA binding site [nucleotide binding] 426117002485 Int/Topo IB signature motif; other site 426117002486 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426117002487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117002488 DNA-binding site [nucleotide binding]; DNA binding site 426117002489 UTRA domain; Region: UTRA; pfam07702 426117002490 benzoate transport; Region: 2A0115; TIGR00895 426117002491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002492 putative substrate translocation pore; other site 426117002493 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426117002494 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117002495 active site 426117002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002497 D-galactonate transporter; Region: 2A0114; TIGR00893 426117002498 putative substrate translocation pore; other site 426117002499 tartrate dehydrogenase; Region: TTC; TIGR02089 426117002500 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 426117002501 acetolactate synthase; Reviewed; Region: PRK08322 426117002502 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117002503 PYR/PP interface [polypeptide binding]; other site 426117002504 dimer interface [polypeptide binding]; other site 426117002505 TPP binding site [chemical binding]; other site 426117002506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117002507 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 426117002508 TPP-binding site [chemical binding]; other site 426117002509 dimer interface [polypeptide binding]; other site 426117002510 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117002511 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 426117002512 putative active site [active] 426117002513 metal binding site [ion binding]; metal-binding site 426117002514 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 426117002515 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 426117002516 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426117002517 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 426117002518 Coenzyme A transferase; Region: CoA_trans; smart00882 426117002519 Coenzyme A transferase; Region: CoA_trans; cl17247 426117002520 adenylate kinase; Reviewed; Region: adk; PRK00279 426117002521 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 426117002522 AMP-binding site [chemical binding]; other site 426117002523 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 426117002524 Phasin protein; Region: Phasin_2; cl11491 426117002525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117002526 succinic semialdehyde dehydrogenase; Region: PLN02278 426117002527 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 426117002528 tetramerization interface [polypeptide binding]; other site 426117002529 NAD(P) binding site [chemical binding]; other site 426117002530 catalytic residues [active] 426117002531 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117002532 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 426117002533 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 426117002534 active site 426117002535 DNA binding site [nucleotide binding] 426117002536 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 426117002537 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117002538 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117002539 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426117002540 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426117002541 active site 426117002542 nucleophile elbow; other site 426117002543 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117002544 Citrate transporter; Region: CitMHS; pfam03600 426117002545 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 426117002546 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 426117002547 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 426117002548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117002549 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 426117002550 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 426117002551 active site 426117002552 metal binding site [ion binding]; metal-binding site 426117002553 interdomain interaction site; other site 426117002554 Domain of unknown function (DUF927); Region: DUF927; pfam06048 426117002555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117002556 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426117002557 active site 426117002558 Int/Topo IB signature motif; other site 426117002559 catalytic residues [active] 426117002560 DNA binding site [nucleotide binding] 426117002561 ParB-like nuclease domain; Region: ParB; smart00470 426117002562 multiple promoter invertase; Provisional; Region: mpi; PRK13413 426117002563 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117002564 catalytic residues [active] 426117002565 catalytic nucleophile [active] 426117002566 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117002567 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117002568 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117002569 Synaptic Site I dimer interface [polypeptide binding]; other site 426117002570 DNA binding site [nucleotide binding] 426117002571 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426117002572 DNA-binding interface [nucleotide binding]; DNA binding site 426117002573 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 426117002574 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117002575 active site 426117002576 DNA binding site [nucleotide binding] 426117002577 Int/Topo IB signature motif; other site 426117002578 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 426117002579 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 426117002580 substrate binding site [chemical binding]; other site 426117002581 ligand binding site [chemical binding]; other site 426117002582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117002583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002584 dimer interface [polypeptide binding]; other site 426117002585 conserved gate region; other site 426117002586 putative PBP binding loops; other site 426117002587 ABC-ATPase subunit interface; other site 426117002588 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 426117002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002590 dimer interface [polypeptide binding]; other site 426117002591 conserved gate region; other site 426117002592 putative PBP binding loops; other site 426117002593 ABC-ATPase subunit interface; other site 426117002594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426117002595 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426117002596 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 426117002597 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 426117002598 Walker A/P-loop; other site 426117002599 ATP binding site [chemical binding]; other site 426117002600 Q-loop/lid; other site 426117002601 ABC transporter signature motif; other site 426117002602 Walker B; other site 426117002603 D-loop; other site 426117002604 H-loop/switch region; other site 426117002605 TOBE domain; Region: TOBE_2; pfam08402 426117002606 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426117002607 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 426117002608 putative ligand binding site [chemical binding]; other site 426117002609 NAD binding site [chemical binding]; other site 426117002610 catalytic site [active] 426117002611 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117002612 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 426117002613 putative active site [active] 426117002614 metal binding site [ion binding]; metal-binding site 426117002615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117002616 PAS fold; Region: PAS_3; pfam08447 426117002617 putative active site [active] 426117002618 heme pocket [chemical binding]; other site 426117002619 PAS domain S-box; Region: sensory_box; TIGR00229 426117002620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117002621 putative active site [active] 426117002622 heme pocket [chemical binding]; other site 426117002623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117002624 HWE histidine kinase; Region: HWE_HK; smart00911 426117002625 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 426117002626 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426117002627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426117002628 N-terminal plug; other site 426117002629 ligand-binding site [chemical binding]; other site 426117002630 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 426117002631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117002632 malonic semialdehyde reductase; Provisional; Region: PRK10538 426117002633 NAD(P) binding site [chemical binding]; other site 426117002634 active site 426117002635 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 426117002636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117002637 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117002638 ligand binding site [chemical binding]; other site 426117002639 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 426117002640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002641 active site 426117002642 phosphorylation site [posttranslational modification] 426117002643 intermolecular recognition site; other site 426117002644 dimerization interface [polypeptide binding]; other site 426117002645 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117002646 Zn2+ binding site [ion binding]; other site 426117002647 Mg2+ binding site [ion binding]; other site 426117002648 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 426117002649 PBP superfamily domain; Region: PBP_like; pfam12727 426117002650 short chain dehydrogenase; Provisional; Region: PRK06701 426117002651 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 426117002652 NAD binding site [chemical binding]; other site 426117002653 metal binding site [ion binding]; metal-binding site 426117002654 active site 426117002655 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 426117002656 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 426117002657 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 426117002658 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 426117002659 RuvA N terminal domain; Region: RuvA_N; pfam01330 426117002660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117002661 dimer interface [polypeptide binding]; other site 426117002662 phosphorylation site [posttranslational modification] 426117002663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117002664 ATP binding site [chemical binding]; other site 426117002665 Mg2+ binding site [ion binding]; other site 426117002666 G-X-G motif; other site 426117002667 osmolarity response regulator; Provisional; Region: ompR; PRK09468 426117002668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002669 active site 426117002670 phosphorylation site [posttranslational modification] 426117002671 intermolecular recognition site; other site 426117002672 dimerization interface [polypeptide binding]; other site 426117002673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117002674 DNA binding site [nucleotide binding] 426117002675 Membrane fusogenic activity; Region: BMFP; pfam04380 426117002676 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 426117002677 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426117002678 TolR protein; Region: tolR; TIGR02801 426117002679 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 426117002680 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 426117002681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 426117002682 nucleotide binding site [chemical binding]; other site 426117002683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002684 active site 426117002685 phosphorylation site [posttranslational modification] 426117002686 intermolecular recognition site; other site 426117002687 dimerization interface [polypeptide binding]; other site 426117002688 FOG: WD40 repeat [General function prediction only]; Region: COG2319 426117002689 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 426117002690 structural tetrad; other site 426117002691 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 426117002692 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 426117002693 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 426117002694 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 426117002695 feedback inhibition sensing region; other site 426117002696 homohexameric interface [polypeptide binding]; other site 426117002697 nucleotide binding site [chemical binding]; other site 426117002698 N-acetyl-L-glutamate binding site [chemical binding]; other site 426117002699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117002700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117002701 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117002702 putative effector binding pocket; other site 426117002703 dimerization interface [polypeptide binding]; other site 426117002704 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117002705 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 426117002706 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 426117002707 metal binding site [ion binding]; metal-binding site 426117002708 dimer interface [polypeptide binding]; other site 426117002709 Uncharacterized conserved protein [Function unknown]; Region: COG5476 426117002710 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 426117002711 MlrC C-terminus; Region: MlrC_C; pfam07171 426117002712 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117002713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117002714 acyl-activating enzyme (AAE) consensus motif; other site 426117002715 AMP binding site [chemical binding]; other site 426117002716 active site 426117002717 CoA binding site [chemical binding]; other site 426117002718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 426117002719 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117002720 GAF domain; Region: GAF; pfam01590 426117002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117002722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117002723 dimer interface [polypeptide binding]; other site 426117002724 phosphorylation site [posttranslational modification] 426117002725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117002726 ATP binding site [chemical binding]; other site 426117002727 Mg2+ binding site [ion binding]; other site 426117002728 G-X-G motif; other site 426117002729 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117002730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117002731 active site 426117002732 phosphorylation site [posttranslational modification] 426117002733 intermolecular recognition site; other site 426117002734 dimerization interface [polypeptide binding]; other site 426117002735 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117002736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002737 putative substrate translocation pore; other site 426117002738 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117002739 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 426117002740 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 426117002741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117002742 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 426117002743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117002745 putative substrate translocation pore; other site 426117002746 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 426117002747 heme binding pocket [chemical binding]; other site 426117002748 heme ligand [chemical binding]; other site 426117002749 patatin-related protein; Region: TIGR03607 426117002750 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117002751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117002752 Walker A/P-loop; other site 426117002753 ATP binding site [chemical binding]; other site 426117002754 Q-loop/lid; other site 426117002755 ABC transporter signature motif; other site 426117002756 Walker B; other site 426117002757 D-loop; other site 426117002758 H-loop/switch region; other site 426117002759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426117002760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117002761 Walker A/P-loop; other site 426117002762 ATP binding site [chemical binding]; other site 426117002763 Q-loop/lid; other site 426117002764 ABC transporter signature motif; other site 426117002765 Walker B; other site 426117002766 D-loop; other site 426117002767 H-loop/switch region; other site 426117002768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426117002769 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 426117002770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002771 dimer interface [polypeptide binding]; other site 426117002772 conserved gate region; other site 426117002773 putative PBP binding loops; other site 426117002774 ABC-ATPase subunit interface; other site 426117002775 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117002776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117002777 dimer interface [polypeptide binding]; other site 426117002778 conserved gate region; other site 426117002779 putative PBP binding loops; other site 426117002780 ABC-ATPase subunit interface; other site 426117002781 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117002782 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 426117002783 peptide binding site [polypeptide binding]; other site 426117002784 dimer interface [polypeptide binding]; other site 426117002785 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 426117002786 amidohydrolase; Region: amidohydrolases; TIGR01891 426117002787 putative metal binding site [ion binding]; other site 426117002788 Flagellar protein FlaF; Region: FlaF; cl11454 426117002789 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 426117002790 putative active site [active] 426117002791 putative metal binding site [ion binding]; other site 426117002792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117002793 NAD(P) binding site [chemical binding]; other site 426117002794 active site 426117002795 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 426117002796 putative catalytic site [active] 426117002797 putative metal binding site [ion binding]; other site 426117002798 putative phosphate binding site [ion binding]; other site 426117002799 Predicted integral membrane protein [Function unknown]; Region: COG0392 426117002800 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 426117002801 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 426117002802 putative active site [active] 426117002803 catalytic site [active] 426117002804 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 426117002805 putative active site [active] 426117002806 catalytic site [active] 426117002807 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 426117002808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117002809 ATP binding site [chemical binding]; other site 426117002810 putative Mg++ binding site [ion binding]; other site 426117002811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117002812 nucleotide binding region [chemical binding]; other site 426117002813 ATP-binding site [chemical binding]; other site 426117002814 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117002815 39S ribosomal protein L53/MRP-L53; Region: MRP_L53; pfam10780 426117002816 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 426117002817 lipoyl-biotinyl attachment site [posttranslational modification]; other site 426117002818 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117002819 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117002820 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117002821 ligand binding site [chemical binding]; other site 426117002822 Caspase domain; Region: Peptidase_C14; pfam00656 426117002823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117002824 binding surface 426117002825 TPR repeat; Region: TPR_11; pfam13414 426117002826 TPR motif; other site 426117002827 TPR repeat; Region: TPR_11; pfam13414 426117002828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426117002829 TPR motif; other site 426117002830 binding surface 426117002831 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117002832 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117002833 ligand binding site [chemical binding]; other site 426117002834 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 426117002835 active site 426117002836 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 426117002837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 426117002838 active site 426117002839 ATP binding site [chemical binding]; other site 426117002840 substrate binding site [chemical binding]; other site 426117002841 activation loop (A-loop); other site 426117002842 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426117002843 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117002844 ligand binding site [chemical binding]; other site 426117002845 Nidogen-like; Region: NIDO; cl02648 426117002846 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 426117002847 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 426117002848 Autotransporter beta-domain; Region: Autotransporter; smart00869 426117002849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117002850 Zn2+ binding site [ion binding]; other site 426117002851 Mg2+ binding site [ion binding]; other site 426117002852 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117002853 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117002854 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426117002855 Caspase domain; Region: Peptidase_C14; pfam00656 426117002856 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117002857 cyclase homology domain; Region: CHD; cd07302 426117002858 nucleotidyl binding site; other site 426117002859 metal binding site [ion binding]; metal-binding site 426117002860 dimer interface [polypeptide binding]; other site 426117002861 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 426117002862 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 426117002863 phosphopeptide binding site; other site 426117002864 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 426117002865 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 426117002866 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117002867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117002869 putative substrate translocation pore; other site 426117002870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117002871 classical (c) SDRs; Region: SDR_c; cd05233 426117002872 NAD(P) binding site [chemical binding]; other site 426117002873 active site 426117002874 Porin subfamily; Region: Porin_2; pfam02530 426117002875 SWI complex, BAF60b domains; Region: SWIB; smart00151 426117002876 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117002877 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117002878 active site 426117002879 catalytic tetrad [active] 426117002880 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426117002881 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 426117002882 PRC-barrel domain; Region: PRC; pfam05239 426117002883 cytosine deaminase; Validated; Region: PRK07572 426117002884 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 426117002885 active site 426117002886 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 426117002887 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 426117002888 TM-ABC transporter signature motif; other site 426117002889 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 426117002890 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 426117002891 hypothetical protein; Validated; Region: PRK08238 426117002892 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 426117002893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426117002894 dimerization interface [polypeptide binding]; other site 426117002895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117002897 ATP binding site [chemical binding]; other site 426117002898 Mg2+ binding site [ion binding]; other site 426117002899 G-X-G motif; other site 426117002900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117002901 Ligand Binding Site [chemical binding]; other site 426117002902 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426117002903 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426117002904 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426117002905 Cytochrome c; Region: Cytochrom_C; pfam00034 426117002906 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117002907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117002908 active site 426117002909 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117002910 Methyltransferase domain; Region: Methyltransf_12; pfam08242 426117002911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117002912 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 426117002913 ligand binding site [chemical binding]; other site 426117002914 flexible hinge region; other site 426117002915 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117002916 putative switch regulator; other site 426117002917 non-specific DNA interactions [nucleotide binding]; other site 426117002918 DNA binding site [nucleotide binding] 426117002919 sequence specific DNA binding site [nucleotide binding]; other site 426117002920 putative cAMP binding site [chemical binding]; other site 426117002921 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 426117002922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117002923 FeS/SAM binding site; other site 426117002924 HemN C-terminal domain; Region: HemN_C; pfam06969 426117002925 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 426117002926 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426117002927 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426117002928 putative acyl-acceptor binding pocket; other site 426117002929 phosphoglycolate phosphatase; Provisional; Region: PRK13222 426117002930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117002931 motif II; other site 426117002932 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 426117002933 HTH-like domain; Region: HTH_21; pfam13276 426117002934 Integrase core domain; Region: rve; pfam00665 426117002935 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426117002936 DNA-binding interface [nucleotide binding]; DNA binding site 426117002937 Winged helix-turn helix; Region: HTH_29; pfam13551 426117002938 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117002939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117002940 Walker A motif; other site 426117002941 ATP binding site [chemical binding]; other site 426117002942 Walker B motif; other site 426117002943 arginine finger; other site 426117002944 GMP synthase; Reviewed; Region: guaA; PRK00074 426117002945 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 426117002946 AMP/PPi binding site [chemical binding]; other site 426117002947 candidate oxyanion hole; other site 426117002948 catalytic triad [active] 426117002949 potential glutamine specificity residues [chemical binding]; other site 426117002950 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 426117002951 ATP Binding subdomain [chemical binding]; other site 426117002952 Ligand Binding sites [chemical binding]; other site 426117002953 Dimerization subdomain; other site 426117002954 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426117002955 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117002956 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 426117002957 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 426117002958 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 426117002959 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426117002960 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 426117002961 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 426117002962 active site 426117002963 HD domain; Region: HD_4; pfam13328 426117002964 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 426117002965 active site 426117002966 Family description; Region: VCBS; pfam13517 426117002967 Family description; Region: VCBS; pfam13517 426117002968 Family description; Region: VCBS; pfam13517 426117002969 Family description; Region: VCBS; pfam13517 426117002970 Uncharacterized conserved protein [Function unknown]; Region: COG3791 426117002971 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426117002972 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 426117002973 putative active site [active] 426117002974 Zn binding site [ion binding]; other site 426117002975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117002976 D-galactonate transporter; Region: 2A0114; TIGR00893 426117002977 putative substrate translocation pore; other site 426117002978 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 426117002979 putative heme binding pocket [chemical binding]; other site 426117002980 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117002981 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 426117002982 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117002983 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117002984 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 426117002985 putative N-terminal domain interface [polypeptide binding]; other site 426117002986 Tetratricopeptide repeats; Region: TPR; smart00028 426117002987 Tetratricopeptide repeat; Region: TPR_16; pfam13432 426117002988 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117002989 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426117002990 IHF dimer interface [polypeptide binding]; other site 426117002991 IHF - DNA interface [nucleotide binding]; other site 426117002992 HTH-like domain; Region: HTH_21; pfam13276 426117002993 Integrase core domain; Region: rve; pfam00665 426117002994 Transposase; Region: HTH_Tnp_1; cl17663 426117002995 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 426117002996 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 426117002997 catalytic triad [active] 426117002998 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426117002999 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 426117003000 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 426117003001 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 426117003002 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 426117003003 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 426117003004 [4Fe-4S] binding site [ion binding]; other site 426117003005 molybdopterin cofactor binding site; other site 426117003006 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 426117003007 molybdopterin cofactor binding site; other site 426117003008 NapD protein; Region: NapD; pfam03927 426117003009 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 426117003010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117003011 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 426117003012 Chromate transporter; Region: Chromate_transp; pfam02417 426117003013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117003014 dimer interface [polypeptide binding]; other site 426117003015 putative CheW interface [polypeptide binding]; other site 426117003016 Hpt domain; Region: Hpt; pfam01627 426117003017 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117003018 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117003019 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426117003020 putative hydrophobic ligand binding site [chemical binding]; other site 426117003021 protein interface [polypeptide binding]; other site 426117003022 gate; other site 426117003023 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117003024 benzoate transport; Region: 2A0115; TIGR00895 426117003025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117003026 putative substrate translocation pore; other site 426117003027 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426117003028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117003029 active site 426117003030 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 426117003031 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 426117003032 active site 426117003033 catalytic site [active] 426117003034 substrate binding site [chemical binding]; other site 426117003035 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 426117003036 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 426117003037 CoA-binding site [chemical binding]; other site 426117003038 ATP-binding [chemical binding]; other site 426117003039 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 426117003040 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 426117003041 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 426117003042 shikimate binding site; other site 426117003043 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 426117003044 putative active site [active] 426117003045 PEP synthetase regulatory protein; Provisional; Region: PRK05339 426117003046 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 426117003047 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 426117003048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117003049 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 426117003050 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 426117003051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117003052 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 426117003053 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 426117003054 DNA binding site [nucleotide binding] 426117003055 active site 426117003056 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 426117003057 Transglycosylase; Region: Transgly; pfam00912 426117003058 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426117003059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426117003060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117003061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117003062 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 426117003063 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 426117003064 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117003065 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 426117003066 zinc binding site [ion binding]; other site 426117003067 putative ligand binding site [chemical binding]; other site 426117003068 PAS domain; Region: PAS_9; pfam13426 426117003069 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117003070 GAF domain; Region: GAF; pfam01590 426117003071 PAS fold; Region: PAS_3; pfam08447 426117003072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117003073 putative active site [active] 426117003074 heme pocket [chemical binding]; other site 426117003075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117003076 PAS fold; Region: PAS_3; pfam08447 426117003077 putative active site [active] 426117003078 heme pocket [chemical binding]; other site 426117003079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117003080 PAS fold; Region: PAS_3; pfam08447 426117003081 putative active site [active] 426117003082 heme pocket [chemical binding]; other site 426117003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117003084 dimer interface [polypeptide binding]; other site 426117003085 phosphorylation site [posttranslational modification] 426117003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117003087 ATP binding site [chemical binding]; other site 426117003088 Mg2+ binding site [ion binding]; other site 426117003089 G-X-G motif; other site 426117003090 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117003091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117003092 active site 426117003093 phosphorylation site [posttranslational modification] 426117003094 intermolecular recognition site; other site 426117003095 dimerization interface [polypeptide binding]; other site 426117003096 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117003097 IS2 transposase TnpB; Reviewed; Region: PRK09409 426117003098 HTH-like domain; Region: HTH_21; pfam13276 426117003099 Integrase core domain; Region: rve; pfam00665 426117003100 Integrase core domain; Region: rve_3; cl15866 426117003101 short chain dehydrogenase; Provisional; Region: PRK07109 426117003102 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426117003103 putative NAD(P) binding site [chemical binding]; other site 426117003104 active site 426117003105 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 426117003106 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117003107 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426117003108 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 426117003109 Predicted ATPase [General function prediction only]; Region: COG3911 426117003110 AAA domain; Region: AAA_28; pfam13521 426117003111 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 426117003112 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426117003113 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426117003114 PAS fold; Region: PAS_4; pfam08448 426117003115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117003116 HWE histidine kinase; Region: HWE_HK; pfam07536 426117003117 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117003118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003119 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117003120 SLBB domain; Region: SLBB; pfam10531 426117003121 Chain length determinant protein; Region: Wzz; cl15801 426117003122 AAA domain; Region: AAA_31; pfam13614 426117003123 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 426117003124 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117003125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117003126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117003128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117003129 active site 426117003130 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 426117003131 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426117003132 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117003133 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117003134 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117003135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117003137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117003138 active site 426117003139 PhoH-like protein; Region: PhoH; pfam02562 426117003140 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 426117003141 Part of AAA domain; Region: AAA_19; pfam13245 426117003142 Family description; Region: UvrD_C_2; pfam13538 426117003143 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426117003144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117003145 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117003146 protein binding site [polypeptide binding]; other site 426117003147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117003148 protein binding site [polypeptide binding]; other site 426117003149 HflC protein; Region: hflC; TIGR01932 426117003150 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 426117003151 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 426117003152 HflK protein; Region: hflK; TIGR01933 426117003153 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 426117003154 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 426117003155 folate binding site [chemical binding]; other site 426117003156 NADP+ binding site [chemical binding]; other site 426117003157 thymidylate synthase; Reviewed; Region: thyA; PRK01827 426117003158 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 426117003159 dimerization interface [polypeptide binding]; other site 426117003160 active site 426117003161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 426117003162 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117003163 Cytochrome P450; Region: p450; cl12078 426117003164 fumarate hydratase; Reviewed; Region: fumC; PRK00485 426117003165 Class II fumarases; Region: Fumarase_classII; cd01362 426117003166 active site 426117003167 tetramer interface [polypeptide binding]; other site 426117003168 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 426117003169 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 426117003170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117003171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117003172 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117003173 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117003174 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117003175 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117003176 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117003177 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 426117003178 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 426117003179 heme binding site [chemical binding]; other site 426117003180 ferroxidase pore; other site 426117003181 ferroxidase diiron center [ion binding]; other site 426117003182 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 426117003183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117003184 Walker A motif; other site 426117003185 ATP binding site [chemical binding]; other site 426117003186 Walker B motif; other site 426117003187 arginine finger; other site 426117003188 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 426117003189 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 426117003190 active site 426117003191 metal binding site [ion binding]; metal-binding site 426117003192 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426117003193 active site 426117003194 hypothetical protein; Provisional; Region: PRK06034 426117003195 Chorismate mutase type II; Region: CM_2; pfam01817 426117003196 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 426117003197 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 426117003198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117003199 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 426117003200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117003201 putative transporter; Provisional; Region: PRK10504 426117003202 putative substrate translocation pore; other site 426117003203 glutathione synthetase; Provisional; Region: PRK05246 426117003204 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 426117003205 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 426117003206 hypothetical protein; Provisional; Region: PRK05170 426117003207 Transglycosylase; Region: Transgly; pfam00912 426117003208 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426117003209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426117003210 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 426117003211 Predicted integral membrane protein [Function unknown]; Region: COG5436 426117003212 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 426117003213 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117003214 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426117003215 active site 426117003216 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426117003217 Autotransporter beta-domain; Region: Autotransporter; pfam03797 426117003218 Ion channel; Region: Ion_trans_2; pfam07885 426117003219 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117003220 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 426117003221 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 426117003222 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 426117003223 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 426117003224 catalytic site [active] 426117003225 active site 426117003226 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 426117003227 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 426117003228 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 426117003229 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 426117003230 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426117003231 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 426117003232 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117003233 cyclase homology domain; Region: CHD; cd07302 426117003234 nucleotidyl binding site; other site 426117003235 metal binding site [ion binding]; metal-binding site 426117003236 dimer interface [polypeptide binding]; other site 426117003237 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117003238 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 426117003239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117003240 TPR motif; other site 426117003241 binding surface 426117003242 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426117003243 active site 426117003244 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 426117003245 active site 426117003246 catalytic residues [active] 426117003247 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 426117003248 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 426117003249 tetrameric interface [polypeptide binding]; other site 426117003250 NAD binding site [chemical binding]; other site 426117003251 catalytic residues [active] 426117003252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117003253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003254 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426117003255 dimerization interface [polypeptide binding]; other site 426117003256 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 426117003257 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 426117003258 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426117003259 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426117003260 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 426117003261 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 426117003262 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 426117003263 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117003264 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 426117003265 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 426117003266 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117003267 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117003268 hypothetical protein; Provisional; Region: PRK14709 426117003269 D5 N terminal like; Region: D5_N; smart00885 426117003270 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 426117003271 polymerase nucleotide-binding site; other site 426117003272 DNA-binding residues [nucleotide binding]; DNA binding site 426117003273 nucleotide binding site [chemical binding]; other site 426117003274 primase nucleotide-binding site [nucleotide binding]; other site 426117003275 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 426117003276 Helix-turn-helix domain; Region: HTH_17; cl17695 426117003277 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 426117003278 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117003279 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 426117003280 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 426117003281 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 426117003282 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 426117003283 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117003284 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 426117003285 tetramerization interface [polypeptide binding]; other site 426117003286 NAD(P) binding site [chemical binding]; other site 426117003287 catalytic residues [active] 426117003288 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426117003289 active site 426117003290 catalytic residues [active] 426117003291 DNA binding site [nucleotide binding] 426117003292 Int/Topo IB signature motif; other site 426117003293 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426117003294 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426117003295 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 426117003296 amphipathic channel; other site 426117003297 Asn-Pro-Ala signature motifs; other site 426117003298 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 426117003299 Sulfatase; Region: Sulfatase; pfam00884 426117003300 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 426117003301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117003302 motif II; other site 426117003303 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 426117003304 Uncharacterized conserved protein [Function unknown]; Region: COG1262 426117003305 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117003306 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 426117003307 MoxR-like ATPases [General function prediction only]; Region: COG0714 426117003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117003309 Walker A motif; other site 426117003310 ATP binding site [chemical binding]; other site 426117003311 Walker B motif; other site 426117003312 arginine finger; other site 426117003313 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 426117003314 Protein of unknown function DUF58; Region: DUF58; pfam01882 426117003315 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 426117003316 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426117003317 metal ion-dependent adhesion site (MIDAS); other site 426117003318 von Willebrand factor type A domain; Region: VWA_2; pfam13519 426117003319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117003320 TPR motif; other site 426117003321 binding surface 426117003322 TPR repeat; Region: TPR_11; pfam13414 426117003323 Oxygen tolerance; Region: BatD; pfam13584 426117003324 Uncharacterized conserved protein [Function unknown]; Region: COG5361 426117003325 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 426117003326 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 426117003327 Uncharacterized conserved protein [Function unknown]; Region: COG5361 426117003328 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 426117003329 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 426117003330 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 426117003331 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117003332 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117003333 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 426117003334 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426117003335 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117003336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117003337 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117003338 Phage Terminase; Region: Terminase_1; pfam03354 426117003339 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426117003340 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117003341 catalytic residues [active] 426117003342 catalytic nucleophile [active] 426117003343 Recombinase; Region: Recombinase; pfam07508 426117003344 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 426117003345 active site 426117003346 metal binding site [ion binding]; metal-binding site 426117003347 interdomain interaction site; other site 426117003348 AAA domain; Region: AAA_25; pfam13481 426117003349 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 426117003350 Walker A motif; other site 426117003351 NTP binding site [chemical binding]; other site 426117003352 hexamer interface [polypeptide binding]; other site 426117003353 Walker B motif; other site 426117003354 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 426117003355 GAF domain; Region: GAF; pfam01590 426117003356 PAS domain S-box; Region: sensory_box; TIGR00229 426117003357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117003358 putative active site [active] 426117003359 heme pocket [chemical binding]; other site 426117003360 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426117003361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117003362 active site 426117003363 phosphorylation site [posttranslational modification] 426117003364 intermolecular recognition site; other site 426117003365 dimerization interface [polypeptide binding]; other site 426117003366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117003367 DNA binding residues [nucleotide binding] 426117003368 dimerization interface [polypeptide binding]; other site 426117003369 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117003370 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117003371 ligand binding site [chemical binding]; other site 426117003372 flexible hinge region; other site 426117003373 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117003374 putative switch regulator; other site 426117003375 non-specific DNA interactions [nucleotide binding]; other site 426117003376 DNA binding site [nucleotide binding] 426117003377 sequence specific DNA binding site [nucleotide binding]; other site 426117003378 putative cAMP binding site [chemical binding]; other site 426117003379 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 426117003380 active site 426117003381 catalytic residues [active] 426117003382 metal binding site [ion binding]; metal-binding site 426117003383 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117003384 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 426117003385 active site 426117003386 NAD binding site [chemical binding]; other site 426117003387 metal binding site [ion binding]; metal-binding site 426117003388 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117003389 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117003390 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 426117003391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117003392 DNA-binding site [nucleotide binding]; DNA binding site 426117003393 FCD domain; Region: FCD; pfam07729 426117003394 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117003395 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117003396 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426117003397 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 426117003398 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 426117003399 dimer interface [polypeptide binding]; other site 426117003400 TPP-binding site [chemical binding]; other site 426117003401 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426117003402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117003403 E3 interaction surface; other site 426117003404 lipoyl attachment site [posttranslational modification]; other site 426117003405 e3 binding domain; Region: E3_binding; pfam02817 426117003406 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426117003407 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117003408 E3 interaction surface; other site 426117003409 lipoyl attachment site [posttranslational modification]; other site 426117003410 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 426117003411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117003412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117003413 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426117003414 malate dehydrogenase; Provisional; Region: PRK13529 426117003415 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426117003416 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 426117003417 NAD(P) binding pocket [chemical binding]; other site 426117003418 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 426117003419 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426117003420 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426117003421 putative NAD(P) binding site [chemical binding]; other site 426117003422 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 426117003423 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426117003424 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117003425 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426117003426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117003427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117003428 putative acyltransferase; Provisional; Region: PRK05790 426117003429 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426117003430 dimer interface [polypeptide binding]; other site 426117003431 active site 426117003432 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 426117003433 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 426117003434 NAD(P) binding site [chemical binding]; other site 426117003435 homotetramer interface [polypeptide binding]; other site 426117003436 homodimer interface [polypeptide binding]; other site 426117003437 active site 426117003438 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 426117003439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117003440 dimer interface [polypeptide binding]; other site 426117003441 phosphorylation site [posttranslational modification] 426117003442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117003443 ATP binding site [chemical binding]; other site 426117003444 Mg2+ binding site [ion binding]; other site 426117003445 G-X-G motif; other site 426117003446 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426117003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117003448 active site 426117003449 phosphorylation site [posttranslational modification] 426117003450 intermolecular recognition site; other site 426117003451 dimerization interface [polypeptide binding]; other site 426117003452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117003453 Walker A motif; other site 426117003454 ATP binding site [chemical binding]; other site 426117003455 Walker B motif; other site 426117003456 arginine finger; other site 426117003457 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117003458 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426117003459 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 426117003460 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426117003461 lipoyl synthase; Provisional; Region: PRK05481 426117003462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117003463 FeS/SAM binding site; other site 426117003464 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 426117003465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117003466 substrate binding pocket [chemical binding]; other site 426117003467 membrane-bound complex binding site; other site 426117003468 Phasin protein; Region: Phasin_2; cl11491 426117003469 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 426117003470 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426117003471 putative NAD(P) binding site [chemical binding]; other site 426117003472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117003473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003474 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426117003475 dimerization interface [polypeptide binding]; other site 426117003476 Domain of unknown function DUF302; Region: DUF302; cl01364 426117003477 Dodecin; Region: Dodecin; pfam07311 426117003478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117003479 dimerization interface [polypeptide binding]; other site 426117003480 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117003481 dimer interface [polypeptide binding]; other site 426117003482 putative CheW interface [polypeptide binding]; other site 426117003483 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426117003484 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 426117003485 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 426117003486 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117003487 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426117003488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117003489 ATP binding site [chemical binding]; other site 426117003490 putative Mg++ binding site [ion binding]; other site 426117003491 nucleotide binding region [chemical binding]; other site 426117003492 helicase superfamily c-terminal domain; Region: HELICc; smart00490 426117003493 ATP-binding site [chemical binding]; other site 426117003494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117003495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117003496 non-specific DNA binding site [nucleotide binding]; other site 426117003497 salt bridge; other site 426117003498 sequence-specific DNA binding site [nucleotide binding]; other site 426117003499 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426117003500 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426117003501 Walker A/P-loop; other site 426117003502 ATP binding site [chemical binding]; other site 426117003503 Q-loop/lid; other site 426117003504 ABC transporter signature motif; other site 426117003505 Walker B; other site 426117003506 D-loop; other site 426117003507 H-loop/switch region; other site 426117003508 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117003509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117003510 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117003511 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117003512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117003513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117003514 DNA binding residues [nucleotide binding] 426117003515 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426117003516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003517 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117003518 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426117003519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003520 Hint domain; Region: Hint_2; pfam13403 426117003521 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 426117003522 FecR protein; Region: FecR; pfam04773 426117003523 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426117003524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117003525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117003526 dimer interface [polypeptide binding]; other site 426117003527 phosphorylation site [posttranslational modification] 426117003528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117003529 ATP binding site [chemical binding]; other site 426117003530 Mg2+ binding site [ion binding]; other site 426117003531 G-X-G motif; other site 426117003532 Response regulator receiver domain; Region: Response_reg; pfam00072 426117003533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117003534 active site 426117003535 phosphorylation site [posttranslational modification] 426117003536 intermolecular recognition site; other site 426117003537 dimerization interface [polypeptide binding]; other site 426117003538 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 426117003539 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 426117003540 aspartate aminotransferase; Provisional; Region: PRK06108 426117003541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117003542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117003543 homodimer interface [polypeptide binding]; other site 426117003544 catalytic residue [active] 426117003545 Uncharacterized conserved protein [Function unknown]; Region: COG1359 426117003546 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 426117003547 Na binding site [ion binding]; other site 426117003548 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 426117003549 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426117003550 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117003551 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117003552 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117003553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117003554 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 426117003555 hydrophobic ligand binding site; other site 426117003556 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426117003557 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426117003558 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117003559 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117003560 catalytic loop [active] 426117003561 iron binding site [ion binding]; other site 426117003562 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117003563 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117003564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117003565 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 426117003566 acyl-activating enzyme (AAE) consensus motif; other site 426117003567 putative AMP binding site [chemical binding]; other site 426117003568 putative active site [active] 426117003569 putative CoA binding site [chemical binding]; other site 426117003570 enoyl-CoA hydratase; Provisional; Region: PRK06688 426117003571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117003572 substrate binding site [chemical binding]; other site 426117003573 oxyanion hole (OAH) forming residues; other site 426117003574 trimer interface [polypeptide binding]; other site 426117003575 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117003577 putative substrate translocation pore; other site 426117003578 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 426117003579 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 426117003580 Flavoprotein; Region: Flavoprotein; pfam02441 426117003581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117003582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117003584 dimerization interface [polypeptide binding]; other site 426117003585 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 426117003586 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426117003587 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426117003588 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426117003589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117003590 DNA-binding site [nucleotide binding]; DNA binding site 426117003591 FCD domain; Region: FCD; pfam07729 426117003592 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426117003593 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426117003594 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 426117003595 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 426117003596 Walker A/P-loop; other site 426117003597 ATP binding site [chemical binding]; other site 426117003598 Q-loop/lid; other site 426117003599 ABC transporter signature motif; other site 426117003600 Walker B; other site 426117003601 D-loop; other site 426117003602 H-loop/switch region; other site 426117003603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117003604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117003605 dimer interface [polypeptide binding]; other site 426117003606 conserved gate region; other site 426117003607 putative PBP binding loops; other site 426117003608 ABC-ATPase subunit interface; other site 426117003609 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426117003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117003611 dimer interface [polypeptide binding]; other site 426117003612 conserved gate region; other site 426117003613 putative PBP binding loops; other site 426117003614 ABC-ATPase subunit interface; other site 426117003615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117003616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426117003617 dihydroxy-acid dehydratase; Validated; Region: PRK06131 426117003618 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 426117003619 oligomer interface [polypeptide binding]; other site 426117003620 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117003621 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 426117003622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003623 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 426117003624 dimerizarion interface [polypeptide binding]; other site 426117003625 CrgA pocket; other site 426117003626 substrate binding pocket [chemical binding]; other site 426117003627 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 426117003628 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 426117003629 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 426117003630 putative alpha subunit interface [polypeptide binding]; other site 426117003631 putative active site [active] 426117003632 putative substrate binding site [chemical binding]; other site 426117003633 Fe binding site [ion binding]; other site 426117003634 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 426117003635 inter-subunit interface; other site 426117003636 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 426117003637 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117003638 catalytic loop [active] 426117003639 iron binding site [ion binding]; other site 426117003640 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 426117003641 FAD binding pocket [chemical binding]; other site 426117003642 FAD binding motif [chemical binding]; other site 426117003643 phosphate binding motif [ion binding]; other site 426117003644 beta-alpha-beta structure motif; other site 426117003645 NAD binding pocket [chemical binding]; other site 426117003646 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 426117003647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117003648 NAD(P) binding site [chemical binding]; other site 426117003649 active site 426117003650 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 426117003651 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 426117003652 dimer interface [polypeptide binding]; other site 426117003653 active site 426117003654 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 426117003655 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 426117003656 metal binding site [ion binding]; metal-binding site 426117003657 substrate binding pocket [chemical binding]; other site 426117003658 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 426117003659 benzoate transport; Region: 2A0115; TIGR00895 426117003660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117003661 putative substrate translocation pore; other site 426117003662 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117003663 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426117003664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117003665 DNA-binding site [nucleotide binding]; DNA binding site 426117003666 FCD domain; Region: FCD; pfam07729 426117003667 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 426117003668 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117003669 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117003670 putative ligand binding site [chemical binding]; other site 426117003671 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 426117003672 Coenzyme A transferase; Region: CoA_trans; smart00882 426117003673 Coenzyme A transferase; Region: CoA_trans; cl17247 426117003674 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 426117003675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117003676 substrate binding site [chemical binding]; other site 426117003677 oxyanion hole (OAH) forming residues; other site 426117003678 trimer interface [polypeptide binding]; other site 426117003679 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117003680 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117003681 putative ligand binding site [chemical binding]; other site 426117003682 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426117003683 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 426117003684 putative active site [active] 426117003685 allantoate amidohydrolase; Region: AllC; TIGR03176 426117003686 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426117003687 active site 426117003688 metal binding site [ion binding]; metal-binding site 426117003689 dimer interface [polypeptide binding]; other site 426117003690 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 426117003691 catalytic residue [active] 426117003692 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117003693 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 426117003694 AsnC family; Region: AsnC_trans_reg; pfam01037 426117003695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117003696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 426117003698 putative effector binding pocket; other site 426117003699 putative dimerization interface [polypeptide binding]; other site 426117003700 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426117003701 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426117003702 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426117003703 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 426117003704 FAD binding pocket [chemical binding]; other site 426117003705 FAD binding motif [chemical binding]; other site 426117003706 phosphate binding motif [ion binding]; other site 426117003707 beta-alpha-beta structure motif; other site 426117003708 NAD binding pocket [chemical binding]; other site 426117003709 Heme binding pocket [chemical binding]; other site 426117003710 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117003711 catalytic loop [active] 426117003712 iron binding site [ion binding]; other site 426117003713 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117003714 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 426117003715 putative C-terminal domain interface [polypeptide binding]; other site 426117003716 putative GSH binding site (G-site) [chemical binding]; other site 426117003717 putative dimer interface [polypeptide binding]; other site 426117003718 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 426117003719 putative N-terminal domain interface [polypeptide binding]; other site 426117003720 putative dimer interface [polypeptide binding]; other site 426117003721 putative substrate binding pocket (H-site) [chemical binding]; other site 426117003722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117003723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117003724 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117003725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117003726 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 426117003727 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 426117003728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117003729 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 426117003730 DNA binding residues [nucleotide binding] 426117003731 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426117003732 nucleophile elbow; other site 426117003733 Patatin phospholipase; Region: DUF3734; pfam12536 426117003734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117003735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117003737 dimerization interface [polypeptide binding]; other site 426117003738 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 426117003739 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117003740 putative catalytic residues [active] 426117003741 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 426117003742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426117003743 active site 426117003744 Predicted flavoprotein [General function prediction only]; Region: COG0431 426117003745 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117003746 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426117003747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117003748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117003749 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426117003750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117003751 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426117003752 dimerization interface [polypeptide binding]; other site 426117003753 substrate binding pocket [chemical binding]; other site 426117003754 TLC ATP/ADP transporter; Region: TLC; cl03940 426117003755 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 426117003756 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 426117003757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117003758 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117003759 active site 426117003760 catalytic tetrad [active] 426117003761 preprotein translocase subunit SecB; Validated; Region: PRK05751 426117003762 SecA binding site; other site 426117003763 Preprotein binding site; other site 426117003764 Tim44-like domain; Region: Tim44; pfam04280 426117003765 MltA specific insert domain; Region: MltA; smart00925 426117003766 3D domain; Region: 3D; pfam06725 426117003767 Smr domain; Region: Smr; pfam01713 426117003768 transcription termination factor Rho; Provisional; Region: rho; PRK09376 426117003769 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 426117003770 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 426117003771 RNA binding site [nucleotide binding]; other site 426117003772 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 426117003773 multimer interface [polypeptide binding]; other site 426117003774 Walker A motif; other site 426117003775 ATP binding site [chemical binding]; other site 426117003776 Walker B motif; other site 426117003777 PAS domain; Region: PAS; smart00091 426117003778 PAS fold; Region: PAS_7; pfam12860 426117003779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117003780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117003781 metal binding site [ion binding]; metal-binding site 426117003782 active site 426117003783 I-site; other site 426117003784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117003785 NHL repeat; Region: NHL; pfam01436 426117003786 Uncharacterized conserved protein [Function unknown]; Region: COG3391 426117003787 NHL repeat; Region: NHL; pfam01436 426117003788 NHL repeat; Region: NHL; pfam01436 426117003789 PAS domain; Region: PAS_9; pfam13426 426117003790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117003791 putative active site [active] 426117003792 heme pocket [chemical binding]; other site 426117003793 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117003794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117003795 dimer interface [polypeptide binding]; other site 426117003796 putative CheW interface [polypeptide binding]; other site 426117003797 MoxR-like ATPases [General function prediction only]; Region: COG0714 426117003798 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 426117003799 ATP binding site [chemical binding]; other site 426117003800 Walker A motif; other site 426117003801 Walker B motif; other site 426117003802 arginine finger; other site 426117003803 Protein of unknown function DUF58; Region: DUF58; pfam01882 426117003804 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426117003805 metal ion-dependent adhesion site (MIDAS); other site 426117003806 von Willebrand factor type A domain; Region: VWA_2; pfam13519 426117003807 Oxygen tolerance; Region: BatD; pfam13584 426117003808 beta-lactamase TEM; Provisional; Region: PRK15442 426117003809 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 426117003810 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 426117003811 putative deacylase active site [active] 426117003812 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 426117003813 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 426117003814 Cu(I) binding site [ion binding]; other site 426117003815 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 426117003816 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 426117003817 putative sugar binding sites [chemical binding]; other site 426117003818 Q-X-W motif; other site 426117003819 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 426117003820 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 426117003821 putative sugar binding sites [chemical binding]; other site 426117003822 Q-X-W motif; other site 426117003823 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 426117003824 Kelch motif; Region: Kelch_6; pfam13964 426117003825 Kelch motif; Region: Kelch_6; pfam13964 426117003826 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 426117003827 pantoate--beta-alanine ligase; Region: panC; TIGR00018 426117003828 Pantoate-beta-alanine ligase; Region: PanC; cd00560 426117003829 active site 426117003830 ATP-binding site [chemical binding]; other site 426117003831 pantoate-binding site; other site 426117003832 HXXH motif; other site 426117003833 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 426117003834 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 426117003835 trimer interface [polypeptide binding]; other site 426117003836 active site 426117003837 substrate binding site [chemical binding]; other site 426117003838 CoA binding site [chemical binding]; other site 426117003839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117003840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117003841 ligand binding site [chemical binding]; other site 426117003842 flexible hinge region; other site 426117003843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117003844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117003845 active site 426117003846 phosphorylation site [posttranslational modification] 426117003847 intermolecular recognition site; other site 426117003848 dimerization interface [polypeptide binding]; other site 426117003849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117003850 DNA binding site [nucleotide binding] 426117003851 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 426117003852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426117003853 active site 426117003854 catalytic site [active] 426117003855 substrate binding site [chemical binding]; other site 426117003856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 426117003857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 426117003858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426117003859 catalytic residue [active] 426117003860 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 426117003861 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 426117003862 HIGH motif; other site 426117003863 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426117003864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117003865 active site 426117003866 KMSKS motif; other site 426117003867 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 426117003868 tRNA binding surface [nucleotide binding]; other site 426117003869 Lipopolysaccharide-assembly; Region: LptE; cl01125 426117003870 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 426117003871 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 426117003872 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 426117003873 ParB-like nuclease domain; Region: ParBc; pfam02195 426117003874 KorB domain; Region: KorB; pfam08535 426117003875 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426117003876 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117003877 P-loop; other site 426117003878 Magnesium ion binding site [ion binding]; other site 426117003879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117003880 Magnesium ion binding site [ion binding]; other site 426117003881 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 426117003882 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 426117003883 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 426117003884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117003885 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 426117003886 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 426117003887 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 426117003888 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 426117003889 trmE is a tRNA modification GTPase; Region: trmE; cd04164 426117003890 G1 box; other site 426117003891 GTP/Mg2+ binding site [chemical binding]; other site 426117003892 Switch I region; other site 426117003893 G2 box; other site 426117003894 Switch II region; other site 426117003895 G3 box; other site 426117003896 G4 box; other site 426117003897 G5 box; other site 426117003898 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 426117003899 glucosyltransferase MdoH; Provisional; Region: PRK05454 426117003900 active site 426117003901 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 426117003902 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 426117003903 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117003904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117003905 catalytic residue [active] 426117003906 TspO/MBR family; Region: TspO_MBR; pfam03073 426117003907 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 426117003908 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117003909 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117003910 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117003911 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117003912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117003913 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 426117003914 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117003915 catalytic loop [active] 426117003916 iron binding site [ion binding]; other site 426117003917 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117003918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117003919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117003920 active site 426117003921 catalytic tetrad [active] 426117003922 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117003923 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117003924 putative ligand binding site [chemical binding]; other site 426117003925 methionine sulfoxide reductase B; Provisional; Region: PRK00222 426117003926 SelR domain; Region: SelR; pfam01641 426117003927 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426117003928 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117003929 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117003930 tellurite resistance protein terB; Region: terB; cd07176 426117003931 putative metal binding site [ion binding]; other site 426117003932 pyridoxamine kinase; Validated; Region: PRK05756 426117003933 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 426117003934 dimer interface [polypeptide binding]; other site 426117003935 pyridoxal binding site [chemical binding]; other site 426117003936 ATP binding site [chemical binding]; other site 426117003937 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426117003938 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 426117003939 NMT1-like family; Region: NMT1_2; pfam13379 426117003940 NMT1/THI5 like; Region: NMT1; pfam09084 426117003941 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117003942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117003943 dimer interface [polypeptide binding]; other site 426117003944 conserved gate region; other site 426117003945 putative PBP binding loops; other site 426117003946 ABC-ATPase subunit interface; other site 426117003947 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117003948 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117003949 Walker A/P-loop; other site 426117003950 ATP binding site [chemical binding]; other site 426117003951 Q-loop/lid; other site 426117003952 ABC transporter signature motif; other site 426117003953 Walker B; other site 426117003954 D-loop; other site 426117003955 H-loop/switch region; other site 426117003956 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426117003957 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426117003958 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 426117003959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426117003960 N-terminal plug; other site 426117003961 ligand-binding site [chemical binding]; other site 426117003962 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 426117003963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117003964 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 426117003965 NAD(P) binding site [chemical binding]; other site 426117003966 active site 426117003967 Predicted ATPase [General function prediction only]; Region: COG3910 426117003968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117003969 Walker A/P-loop; other site 426117003970 ATP binding site [chemical binding]; other site 426117003971 ABC transporter signature motif; other site 426117003972 Walker B; other site 426117003973 D-loop; other site 426117003974 H-loop/switch region; other site 426117003975 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 426117003976 NUDIX domain; Region: NUDIX; pfam00293 426117003977 2-isopropylmalate synthase; Validated; Region: PRK00915 426117003978 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 426117003979 active site 426117003980 catalytic residues [active] 426117003981 metal binding site [ion binding]; metal-binding site 426117003982 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 426117003983 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117003984 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117003985 Integrase core domain; Region: rve; pfam00665 426117003986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117003987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117003988 ligand binding site [chemical binding]; other site 426117003989 flexible hinge region; other site 426117003990 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117003991 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 426117003992 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 426117003993 substrate binding site; other site 426117003994 tetramer interface; other site 426117003995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117003996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117003997 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117003998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117003999 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 426117004000 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117004001 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 426117004002 SLBB domain; Region: SLBB; pfam10531 426117004003 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117004004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117004005 Chain length determinant protein; Region: Wzz; pfam02706 426117004006 Chain length determinant protein; Region: Wzz; cl15801 426117004007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 426117004008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117004009 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 426117004010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117004011 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117004012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117004013 Walker A motif; other site 426117004014 ATP binding site [chemical binding]; other site 426117004015 Walker B motif; other site 426117004016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117004017 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117004018 Integrase core domain; Region: rve; pfam00665 426117004019 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 426117004020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117004021 Transposase; Region: HTH_Tnp_1; pfam01527 426117004022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 426117004023 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 426117004024 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117004025 Winged helix-turn helix; Region: HTH_29; pfam13551 426117004026 Winged helix-turn helix; Region: HTH_33; pfam13592 426117004027 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117004028 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 426117004029 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117004030 active site 426117004031 DNA binding site [nucleotide binding] 426117004032 Int/Topo IB signature motif; other site 426117004033 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117004034 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117004035 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426117004036 catalytic residues [active] 426117004037 catalytic nucleophile [active] 426117004038 Recombinase; Region: Recombinase; pfam07508 426117004039 ParB-like nuclease domain; Region: ParB; smart00470 426117004040 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 426117004041 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426117004042 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 426117004043 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117004044 active site 426117004045 DNA binding site [nucleotide binding] 426117004046 Int/Topo IB signature motif; other site 426117004047 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 426117004048 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 426117004049 cofactor binding site; other site 426117004050 DNA binding site [nucleotide binding] 426117004051 substrate interaction site [chemical binding]; other site 426117004052 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 426117004053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117004054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004055 phosphorylation site [posttranslational modification] 426117004056 intermolecular recognition site; other site 426117004057 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 426117004058 Mg2+ binding site [ion binding]; other site 426117004059 G-X-G motif; other site 426117004060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117004061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004062 ATP binding site [chemical binding]; other site 426117004063 Mg2+ binding site [ion binding]; other site 426117004064 G-X-G motif; other site 426117004065 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 426117004066 additional DNA contacts [nucleotide binding]; other site 426117004067 mismatch recognition site; other site 426117004068 active site 426117004069 zinc binding site [ion binding]; other site 426117004070 DNA intercalation site [nucleotide binding]; other site 426117004071 Domain of unknown function DUF87; Region: DUF87; pfam01935 426117004072 AAA-like domain; Region: AAA_10; pfam12846 426117004073 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 426117004074 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 426117004075 cofactor binding site; other site 426117004076 DNA binding site [nucleotide binding] 426117004077 substrate interaction site [chemical binding]; other site 426117004078 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 426117004079 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 426117004080 active site 426117004081 Fe-S cluster binding site [ion binding]; other site 426117004082 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117004083 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117004084 Integrase core domain; Region: rve; pfam00665 426117004085 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 426117004086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117004087 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 426117004088 Walker A motif; other site 426117004089 ATP binding site [chemical binding]; other site 426117004090 Walker B motif; other site 426117004091 arginine finger; other site 426117004092 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117004093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117004094 Walker A motif; other site 426117004095 ATP binding site [chemical binding]; other site 426117004096 Walker B motif; other site 426117004097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117004098 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117004099 Integrase core domain; Region: rve; pfam00665 426117004100 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426117004101 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426117004102 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 426117004103 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 426117004104 Homeodomain-like domain; Region: HTH_23; pfam13384 426117004105 Winged helix-turn helix; Region: HTH_29; pfam13551 426117004106 Integrase core domain; Region: rve; pfam00665 426117004107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117004108 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426117004109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117004110 MviN-like protein; Region: MVIN; pfam03023 426117004111 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426117004112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117004113 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117004114 transcriptional regulator; Provisional; Region: PRK10632 426117004115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117004116 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 426117004117 putative effector binding pocket; other site 426117004118 putative dimerization interface [polypeptide binding]; other site 426117004119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117004120 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117004121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117004122 DNA-binding site [nucleotide binding]; DNA binding site 426117004123 FCD domain; Region: FCD; pfam07729 426117004124 formyl-coenzyme A transferase; Provisional; Region: PRK05398 426117004125 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 426117004126 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 426117004127 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 426117004128 CoA binding domain; Region: CoA_binding_2; pfam13380 426117004129 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 426117004130 PAS fold; Region: PAS_7; pfam12860 426117004131 PAS fold; Region: PAS_3; pfam08447 426117004132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004133 putative active site [active] 426117004134 heme pocket [chemical binding]; other site 426117004135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117004136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004137 dimer interface [polypeptide binding]; other site 426117004138 phosphorylation site [posttranslational modification] 426117004139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004140 ATP binding site [chemical binding]; other site 426117004141 Mg2+ binding site [ion binding]; other site 426117004142 G-X-G motif; other site 426117004143 Response regulator receiver domain; Region: Response_reg; pfam00072 426117004144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004145 active site 426117004146 phosphorylation site [posttranslational modification] 426117004147 intermolecular recognition site; other site 426117004148 dimerization interface [polypeptide binding]; other site 426117004149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117004150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004151 active site 426117004152 phosphorylation site [posttranslational modification] 426117004153 intermolecular recognition site; other site 426117004154 dimerization interface [polypeptide binding]; other site 426117004155 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117004156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004157 active site 426117004158 phosphorylation site [posttranslational modification] 426117004159 intermolecular recognition site; other site 426117004160 dimerization interface [polypeptide binding]; other site 426117004161 Response regulator receiver domain; Region: Response_reg; pfam00072 426117004162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004163 active site 426117004164 phosphorylation site [posttranslational modification] 426117004165 intermolecular recognition site; other site 426117004166 dimerization interface [polypeptide binding]; other site 426117004167 cyclase homology domain; Region: CHD; cd07302 426117004168 nucleotidyl binding site; other site 426117004169 metal binding site [ion binding]; metal-binding site 426117004170 dimer interface [polypeptide binding]; other site 426117004171 Cupin domain; Region: Cupin_2; pfam07883 426117004172 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426117004173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004174 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 426117004175 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117004177 putative substrate translocation pore; other site 426117004178 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 426117004179 CsbD-like; Region: CsbD; pfam05532 426117004180 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 426117004181 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 426117004182 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117004183 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 426117004184 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 426117004185 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117004186 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 426117004187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117004188 NAD(P) binding site [chemical binding]; other site 426117004189 active site 426117004190 DevC protein; Region: devC; TIGR01185 426117004191 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426117004192 FtsX-like permease family; Region: FtsX; pfam02687 426117004193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117004194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117004195 Walker A/P-loop; other site 426117004196 ATP binding site [chemical binding]; other site 426117004197 Q-loop/lid; other site 426117004198 ABC transporter signature motif; other site 426117004199 Walker B; other site 426117004200 D-loop; other site 426117004201 H-loop/switch region; other site 426117004202 response regulator; Provisional; Region: PRK13435 426117004203 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 426117004204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117004205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117004206 homodimer interface [polypeptide binding]; other site 426117004207 catalytic residue [active] 426117004208 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117004209 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117004210 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117004211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117004212 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117004213 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117004214 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 426117004215 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 426117004216 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426117004217 NAD binding site [chemical binding]; other site 426117004218 homotetramer interface [polypeptide binding]; other site 426117004219 homodimer interface [polypeptide binding]; other site 426117004220 substrate binding site [chemical binding]; other site 426117004221 active site 426117004222 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 426117004223 propionate/acetate kinase; Provisional; Region: PRK12379 426117004224 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 426117004225 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 426117004226 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 426117004227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426117004228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117004229 Coenzyme A binding pocket [chemical binding]; other site 426117004230 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 426117004231 Coenzyme A transferase; Region: CoA_trans; cl17247 426117004232 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 426117004233 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117004234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004235 Cytochrome c; Region: Cytochrom_C; pfam00034 426117004236 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426117004237 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117004238 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 426117004239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117004240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004241 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 426117004242 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 426117004243 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426117004244 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 426117004245 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 426117004246 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 426117004247 homodimer interface [polypeptide binding]; other site 426117004248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117004249 catalytic residue [active] 426117004250 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 426117004251 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 426117004252 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 426117004253 TrkA-C domain; Region: TrkA_C; pfam02080 426117004254 TrkA-C domain; Region: TrkA_C; pfam02080 426117004255 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 426117004256 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426117004257 active site 426117004258 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426117004259 non-prolyl cis peptide bond; other site 426117004260 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426117004261 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426117004262 active site 426117004263 non-prolyl cis peptide bond; other site 426117004264 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426117004265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117004266 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 426117004267 active site 426117004268 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426117004269 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 426117004270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117004271 membrane-bound complex binding site; other site 426117004272 hinge residues; other site 426117004273 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 426117004274 ApbE family; Region: ApbE; pfam02424 426117004275 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426117004276 Flavodoxin; Region: Flavodoxin_1; pfam00258 426117004277 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 426117004278 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 426117004279 FAD binding pocket [chemical binding]; other site 426117004280 FAD binding motif [chemical binding]; other site 426117004281 catalytic residues [active] 426117004282 NAD binding pocket [chemical binding]; other site 426117004283 phosphate binding motif [ion binding]; other site 426117004284 beta-alpha-beta structure motif; other site 426117004285 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 426117004286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117004287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004288 dimer interface [polypeptide binding]; other site 426117004289 phosphorylation site [posttranslational modification] 426117004290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004291 Mg2+ binding site [ion binding]; other site 426117004292 G-X-G motif; other site 426117004293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117004294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004295 active site 426117004296 phosphorylation site [posttranslational modification] 426117004297 intermolecular recognition site; other site 426117004298 dimerization interface [polypeptide binding]; other site 426117004299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117004300 DNA binding site [nucleotide binding] 426117004301 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 426117004302 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 426117004303 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 426117004304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117004305 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 426117004306 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426117004307 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 426117004308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117004309 Ligand Binding Site [chemical binding]; other site 426117004310 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 426117004311 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 426117004312 general secretion pathway protein J; Validated; Region: PRK08808 426117004313 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 426117004314 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 426117004315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004316 dimer interface [polypeptide binding]; other site 426117004317 conserved gate region; other site 426117004318 putative PBP binding loops; other site 426117004319 ABC-ATPase subunit interface; other site 426117004320 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 426117004321 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 426117004322 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 426117004323 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 426117004324 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 426117004325 Caspase domain; Region: Peptidase_C14; pfam00656 426117004326 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117004327 Sel1-like repeats; Region: SEL1; smart00671 426117004328 Sel1-like repeats; Region: SEL1; smart00671 426117004329 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426117004330 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 426117004331 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 426117004332 Ligand binding site; other site 426117004333 oligomer interface; other site 426117004334 prephenate dehydratase; Provisional; Region: PRK11899 426117004335 Prephenate dehydratase; Region: PDT; pfam00800 426117004336 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 426117004337 putative L-Phe binding site [chemical binding]; other site 426117004338 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 426117004339 active site 426117004340 catalytic motif [active] 426117004341 Zn binding site [ion binding]; other site 426117004342 purine nucleoside phosphorylase; Provisional; Region: PRK08202 426117004343 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426117004344 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426117004345 inhibitor-cofactor binding pocket; inhibition site 426117004346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117004347 catalytic residue [active] 426117004348 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 426117004349 substrate binding site [chemical binding]; other site 426117004350 homodimer interface [polypeptide binding]; other site 426117004351 heme binding site [chemical binding]; other site 426117004352 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117004353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117004354 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 426117004355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117004356 substrate binding pocket [chemical binding]; other site 426117004357 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426117004358 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 426117004359 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 426117004360 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 426117004361 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 426117004362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117004363 substrate binding site [chemical binding]; other site 426117004364 ATP binding site [chemical binding]; other site 426117004365 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117004366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004367 dimer interface [polypeptide binding]; other site 426117004368 conserved gate region; other site 426117004369 putative PBP binding loops; other site 426117004370 ABC-ATPase subunit interface; other site 426117004371 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 426117004372 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 426117004373 Walker A/P-loop; other site 426117004374 ATP binding site [chemical binding]; other site 426117004375 Q-loop/lid; other site 426117004376 ABC transporter signature motif; other site 426117004377 Walker B; other site 426117004378 D-loop; other site 426117004379 H-loop/switch region; other site 426117004380 TOBE domain; Region: TOBE_2; pfam08402 426117004381 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117004382 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117004383 thiamine pyrophosphate protein; Validated; Region: PRK08199 426117004384 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117004385 PYR/PP interface [polypeptide binding]; other site 426117004386 dimer interface [polypeptide binding]; other site 426117004387 TPP binding site [chemical binding]; other site 426117004388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117004389 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 426117004390 TPP-binding site [chemical binding]; other site 426117004391 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 426117004392 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 426117004393 Creatinine amidohydrolase; Region: Creatininase; pfam02633 426117004394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117004395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117004396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004397 putative PBP binding loops; other site 426117004398 dimer interface [polypeptide binding]; other site 426117004399 ABC-ATPase subunit interface; other site 426117004400 PRC-barrel domain; Region: PRC; pfam05239 426117004401 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 426117004402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117004403 FAD binding site [chemical binding]; other site 426117004404 substrate binding pocket [chemical binding]; other site 426117004405 catalytic base [active] 426117004406 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426117004407 conserved cys residue [active] 426117004408 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426117004409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004411 urocanate hydratase; Provisional; Region: PRK05414 426117004412 N-formylglutamate amidohydrolase; Region: FGase; cl01522 426117004413 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 426117004414 active sites [active] 426117004415 tetramer interface [polypeptide binding]; other site 426117004416 imidazolonepropionase; Validated; Region: PRK09356 426117004417 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 426117004418 active site 426117004419 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 426117004420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117004421 active site 426117004422 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 426117004423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117004424 DNA-binding site [nucleotide binding]; DNA binding site 426117004425 UTRA domain; Region: UTRA; pfam07702 426117004426 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 426117004427 Predicted integral membrane protein [Function unknown]; Region: COG0392 426117004428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426117004429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004430 dimer interface [polypeptide binding]; other site 426117004431 phosphorylation site [posttranslational modification] 426117004432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004433 ATP binding site [chemical binding]; other site 426117004434 Mg2+ binding site [ion binding]; other site 426117004435 G-X-G motif; other site 426117004436 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 426117004437 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426117004438 metal-binding site [ion binding] 426117004439 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426117004440 metal-binding site [ion binding] 426117004441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426117004442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117004443 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426117004444 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426117004445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004446 PAS fold; Region: PAS_3; pfam08447 426117004447 putative active site [active] 426117004448 heme pocket [chemical binding]; other site 426117004449 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 426117004450 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117004451 Ligand Binding Site [chemical binding]; other site 426117004452 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 426117004453 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 426117004454 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 426117004455 putative NADH binding site [chemical binding]; other site 426117004456 putative active site [active] 426117004457 nudix motif; other site 426117004458 putative metal binding site [ion binding]; other site 426117004459 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 426117004460 nucleotide binding site/active site [active] 426117004461 HIT family signature motif; other site 426117004462 catalytic residue [active] 426117004463 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117004464 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117004465 ligand binding site [chemical binding]; other site 426117004466 flexible hinge region; other site 426117004467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117004468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426117004469 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426117004470 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 426117004471 active site 426117004472 Substrate binding site; other site 426117004473 Mg++ binding site; other site 426117004474 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 426117004475 putative ADP-binding pocket [chemical binding]; other site 426117004476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117004477 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 426117004478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426117004479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117004480 S-adenosylmethionine binding site [chemical binding]; other site 426117004481 camphor resistance protein CrcB; Provisional; Region: PRK14198 426117004482 Rdx family; Region: Rdx; cl01407 426117004483 PAS domain S-box; Region: sensory_box; TIGR00229 426117004484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004485 putative active site [active] 426117004486 heme pocket [chemical binding]; other site 426117004487 PAS fold; Region: PAS_3; pfam08447 426117004488 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426117004489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117004490 HWE histidine kinase; Region: HWE_HK; pfam07536 426117004491 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426117004492 active site 426117004493 amidase; Provisional; Region: PRK07486 426117004494 Amidase; Region: Amidase; cl11426 426117004495 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 426117004496 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 426117004497 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 426117004498 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 426117004499 putative active site [active] 426117004500 catalytic site [active] 426117004501 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 426117004502 putative active site [active] 426117004503 catalytic site [active] 426117004504 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 426117004505 putative catalytic site [active] 426117004506 putative metal binding site [ion binding]; other site 426117004507 putative phosphate binding site [ion binding]; other site 426117004508 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 426117004509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426117004510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426117004511 MAPEG family; Region: MAPEG; cl09190 426117004512 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 426117004513 putative heme binding pocket [chemical binding]; other site 426117004514 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 426117004515 active site 426117004516 catalytic site [active] 426117004517 substrate binding site [chemical binding]; other site 426117004518 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 426117004519 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 426117004520 nucleotide binding pocket [chemical binding]; other site 426117004521 K-X-D-G motif; other site 426117004522 catalytic site [active] 426117004523 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 426117004524 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 426117004525 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 426117004526 Dimer interface [polypeptide binding]; other site 426117004527 BRCT sequence motif; other site 426117004528 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117004529 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 426117004530 peptide binding site [polypeptide binding]; other site 426117004531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117004532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004533 dimer interface [polypeptide binding]; other site 426117004534 ABC-ATPase subunit interface; other site 426117004535 putative PBP binding loops; other site 426117004536 dipeptide transporter; Provisional; Region: PRK10913 426117004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004538 dimer interface [polypeptide binding]; other site 426117004539 conserved gate region; other site 426117004540 putative PBP binding loops; other site 426117004541 ABC-ATPase subunit interface; other site 426117004542 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 426117004543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117004544 Walker A/P-loop; other site 426117004545 ATP binding site [chemical binding]; other site 426117004546 Q-loop/lid; other site 426117004547 ABC transporter signature motif; other site 426117004548 Walker B; other site 426117004549 D-loop; other site 426117004550 H-loop/switch region; other site 426117004551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117004552 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426117004553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117004554 Walker A/P-loop; other site 426117004555 ATP binding site [chemical binding]; other site 426117004556 Q-loop/lid; other site 426117004557 ABC transporter signature motif; other site 426117004558 Walker B; other site 426117004559 D-loop; other site 426117004560 H-loop/switch region; other site 426117004561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117004562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117004563 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 426117004564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117004565 dimerization interface [polypeptide binding]; other site 426117004566 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 426117004567 putative active site [active] 426117004568 putative metal binding site [ion binding]; other site 426117004569 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 426117004570 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 426117004571 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 426117004572 generic binding surface II; other site 426117004573 generic binding surface I; other site 426117004574 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 426117004575 putative catalytic site [active] 426117004576 putative metal binding site [ion binding]; other site 426117004577 putative phosphate binding site [ion binding]; other site 426117004578 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 426117004579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117004580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117004581 Serine hydrolase (FSH1); Region: FSH1; pfam03959 426117004582 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117004583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117004584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117004585 acyl-activating enzyme (AAE) consensus motif; other site 426117004586 acyl-activating enzyme (AAE) consensus motif; other site 426117004587 AMP binding site [chemical binding]; other site 426117004588 active site 426117004589 CoA binding site [chemical binding]; other site 426117004590 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426117004591 Protein of unknown function (DUF975); Region: DUF975; cl10504 426117004592 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426117004593 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 426117004594 substrate binding site [chemical binding]; other site 426117004595 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426117004596 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 426117004597 putative active site [active] 426117004598 putative metal binding site [ion binding]; other site 426117004599 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426117004600 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 426117004601 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 426117004602 putative phosphoesterase; Region: acc_ester; TIGR03729 426117004603 short chain dehydrogenase; Provisional; Region: PRK06139 426117004604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117004605 NAD(P) binding site [chemical binding]; other site 426117004606 active site 426117004607 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117004608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117004609 substrate binding pocket [chemical binding]; other site 426117004610 membrane-bound complex binding site; other site 426117004611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117004612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117004613 Walker A/P-loop; other site 426117004614 ATP binding site [chemical binding]; other site 426117004615 Q-loop/lid; other site 426117004616 ABC transporter signature motif; other site 426117004617 Walker B; other site 426117004618 D-loop; other site 426117004619 H-loop/switch region; other site 426117004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004621 dimer interface [polypeptide binding]; other site 426117004622 conserved gate region; other site 426117004623 putative PBP binding loops; other site 426117004624 ABC-ATPase subunit interface; other site 426117004625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004626 dimer interface [polypeptide binding]; other site 426117004627 conserved gate region; other site 426117004628 putative PBP binding loops; other site 426117004629 ABC-ATPase subunit interface; other site 426117004630 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 426117004631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117004632 NAD(P) binding site [chemical binding]; other site 426117004633 active site 426117004634 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 426117004635 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117004636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117004637 DNA-binding site [nucleotide binding]; DNA binding site 426117004638 FCD domain; Region: FCD; pfam07729 426117004639 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426117004640 Helix-turn-helix domain; Region: HTH_18; pfam12833 426117004641 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426117004642 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426117004643 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426117004644 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426117004645 Walker A/P-loop; other site 426117004646 ATP binding site [chemical binding]; other site 426117004647 Q-loop/lid; other site 426117004648 ABC transporter signature motif; other site 426117004649 Walker B; other site 426117004650 D-loop; other site 426117004651 H-loop/switch region; other site 426117004652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117004653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117004654 DNA binding residues [nucleotide binding] 426117004655 dimerization interface [polypeptide binding]; other site 426117004656 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426117004657 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117004658 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117004659 protein binding site [polypeptide binding]; other site 426117004660 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426117004661 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117004662 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117004663 protein binding site [polypeptide binding]; other site 426117004664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117004665 protein binding site [polypeptide binding]; other site 426117004666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117004667 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117004668 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117004669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117004670 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117004671 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117004672 Integrase core domain; Region: rve; pfam00665 426117004673 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 426117004674 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 426117004675 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 426117004676 Family of unknown function (DUF694); Region: DUF694; pfam05107 426117004677 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 426117004678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117004679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117004680 dimerization interface [polypeptide binding]; other site 426117004681 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117004682 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117004683 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117004684 classical (c) SDRs; Region: SDR_c; cd05233 426117004685 NAD(P) binding site [chemical binding]; other site 426117004686 active site 426117004687 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 426117004688 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 426117004689 dimer interface [polypeptide binding]; other site 426117004690 active site 426117004691 catalytic residue [active] 426117004692 metal binding site [ion binding]; metal-binding site 426117004693 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 426117004694 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426117004695 classical (c) SDRs; Region: SDR_c; cd05233 426117004696 NAD(P) binding site [chemical binding]; other site 426117004697 active site 426117004698 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117004699 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117004700 haloalkane dehalogenase; Provisional; Region: PRK03592 426117004701 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426117004702 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 426117004703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117004704 TAP-like protein; Region: Abhydrolase_4; pfam08386 426117004705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426117004706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117004707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117004708 Walker A/P-loop; other site 426117004709 ATP binding site [chemical binding]; other site 426117004710 Q-loop/lid; other site 426117004711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117004712 ABC transporter signature motif; other site 426117004713 Walker B; other site 426117004714 D-loop; other site 426117004715 ABC transporter; Region: ABC_tran_2; pfam12848 426117004716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117004717 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 426117004718 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117004719 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117004720 Walker A/P-loop; other site 426117004721 ATP binding site [chemical binding]; other site 426117004722 Q-loop/lid; other site 426117004723 ABC transporter signature motif; other site 426117004724 Walker B; other site 426117004725 D-loop; other site 426117004726 H-loop/switch region; other site 426117004727 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117004728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117004729 substrate binding pocket [chemical binding]; other site 426117004730 membrane-bound complex binding site; other site 426117004731 hinge residues; other site 426117004732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004733 dimer interface [polypeptide binding]; other site 426117004734 conserved gate region; other site 426117004735 putative PBP binding loops; other site 426117004736 ABC-ATPase subunit interface; other site 426117004737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117004739 dimer interface [polypeptide binding]; other site 426117004740 conserved gate region; other site 426117004741 ABC-ATPase subunit interface; other site 426117004742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117004743 Coenzyme A binding pocket [chemical binding]; other site 426117004744 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 426117004745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117004746 S-adenosylmethionine binding site [chemical binding]; other site 426117004747 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 426117004748 putative trimer interface [polypeptide binding]; other site 426117004749 putative CoA binding site [chemical binding]; other site 426117004750 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 426117004751 trimer interface [polypeptide binding]; other site 426117004752 putative metal binding site [ion binding]; other site 426117004753 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 426117004754 MoaE homodimer interface [polypeptide binding]; other site 426117004755 MoaD interaction [polypeptide binding]; other site 426117004756 active site residues [active] 426117004757 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 426117004758 dihydroorotase; Validated; Region: PRK09060 426117004759 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 426117004760 active site 426117004761 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 426117004762 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 426117004763 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 426117004764 putative deacylase active site [active] 426117004765 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 426117004766 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426117004767 NAD binding site [chemical binding]; other site 426117004768 homotetramer interface [polypeptide binding]; other site 426117004769 homodimer interface [polypeptide binding]; other site 426117004770 substrate binding site [chemical binding]; other site 426117004771 active site 426117004772 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 426117004773 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 426117004774 active site 426117004775 ADP/pyrophosphate binding site [chemical binding]; other site 426117004776 allosteric effector site; other site 426117004777 fructose-1,6-bisphosphate binding site; other site 426117004778 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 426117004779 Cysteine-rich domain; Region: CCG; pfam02754 426117004780 Cysteine-rich domain; Region: CCG; pfam02754 426117004781 SOUL heme-binding protein; Region: SOUL; pfam04832 426117004782 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 426117004783 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 426117004784 FAD binding domain; Region: FAD_binding_4; pfam01565 426117004785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426117004786 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426117004787 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 426117004788 Cl binding site [ion binding]; other site 426117004789 oligomer interface [polypeptide binding]; other site 426117004790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 426117004791 oligomerisation interface [polypeptide binding]; other site 426117004792 mobile loop; other site 426117004793 roof hairpin; other site 426117004794 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 426117004795 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 426117004796 ring oligomerisation interface [polypeptide binding]; other site 426117004797 ATP/Mg binding site [chemical binding]; other site 426117004798 stacking interactions; other site 426117004799 hinge regions; other site 426117004800 enoyl-CoA hydratase; Provisional; Region: PRK06144 426117004801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117004802 substrate binding site [chemical binding]; other site 426117004803 oxyanion hole (OAH) forming residues; other site 426117004804 trimer interface [polypeptide binding]; other site 426117004805 PAS domain S-box; Region: sensory_box; TIGR00229 426117004806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004807 putative active site [active] 426117004808 heme pocket [chemical binding]; other site 426117004809 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117004810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117004811 metal binding site [ion binding]; metal-binding site 426117004812 active site 426117004813 I-site; other site 426117004814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004815 putative active site [active] 426117004816 heme pocket [chemical binding]; other site 426117004817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117004818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004819 dimer interface [polypeptide binding]; other site 426117004820 phosphorylation site [posttranslational modification] 426117004821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004822 ATP binding site [chemical binding]; other site 426117004823 Mg2+ binding site [ion binding]; other site 426117004824 G-X-G motif; other site 426117004825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426117004826 metal-binding site [ion binding] 426117004827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117004828 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 426117004829 Cytochrome C' Region: Cytochrom_C_2; pfam01322 426117004830 HAMP domain; Region: HAMP; pfam00672 426117004831 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 426117004832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117004833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117004834 metal binding site [ion binding]; metal-binding site 426117004835 active site 426117004836 I-site; other site 426117004837 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 426117004838 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117004839 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117004840 putative ligand binding site [chemical binding]; other site 426117004841 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 426117004842 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 426117004843 SEC-C motif; Region: SEC-C; pfam02810 426117004844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 426117004845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117004846 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117004847 Walker A/P-loop; other site 426117004848 ATP binding site [chemical binding]; other site 426117004849 Q-loop/lid; other site 426117004850 ABC transporter signature motif; other site 426117004851 Walker B; other site 426117004852 D-loop; other site 426117004853 H-loop/switch region; other site 426117004854 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117004855 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117004856 TM-ABC transporter signature motif; other site 426117004857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117004858 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117004859 Walker A/P-loop; other site 426117004860 ATP binding site [chemical binding]; other site 426117004861 Q-loop/lid; other site 426117004862 ABC transporter signature motif; other site 426117004863 Walker B; other site 426117004864 D-loop; other site 426117004865 H-loop/switch region; other site 426117004866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117004867 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117004868 TM-ABC transporter signature motif; other site 426117004869 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117004870 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 426117004871 putative ligand binding site [chemical binding]; other site 426117004872 Helix-turn-helix domain; Region: HTH_20; pfam12840 426117004873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117004874 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 426117004875 putative hydrophobic ligand binding site [chemical binding]; other site 426117004876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117004877 classical (c) SDRs; Region: SDR_c; cd05233 426117004878 NAD(P) binding site [chemical binding]; other site 426117004879 active site 426117004880 Cupin domain; Region: Cupin_2; cl17218 426117004881 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 426117004882 active site 426117004883 tetramer interface; other site 426117004884 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 426117004885 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 426117004886 NAD binding site [chemical binding]; other site 426117004887 homodimer interface [polypeptide binding]; other site 426117004888 active site 426117004889 substrate binding site [chemical binding]; other site 426117004890 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426117004891 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117004892 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117004893 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117004894 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 426117004895 active site 426117004896 catalytic triad [active] 426117004897 oxyanion hole [active] 426117004898 PAS fold; Region: PAS_4; pfam08448 426117004899 PAS fold; Region: PAS_4; pfam08448 426117004900 PAS domain; Region: PAS_9; pfam13426 426117004901 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426117004902 PAS fold; Region: PAS_3; pfam08447 426117004903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004904 putative active site [active] 426117004905 heme pocket [chemical binding]; other site 426117004906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117004908 dimer interface [polypeptide binding]; other site 426117004909 phosphorylation site [posttranslational modification] 426117004910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004911 ATP binding site [chemical binding]; other site 426117004912 Mg2+ binding site [ion binding]; other site 426117004913 G-X-G motif; other site 426117004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004915 Response regulator receiver domain; Region: Response_reg; pfam00072 426117004916 active site 426117004917 phosphorylation site [posttranslational modification] 426117004918 intermolecular recognition site; other site 426117004919 dimerization interface [polypeptide binding]; other site 426117004920 Protein of unknown function, DUF599; Region: DUF599; pfam04654 426117004921 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 426117004922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117004923 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 426117004924 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 426117004925 active site 426117004926 dimer interface [polypeptide binding]; other site 426117004927 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 426117004928 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 426117004929 active site 426117004930 FMN binding site [chemical binding]; other site 426117004931 substrate binding site [chemical binding]; other site 426117004932 3Fe-4S cluster binding site [ion binding]; other site 426117004933 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 426117004934 domain interface; other site 426117004935 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 426117004936 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117004937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117004938 catalytic residue [active] 426117004939 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 426117004940 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 426117004941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117004942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117004943 PAS domain; Region: PAS_9; pfam13426 426117004944 putative active site [active] 426117004945 heme pocket [chemical binding]; other site 426117004946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117004947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117004948 dimer interface [polypeptide binding]; other site 426117004949 putative CheW interface [polypeptide binding]; other site 426117004950 Domain of unknown function (DUF305); Region: DUF305; pfam03713 426117004951 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 426117004952 dimanganese center [ion binding]; other site 426117004953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117004954 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 426117004955 putative DNA binding site [nucleotide binding]; other site 426117004956 putative Zn2+ binding site [ion binding]; other site 426117004957 AsnC family; Region: AsnC_trans_reg; pfam01037 426117004958 agmatinase; Region: agmatinase; TIGR01230 426117004959 Arginase family; Region: Arginase; cd09989 426117004960 active site 426117004961 Mn binding site [ion binding]; other site 426117004962 oligomer interface [polypeptide binding]; other site 426117004963 ornithine cyclodeaminase; Validated; Region: PRK07589 426117004964 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 426117004965 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117004966 metal binding site [ion binding]; metal-binding site 426117004967 active site 426117004968 I-site; other site 426117004969 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117004970 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426117004971 RNA polymerase sigma factor; Provisional; Region: PRK12546 426117004972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117004973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117004974 DNA binding residues [nucleotide binding] 426117004975 PAS fold; Region: PAS_4; pfam08448 426117004976 PAS domain; Region: PAS; smart00091 426117004977 PAS fold; Region: PAS_4; pfam08448 426117004978 PAS fold; Region: PAS_4; pfam08448 426117004979 PAS domain S-box; Region: sensory_box; TIGR00229 426117004980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117004981 dimer interface [polypeptide binding]; other site 426117004982 phosphorylation site [posttranslational modification] 426117004983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117004984 ATP binding site [chemical binding]; other site 426117004985 Mg2+ binding site [ion binding]; other site 426117004986 G-X-G motif; other site 426117004987 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117004988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117004989 active site 426117004990 phosphorylation site [posttranslational modification] 426117004991 intermolecular recognition site; other site 426117004992 dimerization interface [polypeptide binding]; other site 426117004993 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117004994 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426117004995 C-terminal domain interface [polypeptide binding]; other site 426117004996 GSH binding site (G-site) [chemical binding]; other site 426117004997 dimer interface [polypeptide binding]; other site 426117004998 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426117004999 N-terminal domain interface [polypeptide binding]; other site 426117005000 dimer interface [polypeptide binding]; other site 426117005001 substrate binding pocket (H-site) [chemical binding]; other site 426117005002 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117005003 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117005004 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117005005 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117005006 ligand binding site [chemical binding]; other site 426117005007 flexible hinge region; other site 426117005008 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117005009 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117005010 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117005011 ligand binding site [chemical binding]; other site 426117005012 flexible hinge region; other site 426117005013 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117005014 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 426117005015 allantoate amidohydrolase; Reviewed; Region: PRK09290 426117005016 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426117005017 active site 426117005018 metal binding site [ion binding]; metal-binding site 426117005019 dimer interface [polypeptide binding]; other site 426117005020 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117005021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117005022 DNA-binding site [nucleotide binding]; DNA binding site 426117005023 FCD domain; Region: FCD; pfam07729 426117005024 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117005025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005026 putative substrate translocation pore; other site 426117005027 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117005028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117005029 PAS fold; Region: PAS_7; pfam12860 426117005030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117005031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117005032 metal binding site [ion binding]; metal-binding site 426117005033 active site 426117005034 I-site; other site 426117005035 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117005036 Isochorismatase family; Region: Isochorismatase; pfam00857 426117005037 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 426117005038 catalytic triad [active] 426117005039 conserved cis-peptide bond; other site 426117005040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426117005041 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117005042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117005043 Magnesium ion binding site [ion binding]; other site 426117005044 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 426117005045 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 426117005046 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 426117005047 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 426117005048 LrgB-like family; Region: LrgB; pfam04172 426117005049 LrgA family; Region: LrgA; cl00608 426117005050 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 426117005051 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 426117005052 catalytic triad [active] 426117005053 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 426117005054 putative metal binding site [ion binding]; other site 426117005055 CsbD-like; Region: CsbD; pfam05532 426117005056 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117005057 MULE transposase domain; Region: MULE; pfam10551 426117005058 DDE domain; Region: DDE_Tnp_IS240; pfam13610 426117005059 Integrase core domain; Region: rve; pfam00665 426117005060 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 426117005061 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 426117005062 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117005063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005064 putative substrate translocation pore; other site 426117005065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005066 DDE domain; Region: DDE_Tnp_IS240; pfam13610 426117005067 Integrase core domain; Region: rve; pfam00665 426117005068 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117005069 AAA domain; Region: AAA_33; pfam13671 426117005070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 426117005071 active site 426117005072 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117005073 DDE domain; Region: DDE_Tnp_IS240; pfam13610 426117005074 Integrase core domain; Region: rve; pfam00665 426117005075 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117005076 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117005077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117005078 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426117005079 catalytic site [active] 426117005080 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117005081 MULE transposase domain; Region: MULE; pfam10551 426117005082 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117005083 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117005084 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117005085 catalytic residue [active] 426117005086 Sporulation related domain; Region: SPOR; pfam05036 426117005087 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426117005088 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 426117005089 oligomer interface [polypeptide binding]; other site 426117005090 metal binding site [ion binding]; metal-binding site 426117005091 metal binding site [ion binding]; metal-binding site 426117005092 putative Cl binding site [ion binding]; other site 426117005093 basic sphincter; other site 426117005094 hydrophobic gate; other site 426117005095 periplasmic entrance; other site 426117005096 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 426117005097 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 426117005098 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 426117005099 Integrase core domain; Region: rve_3; pfam13683 426117005100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117005101 Transposase; Region: HTH_Tnp_1; pfam01527 426117005102 Predicted permeases [General function prediction only]; Region: COG0679 426117005103 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 426117005104 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117005105 PYR/PP interface [polypeptide binding]; other site 426117005106 dimer interface [polypeptide binding]; other site 426117005107 TPP binding site [chemical binding]; other site 426117005108 benzoate transport; Region: 2A0115; TIGR00895 426117005109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005110 putative substrate translocation pore; other site 426117005111 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 426117005112 active site 426117005113 catalytic residues [active] 426117005114 metal binding site [ion binding]; metal-binding site 426117005115 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117005116 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117005117 aconitate hydratase; Validated; Region: PRK07229 426117005118 aconitate hydratase; Validated; Region: PRK07229 426117005119 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426117005120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117005121 DNA-binding site [nucleotide binding]; DNA binding site 426117005122 UTRA domain; Region: UTRA; pfam07702 426117005123 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117005124 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117005125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117005126 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117005127 TM-ABC transporter signature motif; other site 426117005128 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117005129 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117005130 TM-ABC transporter signature motif; other site 426117005131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117005132 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117005133 Walker A/P-loop; other site 426117005134 ATP binding site [chemical binding]; other site 426117005135 Q-loop/lid; other site 426117005136 ABC transporter signature motif; other site 426117005137 Walker B; other site 426117005138 D-loop; other site 426117005139 H-loop/switch region; other site 426117005140 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117005141 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117005142 Walker A/P-loop; other site 426117005143 ATP binding site [chemical binding]; other site 426117005144 Q-loop/lid; other site 426117005145 ABC transporter signature motif; other site 426117005146 Walker B; other site 426117005147 D-loop; other site 426117005148 H-loop/switch region; other site 426117005149 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 426117005150 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 426117005151 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 426117005152 tetramer interface [polypeptide binding]; other site 426117005153 active site 426117005154 Mg2+/Mn2+ binding site [ion binding]; other site 426117005155 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 426117005156 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 426117005157 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 426117005158 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 426117005159 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 426117005160 Isochorismatase family; Region: Isochorismatase; pfam00857 426117005161 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426117005162 catalytic triad [active] 426117005163 conserved cis-peptide bond; other site 426117005164 FAD binding domain; Region: FAD_binding_2; pfam00890 426117005165 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 426117005166 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 426117005167 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 426117005168 substrate binding site [chemical binding]; other site 426117005169 ligand binding site [chemical binding]; other site 426117005170 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 426117005171 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 426117005172 substrate binding site [chemical binding]; other site 426117005173 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 426117005174 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 426117005175 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 426117005176 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 426117005177 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 426117005178 active site 426117005179 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117005180 Family description; Region: VCBS; pfam13517 426117005181 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 426117005182 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426117005183 tyrosine decarboxylase; Region: PLN02880 426117005184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117005185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117005186 catalytic residue [active] 426117005187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117005188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117005189 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117005190 putative effector binding pocket; other site 426117005191 dimerization interface [polypeptide binding]; other site 426117005192 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 426117005193 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117005194 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 426117005195 active site 426117005196 dimer interface [polypeptide binding]; other site 426117005197 metal binding site [ion binding]; metal-binding site 426117005198 benzoate transport; Region: 2A0115; TIGR00895 426117005199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005200 putative substrate translocation pore; other site 426117005201 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117005202 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117005203 YciI-like protein; Reviewed; Region: PRK12863 426117005204 Pirin-related protein [General function prediction only]; Region: COG1741 426117005205 Pirin; Region: Pirin; pfam02678 426117005206 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 426117005207 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 426117005208 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 426117005209 N- and C-terminal domain interface [polypeptide binding]; other site 426117005210 active site 426117005211 MgATP binding site [chemical binding]; other site 426117005212 catalytic site [active] 426117005213 metal binding site [ion binding]; metal-binding site 426117005214 glycerol binding site [chemical binding]; other site 426117005215 homotetramer interface [polypeptide binding]; other site 426117005216 homodimer interface [polypeptide binding]; other site 426117005217 FBP binding site [chemical binding]; other site 426117005218 protein IIAGlc interface [polypeptide binding]; other site 426117005219 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 426117005220 putative active site [active] 426117005221 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 426117005222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117005223 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 426117005224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117005225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117005226 dimer interface [polypeptide binding]; other site 426117005227 conserved gate region; other site 426117005228 putative PBP binding loops; other site 426117005229 ABC-ATPase subunit interface; other site 426117005230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117005231 dimer interface [polypeptide binding]; other site 426117005232 conserved gate region; other site 426117005233 putative PBP binding loops; other site 426117005234 ABC-ATPase subunit interface; other site 426117005235 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 426117005236 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 426117005237 Walker A/P-loop; other site 426117005238 ATP binding site [chemical binding]; other site 426117005239 Q-loop/lid; other site 426117005240 ABC transporter signature motif; other site 426117005241 Walker B; other site 426117005242 D-loop; other site 426117005243 H-loop/switch region; other site 426117005244 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 426117005245 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 426117005246 Walker A/P-loop; other site 426117005247 ATP binding site [chemical binding]; other site 426117005248 Q-loop/lid; other site 426117005249 ABC transporter signature motif; other site 426117005250 Walker B; other site 426117005251 D-loop; other site 426117005252 H-loop/switch region; other site 426117005253 TOBE domain; Region: TOBE_2; pfam08402 426117005254 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 426117005255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117005256 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117005257 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 426117005258 putative ligand binding site [chemical binding]; other site 426117005259 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117005260 TM-ABC transporter signature motif; other site 426117005261 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117005262 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117005263 TM-ABC transporter signature motif; other site 426117005264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117005265 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117005266 Walker A/P-loop; other site 426117005267 ATP binding site [chemical binding]; other site 426117005268 Q-loop/lid; other site 426117005269 ABC transporter signature motif; other site 426117005270 Walker B; other site 426117005271 D-loop; other site 426117005272 H-loop/switch region; other site 426117005273 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117005274 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117005275 Walker A/P-loop; other site 426117005276 ATP binding site [chemical binding]; other site 426117005277 Q-loop/lid; other site 426117005278 ABC transporter signature motif; other site 426117005279 Walker B; other site 426117005280 D-loop; other site 426117005281 H-loop/switch region; other site 426117005282 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 426117005283 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 426117005284 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 426117005285 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 426117005286 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 426117005287 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426117005288 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 426117005289 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 426117005290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117005291 catalytic loop [active] 426117005292 iron binding site [ion binding]; other site 426117005293 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117005294 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117005295 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117005296 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 426117005297 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117005298 MarR family; Region: MarR; pfam01047 426117005299 hypothetical protein; Provisional; Region: PRK04334 426117005300 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117005301 Sel1-like repeats; Region: SEL1; smart00671 426117005302 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117005303 Sel1-like repeats; Region: SEL1; smart00671 426117005304 stage V sporulation protein K; Region: spore_V_K; TIGR02881 426117005305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117005306 Walker A motif; other site 426117005307 ATP binding site [chemical binding]; other site 426117005308 Walker B motif; other site 426117005309 arginine finger; other site 426117005310 stage V sporulation protein K; Region: spore_V_K; TIGR02881 426117005311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117005312 Walker A motif; other site 426117005313 ATP binding site [chemical binding]; other site 426117005314 Walker B motif; other site 426117005315 arginine finger; other site 426117005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117005318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005319 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 426117005320 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 426117005321 transmembrane helices; other site 426117005322 PAS fold; Region: PAS_7; pfam12860 426117005323 PAS fold; Region: PAS_7; pfam12860 426117005324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117005325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117005326 metal binding site [ion binding]; metal-binding site 426117005327 active site 426117005328 I-site; other site 426117005329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117005330 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426117005331 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 426117005332 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 426117005333 putative active site [active] 426117005334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 426117005335 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 426117005336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117005337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005338 dimer interface [polypeptide binding]; other site 426117005339 phosphorylation site [posttranslational modification] 426117005340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005341 ATP binding site [chemical binding]; other site 426117005342 Mg2+ binding site [ion binding]; other site 426117005343 G-X-G motif; other site 426117005344 osmolarity response regulator; Provisional; Region: ompR; PRK09468 426117005345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005346 active site 426117005347 phosphorylation site [posttranslational modification] 426117005348 intermolecular recognition site; other site 426117005349 dimerization interface [polypeptide binding]; other site 426117005350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117005351 DNA binding site [nucleotide binding] 426117005352 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 426117005353 hypothetical protein; Validated; Region: PRK07198 426117005354 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 426117005355 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 426117005356 dimerization interface [polypeptide binding]; other site 426117005357 active site 426117005358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117005359 active site 426117005360 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 426117005361 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 426117005362 NAD(P) binding site [chemical binding]; other site 426117005363 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 426117005364 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117005365 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117005366 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 426117005367 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 426117005368 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 426117005369 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 426117005370 Ligand binding site [chemical binding]; other site 426117005371 Electron transfer flavoprotein domain; Region: ETF; pfam01012 426117005372 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 426117005373 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 426117005374 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 426117005375 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 426117005376 Cl binding site [ion binding]; other site 426117005377 oligomer interface [polypeptide binding]; other site 426117005378 Phosphate transporter family; Region: PHO4; pfam01384 426117005379 Phosphate transporter family; Region: PHO4; cl00396 426117005380 amino acid transporter; Region: 2A0306; TIGR00909 426117005381 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 426117005382 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 426117005383 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 426117005384 Uncharacterized conserved protein [Function unknown]; Region: COG4278 426117005385 TIGR04222 domain; Region: near_uncomplex 426117005386 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 426117005387 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 426117005388 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 426117005389 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426117005390 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426117005391 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 426117005392 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 426117005393 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 426117005394 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 426117005395 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 426117005396 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 426117005397 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 426117005398 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 426117005399 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117005400 Walker A motif; other site 426117005401 ATP binding site [chemical binding]; other site 426117005402 Walker B motif; other site 426117005403 Domain of unknown function (DUF336); Region: DUF336; cl01249 426117005404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117005405 S-adenosylmethionine binding site [chemical binding]; other site 426117005406 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426117005407 active site 426117005408 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426117005409 FAD binding domain; Region: FAD_binding_4; pfam01565 426117005410 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 426117005411 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117005412 Dienelactone hydrolase family; Region: DLH; pfam01738 426117005413 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117005414 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 426117005415 gating phenylalanine in ion channel; other site 426117005416 PAS domain; Region: PAS; smart00091 426117005417 PAS domain; Region: PAS_9; pfam13426 426117005418 putative active site [active] 426117005419 heme pocket [chemical binding]; other site 426117005420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005421 PAS fold; Region: PAS_3; pfam08447 426117005422 putative active site [active] 426117005423 heme pocket [chemical binding]; other site 426117005424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117005426 dimer interface [polypeptide binding]; other site 426117005427 phosphorylation site [posttranslational modification] 426117005428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005429 ATP binding site [chemical binding]; other site 426117005430 Mg2+ binding site [ion binding]; other site 426117005431 G-X-G motif; other site 426117005432 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005434 active site 426117005435 phosphorylation site [posttranslational modification] 426117005436 intermolecular recognition site; other site 426117005437 dimerization interface [polypeptide binding]; other site 426117005438 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 426117005439 Chemotaxis phosphatase CheX; Region: CheX; cl15816 426117005440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005441 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005442 active site 426117005443 phosphorylation site [posttranslational modification] 426117005444 intermolecular recognition site; other site 426117005445 dimerization interface [polypeptide binding]; other site 426117005446 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426117005447 putative binding surface; other site 426117005448 active site 426117005449 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 426117005450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005451 ATP binding site [chemical binding]; other site 426117005452 Mg2+ binding site [ion binding]; other site 426117005453 G-X-G motif; other site 426117005454 CheW-like domain; Region: CheW; pfam01584 426117005455 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005457 active site 426117005458 phosphorylation site [posttranslational modification] 426117005459 intermolecular recognition site; other site 426117005460 dimerization interface [polypeptide binding]; other site 426117005461 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426117005462 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426117005463 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426117005464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005465 active site 426117005466 phosphorylation site [posttranslational modification] 426117005467 intermolecular recognition site; other site 426117005468 dimerization interface [polypeptide binding]; other site 426117005469 CheB methylesterase; Region: CheB_methylest; pfam01339 426117005470 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426117005471 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426117005472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117005473 dimer interface [polypeptide binding]; other site 426117005474 putative CheW interface [polypeptide binding]; other site 426117005475 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117005476 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426117005477 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426117005478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005479 PAS domain; Region: PAS_9; pfam13426 426117005480 putative active site [active] 426117005481 heme pocket [chemical binding]; other site 426117005482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005483 dimer interface [polypeptide binding]; other site 426117005484 phosphorylation site [posttranslational modification] 426117005485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005486 ATP binding site [chemical binding]; other site 426117005487 G-X-G motif; other site 426117005488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005489 active site 426117005490 phosphorylation site [posttranslational modification] 426117005491 intermolecular recognition site; other site 426117005492 dimerization interface [polypeptide binding]; other site 426117005493 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 426117005494 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 426117005495 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426117005496 aromatic amino acid exporter; Provisional; Region: PRK11689 426117005497 EamA-like transporter family; Region: EamA; pfam00892 426117005498 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 426117005499 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 426117005500 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117005501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117005502 MarC family integral membrane protein; Region: MarC; cl00919 426117005503 dihydrodipicolinate reductase; Provisional; Region: PRK00048 426117005504 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 426117005505 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 426117005506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117005507 catalytic core [active] 426117005508 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 426117005509 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 426117005510 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 426117005511 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 426117005512 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117005513 NAD binding site [chemical binding]; other site 426117005514 putative substrate binding site 2 [chemical binding]; other site 426117005515 putative substrate binding site 1 [chemical binding]; other site 426117005516 active site 426117005517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426117005518 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426117005519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426117005520 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426117005521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426117005522 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426117005523 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117005524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117005525 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 426117005526 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426117005527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117005528 FeS/SAM binding site; other site 426117005529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117005530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117005531 NAD(P) binding site [chemical binding]; other site 426117005532 active site 426117005533 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117005534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117005535 NAD(P) binding site [chemical binding]; other site 426117005536 active site 426117005537 lytic murein transglycosylase; Region: MltB_2; TIGR02283 426117005538 murein hydrolase B; Provisional; Region: PRK10760; cl17906 426117005539 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 426117005540 GAF domain; Region: GAF; pfam01590 426117005541 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117005542 PAS domain S-box; Region: sensory_box; TIGR00229 426117005543 PAS domain; Region: PAS_8; pfam13188 426117005544 PAS fold; Region: PAS_4; pfam08448 426117005545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005546 putative active site [active] 426117005547 heme pocket [chemical binding]; other site 426117005548 PAS domain S-box; Region: sensory_box; TIGR00229 426117005549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005550 putative active site [active] 426117005551 heme pocket [chemical binding]; other site 426117005552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005553 ATP binding site [chemical binding]; other site 426117005554 Mg2+ binding site [ion binding]; other site 426117005555 G-X-G motif; other site 426117005556 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005558 active site 426117005559 phosphorylation site [posttranslational modification] 426117005560 intermolecular recognition site; other site 426117005561 dimerization interface [polypeptide binding]; other site 426117005562 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426117005563 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426117005564 Trp docking motif [polypeptide binding]; other site 426117005565 dimer interface [polypeptide binding]; other site 426117005566 active site 426117005567 small subunit binding site [polypeptide binding]; other site 426117005568 short chain dehydrogenase; Provisional; Region: PRK07109 426117005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117005570 NAD(P) binding site [chemical binding]; other site 426117005571 active site 426117005572 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 426117005573 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426117005574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117005575 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426117005576 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 426117005577 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 426117005578 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 426117005579 metal binding site [ion binding]; metal-binding site 426117005580 substrate binding pocket [chemical binding]; other site 426117005581 thiamine pyrophosphate protein; Provisional; Region: PRK08273 426117005582 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 426117005583 PYR/PP interface [polypeptide binding]; other site 426117005584 dimer interface [polypeptide binding]; other site 426117005585 tetramer interface [polypeptide binding]; other site 426117005586 TPP binding site [chemical binding]; other site 426117005587 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117005588 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 426117005589 TPP-binding site [chemical binding]; other site 426117005590 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426117005591 active site 426117005592 catalytic triad [active] 426117005593 oxyanion hole [active] 426117005594 CHASE3 domain; Region: CHASE3; pfam05227 426117005595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117005596 dimer interface [polypeptide binding]; other site 426117005597 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426117005598 putative CheW interface [polypeptide binding]; other site 426117005599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 426117005600 Autotransporter beta-domain; Region: Autotransporter; smart00869 426117005601 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 426117005602 putative active site pocket [active] 426117005603 cleavage site 426117005604 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117005605 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117005606 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117005607 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 426117005608 Protein export membrane protein; Region: SecD_SecF; cl14618 426117005609 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 426117005610 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 426117005611 nudix motif; other site 426117005612 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 426117005613 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 426117005614 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 426117005615 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426117005616 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 426117005617 HSP70 interaction site [polypeptide binding]; other site 426117005618 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 426117005619 substrate binding site [polypeptide binding]; other site 426117005620 dimer interface [polypeptide binding]; other site 426117005621 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 426117005622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 426117005623 Amino acid synthesis; Region: AA_synth; pfam06684 426117005624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117005625 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426117005626 RNA binding surface [nucleotide binding]; other site 426117005627 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 426117005628 active site 426117005629 uracil binding [chemical binding]; other site 426117005630 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 426117005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117005632 S-adenosylmethionine binding site [chemical binding]; other site 426117005633 PAS domain; Region: PAS; smart00091 426117005634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117005635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005636 dimer interface [polypeptide binding]; other site 426117005637 phosphorylation site [posttranslational modification] 426117005638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005639 active site 426117005640 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005641 phosphorylation site [posttranslational modification] 426117005642 intermolecular recognition site; other site 426117005643 dimerization interface [polypeptide binding]; other site 426117005644 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 426117005645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117005646 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117005647 active site 426117005648 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 426117005649 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 426117005650 WHG domain; Region: WHG; pfam13305 426117005651 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 426117005652 ArgK protein; Region: ArgK; pfam03308 426117005653 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 426117005654 Walker A; other site 426117005655 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 426117005656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117005658 S-adenosylmethionine binding site [chemical binding]; other site 426117005659 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117005660 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426117005661 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426117005662 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 426117005663 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 426117005664 UreF; Region: UreF; pfam01730 426117005665 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 426117005666 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426117005667 dimer interface [polypeptide binding]; other site 426117005668 catalytic residues [active] 426117005669 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 426117005670 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117005671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117005672 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117005673 putative DNA binding site [nucleotide binding]; other site 426117005674 putative Zn2+ binding site [ion binding]; other site 426117005675 AsnC family; Region: AsnC_trans_reg; pfam01037 426117005676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117005677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117005678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117005679 dimerization interface [polypeptide binding]; other site 426117005680 hypothetical protein; Provisional; Region: PRK05463 426117005681 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117005682 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 426117005683 putative ligand binding site [chemical binding]; other site 426117005684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117005685 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117005686 TM-ABC transporter signature motif; other site 426117005687 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117005688 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117005689 TM-ABC transporter signature motif; other site 426117005690 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117005691 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117005692 Walker A/P-loop; other site 426117005693 ATP binding site [chemical binding]; other site 426117005694 Q-loop/lid; other site 426117005695 ABC transporter signature motif; other site 426117005696 Walker B; other site 426117005697 D-loop; other site 426117005698 H-loop/switch region; other site 426117005699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117005700 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117005701 Walker A/P-loop; other site 426117005702 ATP binding site [chemical binding]; other site 426117005703 Q-loop/lid; other site 426117005704 ABC transporter signature motif; other site 426117005705 Walker B; other site 426117005706 D-loop; other site 426117005707 H-loop/switch region; other site 426117005708 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 426117005709 putative active site [active] 426117005710 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 426117005711 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 426117005712 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 426117005713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117005714 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 426117005715 putative substrate translocation pore; other site 426117005716 PilZ domain; Region: PilZ; cl01260 426117005717 Predicted membrane protein [Function unknown]; Region: COG2259 426117005718 DHHW protein; Region: DHHW; pfam14286 426117005719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005720 PAS fold; Region: PAS_3; pfam08447 426117005721 putative active site [active] 426117005722 heme pocket [chemical binding]; other site 426117005723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117005724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005725 active site 426117005726 phosphorylation site [posttranslational modification] 426117005727 intermolecular recognition site; other site 426117005728 dimerization interface [polypeptide binding]; other site 426117005729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117005730 DNA binding residues [nucleotide binding] 426117005731 amidase; Provisional; Region: PRK09201 426117005732 Amidase; Region: Amidase; pfam01425 426117005733 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 426117005734 GLTT repeat (6 copies); Region: GLTT; pfam01744 426117005735 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 426117005736 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 426117005737 active site 426117005738 putative substrate binding pocket [chemical binding]; other site 426117005739 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 426117005740 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 426117005741 Walker A/P-loop; other site 426117005742 ATP binding site [chemical binding]; other site 426117005743 Q-loop/lid; other site 426117005744 ABC transporter signature motif; other site 426117005745 Walker B; other site 426117005746 D-loop; other site 426117005747 H-loop/switch region; other site 426117005748 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 426117005749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117005750 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 426117005751 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 426117005752 TM-ABC transporter signature motif; other site 426117005753 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 426117005754 TM-ABC transporter signature motif; other site 426117005755 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 426117005756 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 426117005757 putative ligand binding site [chemical binding]; other site 426117005758 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 426117005759 nudix motif; other site 426117005760 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117005761 MarR family; Region: MarR; pfam01047 426117005762 selenocysteine synthase; Provisional; Region: PRK04311 426117005763 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 426117005764 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 426117005765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117005766 catalytic residue [active] 426117005767 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 426117005768 NlpC/P60 family; Region: NLPC_P60; pfam00877 426117005769 AzlC protein; Region: AzlC; cl00570 426117005770 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 426117005771 C factor cell-cell signaling protein; Provisional; Region: PRK09009 426117005772 NADP binding site [chemical binding]; other site 426117005773 homodimer interface [polypeptide binding]; other site 426117005774 active site 426117005775 Predicted ATPase [General function prediction only]; Region: COG1485 426117005776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117005777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117005778 malate dehydrogenase; Reviewed; Region: PRK06223 426117005779 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 426117005780 NAD(P) binding site [chemical binding]; other site 426117005781 dimer interface [polypeptide binding]; other site 426117005782 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426117005783 substrate binding site [chemical binding]; other site 426117005784 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 426117005785 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 426117005786 CoA-ligase; Region: Ligase_CoA; pfam00549 426117005787 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 426117005788 CoA binding domain; Region: CoA_binding; smart00881 426117005789 CoA-ligase; Region: Ligase_CoA; pfam00549 426117005790 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 426117005791 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 426117005792 TPP-binding site [chemical binding]; other site 426117005793 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 426117005794 PYR/PP interface [polypeptide binding]; other site 426117005795 dimer interface [polypeptide binding]; other site 426117005796 TPP binding site [chemical binding]; other site 426117005797 YCII-related domain; Region: YCII; cl00999 426117005798 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 426117005799 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117005800 E3 interaction surface; other site 426117005801 lipoyl attachment site [posttranslational modification]; other site 426117005802 e3 binding domain; Region: E3_binding; pfam02817 426117005803 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426117005804 short chain dehydrogenase; Provisional; Region: PRK06123 426117005805 classical (c) SDRs; Region: SDR_c; cd05233 426117005806 NAD(P) binding site [chemical binding]; other site 426117005807 active site 426117005808 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 426117005809 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 426117005810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117005811 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426117005812 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 426117005813 active site 426117005814 dimer interface [polypeptide binding]; other site 426117005815 metal binding site [ion binding]; metal-binding site 426117005816 shikimate kinase; Provisional; Region: PRK13946 426117005817 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 426117005818 ADP binding site [chemical binding]; other site 426117005819 magnesium binding site [ion binding]; other site 426117005820 putative shikimate binding site; other site 426117005821 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 426117005822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117005823 active site 426117005824 DNA binding site [nucleotide binding] 426117005825 Int/Topo IB signature motif; other site 426117005826 EVE domain; Region: EVE; pfam01878 426117005827 PRC-barrel domain; Region: PRC; pfam05239 426117005828 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 426117005829 methionine sulfoxide reductase A; Provisional; Region: PRK00058 426117005830 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 426117005831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117005832 motif II; other site 426117005833 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117005834 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426117005835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005836 dimer interface [polypeptide binding]; other site 426117005837 phosphorylation site [posttranslational modification] 426117005838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005839 ATP binding site [chemical binding]; other site 426117005840 G-X-G motif; other site 426117005841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005842 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005843 active site 426117005844 phosphorylation site [posttranslational modification] 426117005845 intermolecular recognition site; other site 426117005846 dimerization interface [polypeptide binding]; other site 426117005847 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 426117005848 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 426117005849 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 426117005850 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 426117005851 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 426117005852 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 426117005853 Walker A/P-loop; other site 426117005854 ATP binding site [chemical binding]; other site 426117005855 Q-loop/lid; other site 426117005856 ABC transporter signature motif; other site 426117005857 Walker B; other site 426117005858 D-loop; other site 426117005859 H-loop/switch region; other site 426117005860 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 426117005861 dimer interface [polypeptide binding]; other site 426117005862 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 426117005863 PII uridylyl-transferase; Provisional; Region: PRK05092 426117005864 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426117005865 metal binding triad; other site 426117005866 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 426117005867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117005868 Zn2+ binding site [ion binding]; other site 426117005869 Mg2+ binding site [ion binding]; other site 426117005870 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 426117005871 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 426117005872 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117005873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117005874 substrate binding pocket [chemical binding]; other site 426117005875 membrane-bound complex binding site; other site 426117005876 hinge residues; other site 426117005877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426117005878 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117005879 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117005880 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117005881 Walker A/P-loop; other site 426117005882 ATP binding site [chemical binding]; other site 426117005883 Q-loop/lid; other site 426117005884 ABC transporter signature motif; other site 426117005885 Walker B; other site 426117005886 D-loop; other site 426117005887 H-loop/switch region; other site 426117005888 OsmC-like protein; Region: OsmC; pfam02566 426117005889 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 426117005890 30S subunit binding site; other site 426117005891 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426117005892 active site 426117005893 phosphorylation site [posttranslational modification] 426117005894 Uncharacterized conserved protein [Function unknown]; Region: COG1434 426117005895 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 426117005896 putative active site [active] 426117005897 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 426117005898 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 426117005899 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117005900 Walker A/P-loop; other site 426117005901 ATP binding site [chemical binding]; other site 426117005902 Q-loop/lid; other site 426117005903 ABC transporter signature motif; other site 426117005904 Walker B; other site 426117005905 D-loop; other site 426117005906 H-loop/switch region; other site 426117005907 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 426117005908 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 426117005909 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 426117005910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117005911 active site 426117005912 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005914 active site 426117005915 phosphorylation site [posttranslational modification] 426117005916 intermolecular recognition site; other site 426117005917 dimerization interface [polypeptide binding]; other site 426117005918 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 426117005919 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 426117005920 active site 426117005921 acyl-activating enzyme (AAE) consensus motif; other site 426117005922 putative CoA binding site [chemical binding]; other site 426117005923 AMP binding site [chemical binding]; other site 426117005924 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 426117005925 putative FMN binding site [chemical binding]; other site 426117005926 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 426117005927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117005928 putative DNA binding site [nucleotide binding]; other site 426117005929 putative Zn2+ binding site [ion binding]; other site 426117005930 AsnC family; Region: AsnC_trans_reg; pfam01037 426117005931 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 426117005932 Proline dehydrogenase; Region: Pro_dh; pfam01619 426117005933 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 426117005934 Glutamate binding site [chemical binding]; other site 426117005935 NAD binding site [chemical binding]; other site 426117005936 catalytic residues [active] 426117005937 PAS fold; Region: PAS_7; pfam12860 426117005938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117005939 PAS fold; Region: PAS_3; pfam08447 426117005940 putative active site [active] 426117005941 heme pocket [chemical binding]; other site 426117005942 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117005943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117005944 metal binding site [ion binding]; metal-binding site 426117005945 active site 426117005946 I-site; other site 426117005947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005948 active site 426117005949 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117005950 phosphorylation site [posttranslational modification] 426117005951 intermolecular recognition site; other site 426117005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005953 ATP binding site [chemical binding]; other site 426117005954 Mg2+ binding site [ion binding]; other site 426117005955 G-X-G motif; other site 426117005956 Response regulator receiver domain; Region: Response_reg; pfam00072 426117005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005958 active site 426117005959 phosphorylation site [posttranslational modification] 426117005960 intermolecular recognition site; other site 426117005961 dimerization interface [polypeptide binding]; other site 426117005962 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117005963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117005964 active site 426117005965 phosphorylation site [posttranslational modification] 426117005966 intermolecular recognition site; other site 426117005967 dimerization interface [polypeptide binding]; other site 426117005968 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 426117005969 GAF domain; Region: GAF; pfam01590 426117005970 Phytochrome region; Region: PHY; pfam00360 426117005971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117005972 dimer interface [polypeptide binding]; other site 426117005973 phosphorylation site [posttranslational modification] 426117005974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117005975 ATP binding site [chemical binding]; other site 426117005976 Mg2+ binding site [ion binding]; other site 426117005977 G-X-G motif; other site 426117005978 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117005979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117005980 Walker A/P-loop; other site 426117005981 ATP binding site [chemical binding]; other site 426117005982 Q-loop/lid; other site 426117005983 ABC transporter signature motif; other site 426117005984 Walker B; other site 426117005985 D-loop; other site 426117005986 H-loop/switch region; other site 426117005987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117005988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117005989 Walker A/P-loop; other site 426117005990 ATP binding site [chemical binding]; other site 426117005991 Q-loop/lid; other site 426117005992 ABC transporter signature motif; other site 426117005993 Walker B; other site 426117005994 D-loop; other site 426117005995 H-loop/switch region; other site 426117005996 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117005997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117005998 dimer interface [polypeptide binding]; other site 426117005999 conserved gate region; other site 426117006000 putative PBP binding loops; other site 426117006001 ABC-ATPase subunit interface; other site 426117006002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117006003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117006004 dimer interface [polypeptide binding]; other site 426117006005 conserved gate region; other site 426117006006 putative PBP binding loops; other site 426117006007 ABC-ATPase subunit interface; other site 426117006008 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426117006009 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117006010 urease subunit alpha; Reviewed; Region: ureC; PRK13207 426117006011 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 426117006012 subunit interactions [polypeptide binding]; other site 426117006013 active site 426117006014 flap region; other site 426117006015 RNA ligase; Region: RNA_lig_T4_1; pfam09511 426117006016 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 426117006017 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 426117006018 alpha-gamma subunit interface [polypeptide binding]; other site 426117006019 beta-gamma subunit interface [polypeptide binding]; other site 426117006020 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 426117006021 alpha-beta subunit interface [polypeptide binding]; other site 426117006022 UreD urease accessory protein; Region: UreD; pfam01774 426117006023 Cupin domain; Region: Cupin_2; cl17218 426117006024 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426117006025 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426117006026 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426117006027 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426117006028 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426117006029 lipoprotein signal peptidase; Provisional; Region: PRK14796 426117006030 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 426117006031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117006032 active site 426117006033 HIGH motif; other site 426117006034 nucleotide binding site [chemical binding]; other site 426117006035 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 426117006036 active site 426117006037 KMSKS motif; other site 426117006038 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 426117006039 tRNA binding surface [nucleotide binding]; other site 426117006040 anticodon binding site; other site 426117006041 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 426117006042 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 426117006043 active site 426117006044 Riboflavin kinase; Region: Flavokinase; smart00904 426117006045 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 426117006046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117006047 active site 426117006048 phosphorylation site [posttranslational modification] 426117006049 intermolecular recognition site; other site 426117006050 dimerization interface [polypeptide binding]; other site 426117006051 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 426117006052 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 426117006053 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 426117006054 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 426117006055 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 426117006056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117006057 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 426117006058 active site 426117006059 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 426117006060 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 426117006061 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426117006062 NAD binding site [chemical binding]; other site 426117006063 homotetramer interface [polypeptide binding]; other site 426117006064 homodimer interface [polypeptide binding]; other site 426117006065 substrate binding site [chemical binding]; other site 426117006066 active site 426117006067 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 426117006068 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426117006069 dimer interface [polypeptide binding]; other site 426117006070 active site 426117006071 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 426117006072 active site 1 [active] 426117006073 dimer interface [polypeptide binding]; other site 426117006074 active site 2 [active] 426117006075 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426117006076 metal binding site 2 [ion binding]; metal-binding site 426117006077 putative DNA binding helix; other site 426117006078 metal binding site 1 [ion binding]; metal-binding site 426117006079 dimer interface [polypeptide binding]; other site 426117006080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 426117006081 Bacterial SH3 domain; Region: SH3_4; pfam06347 426117006082 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426117006083 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 426117006084 dimerization interface [polypeptide binding]; other site 426117006085 ligand binding site [chemical binding]; other site 426117006086 NADP binding site [chemical binding]; other site 426117006087 catalytic site [active] 426117006088 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426117006089 hypothetical protein; Provisional; Region: PRK07208 426117006090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117006091 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 426117006092 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 426117006093 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 426117006094 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 426117006095 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 426117006096 putative NAD(P) binding site [chemical binding]; other site 426117006097 active site 426117006098 CysZ-like protein; Reviewed; Region: PRK12768 426117006099 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 426117006100 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 426117006101 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 426117006102 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 426117006103 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 426117006104 UbiA prenyltransferase family; Region: UbiA; pfam01040 426117006105 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426117006106 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 426117006107 active site 426117006108 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 426117006109 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 426117006110 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117006111 RNA binding surface [nucleotide binding]; other site 426117006112 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426117006113 glutamate racemase; Provisional; Region: PRK00865 426117006114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117006115 dimer interface [polypeptide binding]; other site 426117006116 putative CheW interface [polypeptide binding]; other site 426117006117 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 426117006118 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 426117006119 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 426117006120 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 426117006121 von Willebrand factor type A domain; Region: VWA_2; pfam13519 426117006122 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426117006123 HSP70 interaction site [polypeptide binding]; other site 426117006124 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426117006125 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426117006126 Sporulation related domain; Region: SPOR; pfam05036 426117006127 Phasin protein; Region: Phasin_2; pfam09361 426117006128 Uncharacterized conserved protein [Function unknown]; Region: COG2127 426117006129 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 426117006130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117006131 Walker A motif; other site 426117006132 ATP binding site [chemical binding]; other site 426117006133 Walker B motif; other site 426117006134 arginine finger; other site 426117006135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117006136 Walker A motif; other site 426117006137 ATP binding site [chemical binding]; other site 426117006138 Walker B motif; other site 426117006139 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426117006140 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117006141 DNA-binding site [nucleotide binding]; DNA binding site 426117006142 RNA-binding motif; other site 426117006143 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117006144 DNA-binding site [nucleotide binding]; DNA binding site 426117006145 RNA-binding motif; other site 426117006146 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 426117006147 putative FMN binding site [chemical binding]; other site 426117006148 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 426117006149 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 426117006150 G1 box; other site 426117006151 putative GEF interaction site [polypeptide binding]; other site 426117006152 GTP/Mg2+ binding site [chemical binding]; other site 426117006153 Switch I region; other site 426117006154 G2 box; other site 426117006155 G3 box; other site 426117006156 Switch II region; other site 426117006157 G4 box; other site 426117006158 G5 box; other site 426117006159 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 426117006160 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 426117006161 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 426117006162 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117006163 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117006164 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117006165 Walker A/P-loop; other site 426117006166 ATP binding site [chemical binding]; other site 426117006167 Q-loop/lid; other site 426117006168 ABC transporter signature motif; other site 426117006169 Walker B; other site 426117006170 D-loop; other site 426117006171 H-loop/switch region; other site 426117006172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117006173 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117006174 Walker A/P-loop; other site 426117006175 ATP binding site [chemical binding]; other site 426117006176 Q-loop/lid; other site 426117006177 ABC transporter signature motif; other site 426117006178 Walker B; other site 426117006179 D-loop; other site 426117006180 H-loop/switch region; other site 426117006181 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117006182 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117006183 TM-ABC transporter signature motif; other site 426117006184 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117006185 TM-ABC transporter signature motif; other site 426117006186 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117006187 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117006188 META domain; Region: META; pfam03724 426117006189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117006190 non-specific DNA binding site [nucleotide binding]; other site 426117006191 salt bridge; other site 426117006192 sequence-specific DNA binding site [nucleotide binding]; other site 426117006193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117006194 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 426117006195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117006196 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117006197 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117006198 Walker A/P-loop; other site 426117006199 ATP binding site [chemical binding]; other site 426117006200 Q-loop/lid; other site 426117006201 ABC transporter signature motif; other site 426117006202 Walker B; other site 426117006203 D-loop; other site 426117006204 H-loop/switch region; other site 426117006205 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117006206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117006207 dimer interface [polypeptide binding]; other site 426117006208 conserved gate region; other site 426117006209 putative PBP binding loops; other site 426117006210 ABC-ATPase subunit interface; other site 426117006211 NMT1-like family; Region: NMT1_2; pfam13379 426117006212 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117006213 substrate binding pocket [chemical binding]; other site 426117006214 membrane-bound complex binding site; other site 426117006215 GAF domain; Region: GAF_2; pfam13185 426117006216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117006217 Histidine kinase; Region: HisKA_2; pfam07568 426117006218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117006219 ATP binding site [chemical binding]; other site 426117006220 Mg2+ binding site [ion binding]; other site 426117006221 G-X-G motif; other site 426117006222 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 426117006223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117006224 motif II; other site 426117006225 phosphoribulokinase; Provisional; Region: PRK15453 426117006226 active site 426117006227 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 426117006228 active site 426117006229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117006230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006231 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 426117006232 putative dimerization interface [polypeptide binding]; other site 426117006233 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 426117006234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117006235 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117006236 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 426117006237 YcaO-like family; Region: YcaO; pfam02624 426117006238 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426117006239 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426117006240 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 426117006241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117006242 S-adenosylmethionine binding site [chemical binding]; other site 426117006243 HD domain; Region: HD_3; cl17350 426117006244 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 426117006245 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117006246 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117006247 catalytic residue [active] 426117006248 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 426117006249 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117006250 catalytic loop [active] 426117006251 iron binding site [ion binding]; other site 426117006252 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117006253 cyclase homology domain; Region: CHD; cd07302 426117006254 nucleotidyl binding site; other site 426117006255 metal binding site [ion binding]; metal-binding site 426117006256 dimer interface [polypeptide binding]; other site 426117006257 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426117006258 Cation efflux family; Region: Cation_efflux; pfam01545 426117006259 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 426117006260 fructokinase; Reviewed; Region: PRK09557 426117006261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 426117006262 nucleotide binding site [chemical binding]; other site 426117006263 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426117006264 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117006265 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 426117006266 putative active site; other site 426117006267 putative triphosphate binding site [ion binding]; other site 426117006268 putative metal binding residues [ion binding]; other site 426117006269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117006270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117006272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117006273 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426117006274 active site 426117006275 homotetramer interface [polypeptide binding]; other site 426117006276 homodimer interface [polypeptide binding]; other site 426117006277 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117006278 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117006279 Walker A/P-loop; other site 426117006280 ATP binding site [chemical binding]; other site 426117006281 Q-loop/lid; other site 426117006282 ABC transporter signature motif; other site 426117006283 Walker B; other site 426117006284 D-loop; other site 426117006285 H-loop/switch region; other site 426117006286 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117006287 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 426117006288 putative ligand binding site [chemical binding]; other site 426117006289 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117006290 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117006291 TM-ABC transporter signature motif; other site 426117006292 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117006293 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117006294 TM-ABC transporter signature motif; other site 426117006295 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 426117006296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117006297 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 426117006298 acyl-activating enzyme (AAE) consensus motif; other site 426117006299 putative AMP binding site [chemical binding]; other site 426117006300 putative active site [active] 426117006301 putative CoA binding site [chemical binding]; other site 426117006302 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117006303 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117006304 Walker A/P-loop; other site 426117006305 ATP binding site [chemical binding]; other site 426117006306 Q-loop/lid; other site 426117006307 ABC transporter signature motif; other site 426117006308 Walker B; other site 426117006309 D-loop; other site 426117006310 H-loop/switch region; other site 426117006311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117006312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117006313 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 426117006314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117006315 acyl-activating enzyme (AAE) consensus motif; other site 426117006316 active site 426117006317 AMP binding site [chemical binding]; other site 426117006318 CoA binding site [chemical binding]; other site 426117006319 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 426117006320 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426117006321 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 426117006322 putative active site [active] 426117006323 putative catalytic site [active] 426117006324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426117006325 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 426117006326 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117006327 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426117006328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426117006329 carboxyltransferase (CT) interaction site; other site 426117006330 biotinylation site [posttranslational modification]; other site 426117006331 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 426117006332 isovaleryl-CoA dehydrogenase; Region: PLN02519 426117006333 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 426117006334 substrate binding site [chemical binding]; other site 426117006335 FAD binding site [chemical binding]; other site 426117006336 catalytic base [active] 426117006337 AMP-binding domain protein; Validated; Region: PRK08315 426117006338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117006339 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 426117006340 acyl-activating enzyme (AAE) consensus motif; other site 426117006341 putative AMP binding site [chemical binding]; other site 426117006342 putative active site [active] 426117006343 putative CoA binding site [chemical binding]; other site 426117006344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117006345 dimerization interface [polypeptide binding]; other site 426117006346 putative DNA binding site [nucleotide binding]; other site 426117006347 putative Zn2+ binding site [ion binding]; other site 426117006348 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 426117006349 putative hydrophobic ligand binding site [chemical binding]; other site 426117006350 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 426117006351 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 426117006352 oligomer interface [polypeptide binding]; other site 426117006353 active site residues [active] 426117006354 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426117006355 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426117006356 dimer interface [polypeptide binding]; other site 426117006357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117006358 catalytic residue [active] 426117006359 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 426117006360 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 426117006361 dimer interface [polypeptide binding]; other site 426117006362 PYR/PP interface [polypeptide binding]; other site 426117006363 TPP binding site [chemical binding]; other site 426117006364 substrate binding site [chemical binding]; other site 426117006365 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 426117006366 TPP-binding site; other site 426117006367 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 426117006368 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 426117006369 active site 426117006370 putative DNA-binding cleft [nucleotide binding]; other site 426117006371 dimer interface [polypeptide binding]; other site 426117006372 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 426117006373 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426117006374 C-terminal domain interface [polypeptide binding]; other site 426117006375 GSH binding site (G-site) [chemical binding]; other site 426117006376 dimer interface [polypeptide binding]; other site 426117006377 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426117006378 N-terminal domain interface [polypeptide binding]; other site 426117006379 dimer interface [polypeptide binding]; other site 426117006380 substrate binding pocket (H-site) [chemical binding]; other site 426117006381 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 426117006382 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426117006383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006384 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426117006385 dimerization interface [polypeptide binding]; other site 426117006386 substrate binding pocket [chemical binding]; other site 426117006387 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 426117006388 High-affinity nickel-transport protein; Region: NicO; cl00964 426117006389 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 426117006390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117006391 Walker A/P-loop; other site 426117006392 ATP binding site [chemical binding]; other site 426117006393 Q-loop/lid; other site 426117006394 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 426117006395 FAD binding pocket [chemical binding]; other site 426117006396 FAD binding motif [chemical binding]; other site 426117006397 phosphate binding motif [ion binding]; other site 426117006398 beta-alpha-beta structure motif; other site 426117006399 NAD binding pocket [chemical binding]; other site 426117006400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117006401 active site 426117006402 phosphorylation site [posttranslational modification] 426117006403 intermolecular recognition site; other site 426117006404 dimerization interface [polypeptide binding]; other site 426117006405 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 426117006406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117006407 PAS fold; Region: PAS_3; pfam08447 426117006408 putative active site [active] 426117006409 heme pocket [chemical binding]; other site 426117006410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117006411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117006412 metal binding site [ion binding]; metal-binding site 426117006413 active site 426117006414 I-site; other site 426117006415 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117006416 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426117006417 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426117006418 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426117006419 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 426117006420 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 426117006421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117006422 catalytic residue [active] 426117006423 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 426117006424 Protein of unknown function (DUF983); Region: DUF983; cl02211 426117006425 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 426117006426 Subunit III/VIIa interface [polypeptide binding]; other site 426117006427 Phospholipid binding site [chemical binding]; other site 426117006428 Subunit I/III interface [polypeptide binding]; other site 426117006429 Subunit III/VIb interface [polypeptide binding]; other site 426117006430 Subunit III/VIa interface; other site 426117006431 Subunit III/Vb interface [polypeptide binding]; other site 426117006432 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 426117006433 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 426117006434 UbiA prenyltransferase family; Region: UbiA; pfam01040 426117006435 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426117006436 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 426117006437 Subunit I/III interface [polypeptide binding]; other site 426117006438 D-pathway; other site 426117006439 Subunit I/VIIc interface [polypeptide binding]; other site 426117006440 Subunit I/IV interface [polypeptide binding]; other site 426117006441 Subunit I/II interface [polypeptide binding]; other site 426117006442 Low-spin heme (heme a) binding site [chemical binding]; other site 426117006443 Subunit I/VIIa interface [polypeptide binding]; other site 426117006444 Dimer interface; other site 426117006445 Subunit I/VIa interface [polypeptide binding]; other site 426117006446 Putative water exit pathway; other site 426117006447 Binuclear center (heme a3/CuB) [ion binding]; other site 426117006448 K-pathway; other site 426117006449 Subunit I/Vb interface [polypeptide binding]; other site 426117006450 Putative proton exit pathway; other site 426117006451 Subunit I/VIb interface; other site 426117006452 Subunit I/VIc interface [polypeptide binding]; other site 426117006453 Electron transfer pathway; other site 426117006454 Subunit I/VIIIb interface [polypeptide binding]; other site 426117006455 Subunit I/VIIb interface [polypeptide binding]; other site 426117006456 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 426117006457 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117006458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117006459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117006461 dimerization interface [polypeptide binding]; other site 426117006462 Uncharacterized conserved protein [Function unknown]; Region: COG3791 426117006463 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 426117006464 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 426117006465 putative dimer interface [polypeptide binding]; other site 426117006466 [2Fe-2S] cluster binding site [ion binding]; other site 426117006467 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 426117006468 putative dimer interface [polypeptide binding]; other site 426117006469 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 426117006470 SLBB domain; Region: SLBB; pfam10531 426117006471 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 426117006472 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 426117006473 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 426117006474 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 426117006475 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426117006476 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 426117006477 RibD C-terminal domain; Region: RibD_C; pfam01872 426117006478 GTP cyclohydrolase; Provisional; Region: PRK08815 426117006479 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 426117006480 dimerization interface [polypeptide binding]; other site 426117006481 active site 426117006482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117006483 S-adenosylmethionine binding site [chemical binding]; other site 426117006484 Helix-turn-helix domain; Region: HTH_31; pfam13560 426117006485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117006486 dimerization interface [polypeptide binding]; other site 426117006487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117006488 dimer interface [polypeptide binding]; other site 426117006489 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426117006490 putative CheW interface [polypeptide binding]; other site 426117006491 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 426117006492 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 426117006493 NADP binding site [chemical binding]; other site 426117006494 dimer interface [polypeptide binding]; other site 426117006495 transcription elongation factor regulatory protein; Validated; Region: PRK06342 426117006496 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 426117006497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117006498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117006500 dimerization interface [polypeptide binding]; other site 426117006501 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 426117006502 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117006503 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 426117006504 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 426117006505 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117006506 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117006507 active site 426117006508 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 426117006509 enoyl-CoA hydratase; Provisional; Region: PRK06688 426117006510 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117006511 substrate binding site [chemical binding]; other site 426117006512 oxyanion hole (OAH) forming residues; other site 426117006513 trimer interface [polypeptide binding]; other site 426117006514 short chain dehydrogenase; Provisional; Region: PRK08303 426117006515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117006516 NAD(P) binding site [chemical binding]; other site 426117006517 active site 426117006518 short chain dehydrogenase; Provisional; Region: PRK08278 426117006519 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 426117006520 NAD(P) binding site [chemical binding]; other site 426117006521 homodimer interface [polypeptide binding]; other site 426117006522 active site 426117006523 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426117006524 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 426117006525 Cl binding site [ion binding]; other site 426117006526 oligomer interface [polypeptide binding]; other site 426117006527 Uncharacterized conserved protein [Function unknown]; Region: COG2135 426117006528 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 426117006529 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 426117006530 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 426117006531 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 426117006532 E-class dimer interface [polypeptide binding]; other site 426117006533 P-class dimer interface [polypeptide binding]; other site 426117006534 active site 426117006535 Cu2+ binding site [ion binding]; other site 426117006536 Zn2+ binding site [ion binding]; other site 426117006537 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 426117006538 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 426117006539 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426117006540 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 426117006541 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 426117006542 ATP binding site [chemical binding]; other site 426117006543 Walker A motif; other site 426117006544 hexamer interface [polypeptide binding]; other site 426117006545 Walker B motif; other site 426117006546 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 426117006547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117006548 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 426117006549 Type IV pili component [Cell motility and secretion]; Region: COG5461 426117006550 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 426117006551 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 426117006552 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 426117006553 BON domain; Region: BON; pfam04972 426117006554 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 426117006555 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 426117006556 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426117006557 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 426117006558 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 426117006559 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 426117006560 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117006561 TadE-like protein; Region: TadE; pfam07811 426117006562 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117006563 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 426117006564 catalytic motif [active] 426117006565 Catalytic residue [active] 426117006566 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 426117006567 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 426117006568 5S rRNA interface [nucleotide binding]; other site 426117006569 CTC domain interface [polypeptide binding]; other site 426117006570 L16 interface [polypeptide binding]; other site 426117006571 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 426117006572 putative active site [active] 426117006573 catalytic residue [active] 426117006574 GTP-binding protein YchF; Reviewed; Region: PRK09601 426117006575 YchF GTPase; Region: YchF; cd01900 426117006576 G1 box; other site 426117006577 GTP/Mg2+ binding site [chemical binding]; other site 426117006578 Switch I region; other site 426117006579 G2 box; other site 426117006580 Switch II region; other site 426117006581 G3 box; other site 426117006582 G4 box; other site 426117006583 G5 box; other site 426117006584 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 426117006585 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 426117006586 Active_site [active] 426117006587 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 426117006588 putative active site [active] 426117006589 putative catalytic site [active] 426117006590 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 426117006591 putative active site [active] 426117006592 putative catalytic site [active] 426117006593 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117006594 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117006595 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117006596 catalytic residue [active] 426117006597 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 426117006598 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426117006599 dimer interface [polypeptide binding]; other site 426117006600 active site 426117006601 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 426117006602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117006603 non-specific DNA binding site [nucleotide binding]; other site 426117006604 salt bridge; other site 426117006605 sequence-specific DNA binding site [nucleotide binding]; other site 426117006606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117006607 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 426117006608 Walker A/P-loop; other site 426117006609 ADP binding site [chemical binding]; other site 426117006610 ATP binding site [chemical binding]; other site 426117006611 magnesium binding site [ion binding]; other site 426117006612 putative shikimate binding site; other site 426117006613 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117006614 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117006615 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 426117006616 serine acetyltransferase; Provisional; Region: cysE; PRK11132 426117006617 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 426117006618 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 426117006619 trimer interface [polypeptide binding]; other site 426117006620 active site 426117006621 substrate binding site [chemical binding]; other site 426117006622 CoA binding site [chemical binding]; other site 426117006623 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426117006624 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426117006625 Isochorismatase family; Region: Isochorismatase; pfam00857 426117006626 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426117006627 catalytic triad [active] 426117006628 conserved cis-peptide bond; other site 426117006629 PilZ domain; Region: PilZ; pfam07238 426117006630 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 426117006631 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 426117006632 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614 426117006633 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 426117006634 major curlin subunit; Provisional; Region: csgA; PRK10051 426117006635 major curlin subunit; Provisional; Region: csgA; PRK10051 426117006636 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 426117006637 DNA binding residues [nucleotide binding] 426117006638 dimerization interface [polypeptide binding]; other site 426117006639 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 426117006640 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 426117006641 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117006642 Cupin domain; Region: Cupin_2; pfam07883 426117006643 Helix-turn-helix domain; Region: HTH_18; pfam12833 426117006644 EamA-like transporter family; Region: EamA; pfam00892 426117006645 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 426117006646 dimer interface [polypeptide binding]; other site 426117006647 active site 426117006648 Schiff base residues; other site 426117006649 cobyric acid synthase; Provisional; Region: PRK00784 426117006650 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117006651 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 426117006652 catalytic triad [active] 426117006653 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 426117006654 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 426117006655 homodimer interface [polypeptide binding]; other site 426117006656 Walker A motif; other site 426117006657 ATP binding site [chemical binding]; other site 426117006658 hydroxycobalamin binding site [chemical binding]; other site 426117006659 Walker B motif; other site 426117006660 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 426117006661 homotrimer interface [polypeptide binding]; other site 426117006662 Walker A motif; other site 426117006663 GTP binding site [chemical binding]; other site 426117006664 Walker B motif; other site 426117006665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117006666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117006668 dimerization interface [polypeptide binding]; other site 426117006669 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117006670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117006671 putative substrate translocation pore; other site 426117006672 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 426117006673 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 426117006674 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 426117006675 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 426117006676 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426117006677 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426117006678 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 426117006679 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 426117006680 precorrin-3B synthase; Region: CobG; TIGR02435 426117006681 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426117006682 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 426117006683 Precorrin-8X methylmutase; Region: CbiC; pfam02570 426117006684 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 426117006685 active site 426117006686 SAM binding site [chemical binding]; other site 426117006687 homodimer interface [polypeptide binding]; other site 426117006688 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 426117006689 active site 426117006690 SAM binding site [chemical binding]; other site 426117006691 homodimer interface [polypeptide binding]; other site 426117006692 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 426117006693 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 426117006694 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 426117006695 active site 426117006696 putative homodimer interface [polypeptide binding]; other site 426117006697 SAM binding site [chemical binding]; other site 426117006698 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 426117006699 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 426117006700 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 426117006701 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 426117006702 active site 426117006703 SAM binding site [chemical binding]; other site 426117006704 homodimer interface [polypeptide binding]; other site 426117006705 RHS protein; Region: RHS; pfam03527 426117006706 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 426117006707 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117006708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117006709 Walker A motif; other site 426117006710 ATP binding site [chemical binding]; other site 426117006711 Walker B motif; other site 426117006712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117006713 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117006714 Integrase core domain; Region: rve; pfam00665 426117006715 RHS Repeat; Region: RHS_repeat; cl11982 426117006716 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 426117006717 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 426117006718 RHS Repeat; Region: RHS_repeat; cl11982 426117006719 RHS Repeat; Region: RHS_repeat; pfam05593 426117006720 RHS Repeat; Region: RHS_repeat; pfam05593 426117006721 RHS Repeat; Region: RHS_repeat; pfam05593 426117006722 RHS Repeat; Region: RHS_repeat; cl11982 426117006723 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 426117006724 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 426117006725 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 426117006726 conserved cys residue [active] 426117006727 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117006728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117006729 non-specific DNA binding site [nucleotide binding]; other site 426117006730 salt bridge; other site 426117006731 sequence-specific DNA binding site [nucleotide binding]; other site 426117006732 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 426117006733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117006734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117006735 putative substrate translocation pore; other site 426117006736 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 426117006737 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426117006738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117006739 putative substrate translocation pore; other site 426117006740 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 426117006741 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 426117006742 dimer interface [polypeptide binding]; other site 426117006743 anticodon binding site; other site 426117006744 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117006745 motif 1; other site 426117006746 dimer interface [polypeptide binding]; other site 426117006747 active site 426117006748 motif 2; other site 426117006749 GAD domain; Region: GAD; pfam02938 426117006750 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117006751 active site 426117006752 motif 3; other site 426117006753 putative acetyltransferase; Provisional; Region: PRK03624 426117006754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117006755 Coenzyme A binding pocket [chemical binding]; other site 426117006756 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 426117006757 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 426117006758 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 426117006759 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 426117006760 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426117006761 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426117006762 putative NAD(P) binding site [chemical binding]; other site 426117006763 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 426117006764 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 426117006765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117006766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117006767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117006768 dimerization interface [polypeptide binding]; other site 426117006769 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 426117006770 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 426117006771 tetrameric interface [polypeptide binding]; other site 426117006772 NAD binding site [chemical binding]; other site 426117006773 catalytic residues [active] 426117006774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117006775 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 426117006776 substrate binding pocket [chemical binding]; other site 426117006777 FAD binding site [chemical binding]; other site 426117006778 catalytic base [active] 426117006779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117006780 sequence-specific DNA binding site [nucleotide binding]; other site 426117006781 salt bridge; other site 426117006782 Protein of unknown function (DUF497); Region: DUF497; pfam04365 426117006783 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117006784 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 426117006785 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 426117006786 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 426117006787 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 426117006788 active site 426117006789 HIGH motif; other site 426117006790 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117006791 KMSK motif region; other site 426117006792 tRNA binding surface [nucleotide binding]; other site 426117006793 DALR anticodon binding domain; Region: DALR_1; smart00836 426117006794 anticodon binding site; other site 426117006795 Sporulation related domain; Region: SPOR; pfam05036 426117006796 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 426117006797 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 426117006798 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 426117006799 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 426117006800 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 426117006801 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 426117006802 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 426117006803 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 426117006804 Protein of unknown function (DUF815); Region: DUF815; pfam05673 426117006805 Walker A motif; other site 426117006806 ATP binding site [chemical binding]; other site 426117006807 Walker B motif; other site 426117006808 PAS fold; Region: PAS_3; pfam08447 426117006809 PAS domain; Region: PAS_9; pfam13426 426117006810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117006811 non-specific DNA binding site [nucleotide binding]; other site 426117006812 salt bridge; other site 426117006813 sequence-specific DNA binding site [nucleotide binding]; other site 426117006814 Preprotein translocase subunit; Region: YajC; pfam02699 426117006815 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 426117006816 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 426117006817 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 426117006818 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 426117006819 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 426117006820 Protein export membrane protein; Region: SecD_SecF; pfam02355 426117006821 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 426117006822 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 426117006823 substrate binding pocket [chemical binding]; other site 426117006824 substrate-Mg2+ binding site; other site 426117006825 aspartate-rich region 1; other site 426117006826 aspartate-rich region 2; other site 426117006827 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 426117006828 Glucose inhibited division protein A; Region: GIDA; pfam01134 426117006829 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 426117006830 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426117006831 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117006832 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117006833 protein binding site [polypeptide binding]; other site 426117006834 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426117006835 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 426117006836 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426117006837 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426117006838 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 426117006839 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 426117006840 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 426117006841 tandem repeat interface [polypeptide binding]; other site 426117006842 oligomer interface [polypeptide binding]; other site 426117006843 active site residues [active] 426117006844 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426117006845 IHF dimer interface [polypeptide binding]; other site 426117006846 IHF - DNA interface [nucleotide binding]; other site 426117006847 ornithine cyclodeaminase; Validated; Region: PRK06141 426117006848 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 426117006849 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426117006850 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426117006851 putative dimer interface [polypeptide binding]; other site 426117006852 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 426117006853 active site 426117006854 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 426117006855 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 426117006856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117006857 catalytic residue [active] 426117006858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117006859 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117006860 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117006861 Transposase domain (DUF772); Region: DUF772; pfam05598 426117006862 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426117006863 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426117006864 Walker A/P-loop; other site 426117006865 ATP binding site [chemical binding]; other site 426117006866 Q-loop/lid; other site 426117006867 ABC transporter signature motif; other site 426117006868 Walker B; other site 426117006869 D-loop; other site 426117006870 H-loop/switch region; other site 426117006871 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117006872 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117006873 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117006874 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117006875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117006876 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117006877 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117006878 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117006879 Integrase core domain; Region: rve; pfam00665 426117006880 Winged helix-turn helix; Region: HTH_29; pfam13551 426117006881 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117006882 Homeodomain-like domain; Region: HTH_32; pfam13565 426117006883 Integrase core domain; Region: rve; pfam00665 426117006884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 426117006885 Integrase core domain; Region: rve_3; pfam13683 426117006886 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117006887 Ligand Binding Site [chemical binding]; other site 426117006888 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 426117006889 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117006890 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117006891 putative ligand binding site [chemical binding]; other site 426117006892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117006893 Cytochrome P450; Region: p450; cl12078 426117006894 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 426117006895 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 426117006896 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 426117006897 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117006898 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 426117006899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117006900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117006901 Transposase; Region: HTH_Tnp_1; pfam01527 426117006902 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 426117006903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117006904 Walker A/P-loop; other site 426117006905 ATP binding site [chemical binding]; other site 426117006906 Q-loop/lid; other site 426117006907 ABC transporter signature motif; other site 426117006908 Walker B; other site 426117006909 D-loop; other site 426117006910 H-loop/switch region; other site 426117006911 TOBE domain; Region: TOBE; cl01440 426117006912 dihydropyrimidinase; Provisional; Region: PRK13404 426117006913 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 426117006914 tetramer interface [polypeptide binding]; other site 426117006915 active site 426117006916 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426117006917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117006918 dimer interface [polypeptide binding]; other site 426117006919 putative CheW interface [polypeptide binding]; other site 426117006920 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426117006921 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 426117006922 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117006923 NAD(P) binding site [chemical binding]; other site 426117006924 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 426117006925 Predicted acetyltransferase [General function prediction only]; Region: COG2388 426117006926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117006927 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 426117006928 NAD(P) binding site [chemical binding]; other site 426117006929 active site 426117006930 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 426117006931 active site 426117006932 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426117006933 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 426117006934 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 426117006935 putative lipid kinase; Reviewed; Region: PRK13057 426117006936 allantoate amidohydrolase; Reviewed; Region: PRK12892 426117006937 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426117006938 active site 426117006939 metal binding site [ion binding]; metal-binding site 426117006940 dimer interface [polypeptide binding]; other site 426117006941 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426117006942 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426117006943 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 426117006944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426117006945 active site 426117006946 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117006947 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117006948 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117006949 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117006950 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117006951 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426117006952 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426117006953 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117006954 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426117006955 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117006956 PAS domain S-box; Region: sensory_box; TIGR00229 426117006957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117006958 putative active site [active] 426117006959 heme pocket [chemical binding]; other site 426117006960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117006961 HWE histidine kinase; Region: HWE_HK; pfam07536 426117006962 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426117006963 nucleophile elbow; other site 426117006964 Patatin phospholipase; Region: DUF3734; pfam12536 426117006965 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 426117006966 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 426117006967 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 426117006968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117006969 S-adenosylmethionine binding site [chemical binding]; other site 426117006970 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 426117006971 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 426117006972 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 426117006973 Zeta toxin; Region: Zeta_toxin; pfam06414 426117006974 formyl-coenzyme A transferase; Provisional; Region: PRK05398 426117006975 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117006976 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 426117006977 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 426117006978 active site 426117006979 substrate binding site [chemical binding]; other site 426117006980 cosubstrate binding site; other site 426117006981 catalytic site [active] 426117006982 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426117006983 substrate binding site [chemical binding]; other site 426117006984 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 426117006985 putative C-terminal domain interface [polypeptide binding]; other site 426117006986 putative GSH binding site (G-site) [chemical binding]; other site 426117006987 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117006988 putative dimer interface [polypeptide binding]; other site 426117006989 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426117006990 N-terminal domain interface [polypeptide binding]; other site 426117006991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117006992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117006993 dimer interface [polypeptide binding]; other site 426117006994 phosphorylation site [posttranslational modification] 426117006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117006996 ATP binding site [chemical binding]; other site 426117006997 Mg2+ binding site [ion binding]; other site 426117006998 G-X-G motif; other site 426117006999 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 426117007000 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117007001 catalytic loop [active] 426117007002 iron binding site [ion binding]; other site 426117007003 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117007004 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117007005 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117007006 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117007007 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117007008 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 426117007009 ligand binding site [chemical binding]; other site 426117007010 active site 426117007011 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 426117007012 nucleotide binding site [chemical binding]; other site 426117007013 putative NEF/HSP70 interaction site [polypeptide binding]; other site 426117007014 SBD interface [polypeptide binding]; other site 426117007015 ferrochelatase; Reviewed; Region: hemH; PRK00035 426117007016 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 426117007017 C-terminal domain interface [polypeptide binding]; other site 426117007018 active site 426117007019 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 426117007020 active site 426117007021 N-terminal domain interface [polypeptide binding]; other site 426117007022 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426117007023 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117007024 active site 426117007025 metal binding site [ion binding]; metal-binding site 426117007026 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426117007027 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 426117007028 ligand binding site [chemical binding]; other site 426117007029 active site 426117007030 UGI interface [polypeptide binding]; other site 426117007031 catalytic site [active] 426117007032 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 426117007033 amphipathic channel; other site 426117007034 Asn-Pro-Ala signature motifs; other site 426117007035 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 426117007036 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 426117007037 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 426117007038 putative active site [active] 426117007039 putative catalytic site [active] 426117007040 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 426117007041 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 426117007042 CoA binding domain; Region: CoA_binding_2; pfam13380 426117007043 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 426117007044 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 426117007045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426117007046 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117007047 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 426117007048 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 426117007049 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 426117007050 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 426117007051 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 426117007052 replicative DNA helicase; Provisional; Region: PRK09165 426117007053 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 426117007054 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 426117007055 Walker A motif; other site 426117007056 ATP binding site [chemical binding]; other site 426117007057 Walker B motif; other site 426117007058 DNA binding loops [nucleotide binding] 426117007059 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 426117007060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 426117007061 active site 426117007062 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426117007063 dimer interface [polypeptide binding]; other site 426117007064 substrate binding site [chemical binding]; other site 426117007065 catalytic residues [active] 426117007066 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426117007067 DNA repair protein RadA; Provisional; Region: PRK11823 426117007068 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 426117007069 Walker A motif/ATP binding site; other site 426117007070 ATP binding site [chemical binding]; other site 426117007071 Walker B motif; other site 426117007072 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 426117007073 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 426117007074 Colicin V production protein; Region: Colicin_V; pfam02674 426117007075 amidophosphoribosyltransferase; Provisional; Region: PRK09123 426117007076 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 426117007077 active site 426117007078 tetramer interface [polypeptide binding]; other site 426117007079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117007080 active site 426117007081 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 426117007082 classical (c) SDRs; Region: SDR_c; cd05233 426117007083 NAD(P) binding site [chemical binding]; other site 426117007084 active site 426117007085 HAMP domain; Region: HAMP; pfam00672 426117007086 dimerization interface [polypeptide binding]; other site 426117007087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 426117007088 folate binding site [chemical binding]; other site 426117007089 NADP+ binding site [chemical binding]; other site 426117007090 GTP-binding protein Der; Reviewed; Region: PRK00093 426117007091 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 426117007092 G1 box; other site 426117007093 GTP/Mg2+ binding site [chemical binding]; other site 426117007094 Switch I region; other site 426117007095 G2 box; other site 426117007096 Switch II region; other site 426117007097 G3 box; other site 426117007098 G4 box; other site 426117007099 G5 box; other site 426117007100 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 426117007101 G1 box; other site 426117007102 GTP/Mg2+ binding site [chemical binding]; other site 426117007103 Switch I region; other site 426117007104 G2 box; other site 426117007105 G3 box; other site 426117007106 Switch II region; other site 426117007107 G4 box; other site 426117007108 G5 box; other site 426117007109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 426117007110 NnrU protein; Region: NnrU; pfam07298 426117007111 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 426117007112 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426117007113 active site 426117007114 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 426117007115 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 426117007116 RNA binding site [nucleotide binding]; other site 426117007117 active site 426117007118 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 426117007119 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 426117007120 translation initiation factor IF-2; Region: IF-2; TIGR00487 426117007121 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 426117007122 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 426117007123 G1 box; other site 426117007124 putative GEF interaction site [polypeptide binding]; other site 426117007125 GTP/Mg2+ binding site [chemical binding]; other site 426117007126 Switch I region; other site 426117007127 G2 box; other site 426117007128 G3 box; other site 426117007129 Switch II region; other site 426117007130 G4 box; other site 426117007131 G5 box; other site 426117007132 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 426117007133 Translation-initiation factor 2; Region: IF-2; pfam11987 426117007134 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 426117007135 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 426117007136 putative RNA binding cleft [nucleotide binding]; other site 426117007137 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 426117007138 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 426117007139 NusA N-terminal domain; Region: NusA_N; pfam08529 426117007140 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 426117007141 RNA binding site [nucleotide binding]; other site 426117007142 homodimer interface [polypeptide binding]; other site 426117007143 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 426117007144 G-X-X-G motif; other site 426117007145 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 426117007146 G-X-X-G motif; other site 426117007147 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 426117007148 ribosome maturation protein RimP; Reviewed; Region: PRK00092 426117007149 Sm and related proteins; Region: Sm_like; cl00259 426117007150 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 426117007151 putative oligomer interface [polypeptide binding]; other site 426117007152 putative RNA binding site [nucleotide binding]; other site 426117007153 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 426117007154 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117007155 Walker A/P-loop; other site 426117007156 ATP binding site [chemical binding]; other site 426117007157 Q-loop/lid; other site 426117007158 ABC transporter signature motif; other site 426117007159 Walker B; other site 426117007160 D-loop; other site 426117007161 H-loop/switch region; other site 426117007162 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 426117007163 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117007164 Walker A/P-loop; other site 426117007165 ATP binding site [chemical binding]; other site 426117007166 Q-loop/lid; other site 426117007167 ABC transporter signature motif; other site 426117007168 Walker B; other site 426117007169 D-loop; other site 426117007170 H-loop/switch region; other site 426117007171 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117007172 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117007173 TM-ABC transporter signature motif; other site 426117007174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117007175 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117007176 TM-ABC transporter signature motif; other site 426117007177 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117007178 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 426117007179 putative ligand binding site [chemical binding]; other site 426117007180 trehalose synthase; Region: treS_nterm; TIGR02456 426117007181 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 426117007182 active site 426117007183 catalytic site [active] 426117007184 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 426117007185 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117007186 active site 426117007187 HIGH motif; other site 426117007188 nucleotide binding site [chemical binding]; other site 426117007189 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426117007190 active site 426117007191 KMSKS motif; other site 426117007192 guanine deaminase; Provisional; Region: PRK09228 426117007193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117007194 active site 426117007195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 426117007196 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 426117007197 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117007198 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117007199 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426117007200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426117007201 DNA binding site [nucleotide binding] 426117007202 domain linker motif; other site 426117007203 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 426117007204 putative dimerization interface [polypeptide binding]; other site 426117007205 putative ligand binding site [chemical binding]; other site 426117007206 putative aldolase; Validated; Region: PRK08130 426117007207 intersubunit interface [polypeptide binding]; other site 426117007208 active site 426117007209 Zn2+ binding site [ion binding]; other site 426117007210 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 426117007211 active site 426117007212 dimer interface [polypeptide binding]; other site 426117007213 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 426117007214 isocitrate dehydrogenase; Validated; Region: PRK08299 426117007215 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 426117007216 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 426117007217 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 426117007218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117007219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117007220 catalytic residue [active] 426117007221 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007223 active site 426117007224 phosphorylation site [posttranslational modification] 426117007225 intermolecular recognition site; other site 426117007226 dimerization interface [polypeptide binding]; other site 426117007227 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 426117007228 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426117007229 homodimer interface [polypeptide binding]; other site 426117007230 substrate-cofactor binding pocket; other site 426117007231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117007232 catalytic residue [active] 426117007233 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 426117007234 Low molecular weight phosphatase family; Region: LMWPc; cl00105 426117007235 active site 426117007236 hypothetical protein; Provisional; Region: PRK02853 426117007237 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 426117007238 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 426117007239 NAD binding site [chemical binding]; other site 426117007240 dimerization interface [polypeptide binding]; other site 426117007241 product binding site; other site 426117007242 substrate binding site [chemical binding]; other site 426117007243 zinc binding site [ion binding]; other site 426117007244 catalytic residues [active] 426117007245 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 426117007246 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 426117007247 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 426117007248 hinge; other site 426117007249 active site 426117007250 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426117007251 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 426117007252 substrate-cofactor binding pocket; other site 426117007253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117007254 catalytic residue [active] 426117007255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426117007256 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 426117007257 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 426117007258 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 426117007259 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117007260 motif 1; other site 426117007261 dimer interface [polypeptide binding]; other site 426117007262 active site 426117007263 motif 2; other site 426117007264 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117007265 active site 426117007266 motif 3; other site 426117007267 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 426117007268 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 426117007269 dimer interface [polypeptide binding]; other site 426117007270 motif 1; other site 426117007271 motif 2; other site 426117007272 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117007273 active site 426117007274 motif 3; other site 426117007275 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 426117007276 anticodon binding site; other site 426117007277 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 426117007278 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 426117007279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117007280 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426117007281 dimerization interface [polypeptide binding]; other site 426117007282 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 426117007283 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 426117007284 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 426117007285 GIY-YIG motif/motif A; other site 426117007286 active site 426117007287 catalytic site [active] 426117007288 putative DNA binding site [nucleotide binding]; other site 426117007289 metal binding site [ion binding]; metal-binding site 426117007290 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 426117007291 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 426117007292 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 426117007293 MoaE interaction surface [polypeptide binding]; other site 426117007294 MoeB interaction surface [polypeptide binding]; other site 426117007295 thiocarboxylated glycine; other site 426117007296 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 426117007297 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 426117007298 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 426117007299 metal binding site [ion binding]; metal-binding site 426117007300 Isochorismatase family; Region: Isochorismatase; pfam00857 426117007301 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426117007302 catalytic triad [active] 426117007303 conserved cis-peptide bond; other site 426117007304 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 426117007305 active site 426117007306 zinc binding site [ion binding]; other site 426117007307 Putative phosphatase (DUF442); Region: DUF442; cl17385 426117007308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117007309 Coenzyme A binding pocket [chemical binding]; other site 426117007310 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 426117007311 dimer interface [polypeptide binding]; other site 426117007312 substrate binding site [chemical binding]; other site 426117007313 metal binding sites [ion binding]; metal-binding site 426117007314 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426117007315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117007316 Coenzyme A binding pocket [chemical binding]; other site 426117007317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117007318 citrate-proton symporter; Provisional; Region: PRK15075 426117007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117007320 putative substrate translocation pore; other site 426117007321 hypothetical protein; Validated; Region: PRK09104 426117007322 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 426117007323 metal binding site [ion binding]; metal-binding site 426117007324 putative dimer interface [polypeptide binding]; other site 426117007325 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117007326 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426117007327 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117007328 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426117007329 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426117007330 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117007331 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117007332 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117007333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117007334 catalytic core [active] 426117007335 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 426117007336 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 426117007337 putative ligand binding site [chemical binding]; other site 426117007338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117007339 catalytic loop [active] 426117007340 iron binding site [ion binding]; other site 426117007341 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 426117007342 FAD binding pocket [chemical binding]; other site 426117007343 FAD binding motif [chemical binding]; other site 426117007344 phosphate binding motif [ion binding]; other site 426117007345 beta-alpha-beta structure motif; other site 426117007346 NAD binding pocket [chemical binding]; other site 426117007347 PBP superfamily domain; Region: PBP_like_2; pfam12849 426117007348 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 426117007349 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117007350 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 426117007351 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 426117007352 putative oligomer interface [polypeptide binding]; other site 426117007353 putative active site [active] 426117007354 metal binding site [ion binding]; metal-binding site 426117007355 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 426117007356 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117007357 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117007358 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 426117007359 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 426117007360 active site 426117007361 dimer interface [polypeptide binding]; other site 426117007362 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 426117007363 Ligand Binding Site [chemical binding]; other site 426117007364 Molecular Tunnel; other site 426117007365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117007366 dimer interface [polypeptide binding]; other site 426117007367 phosphorylation site [posttranslational modification] 426117007368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117007369 ATP binding site [chemical binding]; other site 426117007370 Mg2+ binding site [ion binding]; other site 426117007371 G-X-G motif; other site 426117007372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007373 active site 426117007374 phosphorylation site [posttranslational modification] 426117007375 intermolecular recognition site; other site 426117007376 dimerization interface [polypeptide binding]; other site 426117007377 PAS fold; Region: PAS_7; pfam12860 426117007378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007379 PAS fold; Region: PAS_3; pfam08447 426117007380 putative active site [active] 426117007381 heme pocket [chemical binding]; other site 426117007382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007383 PAS domain; Region: PAS_9; pfam13426 426117007384 putative active site [active] 426117007385 heme pocket [chemical binding]; other site 426117007386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117007387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117007388 dimer interface [polypeptide binding]; other site 426117007389 phosphorylation site [posttranslational modification] 426117007390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117007391 ATP binding site [chemical binding]; other site 426117007392 Mg2+ binding site [ion binding]; other site 426117007393 G-X-G motif; other site 426117007394 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007396 active site 426117007397 phosphorylation site [posttranslational modification] 426117007398 intermolecular recognition site; other site 426117007399 dimerization interface [polypeptide binding]; other site 426117007400 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426117007401 putative binding surface; other site 426117007402 active site 426117007403 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 426117007404 intersubunit interface [polypeptide binding]; other site 426117007405 active site 426117007406 Zn2+ binding site [ion binding]; other site 426117007407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117007408 S-adenosylmethionine binding site [chemical binding]; other site 426117007409 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426117007410 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 426117007411 active site 426117007412 FMN binding site [chemical binding]; other site 426117007413 substrate binding site [chemical binding]; other site 426117007414 homotetramer interface [polypeptide binding]; other site 426117007415 catalytic residue [active] 426117007416 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 426117007417 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 426117007418 acyl-activating enzyme (AAE) consensus motif; other site 426117007419 putative AMP binding site [chemical binding]; other site 426117007420 putative active site [active] 426117007421 putative CoA binding site [chemical binding]; other site 426117007422 acyl-CoA synthetase; Validated; Region: PRK08162 426117007423 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 426117007424 acyl-activating enzyme (AAE) consensus motif; other site 426117007425 putative active site [active] 426117007426 AMP binding site [chemical binding]; other site 426117007427 putative CoA binding site [chemical binding]; other site 426117007428 Uncharacterized small protein [Function unknown]; Region: COG5570 426117007429 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 426117007430 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 426117007431 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426117007432 NAD binding site [chemical binding]; other site 426117007433 ATP-grasp domain; Region: ATP-grasp; pfam02222 426117007434 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426117007435 Beta-lactamase; Region: Beta-lactamase; pfam00144 426117007436 TPR repeat; Region: TPR_11; pfam13414 426117007437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007438 binding surface 426117007439 TPR motif; other site 426117007440 TPR repeat; Region: TPR_11; pfam13414 426117007441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007442 binding surface 426117007443 TPR motif; other site 426117007444 Tetratricopeptide repeat; Region: TPR_16; pfam13432 426117007445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117007446 Coenzyme A binding pocket [chemical binding]; other site 426117007447 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 426117007448 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 426117007449 putative active site [active] 426117007450 homoserine dehydrogenase; Provisional; Region: PRK06349 426117007451 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 426117007452 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 426117007453 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 426117007454 putative catalytic site [active] 426117007455 putative phosphate binding site [ion binding]; other site 426117007456 active site 426117007457 metal binding site A [ion binding]; metal-binding site 426117007458 DNA binding site [nucleotide binding] 426117007459 putative AP binding site [nucleotide binding]; other site 426117007460 putative metal binding site B [ion binding]; other site 426117007461 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117007462 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426117007463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117007464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117007465 dimer interface [polypeptide binding]; other site 426117007466 conserved gate region; other site 426117007467 putative PBP binding loops; other site 426117007468 ABC-ATPase subunit interface; other site 426117007469 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 426117007470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117007471 dimer interface [polypeptide binding]; other site 426117007472 conserved gate region; other site 426117007473 putative PBP binding loops; other site 426117007474 ABC-ATPase subunit interface; other site 426117007475 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426117007476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117007477 Walker A/P-loop; other site 426117007478 ATP binding site [chemical binding]; other site 426117007479 Q-loop/lid; other site 426117007480 ABC transporter signature motif; other site 426117007481 Walker B; other site 426117007482 D-loop; other site 426117007483 H-loop/switch region; other site 426117007484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117007485 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426117007486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117007487 Walker A/P-loop; other site 426117007488 ATP binding site [chemical binding]; other site 426117007489 Q-loop/lid; other site 426117007490 ABC transporter signature motif; other site 426117007491 Walker B; other site 426117007492 D-loop; other site 426117007493 H-loop/switch region; other site 426117007494 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117007495 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 426117007496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117007497 dimerization interface [polypeptide binding]; other site 426117007498 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117007499 dimer interface [polypeptide binding]; other site 426117007500 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426117007501 putative CheW interface [polypeptide binding]; other site 426117007502 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 426117007503 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 426117007504 pyruvate phosphate dikinase; Provisional; Region: PRK09279 426117007505 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 426117007506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426117007507 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426117007508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117007509 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117007510 PAS domain; Region: PAS_9; pfam13426 426117007511 PAS domain S-box; Region: sensory_box; TIGR00229 426117007512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007513 putative active site [active] 426117007514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117007515 metal binding site [ion binding]; metal-binding site 426117007516 active site 426117007517 I-site; other site 426117007518 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117007519 hypothetical protein; Validated; Region: PRK07586 426117007520 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117007521 PYR/PP interface [polypeptide binding]; other site 426117007522 dimer interface [polypeptide binding]; other site 426117007523 TPP binding site [chemical binding]; other site 426117007524 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 426117007525 TPP-binding site [chemical binding]; other site 426117007526 dimer interface [polypeptide binding]; other site 426117007527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 426117007528 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 426117007529 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117007530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 426117007531 dimer interface [polypeptide binding]; other site 426117007532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117007533 metal binding site [ion binding]; metal-binding site 426117007534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117007535 classical (c) SDRs; Region: SDR_c; cd05233 426117007536 NAD(P) binding site [chemical binding]; other site 426117007537 active site 426117007538 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117007539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117007540 ligand binding site [chemical binding]; other site 426117007541 flexible hinge region; other site 426117007542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117007543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117007544 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 426117007545 Walker A/P-loop; other site 426117007546 ATP binding site [chemical binding]; other site 426117007547 Q-loop/lid; other site 426117007548 ABC transporter signature motif; other site 426117007549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117007550 ABC transporter signature motif; other site 426117007551 Walker B; other site 426117007552 General stress protein [General function prediction only]; Region: GsiB; COG3729 426117007553 two-component response regulator; Provisional; Region: PRK09191 426117007554 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 426117007555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007556 active site 426117007557 phosphorylation site [posttranslational modification] 426117007558 intermolecular recognition site; other site 426117007559 dimerization interface [polypeptide binding]; other site 426117007560 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 426117007561 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 426117007562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117007563 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 426117007564 putative acyl-CoA synthetase; Provisional; Region: PRK06018 426117007565 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 426117007566 dimer interface [polypeptide binding]; other site 426117007567 acyl-activating enzyme (AAE) consensus motif; other site 426117007568 putative active site [active] 426117007569 AMP binding site [chemical binding]; other site 426117007570 putative CoA binding site [chemical binding]; other site 426117007571 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 426117007572 TspO/MBR family; Region: TspO_MBR; pfam03073 426117007573 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 426117007574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117007575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117007576 substrate binding pocket [chemical binding]; other site 426117007577 membrane-bound complex binding site; other site 426117007578 hinge residues; other site 426117007579 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426117007580 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426117007581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117007582 dimer interface [polypeptide binding]; other site 426117007583 putative CheW interface [polypeptide binding]; other site 426117007584 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 426117007585 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426117007586 TPP-binding site [chemical binding]; other site 426117007587 dimer interface [polypeptide binding]; other site 426117007588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426117007589 PYR/PP interface [polypeptide binding]; other site 426117007590 dimer interface [polypeptide binding]; other site 426117007591 TPP binding site [chemical binding]; other site 426117007592 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 426117007593 DctM-like transporters; Region: DctM; pfam06808 426117007594 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 426117007595 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117007596 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426117007597 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117007598 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117007599 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 426117007600 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426117007601 PYR/PP interface [polypeptide binding]; other site 426117007602 dimer interface [polypeptide binding]; other site 426117007603 TPP binding site [chemical binding]; other site 426117007604 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426117007605 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426117007606 TPP-binding site [chemical binding]; other site 426117007607 dimer interface [polypeptide binding]; other site 426117007608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117007609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117007610 NAD(P) binding site [chemical binding]; other site 426117007611 active site 426117007612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426117007613 TPR motif; other site 426117007614 binding surface 426117007615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007616 binding surface 426117007617 TPR motif; other site 426117007618 TPR repeat; Region: TPR_11; pfam13414 426117007619 TPR repeat; Region: TPR_11; pfam13414 426117007620 TPR repeat; Region: TPR_11; pfam13414 426117007621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007622 binding surface 426117007623 TPR motif; other site 426117007624 TPR repeat; Region: TPR_11; pfam13414 426117007625 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 426117007626 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426117007627 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426117007628 substrate binding pocket [chemical binding]; other site 426117007629 chain length determination region; other site 426117007630 substrate-Mg2+ binding site; other site 426117007631 catalytic residues [active] 426117007632 aspartate-rich region 1; other site 426117007633 active site lid residues [active] 426117007634 aspartate-rich region 2; other site 426117007635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117007636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117007637 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117007638 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117007639 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117007640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117007641 Histidine kinase; Region: HisKA_2; pfam07568 426117007642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117007643 ATP binding site [chemical binding]; other site 426117007644 Mg2+ binding site [ion binding]; other site 426117007645 G-X-G motif; other site 426117007646 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 426117007647 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 426117007648 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 426117007649 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 426117007650 tandem repeat interface [polypeptide binding]; other site 426117007651 oligomer interface [polypeptide binding]; other site 426117007652 active site residues [active] 426117007653 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 426117007654 dimer interface [polypeptide binding]; other site 426117007655 motif 1; other site 426117007656 active site 426117007657 motif 2; other site 426117007658 motif 3; other site 426117007659 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 426117007660 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117007661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117007662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117007663 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117007665 S-adenosylmethionine binding site [chemical binding]; other site 426117007666 Cupin; Region: Cupin_6; pfam12852 426117007667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117007668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117007669 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 426117007670 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117007671 NAD(P) binding site [chemical binding]; other site 426117007672 catalytic residues [active] 426117007673 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 426117007674 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426117007675 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 426117007676 intersubunit interface [polypeptide binding]; other site 426117007677 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 426117007678 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426117007679 dimer interface [polypeptide binding]; other site 426117007680 putative PBP binding regions; other site 426117007681 ABC-ATPase subunit interface; other site 426117007682 Cytochrome c; Region: Cytochrom_C; cl11414 426117007683 Cytochrome c; Region: Cytochrom_C; cl11414 426117007684 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 426117007685 Cupin domain; Region: Cupin_2; pfam07883 426117007686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117007687 DNA binding site [nucleotide binding] 426117007688 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117007689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426117007690 TPR motif; other site 426117007691 binding surface 426117007692 Winged helix-turn helix; Region: HTH_29; pfam13551 426117007693 Homeodomain-like domain; Region: HTH_32; pfam13565 426117007694 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117007695 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 426117007696 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 426117007697 catalytic residues [active] 426117007698 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007700 active site 426117007701 phosphorylation site [posttranslational modification] 426117007702 intermolecular recognition site; other site 426117007703 dimerization interface [polypeptide binding]; other site 426117007704 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117007705 cyclase homology domain; Region: CHD; cd07302 426117007706 nucleotidyl binding site; other site 426117007707 metal binding site [ion binding]; metal-binding site 426117007708 dimer interface [polypeptide binding]; other site 426117007709 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117007710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117007711 Walker A motif; other site 426117007712 ATP binding site [chemical binding]; other site 426117007713 Walker B motif; other site 426117007714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117007715 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117007716 Integrase core domain; Region: rve; pfam00665 426117007717 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007719 active site 426117007720 phosphorylation site [posttranslational modification] 426117007721 intermolecular recognition site; other site 426117007722 dimerization interface [polypeptide binding]; other site 426117007723 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117007724 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117007725 Integrase core domain; Region: rve; pfam00665 426117007726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117007727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117007728 dimer interface [polypeptide binding]; other site 426117007729 phosphorylation site [posttranslational modification] 426117007730 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007732 active site 426117007733 phosphorylation site [posttranslational modification] 426117007734 intermolecular recognition site; other site 426117007735 dimerization interface [polypeptide binding]; other site 426117007736 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 426117007737 cyclase homology domain; Region: CHD; cd07302 426117007738 nucleotidyl binding site; other site 426117007739 metal binding site [ion binding]; metal-binding site 426117007740 dimer interface [polypeptide binding]; other site 426117007741 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007743 active site 426117007744 phosphorylation site [posttranslational modification] 426117007745 intermolecular recognition site; other site 426117007746 dimerization interface [polypeptide binding]; other site 426117007747 HAMP domain; Region: HAMP; pfam00672 426117007748 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426117007749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117007750 dimer interface [polypeptide binding]; other site 426117007751 phosphorylation site [posttranslational modification] 426117007752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117007753 ATP binding site [chemical binding]; other site 426117007754 G-X-G motif; other site 426117007755 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007757 active site 426117007758 phosphorylation site [posttranslational modification] 426117007759 intermolecular recognition site; other site 426117007760 dimerization interface [polypeptide binding]; other site 426117007761 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117007762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007763 active site 426117007764 phosphorylation site [posttranslational modification] 426117007765 intermolecular recognition site; other site 426117007766 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 426117007767 tricarballylate dehydrogenase; Validated; Region: PRK08274 426117007768 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 426117007769 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 426117007770 integrase; Provisional; Region: int; PHA02601 426117007771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117007772 active site 426117007773 DNA binding site [nucleotide binding] 426117007774 Int/Topo IB signature motif; other site 426117007775 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426117007776 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117007777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117007778 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117007779 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117007780 cyclase homology domain; Region: CHD; cd07302 426117007781 nucleotidyl binding site; other site 426117007782 metal binding site [ion binding]; metal-binding site 426117007783 dimer interface [polypeptide binding]; other site 426117007784 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117007785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007786 TPR motif; other site 426117007787 TPR repeat; Region: TPR_11; pfam13414 426117007788 binding surface 426117007789 TPR repeat; Region: TPR_11; pfam13414 426117007790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117007791 binding surface 426117007792 TPR motif; other site 426117007793 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117007794 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117007795 cyclase homology domain; Region: CHD; cd07302 426117007796 nucleotidyl binding site; other site 426117007797 metal binding site [ion binding]; metal-binding site 426117007798 dimer interface [polypeptide binding]; other site 426117007799 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117007800 PRC-barrel domain; Region: PRC; pfam05239 426117007801 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 426117007802 Mechanosensitive ion channel; Region: MS_channel; pfam00924 426117007803 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426117007804 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 426117007805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117007806 Ligand Binding Site [chemical binding]; other site 426117007807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117007808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117007809 metal binding site [ion binding]; metal-binding site 426117007810 active site 426117007811 I-site; other site 426117007812 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007814 active site 426117007815 phosphorylation site [posttranslational modification] 426117007816 intermolecular recognition site; other site 426117007817 dimerization interface [polypeptide binding]; other site 426117007818 PilZ domain; Region: PilZ; cl01260 426117007819 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 426117007820 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426117007821 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426117007822 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 426117007823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117007824 MarR family; Region: MarR; pfam01047 426117007825 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426117007826 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426117007827 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117007828 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 426117007829 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117007830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117007831 dimer interface [polypeptide binding]; other site 426117007832 conserved gate region; other site 426117007833 putative PBP binding loops; other site 426117007834 ABC-ATPase subunit interface; other site 426117007835 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117007836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117007837 dimer interface [polypeptide binding]; other site 426117007838 conserved gate region; other site 426117007839 putative PBP binding loops; other site 426117007840 ABC-ATPase subunit interface; other site 426117007841 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426117007842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117007843 Walker A/P-loop; other site 426117007844 ATP binding site [chemical binding]; other site 426117007845 Q-loop/lid; other site 426117007846 ABC transporter signature motif; other site 426117007847 Walker B; other site 426117007848 D-loop; other site 426117007849 H-loop/switch region; other site 426117007850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117007851 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426117007852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117007853 Walker A/P-loop; other site 426117007854 ATP binding site [chemical binding]; other site 426117007855 Q-loop/lid; other site 426117007856 ABC transporter signature motif; other site 426117007857 Walker B; other site 426117007858 D-loop; other site 426117007859 H-loop/switch region; other site 426117007860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426117007861 PAS fold; Region: PAS_4; pfam08448 426117007862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007863 PAS domain; Region: PAS_9; pfam13426 426117007864 putative active site [active] 426117007865 heme pocket [chemical binding]; other site 426117007866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426117007867 PAS fold; Region: PAS_3; pfam08447 426117007868 putative active site [active] 426117007869 heme pocket [chemical binding]; other site 426117007870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007871 PAS fold; Region: PAS_3; pfam08447 426117007872 putative active site [active] 426117007873 heme pocket [chemical binding]; other site 426117007874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117007875 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117007876 putative active site [active] 426117007877 heme pocket [chemical binding]; other site 426117007878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117007879 dimer interface [polypeptide binding]; other site 426117007880 phosphorylation site [posttranslational modification] 426117007881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117007882 ATP binding site [chemical binding]; other site 426117007883 Mg2+ binding site [ion binding]; other site 426117007884 G-X-G motif; other site 426117007885 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117007886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007887 active site 426117007888 phosphorylation site [posttranslational modification] 426117007889 intermolecular recognition site; other site 426117007890 dimerization interface [polypeptide binding]; other site 426117007891 Dodecin; Region: Dodecin; pfam07311 426117007892 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 426117007893 ApbE family; Region: ApbE; pfam02424 426117007894 NosL; Region: NosL; pfam05573 426117007895 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 426117007896 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426117007897 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426117007898 Walker A/P-loop; other site 426117007899 ATP binding site [chemical binding]; other site 426117007900 Q-loop/lid; other site 426117007901 ABC transporter signature motif; other site 426117007902 Walker B; other site 426117007903 D-loop; other site 426117007904 H-loop/switch region; other site 426117007905 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 426117007906 nitrous-oxide reductase; Validated; Region: PRK02888 426117007907 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117007908 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 426117007909 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 426117007910 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426117007911 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 426117007912 diiron binding motif [ion binding]; other site 426117007913 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 426117007914 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426117007915 heme-binding site [chemical binding]; other site 426117007916 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426117007917 FAD binding pocket [chemical binding]; other site 426117007918 FAD binding motif [chemical binding]; other site 426117007919 phosphate binding motif [ion binding]; other site 426117007920 beta-alpha-beta structure motif; other site 426117007921 NAD binding pocket [chemical binding]; other site 426117007922 Heme binding pocket [chemical binding]; other site 426117007923 Predicted transcriptional regulator [Transcription]; Region: COG1959 426117007924 Transcriptional regulator; Region: Rrf2; cl17282 426117007925 Response regulator receiver domain; Region: Response_reg; pfam00072 426117007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117007927 active site 426117007928 phosphorylation site [posttranslational modification] 426117007929 intermolecular recognition site; other site 426117007930 dimerization interface [polypeptide binding]; other site 426117007931 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 426117007932 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 426117007933 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 426117007934 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 426117007935 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 426117007936 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 426117007937 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 426117007938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117007939 active site 426117007940 Erythromycin esterase; Region: Erythro_esteras; pfam05139 426117007941 Protein required for attachment to host cells; Region: Host_attach; pfam10116 426117007942 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 426117007943 AMP-binding enzyme; Region: AMP-binding; pfam00501 426117007944 acyl-activating enzyme (AAE) consensus motif; other site 426117007945 active site 426117007946 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426117007947 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426117007948 putative acyl-acceptor binding pocket; other site 426117007949 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 426117007950 AMP-binding enzyme; Region: AMP-binding; pfam00501 426117007951 acyl-activating enzyme (AAE) consensus motif; other site 426117007952 putative AMP binding site [chemical binding]; other site 426117007953 putative active site [active] 426117007954 putative CoA binding site [chemical binding]; other site 426117007955 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426117007956 Cytochrome c; Region: Cytochrom_C; pfam00034 426117007957 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426117007958 Ligand Binding Site [chemical binding]; other site 426117007959 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117007960 Ligand Binding Site [chemical binding]; other site 426117007961 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426117007962 BON domain; Region: BON; pfam04972 426117007963 BON domain; Region: BON; pfam04972 426117007964 BON domain; Region: BON; pfam04972 426117007965 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117007966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117007967 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117007968 catalytic residues [active] 426117007969 catalytic nucleophile [active] 426117007970 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117007971 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117007972 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117007973 Synaptic Site I dimer interface [polypeptide binding]; other site 426117007974 DNA binding site [nucleotide binding] 426117007975 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426117007976 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426117007977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117007978 S-adenosylmethionine binding site [chemical binding]; other site 426117007979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117007980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117007981 S-adenosylmethionine binding site [chemical binding]; other site 426117007982 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 426117007983 active site 426117007984 TDP-binding site; other site 426117007985 acceptor substrate-binding pocket; other site 426117007986 homodimer interface [polypeptide binding]; other site 426117007987 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117007988 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117007989 Integrase core domain; Region: rve; pfam00665 426117007990 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 426117007991 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 426117007992 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117007993 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426117007994 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 426117007995 Uncharacterized conserved protein [Function unknown]; Region: COG3025 426117007996 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 426117007997 putative active site [active] 426117007998 putative metal binding residues [ion binding]; other site 426117007999 signature motif; other site 426117008000 putative triphosphate binding site [ion binding]; other site 426117008001 CHAD domain; Region: CHAD; pfam05235 426117008002 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 426117008003 active site 426117008004 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 426117008005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117008006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117008007 active site 426117008008 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 426117008009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117008010 Walker A/P-loop; other site 426117008011 ATP binding site [chemical binding]; other site 426117008012 Q-loop/lid; other site 426117008013 ABC transporter signature motif; other site 426117008014 Walker B; other site 426117008015 D-loop; other site 426117008016 H-loop/switch region; other site 426117008017 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 426117008018 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117008019 Walker A/P-loop; other site 426117008020 ATP binding site [chemical binding]; other site 426117008021 Q-loop/lid; other site 426117008022 ABC transporter signature motif; other site 426117008023 Walker B; other site 426117008024 D-loop; other site 426117008025 H-loop/switch region; other site 426117008026 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117008027 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 426117008028 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 426117008029 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 426117008030 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 426117008031 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 426117008032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117008033 DNA-binding site [nucleotide binding]; DNA binding site 426117008034 UTRA domain; Region: UTRA; pfam07702 426117008035 tellurium resistance terB-like protein; Region: terB_like; cd07177 426117008036 metal binding site [ion binding]; metal-binding site 426117008037 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426117008038 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426117008039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008040 dimer interface [polypeptide binding]; other site 426117008041 conserved gate region; other site 426117008042 ABC-ATPase subunit interface; other site 426117008043 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117008044 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 426117008045 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 426117008046 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 426117008047 Walker A/P-loop; other site 426117008048 ATP binding site [chemical binding]; other site 426117008049 Q-loop/lid; other site 426117008050 ABC transporter signature motif; other site 426117008051 Walker B; other site 426117008052 D-loop; other site 426117008053 H-loop/switch region; other site 426117008054 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 426117008055 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 426117008056 trimer interface [polypeptide binding]; other site 426117008057 active site 426117008058 substrate binding site [chemical binding]; other site 426117008059 CoA binding site [chemical binding]; other site 426117008060 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 426117008061 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 426117008062 G1 box; other site 426117008063 GTP/Mg2+ binding site [chemical binding]; other site 426117008064 G2 box; other site 426117008065 Switch I region; other site 426117008066 G3 box; other site 426117008067 Switch II region; other site 426117008068 G4 box; other site 426117008069 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 426117008070 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 426117008071 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 426117008072 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 426117008073 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426117008074 active site 426117008075 Int/Topo IB signature motif; other site 426117008076 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426117008077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426117008078 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 426117008079 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426117008080 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117008081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008082 dimer interface [polypeptide binding]; other site 426117008083 conserved gate region; other site 426117008084 putative PBP binding loops; other site 426117008085 ABC-ATPase subunit interface; other site 426117008086 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426117008087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008088 dimer interface [polypeptide binding]; other site 426117008089 conserved gate region; other site 426117008090 putative PBP binding loops; other site 426117008091 ABC-ATPase subunit interface; other site 426117008092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117008093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426117008094 Hint domain; Region: Hint_2; pfam13403 426117008095 Uncharacterized conserved protein [Function unknown]; Region: COG3391 426117008096 GcrA cell cycle regulator; Region: GcrA; cl11564 426117008097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117008098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117008099 dimer interface [polypeptide binding]; other site 426117008100 phosphorylation site [posttranslational modification] 426117008101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008102 ATP binding site [chemical binding]; other site 426117008103 Mg2+ binding site [ion binding]; other site 426117008104 G-X-G motif; other site 426117008105 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117008106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008107 active site 426117008108 phosphorylation site [posttranslational modification] 426117008109 intermolecular recognition site; other site 426117008110 dimerization interface [polypeptide binding]; other site 426117008111 FIST N domain; Region: FIST; pfam08495 426117008112 FIST C domain; Region: FIST_C; pfam10442 426117008113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117008114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008115 active site 426117008116 phosphorylation site [posttranslational modification] 426117008117 intermolecular recognition site; other site 426117008118 dimerization interface [polypeptide binding]; other site 426117008119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117008120 DNA binding residues [nucleotide binding] 426117008121 dimerization interface [polypeptide binding]; other site 426117008122 carbon starvation protein A; Provisional; Region: PRK15015 426117008123 Carbon starvation protein CstA; Region: CstA; pfam02554 426117008124 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 426117008125 Protein of unknown function (DUF466); Region: DUF466; pfam04328 426117008126 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426117008127 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 426117008128 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 426117008129 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 426117008130 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 426117008131 RNA binding site [nucleotide binding]; other site 426117008132 Phasin protein; Region: Phasin_2; cl11491 426117008133 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426117008134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117008135 putative active site [active] 426117008136 heme pocket [chemical binding]; other site 426117008137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117008138 dimer interface [polypeptide binding]; other site 426117008139 phosphorylation site [posttranslational modification] 426117008140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008141 ATP binding site [chemical binding]; other site 426117008142 Mg2+ binding site [ion binding]; other site 426117008143 G-X-G motif; other site 426117008144 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117008145 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117008146 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 426117008147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117008148 putative substrate translocation pore; other site 426117008149 acetyl-CoA synthetase; Provisional; Region: PRK00174 426117008150 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 426117008151 active site 426117008152 CoA binding site [chemical binding]; other site 426117008153 acyl-activating enzyme (AAE) consensus motif; other site 426117008154 AMP binding site [chemical binding]; other site 426117008155 acetate binding site [chemical binding]; other site 426117008156 Protein of unknown function, DUF485; Region: DUF485; pfam04341 426117008157 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 426117008158 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 426117008159 Na binding site [ion binding]; other site 426117008160 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 426117008161 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 426117008162 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117008163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117008164 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117008165 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 426117008166 SLBB domain; Region: SLBB; pfam10531 426117008167 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426117008168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117008169 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117008170 Cupin domain; Region: Cupin_2; pfam07883 426117008171 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 426117008172 pentamer interface [polypeptide binding]; other site 426117008173 dodecaamer interface [polypeptide binding]; other site 426117008174 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 426117008175 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 426117008176 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 426117008177 putative RNA binding site [nucleotide binding]; other site 426117008178 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 426117008179 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 426117008180 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 426117008181 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 426117008182 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 426117008183 purine monophosphate binding site [chemical binding]; other site 426117008184 dimer interface [polypeptide binding]; other site 426117008185 putative catalytic residues [active] 426117008186 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 426117008187 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 426117008188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117008189 metal binding site [ion binding]; metal-binding site 426117008190 active site 426117008191 I-site; other site 426117008192 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 426117008193 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117008194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117008195 Walker A/P-loop; other site 426117008196 ATP binding site [chemical binding]; other site 426117008197 Q-loop/lid; other site 426117008198 ABC transporter signature motif; other site 426117008199 Walker B; other site 426117008200 D-loop; other site 426117008201 H-loop/switch region; other site 426117008202 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117008203 Walker A/P-loop; other site 426117008204 ATP binding site [chemical binding]; other site 426117008205 Q-loop/lid; other site 426117008206 ABC transporter signature motif; other site 426117008207 Walker B; other site 426117008208 D-loop; other site 426117008209 H-loop/switch region; other site 426117008210 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117008211 hypothetical protein; Provisional; Region: PRK07079 426117008212 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 426117008213 metal binding site [ion binding]; metal-binding site 426117008214 putative dimer interface [polypeptide binding]; other site 426117008215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117008216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008217 ABC-ATPase subunit interface; other site 426117008218 putative PBP binding loops; other site 426117008219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117008220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008221 dimer interface [polypeptide binding]; other site 426117008222 conserved gate region; other site 426117008223 putative PBP binding loops; other site 426117008224 ABC-ATPase subunit interface; other site 426117008225 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 426117008226 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117008227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117008228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117008229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117008230 dimerization interface [polypeptide binding]; other site 426117008231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117008232 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117008233 DNA-binding site [nucleotide binding]; DNA binding site 426117008234 RNA-binding motif; other site 426117008235 Cytochrome c; Region: Cytochrom_C; cl11414 426117008236 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 426117008237 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 426117008238 Subunit I/III interface [polypeptide binding]; other site 426117008239 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 426117008240 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426117008241 D-pathway; other site 426117008242 Putative ubiquinol binding site [chemical binding]; other site 426117008243 Low-spin heme (heme b) binding site [chemical binding]; other site 426117008244 Putative water exit pathway; other site 426117008245 Binuclear center (heme o3/CuB) [ion binding]; other site 426117008246 K-pathway; other site 426117008247 Putative proton exit pathway; other site 426117008248 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117008249 Cytochrome c; Region: Cytochrom_C; pfam00034 426117008250 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426117008251 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 426117008252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117008253 substrate binding pocket [chemical binding]; other site 426117008254 membrane-bound complex binding site; other site 426117008255 hinge residues; other site 426117008256 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426117008257 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426117008258 Trp docking motif [polypeptide binding]; other site 426117008259 dimer interface [polypeptide binding]; other site 426117008260 active site 426117008261 small subunit binding site [polypeptide binding]; other site 426117008262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117008263 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426117008264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117008265 NAD(P) binding site [chemical binding]; other site 426117008266 active site 426117008267 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 426117008268 4Fe-4S binding domain; Region: Fer4; pfam00037 426117008269 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 426117008270 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117008271 PAS fold; Region: PAS_4; pfam08448 426117008272 PAS domain; Region: PAS_9; pfam13426 426117008273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117008274 HWE histidine kinase; Region: HWE_HK; smart00911 426117008275 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 426117008276 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117008277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117008278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117008279 catalytic residue [active] 426117008280 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117008281 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117008282 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117008283 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117008284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117008285 non-specific DNA binding site [nucleotide binding]; other site 426117008286 salt bridge; other site 426117008287 sequence-specific DNA binding site [nucleotide binding]; other site 426117008288 allantoate amidohydrolase; Reviewed; Region: PRK09290 426117008289 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426117008290 active site 426117008291 metal binding site [ion binding]; metal-binding site 426117008292 dimer interface [polypeptide binding]; other site 426117008293 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 426117008294 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 426117008295 heterodimer interface [polypeptide binding]; other site 426117008296 active site 426117008297 FMN binding site [chemical binding]; other site 426117008298 homodimer interface [polypeptide binding]; other site 426117008299 substrate binding site [chemical binding]; other site 426117008300 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 426117008301 FAD binding pocket [chemical binding]; other site 426117008302 FAD binding motif [chemical binding]; other site 426117008303 phosphate binding motif [ion binding]; other site 426117008304 beta-alpha-beta structure motif; other site 426117008305 NAD binding pocket [chemical binding]; other site 426117008306 Iron coordination center [ion binding]; other site 426117008307 benzoate transport; Region: 2A0115; TIGR00895 426117008308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117008309 putative substrate translocation pore; other site 426117008310 Cupin domain; Region: Cupin_2; cl17218 426117008311 ABC1 family; Region: ABC1; cl17513 426117008312 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 426117008313 Transglycosylase; Region: Transgly; cl17702 426117008314 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117008315 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117008316 putative ligand binding site [chemical binding]; other site 426117008317 Putative cyclase; Region: Cyclase; cl00814 426117008318 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783 426117008319 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 426117008320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117008321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117008322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117008323 Walker A/P-loop; other site 426117008324 ATP binding site [chemical binding]; other site 426117008325 Q-loop/lid; other site 426117008326 ABC transporter signature motif; other site 426117008327 Walker B; other site 426117008328 D-loop; other site 426117008329 H-loop/switch region; other site 426117008330 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 426117008331 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117008332 putative metal binding site; other site 426117008333 PAS fold; Region: PAS_4; pfam08448 426117008334 PAS fold; Region: PAS_3; pfam08447 426117008335 PAS fold; Region: PAS_7; pfam12860 426117008336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117008337 putative active site [active] 426117008338 heme pocket [chemical binding]; other site 426117008339 PAS domain S-box; Region: sensory_box; TIGR00229 426117008340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117008341 putative active site [active] 426117008342 heme pocket [chemical binding]; other site 426117008343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117008344 PAS fold; Region: PAS_3; pfam08447 426117008345 putative active site [active] 426117008346 heme pocket [chemical binding]; other site 426117008347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117008348 PAS domain; Region: PAS_9; pfam13426 426117008349 putative active site [active] 426117008350 heme pocket [chemical binding]; other site 426117008351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117008352 dimer interface [polypeptide binding]; other site 426117008353 phosphorylation site [posttranslational modification] 426117008354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008355 ATP binding site [chemical binding]; other site 426117008356 Mg2+ binding site [ion binding]; other site 426117008357 G-X-G motif; other site 426117008358 Response regulator receiver domain; Region: Response_reg; pfam00072 426117008359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008360 active site 426117008361 phosphorylation site [posttranslational modification] 426117008362 intermolecular recognition site; other site 426117008363 dimerization interface [polypeptide binding]; other site 426117008364 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 426117008365 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426117008366 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 426117008367 FAD binding domain; Region: FAD_binding_4; pfam01565 426117008368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117008369 S-adenosylmethionine binding site [chemical binding]; other site 426117008370 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426117008371 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426117008372 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117008373 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117008374 protein binding site [polypeptide binding]; other site 426117008375 PAS fold; Region: PAS_7; pfam12860 426117008376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117008377 dimer interface [polypeptide binding]; other site 426117008378 phosphorylation site [posttranslational modification] 426117008379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008380 ATP binding site [chemical binding]; other site 426117008381 Mg2+ binding site [ion binding]; other site 426117008382 G-X-G motif; other site 426117008383 Response regulator receiver domain; Region: Response_reg; pfam00072 426117008384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008385 active site 426117008386 phosphorylation site [posttranslational modification] 426117008387 intermolecular recognition site; other site 426117008388 dimerization interface [polypeptide binding]; other site 426117008389 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 426117008390 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 426117008391 active site 426117008392 substrate binding site [chemical binding]; other site 426117008393 coenzyme B12 binding site [chemical binding]; other site 426117008394 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 426117008395 B12 binding site [chemical binding]; other site 426117008396 cobalt ligand [ion binding]; other site 426117008397 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426117008398 Peptidase family M23; Region: Peptidase_M23; pfam01551 426117008399 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426117008400 putative active site [active] 426117008401 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117008402 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117008403 catalytic loop [active] 426117008404 iron binding site [ion binding]; other site 426117008405 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117008406 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117008407 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117008408 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117008409 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117008410 Cytochrome c; Region: Cytochrom_C; cl11414 426117008411 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 426117008412 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 426117008413 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 426117008414 UTRA domain; Region: UTRA; cl17743 426117008415 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 426117008416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117008418 Walker A/P-loop; other site 426117008419 ATP binding site [chemical binding]; other site 426117008420 Q-loop/lid; other site 426117008421 ABC transporter signature motif; other site 426117008422 Walker B; other site 426117008423 D-loop; other site 426117008424 H-loop/switch region; other site 426117008425 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 426117008426 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 426117008427 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 426117008428 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 426117008429 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117008430 ligand binding site [chemical binding]; other site 426117008431 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426117008432 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 426117008433 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 426117008434 Mechanosensitive ion channel; Region: MS_channel; pfam00924 426117008435 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 426117008436 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 426117008437 active site 426117008438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117008439 short chain dehydrogenase; Validated; Region: PRK07069 426117008440 NAD(P) binding site [chemical binding]; other site 426117008441 active site 426117008442 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426117008443 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426117008444 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426117008445 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 426117008446 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 426117008447 active site 426117008448 substrate binding site [chemical binding]; other site 426117008449 metal binding site [ion binding]; metal-binding site 426117008450 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117008451 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 426117008452 substrate binding site [chemical binding]; other site 426117008453 ATP binding site [chemical binding]; other site 426117008454 Entner-Doudoroff aldolase; Region: eda; TIGR01182 426117008455 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 426117008456 active site 426117008457 intersubunit interface [polypeptide binding]; other site 426117008458 catalytic residue [active] 426117008459 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 426117008460 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 426117008461 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 426117008462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117008463 putative active site [active] 426117008464 metal binding site [ion binding]; metal-binding site 426117008465 homodimer binding site [polypeptide binding]; other site 426117008466 hypothetical protein; Validated; Region: PRK09039 426117008467 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117008468 ligand binding site [chemical binding]; other site 426117008469 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 426117008470 homodimer interface [polypeptide binding]; other site 426117008471 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 426117008472 active site pocket [active] 426117008473 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 426117008474 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426117008475 active site 426117008476 catalytic site [active] 426117008477 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426117008478 glycogen synthase; Provisional; Region: glgA; PRK00654 426117008479 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 426117008480 ADP-binding pocket [chemical binding]; other site 426117008481 homodimer interface [polypeptide binding]; other site 426117008482 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426117008483 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426117008484 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 426117008485 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 426117008486 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 426117008487 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 426117008488 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 426117008489 [4Fe-4S] binding site [ion binding]; other site 426117008490 molybdopterin cofactor binding site; other site 426117008491 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117008492 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 426117008493 molybdopterin cofactor binding site; other site 426117008494 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426117008495 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 426117008496 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 426117008497 Predicted esterase [General function prediction only]; Region: COG0400 426117008498 putative hydrolase; Provisional; Region: PRK11460 426117008499 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 426117008500 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117008501 Zn binding site [ion binding]; other site 426117008502 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 426117008503 Zn binding site [ion binding]; other site 426117008504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117008505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117008506 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117008507 putative effector binding pocket; other site 426117008508 dimerization interface [polypeptide binding]; other site 426117008509 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 426117008510 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426117008511 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117008512 Sel1-like repeats; Region: SEL1; smart00671 426117008513 Sel1-like repeats; Region: SEL1; smart00671 426117008514 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 426117008515 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426117008516 DNA binding residues [nucleotide binding] 426117008517 putative dimer interface [polypeptide binding]; other site 426117008518 FOG: WD40 repeat [General function prediction only]; Region: COG2319 426117008519 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 426117008520 structural tetrad; other site 426117008521 Cytochrome c; Region: Cytochrom_C; cl11414 426117008522 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 426117008523 Lumazine binding domain; Region: Lum_binding; pfam00677 426117008524 Lumazine binding domain; Region: Lum_binding; pfam00677 426117008525 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 426117008526 catalytic motif [active] 426117008527 Zn binding site [ion binding]; other site 426117008528 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 426117008529 RibD C-terminal domain; Region: RibD_C; cl17279 426117008530 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 426117008531 ATP cone domain; Region: ATP-cone; pfam03477 426117008532 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 426117008533 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 426117008534 dimer interface [polypeptide binding]; other site 426117008535 active site 426117008536 glycine-pyridoxal phosphate binding site [chemical binding]; other site 426117008537 folate binding site [chemical binding]; other site 426117008538 SlyX; Region: SlyX; pfam04102 426117008539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426117008540 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117008541 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117008542 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 426117008543 Protein of unknown function (DUF461); Region: DUF461; pfam04314 426117008544 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 426117008545 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 426117008546 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 426117008547 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117008548 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117008549 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117008550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117008551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117008552 active site 426117008553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117008554 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 426117008555 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 426117008556 GSCFA family; Region: GSCFA; pfam08885 426117008557 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426117008558 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426117008559 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426117008560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117008561 P-loop; other site 426117008562 Magnesium ion binding site [ion binding]; other site 426117008563 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426117008564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117008565 DNA-binding site [nucleotide binding]; DNA binding site 426117008566 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 426117008567 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117008568 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117008569 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117008570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008571 dimer interface [polypeptide binding]; other site 426117008572 conserved gate region; other site 426117008573 putative PBP binding loops; other site 426117008574 ABC-ATPase subunit interface; other site 426117008575 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117008576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117008577 dimer interface [polypeptide binding]; other site 426117008578 conserved gate region; other site 426117008579 putative PBP binding loops; other site 426117008580 ABC-ATPase subunit interface; other site 426117008581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117008582 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117008583 Walker A/P-loop; other site 426117008584 ATP binding site [chemical binding]; other site 426117008585 Q-loop/lid; other site 426117008586 ABC transporter signature motif; other site 426117008587 Walker B; other site 426117008588 D-loop; other site 426117008589 H-loop/switch region; other site 426117008590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117008591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117008592 substrate binding pocket [chemical binding]; other site 426117008593 membrane-bound complex binding site; other site 426117008594 hinge residues; other site 426117008595 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 426117008596 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117008597 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 426117008598 substrate binding site [chemical binding]; other site 426117008599 dimer interface [polypeptide binding]; other site 426117008600 ATP binding site [chemical binding]; other site 426117008601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117008602 NAD(P) binding site [chemical binding]; other site 426117008603 active site 426117008604 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117008605 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117008606 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117008607 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117008608 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117008609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117008610 catalytic loop [active] 426117008611 iron binding site [ion binding]; other site 426117008612 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117008613 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426117008614 active site 426117008615 homotetramer interface [polypeptide binding]; other site 426117008616 homodimer interface [polypeptide binding]; other site 426117008617 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 426117008618 DHH family; Region: DHH; pfam01368 426117008619 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 426117008620 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 426117008621 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 426117008622 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 426117008623 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 426117008624 ligand binding site [chemical binding]; other site 426117008625 homodimer interface [polypeptide binding]; other site 426117008626 NAD(P) binding site [chemical binding]; other site 426117008627 trimer interface B [polypeptide binding]; other site 426117008628 trimer interface A [polypeptide binding]; other site 426117008629 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 426117008630 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 426117008631 ABC1 family; Region: ABC1; cl17513 426117008632 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 426117008633 putative homodimer interface [polypeptide binding]; other site 426117008634 putative homotetramer interface [polypeptide binding]; other site 426117008635 putative allosteric switch controlling residues; other site 426117008636 putative metal binding site [ion binding]; other site 426117008637 putative homodimer-homodimer interface [polypeptide binding]; other site 426117008638 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 426117008639 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 426117008640 active site 426117008641 Zn binding site [ion binding]; other site 426117008642 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426117008643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008644 active site 426117008645 phosphorylation site [posttranslational modification] 426117008646 intermolecular recognition site; other site 426117008647 dimerization interface [polypeptide binding]; other site 426117008648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117008649 Walker A motif; other site 426117008650 ATP binding site [chemical binding]; other site 426117008651 Walker B motif; other site 426117008652 arginine finger; other site 426117008653 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117008654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426117008655 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117008656 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117008657 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117008658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 426117008659 Peptidase M15; Region: Peptidase_M15_3; cl01194 426117008660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426117008661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426117008662 Walker A/P-loop; other site 426117008663 ATP binding site [chemical binding]; other site 426117008664 Q-loop/lid; other site 426117008665 ABC transporter signature motif; other site 426117008666 Walker B; other site 426117008667 D-loop; other site 426117008668 H-loop/switch region; other site 426117008669 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426117008670 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426117008671 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 426117008672 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117008673 putative C-terminal domain interface [polypeptide binding]; other site 426117008674 putative GSH binding site (G-site) [chemical binding]; other site 426117008675 putative dimer interface [polypeptide binding]; other site 426117008676 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 426117008677 putative N-terminal domain interface [polypeptide binding]; other site 426117008678 putative substrate binding pocket (H-site) [chemical binding]; other site 426117008679 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 426117008680 catalytic core [active] 426117008681 phytoene desaturase; Region: crtI_fam; TIGR02734 426117008682 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 426117008683 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426117008684 putative acyl-acceptor binding pocket; other site 426117008685 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117008686 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 426117008687 active site 426117008688 putative amidase; Provisional; Region: PRK06169 426117008689 Amidase; Region: Amidase; cl11426 426117008690 Uncharacterized conserved protein [Function unknown]; Region: COG1656 426117008691 Domain of unknown function (DUF427); Region: DUF427; pfam04248 426117008692 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 426117008693 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 426117008694 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 426117008695 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 426117008696 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426117008697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117008698 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117008699 Walker A/P-loop; other site 426117008700 ATP binding site [chemical binding]; other site 426117008701 Q-loop/lid; other site 426117008702 ABC transporter signature motif; other site 426117008703 Walker B; other site 426117008704 D-loop; other site 426117008705 H-loop/switch region; other site 426117008706 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117008707 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117008708 Walker A/P-loop; other site 426117008709 ATP binding site [chemical binding]; other site 426117008710 Q-loop/lid; other site 426117008711 ABC transporter signature motif; other site 426117008712 Walker B; other site 426117008713 D-loop; other site 426117008714 H-loop/switch region; other site 426117008715 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117008716 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117008717 TM-ABC transporter signature motif; other site 426117008718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117008719 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117008720 TM-ABC transporter signature motif; other site 426117008721 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117008722 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 426117008723 putative ligand binding site [chemical binding]; other site 426117008724 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 426117008725 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426117008726 Bacterial transcriptional regulator; Region: IclR; pfam01614 426117008727 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 426117008728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117008729 non-specific DNA binding site [nucleotide binding]; other site 426117008730 salt bridge; other site 426117008731 sequence-specific DNA binding site [nucleotide binding]; other site 426117008732 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 426117008733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426117008734 classical (c) SDRs; Region: SDR_c; cd05233 426117008735 NAD(P) binding site [chemical binding]; other site 426117008736 active site 426117008737 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117008738 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117008739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117008740 sequence-specific DNA binding site [nucleotide binding]; other site 426117008741 salt bridge; other site 426117008742 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 426117008743 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 426117008744 putative active site [active] 426117008745 catalytic triad [active] 426117008746 putative dimer interface [polypeptide binding]; other site 426117008747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426117008748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426117008749 Transporter associated domain; Region: CorC_HlyC; smart01091 426117008750 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 426117008751 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 426117008752 PhoH-like protein; Region: PhoH; pfam02562 426117008753 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 426117008754 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426117008755 TRAM domain; Region: TRAM; cl01282 426117008756 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 426117008757 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426117008758 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426117008759 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426117008760 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117008761 NAD(P) binding site [chemical binding]; other site 426117008762 catalytic residues [active] 426117008763 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426117008764 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 426117008765 metal binding site [ion binding]; metal-binding site 426117008766 putative dimer interface [polypeptide binding]; other site 426117008767 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 426117008768 active site 426117008769 catalytic residues [active] 426117008770 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 426117008771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117008772 active site 426117008773 DNA binding site [nucleotide binding] 426117008774 Int/Topo IB signature motif; other site 426117008775 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 426117008776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117008777 Walker A/P-loop; other site 426117008778 ATP binding site [chemical binding]; other site 426117008779 Q-loop/lid; other site 426117008780 ABC transporter signature motif; other site 426117008781 Walker B; other site 426117008782 D-loop; other site 426117008783 H-loop/switch region; other site 426117008784 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 426117008785 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 426117008786 putative ligand binding site [chemical binding]; other site 426117008787 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 426117008788 photoactive yellow protein; Region: photo_yellow; TIGR02373 426117008789 PAS fold; Region: PAS; pfam00989 426117008790 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 426117008791 GAF domain; Region: GAF; pfam01590 426117008792 Phytochrome region; Region: PHY; pfam00360 426117008793 Histidine kinase; Region: HisKA_2; pfam07568 426117008794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008795 ATP binding site [chemical binding]; other site 426117008796 Mg2+ binding site [ion binding]; other site 426117008797 G-X-G motif; other site 426117008798 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 426117008799 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 426117008800 catalytic site [active] 426117008801 G-X2-G-X-G-K; other site 426117008802 hypothetical protein; Provisional; Region: PRK11820 426117008803 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 426117008804 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 426117008805 YceG-like family; Region: YceG; pfam02618 426117008806 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 426117008807 dimerization interface [polypeptide binding]; other site 426117008808 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 426117008809 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426117008810 dimer interface [polypeptide binding]; other site 426117008811 active site 426117008812 acyl carrier protein; Provisional; Region: acpP; PRK00982 426117008813 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 426117008814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117008815 NAD(P) binding site [chemical binding]; other site 426117008816 active site 426117008817 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 426117008818 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426117008819 Bacitracin resistance protein BacA; Region: BacA; pfam02673 426117008820 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 426117008821 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 426117008822 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 426117008823 ThiC-associated domain; Region: ThiC-associated; pfam13667 426117008824 ThiC family; Region: ThiC; pfam01964 426117008825 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 426117008826 Predicted membrane protein [Function unknown]; Region: COG4763 426117008827 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426117008828 Yqey-like protein; Region: YqeY; pfam09424 426117008829 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 426117008830 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 426117008831 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 426117008832 catalytic site [active] 426117008833 subunit interface [polypeptide binding]; other site 426117008834 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117008835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117008836 NAD(P) binding site [chemical binding]; other site 426117008837 active site 426117008838 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 426117008839 flagellar motor protein MotA; Validated; Region: PRK09110 426117008840 Flagellar motor switch protein FliM; Region: FliM; pfam02154 426117008841 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 426117008842 flagellar motor switch protein FliN; Region: fliN; TIGR02480 426117008843 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 426117008844 FliG C-terminal domain; Region: FliG_C; pfam01706 426117008845 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 426117008846 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 426117008847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117008848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426117008849 active site 426117008850 dimerization interface [polypeptide binding]; other site 426117008851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117008852 DNA binding site [nucleotide binding] 426117008853 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117008854 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117008855 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117008856 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 426117008857 chemotaxis protein; Reviewed; Region: PRK12798 426117008858 flagellar motor protein MotB; Validated; Region: motB; PRK05996 426117008859 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 426117008860 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426117008861 ligand binding site [chemical binding]; other site 426117008862 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 426117008863 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 426117008864 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 426117008865 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 426117008866 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426117008867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117008868 FeS/SAM binding site; other site 426117008869 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 426117008870 Isochorismatase family; Region: Isochorismatase; pfam00857 426117008871 catalytic triad [active] 426117008872 metal binding site [ion binding]; metal-binding site 426117008873 conserved cis-peptide bond; other site 426117008874 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 426117008875 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 426117008876 NADP binding site [chemical binding]; other site 426117008877 dimer interface [polypeptide binding]; other site 426117008878 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 426117008879 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117008880 hypothetical protein; Provisional; Region: PRK10279 426117008881 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426117008882 nucleophile elbow; other site 426117008883 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 426117008884 FOG: CBS domain [General function prediction only]; Region: COG0517 426117008885 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 426117008886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 426117008887 PilZ domain; Region: PilZ; pfam07238 426117008888 PilZ domain; Region: PilZ; pfam07238 426117008889 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 426117008890 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 426117008891 Potassium binding sites [ion binding]; other site 426117008892 Cesium cation binding sites [ion binding]; other site 426117008893 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 426117008894 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117008895 inhibitor-cofactor binding pocket; inhibition site 426117008896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117008897 catalytic residue [active] 426117008898 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 426117008899 putative dimer interface [polypeptide binding]; other site 426117008900 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117008901 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117008902 TM-ABC transporter signature motif; other site 426117008903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117008904 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117008905 TM-ABC transporter signature motif; other site 426117008906 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117008907 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117008908 putative ligand binding site [chemical binding]; other site 426117008909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117008910 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117008911 Walker A/P-loop; other site 426117008912 ATP binding site [chemical binding]; other site 426117008913 Q-loop/lid; other site 426117008914 ABC transporter signature motif; other site 426117008915 Walker B; other site 426117008916 D-loop; other site 426117008917 H-loop/switch region; other site 426117008918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117008919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117008920 Walker A/P-loop; other site 426117008921 ATP binding site [chemical binding]; other site 426117008922 Q-loop/lid; other site 426117008923 ABC transporter signature motif; other site 426117008924 Walker B; other site 426117008925 D-loop; other site 426117008926 H-loop/switch region; other site 426117008927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117008928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117008929 putative substrate translocation pore; other site 426117008930 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 426117008931 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 426117008932 putative active site pocket [active] 426117008933 dimerization interface [polypeptide binding]; other site 426117008934 putative catalytic residue [active] 426117008935 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 426117008936 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426117008937 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 426117008938 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426117008939 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 426117008940 active site 426117008941 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117008942 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117008943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117008944 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117008945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117008946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117008947 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 426117008948 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 426117008949 PAS fold; Region: PAS_7; pfam12860 426117008950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117008951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117008952 dimer interface [polypeptide binding]; other site 426117008953 phosphorylation site [posttranslational modification] 426117008954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117008955 ATP binding site [chemical binding]; other site 426117008956 Mg2+ binding site [ion binding]; other site 426117008957 G-X-G motif; other site 426117008958 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117008959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117008960 active site 426117008961 phosphorylation site [posttranslational modification] 426117008962 intermolecular recognition site; other site 426117008963 Predicted transcriptional regulator [Transcription]; Region: COG2932 426117008964 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426117008965 Catalytic site [active] 426117008966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 426117008967 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 426117008968 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 426117008969 active site 426117008970 catalytic residues [active] 426117008971 FMN binding site [chemical binding]; other site 426117008972 quinone interaction residues [chemical binding]; other site 426117008973 substrate binding site [chemical binding]; other site 426117008974 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 426117008975 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 426117008976 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117008977 FlaG protein; Region: FlaG; cl00591 426117008978 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 426117008979 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 426117008980 active site pocket [active] 426117008981 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117008982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117008983 putative substrate translocation pore; other site 426117008984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117008985 galactarate dehydratase; Region: galactar-dH20; TIGR03248 426117008986 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 426117008987 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 426117008988 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 426117008989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117008990 catalytic loop [active] 426117008991 iron binding site [ion binding]; other site 426117008992 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 426117008993 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 426117008994 [4Fe-4S] binding site [ion binding]; other site 426117008995 molybdopterin cofactor binding site; other site 426117008996 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 426117008997 molybdopterin cofactor binding site; other site 426117008998 NADH dehydrogenase subunit E; Validated; Region: PRK07539 426117008999 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 426117009000 putative dimer interface [polypeptide binding]; other site 426117009001 [2Fe-2S] cluster binding site [ion binding]; other site 426117009002 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 426117009003 SLBB domain; Region: SLBB; pfam10531 426117009004 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 426117009005 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 426117009006 Low-spin heme binding site [chemical binding]; other site 426117009007 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 426117009008 Putative water exit pathway; other site 426117009009 Binuclear center (active site) [active] 426117009010 Putative proton exit pathway; other site 426117009011 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 426117009012 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 426117009013 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 426117009014 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 426117009015 Cytochrome c; Region: Cytochrom_C; pfam00034 426117009016 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426117009017 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426117009018 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426117009019 dimer interface [polypeptide binding]; other site 426117009020 putative functional site; other site 426117009021 putative MPT binding site; other site 426117009022 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 426117009023 Walker A motif; other site 426117009024 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 426117009025 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426117009026 dimer interface [polypeptide binding]; other site 426117009027 putative functional site; other site 426117009028 putative MPT binding site; other site 426117009029 PBP superfamily domain; Region: PBP_like; pfam12727 426117009030 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 426117009031 MPT binding site; other site 426117009032 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 426117009033 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 426117009034 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 426117009035 FAD binding site [chemical binding]; other site 426117009036 substrate binding site [chemical binding]; other site 426117009037 catalytic residues [active] 426117009038 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 426117009039 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 426117009040 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426117009041 dimer interface [polypeptide binding]; other site 426117009042 active site 426117009043 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 426117009044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117009045 substrate binding site [chemical binding]; other site 426117009046 oxyanion hole (OAH) forming residues; other site 426117009047 trimer interface [polypeptide binding]; other site 426117009048 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117009049 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117009050 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 426117009051 homotrimer interaction site [polypeptide binding]; other site 426117009052 putative active site [active] 426117009053 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117009054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117009055 putative substrate translocation pore; other site 426117009056 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 426117009057 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 426117009058 tetramer interface [polypeptide binding]; other site 426117009059 heme binding pocket [chemical binding]; other site 426117009060 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 426117009061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117009062 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 426117009063 dimerization interface [polypeptide binding]; other site 426117009064 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426117009065 Putative ammonia monooxygenase; Region: AmoA; pfam05145 426117009066 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426117009067 threonine dehydratase; Reviewed; Region: PRK09224 426117009068 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426117009069 tetramer interface [polypeptide binding]; other site 426117009070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117009071 catalytic residue [active] 426117009072 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 426117009073 putative Ile/Val binding site [chemical binding]; other site 426117009074 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 426117009075 putative Ile/Val binding site [chemical binding]; other site 426117009076 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 426117009077 Uncharacterized conserved protein [Function unknown]; Region: COG1565 426117009078 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 426117009079 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 426117009080 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 426117009081 dimerization interface [polypeptide binding]; other site 426117009082 metal binding site [ion binding]; metal-binding site 426117009083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117009084 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 426117009085 putative metal binding site [ion binding]; other site 426117009086 Glucokinase; Region: Glucokinase; cl17310 426117009087 glucokinase, proteobacterial type; Region: glk; TIGR00749 426117009088 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 426117009089 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117009090 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117009091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117009092 DNA-binding site [nucleotide binding]; DNA binding site 426117009093 transcriptional regulator NanR; Provisional; Region: PRK03837 426117009094 FCD domain; Region: FCD; pfam07729 426117009095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117009096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117009097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117009098 dimerization interface [polypeptide binding]; other site 426117009099 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426117009100 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426117009101 inhibitor site; inhibition site 426117009102 active site 426117009103 dimer interface [polypeptide binding]; other site 426117009104 catalytic residue [active] 426117009105 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 426117009106 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117009107 choline dehydrogenase; Validated; Region: PRK02106 426117009108 TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF7; cl04653 426117009109 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426117009110 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426117009111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117009112 active site 426117009113 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117009114 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 426117009115 putative active site [active] 426117009116 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 426117009117 putative active site [active] 426117009118 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117009119 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117009120 active site 426117009121 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117009122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117009123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117009124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117009125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117009126 Walker A/P-loop; other site 426117009127 ATP binding site [chemical binding]; other site 426117009128 Q-loop/lid; other site 426117009129 ABC transporter signature motif; other site 426117009130 Walker B; other site 426117009131 D-loop; other site 426117009132 H-loop/switch region; other site 426117009133 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117009134 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117009135 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009136 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 426117009137 active site 426117009138 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 426117009139 homodimer interface [polypeptide binding]; other site 426117009140 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 426117009141 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 426117009142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117009143 putative CheW interface [polypeptide binding]; other site 426117009144 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 426117009145 DNA binding residues [nucleotide binding] 426117009146 dimerization interface [polypeptide binding]; other site 426117009147 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426117009148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117009149 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426117009150 Walker A/P-loop; other site 426117009151 ATP binding site [chemical binding]; other site 426117009152 Q-loop/lid; other site 426117009153 ABC transporter signature motif; other site 426117009154 Walker B; other site 426117009155 D-loop; other site 426117009156 H-loop/switch region; other site 426117009157 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117009158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426117009159 carboxyltransferase (CT) interaction site; other site 426117009160 biotinylation site [posttranslational modification]; other site 426117009161 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009162 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 426117009163 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 426117009164 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 426117009165 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 426117009166 PAS fold; Region: PAS_7; pfam12860 426117009167 PAS domain; Region: PAS; smart00091 426117009168 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117009169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117009170 putative active site [active] 426117009171 heme pocket [chemical binding]; other site 426117009172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117009173 dimer interface [polypeptide binding]; other site 426117009174 phosphorylation site [posttranslational modification] 426117009175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117009176 ATP binding site [chemical binding]; other site 426117009177 Mg2+ binding site [ion binding]; other site 426117009178 G-X-G motif; other site 426117009179 Response regulator receiver domain; Region: Response_reg; pfam00072 426117009180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009181 active site 426117009182 phosphorylation site [posttranslational modification] 426117009183 intermolecular recognition site; other site 426117009184 dimerization interface [polypeptide binding]; other site 426117009185 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 426117009186 active site clefts [active] 426117009187 zinc binding site [ion binding]; other site 426117009188 dimer interface [polypeptide binding]; other site 426117009189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 426117009190 active site 426117009191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117009192 non-specific DNA binding site [nucleotide binding]; other site 426117009193 salt bridge; other site 426117009194 sequence-specific DNA binding site [nucleotide binding]; other site 426117009195 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009196 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009197 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009198 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009199 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009200 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009201 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009202 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009203 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009204 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009205 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009206 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009207 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009208 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009209 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009210 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009211 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009212 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009213 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009214 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009215 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009216 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009217 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009218 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009219 VCBS repeat; Region: VCBS_repeat; TIGR01965 426117009220 Flp/Fap pilin component; Region: Flp_Fap; cl01585 426117009221 HTH-like domain; Region: HTH_21; pfam13276 426117009222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 426117009223 Integrase core domain; Region: rve; pfam00665 426117009224 Integrase core domain; Region: rve_3; pfam13683 426117009225 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 426117009226 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117009227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009229 active site 426117009230 phosphorylation site [posttranslational modification] 426117009231 intermolecular recognition site; other site 426117009232 dimerization interface [polypeptide binding]; other site 426117009233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117009234 DNA binding residues [nucleotide binding] 426117009235 dimerization interface [polypeptide binding]; other site 426117009236 CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611 426117009237 Bacterial SH3 domain; Region: SH3_3; pfam08239 426117009238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426117009239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117009240 P-loop; other site 426117009241 Magnesium ion binding site [ion binding]; other site 426117009242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117009243 active site 426117009244 DNA binding site [nucleotide binding] 426117009245 Int/Topo IB signature motif; other site 426117009246 Protein of unknown function (DUF992); Region: DUF992; pfam06186 426117009247 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426117009248 IHF - DNA interface [nucleotide binding]; other site 426117009249 IHF dimer interface [polypeptide binding]; other site 426117009250 Winged helix-turn helix; Region: HTH_29; pfam13551 426117009251 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117009252 Homeodomain-like domain; Region: HTH_32; pfam13565 426117009253 Integrase core domain; Region: rve; pfam00665 426117009254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 426117009255 Integrase core domain; Region: rve_3; pfam13683 426117009256 Ion channel; Region: Ion_trans_2; pfam07885 426117009257 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117009258 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117009259 Integrase core domain; Region: rve; pfam00665 426117009260 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 426117009261 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 426117009262 Winged helix-turn helix; Region: HTH_29; pfam13551 426117009263 Integrase core domain; Region: rve; pfam00665 426117009264 Integrase core domain; Region: rve_3; pfam13683 426117009265 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117009266 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 426117009267 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 426117009268 DXD motif; other site 426117009269 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 426117009270 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009271 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 426117009272 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 426117009273 glutaminase active site [active] 426117009274 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 426117009275 dimer interface [polypeptide binding]; other site 426117009276 active site 426117009277 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 426117009278 dimer interface [polypeptide binding]; other site 426117009279 active site 426117009280 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426117009281 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426117009282 Walker A/P-loop; other site 426117009283 ATP binding site [chemical binding]; other site 426117009284 Q-loop/lid; other site 426117009285 ABC transporter signature motif; other site 426117009286 Walker B; other site 426117009287 D-loop; other site 426117009288 H-loop/switch region; other site 426117009289 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117009290 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117009291 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117009293 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 426117009294 translocation protein TolB; Provisional; Region: tolB; PRK05137 426117009295 TolB amino-terminal domain; Region: TolB_N; pfam04052 426117009296 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117009297 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117009298 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117009299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117009300 TolR protein; Region: tolR; TIGR02801 426117009301 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426117009302 TolQ protein; Region: tolQ; TIGR02796 426117009303 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426117009304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426117009305 putative acyl-acceptor binding pocket; other site 426117009306 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 426117009307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117009308 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 426117009309 Glycoprotease family; Region: Peptidase_M22; pfam00814 426117009310 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 426117009311 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 426117009312 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 426117009313 Predicted membrane protein [Function unknown]; Region: COG2246 426117009314 GtrA-like protein; Region: GtrA; pfam04138 426117009315 classical (c) SDRs; Region: SDR_c; cd05233 426117009316 NAD(P) binding site [chemical binding]; other site 426117009317 active site 426117009318 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 426117009319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426117009320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117009321 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 426117009322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426117009323 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117009324 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 426117009325 IMP binding site; other site 426117009326 dimer interface [polypeptide binding]; other site 426117009327 partial ornithine binding site; other site 426117009328 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 426117009329 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 426117009330 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 426117009331 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 426117009332 dimer interface [polypeptide binding]; other site 426117009333 motif 1; other site 426117009334 active site 426117009335 motif 2; other site 426117009336 motif 3; other site 426117009337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117009338 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 426117009339 acyl carrier protein; Provisional; Region: PRK07081 426117009340 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 426117009341 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117009342 active site 426117009343 AMP binding site [chemical binding]; other site 426117009344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117009345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117009346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117009347 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117009348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117009349 active site 426117009350 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426117009351 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426117009352 active site 426117009353 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 426117009354 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 426117009355 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426117009356 P loop; other site 426117009357 GTP binding site [chemical binding]; other site 426117009358 intracellular septation protein A; Reviewed; Region: PRK00259 426117009359 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426117009360 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426117009361 minor groove reading motif; other site 426117009362 helix-hairpin-helix signature motif; other site 426117009363 substrate binding pocket [chemical binding]; other site 426117009364 active site 426117009365 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 426117009366 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 426117009367 active site 426117009368 HIGH motif; other site 426117009369 dimer interface [polypeptide binding]; other site 426117009370 KMSKS motif; other site 426117009371 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 426117009372 ketol-acid reductoisomerase; Provisional; Region: PRK05479 426117009373 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 426117009374 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 426117009375 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 426117009376 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426117009377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117009378 ATP binding site [chemical binding]; other site 426117009379 putative Mg++ binding site [ion binding]; other site 426117009380 nucleotide binding region [chemical binding]; other site 426117009381 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 426117009382 ATP-binding site [chemical binding]; other site 426117009383 Double zinc ribbon; Region: DZR; pfam12773 426117009384 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 426117009385 heme-binding site [chemical binding]; other site 426117009386 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 426117009387 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 426117009388 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 426117009389 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426117009390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117009391 D-galactonate transporter; Region: 2A0114; TIGR00893 426117009392 putative substrate translocation pore; other site 426117009393 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117009394 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117009395 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117009396 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117009397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117009398 dimer interface [polypeptide binding]; other site 426117009399 putative CheW interface [polypeptide binding]; other site 426117009400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117009401 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426117009402 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117009403 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 426117009404 putative substrate binding site [chemical binding]; other site 426117009405 putative ATP binding site [chemical binding]; other site 426117009406 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 426117009407 regulatory phosphorylation site [posttranslational modification]; other site 426117009408 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 426117009409 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 426117009410 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426117009411 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426117009412 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 426117009413 HPr interaction site; other site 426117009414 glycerol kinase (GK) interaction site [polypeptide binding]; other site 426117009415 active site 426117009416 phosphorylation site [posttranslational modification] 426117009417 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 426117009418 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 426117009419 substrate binding [chemical binding]; other site 426117009420 active site 426117009421 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 426117009422 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 426117009423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426117009424 active site turn [active] 426117009425 phosphorylation site [posttranslational modification] 426117009426 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426117009427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426117009428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426117009429 DNA binding site [nucleotide binding] 426117009430 domain linker motif; other site 426117009431 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 426117009432 dimerization interface [polypeptide binding]; other site 426117009433 ligand binding site [chemical binding]; other site 426117009434 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426117009435 RNA polymerase sigma factor; Provisional; Region: PRK12528 426117009436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117009437 DNA binding residues [nucleotide binding] 426117009438 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 426117009439 FecR protein; Region: FecR; pfam04773 426117009440 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 426117009441 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 426117009442 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 426117009443 Secretin and TonB N terminus short domain; Region: STN; smart00965 426117009444 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426117009445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426117009446 N-terminal plug; other site 426117009447 ligand-binding site [chemical binding]; other site 426117009448 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426117009449 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 426117009450 substrate-cofactor binding pocket; other site 426117009451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117009452 catalytic residue [active] 426117009453 NnrU protein; Region: NnrU; pfam07298 426117009454 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426117009455 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426117009456 dimer interface [polypeptide binding]; other site 426117009457 putative functional site; other site 426117009458 putative MPT binding site; other site 426117009459 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 426117009460 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 426117009461 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426117009462 N-terminal plug; other site 426117009463 ligand-binding site [chemical binding]; other site 426117009464 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426117009465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426117009466 NMT1-like family; Region: NMT1_2; pfam13379 426117009467 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117009468 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117009469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117009470 Walker A/P-loop; other site 426117009471 ATP binding site [chemical binding]; other site 426117009472 Q-loop/lid; other site 426117009473 ABC transporter signature motif; other site 426117009474 Walker B; other site 426117009475 D-loop; other site 426117009476 H-loop/switch region; other site 426117009477 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117009478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117009479 putative PBP binding loops; other site 426117009480 ABC-ATPase subunit interface; other site 426117009481 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426117009482 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426117009483 active site 426117009484 non-prolyl cis peptide bond; other site 426117009485 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426117009486 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 426117009487 homodimer interface [polypeptide binding]; other site 426117009488 substrate-cofactor binding pocket; other site 426117009489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117009490 catalytic residue [active] 426117009491 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117009492 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117009493 Walker A/P-loop; other site 426117009494 ATP binding site [chemical binding]; other site 426117009495 Q-loop/lid; other site 426117009496 ABC transporter signature motif; other site 426117009497 Walker B; other site 426117009498 D-loop; other site 426117009499 H-loop/switch region; other site 426117009500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117009501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117009502 dimer interface [polypeptide binding]; other site 426117009503 conserved gate region; other site 426117009504 putative PBP binding loops; other site 426117009505 ABC-ATPase subunit interface; other site 426117009506 NMT1-like family; Region: NMT1_2; pfam13379 426117009507 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117009508 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426117009509 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426117009510 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426117009511 NAD binding site [chemical binding]; other site 426117009512 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 426117009513 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 426117009514 homotrimer interaction site [polypeptide binding]; other site 426117009515 putative active site [active] 426117009516 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 426117009517 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 426117009518 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 426117009519 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426117009520 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 426117009521 putative active site [active] 426117009522 metal binding site [ion binding]; metal-binding site 426117009523 PAS domain; Region: PAS; smart00091 426117009524 PAS fold; Region: PAS_7; pfam12860 426117009525 PAS fold; Region: PAS_7; pfam12860 426117009526 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117009527 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426117009528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117009529 dimer interface [polypeptide binding]; other site 426117009530 phosphorylation site [posttranslational modification] 426117009531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117009532 ATP binding site [chemical binding]; other site 426117009533 Mg2+ binding site [ion binding]; other site 426117009534 G-X-G motif; other site 426117009535 Response regulator receiver domain; Region: Response_reg; pfam00072 426117009536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009537 active site 426117009538 phosphorylation site [posttranslational modification] 426117009539 intermolecular recognition site; other site 426117009540 dimerization interface [polypeptide binding]; other site 426117009541 hypothetical protein; Provisional; Region: PRK06486 426117009542 intersubunit interface [polypeptide binding]; other site 426117009543 active site 426117009544 Zn2+ binding site [ion binding]; other site 426117009545 Replication initiator protein A; Region: RPA; pfam10134 426117009546 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 426117009547 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009548 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426117009549 Protein export membrane protein; Region: SecD_SecF; cl14618 426117009550 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 426117009551 dimerization interface [polypeptide binding]; other site 426117009552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117009553 dimer interface [polypeptide binding]; other site 426117009554 putative CheW interface [polypeptide binding]; other site 426117009555 Porin subfamily; Region: Porin_2; pfam02530 426117009556 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 426117009557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117009558 putative substrate translocation pore; other site 426117009559 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 426117009560 CoA binding domain; Region: CoA_binding_2; pfam13380 426117009561 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 426117009562 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 426117009563 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 426117009564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117009565 substrate binding site [chemical binding]; other site 426117009566 oxyanion hole (OAH) forming residues; other site 426117009567 trimer interface [polypeptide binding]; other site 426117009568 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117009569 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426117009570 NAD(P) binding site [chemical binding]; other site 426117009571 catalytic residues [active] 426117009572 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117009573 MarR family; Region: MarR; pfam01047 426117009574 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 426117009575 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 426117009576 putative active site pocket [active] 426117009577 metal binding site [ion binding]; metal-binding site 426117009578 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 426117009579 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426117009580 active site 426117009581 catalytic site [active] 426117009582 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426117009583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117009584 DNA-binding site [nucleotide binding]; DNA binding site 426117009585 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 426117009586 FCD domain; Region: FCD; pfam07729 426117009587 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426117009588 FAD binding domain; Region: FAD_binding_4; pfam01565 426117009589 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 426117009590 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 426117009591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117009592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117009593 catalytic residue [active] 426117009594 Hint domain; Region: Hint_2; pfam13403 426117009595 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 426117009596 Phage Tail Collar Domain; Region: Collar; pfam07484 426117009597 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 426117009598 Phage Tail Collar Domain; Region: Collar; pfam07484 426117009599 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426117009600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117009601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117009602 Coenzyme A binding pocket [chemical binding]; other site 426117009603 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 426117009604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117009605 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117009606 active site 426117009607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117009608 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 426117009609 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 426117009610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117009611 active site 426117009612 Predicted amidohydrolase [General function prediction only]; Region: COG0388 426117009613 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 426117009614 active site 426117009615 catalytic triad [active] 426117009616 dimer interface [polypeptide binding]; other site 426117009617 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117009618 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117009619 Walker A/P-loop; other site 426117009620 ATP binding site [chemical binding]; other site 426117009621 Q-loop/lid; other site 426117009622 ABC transporter signature motif; other site 426117009623 Walker B; other site 426117009624 D-loop; other site 426117009625 H-loop/switch region; other site 426117009626 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117009627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117009628 dimer interface [polypeptide binding]; other site 426117009629 conserved gate region; other site 426117009630 putative PBP binding loops; other site 426117009631 ABC-ATPase subunit interface; other site 426117009632 NMT1/THI5 like; Region: NMT1; pfam09084 426117009633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117009634 substrate binding pocket [chemical binding]; other site 426117009635 membrane-bound complex binding site; other site 426117009636 hinge residues; other site 426117009637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117009638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117009639 active site 426117009640 catalytic tetrad [active] 426117009641 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 426117009642 putative metal binding site [ion binding]; other site 426117009643 putative homodimer interface [polypeptide binding]; other site 426117009644 putative homotetramer interface [polypeptide binding]; other site 426117009645 putative homodimer-homodimer interface [polypeptide binding]; other site 426117009646 putative allosteric switch controlling residues; other site 426117009647 High-affinity nickel-transport protein; Region: NicO; cl00964 426117009648 High-affinity nickel-transport protein; Region: NicO; cl00964 426117009649 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117009650 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 426117009651 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 426117009652 DXD motif; other site 426117009653 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 426117009654 active site 426117009655 short chain dehydrogenase; Provisional; Region: PRK07041 426117009656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117009657 NAD(P) binding site [chemical binding]; other site 426117009658 active site 426117009659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117009660 NAD(P) binding site [chemical binding]; other site 426117009661 active site 426117009662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117009663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117009664 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117009665 putative effector binding pocket; other site 426117009666 dimerization interface [polypeptide binding]; other site 426117009667 Predicted membrane protein [Function unknown]; Region: COG2860 426117009668 UPF0126 domain; Region: UPF0126; pfam03458 426117009669 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117009670 Cytochrome P450; Region: p450; cl12078 426117009671 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426117009672 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426117009673 inhibitor site; inhibition site 426117009674 active site 426117009675 dimer interface [polypeptide binding]; other site 426117009676 catalytic residue [active] 426117009677 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117009678 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117009679 TM-ABC transporter signature motif; other site 426117009680 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117009681 TM-ABC transporter signature motif; other site 426117009682 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117009683 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117009684 putative ligand binding site [chemical binding]; other site 426117009685 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117009686 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 426117009687 Walker A/P-loop; other site 426117009688 ATP binding site [chemical binding]; other site 426117009689 Q-loop/lid; other site 426117009690 ABC transporter signature motif; other site 426117009691 Walker B; other site 426117009692 D-loop; other site 426117009693 H-loop/switch region; other site 426117009694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117009695 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117009696 Walker A/P-loop; other site 426117009697 ATP binding site [chemical binding]; other site 426117009698 Q-loop/lid; other site 426117009699 ABC transporter signature motif; other site 426117009700 Walker B; other site 426117009701 D-loop; other site 426117009702 H-loop/switch region; other site 426117009703 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117009704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117009705 DNA-binding site [nucleotide binding]; DNA binding site 426117009706 FCD domain; Region: FCD; pfam07729 426117009707 phosphogluconate dehydratase; Validated; Region: PRK09054 426117009708 6-phosphogluconate dehydratase; Region: edd; TIGR01196 426117009709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117009710 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 426117009711 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 426117009712 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 426117009713 lipoyl attachment site [posttranslational modification]; other site 426117009714 glycine dehydrogenase; Provisional; Region: PRK05367 426117009715 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117009716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117009717 catalytic residue [active] 426117009718 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 426117009719 tetramer interface [polypeptide binding]; other site 426117009720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117009721 catalytic residue [active] 426117009722 Nif-specific regulatory protein; Region: nifA; TIGR01817 426117009723 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426117009724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117009725 Walker A motif; other site 426117009726 ATP binding site [chemical binding]; other site 426117009727 Walker B motif; other site 426117009728 arginine finger; other site 426117009729 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117009730 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 426117009731 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 426117009732 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 426117009733 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 426117009734 dimer interface [polypeptide binding]; other site 426117009735 decamer (pentamer of dimers) interface [polypeptide binding]; other site 426117009736 catalytic triad [active] 426117009737 peroxidatic and resolving cysteines [active] 426117009738 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 426117009739 molybdenum transport protein ModD; Provisional; Region: PRK06096 426117009740 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 426117009741 active site 426117009742 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 426117009743 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 426117009744 Nucleotide-binding sites [chemical binding]; other site 426117009745 Walker A motif; other site 426117009746 Switch I region of nucleotide binding site; other site 426117009747 Fe4S4 binding sites [ion binding]; other site 426117009748 Switch II region of nucleotide binding site; other site 426117009749 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 426117009750 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 426117009751 MoFe protein alpha/beta subunit interactions; other site 426117009752 Alpha subunit P cluster binding residues; other site 426117009753 FeMoco binding residues [chemical binding]; other site 426117009754 MoFe protein alpha subunit/Fe protein contacts; other site 426117009755 MoFe protein dimer/ dimer interactions; other site 426117009756 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 426117009757 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 426117009758 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 426117009759 MoFe protein beta/alpha subunit interactions; other site 426117009760 Beta subunit P cluster binding residues; other site 426117009761 MoFe protein beta subunit/Fe protein contacts; other site 426117009762 MoFe protein dimer/ dimer interactions; other site 426117009763 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 426117009764 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 426117009765 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 426117009766 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 426117009767 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 426117009768 probable nitrogen fixation protein; Region: TIGR02935 426117009769 Rop-like; Region: Rop-like; pfam05082 426117009770 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 426117009771 NifQ; Region: NifQ; pfam04891 426117009772 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426117009773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117009774 classical (c) SDRs; Region: SDR_c; cd05233 426117009775 NAD(P) binding site [chemical binding]; other site 426117009776 active site 426117009777 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117009778 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426117009779 malic enzyme; Reviewed; Region: PRK12862 426117009780 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426117009781 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426117009782 putative NAD(P) binding site [chemical binding]; other site 426117009783 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 426117009784 hypothetical protein; Validated; Region: PRK06201 426117009785 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 426117009786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117009787 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117009788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426117009789 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426117009790 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426117009791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426117009792 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117009793 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426117009794 Response regulator receiver domain; Region: Response_reg; pfam00072 426117009795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009796 active site 426117009797 phosphorylation site [posttranslational modification] 426117009798 intermolecular recognition site; other site 426117009799 dimerization interface [polypeptide binding]; other site 426117009800 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 426117009801 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 426117009802 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 426117009803 active site 426117009804 catalytic site [active] 426117009805 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117009806 CHASE3 domain; Region: CHASE3; pfam05227 426117009807 PAS fold; Region: PAS_4; pfam08448 426117009808 PAS domain S-box; Region: sensory_box; TIGR00229 426117009809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117009810 putative active site [active] 426117009811 heme pocket [chemical binding]; other site 426117009812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117009813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117009814 dimer interface [polypeptide binding]; other site 426117009815 phosphorylation site [posttranslational modification] 426117009816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117009817 ATP binding site [chemical binding]; other site 426117009818 Mg2+ binding site [ion binding]; other site 426117009819 G-X-G motif; other site 426117009820 Response regulator receiver domain; Region: Response_reg; pfam00072 426117009821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009822 active site 426117009823 phosphorylation site [posttranslational modification] 426117009824 intermolecular recognition site; other site 426117009825 dimerization interface [polypeptide binding]; other site 426117009826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009827 Response regulator receiver domain; Region: Response_reg; pfam00072 426117009828 active site 426117009829 phosphorylation site [posttranslational modification] 426117009830 intermolecular recognition site; other site 426117009831 dimerization interface [polypeptide binding]; other site 426117009832 Dak1 domain; Region: Dak1; pfam02733 426117009833 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 426117009834 DAK2 domain; Region: Dak2; pfam02734 426117009835 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426117009836 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 426117009837 putative ligand binding site [chemical binding]; other site 426117009838 NAD binding site [chemical binding]; other site 426117009839 dimerization interface [polypeptide binding]; other site 426117009840 catalytic site [active] 426117009841 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 426117009842 MerR family regulatory protein; Region: MerR; pfam00376 426117009843 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117009844 P-loop; other site 426117009845 Magnesium ion binding site [ion binding]; other site 426117009846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117009847 Magnesium ion binding site [ion binding]; other site 426117009848 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 426117009849 ParB-like nuclease domain; Region: ParB; smart00470 426117009850 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 426117009851 dimer interface [polypeptide binding]; other site 426117009852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117009853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117009854 active site 426117009855 phosphorylation site [posttranslational modification] 426117009856 intermolecular recognition site; other site 426117009857 dimerization interface [polypeptide binding]; other site 426117009858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117009859 DNA binding site [nucleotide binding] 426117009860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117009861 dimer interface [polypeptide binding]; other site 426117009862 phosphorylation site [posttranslational modification] 426117009863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117009864 ATP binding site [chemical binding]; other site 426117009865 G-X-G motif; other site 426117009866 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426117009867 classical (c) SDRs; Region: SDR_c; cd05233 426117009868 NAD(P) binding site [chemical binding]; other site 426117009869 active site 426117009870 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426117009871 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426117009872 conserved cys residue [active] 426117009873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117009874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117009875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117009876 active site 426117009877 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426117009878 FOG: CBS domain [General function prediction only]; Region: COG0517 426117009879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 426117009880 BON domain; Region: BON; pfam04972 426117009881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117009882 Ligand Binding Site [chemical binding]; other site 426117009883 putative phosphoketolase; Provisional; Region: PRK05261 426117009884 XFP N-terminal domain; Region: XFP_N; pfam09364 426117009885 XFP C-terminal domain; Region: XFP_C; pfam09363 426117009886 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 426117009887 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 426117009888 oxidoreductase; Provisional; Region: PRK10015 426117009889 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 426117009890 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 426117009891 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 426117009892 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 426117009893 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 426117009894 Ligand binding site [chemical binding]; other site 426117009895 Electron transfer flavoprotein domain; Region: ETF; pfam01012 426117009896 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 426117009897 serine O-acetyltransferase; Region: cysE; TIGR01172 426117009898 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 426117009899 trimer interface [polypeptide binding]; other site 426117009900 active site 426117009901 substrate binding site [chemical binding]; other site 426117009902 CoA binding site [chemical binding]; other site 426117009903 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 426117009904 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 426117009905 active site 426117009906 catalytic residues [active] 426117009907 metal binding site [ion binding]; metal-binding site 426117009908 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 426117009909 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 426117009910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117009911 catalytic residue [active] 426117009912 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 426117009913 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 426117009914 trimerization site [polypeptide binding]; other site 426117009915 active site 426117009916 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426117009917 NifU-like domain; Region: NifU; pfam01106 426117009918 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 426117009919 V4R domain; Region: V4R; cl15268 426117009920 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 426117009921 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 426117009922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117009923 FeS/SAM binding site; other site 426117009924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117009925 sequence-specific DNA binding site [nucleotide binding]; other site 426117009926 salt bridge; other site 426117009927 Cupin domain; Region: Cupin_2; pfam07883 426117009928 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117009929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117009930 substrate binding pocket [chemical binding]; other site 426117009931 membrane-bound complex binding site; other site 426117009932 hinge residues; other site 426117009933 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117009934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117009935 dimer interface [polypeptide binding]; other site 426117009936 conserved gate region; other site 426117009937 putative PBP binding loops; other site 426117009938 ABC-ATPase subunit interface; other site 426117009939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117009940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117009941 Walker A/P-loop; other site 426117009942 ATP binding site [chemical binding]; other site 426117009943 Q-loop/lid; other site 426117009944 ABC transporter signature motif; other site 426117009945 Walker B; other site 426117009946 D-loop; other site 426117009947 H-loop/switch region; other site 426117009948 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426117009949 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 426117009950 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 426117009951 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 426117009952 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 426117009953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117009954 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 426117009955 FOG: CBS domain [General function prediction only]; Region: COG0517 426117009956 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 426117009957 BON domain; Region: BON; pfam04972 426117009958 SIR2-like domain; Region: SIR2_2; pfam13289 426117009959 NifT/FixU protein; Region: NifT; pfam06988 426117009960 NifZ domain; Region: NifZ; pfam04319 426117009961 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 426117009962 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426117009963 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 426117009964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117009965 FeS/SAM binding site; other site 426117009966 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 426117009967 cytosine deaminase; Provisional; Region: PRK05985 426117009968 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 426117009969 active site 426117009970 SnoaL-like domain; Region: SnoaL_2; pfam12680 426117009971 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117009972 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117009973 Walker A/P-loop; other site 426117009974 ATP binding site [chemical binding]; other site 426117009975 Q-loop/lid; other site 426117009976 ABC transporter signature motif; other site 426117009977 Walker B; other site 426117009978 D-loop; other site 426117009979 H-loop/switch region; other site 426117009980 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117009981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117009982 dimer interface [polypeptide binding]; other site 426117009983 conserved gate region; other site 426117009984 putative PBP binding loops; other site 426117009985 ABC-ATPase subunit interface; other site 426117009986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 426117009987 NMT1/THI5 like; Region: NMT1; pfam09084 426117009988 membrane-bound complex binding site; other site 426117009989 hinge residues; other site 426117009990 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 426117009991 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117009992 active site 426117009993 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117009994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117009995 DNA-binding site [nucleotide binding]; DNA binding site 426117009996 FCD domain; Region: FCD; pfam07729 426117009997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426117009998 EamA-like transporter family; Region: EamA; pfam00892 426117009999 EamA-like transporter family; Region: EamA; pfam00892 426117010000 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 426117010001 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 426117010002 metal binding site [ion binding]; metal-binding site 426117010003 dimer interface [polypeptide binding]; other site 426117010004 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117010005 cyclase homology domain; Region: CHD; cd07302 426117010006 nucleotidyl binding site; other site 426117010007 metal binding site [ion binding]; metal-binding site 426117010008 dimer interface [polypeptide binding]; other site 426117010009 hypothetical protein; Provisional; Region: PRK06847 426117010010 hypothetical protein; Provisional; Region: PRK07236 426117010011 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 426117010012 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117010013 NAD(P) binding site [chemical binding]; other site 426117010014 catalytic residues [active] 426117010015 FIST N domain; Region: FIST; pfam08495 426117010016 FIST C domain; Region: FIST_C; pfam10442 426117010017 ApbE family; Region: ApbE; pfam02424 426117010018 FMN-binding domain; Region: FMN_bind; cl01081 426117010019 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426117010020 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426117010021 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117010022 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117010023 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117010024 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426117010025 ligand binding site [chemical binding]; other site 426117010026 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426117010027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117010028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117010029 substrate binding pocket [chemical binding]; other site 426117010030 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426117010031 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 426117010032 dimer interface [polypeptide binding]; other site 426117010033 Trp docking motif [polypeptide binding]; other site 426117010034 active site 426117010035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117010036 GAF domain; Region: GAF; pfam01590 426117010037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010038 PAS fold; Region: PAS_3; pfam08447 426117010039 putative active site [active] 426117010040 heme pocket [chemical binding]; other site 426117010041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117010042 HWE histidine kinase; Region: HWE_HK; cl06527 426117010043 response regulator; Provisional; Region: PRK13435 426117010044 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 426117010045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117010046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117010047 substrate binding pocket [chemical binding]; other site 426117010048 membrane-bound complex binding site; other site 426117010049 hinge residues; other site 426117010050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010051 dimer interface [polypeptide binding]; other site 426117010052 conserved gate region; other site 426117010053 putative PBP binding loops; other site 426117010054 ABC-ATPase subunit interface; other site 426117010055 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117010056 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117010057 Walker A/P-loop; other site 426117010058 ATP binding site [chemical binding]; other site 426117010059 Q-loop/lid; other site 426117010060 ABC transporter signature motif; other site 426117010061 Walker B; other site 426117010062 D-loop; other site 426117010063 H-loop/switch region; other site 426117010064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117010065 active site 426117010066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117010067 active site 426117010068 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 426117010069 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 426117010070 metal binding site [ion binding]; metal-binding site 426117010071 substrate binding pocket [chemical binding]; other site 426117010072 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426117010073 hypothetical protein; Provisional; Region: PRK07538 426117010074 hypothetical protein; Provisional; Region: PRK07236 426117010075 Cupin domain; Region: Cupin_2; pfam07883 426117010076 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117010077 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117010078 Walker A/P-loop; other site 426117010079 ATP binding site [chemical binding]; other site 426117010080 Q-loop/lid; other site 426117010081 ABC transporter signature motif; other site 426117010082 Walker B; other site 426117010083 D-loop; other site 426117010084 H-loop/switch region; other site 426117010085 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117010086 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117010087 Walker A/P-loop; other site 426117010088 ATP binding site [chemical binding]; other site 426117010089 Q-loop/lid; other site 426117010090 ABC transporter signature motif; other site 426117010091 Walker B; other site 426117010092 D-loop; other site 426117010093 H-loop/switch region; other site 426117010094 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117010095 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117010096 TM-ABC transporter signature motif; other site 426117010097 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117010098 TM-ABC transporter signature motif; other site 426117010099 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117010100 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 426117010101 putative ligand binding site [chemical binding]; other site 426117010102 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117010103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117010104 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 426117010105 Cytochrome c; Region: Cytochrom_C; pfam00034 426117010106 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 426117010107 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426117010108 putative NAD(P) binding site [chemical binding]; other site 426117010109 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 426117010110 active site 426117010111 ATP binding site [chemical binding]; other site 426117010112 substrate binding site [chemical binding]; other site 426117010113 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 426117010114 dimer interface [polypeptide binding]; other site 426117010115 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 426117010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117010117 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117010118 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 426117010119 malate synthase G; Provisional; Region: PRK02999 426117010120 active site 426117010121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117010122 catalytic core [active] 426117010123 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426117010124 CoenzymeA binding site [chemical binding]; other site 426117010125 subunit interaction site [polypeptide binding]; other site 426117010126 PHB binding site; other site 426117010127 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 426117010128 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426117010129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117010130 FeS/SAM binding site; other site 426117010131 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 426117010132 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 426117010133 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 426117010134 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 426117010135 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 426117010136 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117010137 catalytic residues [active] 426117010138 central insert; other site 426117010139 heme exporter protein CcmC; Region: ccmC; TIGR01191 426117010140 heme exporter protein CcmB; Region: ccmB; TIGR01190 426117010141 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 426117010142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010143 Walker A/P-loop; other site 426117010144 ATP binding site [chemical binding]; other site 426117010145 Q-loop/lid; other site 426117010146 ABC transporter signature motif; other site 426117010147 Walker B; other site 426117010148 D-loop; other site 426117010149 H-loop/switch region; other site 426117010150 aconitate hydratase; Validated; Region: PRK09277 426117010151 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 426117010152 substrate binding site [chemical binding]; other site 426117010153 ligand binding site [chemical binding]; other site 426117010154 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 426117010155 substrate binding site [chemical binding]; other site 426117010156 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 426117010157 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 426117010158 Uncharacterized conserved protein [Function unknown]; Region: COG3287 426117010159 FIST N domain; Region: FIST; pfam08495 426117010160 FIST C domain; Region: FIST_C; pfam10442 426117010161 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426117010162 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 426117010163 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 426117010164 FMN binding site [chemical binding]; other site 426117010165 dimer interface [polypeptide binding]; other site 426117010166 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 426117010167 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 426117010168 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117010169 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 426117010170 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117010171 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 426117010172 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692 426117010173 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117010174 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117010175 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426117010176 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 426117010177 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 426117010178 flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789 426117010179 Flagellar P-ring protein; Region: FlgI; pfam02119 426117010180 Uncharacterized conserved protein [Function unknown]; Region: COG3334 426117010181 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 426117010182 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 426117010183 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 426117010184 RimM N-terminal domain; Region: RimM; pfam01782 426117010185 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 426117010186 signal recognition particle protein; Provisional; Region: PRK10867 426117010187 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 426117010188 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426117010189 P loop; other site 426117010190 GTP binding site [chemical binding]; other site 426117010191 Signal peptide binding domain; Region: SRP_SPB; pfam02978 426117010192 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 426117010193 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117010194 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117010195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117010196 NAD(P) binding site [chemical binding]; other site 426117010197 active site 426117010198 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 426117010199 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 426117010200 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 426117010201 Switch I; other site 426117010202 Switch II; other site 426117010203 septum formation inhibitor; Reviewed; Region: minC; PRK05177 426117010204 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 426117010205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117010206 ATP binding site [chemical binding]; other site 426117010207 putative Mg++ binding site [ion binding]; other site 426117010208 allophanate hydrolase; Provisional; Region: PRK08186 426117010209 Amidase; Region: Amidase; cl11426 426117010210 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 426117010211 phytoene desaturase; Region: crtI_fam; TIGR02734 426117010212 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426117010213 substrate binding pocket [chemical binding]; other site 426117010214 chain length determination region; other site 426117010215 substrate-Mg2+ binding site; other site 426117010216 catalytic residues [active] 426117010217 aspartate-rich region 1; other site 426117010218 active site lid residues [active] 426117010219 aspartate-rich region 2; other site 426117010220 O-methyltransferase; Region: Methyltransf_2; pfam00891 426117010221 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 426117010222 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117010223 NAD(P) binding site [chemical binding]; other site 426117010224 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117010225 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 426117010226 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 426117010227 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 426117010228 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 426117010229 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 426117010230 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 426117010231 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 426117010232 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 426117010233 subunit M interface; other site 426117010234 subunit H interface; other site 426117010235 quinone binding site; other site 426117010236 bacteriopheophytin binding site; other site 426117010237 bacteriochlorophyll binding site; other site 426117010238 cytochrome C subunit interface; other site 426117010239 Fe binding site [ion binding]; other site 426117010240 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 426117010241 subunit L interface; other site 426117010242 subunit H interface; other site 426117010243 bacteriopheophytin binding site; other site 426117010244 carotenoid binding site; other site 426117010245 bacteriochlorophyll binding site; other site 426117010246 cytochrome C interface; other site 426117010247 quinone binding site; other site 426117010248 Fe binding site [ion binding]; other site 426117010249 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 426117010250 subunit interface [polypeptide binding]; other site 426117010251 Heme binding sites [chemical binding]; other site 426117010252 Nitrate and nitrite sensing; Region: NIT; pfam08376 426117010253 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117010254 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426117010255 TspO/MBR family; Region: TspO_MBR; pfam03073 426117010256 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 426117010257 PUCC protein; Region: PUCC; pfam03209 426117010258 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 426117010259 UbiA prenyltransferase family; Region: UbiA; pfam01040 426117010260 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 426117010261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010262 putative active site [active] 426117010263 heme pocket [chemical binding]; other site 426117010264 PAS domain; Region: PAS; smart00091 426117010265 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117010266 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 426117010267 B12 binding site [chemical binding]; other site 426117010268 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 426117010269 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 426117010270 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 426117010271 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 426117010272 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 426117010273 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 426117010274 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 426117010275 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 426117010276 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 426117010277 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 426117010278 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117010279 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 426117010280 Methyltransferase domain; Region: Methyltransf_18; pfam12847 426117010281 S-adenosylmethionine binding site [chemical binding]; other site 426117010282 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 426117010283 PUCC protein; Region: PUCC; pfam03209 426117010284 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 426117010285 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 426117010286 subunit C interaction residues; other site 426117010287 subunit M interaction residues [polypeptide binding]; other site 426117010288 subunit L interaction residues [polypeptide binding]; other site 426117010289 putative proton transfer pathway, P1; other site 426117010290 putative proton transfer pathway, P2; other site 426117010291 Bacterial PH domain; Region: DUF304; pfam03703 426117010292 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 426117010293 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 426117010294 diiron binding motif [ion binding]; other site 426117010295 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 426117010296 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426117010297 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426117010298 substrate-cofactor binding pocket; other site 426117010299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117010300 catalytic residue [active] 426117010301 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 426117010302 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 426117010303 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426117010304 metal ion-dependent adhesion site (MIDAS); other site 426117010305 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 426117010306 phytoene desaturase; Region: crtI_fam; TIGR02734 426117010307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117010308 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426117010309 active site lid residues [active] 426117010310 substrate binding pocket [chemical binding]; other site 426117010311 catalytic residues [active] 426117010312 substrate-Mg2+ binding site; other site 426117010313 aspartate-rich region 1; other site 426117010314 aspartate-rich region 2; other site 426117010315 acetylornithine deacetylase; Provisional; Region: PRK06837 426117010316 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 426117010317 metal binding site [ion binding]; metal-binding site 426117010318 dimer interface [polypeptide binding]; other site 426117010319 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 426117010320 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426117010321 TPP-binding site [chemical binding]; other site 426117010322 dimer interface [polypeptide binding]; other site 426117010323 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426117010324 PYR/PP interface [polypeptide binding]; other site 426117010325 dimer interface [polypeptide binding]; other site 426117010326 TPP binding site [chemical binding]; other site 426117010327 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426117010328 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 426117010329 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 426117010330 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 426117010331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426117010332 active site 426117010333 phosphorylation site [posttranslational modification] 426117010334 intermolecular recognition site; other site 426117010335 dimerization interface [polypeptide binding]; other site 426117010336 ANTAR domain; Region: ANTAR; pfam03861 426117010337 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426117010338 NMT1-like family; Region: NMT1_2; pfam13379 426117010339 NMT1-like family; Region: NMT1_2; pfam13379 426117010340 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426117010341 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010343 dimer interface [polypeptide binding]; other site 426117010344 conserved gate region; other site 426117010345 putative PBP binding loops; other site 426117010346 ABC-ATPase subunit interface; other site 426117010347 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117010348 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117010349 Walker A/P-loop; other site 426117010350 ATP binding site [chemical binding]; other site 426117010351 Q-loop/lid; other site 426117010352 ABC transporter signature motif; other site 426117010353 Walker B; other site 426117010354 D-loop; other site 426117010355 H-loop/switch region; other site 426117010356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 426117010357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117010358 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 426117010359 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426117010360 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426117010361 sulfite reductase; Provisional; Region: PRK06214 426117010362 Putative Fe-S cluster; Region: FeS; cl17515 426117010363 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 426117010364 FAD binding pocket [chemical binding]; other site 426117010365 FAD binding motif [chemical binding]; other site 426117010366 catalytic residues [active] 426117010367 NAD binding pocket [chemical binding]; other site 426117010368 phosphate binding motif [ion binding]; other site 426117010369 beta-alpha-beta structure motif; other site 426117010370 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426117010371 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 426117010372 [4Fe-4S] binding site [ion binding]; other site 426117010373 molybdopterin cofactor binding site; other site 426117010374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 426117010375 molybdopterin cofactor binding site; other site 426117010376 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426117010377 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 426117010378 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 426117010379 homodimer interface [polypeptide binding]; other site 426117010380 active site 426117010381 SAM binding site [chemical binding]; other site 426117010382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117010383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117010384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117010385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117010386 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 426117010387 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 426117010388 putative active site [active] 426117010389 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117010390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010391 Walker A/P-loop; other site 426117010392 ATP binding site [chemical binding]; other site 426117010393 Q-loop/lid; other site 426117010394 ABC transporter signature motif; other site 426117010395 Walker B; other site 426117010396 D-loop; other site 426117010397 H-loop/switch region; other site 426117010398 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117010399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117010400 E3 interaction surface; other site 426117010401 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 426117010402 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 426117010403 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 426117010404 active site 2 [active] 426117010405 active site 1 [active] 426117010406 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 426117010407 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426117010408 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 426117010409 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 426117010410 ligand binding site [chemical binding]; other site 426117010411 NAD binding site [chemical binding]; other site 426117010412 tetramer interface [polypeptide binding]; other site 426117010413 catalytic site [active] 426117010414 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 426117010415 L-serine binding site [chemical binding]; other site 426117010416 ACT domain interface; other site 426117010417 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 426117010418 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 426117010419 Cu(I) binding site [ion binding]; other site 426117010420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117010421 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117010422 active site 426117010423 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117010424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117010425 substrate binding pocket [chemical binding]; other site 426117010426 membrane-bound complex binding site; other site 426117010427 hinge residues; other site 426117010428 glutathionine S-transferase; Provisional; Region: PRK10542 426117010429 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 426117010430 C-terminal domain interface [polypeptide binding]; other site 426117010431 GSH binding site (G-site) [chemical binding]; other site 426117010432 dimer interface [polypeptide binding]; other site 426117010433 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426117010434 substrate binding pocket (H-site) [chemical binding]; other site 426117010435 N-terminal domain interface [polypeptide binding]; other site 426117010436 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426117010437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117010438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117010439 catalytic residue [active] 426117010440 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426117010441 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 426117010442 OsmC-like protein; Region: OsmC; pfam02566 426117010443 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426117010444 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426117010445 active site 426117010446 catalytic triad [active] 426117010447 oxyanion hole [active] 426117010448 Transglycosylase; Region: Transgly; pfam00912 426117010449 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426117010450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426117010451 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 426117010452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117010453 Walker A motif; other site 426117010454 ATP binding site [chemical binding]; other site 426117010455 Walker B motif; other site 426117010456 arginine finger; other site 426117010457 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 426117010458 Domain of unknown function (DUF202); Region: DUF202; pfam02656 426117010459 Uncharacterized conserved protein [Function unknown]; Region: COG4850 426117010460 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 426117010461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 426117010462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117010463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117010464 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117010465 putative effector binding pocket; other site 426117010466 dimerization interface [polypeptide binding]; other site 426117010467 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 426117010468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117010469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117010470 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 426117010471 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 426117010472 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117010473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117010474 putative DNA binding site [nucleotide binding]; other site 426117010475 putative Zn2+ binding site [ion binding]; other site 426117010476 AsnC family; Region: AsnC_trans_reg; pfam01037 426117010477 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 426117010478 putative hydrophobic ligand binding site [chemical binding]; other site 426117010479 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 426117010480 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426117010481 Peptidase family M23; Region: Peptidase_M23; pfam01551 426117010482 Protein of unknown function DUF111; Region: DUF111; pfam01969 426117010483 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426117010484 Ligand Binding Site [chemical binding]; other site 426117010485 AIR carboxylase; Region: AIRC; cl00310 426117010486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117010487 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117010488 active site 426117010489 catalytic tetrad [active] 426117010490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117010491 S-adenosylmethionine binding site [chemical binding]; other site 426117010492 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117010493 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117010494 Integrase core domain; Region: rve; pfam00665 426117010495 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 426117010496 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426117010497 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 426117010498 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426117010499 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 426117010500 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 426117010501 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117010502 putative active site [active] 426117010503 putative metal binding site [ion binding]; other site 426117010504 aminotransferase; Provisional; Region: PRK06105 426117010505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117010506 inhibitor-cofactor binding pocket; inhibition site 426117010507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117010508 catalytic residue [active] 426117010509 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 426117010510 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 426117010511 putative ADP-binding pocket [chemical binding]; other site 426117010512 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117010513 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117010514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117010515 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117010516 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 426117010517 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 426117010518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117010519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010520 Walker A/P-loop; other site 426117010521 ATP binding site [chemical binding]; other site 426117010522 Q-loop/lid; other site 426117010523 ABC transporter signature motif; other site 426117010524 Walker B; other site 426117010525 D-loop; other site 426117010526 H-loop/switch region; other site 426117010527 aspartate aminotransferase; Provisional; Region: PRK05764 426117010528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117010529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117010530 homodimer interface [polypeptide binding]; other site 426117010531 catalytic residue [active] 426117010532 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426117010533 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117010534 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117010535 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117010536 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 426117010537 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426117010538 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426117010539 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 426117010540 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 426117010541 Walker A/P-loop; other site 426117010542 ATP binding site [chemical binding]; other site 426117010543 Q-loop/lid; other site 426117010544 ABC transporter signature motif; other site 426117010545 Walker B; other site 426117010546 D-loop; other site 426117010547 H-loop/switch region; other site 426117010548 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 426117010549 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 426117010550 DXD motif; other site 426117010551 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 426117010552 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117010553 acyltransferase NodA; Provisional; Region: PRK00756 426117010554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117010555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117010556 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 426117010557 putative substrate binding pocket [chemical binding]; other site 426117010558 putative dimerization interface [polypeptide binding]; other site 426117010559 Transposase domain (DUF772); Region: DUF772; pfam05598 426117010560 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 426117010561 Proline racemase; Region: Pro_racemase; pfam05544 426117010562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117010563 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 426117010564 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 426117010565 active site 426117010566 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117010567 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426117010568 ligand binding site [chemical binding]; other site 426117010569 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117010570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117010571 TM-ABC transporter signature motif; other site 426117010572 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117010573 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117010574 TM-ABC transporter signature motif; other site 426117010575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117010576 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117010577 Walker A/P-loop; other site 426117010578 ATP binding site [chemical binding]; other site 426117010579 Q-loop/lid; other site 426117010580 ABC transporter signature motif; other site 426117010581 Walker B; other site 426117010582 D-loop; other site 426117010583 H-loop/switch region; other site 426117010584 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117010585 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117010586 Walker A/P-loop; other site 426117010587 ATP binding site [chemical binding]; other site 426117010588 Q-loop/lid; other site 426117010589 ABC transporter signature motif; other site 426117010590 Walker B; other site 426117010591 D-loop; other site 426117010592 H-loop/switch region; other site 426117010593 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 426117010594 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426117010595 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426117010596 inhibitor site; inhibition site 426117010597 active site 426117010598 dimer interface [polypeptide binding]; other site 426117010599 catalytic residue [active] 426117010600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117010601 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 426117010602 tetramerization interface [polypeptide binding]; other site 426117010603 NAD(P) binding site [chemical binding]; other site 426117010604 catalytic residues [active] 426117010605 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426117010606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117010607 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117010608 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426117010609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117010610 DNA-binding site [nucleotide binding]; DNA binding site 426117010611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117010612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117010613 homodimer interface [polypeptide binding]; other site 426117010614 catalytic residue [active] 426117010615 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 426117010616 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 426117010617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117010618 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117010619 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117010620 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 426117010621 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117010622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010623 Walker A/P-loop; other site 426117010624 ATP binding site [chemical binding]; other site 426117010625 Q-loop/lid; other site 426117010626 ABC transporter signature motif; other site 426117010627 Walker B; other site 426117010628 D-loop; other site 426117010629 H-loop/switch region; other site 426117010630 TOBE domain; Region: TOBE_2; pfam08402 426117010631 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 426117010632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117010633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117010634 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117010635 acyl-activating enzyme (AAE) consensus motif; other site 426117010636 AMP binding site [chemical binding]; other site 426117010637 active site 426117010638 CoA binding site [chemical binding]; other site 426117010639 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117010640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010641 dimer interface [polypeptide binding]; other site 426117010642 conserved gate region; other site 426117010643 putative PBP binding loops; other site 426117010644 ABC-ATPase subunit interface; other site 426117010645 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 426117010646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010647 dimer interface [polypeptide binding]; other site 426117010648 conserved gate region; other site 426117010649 putative PBP binding loops; other site 426117010650 ABC-ATPase subunit interface; other site 426117010651 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426117010652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426117010653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117010654 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 426117010655 NAD(P) binding site [chemical binding]; other site 426117010656 catalytic residues [active] 426117010657 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 426117010658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117010659 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 426117010660 putative dimerization interface [polypeptide binding]; other site 426117010661 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 426117010662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426117010663 phosphate binding site [ion binding]; other site 426117010664 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426117010665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117010666 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117010667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010668 Walker A/P-loop; other site 426117010669 ATP binding site [chemical binding]; other site 426117010670 Q-loop/lid; other site 426117010671 ABC transporter signature motif; other site 426117010672 Walker B; other site 426117010673 D-loop; other site 426117010674 H-loop/switch region; other site 426117010675 TOBE domain; Region: TOBE_2; pfam08402 426117010676 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117010677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010678 dimer interface [polypeptide binding]; other site 426117010679 conserved gate region; other site 426117010680 putative PBP binding loops; other site 426117010681 ABC-ATPase subunit interface; other site 426117010682 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 426117010683 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426117010684 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117010685 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 426117010686 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 426117010687 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 426117010688 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 426117010689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117010690 non-specific DNA binding site [nucleotide binding]; other site 426117010691 salt bridge; other site 426117010692 sequence-specific DNA binding site [nucleotide binding]; other site 426117010693 Cupin domain; Region: Cupin_2; pfam07883 426117010694 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 426117010695 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117010696 inhibitor-cofactor binding pocket; inhibition site 426117010697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117010698 catalytic residue [active] 426117010699 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 426117010700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117010701 non-specific DNA binding site [nucleotide binding]; other site 426117010702 salt bridge; other site 426117010703 sequence-specific DNA binding site [nucleotide binding]; other site 426117010704 Cupin domain; Region: Cupin_2; pfam07883 426117010705 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 426117010706 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 426117010707 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 426117010708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117010709 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117010710 active site 426117010711 DNA binding site [nucleotide binding] 426117010712 Int/Topo IB signature motif; other site 426117010713 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426117010714 active site 426117010715 Int/Topo IB signature motif; other site 426117010716 catalytic residues [active] 426117010717 DNA binding site [nucleotide binding] 426117010718 Isochorismatase family; Region: Isochorismatase; pfam00857 426117010719 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 426117010720 catalytic triad [active] 426117010721 conserved cis-peptide bond; other site 426117010722 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 426117010723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 426117010724 Integrase core domain; Region: rve; pfam00665 426117010725 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117010726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117010727 Walker A motif; other site 426117010728 ATP binding site [chemical binding]; other site 426117010729 Walker B motif; other site 426117010730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117010731 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117010732 Integrase core domain; Region: rve; pfam00665 426117010733 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426117010734 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426117010735 phosphate binding site [ion binding]; other site 426117010736 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117010737 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117010738 putative ligand binding site [chemical binding]; other site 426117010739 hypothetical protein; Provisional; Region: PRK06208 426117010740 intersubunit interface [polypeptide binding]; other site 426117010741 active site 426117010742 Zn2+ binding site [ion binding]; other site 426117010743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117010744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117010745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117010746 dimerization interface [polypeptide binding]; other site 426117010747 Predicted small integral membrane protein [Function unknown]; Region: COG5605 426117010748 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 426117010749 Subunit I/III interface [polypeptide binding]; other site 426117010750 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 426117010751 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426117010752 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 426117010753 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 426117010754 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117010755 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 426117010756 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426117010757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426117010758 Integrase core domain; Region: rve_3; pfam13683 426117010759 PAS domain; Region: PAS; smart00091 426117010760 PAS fold; Region: PAS_7; pfam12860 426117010761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010762 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117010763 putative active site [active] 426117010764 heme pocket [chemical binding]; other site 426117010765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010766 putative active site [active] 426117010767 heme pocket [chemical binding]; other site 426117010768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010769 PAS fold; Region: PAS_3; pfam08447 426117010770 putative active site [active] 426117010771 heme pocket [chemical binding]; other site 426117010772 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117010773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117010774 metal binding site [ion binding]; metal-binding site 426117010775 active site 426117010776 I-site; other site 426117010777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117010778 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426117010779 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 426117010780 putative dimer interface [polypeptide binding]; other site 426117010781 hypothetical protein; Provisional; Region: PRK07236 426117010782 Protein of unknown function, DUF485; Region: DUF485; pfam04341 426117010783 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 426117010784 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 426117010785 Na binding site [ion binding]; other site 426117010786 Cupin domain; Region: Cupin_2; cl17218 426117010787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117010788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117010789 PAS fold; Region: PAS_4; pfam08448 426117010790 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117010791 GAF domain; Region: GAF; pfam01590 426117010792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117010793 GAF domain; Region: GAF; pfam01590 426117010794 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117010795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117010796 putative active site [active] 426117010797 heme pocket [chemical binding]; other site 426117010798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117010799 dimer interface [polypeptide binding]; other site 426117010800 phosphorylation site [posttranslational modification] 426117010801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117010802 ATP binding site [chemical binding]; other site 426117010803 Mg2+ binding site [ion binding]; other site 426117010804 G-X-G motif; other site 426117010805 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117010806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117010807 active site 426117010808 phosphorylation site [posttranslational modification] 426117010809 intermolecular recognition site; other site 426117010810 dimerization interface [polypeptide binding]; other site 426117010811 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426117010812 TadE-like protein; Region: TadE; pfam07811 426117010813 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 426117010814 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426117010815 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117010816 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426117010817 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117010818 Walker A/P-loop; other site 426117010819 ATP binding site [chemical binding]; other site 426117010820 Q-loop/lid; other site 426117010821 ABC transporter signature motif; other site 426117010822 Walker B; other site 426117010823 D-loop; other site 426117010824 H-loop/switch region; other site 426117010825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117010826 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426117010827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117010828 Walker A/P-loop; other site 426117010829 ATP binding site [chemical binding]; other site 426117010830 Q-loop/lid; other site 426117010831 ABC transporter signature motif; other site 426117010832 Walker B; other site 426117010833 D-loop; other site 426117010834 H-loop/switch region; other site 426117010835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117010836 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117010837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010838 dimer interface [polypeptide binding]; other site 426117010839 conserved gate region; other site 426117010840 putative PBP binding loops; other site 426117010841 ABC-ATPase subunit interface; other site 426117010842 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117010843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117010844 dimer interface [polypeptide binding]; other site 426117010845 conserved gate region; other site 426117010846 ABC-ATPase subunit interface; other site 426117010847 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117010848 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426117010849 dihydroorotase; Provisional; Region: PRK09237 426117010850 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117010851 active site 426117010852 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 426117010853 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 426117010854 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 426117010855 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 426117010856 active site 426117010857 Zn binding site [ion binding]; other site 426117010858 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 426117010859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117010860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 426117010861 Putative zinc-finger; Region: zf-HC2; pfam13490 426117010862 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117010863 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117010864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117010865 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117010866 active site 426117010867 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117010868 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426117010869 YGGT family; Region: YGGT; pfam02325 426117010870 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 426117010871 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 426117010872 putative active site [active] 426117010873 putative catalytic site [active] 426117010874 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 426117010875 putative active site [active] 426117010876 putative catalytic site [active] 426117010877 manganese transport regulator MntR; Provisional; Region: PRK11050 426117010878 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 426117010879 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 426117010880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426117010881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117010882 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 426117010883 Walker A/P-loop; other site 426117010884 ATP binding site [chemical binding]; other site 426117010885 Q-loop/lid; other site 426117010886 ABC transporter signature motif; other site 426117010887 Walker B; other site 426117010888 D-loop; other site 426117010889 H-loop/switch region; other site 426117010890 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426117010891 PBP superfamily domain; Region: PBP_like_2; pfam12849 426117010892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117010893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117010894 active site 426117010895 phosphorylation site [posttranslational modification] 426117010896 intermolecular recognition site; other site 426117010897 dimerization interface [polypeptide binding]; other site 426117010898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117010899 DNA binding site [nucleotide binding] 426117010900 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 426117010901 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117010902 Walker A motif; other site 426117010903 ATP binding site [chemical binding]; other site 426117010904 Walker B motif; other site 426117010905 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 426117010906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117010907 Coenzyme A binding pocket [chemical binding]; other site 426117010908 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117010909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117010910 Predicted integral membrane protein [Function unknown]; Region: COG0392 426117010911 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426117010912 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426117010913 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117010914 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117010915 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 426117010916 dimer interface [polypeptide binding]; other site 426117010917 active site 426117010918 coenzyme A binding site [chemical binding]; other site 426117010919 citrylCoA binding site [chemical binding]; other site 426117010920 oxalacetate/citrate binding site [chemical binding]; other site 426117010921 catalytic triad [active] 426117010922 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 426117010923 FHIPEP family; Region: FHIPEP; pfam00771 426117010924 Response regulator receiver domain; Region: Response_reg; pfam00072 426117010925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117010926 active site 426117010927 phosphorylation site [posttranslational modification] 426117010928 intermolecular recognition site; other site 426117010929 dimerization interface [polypeptide binding]; other site 426117010930 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 426117010931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117010932 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426117010933 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426117010934 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 426117010935 putative FMN binding site [chemical binding]; other site 426117010936 NADPH bind site [chemical binding]; other site 426117010937 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 426117010938 YcaO-like family; Region: YcaO; pfam02624 426117010939 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 426117010940 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117010941 AAA domain; Region: AAA_25; pfam13481 426117010942 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117010943 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 426117010944 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426117010945 active site 426117010946 Int/Topo IB signature motif; other site 426117010947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117010948 binding surface 426117010949 TPR motif; other site 426117010950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117010951 active site 426117010952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117010953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117010954 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117010955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117010956 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117010957 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238 426117010958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117010959 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117010960 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117010961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117010962 active site 426117010963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117010964 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117010965 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 426117010966 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117010967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117010968 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117010969 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117010970 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117010971 Integrase core domain; Region: rve; pfam00665 426117010972 Transposase; Region: HTH_Tnp_1; cl17663 426117010973 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426117010974 FAD binding domain; Region: FAD_binding_3; pfam01494 426117010975 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117010976 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117010977 Integrase core domain; Region: rve; pfam00665 426117010978 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 426117010979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117010980 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117010981 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117010982 Transposase domain (DUF772); Region: DUF772; pfam05598 426117010983 muropeptide transporter; Validated; Region: ampG; cl17669 426117010984 muropeptide transporter; Reviewed; Region: ampG; PRK11902 426117010985 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426117010986 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 426117010987 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 426117010988 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 426117010989 NADP-binding site; other site 426117010990 homotetramer interface [polypeptide binding]; other site 426117010991 substrate binding site [chemical binding]; other site 426117010992 homodimer interface [polypeptide binding]; other site 426117010993 active site 426117010994 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117010995 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 426117010996 NAD binding site [chemical binding]; other site 426117010997 putative substrate binding site 2 [chemical binding]; other site 426117010998 putative substrate binding site 1 [chemical binding]; other site 426117010999 active site 426117011000 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117011001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117011002 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117011003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117011004 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117011005 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117011006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117011007 active site 426117011008 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426117011009 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426117011010 Probable Catalytic site; other site 426117011011 metal-binding site 426117011012 O-Antigen ligase; Region: Wzy_C; cl04850 426117011013 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 426117011014 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 426117011015 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426117011016 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 426117011017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117011018 NAD(P) binding site [chemical binding]; other site 426117011019 active site 426117011020 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426117011021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117011022 active site 426117011023 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426117011024 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426117011025 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426117011026 inhibitor-cofactor binding pocket; inhibition site 426117011027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117011028 catalytic residue [active] 426117011029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117011030 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117011031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117011032 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426117011033 Probable Catalytic site; other site 426117011034 metal-binding site 426117011035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117011036 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117011037 ligand binding site [chemical binding]; other site 426117011038 flexible hinge region; other site 426117011039 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117011040 putative switch regulator; other site 426117011041 non-specific DNA interactions [nucleotide binding]; other site 426117011042 DNA binding site [nucleotide binding] 426117011043 sequence specific DNA binding site [nucleotide binding]; other site 426117011044 putative cAMP binding site [chemical binding]; other site 426117011045 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117011046 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117011047 ligand binding site [chemical binding]; other site 426117011048 flexible hinge region; other site 426117011049 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 426117011050 active site 426117011051 homotetramer interface [polypeptide binding]; other site 426117011052 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426117011053 Amidase; Region: Amidase; cl11426 426117011054 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117011055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117011056 Walker A/P-loop; other site 426117011057 ATP binding site [chemical binding]; other site 426117011058 Q-loop/lid; other site 426117011059 ABC transporter signature motif; other site 426117011060 Walker B; other site 426117011061 D-loop; other site 426117011062 H-loop/switch region; other site 426117011063 TOBE domain; Region: TOBE_2; pfam08402 426117011064 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426117011065 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426117011066 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 426117011067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117011068 dimer interface [polypeptide binding]; other site 426117011069 conserved gate region; other site 426117011070 putative PBP binding loops; other site 426117011071 ABC-ATPase subunit interface; other site 426117011072 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117011073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117011074 putative PBP binding loops; other site 426117011075 dimer interface [polypeptide binding]; other site 426117011076 ABC-ATPase subunit interface; other site 426117011077 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117011078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117011079 DNA-binding site [nucleotide binding]; DNA binding site 426117011080 FCD domain; Region: FCD; pfam07729 426117011081 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426117011082 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117011083 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117011084 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117011085 Uncharacterized conserved protein [Function unknown]; Region: COG0397 426117011086 hypothetical protein; Validated; Region: PRK00029 426117011087 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117011088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117011089 DNA-binding site [nucleotide binding]; DNA binding site 426117011090 FCD domain; Region: FCD; pfam07729 426117011091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011092 PAS domain; Region: PAS_9; pfam13426 426117011093 putative active site [active] 426117011094 heme pocket [chemical binding]; other site 426117011095 formyl-coenzyme A transferase; Provisional; Region: PRK05398 426117011096 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117011097 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 426117011098 HPP family; Region: HPP; pfam04982 426117011099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 426117011100 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 426117011101 Predicted esterase [General function prediction only]; Region: COG0400 426117011102 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 426117011103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117011104 PYR/PP interface [polypeptide binding]; other site 426117011105 dimer interface [polypeptide binding]; other site 426117011106 TPP binding site [chemical binding]; other site 426117011107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117011108 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 426117011109 TPP-binding site; other site 426117011110 dimer interface [polypeptide binding]; other site 426117011111 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 426117011112 SPFH domain / Band 7 family; Region: Band_7; pfam01145 426117011113 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 426117011114 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 426117011115 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117011116 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 426117011117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117011118 active site 426117011119 DNA binding site [nucleotide binding] 426117011120 Int/Topo IB signature motif; other site 426117011121 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 426117011122 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 426117011123 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 426117011124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117011125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117011126 salt bridge; other site 426117011127 non-specific DNA binding site [nucleotide binding]; other site 426117011128 sequence-specific DNA binding site [nucleotide binding]; other site 426117011129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117011130 non-specific DNA binding site [nucleotide binding]; other site 426117011131 salt bridge; other site 426117011132 sequence-specific DNA binding site [nucleotide binding]; other site 426117011133 RecT family; Region: RecT; cl04285 426117011134 exonuclease VIII; Reviewed; Region: PRK09709 426117011135 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 426117011136 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 426117011137 Catalytic site [active] 426117011138 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 426117011139 active site 426117011140 putative DNA-binding cleft [nucleotide binding]; other site 426117011141 dimer interface [polypeptide binding]; other site 426117011142 MT-A70; Region: MT-A70; cl01947 426117011143 replicative DNA helicase; Region: DnaB; TIGR00665 426117011144 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 426117011145 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117011146 Walker A motif; other site 426117011147 ATP binding site [chemical binding]; other site 426117011148 Walker B motif; other site 426117011149 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117011150 thymidylate kinase; Provisional; Region: PRK13975; cl17243 426117011151 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117011152 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 426117011153 catalytic residue [active] 426117011154 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 426117011155 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 426117011156 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 426117011157 Phage Tail Protein X; Region: Phage_tail_X; cl02088 426117011158 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 426117011159 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 426117011160 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 426117011161 Phage tail tube protein FII; Region: Phage_tube; cl01390 426117011162 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 426117011163 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 426117011164 Baseplate J-like protein; Region: Baseplate_J; cl01294 426117011165 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 426117011166 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 426117011167 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 426117011168 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 426117011169 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 426117011170 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 426117011171 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 426117011172 tandem repeat interface [polypeptide binding]; other site 426117011173 oligomer interface [polypeptide binding]; other site 426117011174 active site residues [active] 426117011175 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 426117011176 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 426117011177 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 426117011178 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 426117011179 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 426117011180 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 426117011181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117011182 Coenzyme A binding pocket [chemical binding]; other site 426117011183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 426117011184 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117011185 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117011186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117011187 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117011188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 426117011189 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426117011190 DNA binding site [nucleotide binding] 426117011191 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 426117011192 putative ligand binding site [chemical binding]; other site 426117011193 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117011194 MULE transposase domain; Region: MULE; pfam10551 426117011195 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117011196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117011197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117011198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426117011199 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117011200 catalytic residues [active] 426117011201 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 426117011202 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117011203 catalytic residues [active] 426117011204 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426117011205 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426117011206 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426117011207 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426117011208 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 426117011209 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426117011210 classical (c) SDRs; Region: SDR_c; cd05233 426117011211 NAD(P) binding site [chemical binding]; other site 426117011212 active site 426117011213 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 426117011214 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 426117011215 G1 box; other site 426117011216 putative GEF interaction site [polypeptide binding]; other site 426117011217 GTP/Mg2+ binding site [chemical binding]; other site 426117011218 Switch I region; other site 426117011219 G2 box; other site 426117011220 G3 box; other site 426117011221 Switch II region; other site 426117011222 G4 box; other site 426117011223 G5 box; other site 426117011224 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 426117011225 Response regulator receiver domain; Region: Response_reg; pfam00072 426117011226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117011227 active site 426117011228 phosphorylation site [posttranslational modification] 426117011229 intermolecular recognition site; other site 426117011230 dimerization interface [polypeptide binding]; other site 426117011231 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426117011232 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 426117011233 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117011234 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 426117011235 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117011236 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 426117011237 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117011238 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 426117011239 Rod binding protein; Region: Rod-binding; cl01626 426117011240 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 426117011241 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 426117011242 Class II flagellar assembly regulator; Region: FliX; pfam10768 426117011243 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 426117011244 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 426117011245 GcrA cell cycle regulator; Region: GcrA; cl11564 426117011246 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 426117011247 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 426117011248 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 426117011249 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426117011250 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 426117011251 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 426117011252 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117011253 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117011254 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 426117011255 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117011256 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 426117011257 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 426117011258 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 426117011259 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 426117011260 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 426117011261 Uncharacterized conserved protein [Function unknown]; Region: COG3334 426117011262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426117011263 dimerization interface [polypeptide binding]; other site 426117011264 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426117011265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117011266 dimer interface [polypeptide binding]; other site 426117011267 putative CheW interface [polypeptide binding]; other site 426117011268 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 426117011269 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 426117011270 active site 426117011271 interdomain interaction site; other site 426117011272 putative metal-binding site [ion binding]; other site 426117011273 nucleotide binding site [chemical binding]; other site 426117011274 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 426117011275 domain I; other site 426117011276 DNA binding groove [nucleotide binding] 426117011277 phosphate binding site [ion binding]; other site 426117011278 domain II; other site 426117011279 domain III; other site 426117011280 nucleotide binding site [chemical binding]; other site 426117011281 catalytic site [active] 426117011282 domain IV; other site 426117011283 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 426117011284 primary metal binding site; other site 426117011285 catalytic residues [active] 426117011286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117011287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117011288 metal binding site [ion binding]; metal-binding site 426117011289 active site 426117011290 I-site; other site 426117011291 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117011292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 426117011293 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 426117011294 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 426117011295 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 426117011296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426117011297 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117011298 GTPase CgtA; Reviewed; Region: obgE; PRK12299 426117011299 GTP1/OBG; Region: GTP1_OBG; pfam01018 426117011300 Obg GTPase; Region: Obg; cd01898 426117011301 G1 box; other site 426117011302 GTP/Mg2+ binding site [chemical binding]; other site 426117011303 Switch I region; other site 426117011304 G2 box; other site 426117011305 G3 box; other site 426117011306 Switch II region; other site 426117011307 G4 box; other site 426117011308 G5 box; other site 426117011309 Response regulator receiver domain; Region: Response_reg; pfam00072 426117011310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117011311 active site 426117011312 phosphorylation site [posttranslational modification] 426117011313 intermolecular recognition site; other site 426117011314 dimerization interface [polypeptide binding]; other site 426117011315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011316 PAS domain; Region: PAS_9; pfam13426 426117011317 putative active site [active] 426117011318 heme pocket [chemical binding]; other site 426117011319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011320 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117011321 putative active site [active] 426117011322 heme pocket [chemical binding]; other site 426117011323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011324 putative active site [active] 426117011325 heme pocket [chemical binding]; other site 426117011326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117011327 HWE histidine kinase; Region: HWE_HK; pfam07536 426117011328 gamma-glutamyl kinase; Provisional; Region: PRK05429 426117011329 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 426117011330 nucleotide binding site [chemical binding]; other site 426117011331 homotetrameric interface [polypeptide binding]; other site 426117011332 putative phosphate binding site [ion binding]; other site 426117011333 putative allosteric binding site; other site 426117011334 PUA domain; Region: PUA; pfam01472 426117011335 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 426117011336 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 426117011337 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 426117011338 putative catalytic cysteine [active] 426117011339 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 426117011340 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 426117011341 active site 426117011342 (T/H)XGH motif; other site 426117011343 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 426117011344 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 426117011345 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 426117011346 5' nucleotidase family; Region: 5_nucleotid; cl17687 426117011347 Peptidase family M23; Region: Peptidase_M23; pfam01551 426117011348 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 426117011349 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 426117011350 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 426117011351 protein binding site [polypeptide binding]; other site 426117011352 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 426117011353 Catalytic dyad [active] 426117011354 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 426117011355 NodB motif; other site 426117011356 putative active site [active] 426117011357 putative catalytic site [active] 426117011358 Zn binding site [ion binding]; other site 426117011359 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 426117011360 putative active site [active] 426117011361 Ap4A binding site [chemical binding]; other site 426117011362 nudix motif; other site 426117011363 putative metal binding site [ion binding]; other site 426117011364 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 426117011365 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 426117011366 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426117011367 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426117011368 putative dimer interface [polypeptide binding]; other site 426117011369 Uncharacterized small protein [Function unknown]; Region: COG5568 426117011370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117011371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117011372 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 426117011373 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 426117011374 putative ADP-binding pocket [chemical binding]; other site 426117011375 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 426117011376 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 426117011377 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 426117011378 AMP nucleosidase; Provisional; Region: PRK08292 426117011379 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 426117011380 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 426117011381 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 426117011382 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 426117011383 ATP binding site [chemical binding]; other site 426117011384 substrate interface [chemical binding]; other site 426117011385 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 426117011386 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 426117011387 metal binding site [ion binding]; metal-binding site 426117011388 dimer interface [polypeptide binding]; other site 426117011389 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117011390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117011391 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 426117011392 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 426117011393 dimerization interface 3.5A [polypeptide binding]; other site 426117011394 active site 426117011395 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 426117011396 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 426117011397 putative active site [active] 426117011398 substrate binding site [chemical binding]; other site 426117011399 putative cosubstrate binding site; other site 426117011400 catalytic site [active] 426117011401 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426117011402 substrate binding site [chemical binding]; other site 426117011403 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426117011404 active site 426117011405 catalytic residues [active] 426117011406 metal binding site [ion binding]; metal-binding site 426117011407 recombination protein RecR; Reviewed; Region: recR; PRK00076 426117011408 RecR protein; Region: RecR; pfam02132 426117011409 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 426117011410 putative active site [active] 426117011411 putative metal-binding site [ion binding]; other site 426117011412 tetramer interface [polypeptide binding]; other site 426117011413 hypothetical protein; Validated; Region: PRK00153 426117011414 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 426117011415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117011416 Walker A motif; other site 426117011417 ATP binding site [chemical binding]; other site 426117011418 Walker B motif; other site 426117011419 arginine finger; other site 426117011420 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 426117011421 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 426117011422 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117011423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117011424 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426117011425 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 426117011426 active site 426117011427 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 426117011428 AAA domain; Region: AAA_30; pfam13604 426117011429 Family description; Region: UvrD_C_2; pfam13538 426117011430 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 426117011431 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426117011432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426117011433 minor groove reading motif; other site 426117011434 helix-hairpin-helix signature motif; other site 426117011435 substrate binding pocket [chemical binding]; other site 426117011436 active site 426117011437 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 426117011438 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 426117011439 putative active site [active] 426117011440 putative metal binding site [ion binding]; other site 426117011441 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 426117011442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117011443 ATP binding site [chemical binding]; other site 426117011444 putative Mg++ binding site [ion binding]; other site 426117011445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117011446 nucleotide binding region [chemical binding]; other site 426117011447 ATP-binding site [chemical binding]; other site 426117011448 DEAD/H associated; Region: DEAD_assoc; pfam08494 426117011449 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 426117011450 ribonuclease PH; Reviewed; Region: rph; PRK00173 426117011451 Ribonuclease PH; Region: RNase_PH_bact; cd11362 426117011452 hexamer interface [polypeptide binding]; other site 426117011453 active site 426117011454 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 426117011455 active site 426117011456 dimerization interface [polypeptide binding]; other site 426117011457 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 426117011458 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117011459 MarR family; Region: MarR; pfam01047 426117011460 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426117011461 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 426117011462 FMN binding site [chemical binding]; other site 426117011463 active site 426117011464 substrate binding site [chemical binding]; other site 426117011465 catalytic residue [active] 426117011466 hypothetical protein; Provisional; Region: PRK09256 426117011467 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426117011468 Putative ParB-like nuclease; Region: ParBc_2; cl17538 426117011469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117011470 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117011471 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 426117011472 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 426117011473 tetramer interface [polypeptide binding]; other site 426117011474 active site 426117011475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117011476 Coenzyme A binding pocket [chemical binding]; other site 426117011477 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 426117011478 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 426117011479 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 426117011480 active site 426117011481 DNA binding site [nucleotide binding] 426117011482 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 426117011483 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426117011484 active site 426117011485 catalytic site [active] 426117011486 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 426117011487 catalytic triad [active] 426117011488 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 426117011489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117011490 Phasin protein; Region: Phasin_2; cl11491 426117011491 CsbD-like; Region: CsbD; pfam05532 426117011492 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426117011493 short chain dehydrogenase; Provisional; Region: PRK06181 426117011494 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426117011495 putative NAD(P) binding site [chemical binding]; other site 426117011496 active site 426117011497 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426117011498 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 426117011499 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 426117011500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 426117011501 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 426117011502 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 426117011503 IS2 transposase TnpB; Reviewed; Region: PRK09409 426117011504 HTH-like domain; Region: HTH_21; pfam13276 426117011505 Integrase core domain; Region: rve; pfam00665 426117011506 Integrase core domain; Region: rve_3; cl15866 426117011507 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117011508 Tetratricopeptide repeat; Region: TPR_1; pfam00515 426117011509 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117011510 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117011511 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 426117011512 putative N-terminal domain interface [polypeptide binding]; other site 426117011513 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 426117011514 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117011515 Cytochrome P450; Region: p450; cl12078 426117011516 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117011517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117011518 hypothetical protein; Provisional; Region: PRK08317 426117011519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117011520 S-adenosylmethionine binding site [chemical binding]; other site 426117011521 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117011522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117011523 putative substrate translocation pore; other site 426117011524 Maf-like protein; Region: Maf; pfam02545 426117011525 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 426117011526 active site 426117011527 dimer interface [polypeptide binding]; other site 426117011528 Domain of unknown function (DUF329); Region: DUF329; cl01144 426117011529 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117011530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117011531 active site 426117011532 metal binding site [ion binding]; metal-binding site 426117011533 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 426117011534 Recombination protein O N terminal; Region: RecO_N; pfam11967 426117011535 Recombination protein O C terminal; Region: RecO_C; pfam02565 426117011536 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 426117011537 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426117011538 CAP-like domain; other site 426117011539 active site 426117011540 primary dimer interface [polypeptide binding]; other site 426117011541 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 426117011542 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 426117011543 acyl-activating enzyme (AAE) consensus motif; other site 426117011544 putative AMP binding site [chemical binding]; other site 426117011545 putative active site [active] 426117011546 putative CoA binding site [chemical binding]; other site 426117011547 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 426117011548 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426117011549 homodimer interface [polypeptide binding]; other site 426117011550 substrate-cofactor binding pocket; other site 426117011551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117011552 catalytic residue [active] 426117011553 homoserine O-succinyltransferase; Provisional; Region: PRK05368 426117011554 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 426117011555 conserved cys residue [active] 426117011556 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426117011557 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 426117011558 NAD(P) binding site [chemical binding]; other site 426117011559 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426117011560 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426117011561 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 426117011562 Predicted transcriptional regulators [Transcription]; Region: COG1510 426117011563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117011564 dimerization interface [polypeptide binding]; other site 426117011565 putative DNA binding site [nucleotide binding]; other site 426117011566 putative Zn2+ binding site [ion binding]; other site 426117011567 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 426117011568 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 426117011569 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 426117011570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117011571 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 426117011572 Walker A/P-loop; other site 426117011573 ATP binding site [chemical binding]; other site 426117011574 Q-loop/lid; other site 426117011575 ABC transporter signature motif; other site 426117011576 Walker B; other site 426117011577 D-loop; other site 426117011578 H-loop/switch region; other site 426117011579 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 426117011580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117011581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117011582 metal binding site [ion binding]; metal-binding site 426117011583 active site 426117011584 I-site; other site 426117011585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426117011586 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426117011587 ATP binding site [chemical binding]; other site 426117011588 Mg++ binding site [ion binding]; other site 426117011589 motif III; other site 426117011590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117011591 nucleotide binding region [chemical binding]; other site 426117011592 ATP-binding site [chemical binding]; other site 426117011593 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426117011594 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 426117011595 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 426117011596 GatB domain; Region: GatB_Yqey; smart00845 426117011597 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426117011598 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 426117011599 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 426117011600 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 426117011601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117011602 dimer interface [polypeptide binding]; other site 426117011603 conserved gate region; other site 426117011604 putative PBP binding loops; other site 426117011605 ABC-ATPase subunit interface; other site 426117011606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117011607 dimer interface [polypeptide binding]; other site 426117011608 conserved gate region; other site 426117011609 putative PBP binding loops; other site 426117011610 ABC-ATPase subunit interface; other site 426117011611 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117011612 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117011613 Walker A/P-loop; other site 426117011614 ATP binding site [chemical binding]; other site 426117011615 Q-loop/lid; other site 426117011616 ABC transporter signature motif; other site 426117011617 Walker B; other site 426117011618 D-loop; other site 426117011619 H-loop/switch region; other site 426117011620 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 426117011621 metal-dependent hydrolase; Provisional; Region: PRK00685 426117011622 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 426117011623 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 426117011624 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 426117011625 DNA protecting protein DprA; Region: dprA; TIGR00732 426117011626 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 426117011627 dihydroorotase; Validated; Region: PRK09059 426117011628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117011629 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 426117011630 active site 426117011631 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 426117011632 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426117011633 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426117011634 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 426117011635 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 426117011636 active site 426117011637 interdomain interaction site; other site 426117011638 putative metal-binding site [ion binding]; other site 426117011639 nucleotide binding site [chemical binding]; other site 426117011640 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 426117011641 domain I; other site 426117011642 DNA binding groove [nucleotide binding] 426117011643 phosphate binding site [ion binding]; other site 426117011644 domain II; other site 426117011645 domain III; other site 426117011646 nucleotide binding site [chemical binding]; other site 426117011647 catalytic site [active] 426117011648 domain IV; other site 426117011649 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 426117011650 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426117011651 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426117011652 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426117011653 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 426117011654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117011655 Mg2+ binding site [ion binding]; other site 426117011656 G-X-G motif; other site 426117011657 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426117011658 anchoring element; other site 426117011659 dimer interface [polypeptide binding]; other site 426117011660 ATP binding site [chemical binding]; other site 426117011661 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 426117011662 active site 426117011663 putative metal-binding site [ion binding]; other site 426117011664 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426117011665 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 426117011666 catalytic Zn binding site [ion binding]; other site 426117011667 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 426117011668 structural Zn binding site [ion binding]; other site 426117011669 tetramer interface [polypeptide binding]; other site 426117011670 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426117011671 PAS fold; Region: PAS_3; pfam08447 426117011672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011673 putative active site [active] 426117011674 heme pocket [chemical binding]; other site 426117011675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117011676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117011677 dimer interface [polypeptide binding]; other site 426117011678 putative CheW interface [polypeptide binding]; other site 426117011679 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 426117011680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117011681 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426117011682 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 426117011683 C-terminal domain interface [polypeptide binding]; other site 426117011684 GSH binding site (G-site) [chemical binding]; other site 426117011685 dimer interface [polypeptide binding]; other site 426117011686 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 426117011687 N-terminal domain interface [polypeptide binding]; other site 426117011688 putative dimer interface [polypeptide binding]; other site 426117011689 active site 426117011690 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426117011691 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 426117011692 active site 426117011693 multimer interface [polypeptide binding]; other site 426117011694 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426117011695 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 426117011696 putative [4Fe-4S] binding site [ion binding]; other site 426117011697 putative molybdopterin cofactor binding site [chemical binding]; other site 426117011698 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 426117011699 molybdopterin cofactor binding site; other site 426117011700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117011701 dimerization interface [polypeptide binding]; other site 426117011702 putative DNA binding site [nucleotide binding]; other site 426117011703 putative Zn2+ binding site [ion binding]; other site 426117011704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117011705 S-adenosylmethionine binding site [chemical binding]; other site 426117011706 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 426117011707 FAD binding site [chemical binding]; other site 426117011708 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 426117011709 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 426117011710 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 426117011711 substrate binding pocket [chemical binding]; other site 426117011712 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 426117011713 B12 binding site [chemical binding]; other site 426117011714 cobalt ligand [ion binding]; other site 426117011715 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 426117011716 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 426117011717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117011718 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 426117011719 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 426117011720 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 426117011721 homodimer interface [polypeptide binding]; other site 426117011722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117011723 catalytic residue [active] 426117011724 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 426117011725 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 426117011726 amidase catalytic site [active] 426117011727 Zn binding residues [ion binding]; other site 426117011728 substrate binding site [chemical binding]; other site 426117011729 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117011730 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 426117011731 putative metal binding site [ion binding]; other site 426117011732 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 426117011733 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426117011734 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426117011735 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 426117011736 dimer interface [polypeptide binding]; other site 426117011737 catalytic residues [active] 426117011738 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 426117011739 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 426117011740 FMN binding site [chemical binding]; other site 426117011741 active site 426117011742 catalytic residues [active] 426117011743 substrate binding site [chemical binding]; other site 426117011744 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 426117011745 catalytic motif [active] 426117011746 Catalytic residue [active] 426117011747 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 426117011748 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 426117011749 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 426117011750 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 426117011751 putative dimer interface [polypeptide binding]; other site 426117011752 active site pocket [active] 426117011753 putative cataytic base [active] 426117011754 H+ Antiporter protein; Region: 2A0121; TIGR00900 426117011755 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426117011756 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426117011757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117011758 dimer interface [polypeptide binding]; other site 426117011759 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117011760 putative CheW interface [polypeptide binding]; other site 426117011761 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426117011762 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 426117011763 NADH dehydrogenase subunit B; Validated; Region: PRK06411 426117011764 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 426117011765 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 426117011766 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 426117011767 NADH dehydrogenase subunit D; Validated; Region: PRK06075 426117011768 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 426117011769 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 426117011770 putative dimer interface [polypeptide binding]; other site 426117011771 [2Fe-2S] cluster binding site [ion binding]; other site 426117011772 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 426117011773 SLBB domain; Region: SLBB; pfam10531 426117011774 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 426117011775 NADH dehydrogenase subunit G; Validated; Region: PRK09130 426117011776 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117011777 catalytic loop [active] 426117011778 iron binding site [ion binding]; other site 426117011779 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 426117011780 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 426117011781 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 426117011782 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 426117011783 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 426117011784 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 426117011785 4Fe-4S binding domain; Region: Fer4; pfam00037 426117011786 4Fe-4S binding domain; Region: Fer4; pfam00037 426117011787 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 426117011788 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 426117011789 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 426117011790 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 426117011791 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 426117011792 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 426117011793 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426117011794 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 426117011795 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426117011796 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 426117011797 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426117011798 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 426117011799 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 426117011800 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 426117011801 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 426117011802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117011803 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 426117011804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117011805 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 426117011806 dimer interface [polypeptide binding]; other site 426117011807 substrate binding site [chemical binding]; other site 426117011808 metal binding site [ion binding]; metal-binding site 426117011809 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 426117011810 prolyl-tRNA synthetase; Provisional; Region: PRK12325 426117011811 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 426117011812 dimer interface [polypeptide binding]; other site 426117011813 motif 1; other site 426117011814 active site 426117011815 motif 2; other site 426117011816 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426117011817 active site 426117011818 motif 3; other site 426117011819 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 426117011820 anticodon binding site; other site 426117011821 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 426117011822 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426117011823 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117011824 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117011825 Walker A/P-loop; other site 426117011826 ATP binding site [chemical binding]; other site 426117011827 Q-loop/lid; other site 426117011828 ABC transporter signature motif; other site 426117011829 Walker B; other site 426117011830 D-loop; other site 426117011831 H-loop/switch region; other site 426117011832 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 426117011833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117011834 dimer interface [polypeptide binding]; other site 426117011835 conserved gate region; other site 426117011836 ABC-ATPase subunit interface; other site 426117011837 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 426117011838 hypothetical protein; Provisional; Region: PRK08912 426117011839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117011840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117011841 homodimer interface [polypeptide binding]; other site 426117011842 catalytic residue [active] 426117011843 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117011844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117011845 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 426117011846 Protein export membrane protein; Region: SecD_SecF; cl14618 426117011847 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 426117011848 Protein export membrane protein; Region: SecD_SecF; cl14618 426117011849 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 426117011850 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117011851 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 426117011852 Restriction endonuclease; Region: Mrr_cat; pfam04471 426117011853 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 426117011854 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117011855 cyclase homology domain; Region: CHD; cd07302 426117011856 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117011857 nucleotidyl binding site; other site 426117011858 metal binding site [ion binding]; metal-binding site 426117011859 dimer interface [polypeptide binding]; other site 426117011860 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 426117011861 Ca2+ binding site [ion binding]; other site 426117011862 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 426117011863 Domain of unknown function DUF21; Region: DUF21; pfam01595 426117011864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426117011865 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 426117011866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117011867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117011868 metal binding site [ion binding]; metal-binding site 426117011869 active site 426117011870 I-site; other site 426117011871 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117011872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117011873 metal binding site [ion binding]; metal-binding site 426117011874 active site 426117011875 I-site; other site 426117011876 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 426117011877 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 426117011878 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 426117011879 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 426117011880 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 426117011881 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117011882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117011883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117011884 ATP binding site [chemical binding]; other site 426117011885 Mg2+ binding site [ion binding]; other site 426117011886 G-X-G motif; other site 426117011887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117011888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117011889 active site 426117011890 phosphorylation site [posttranslational modification] 426117011891 intermolecular recognition site; other site 426117011892 dimerization interface [polypeptide binding]; other site 426117011893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117011894 DNA binding site [nucleotide binding] 426117011895 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426117011896 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426117011897 active site 426117011898 substrate binding sites [chemical binding]; other site 426117011899 PAS domain S-box; Region: sensory_box; TIGR00229 426117011900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117011901 putative active site [active] 426117011902 heme pocket [chemical binding]; other site 426117011903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117011904 Histidine kinase; Region: HisKA_2; pfam07568 426117011905 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 426117011906 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 426117011907 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117011908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117011909 dimerization interface [polypeptide binding]; other site 426117011910 putative DNA binding site [nucleotide binding]; other site 426117011911 putative Zn2+ binding site [ion binding]; other site 426117011912 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 426117011913 DNA gyrase subunit A; Validated; Region: PRK05560 426117011914 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426117011915 CAP-like domain; other site 426117011916 active site 426117011917 primary dimer interface [polypeptide binding]; other site 426117011918 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426117011919 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426117011920 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426117011921 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426117011922 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426117011923 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426117011924 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426117011925 dimer interface [polypeptide binding]; other site 426117011926 ssDNA binding site [nucleotide binding]; other site 426117011927 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426117011928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117011929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117011930 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117011931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117011932 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117011933 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117011934 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117011935 catalytic residue [active] 426117011936 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 426117011937 Prostaglandin dehydrogenases; Region: PGDH; cd05288 426117011938 NAD(P) binding site [chemical binding]; other site 426117011939 substrate binding site [chemical binding]; other site 426117011940 dimer interface [polypeptide binding]; other site 426117011941 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 426117011942 Predicted periplasmic protein [Function unknown]; Region: COG3698 426117011943 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 426117011944 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 426117011945 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 426117011946 active site 426117011947 (T/H)XGH motif; other site 426117011948 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 426117011949 active site 426117011950 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 426117011951 active site 426117011952 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 426117011953 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 426117011954 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426117011955 catalytic residues [active] 426117011956 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 426117011957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117011958 Walker A/P-loop; other site 426117011959 ATP binding site [chemical binding]; other site 426117011960 Q-loop/lid; other site 426117011961 ABC transporter signature motif; other site 426117011962 Walker B; other site 426117011963 D-loop; other site 426117011964 H-loop/switch region; other site 426117011965 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426117011966 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426117011967 dimer interface [polypeptide binding]; other site 426117011968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117011969 catalytic residue [active] 426117011970 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426117011971 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 426117011972 Moco binding site; other site 426117011973 metal coordination site [ion binding]; other site 426117011974 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 426117011975 FAD binding pocket [chemical binding]; other site 426117011976 conserved FAD binding motif [chemical binding]; other site 426117011977 phosphate binding motif [ion binding]; other site 426117011978 beta-alpha-beta structure motif; other site 426117011979 NAD binding pocket [chemical binding]; other site 426117011980 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426117011981 FAD binding domain; Region: FAD_binding_4; pfam01565 426117011982 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 426117011983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117011984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117011985 DNA binding residues [nucleotide binding] 426117011986 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 426117011987 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 426117011988 active site 426117011989 NTP binding site [chemical binding]; other site 426117011990 metal binding triad [ion binding]; metal-binding site 426117011991 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 426117011992 putative active site [active] 426117011993 putative CoA binding site [chemical binding]; other site 426117011994 nudix motif; other site 426117011995 metal binding site [ion binding]; metal-binding site 426117011996 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 426117011997 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426117011998 CoenzymeA binding site [chemical binding]; other site 426117011999 subunit interaction site [polypeptide binding]; other site 426117012000 PHB binding site; other site 426117012001 MoxR-like ATPases [General function prediction only]; Region: COG0714 426117012002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426117012003 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 426117012004 Protein of unknown function DUF58; Region: DUF58; pfam01882 426117012005 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 426117012006 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 426117012007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117012008 Coenzyme A binding pocket [chemical binding]; other site 426117012009 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 426117012010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117012011 substrate binding pocket [chemical binding]; other site 426117012012 membrane-bound complex binding site; other site 426117012013 hinge residues; other site 426117012014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117012015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012016 dimer interface [polypeptide binding]; other site 426117012017 conserved gate region; other site 426117012018 putative PBP binding loops; other site 426117012019 ABC-ATPase subunit interface; other site 426117012020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012021 dimer interface [polypeptide binding]; other site 426117012022 conserved gate region; other site 426117012023 putative PBP binding loops; other site 426117012024 ABC-ATPase subunit interface; other site 426117012025 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117012026 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 426117012027 Walker A/P-loop; other site 426117012028 ATP binding site [chemical binding]; other site 426117012029 Q-loop/lid; other site 426117012030 ABC transporter signature motif; other site 426117012031 Walker B; other site 426117012032 D-loop; other site 426117012033 H-loop/switch region; other site 426117012034 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426117012035 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 426117012036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012037 dimer interface [polypeptide binding]; other site 426117012038 conserved gate region; other site 426117012039 ABC-ATPase subunit interface; other site 426117012040 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 426117012041 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 426117012042 Walker A/P-loop; other site 426117012043 ATP binding site [chemical binding]; other site 426117012044 Q-loop/lid; other site 426117012045 ABC transporter signature motif; other site 426117012046 Walker B; other site 426117012047 D-loop; other site 426117012048 H-loop/switch region; other site 426117012049 NIL domain; Region: NIL; pfam09383 426117012050 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 426117012051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117012052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117012053 metal binding site [ion binding]; metal-binding site 426117012054 active site 426117012055 I-site; other site 426117012056 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 426117012057 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426117012058 NAD binding site [chemical binding]; other site 426117012059 catalytic Zn binding site [ion binding]; other site 426117012060 structural Zn binding site [ion binding]; other site 426117012061 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 426117012062 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 426117012063 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 426117012064 putative active site [active] 426117012065 putative PHP Thumb interface [polypeptide binding]; other site 426117012066 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 426117012067 generic binding surface II; other site 426117012068 generic binding surface I; other site 426117012069 DNA Polymerase Y-family; Region: PolY_like; cd03468 426117012070 DNA binding site [nucleotide binding] 426117012071 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 426117012072 Uncharacterized conserved protein [Function unknown]; Region: COG4544 426117012073 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117012074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117012075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117012076 DNA binding residues [nucleotide binding] 426117012077 CsbD-like; Region: CsbD; pfam05532 426117012078 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 426117012079 Protein export membrane protein; Region: SecD_SecF; cl14618 426117012080 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117012081 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117012082 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117012083 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117012084 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 426117012085 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117012086 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117012087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117012088 NMT1/THI5 like; Region: NMT1; pfam09084 426117012089 substrate binding pocket [chemical binding]; other site 426117012090 membrane-bound complex binding site; other site 426117012091 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117012092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012093 putative PBP binding loops; other site 426117012094 ABC-ATPase subunit interface; other site 426117012095 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117012096 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117012097 Walker A/P-loop; other site 426117012098 ATP binding site [chemical binding]; other site 426117012099 Q-loop/lid; other site 426117012100 ABC transporter signature motif; other site 426117012101 Walker B; other site 426117012102 D-loop; other site 426117012103 H-loop/switch region; other site 426117012104 excinuclease ABC subunit B; Provisional; Region: PRK05298 426117012105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117012106 ATP binding site [chemical binding]; other site 426117012107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117012108 nucleotide binding region [chemical binding]; other site 426117012109 ATP-binding site [chemical binding]; other site 426117012110 Ultra-violet resistance protein B; Region: UvrB; pfam12344 426117012111 transcriptional regulator; Provisional; Region: PRK10632 426117012112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117012113 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117012114 putative effector binding pocket; other site 426117012115 dimerization interface [polypeptide binding]; other site 426117012116 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 426117012117 putative metal binding site [ion binding]; other site 426117012118 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 426117012119 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117012120 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117012121 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117012122 catalytic residue [active] 426117012123 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 426117012124 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117012125 Walker A/P-loop; other site 426117012126 ATP binding site [chemical binding]; other site 426117012127 Q-loop/lid; other site 426117012128 ABC transporter signature motif; other site 426117012129 Walker B; other site 426117012130 D-loop; other site 426117012131 H-loop/switch region; other site 426117012132 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117012133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117012134 Walker A/P-loop; other site 426117012135 ATP binding site [chemical binding]; other site 426117012136 Q-loop/lid; other site 426117012137 ABC transporter signature motif; other site 426117012138 Walker B; other site 426117012139 D-loop; other site 426117012140 H-loop/switch region; other site 426117012141 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 426117012142 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 426117012143 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117012144 Cytochrome P450; Region: p450; cl12078 426117012145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117012146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117012147 WHG domain; Region: WHG; pfam13305 426117012148 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 426117012149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426117012150 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117012151 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 426117012152 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 426117012153 catalytic site [active] 426117012154 putative active site [active] 426117012155 putative substrate binding site [chemical binding]; other site 426117012156 HRDC domain; Region: HRDC; pfam00570 426117012157 PilZ domain; Region: PilZ; pfam07238 426117012158 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 426117012159 PilZ domain; Region: PilZ; pfam07238 426117012160 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 426117012161 Cupin domain; Region: Cupin_2; pfam07883 426117012162 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 426117012163 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426117012164 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 426117012165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426117012166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117012167 UGMP family protein; Validated; Region: PRK09604 426117012168 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 426117012169 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 426117012170 EthD domain; Region: EthD; cl17553 426117012171 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426117012172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117012173 Protein of unknown function (DUF938); Region: DUF938; pfam06080 426117012174 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 426117012175 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 426117012176 active site 426117012177 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 426117012178 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 426117012179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117012180 substrate binding pocket [chemical binding]; other site 426117012181 membrane-bound complex binding site; other site 426117012182 hinge residues; other site 426117012183 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117012184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012185 dimer interface [polypeptide binding]; other site 426117012186 conserved gate region; other site 426117012187 putative PBP binding loops; other site 426117012188 ABC-ATPase subunit interface; other site 426117012189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012190 dimer interface [polypeptide binding]; other site 426117012191 conserved gate region; other site 426117012192 putative PBP binding loops; other site 426117012193 ABC-ATPase subunit interface; other site 426117012194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117012195 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117012196 Walker A/P-loop; other site 426117012197 ATP binding site [chemical binding]; other site 426117012198 Q-loop/lid; other site 426117012199 ABC transporter signature motif; other site 426117012200 Walker B; other site 426117012201 D-loop; other site 426117012202 H-loop/switch region; other site 426117012203 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 426117012204 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 426117012205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117012206 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 426117012207 putative dimerization interface [polypeptide binding]; other site 426117012208 Predicted membrane protein [Function unknown]; Region: COG2855 426117012209 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 426117012210 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 426117012211 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 426117012212 RNA polymerase sigma factor; Provisional; Region: PRK12511 426117012213 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117012214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117012215 DNA binding residues [nucleotide binding] 426117012216 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426117012217 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426117012218 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 426117012219 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 426117012220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117012221 FeS/SAM binding site; other site 426117012222 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 426117012223 putative active site [active] 426117012224 putative substrate binding site [chemical binding]; other site 426117012225 ATP binding site [chemical binding]; other site 426117012226 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117012227 MarR family; Region: MarR_2; pfam12802 426117012228 Creatinine amidohydrolase; Region: Creatininase; pfam02633 426117012229 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426117012230 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 426117012231 P-loop, Walker A motif; other site 426117012232 Base recognition motif; other site 426117012233 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426117012234 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117012235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117012236 ligand binding site [chemical binding]; other site 426117012237 flexible hinge region; other site 426117012238 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117012239 putative switch regulator; other site 426117012240 non-specific DNA interactions [nucleotide binding]; other site 426117012241 DNA binding site [nucleotide binding] 426117012242 sequence specific DNA binding site [nucleotide binding]; other site 426117012243 putative cAMP binding site [chemical binding]; other site 426117012244 Gas vesicle protein K; Region: GvpK; pfam05121 426117012245 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 426117012246 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 426117012247 glutaminase; Provisional; Region: PRK00971 426117012248 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 426117012249 glutamine synthetase; Region: PLN02284 426117012250 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426117012251 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426117012252 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426117012253 EamA-like transporter family; Region: EamA; pfam00892 426117012254 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117012255 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117012256 active site 426117012257 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426117012258 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426117012259 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426117012260 PAS domain S-box; Region: sensory_box; TIGR00229 426117012261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012262 putative active site [active] 426117012263 heme pocket [chemical binding]; other site 426117012264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117012265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117012266 metal binding site [ion binding]; metal-binding site 426117012267 active site 426117012268 I-site; other site 426117012269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117012270 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 426117012271 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426117012272 putative acyl-acceptor binding pocket; other site 426117012273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117012274 acyl-activating enzyme (AAE) consensus motif; other site 426117012275 AMP binding site [chemical binding]; other site 426117012276 active site 426117012277 CoA binding site [chemical binding]; other site 426117012278 yiaA/B two helix domain; Region: YiaAB; cl01759 426117012279 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 426117012280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117012281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117012282 WHG domain; Region: WHG; pfam13305 426117012283 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 426117012284 active site 426117012285 oligomerization interface [polypeptide binding]; other site 426117012286 metal binding site [ion binding]; metal-binding site 426117012287 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 426117012288 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 426117012289 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117012290 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 426117012291 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426117012292 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 426117012293 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 426117012294 dimerization interface [polypeptide binding]; other site 426117012295 active site 426117012296 L-aspartate oxidase; Provisional; Region: PRK06175 426117012297 quinolinate synthetase; Provisional; Region: PRK09375 426117012298 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 426117012299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 426117012300 Protein of unknown function, DUF482; Region: DUF482; pfam04339 426117012301 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 426117012302 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117012303 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117012304 ligand binding site [chemical binding]; other site 426117012305 flexible hinge region; other site 426117012306 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426117012307 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 426117012308 nucleophile elbow; other site 426117012309 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117012310 Cytochrome P450; Region: p450; cl12078 426117012311 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 426117012312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117012313 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 426117012314 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 426117012315 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 426117012316 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 426117012317 putative dimer interface [polypeptide binding]; other site 426117012318 N-terminal domain interface [polypeptide binding]; other site 426117012319 putative substrate binding pocket (H-site) [chemical binding]; other site 426117012320 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 426117012321 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 426117012322 active site 426117012323 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426117012324 enoyl-CoA hydratase; Provisional; Region: PRK05862 426117012325 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117012326 substrate binding site [chemical binding]; other site 426117012327 oxyanion hole (OAH) forming residues; other site 426117012328 trimer interface [polypeptide binding]; other site 426117012329 serine racemase; Region: PLN02970 426117012330 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426117012331 tetramer interface [polypeptide binding]; other site 426117012332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117012333 catalytic residue [active] 426117012334 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 426117012335 putative deacylase active site [active] 426117012336 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426117012337 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 426117012338 active site clefts [active] 426117012339 zinc binding site [ion binding]; other site 426117012340 dimer interface [polypeptide binding]; other site 426117012341 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 426117012342 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 426117012343 23S rRNA interface [nucleotide binding]; other site 426117012344 L3 interface [polypeptide binding]; other site 426117012345 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426117012346 CoenzymeA binding site [chemical binding]; other site 426117012347 subunit interaction site [polypeptide binding]; other site 426117012348 PHB binding site; other site 426117012349 enoyl-CoA hydratase; Validated; Region: PRK08139 426117012350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117012351 substrate binding site [chemical binding]; other site 426117012352 oxyanion hole (OAH) forming residues; other site 426117012353 trimer interface [polypeptide binding]; other site 426117012354 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 426117012355 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 426117012356 MgtE intracellular N domain; Region: MgtE_N; pfam03448 426117012357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 426117012358 Divalent cation transporter; Region: MgtE; pfam01769 426117012359 Low affinity iron permease; Region: Iron_permease; pfam04120 426117012360 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426117012361 Amidase; Region: Amidase; pfam01425 426117012362 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426117012363 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117012364 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 426117012365 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 426117012366 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 426117012367 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 426117012368 active site 426117012369 intersubunit interface [polypeptide binding]; other site 426117012370 catalytic residue [active] 426117012371 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 426117012372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117012373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117012374 catalytic residue [active] 426117012375 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 426117012376 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012377 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012378 catalytic triad [active] 426117012379 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012380 active site 426117012381 catalytic triad [active] 426117012382 oxyanion hole [active] 426117012383 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012384 oxyanion hole [active] 426117012385 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012386 oxyanion hole [active] 426117012387 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117012388 catalytic triad [active] 426117012389 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 426117012390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012391 PAS fold; Region: PAS_3; pfam08447 426117012392 putative active site [active] 426117012393 heme pocket [chemical binding]; other site 426117012394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117012395 ATP binding site [chemical binding]; other site 426117012396 G-X-G motif; other site 426117012397 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117012398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117012399 active site 426117012400 phosphorylation site [posttranslational modification] 426117012401 intermolecular recognition site; other site 426117012402 dimerization interface [polypeptide binding]; other site 426117012403 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 426117012404 active site 426117012405 catalytic residues [active] 426117012406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426117012407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426117012408 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426117012409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117012410 MarR family; Region: MarR; pfam01047 426117012411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117012412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117012413 DNA binding residues [nucleotide binding] 426117012414 dimerization interface [polypeptide binding]; other site 426117012415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012416 PAS domain; Region: PAS_9; pfam13426 426117012417 putative active site [active] 426117012418 heme pocket [chemical binding]; other site 426117012419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012420 PAS domain; Region: PAS_9; pfam13426 426117012421 putative active site [active] 426117012422 heme pocket [chemical binding]; other site 426117012423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117012424 dimer interface [polypeptide binding]; other site 426117012425 putative CheW interface [polypeptide binding]; other site 426117012426 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 426117012427 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 426117012428 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426117012429 N-terminal plug; other site 426117012430 ligand-binding site [chemical binding]; other site 426117012431 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117012432 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 426117012433 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426117012434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426117012435 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117012436 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117012437 TM-ABC transporter signature motif; other site 426117012438 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117012439 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117012440 Walker A/P-loop; other site 426117012441 ATP binding site [chemical binding]; other site 426117012442 Q-loop/lid; other site 426117012443 ABC transporter signature motif; other site 426117012444 Walker B; other site 426117012445 D-loop; other site 426117012446 H-loop/switch region; other site 426117012447 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117012448 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117012449 Walker A/P-loop; other site 426117012450 ATP binding site [chemical binding]; other site 426117012451 Q-loop/lid; other site 426117012452 ABC transporter signature motif; other site 426117012453 Walker B; other site 426117012454 D-loop; other site 426117012455 H-loop/switch region; other site 426117012456 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117012457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117012458 TM-ABC transporter signature motif; other site 426117012459 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117012460 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117012461 putative ligand binding site [chemical binding]; other site 426117012462 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117012463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117012464 DNA-binding site [nucleotide binding]; DNA binding site 426117012465 short chain dehydrogenase; Provisional; Region: PRK12829 426117012466 classical (c) SDRs; Region: SDR_c; cd05233 426117012467 NAD(P) binding site [chemical binding]; other site 426117012468 active site 426117012469 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 426117012470 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 426117012471 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 426117012472 phosphoglucomutase; Region: PLN02307 426117012473 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 426117012474 active site 426117012475 substrate binding site [chemical binding]; other site 426117012476 metal binding site [ion binding]; metal-binding site 426117012477 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426117012478 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426117012479 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 426117012480 heterodimer interface [polypeptide binding]; other site 426117012481 multimer interface [polypeptide binding]; other site 426117012482 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 426117012483 active site 426117012484 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 426117012485 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 426117012486 heterodimer interface [polypeptide binding]; other site 426117012487 active site 426117012488 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117012489 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 426117012490 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 426117012491 tetramer interface [polypeptide binding]; other site 426117012492 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 426117012493 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426117012494 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426117012495 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426117012496 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426117012497 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 426117012498 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 426117012499 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 426117012500 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426117012501 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426117012502 dimerization interface [polypeptide binding]; other site 426117012503 DPS ferroxidase diiron center [ion binding]; other site 426117012504 ion pore; other site 426117012505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426117012506 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117012507 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426117012508 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 426117012509 metal binding site [ion binding]; metal-binding site 426117012510 putative dimer interface [polypeptide binding]; other site 426117012511 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 426117012512 HIT family signature motif; other site 426117012513 catalytic residue [active] 426117012514 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 426117012515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 426117012516 ATP binding site [chemical binding]; other site 426117012517 putative Mg++ binding site [ion binding]; other site 426117012518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117012519 nucleotide binding region [chemical binding]; other site 426117012520 ATP-binding site [chemical binding]; other site 426117012521 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 426117012522 RNA binding site [nucleotide binding]; other site 426117012523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117012524 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 426117012525 NAD binding site [chemical binding]; other site 426117012526 putative substrate binding site 2 [chemical binding]; other site 426117012527 putative substrate binding site 1 [chemical binding]; other site 426117012528 active site 426117012529 Leucine rich repeat; Region: LRR_8; pfam13855 426117012530 Leucine rich repeat; Region: LRR_8; pfam13855 426117012531 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 426117012532 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 426117012533 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 426117012534 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 426117012535 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426117012536 Predicted acyl esterases [General function prediction only]; Region: COG2936 426117012537 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 426117012538 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 426117012539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117012540 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 426117012541 active site 426117012542 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426117012543 Isochorismatase family; Region: Isochorismatase; pfam00857 426117012544 catalytic triad [active] 426117012545 conserved cis-peptide bond; other site 426117012546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117012547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117012548 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117012549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012550 dimer interface [polypeptide binding]; other site 426117012551 conserved gate region; other site 426117012552 putative PBP binding loops; other site 426117012553 ABC-ATPase subunit interface; other site 426117012554 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117012555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117012556 Walker A/P-loop; other site 426117012557 ATP binding site [chemical binding]; other site 426117012558 Q-loop/lid; other site 426117012559 ABC transporter signature motif; other site 426117012560 Walker B; other site 426117012561 D-loop; other site 426117012562 H-loop/switch region; other site 426117012563 TOBE domain; Region: TOBE_2; pfam08402 426117012564 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426117012565 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 426117012566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012567 dimer interface [polypeptide binding]; other site 426117012568 conserved gate region; other site 426117012569 putative PBP binding loops; other site 426117012570 ABC-ATPase subunit interface; other site 426117012571 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117012572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117012573 active site 426117012574 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117012575 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117012576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117012577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117012578 DNA binding residues [nucleotide binding] 426117012579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012580 PAS domain; Region: PAS_9; pfam13426 426117012581 putative active site [active] 426117012582 heme pocket [chemical binding]; other site 426117012583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012584 PAS domain; Region: PAS_9; pfam13426 426117012585 putative active site [active] 426117012586 heme pocket [chemical binding]; other site 426117012587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117012588 dimer interface [polypeptide binding]; other site 426117012589 putative CheW interface [polypeptide binding]; other site 426117012590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117012591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117012592 NAD(P) binding site [chemical binding]; other site 426117012593 active site 426117012594 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117012595 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117012596 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117012597 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 426117012598 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 426117012599 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 426117012600 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 426117012601 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 426117012602 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117012603 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 426117012604 dimerization interface [polypeptide binding]; other site 426117012605 ligand binding site [chemical binding]; other site 426117012606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117012607 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117012608 Integrase core domain; Region: rve; pfam00665 426117012609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117012610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117012611 Walker A motif; other site 426117012612 ATP binding site [chemical binding]; other site 426117012613 Walker B motif; other site 426117012614 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 426117012615 Dodecin; Region: Dodecin; pfam07311 426117012616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117012617 HTH-like domain; Region: HTH_21; pfam13276 426117012618 PAS domain; Region: PAS; smart00091 426117012619 putative active site [active] 426117012620 heme pocket [chemical binding]; other site 426117012621 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 426117012622 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426117012623 PAS fold; Region: PAS_3; pfam08447 426117012624 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426117012625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117012626 dimer interface [polypeptide binding]; other site 426117012627 phosphorylation site [posttranslational modification] 426117012628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117012629 ATP binding site [chemical binding]; other site 426117012630 Mg2+ binding site [ion binding]; other site 426117012631 G-X-G motif; other site 426117012632 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117012633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117012634 active site 426117012635 phosphorylation site [posttranslational modification] 426117012636 intermolecular recognition site; other site 426117012637 dimerization interface [polypeptide binding]; other site 426117012638 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 426117012639 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117012640 Walker A motif; other site 426117012641 ATP binding site [chemical binding]; other site 426117012642 Walker B motif; other site 426117012643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117012644 ATP binding site [chemical binding]; other site 426117012645 Walker A motif; other site 426117012646 Walker B motif; other site 426117012647 Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Region: PI3K_1B_p101; pfam10486 426117012648 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 426117012649 cobalamin binding residues [chemical binding]; other site 426117012650 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 426117012651 putative BtuC binding residues; other site 426117012652 dimer interface [polypeptide binding]; other site 426117012653 choline dehydrogenase; Validated; Region: PRK02106 426117012654 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426117012655 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 426117012656 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117012657 BON domain; Region: BON; pfam04972 426117012658 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 426117012659 SnoaL-like domain; Region: SnoaL_3; pfam13474 426117012660 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 426117012661 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117012662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117012663 Walker A/P-loop; other site 426117012664 ATP binding site [chemical binding]; other site 426117012665 Q-loop/lid; other site 426117012666 ABC transporter signature motif; other site 426117012667 Walker B; other site 426117012668 D-loop; other site 426117012669 H-loop/switch region; other site 426117012670 TOBE domain; Region: TOBE_2; pfam08402 426117012671 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426117012672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117012673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012674 dimer interface [polypeptide binding]; other site 426117012675 conserved gate region; other site 426117012676 putative PBP binding loops; other site 426117012677 ABC-ATPase subunit interface; other site 426117012678 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117012679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012680 dimer interface [polypeptide binding]; other site 426117012681 conserved gate region; other site 426117012682 putative PBP binding loops; other site 426117012683 ABC-ATPase subunit interface; other site 426117012684 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117012685 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 426117012686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117012687 S-adenosylmethionine binding site [chemical binding]; other site 426117012688 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 426117012689 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 426117012690 active site 426117012691 catalytic site [active] 426117012692 aspartate kinase; Reviewed; Region: PRK06635 426117012693 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 426117012694 putative nucleotide binding site [chemical binding]; other site 426117012695 putative catalytic residues [active] 426117012696 putative Mg ion binding site [ion binding]; other site 426117012697 putative aspartate binding site [chemical binding]; other site 426117012698 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 426117012699 putative allosteric regulatory site; other site 426117012700 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 426117012701 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 426117012702 GAF domain; Region: GAF; pfam01590 426117012703 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 426117012704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426117012705 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426117012706 peptide chain release factor 1; Validated; Region: prfA; PRK00591 426117012707 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426117012708 RF-1 domain; Region: RF-1; pfam00472 426117012709 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 426117012710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117012711 S-adenosylmethionine binding site [chemical binding]; other site 426117012712 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 426117012713 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 426117012714 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117012715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117012716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117012717 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 426117012718 putative dimerization interface [polypeptide binding]; other site 426117012719 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 426117012720 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 426117012721 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 426117012722 shikimate binding site; other site 426117012723 NAD(P) binding site [chemical binding]; other site 426117012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117012725 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117012726 putative substrate translocation pore; other site 426117012727 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 426117012728 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 426117012729 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 426117012730 dimer interface [polypeptide binding]; other site 426117012731 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 426117012732 active site 426117012733 Fe binding site [ion binding]; other site 426117012734 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 426117012735 Dehydroquinase class II; Region: DHquinase_II; pfam01220 426117012736 trimer interface [polypeptide binding]; other site 426117012737 active site 426117012738 dimer interface [polypeptide binding]; other site 426117012739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117012740 NAD(P) binding site [chemical binding]; other site 426117012741 active site 426117012742 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 426117012743 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117012744 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 426117012745 putative ligand binding site [chemical binding]; other site 426117012746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117012747 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 426117012748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117012749 dimerization interface [polypeptide binding]; other site 426117012750 EamA-like transporter family; Region: EamA; pfam00892 426117012751 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117012752 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 426117012753 putative ligand binding site [chemical binding]; other site 426117012754 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117012755 TM-ABC transporter signature motif; other site 426117012756 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117012757 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117012758 TM-ABC transporter signature motif; other site 426117012759 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117012760 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117012761 Walker A/P-loop; other site 426117012762 ATP binding site [chemical binding]; other site 426117012763 Q-loop/lid; other site 426117012764 ABC transporter signature motif; other site 426117012765 Walker B; other site 426117012766 D-loop; other site 426117012767 H-loop/switch region; other site 426117012768 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117012769 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117012770 Walker A/P-loop; other site 426117012771 ATP binding site [chemical binding]; other site 426117012772 Q-loop/lid; other site 426117012773 ABC transporter signature motif; other site 426117012774 Walker B; other site 426117012775 D-loop; other site 426117012776 H-loop/switch region; other site 426117012777 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 426117012778 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 426117012779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117012780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117012781 sequence-specific DNA binding site [nucleotide binding]; other site 426117012782 salt bridge; other site 426117012783 Cupin domain; Region: Cupin_2; pfam07883 426117012784 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426117012785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117012786 active site 426117012787 phosphorylation site [posttranslational modification] 426117012788 intermolecular recognition site; other site 426117012789 dimerization interface [polypeptide binding]; other site 426117012790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117012791 Walker A motif; other site 426117012792 ATP binding site [chemical binding]; other site 426117012793 Walker B motif; other site 426117012794 arginine finger; other site 426117012795 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 426117012796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117012797 dimer interface [polypeptide binding]; other site 426117012798 phosphorylation site [posttranslational modification] 426117012799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117012800 ATP binding site [chemical binding]; other site 426117012801 Mg2+ binding site [ion binding]; other site 426117012802 G-X-G motif; other site 426117012803 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426117012804 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117012805 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117012806 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117012807 active site 426117012808 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117012809 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117012810 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 426117012811 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426117012812 active site 426117012813 dimer interface [polypeptide binding]; other site 426117012814 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 426117012815 glutathione reductase; Validated; Region: PRK06116 426117012816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426117012817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117012818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426117012819 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 426117012820 glucosyltransferase MdoH; Provisional; Region: PRK05454 426117012821 active site 426117012822 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117012823 NAD(P) binding site [chemical binding]; other site 426117012824 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 426117012825 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117012826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117012827 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 426117012828 RNA polymerase sigma factor; Provisional; Region: PRK12533 426117012829 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 426117012830 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117012831 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117012832 active site 426117012833 metal binding site [ion binding]; metal-binding site 426117012834 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426117012835 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 426117012836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117012837 catalytic loop [active] 426117012838 iron binding site [ion binding]; other site 426117012839 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117012840 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117012841 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117012842 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117012843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 426117012844 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 426117012845 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 426117012846 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 426117012847 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426117012848 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426117012849 active site 426117012850 nucleophile elbow; other site 426117012851 Patatin phospholipase; Region: DUF3734; pfam12536 426117012852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117012853 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 426117012854 NAD(P) binding site [chemical binding]; other site 426117012855 active site 426117012856 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426117012857 Amidase; Region: Amidase; cl11426 426117012858 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426117012859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117012860 ATP binding site [chemical binding]; other site 426117012861 putative Mg++ binding site [ion binding]; other site 426117012862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117012863 nucleotide binding region [chemical binding]; other site 426117012864 ATP-binding site [chemical binding]; other site 426117012865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117012866 RNA binding surface [nucleotide binding]; other site 426117012867 Ferredoxin [Energy production and conversion]; Region: COG1146 426117012868 4Fe-4S binding domain; Region: Fer4; pfam00037 426117012869 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 426117012870 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 426117012871 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 426117012872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117012873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117012874 DNA binding residues [nucleotide binding] 426117012875 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 426117012876 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 426117012877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117012878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117012879 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426117012880 putative effector binding pocket; other site 426117012881 dimerization interface [polypeptide binding]; other site 426117012882 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 426117012883 heterotetramer interface [polypeptide binding]; other site 426117012884 active site pocket [active] 426117012885 cleavage site 426117012886 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 426117012887 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 426117012888 active site 426117012889 8-oxo-dGMP binding site [chemical binding]; other site 426117012890 nudix motif; other site 426117012891 metal binding site [ion binding]; metal-binding site 426117012892 Domain of unknown function (DUF427); Region: DUF427; pfam04248 426117012893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117012894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117012895 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 426117012896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117012897 active site 426117012898 cyanate hydratase; Validated; Region: PRK02866 426117012899 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 426117012900 oligomer interface [polypeptide binding]; other site 426117012901 active site 426117012902 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117012903 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426117012904 Walker A/P-loop; other site 426117012905 ATP binding site [chemical binding]; other site 426117012906 Q-loop/lid; other site 426117012907 ABC transporter signature motif; other site 426117012908 Walker B; other site 426117012909 D-loop; other site 426117012910 H-loop/switch region; other site 426117012911 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117012912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117012913 dimer interface [polypeptide binding]; other site 426117012914 conserved gate region; other site 426117012915 putative PBP binding loops; other site 426117012916 ABC-ATPase subunit interface; other site 426117012917 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426117012918 NMT1-like family; Region: NMT1_2; pfam13379 426117012919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012920 PAS domain; Region: PAS_9; pfam13426 426117012921 putative active site [active] 426117012922 heme pocket [chemical binding]; other site 426117012923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117012924 PAS domain; Region: PAS_9; pfam13426 426117012925 putative active site [active] 426117012926 heme pocket [chemical binding]; other site 426117012927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117012928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117012929 Walker A motif; other site 426117012930 ATP binding site [chemical binding]; other site 426117012931 Walker B motif; other site 426117012932 arginine finger; other site 426117012933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117012934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117012935 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 426117012936 classical (c) SDRs; Region: SDR_c; cd05233 426117012937 NAD(P) binding site [chemical binding]; other site 426117012938 active site 426117012939 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 426117012940 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 426117012941 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 426117012942 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 426117012943 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426117012944 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 426117012945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117012946 putative substrate translocation pore; other site 426117012947 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117012948 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 426117012949 putative C-terminal domain interface [polypeptide binding]; other site 426117012950 putative GSH binding site (G-site) [chemical binding]; other site 426117012951 putative dimer interface [polypeptide binding]; other site 426117012952 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 426117012953 dimer interface [polypeptide binding]; other site 426117012954 N-terminal domain interface [polypeptide binding]; other site 426117012955 putative substrate binding pocket (H-site) [chemical binding]; other site 426117012956 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 426117012957 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 426117012958 rRNA interaction site [nucleotide binding]; other site 426117012959 S8 interaction site; other site 426117012960 putative laminin-1 binding site; other site 426117012961 Uncharacterized conserved protein [Function unknown]; Region: COG3743 426117012962 elongation factor Ts; Provisional; Region: tsf; PRK09377 426117012963 UBA/TS-N domain; Region: UBA; pfam00627 426117012964 Elongation factor TS; Region: EF_TS; pfam00889 426117012965 Elongation factor TS; Region: EF_TS; pfam00889 426117012966 Cupin domain; Region: Cupin_2; pfam07883 426117012967 shikimate transporter; Provisional; Region: PRK09952 426117012968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117012969 putative substrate translocation pore; other site 426117012970 MOSC domain; Region: MOSC; pfam03473 426117012971 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426117012972 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 426117012973 FMN-binding pocket [chemical binding]; other site 426117012974 flavin binding motif; other site 426117012975 phosphate binding motif [ion binding]; other site 426117012976 beta-alpha-beta structure motif; other site 426117012977 NAD binding pocket [chemical binding]; other site 426117012978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117012979 catalytic loop [active] 426117012980 iron binding site [ion binding]; other site 426117012981 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426117012982 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426117012983 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426117012984 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426117012985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117012986 active site 426117012987 phosphorylation site [posttranslational modification] 426117012988 intermolecular recognition site; other site 426117012989 dimerization interface [polypeptide binding]; other site 426117012990 CheB methylesterase; Region: CheB_methylest; pfam01339 426117012991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117012992 Response regulator receiver domain; Region: Response_reg; pfam00072 426117012993 active site 426117012994 phosphorylation site [posttranslational modification] 426117012995 intermolecular recognition site; other site 426117012996 dimerization interface [polypeptide binding]; other site 426117012997 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426117012998 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426117012999 putative binding surface; other site 426117013000 active site 426117013001 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 426117013002 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 426117013003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013004 ATP binding site [chemical binding]; other site 426117013005 Mg2+ binding site [ion binding]; other site 426117013006 G-X-G motif; other site 426117013007 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 426117013008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117013009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013010 active site 426117013011 phosphorylation site [posttranslational modification] 426117013012 intermolecular recognition site; other site 426117013013 dimerization interface [polypeptide binding]; other site 426117013014 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 426117013015 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 426117013016 active site 426117013017 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 426117013018 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 426117013019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013020 dimer interface [polypeptide binding]; other site 426117013021 phosphorylation site [posttranslational modification] 426117013022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013023 ATP binding site [chemical binding]; other site 426117013024 Mg2+ binding site [ion binding]; other site 426117013025 G-X-G motif; other site 426117013026 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013028 active site 426117013029 phosphorylation site [posttranslational modification] 426117013030 intermolecular recognition site; other site 426117013031 dimerization interface [polypeptide binding]; other site 426117013032 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 426117013033 diaminopimelate decarboxylase; Region: lysA; TIGR01048 426117013034 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 426117013035 active site 426117013036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426117013037 substrate binding site [chemical binding]; other site 426117013038 catalytic residues [active] 426117013039 dimer interface [polypeptide binding]; other site 426117013040 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 426117013041 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 426117013042 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 426117013043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117013044 Histidine kinase; Region: HisKA_2; pfam07568 426117013045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 426117013046 ATP binding site [chemical binding]; other site 426117013047 Mg2+ binding site [ion binding]; other site 426117013048 G-X-G motif; other site 426117013049 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117013050 acyl carrier protein; Provisional; Region: PRK06508 426117013051 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 426117013052 active site 2 [active] 426117013053 active site 1 [active] 426117013054 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 426117013055 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 426117013056 active site 426117013057 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 426117013058 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426117013059 dimer interface [polypeptide binding]; other site 426117013060 active site 426117013061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117013062 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 426117013063 NAD(P) binding site [chemical binding]; other site 426117013064 active site 426117013065 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117013066 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426117013067 NAD(P) binding site [chemical binding]; other site 426117013068 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 426117013069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 426117013070 putative acyl-acceptor binding pocket; other site 426117013071 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 426117013072 transcriptional regulator SlyA; Provisional; Region: PRK03573 426117013073 MarR family; Region: MarR; pfam01047 426117013074 Fusaric acid resistance protein family; Region: FUSC; pfam04632 426117013075 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 426117013076 HlyD family secretion protein; Region: HlyD; pfam00529 426117013077 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117013078 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117013079 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117013080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013081 putative substrate translocation pore; other site 426117013082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013083 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 426117013084 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 426117013085 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117013086 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117013087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117013088 catalytic residue [active] 426117013089 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 426117013090 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 426117013091 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 426117013092 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 426117013093 active site 426117013094 catalytic site [active] 426117013095 histidine kinase; Provisional; Region: PRK13557 426117013096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117013097 putative active site [active] 426117013098 heme pocket [chemical binding]; other site 426117013099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013100 dimer interface [polypeptide binding]; other site 426117013101 phosphorylation site [posttranslational modification] 426117013102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013103 ATP binding site [chemical binding]; other site 426117013104 Mg2+ binding site [ion binding]; other site 426117013105 G-X-G motif; other site 426117013106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013107 active site 426117013108 phosphorylation site [posttranslational modification] 426117013109 intermolecular recognition site; other site 426117013110 dimerization interface [polypeptide binding]; other site 426117013111 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426117013112 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 426117013113 conserved cys residue [active] 426117013114 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426117013115 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426117013116 conserved cys residue [active] 426117013117 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117013118 active site 426117013119 HIGH motif; other site 426117013120 nucleotide binding site [chemical binding]; other site 426117013121 active site 426117013122 KMSKS motif; other site 426117013123 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 426117013124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426117013125 minor groove reading motif; other site 426117013126 helix-hairpin-helix signature motif; other site 426117013127 active site 426117013128 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 426117013129 putative hydrolase; Provisional; Region: PRK11460 426117013130 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 426117013131 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 426117013132 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 426117013133 ATP binding site [chemical binding]; other site 426117013134 active site 426117013135 substrate binding site [chemical binding]; other site 426117013136 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426117013137 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426117013138 Probable Catalytic site; other site 426117013139 metal-binding site 426117013140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117013141 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426117013142 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426117013143 Probable Catalytic site; other site 426117013144 metal-binding site 426117013145 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426117013146 Protein of unknown function DUF45; Region: DUF45; pfam01863 426117013147 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 426117013148 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426117013149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117013151 dimer interface [polypeptide binding]; other site 426117013152 phosphorylation site [posttranslational modification] 426117013153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013154 ATP binding site [chemical binding]; other site 426117013155 Mg2+ binding site [ion binding]; other site 426117013156 G-X-G motif; other site 426117013157 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 426117013158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013159 active site 426117013160 phosphorylation site [posttranslational modification] 426117013161 intermolecular recognition site; other site 426117013162 dimerization interface [polypeptide binding]; other site 426117013163 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 426117013164 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 426117013165 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426117013166 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426117013167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 426117013168 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426117013169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117013170 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 426117013171 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426117013172 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426117013173 Moco binding site; other site 426117013174 metal coordination site [ion binding]; other site 426117013175 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 426117013176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117013177 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117013178 FeS/SAM binding site; other site 426117013179 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 426117013180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117013181 active site 426117013182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117013183 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 426117013184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117013185 homodimer interface [polypeptide binding]; other site 426117013186 catalytic residue [active] 426117013187 aspartate aminotransferase; Provisional; Region: PRK05764 426117013188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117013189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117013190 homodimer interface [polypeptide binding]; other site 426117013191 catalytic residue [active] 426117013192 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 426117013193 NAD synthetase; Reviewed; Region: nadE; PRK02628 426117013194 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 426117013195 multimer interface [polypeptide binding]; other site 426117013196 active site 426117013197 catalytic triad [active] 426117013198 protein interface 1 [polypeptide binding]; other site 426117013199 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 426117013200 homodimer interface [polypeptide binding]; other site 426117013201 NAD binding pocket [chemical binding]; other site 426117013202 ATP binding pocket [chemical binding]; other site 426117013203 Mg binding site [ion binding]; other site 426117013204 active-site loop [active] 426117013205 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 426117013206 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426117013207 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 426117013208 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 426117013209 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 426117013210 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 426117013211 putative catalytic site [active] 426117013212 putative phosphate binding site [ion binding]; other site 426117013213 active site 426117013214 metal binding site A [ion binding]; metal-binding site 426117013215 DNA binding site [nucleotide binding] 426117013216 putative AP binding site [nucleotide binding]; other site 426117013217 putative metal binding site B [ion binding]; other site 426117013218 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426117013219 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426117013220 Bacterial transcriptional regulator; Region: IclR; pfam01614 426117013221 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117013222 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117013223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117013224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117013225 NAD(P) binding site [chemical binding]; other site 426117013226 active site 426117013227 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117013228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013229 putative substrate translocation pore; other site 426117013230 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 426117013231 16S/18S rRNA binding site [nucleotide binding]; other site 426117013232 S13e-L30e interaction site [polypeptide binding]; other site 426117013233 25S rRNA binding site [nucleotide binding]; other site 426117013234 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 426117013235 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 426117013236 RNase E interface [polypeptide binding]; other site 426117013237 trimer interface [polypeptide binding]; other site 426117013238 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 426117013239 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 426117013240 RNase E interface [polypeptide binding]; other site 426117013241 trimer interface [polypeptide binding]; other site 426117013242 active site 426117013243 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 426117013244 putative nucleic acid binding region [nucleotide binding]; other site 426117013245 G-X-X-G motif; other site 426117013246 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 426117013247 RNA binding site [nucleotide binding]; other site 426117013248 domain interface; other site 426117013249 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 426117013250 Predicted membrane protein [Function unknown]; Region: COG2261 426117013251 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 426117013252 homotrimer interaction site [polypeptide binding]; other site 426117013253 putative active site [active] 426117013254 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426117013255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117013256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117013257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013258 active site 426117013259 phosphorylation site [posttranslational modification] 426117013260 intermolecular recognition site; other site 426117013261 dimerization interface [polypeptide binding]; other site 426117013262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117013263 DNA binding residues [nucleotide binding] 426117013264 dimerization interface [polypeptide binding]; other site 426117013265 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426117013266 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426117013267 Predicted permeases [General function prediction only]; Region: RarD; COG2962 426117013268 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 426117013269 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426117013270 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426117013271 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 426117013272 Permease; Region: Permease; pfam02405 426117013273 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 426117013274 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 426117013275 Walker A/P-loop; other site 426117013276 ATP binding site [chemical binding]; other site 426117013277 Q-loop/lid; other site 426117013278 ABC transporter signature motif; other site 426117013279 Walker B; other site 426117013280 D-loop; other site 426117013281 H-loop/switch region; other site 426117013282 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 426117013283 mce related protein; Region: MCE; pfam02470 426117013284 Protein of unknown function (DUF330); Region: DUF330; cl01135 426117013285 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117013286 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 426117013287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117013288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117013289 non-specific DNA binding site [nucleotide binding]; other site 426117013290 salt bridge; other site 426117013291 sequence-specific DNA binding site [nucleotide binding]; other site 426117013292 Cupin domain; Region: Cupin_2; pfam07883 426117013293 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 426117013294 dimer interface [polypeptide binding]; other site 426117013295 substrate binding site [chemical binding]; other site 426117013296 ATP binding site [chemical binding]; other site 426117013297 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426117013298 active site 426117013299 pyrophosphate binding site [ion binding]; other site 426117013300 thiamine phosphate binding site [chemical binding]; other site 426117013301 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426117013302 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 426117013303 putative active site [active] 426117013304 putative metal binding site [ion binding]; other site 426117013305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117013306 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 426117013307 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117013308 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426117013309 putative cation:proton antiport protein; Provisional; Region: PRK10669 426117013310 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 426117013311 TrkA-N domain; Region: TrkA_N; pfam02254 426117013312 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 426117013313 Adenoviral DNA terminal protein; Region: Adeno_terminal; pfam02459 426117013314 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 426117013315 MarR family; Region: MarR_2; cl17246 426117013316 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426117013317 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117013318 catalytic residues [active] 426117013319 catalytic nucleophile [active] 426117013320 Recombinase; Region: Recombinase; pfam07508 426117013321 ParB-like nuclease domain; Region: ParB; smart00470 426117013322 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426117013323 active site 426117013324 Int/Topo IB signature motif; other site 426117013325 DNA binding site [nucleotide binding] 426117013326 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426117013327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117013328 S-adenosylmethionine binding site [chemical binding]; other site 426117013329 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426117013330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117013331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117013332 ligand binding site [chemical binding]; other site 426117013333 flexible hinge region; other site 426117013334 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117013335 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117013336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426117013337 active site 426117013338 Putative methyltransferase; Region: Methyltransf_4; cl17290 426117013339 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426117013340 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 426117013341 substrate binding site; other site 426117013342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117013343 extended (e) SDRs; Region: SDR_e; cd08946 426117013344 NAD(P) binding site [chemical binding]; other site 426117013345 active site 426117013346 substrate binding site [chemical binding]; other site 426117013347 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426117013348 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 426117013349 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 426117013350 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117013351 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426117013352 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 426117013353 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117013354 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 426117013355 putative active site [active] 426117013356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117013357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117013358 active site 426117013359 catalytic tetrad [active] 426117013360 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117013361 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 426117013362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117013363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013364 active site 426117013365 phosphorylation site [posttranslational modification] 426117013366 dimerization interface [polypeptide binding]; other site 426117013367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117013368 DNA binding residues [nucleotide binding] 426117013369 dimerization interface [polypeptide binding]; other site 426117013370 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 426117013371 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 426117013372 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 426117013373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117013374 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 426117013375 M28 Zn-Peptidases; Region: M28_like_3; cd05644 426117013376 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 426117013377 active site 426117013378 metal binding site [ion binding]; metal-binding site 426117013379 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 426117013380 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426117013381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117013382 S-adenosylmethionine binding site [chemical binding]; other site 426117013383 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 426117013384 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 426117013385 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 426117013386 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426117013387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117013388 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117013389 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117013390 putative switch regulator; other site 426117013391 non-specific DNA interactions [nucleotide binding]; other site 426117013392 DNA binding site [nucleotide binding] 426117013393 sequence specific DNA binding site [nucleotide binding]; other site 426117013394 putative cAMP binding site [chemical binding]; other site 426117013395 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117013396 MarR family; Region: MarR; pfam01047 426117013397 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 426117013398 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 426117013399 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117013400 EamA-like transporter family; Region: EamA; pfam00892 426117013401 aromatic amino acid exporter; Provisional; Region: PRK11689 426117013402 Cupin domain; Region: Cupin_2; cl17218 426117013403 Helix-turn-helix domain; Region: HTH_18; pfam12833 426117013404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117013405 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 426117013406 nudix motif; other site 426117013407 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117013408 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117013409 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426117013410 FAD binding domain; Region: FAD_binding_4; pfam01565 426117013411 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 426117013412 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426117013413 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426117013414 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426117013415 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426117013416 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 426117013417 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 426117013418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117013419 Walker A/P-loop; other site 426117013420 ATP binding site [chemical binding]; other site 426117013421 Q-loop/lid; other site 426117013422 ABC transporter signature motif; other site 426117013423 Walker B; other site 426117013424 D-loop; other site 426117013425 H-loop/switch region; other site 426117013426 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426117013427 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013428 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013429 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013430 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117013431 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426117013432 ligand binding site [chemical binding]; other site 426117013433 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 426117013434 hypothetical protein; Provisional; Region: PRK02227 426117013435 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 426117013436 nucleotide binding site [chemical binding]; other site 426117013437 substrate binding site [chemical binding]; other site 426117013438 dihydropteroate synthase-related protein; Region: TIGR00284 426117013439 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 426117013440 substrate binding pocket [chemical binding]; other site 426117013441 dimer interface [polypeptide binding]; other site 426117013442 inhibitor binding site; inhibition site 426117013443 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 426117013444 Protein of unknown function (DUF447); Region: DUF447; pfam04289 426117013445 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426117013446 putative hydrophobic ligand binding site [chemical binding]; other site 426117013447 protein interface [polypeptide binding]; other site 426117013448 gate; other site 426117013449 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426117013450 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013451 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013452 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426117013453 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 426117013454 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 426117013455 active site 426117013456 dimer interface [polypeptide binding]; other site 426117013457 non-prolyl cis peptide bond; other site 426117013458 insertion regions; other site 426117013459 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426117013460 catalytic residues [active] 426117013461 dimer interface [polypeptide binding]; other site 426117013462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 426117013463 SnoaL-like domain; Region: SnoaL_2; pfam12680 426117013464 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 426117013465 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426117013466 Caspase domain; Region: Peptidase_C14; pfam00656 426117013467 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 426117013468 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 426117013469 Caspase domain; Region: Peptidase_C14; pfam00656 426117013470 Uncharacterized conserved protein [Function unknown]; Region: COG1262 426117013471 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 426117013472 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 426117013473 hypothetical protein; Provisional; Region: PRK07338 426117013474 metal binding site [ion binding]; metal-binding site 426117013475 dimer interface [polypeptide binding]; other site 426117013476 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 426117013477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117013478 Zn2+ binding site [ion binding]; other site 426117013479 Mg2+ binding site [ion binding]; other site 426117013480 Transcriptional regulator; Region: Rrf2; pfam02082 426117013481 Predicted transcriptional regulator [Transcription]; Region: COG1959 426117013482 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 426117013483 trimer interface [polypeptide binding]; other site 426117013484 active site 426117013485 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426117013486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117013487 DNA-binding site [nucleotide binding]; DNA binding site 426117013488 FCD domain; Region: FCD; pfam07729 426117013489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013490 putative substrate translocation pore; other site 426117013491 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 426117013492 amidase; Provisional; Region: PRK07056 426117013493 amidase; Validated; Region: PRK05962 426117013494 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426117013495 active site 426117013496 homodimer interface [polypeptide binding]; other site 426117013497 homotetramer interface [polypeptide binding]; other site 426117013498 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013500 active site 426117013501 phosphorylation site [posttranslational modification] 426117013502 intermolecular recognition site; other site 426117013503 dimerization interface [polypeptide binding]; other site 426117013504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117013505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117013506 metal binding site [ion binding]; metal-binding site 426117013507 active site 426117013508 I-site; other site 426117013509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117013510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117013511 DNA binding residues [nucleotide binding] 426117013512 dimerization interface [polypeptide binding]; other site 426117013513 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 426117013514 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 426117013515 active site 426117013516 DNA binding site [nucleotide binding] 426117013517 Int/Topo IB signature motif; other site 426117013518 catalytic residues [active] 426117013519 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117013520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117013521 Predicted methyltransferase [General function prediction only]; Region: COG3897 426117013522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117013523 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426117013524 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426117013525 nucleophile elbow; other site 426117013526 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 426117013527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 426117013528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 426117013529 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 426117013530 potassium uptake protein; Region: kup; TIGR00794 426117013531 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117013532 RNA polymerase sigma factor; Provisional; Region: PRK12512 426117013533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117013534 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 426117013535 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 426117013536 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117013537 Sel1-like repeats; Region: SEL1; smart00671 426117013538 Sel1-like repeats; Region: SEL1; smart00671 426117013539 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117013540 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 426117013541 C-terminal domain interface [polypeptide binding]; other site 426117013542 GSH binding site (G-site) [chemical binding]; other site 426117013543 dimer interface [polypeptide binding]; other site 426117013544 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 426117013545 N-terminal domain interface [polypeptide binding]; other site 426117013546 dimer interface [polypeptide binding]; other site 426117013547 substrate binding pocket (H-site) [chemical binding]; other site 426117013548 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 426117013549 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426117013550 IucA / IucC family; Region: IucA_IucC; pfam04183 426117013551 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426117013552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 426117013553 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 426117013554 IucA / IucC family; Region: IucA_IucC; pfam04183 426117013555 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426117013556 muropeptide transporter; Validated; Region: ampG; cl17669 426117013557 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117013558 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 426117013559 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 426117013560 active site 426117013561 catalytic site [active] 426117013562 tetramer interface [polypeptide binding]; other site 426117013563 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 426117013564 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426117013565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117013566 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 426117013567 active site residue [active] 426117013568 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426117013569 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117013570 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117013571 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 426117013572 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117013573 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117013574 putative ligand binding site [chemical binding]; other site 426117013575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 426117013576 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 426117013577 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426117013578 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426117013579 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426117013580 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 426117013581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 426117013582 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 426117013583 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 426117013584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 426117013585 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426117013586 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426117013587 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426117013588 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 426117013589 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 426117013590 Ribonuclease P; Region: Ribonuclease_P; pfam00825 426117013591 membrane protein insertase; Provisional; Region: PRK01318 426117013592 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 426117013593 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 426117013594 G1 box; other site 426117013595 GTP/Mg2+ binding site [chemical binding]; other site 426117013596 Switch I region; other site 426117013597 G2 box; other site 426117013598 G3 box; other site 426117013599 Switch II region; other site 426117013600 G4 box; other site 426117013601 G5 box; other site 426117013602 Protein of unknown function (DUF423); Region: DUF423; pfam04241 426117013603 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 426117013604 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117013605 active site 426117013606 metal binding site [ion binding]; metal-binding site 426117013607 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 426117013608 Clp amino terminal domain; Region: Clp_N; pfam02861 426117013609 Clp amino terminal domain; Region: Clp_N; pfam02861 426117013610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117013611 Walker A motif; other site 426117013612 ATP binding site [chemical binding]; other site 426117013613 Walker B motif; other site 426117013614 arginine finger; other site 426117013615 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 426117013616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117013617 Walker A motif; other site 426117013618 ATP binding site [chemical binding]; other site 426117013619 Walker B motif; other site 426117013620 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426117013621 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 426117013622 MOSC domain; Region: MOSC; pfam03473 426117013623 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117013624 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 426117013625 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426117013626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117013627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013628 D-galactonate transporter; Region: 2A0114; TIGR00893 426117013629 putative substrate translocation pore; other site 426117013630 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 426117013631 active site 426117013632 catalytic residues [active] 426117013633 metal binding site [ion binding]; metal-binding site 426117013634 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426117013635 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117013636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013637 dimerization interface [polypeptide binding]; other site 426117013638 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117013639 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117013640 dimer interface [polypeptide binding]; other site 426117013641 putative CheW interface [polypeptide binding]; other site 426117013642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117013643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117013644 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 426117013645 putative dimerization interface [polypeptide binding]; other site 426117013646 DoxX-like family; Region: DoxX_2; pfam13564 426117013647 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 426117013648 interface (dimer of trimers) [polypeptide binding]; other site 426117013649 multifunctional aminopeptidase A; Provisional; Region: PRK00913 426117013650 Substrate-binding/catalytic site; other site 426117013651 Zn-binding sites [ion binding]; other site 426117013652 Predicted permeases [General function prediction only]; Region: COG0795 426117013653 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 426117013654 Predicted permeases [General function prediction only]; Region: COG0795 426117013655 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 426117013656 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 426117013657 Organic solvent tolerance protein; Region: OstA_C; pfam04453 426117013658 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 426117013659 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 426117013660 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 426117013661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117013662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 426117013663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013664 dimer interface [polypeptide binding]; other site 426117013665 phosphorylation site [posttranslational modification] 426117013666 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 426117013667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013668 ATP binding site [chemical binding]; other site 426117013669 Mg2+ binding site [ion binding]; other site 426117013670 G-X-G motif; other site 426117013671 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 426117013672 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426117013673 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 426117013674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117013675 catalytic residue [active] 426117013676 FeS assembly protein SufD; Region: sufD; TIGR01981 426117013677 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 426117013678 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 426117013679 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 426117013680 Walker A/P-loop; other site 426117013681 ATP binding site [chemical binding]; other site 426117013682 Q-loop/lid; other site 426117013683 ABC transporter signature motif; other site 426117013684 Walker B; other site 426117013685 D-loop; other site 426117013686 H-loop/switch region; other site 426117013687 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 426117013688 putative ABC transporter; Region: ycf24; CHL00085 426117013689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117013690 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 426117013691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117013692 catalytic residue [active] 426117013693 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 426117013694 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 426117013695 putative active site [active] 426117013696 Domain of unknown function DUF87; Region: DUF87; pfam01935 426117013697 AAA-like domain; Region: AAA_10; pfam12846 426117013698 Zonular occludens toxin (Zot); Region: Zot; cl17485 426117013699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117013700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013701 ATP binding site [chemical binding]; other site 426117013702 Mg2+ binding site [ion binding]; other site 426117013703 G-X-G motif; other site 426117013704 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 426117013705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117013706 S-adenosylmethionine binding site [chemical binding]; other site 426117013707 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 426117013708 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 426117013709 Ligand Binding Site [chemical binding]; other site 426117013710 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 426117013711 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 426117013712 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 426117013713 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 426117013714 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 426117013715 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426117013716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117013717 Walker A motif; other site 426117013718 ATP binding site [chemical binding]; other site 426117013719 Walker B motif; other site 426117013720 arginine finger; other site 426117013721 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117013722 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 426117013723 flagellar assembly protein H; Validated; Region: fliH; PRK06032 426117013724 Flagellar assembly protein FliH; Region: FliH; pfam02108 426117013725 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 426117013726 MgtE intracellular N domain; Region: MgtE_N; cl15244 426117013727 FliG C-terminal domain; Region: FliG_C; pfam01706 426117013728 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 426117013729 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 426117013730 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 426117013731 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426117013732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117013733 Walker A/P-loop; other site 426117013734 ATP binding site [chemical binding]; other site 426117013735 Q-loop/lid; other site 426117013736 ABC transporter signature motif; other site 426117013737 Walker B; other site 426117013738 D-loop; other site 426117013739 H-loop/switch region; other site 426117013740 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117013741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117013742 dimer interface [polypeptide binding]; other site 426117013743 conserved gate region; other site 426117013744 putative PBP binding loops; other site 426117013745 ABC-ATPase subunit interface; other site 426117013746 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426117013747 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426117013748 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 426117013749 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 426117013750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426117013751 metal ion-dependent adhesion site (MIDAS); other site 426117013752 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 426117013753 active site 426117013754 catalytic site [active] 426117013755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117013756 non-specific DNA binding site [nucleotide binding]; other site 426117013757 salt bridge; other site 426117013758 sequence-specific DNA binding site [nucleotide binding]; other site 426117013759 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117013760 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426117013761 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117013762 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117013763 Flagellar protein FlbT; Region: FlbT; cl11455 426117013764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426117013765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117013766 Walker A/P-loop; other site 426117013767 ATP binding site [chemical binding]; other site 426117013768 Q-loop/lid; other site 426117013769 ABC transporter signature motif; other site 426117013770 Walker B; other site 426117013771 D-loop; other site 426117013772 H-loop/switch region; other site 426117013773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117013774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426117013775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117013776 ABC-ATPase subunit interface; other site 426117013777 putative PBP binding loops; other site 426117013778 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426117013779 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117013780 Walker A/P-loop; other site 426117013781 ATP binding site [chemical binding]; other site 426117013782 Q-loop/lid; other site 426117013783 ABC transporter signature motif; other site 426117013784 Walker B; other site 426117013785 D-loop; other site 426117013786 H-loop/switch region; other site 426117013787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117013788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117013789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117013790 ABC-ATPase subunit interface; other site 426117013791 putative PBP binding loops; other site 426117013792 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117013793 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 426117013794 peptide binding site [polypeptide binding]; other site 426117013795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013796 dimerization interface [polypeptide binding]; other site 426117013797 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117013798 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117013799 metal binding site [ion binding]; metal-binding site 426117013800 active site 426117013801 I-site; other site 426117013802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117013803 Patatin-like phospholipase; Region: Patatin; pfam01734 426117013804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117013805 MarR family; Region: MarR; pfam01047 426117013806 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117013807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426117013808 putative active site [active] 426117013809 heme pocket [chemical binding]; other site 426117013810 PAS domain; Region: PAS_8; pfam13188 426117013811 PAS fold; Region: PAS_4; pfam08448 426117013812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117013814 dimer interface [polypeptide binding]; other site 426117013815 phosphorylation site [posttranslational modification] 426117013816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013817 ATP binding site [chemical binding]; other site 426117013818 Mg2+ binding site [ion binding]; other site 426117013819 G-X-G motif; other site 426117013820 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013822 active site 426117013823 phosphorylation site [posttranslational modification] 426117013824 intermolecular recognition site; other site 426117013825 dimerization interface [polypeptide binding]; other site 426117013826 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 426117013827 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 426117013828 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 426117013829 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 426117013830 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 426117013831 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 426117013832 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117013833 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117013834 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 426117013835 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 426117013836 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 426117013837 exopolyphosphatase; Region: exo_poly_only; TIGR03706 426117013838 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 426117013839 polyphosphate kinase; Provisional; Region: PRK05443 426117013840 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 426117013841 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 426117013842 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 426117013843 putative domain interface [polypeptide binding]; other site 426117013844 putative active site [active] 426117013845 catalytic site [active] 426117013846 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 426117013847 putative domain interface [polypeptide binding]; other site 426117013848 putative active site [active] 426117013849 catalytic site [active] 426117013850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426117013851 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 426117013852 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426117013853 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426117013854 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 426117013855 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 426117013856 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 426117013857 dimerization interface [polypeptide binding]; other site 426117013858 putative ATP binding site [chemical binding]; other site 426117013859 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 426117013860 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 426117013861 active site 426117013862 substrate binding site [chemical binding]; other site 426117013863 cosubstrate binding site; other site 426117013864 catalytic site [active] 426117013865 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 426117013866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117013867 inhibitor-cofactor binding pocket; inhibition site 426117013868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117013869 catalytic residue [active] 426117013870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117013871 MarR family; Region: MarR_2; pfam12802 426117013872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426117013873 Coenzyme A binding pocket [chemical binding]; other site 426117013874 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117013875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117013876 catalytic residue [active] 426117013877 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117013878 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 426117013879 AAA domain; Region: AAA_26; pfam13500 426117013880 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013882 active site 426117013883 phosphorylation site [posttranslational modification] 426117013884 intermolecular recognition site; other site 426117013885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117013886 putative active site [active] 426117013887 heme pocket [chemical binding]; other site 426117013888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013889 dimer interface [polypeptide binding]; other site 426117013890 phosphorylation site [posttranslational modification] 426117013891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013892 ATP binding site [chemical binding]; other site 426117013893 Mg2+ binding site [ion binding]; other site 426117013894 G-X-G motif; other site 426117013895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013896 active site 426117013897 phosphorylation site [posttranslational modification] 426117013898 intermolecular recognition site; other site 426117013899 dimerization interface [polypeptide binding]; other site 426117013900 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117013901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013902 dimerization interface [polypeptide binding]; other site 426117013903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013904 dimerization interface [polypeptide binding]; other site 426117013905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013906 dimerization interface [polypeptide binding]; other site 426117013907 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117013908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013909 dimerization interface [polypeptide binding]; other site 426117013910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013911 dimerization interface [polypeptide binding]; other site 426117013912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013913 dimerization interface [polypeptide binding]; other site 426117013914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013915 dimerization interface [polypeptide binding]; other site 426117013916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117013917 dimerization interface [polypeptide binding]; other site 426117013918 GAF domain; Region: GAF_2; pfam13185 426117013919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117013920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013921 dimer interface [polypeptide binding]; other site 426117013922 phosphorylation site [posttranslational modification] 426117013923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013924 ATP binding site [chemical binding]; other site 426117013925 Mg2+ binding site [ion binding]; other site 426117013926 G-X-G motif; other site 426117013927 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013929 active site 426117013930 phosphorylation site [posttranslational modification] 426117013931 intermolecular recognition site; other site 426117013932 dimerization interface [polypeptide binding]; other site 426117013933 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117013934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013935 active site 426117013936 phosphorylation site [posttranslational modification] 426117013937 intermolecular recognition site; other site 426117013938 dimerization interface [polypeptide binding]; other site 426117013939 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117013940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013941 active site 426117013942 phosphorylation site [posttranslational modification] 426117013943 intermolecular recognition site; other site 426117013944 dimerization interface [polypeptide binding]; other site 426117013945 Response regulator receiver domain; Region: Response_reg; pfam00072 426117013946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117013947 active site 426117013948 phosphorylation site [posttranslational modification] 426117013949 intermolecular recognition site; other site 426117013950 dimerization interface [polypeptide binding]; other site 426117013951 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117013952 circadian clock protein KaiC; Reviewed; Region: PRK09302 426117013953 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117013954 Walker A motif; other site 426117013955 Walker A motif; other site 426117013956 ATP binding site [chemical binding]; other site 426117013957 ATP binding site [chemical binding]; other site 426117013958 Walker B motif; other site 426117013959 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117013960 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117013961 Walker A motif; other site 426117013962 Walker A motif; other site 426117013963 ATP binding site [chemical binding]; other site 426117013964 Walker B motif; other site 426117013965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117013966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117013967 dimer interface [polypeptide binding]; other site 426117013968 phosphorylation site [posttranslational modification] 426117013969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117013970 ATP binding site [chemical binding]; other site 426117013971 Mg2+ binding site [ion binding]; other site 426117013972 G-X-G motif; other site 426117013973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117013974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117013975 metal binding site [ion binding]; metal-binding site 426117013976 active site 426117013977 I-site; other site 426117013978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117013979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117013980 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117013981 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 426117013982 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 426117013983 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 426117013984 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117013985 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 426117013986 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 426117013987 Substrate binding site; other site 426117013988 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 426117013989 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 426117013990 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 426117013991 active site 426117013992 substrate binding site [chemical binding]; other site 426117013993 metal binding site [ion binding]; metal-binding site 426117013994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117013995 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 426117013996 NAD(P) binding site [chemical binding]; other site 426117013997 active site 426117013998 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 426117013999 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 426117014000 NADP-binding site; other site 426117014001 homotetramer interface [polypeptide binding]; other site 426117014002 substrate binding site [chemical binding]; other site 426117014003 homodimer interface [polypeptide binding]; other site 426117014004 active site 426117014005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117014006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117014007 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 426117014008 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426117014009 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426117014010 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 426117014011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117014012 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117014013 active site 426117014014 metal binding site [ion binding]; metal-binding site 426117014015 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117014016 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 426117014017 dimer interaction site [polypeptide binding]; other site 426117014018 substrate-binding tunnel; other site 426117014019 active site 426117014020 catalytic site [active] 426117014021 substrate binding site [chemical binding]; other site 426117014022 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426117014023 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 426117014024 phytoene desaturase; Region: crtI_fam; TIGR02734 426117014025 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117014026 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 426117014027 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426117014028 putative active site [active] 426117014029 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 426117014030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 426117014031 N-formylglutamate amidohydrolase; Region: FGase; cl01522 426117014032 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117014033 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117014034 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 426117014035 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 426117014036 MOFRL family; Region: MOFRL; pfam05161 426117014037 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 426117014038 pyruvate kinase; Provisional; Region: PRK06247 426117014039 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426117014040 domain interfaces; other site 426117014041 active site 426117014042 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426117014043 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 426117014044 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426117014045 catalytic site [active] 426117014046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117014047 TPR motif; other site 426117014048 binding surface 426117014049 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 426117014050 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 426117014051 heme-binding site [chemical binding]; other site 426117014052 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117014053 dimer interface [polypeptide binding]; other site 426117014054 putative CheW interface [polypeptide binding]; other site 426117014055 Predicted membrane protein [Function unknown]; Region: COG1238 426117014056 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 426117014057 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 426117014058 nitrilase; Region: PLN02798 426117014059 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 426117014060 putative active site [active] 426117014061 catalytic triad [active] 426117014062 dimer interface [polypeptide binding]; other site 426117014063 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 426117014064 GSH binding site [chemical binding]; other site 426117014065 catalytic residues [active] 426117014066 Response regulator receiver domain; Region: Response_reg; pfam00072 426117014067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117014068 active site 426117014069 phosphorylation site [posttranslational modification] 426117014070 intermolecular recognition site; other site 426117014071 dimerization interface [polypeptide binding]; other site 426117014072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117014073 active site 426117014074 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 426117014075 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426117014076 DctM-like transporters; Region: DctM; pfam06808 426117014077 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 426117014078 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 426117014079 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117014080 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426117014081 Uncharacterized conserved protein [Function unknown]; Region: COG3777 426117014082 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 426117014083 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 426117014084 active site 2 [active] 426117014085 active site 1 [active] 426117014086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426117014087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426117014088 active site 426117014089 putative CoA-transferase; Provisional; Region: PRK11430 426117014090 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426117014091 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 426117014092 elongation factor G; Reviewed; Region: PRK12740 426117014093 G1 box; other site 426117014094 putative GEF interaction site [polypeptide binding]; other site 426117014095 GTP/Mg2+ binding site [chemical binding]; other site 426117014096 Switch I region; other site 426117014097 G2 box; other site 426117014098 G3 box; other site 426117014099 Switch II region; other site 426117014100 G4 box; other site 426117014101 G5 box; other site 426117014102 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 426117014103 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 426117014104 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 426117014105 Phasin protein; Region: Phasin_2; cl11491 426117014106 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 426117014107 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426117014108 Cl- selectivity filter; other site 426117014109 Cl- binding residues [ion binding]; other site 426117014110 pore gating glutamate residue; other site 426117014111 dimer interface [polypeptide binding]; other site 426117014112 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426117014113 tartrate dehydrogenase; Region: TTC; TIGR02089 426117014114 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 426117014115 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 426117014116 RNA/DNA hybrid binding site [nucleotide binding]; other site 426117014117 active site 426117014118 xanthine permease; Region: pbuX; TIGR03173 426117014119 urate oxidase; Region: urate_oxi; TIGR03383 426117014120 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 426117014121 active site 426117014122 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 426117014123 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 426117014124 active site 426117014125 homotetramer interface [polypeptide binding]; other site 426117014126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117014127 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 426117014128 active site 426117014129 dimer interface [polypeptide binding]; other site 426117014130 metal binding site [ion binding]; metal-binding site 426117014131 glutathione binding site [chemical binding]; other site 426117014132 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 426117014133 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426117014134 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426117014135 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 426117014136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117014137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117014138 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426117014139 dimerization interface [polypeptide binding]; other site 426117014140 Ribbon-helix-helix domain; Region: RHH_4; cl01775 426117014141 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 426117014142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117014143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117014144 homodimer interface [polypeptide binding]; other site 426117014145 catalytic residue [active] 426117014146 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 426117014147 prephenate dehydrogenase; Validated; Region: PRK08507 426117014148 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426117014149 nucleophile elbow; other site 426117014150 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 426117014151 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 426117014152 dimer interface [polypeptide binding]; other site 426117014153 TPP-binding site [chemical binding]; other site 426117014154 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 426117014155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117014156 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426117014157 E3 interaction surface; other site 426117014158 lipoyl attachment site [posttranslational modification]; other site 426117014159 e3 binding domain; Region: E3_binding; pfam02817 426117014160 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426117014161 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 426117014162 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117014163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117014164 putative substrate translocation pore; other site 426117014165 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 426117014166 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 426117014167 putative active site [active] 426117014168 putative dimer interface [polypeptide binding]; other site 426117014169 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 426117014170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117014171 Zn2+ binding site [ion binding]; other site 426117014172 Mg2+ binding site [ion binding]; other site 426117014173 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117014174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117014175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117014176 DNA binding residues [nucleotide binding] 426117014177 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426117014178 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 426117014179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117014180 S-adenosylmethionine binding site [chemical binding]; other site 426117014181 OstA-like protein; Region: OstA; cl00844 426117014182 OstA-like protein; Region: OstA; cl00844 426117014183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 426117014184 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 426117014185 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 426117014186 catalytic site [active] 426117014187 putative active site [active] 426117014188 putative substrate binding site [chemical binding]; other site 426117014189 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 426117014190 Helix-hairpin-helix motif; Region: HHH; pfam00633 426117014191 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 426117014192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 426117014193 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 426117014194 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 426117014195 putative acyltransferase; Provisional; Region: PRK05790 426117014196 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426117014197 dimer interface [polypeptide binding]; other site 426117014198 active site 426117014199 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 426117014200 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 426117014201 NAD(P) binding site [chemical binding]; other site 426117014202 homotetramer interface [polypeptide binding]; other site 426117014203 homodimer interface [polypeptide binding]; other site 426117014204 active site 426117014205 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426117014206 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 426117014207 FAD binding pocket [chemical binding]; other site 426117014208 FAD binding motif [chemical binding]; other site 426117014209 phosphate binding motif [ion binding]; other site 426117014210 beta-alpha-beta structure motif; other site 426117014211 NAD binding pocket [chemical binding]; other site 426117014212 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426117014213 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 426117014214 Peptidase family M48; Region: Peptidase_M48; pfam01435 426117014215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426117014216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117014217 non-specific DNA binding site [nucleotide binding]; other site 426117014218 salt bridge; other site 426117014219 sequence-specific DNA binding site [nucleotide binding]; other site 426117014220 S-adenosylmethionine synthetase; Validated; Region: PRK05250 426117014221 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 426117014222 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 426117014223 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 426117014224 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 426117014225 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117014226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117014227 putative active site [active] 426117014228 heme pocket [chemical binding]; other site 426117014229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117014230 putative active site [active] 426117014231 heme pocket [chemical binding]; other site 426117014232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117014233 HWE histidine kinase; Region: HWE_HK; pfam07536 426117014234 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117014235 Response regulator receiver domain; Region: Response_reg; pfam00072 426117014236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117014237 active site 426117014238 phosphorylation site [posttranslational modification] 426117014239 intermolecular recognition site; other site 426117014240 dimerization interface [polypeptide binding]; other site 426117014241 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117014242 cyclase homology domain; Region: CHD; cd07302 426117014243 nucleotidyl binding site; other site 426117014244 metal binding site [ion binding]; metal-binding site 426117014245 dimer interface [polypeptide binding]; other site 426117014246 Response regulator receiver domain; Region: Response_reg; pfam00072 426117014247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117014248 active site 426117014249 phosphorylation site [posttranslational modification] 426117014250 intermolecular recognition site; other site 426117014251 dimerization interface [polypeptide binding]; other site 426117014252 Cache domain; Region: Cache_1; pfam02743 426117014253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117014254 dimerization interface [polypeptide binding]; other site 426117014255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117014256 GAF domain; Region: GAF; pfam01590 426117014257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117014258 dimer interface [polypeptide binding]; other site 426117014259 phosphorylation site [posttranslational modification] 426117014260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117014261 ATP binding site [chemical binding]; other site 426117014262 Mg2+ binding site [ion binding]; other site 426117014263 G-X-G motif; other site 426117014264 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426117014265 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426117014266 active site 426117014267 non-prolyl cis peptide bond; other site 426117014268 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 426117014269 dimer interface [polypeptide binding]; other site 426117014270 FMN binding site [chemical binding]; other site 426117014271 NADPH bind site [chemical binding]; other site 426117014272 Rrf2 family protein; Region: rrf2_super; TIGR00738 426117014273 Transcriptional regulator; Region: Rrf2; pfam02082 426117014274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 426117014275 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 426117014276 MviN-like protein; Region: MVIN; pfam03023 426117014277 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 426117014278 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 426117014279 Ligand binding site; other site 426117014280 Putative Catalytic site; other site 426117014281 DXD motif; other site 426117014282 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 426117014283 putative active site [active] 426117014284 YdjC motif; other site 426117014285 Mg binding site [ion binding]; other site 426117014286 putative homodimer interface [polypeptide binding]; other site 426117014287 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 426117014288 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 426117014289 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 426117014290 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426117014291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117014292 motif II; other site 426117014293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 426117014294 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 426117014295 lipoate-protein ligase B; Provisional; Region: PRK14341 426117014296 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 426117014297 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 426117014298 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 426117014299 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 426117014300 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 426117014301 putative tRNA-binding site [nucleotide binding]; other site 426117014302 B3/4 domain; Region: B3_4; pfam03483 426117014303 tRNA synthetase B5 domain; Region: B5; smart00874 426117014304 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 426117014305 dimer interface [polypeptide binding]; other site 426117014306 motif 1; other site 426117014307 motif 3; other site 426117014308 motif 2; other site 426117014309 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 426117014310 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 426117014311 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 426117014312 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 426117014313 dimer interface [polypeptide binding]; other site 426117014314 motif 1; other site 426117014315 active site 426117014316 motif 2; other site 426117014317 motif 3; other site 426117014318 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 426117014319 23S rRNA binding site [nucleotide binding]; other site 426117014320 L21 binding site [polypeptide binding]; other site 426117014321 L13 binding site [polypeptide binding]; other site 426117014322 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 426117014323 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 426117014324 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117014325 putative ADP-binding pocket [chemical binding]; other site 426117014326 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 426117014327 Protein of unknown function, DUF608; Region: DUF608; pfam04685 426117014328 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 426117014329 homodimer interaction site [polypeptide binding]; other site 426117014330 cofactor binding site; other site 426117014331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117014332 dimer interface [polypeptide binding]; other site 426117014333 putative CheW interface [polypeptide binding]; other site 426117014334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426117014335 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117014336 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 426117014337 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 426117014338 acyl-activating enzyme (AAE) consensus motif; other site 426117014339 AMP binding site [chemical binding]; other site 426117014340 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426117014341 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 426117014342 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 426117014343 putative trimer interface [polypeptide binding]; other site 426117014344 putative CoA binding site [chemical binding]; other site 426117014345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117014346 catalytic core [active] 426117014347 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 426117014348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117014349 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 426117014350 active site 426117014351 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 426117014352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117014353 Mg2+ binding site [ion binding]; other site 426117014354 G-X-G motif; other site 426117014355 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426117014356 anchoring element; other site 426117014357 dimer interface [polypeptide binding]; other site 426117014358 ATP binding site [chemical binding]; other site 426117014359 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 426117014360 active site 426117014361 putative metal-binding site [ion binding]; other site 426117014362 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426117014363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117014364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117014365 active site 426117014366 catalytic tetrad [active] 426117014367 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426117014368 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 426117014369 Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142 426117014370 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 426117014371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117014372 Transglycosylase; Region: Transgly; pfam00912 426117014373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426117014374 Domain of unknown function (DUF336); Region: DUF336; cl01249 426117014375 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 426117014376 peptide binding site [polypeptide binding]; other site 426117014377 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426117014378 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 426117014379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014380 dimer interface [polypeptide binding]; other site 426117014381 conserved gate region; other site 426117014382 putative PBP binding loops; other site 426117014383 ABC-ATPase subunit interface; other site 426117014384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014385 dimer interface [polypeptide binding]; other site 426117014386 conserved gate region; other site 426117014387 ABC-ATPase subunit interface; other site 426117014388 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 426117014389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117014390 Walker A/P-loop; other site 426117014391 ATP binding site [chemical binding]; other site 426117014392 Q-loop/lid; other site 426117014393 ABC transporter signature motif; other site 426117014394 Walker B; other site 426117014395 D-loop; other site 426117014396 H-loop/switch region; other site 426117014397 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117014398 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117014399 Q-loop/lid; other site 426117014400 ABC transporter signature motif; other site 426117014401 Walker B; other site 426117014402 D-loop; other site 426117014403 H-loop/switch region; other site 426117014404 Predicted integral membrane protein [Function unknown]; Region: COG5473 426117014405 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426117014406 Beta-lactamase; Region: Beta-lactamase; pfam00144 426117014407 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 426117014408 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 426117014409 FMN binding site [chemical binding]; other site 426117014410 substrate binding site [chemical binding]; other site 426117014411 putative catalytic residue [active] 426117014412 SnoaL-like domain; Region: SnoaL_2; pfam12680 426117014413 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 426117014414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117014415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117014416 dimerization interface [polypeptide binding]; other site 426117014417 LysE type translocator; Region: LysE; cl00565 426117014418 allantoate amidohydrolase; Reviewed; Region: PRK12893 426117014419 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426117014420 active site 426117014421 metal binding site [ion binding]; metal-binding site 426117014422 dimer interface [polypeptide binding]; other site 426117014423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117014424 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 426117014425 ATP-NAD kinase; Region: NAD_kinase; pfam01513 426117014426 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 426117014427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117014428 dimerization interface [polypeptide binding]; other site 426117014429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117014430 dimer interface [polypeptide binding]; other site 426117014431 phosphorylation site [posttranslational modification] 426117014432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117014433 ATP binding site [chemical binding]; other site 426117014434 Mg2+ binding site [ion binding]; other site 426117014435 G-X-G motif; other site 426117014436 Response regulator receiver domain; Region: Response_reg; pfam00072 426117014437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117014438 active site 426117014439 phosphorylation site [posttranslational modification] 426117014440 intermolecular recognition site; other site 426117014441 dimerization interface [polypeptide binding]; other site 426117014442 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 426117014443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117014444 active site 426117014445 phosphorylation site [posttranslational modification] 426117014446 intermolecular recognition site; other site 426117014447 dimerization interface [polypeptide binding]; other site 426117014448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117014449 Zn2+ binding site [ion binding]; other site 426117014450 Mg2+ binding site [ion binding]; other site 426117014451 Protein of unknown function, DUF488; Region: DUF488; pfam04343 426117014452 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 426117014453 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 426117014454 active site 426117014455 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 426117014456 RNA/DNA hybrid binding site [nucleotide binding]; other site 426117014457 active site 426117014458 acyl-CoA synthetase; Validated; Region: PRK07470 426117014459 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 426117014460 acyl-activating enzyme (AAE) consensus motif; other site 426117014461 putative AMP binding site [chemical binding]; other site 426117014462 putative active site [active] 426117014463 putative CoA binding site [chemical binding]; other site 426117014464 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 426117014465 trimer interface [polypeptide binding]; other site 426117014466 putative Zn binding site [ion binding]; other site 426117014467 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 426117014468 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 426117014469 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 426117014470 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 426117014471 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 426117014472 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117014473 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 426117014474 putative active site [active] 426117014475 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 426117014476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426117014477 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 426117014478 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 426117014479 dimer interface [polypeptide binding]; other site 426117014480 active site 426117014481 glycine-pyridoxal phosphate binding site [chemical binding]; other site 426117014482 folate binding site [chemical binding]; other site 426117014483 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 426117014484 ParB-like nuclease domain; Region: ParB; smart00470 426117014485 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 426117014486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117014487 P-loop; other site 426117014488 Magnesium ion binding site [ion binding]; other site 426117014489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117014490 Magnesium ion binding site [ion binding]; other site 426117014491 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117014492 active site 426117014493 metal binding site [ion binding]; metal-binding site 426117014494 BA14K-like protein; Region: BA14K; pfam07886 426117014495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 426117014496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 426117014497 CsbD-like; Region: CsbD; pfam05532 426117014498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426117014499 metal binding site 2 [ion binding]; metal-binding site 426117014500 putative DNA binding helix; other site 426117014501 metal binding site 1 [ion binding]; metal-binding site 426117014502 dimer interface [polypeptide binding]; other site 426117014503 structural Zn2+ binding site [ion binding]; other site 426117014504 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 426117014505 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 426117014506 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 426117014507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426117014508 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117014509 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426117014510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117014511 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117014512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117014513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117014514 DNA binding residues [nucleotide binding] 426117014515 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 426117014516 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426117014517 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426117014518 dimer interface [polypeptide binding]; other site 426117014519 putative functional site; other site 426117014520 putative MPT binding site; other site 426117014521 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 426117014522 trimer interface [polypeptide binding]; other site 426117014523 dimer interface [polypeptide binding]; other site 426117014524 putative active site [active] 426117014525 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 426117014526 active site 426117014527 ribulose/triose binding site [chemical binding]; other site 426117014528 phosphate binding site [ion binding]; other site 426117014529 substrate (anthranilate) binding pocket [chemical binding]; other site 426117014530 product (indole) binding pocket [chemical binding]; other site 426117014531 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 426117014532 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 426117014533 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 426117014534 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426117014535 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 426117014536 glutamine binding [chemical binding]; other site 426117014537 catalytic triad [active] 426117014538 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 426117014539 anthranilate synthase component I; Provisional; Region: PRK13573 426117014540 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 426117014541 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 426117014542 SurA N-terminal domain; Region: SurA_N_3; cl07813 426117014543 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 426117014544 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 426117014545 triosephosphate isomerase; Provisional; Region: PRK14565 426117014546 substrate binding site [chemical binding]; other site 426117014547 dimer interface [polypeptide binding]; other site 426117014548 catalytic triad [active] 426117014549 CTP synthetase; Validated; Region: pyrG; PRK05380 426117014550 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 426117014551 Catalytic site [active] 426117014552 active site 426117014553 UTP binding site [chemical binding]; other site 426117014554 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 426117014555 active site 426117014556 putative oxyanion hole; other site 426117014557 catalytic triad [active] 426117014558 Predicted membrane protein [Function unknown]; Region: COG3766 426117014559 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 426117014560 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 426117014561 DNA polymerase III subunit chi; Validated; Region: PRK05728 426117014562 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 426117014563 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 426117014564 OpgC protein; Region: OpgC_C; pfam10129 426117014565 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426117014566 oxyanion hole [active] 426117014567 biotin synthase; Region: bioB; TIGR00433 426117014568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117014569 FeS/SAM binding site; other site 426117014570 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 426117014571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117014572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117014573 dimerization interface [polypeptide binding]; other site 426117014574 PAS domain; Region: PAS_9; pfam13426 426117014575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117014576 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 426117014577 DNA binding residues [nucleotide binding] 426117014578 dimerization interface [polypeptide binding]; other site 426117014579 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 426117014580 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 426117014581 MPT binding site; other site 426117014582 trimer interface [polypeptide binding]; other site 426117014583 Predicted metalloprotease [General function prediction only]; Region: COG2321 426117014584 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 426117014585 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 426117014586 Fe-S cluster binding site [ion binding]; other site 426117014587 active site 426117014588 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 426117014589 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 426117014590 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 426117014591 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117014592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117014593 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117014594 substrate binding pocket [chemical binding]; other site 426117014595 membrane-bound complex binding site; other site 426117014596 hinge residues; other site 426117014597 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 426117014598 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 426117014599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426117014600 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426117014601 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426117014602 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 426117014603 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426117014604 carboxyltransferase (CT) interaction site; other site 426117014605 biotinylation site [posttranslational modification]; other site 426117014606 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 426117014607 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426117014608 catalytic residues [active] 426117014609 hypothetical protein; Provisional; Region: PRK08960 426117014610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117014611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117014612 homodimer interface [polypeptide binding]; other site 426117014613 catalytic residue [active] 426117014614 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 426117014615 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 426117014616 substrate binding site [chemical binding]; other site 426117014617 hexamer interface [polypeptide binding]; other site 426117014618 metal binding site [ion binding]; metal-binding site 426117014619 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 426117014620 rRNA binding site [nucleotide binding]; other site 426117014621 predicted 30S ribosome binding site; other site 426117014622 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117014623 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 426117014624 dimerization interface [polypeptide binding]; other site 426117014625 ligand binding site [chemical binding]; other site 426117014626 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117014627 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117014628 Walker A/P-loop; other site 426117014629 ATP binding site [chemical binding]; other site 426117014630 Q-loop/lid; other site 426117014631 ABC transporter signature motif; other site 426117014632 Walker B; other site 426117014633 D-loop; other site 426117014634 H-loop/switch region; other site 426117014635 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 426117014636 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117014637 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117014638 Walker A/P-loop; other site 426117014639 ATP binding site [chemical binding]; other site 426117014640 Q-loop/lid; other site 426117014641 ABC transporter signature motif; other site 426117014642 Walker B; other site 426117014643 D-loop; other site 426117014644 H-loop/switch region; other site 426117014645 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 426117014646 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117014647 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117014648 TM-ABC transporter signature motif; other site 426117014649 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117014650 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117014651 TM-ABC transporter signature motif; other site 426117014652 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 426117014653 putative hydrophobic ligand binding site [chemical binding]; other site 426117014654 Protein of unknown function (DUF707); Region: DUF707; pfam05212 426117014655 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 426117014656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117014657 UDP-galactopyranose mutase; Region: GLF; pfam03275 426117014658 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117014659 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117014660 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117014661 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117014662 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117014663 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426117014664 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426117014665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117014666 non-specific DNA binding site [nucleotide binding]; other site 426117014667 salt bridge; other site 426117014668 sequence-specific DNA binding site [nucleotide binding]; other site 426117014669 MoxR-like ATPases [General function prediction only]; Region: COG0714 426117014670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117014671 Walker A motif; other site 426117014672 ATP binding site [chemical binding]; other site 426117014673 Walker B motif; other site 426117014674 arginine finger; other site 426117014675 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 426117014676 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 426117014677 metal ion-dependent adhesion site (MIDAS); other site 426117014678 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 426117014679 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 426117014680 XdhC Rossmann domain; Region: XdhC_C; pfam13478 426117014681 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 426117014682 MPT binding site; other site 426117014683 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 426117014684 Ligand binding site; other site 426117014685 metal-binding site 426117014686 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 426117014687 Usg-like family; Region: Usg; pfam06233 426117014688 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 426117014689 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 426117014690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117014691 NAD(P) binding site [chemical binding]; other site 426117014692 active site 426117014693 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 426117014694 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 426117014695 active site 426117014696 cosubstrate binding site; other site 426117014697 substrate binding site [chemical binding]; other site 426117014698 catalytic site [active] 426117014699 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 426117014700 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 426117014701 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 426117014702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117014703 metal binding site [ion binding]; metal-binding site 426117014704 active site 426117014705 I-site; other site 426117014706 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117014707 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426117014708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117014709 putative substrate translocation pore; other site 426117014710 Autoinducer synthetase; Region: Autoind_synth; cl17404 426117014711 Autoinducer binding domain; Region: Autoind_bind; pfam03472 426117014712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117014713 DNA binding residues [nucleotide binding] 426117014714 dimerization interface [polypeptide binding]; other site 426117014715 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 426117014716 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 426117014717 ring oligomerisation interface [polypeptide binding]; other site 426117014718 ATP/Mg binding site [chemical binding]; other site 426117014719 stacking interactions; other site 426117014720 hinge regions; other site 426117014721 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 426117014722 oligomerisation interface [polypeptide binding]; other site 426117014723 mobile loop; other site 426117014724 roof hairpin; other site 426117014725 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117014726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117014727 substrate binding pocket [chemical binding]; other site 426117014728 membrane-bound complex binding site; other site 426117014729 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 426117014730 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 426117014731 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 426117014732 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 426117014733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117014734 Walker A/P-loop; other site 426117014735 ATP binding site [chemical binding]; other site 426117014736 Q-loop/lid; other site 426117014737 ABC transporter signature motif; other site 426117014738 Walker B; other site 426117014739 D-loop; other site 426117014740 H-loop/switch region; other site 426117014741 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 426117014742 active site 426117014743 catalytic triad [active] 426117014744 oxyanion hole [active] 426117014745 switch loop; other site 426117014746 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 426117014747 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 426117014748 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 426117014749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117014750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117014751 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426117014752 catalytic residues [active] 426117014753 dimer interface [polypeptide binding]; other site 426117014754 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 426117014755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117014756 Walker A/P-loop; other site 426117014757 ATP binding site [chemical binding]; other site 426117014758 Q-loop/lid; other site 426117014759 ABC transporter signature motif; other site 426117014760 Walker B; other site 426117014761 D-loop; other site 426117014762 H-loop/switch region; other site 426117014763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014764 dimer interface [polypeptide binding]; other site 426117014765 conserved gate region; other site 426117014766 putative PBP binding loops; other site 426117014767 ABC-ATPase subunit interface; other site 426117014768 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426117014769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014770 dimer interface [polypeptide binding]; other site 426117014771 conserved gate region; other site 426117014772 putative PBP binding loops; other site 426117014773 ABC-ATPase subunit interface; other site 426117014774 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 426117014775 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 426117014776 CysD dimerization site [polypeptide binding]; other site 426117014777 G1 box; other site 426117014778 putative GEF interaction site [polypeptide binding]; other site 426117014779 GTP/Mg2+ binding site [chemical binding]; other site 426117014780 Switch I region; other site 426117014781 G2 box; other site 426117014782 G3 box; other site 426117014783 Switch II region; other site 426117014784 G4 box; other site 426117014785 G5 box; other site 426117014786 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 426117014787 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 426117014788 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 426117014789 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426117014790 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 426117014791 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 426117014792 Active Sites [active] 426117014793 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 426117014794 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 426117014795 Active Sites [active] 426117014796 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426117014797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426117014798 putative DNA binding site [nucleotide binding]; other site 426117014799 putative Zn2+ binding site [ion binding]; other site 426117014800 AsnC family; Region: AsnC_trans_reg; pfam01037 426117014801 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 426117014802 Flavodoxin; Region: Flavodoxin_1; pfam00258 426117014803 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 426117014804 FAD binding pocket [chemical binding]; other site 426117014805 FAD binding motif [chemical binding]; other site 426117014806 catalytic residues [active] 426117014807 NAD binding pocket [chemical binding]; other site 426117014808 phosphate binding motif [ion binding]; other site 426117014809 beta-alpha-beta structure motif; other site 426117014810 sulfite reductase subunit beta; Provisional; Region: PRK13504 426117014811 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426117014812 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426117014813 aminotransferase; Provisional; Region: PRK13356 426117014814 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426117014815 homodimer interface [polypeptide binding]; other site 426117014816 substrate-cofactor binding pocket; other site 426117014817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117014818 catalytic residue [active] 426117014819 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 426117014820 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426117014821 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117014822 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426117014823 DNA-binding site [nucleotide binding]; DNA binding site 426117014824 RNA-binding motif; other site 426117014825 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 426117014826 intracellular protease, PfpI family; Region: PfpI; TIGR01382 426117014827 proposed catalytic triad [active] 426117014828 conserved cys residue [active] 426117014829 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 426117014830 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 426117014831 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426117014832 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 426117014833 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 426117014834 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 426117014835 Nitrogen regulatory protein P-II; Region: P-II; smart00938 426117014836 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 426117014837 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 426117014838 active site 426117014839 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 426117014840 catalytic triad [active] 426117014841 dimer interface [polypeptide binding]; other site 426117014842 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117014843 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 426117014844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426117014845 Ligand binding site; other site 426117014846 DXD motif; other site 426117014847 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 426117014848 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426117014849 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 426117014850 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117014851 active site 426117014852 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 426117014853 active site 426117014854 substrate binding site [chemical binding]; other site 426117014855 CoA binding site [chemical binding]; other site 426117014856 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 426117014857 RNA polymerase sigma-W factor; Region: SigW_bacill; TIGR02948 426117014858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 426117014859 Anti-sigma-K factor rskA; Region: RskA; pfam10099 426117014860 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 426117014861 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 426117014862 glutaminase active site [active] 426117014863 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 426117014864 dimer interface [polypeptide binding]; other site 426117014865 active site 426117014866 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 426117014867 dimer interface [polypeptide binding]; other site 426117014868 active site 426117014869 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426117014870 PAS domain; Region: PAS_9; pfam13426 426117014871 PAS domain; Region: PAS_9; pfam13426 426117014872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117014873 putative active site [active] 426117014874 heme pocket [chemical binding]; other site 426117014875 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117014876 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117014877 dimer interface [polypeptide binding]; other site 426117014878 putative CheW interface [polypeptide binding]; other site 426117014879 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426117014880 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 426117014881 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 426117014882 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 426117014883 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 426117014884 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 426117014885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117014886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117014887 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 426117014888 putative dimerization interface [polypeptide binding]; other site 426117014889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117014890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117014891 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117014892 substrate binding pocket [chemical binding]; other site 426117014893 membrane-bound complex binding site; other site 426117014894 hinge residues; other site 426117014895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014896 dimer interface [polypeptide binding]; other site 426117014897 conserved gate region; other site 426117014898 putative PBP binding loops; other site 426117014899 ABC-ATPase subunit interface; other site 426117014900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117014901 dimer interface [polypeptide binding]; other site 426117014902 conserved gate region; other site 426117014903 ABC-ATPase subunit interface; other site 426117014904 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117014905 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117014906 Walker A/P-loop; other site 426117014907 ATP binding site [chemical binding]; other site 426117014908 Q-loop/lid; other site 426117014909 ABC transporter signature motif; other site 426117014910 Walker B; other site 426117014911 D-loop; other site 426117014912 H-loop/switch region; other site 426117014913 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 426117014914 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 426117014915 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 426117014916 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 426117014917 putative active site [active] 426117014918 putative FMN binding site [chemical binding]; other site 426117014919 putative catalytic residue [active] 426117014920 putative substrate binding site [chemical binding]; other site 426117014921 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 426117014922 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426117014923 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426117014924 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 426117014925 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 426117014926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117014927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117014928 dimerization interface [polypeptide binding]; other site 426117014929 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117014930 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117014931 putative ligand binding site [chemical binding]; other site 426117014932 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 426117014933 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 426117014934 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117014935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117014936 Walker A motif; other site 426117014937 ATP binding site [chemical binding]; other site 426117014938 Walker B motif; other site 426117014939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117014940 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117014941 Integrase core domain; Region: rve; pfam00665 426117014942 short chain dehydrogenase; Provisional; Region: PRK12829 426117014943 classical (c) SDRs; Region: SDR_c; cd05233 426117014944 NAD(P) binding site [chemical binding]; other site 426117014945 active site 426117014946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117014947 D-galactonate transporter; Region: 2A0114; TIGR00893 426117014948 putative substrate translocation pore; other site 426117014949 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426117014950 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 426117014951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426117014952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117014953 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 426117014954 active site 426117014955 DNA binding site [nucleotide binding] 426117014956 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 426117014957 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 426117014958 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 426117014959 AAA domain; Region: AAA_30; pfam13604 426117014960 Family description; Region: UvrD_C_2; pfam13538 426117014961 Cupin domain; Region: Cupin_2; pfam07883 426117014962 Transposase domain (DUF772); Region: DUF772; pfam05598 426117014963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117014964 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117014965 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117014966 Transposase domain (DUF772); Region: DUF772; pfam05598 426117014967 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 426117014968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117014969 PAS domain; Region: PAS_9; pfam13426 426117014970 putative active site [active] 426117014971 heme pocket [chemical binding]; other site 426117014972 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 426117014973 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426117014974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117014975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117014976 catalytic residue [active] 426117014977 Sporulation related domain; Region: SPOR; pfam05036 426117014978 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117014979 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117014980 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 426117014981 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 426117014982 Cl binding site [ion binding]; other site 426117014983 oligomer interface [polypeptide binding]; other site 426117014984 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426117014985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 426117014986 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 426117014987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117014988 DNA-binding site [nucleotide binding]; DNA binding site 426117014989 FCD domain; Region: FCD; pfam07729 426117014990 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117014991 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117014992 putative ligand binding site [chemical binding]; other site 426117014993 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117014994 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 426117014995 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 426117014996 iron-sulfur cluster [ion binding]; other site 426117014997 [2Fe-2S] cluster binding site [ion binding]; other site 426117014998 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 426117014999 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 426117015000 ring oligomerisation interface [polypeptide binding]; other site 426117015001 ATP/Mg binding site [chemical binding]; other site 426117015002 stacking interactions; other site 426117015003 hinge regions; other site 426117015004 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 426117015005 oligomerisation interface [polypeptide binding]; other site 426117015006 mobile loop; other site 426117015007 roof hairpin; other site 426117015008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015009 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426117015010 putative active site [active] 426117015011 heme pocket [chemical binding]; other site 426117015012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015013 putative active site [active] 426117015014 heme pocket [chemical binding]; other site 426117015015 PAS fold; Region: PAS_3; pfam08447 426117015016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015017 putative active site [active] 426117015018 heme pocket [chemical binding]; other site 426117015019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117015020 HWE histidine kinase; Region: HWE_HK; pfam07536 426117015021 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117015022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426117015023 active site 426117015024 phosphorylation site [posttranslational modification] 426117015025 intermolecular recognition site; other site 426117015026 dimerization interface [polypeptide binding]; other site 426117015027 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117015028 GAF domain; Region: GAF; pfam01590 426117015029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117015030 HWE histidine kinase; Region: HWE_HK; pfam07536 426117015031 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117015032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117015033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117015034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015035 ATP binding site [chemical binding]; other site 426117015036 Mg2+ binding site [ion binding]; other site 426117015037 G-X-G motif; other site 426117015038 Homeodomain-like domain; Region: HTH_23; pfam13384 426117015039 Winged helix-turn helix; Region: HTH_29; pfam13551 426117015040 Homeodomain-like domain; Region: HTH_32; pfam13565 426117015041 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117015042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 426117015043 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117015044 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117015045 Integrase core domain; Region: rve; pfam00665 426117015046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117015047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015048 ATP binding site [chemical binding]; other site 426117015049 Mg2+ binding site [ion binding]; other site 426117015050 G-X-G motif; other site 426117015051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 426117015052 Transposase; Region: DEDD_Tnp_IS110; pfam01548 426117015053 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 426117015054 Winged helix-turn helix; Region: HTH_29; pfam13551 426117015055 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117015056 Homeodomain-like domain; Region: HTH_32; pfam13565 426117015057 Integrase core domain; Region: rve; pfam00665 426117015058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 426117015059 Integrase core domain; Region: rve_3; pfam13683 426117015060 HTH-like domain; Region: HTH_21; pfam13276 426117015061 Transposase; Region: HTH_Tnp_1; cl17663 426117015062 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 426117015063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117015064 catalytic site [active] 426117015065 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426117015066 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117015067 GAF domain; Region: GAF; pfam01590 426117015068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117015069 HWE histidine kinase; Region: HWE_HK; pfam07536 426117015070 response regulator; Provisional; Region: PRK13435 426117015071 PRC-barrel domain; Region: PRC; pfam05239 426117015072 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 426117015073 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426117015074 potential catalytic triad [active] 426117015075 conserved cys residue [active] 426117015076 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426117015077 inhibitor site; inhibition site 426117015078 active site 426117015079 dimer interface [polypeptide binding]; other site 426117015080 catalytic residue [active] 426117015081 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 426117015082 active site 1 [active] 426117015083 dimer interface [polypeptide binding]; other site 426117015084 hexamer interface [polypeptide binding]; other site 426117015085 active site 2 [active] 426117015086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117015087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117015088 DNA binding site [nucleotide binding] 426117015089 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117015090 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 426117015091 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 426117015092 Citrate transporter; Region: CitMHS; pfam03600 426117015093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117015094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117015095 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 426117015096 putative dimerization interface [polypeptide binding]; other site 426117015097 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 426117015098 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426117015099 heme-binding site [chemical binding]; other site 426117015100 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426117015101 FAD binding pocket [chemical binding]; other site 426117015102 FAD binding motif [chemical binding]; other site 426117015103 phosphate binding motif [ion binding]; other site 426117015104 beta-alpha-beta structure motif; other site 426117015105 NAD binding pocket [chemical binding]; other site 426117015106 Heme binding pocket [chemical binding]; other site 426117015107 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426117015108 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117015109 active site 426117015110 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426117015111 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 426117015112 active site 426117015113 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 426117015114 Strictosidine synthase; Region: Str_synth; pfam03088 426117015115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015116 putative substrate translocation pore; other site 426117015117 hypothetical protein; Validated; Region: PRK06201 426117015118 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 426117015119 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117015120 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426117015121 NAD binding site [chemical binding]; other site 426117015122 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 426117015123 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426117015124 FAD binding domain; Region: FAD_binding_4; pfam01565 426117015125 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426117015126 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117015127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015128 putative substrate translocation pore; other site 426117015129 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426117015130 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426117015131 Bacterial transcriptional regulator; Region: IclR; pfam01614 426117015132 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 426117015133 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117015134 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426117015135 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 426117015136 putative NAD(P) binding site [chemical binding]; other site 426117015137 Cupin domain; Region: Cupin_2; pfam07883 426117015138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117015139 Zn2+ binding site [ion binding]; other site 426117015140 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 426117015141 Mg2+ binding site [ion binding]; other site 426117015142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117015143 DNA-binding site [nucleotide binding]; DNA binding site 426117015144 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426117015145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117015146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117015147 homodimer interface [polypeptide binding]; other site 426117015148 catalytic residue [active] 426117015149 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 426117015150 classical (c) SDRs; Region: SDR_c; cd05233 426117015151 NAD(P) binding site [chemical binding]; other site 426117015152 active site 426117015153 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 426117015154 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117015155 active site 426117015156 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117015157 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117015158 Walker A/P-loop; other site 426117015159 ATP binding site [chemical binding]; other site 426117015160 Q-loop/lid; other site 426117015161 ABC transporter signature motif; other site 426117015162 Walker B; other site 426117015163 D-loop; other site 426117015164 H-loop/switch region; other site 426117015165 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117015166 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117015167 Walker A/P-loop; other site 426117015168 ATP binding site [chemical binding]; other site 426117015169 Q-loop/lid; other site 426117015170 ABC transporter signature motif; other site 426117015171 Walker B; other site 426117015172 D-loop; other site 426117015173 H-loop/switch region; other site 426117015174 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426117015175 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117015176 TM-ABC transporter signature motif; other site 426117015177 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117015178 TM-ABC transporter signature motif; other site 426117015179 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117015180 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 426117015181 putative ligand binding site [chemical binding]; other site 426117015182 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426117015183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117015184 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426117015185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117015186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117015187 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 426117015188 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 426117015189 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 426117015190 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 426117015191 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 426117015192 PRC-barrel domain; Region: PRC; pfam05239 426117015193 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426117015194 hypothetical protein; Provisional; Region: PRK06184 426117015195 ATP10 protein; Region: ATP-synt_10; pfam05176 426117015196 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 426117015197 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 426117015198 malonyl-CoA binding site [chemical binding]; other site 426117015199 dimer interface [polypeptide binding]; other site 426117015200 active site 426117015201 product binding site; other site 426117015202 Phospholipid methyltransferase; Region: PEMT; cl17370 426117015203 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426117015204 hypothetical protein; Validated; Region: PRK00068 426117015205 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 426117015206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117015207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117015208 ligand binding site [chemical binding]; other site 426117015209 flexible hinge region; other site 426117015210 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 426117015211 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426117015212 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 426117015213 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117015214 NAD(P) binding site [chemical binding]; other site 426117015215 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426117015216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117015217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117015218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117015219 dimerization interface [polypeptide binding]; other site 426117015220 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 426117015221 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 426117015222 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 426117015223 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426117015224 DNA polymerase II large subunit; Validated; Region: PRK04023 426117015225 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426117015226 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426117015227 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426117015228 NnrS protein; Region: NnrS; pfam05940 426117015229 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 426117015230 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 426117015231 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 426117015232 MPT binding site; other site 426117015233 trimer interface [polypeptide binding]; other site 426117015234 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 426117015235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117015236 FeS/SAM binding site; other site 426117015237 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 426117015238 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 426117015239 active site clefts [active] 426117015240 zinc binding site [ion binding]; other site 426117015241 dimer interface [polypeptide binding]; other site 426117015242 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 426117015243 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 426117015244 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 426117015245 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 426117015246 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 426117015247 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 426117015248 4Fe-4S binding domain; Region: Fer4; cl02805 426117015249 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 426117015250 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 426117015251 [4Fe-4S] binding site [ion binding]; other site 426117015252 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015253 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015254 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015255 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 426117015256 molybdopterin cofactor binding site; other site 426117015257 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426117015258 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426117015259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015260 putative substrate translocation pore; other site 426117015261 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 426117015262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117015263 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 426117015264 iron-sulfur cluster [ion binding]; other site 426117015265 [2Fe-2S] cluster binding site [ion binding]; other site 426117015266 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117015267 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117015268 Walker A/P-loop; other site 426117015269 ATP binding site [chemical binding]; other site 426117015270 Q-loop/lid; other site 426117015271 ABC transporter signature motif; other site 426117015272 Walker B; other site 426117015273 D-loop; other site 426117015274 H-loop/switch region; other site 426117015275 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117015276 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117015277 Walker A/P-loop; other site 426117015278 ATP binding site [chemical binding]; other site 426117015279 Q-loop/lid; other site 426117015280 ABC transporter signature motif; other site 426117015281 Walker B; other site 426117015282 D-loop; other site 426117015283 H-loop/switch region; other site 426117015284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117015285 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117015286 TM-ABC transporter signature motif; other site 426117015287 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117015288 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117015289 TM-ABC transporter signature motif; other site 426117015290 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117015291 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426117015292 ligand binding site [chemical binding]; other site 426117015293 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 426117015294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117015295 catalytic loop [active] 426117015296 iron binding site [ion binding]; other site 426117015297 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117015298 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 426117015299 putative hydrophobic ligand binding site [chemical binding]; other site 426117015300 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426117015301 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117015302 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117015303 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117015304 dihydroorotase; Provisional; Region: PRK09237 426117015305 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117015306 active site 426117015307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117015308 MarR family; Region: MarR; pfam01047 426117015309 benzoate transport; Region: 2A0115; TIGR00895 426117015310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015311 putative substrate translocation pore; other site 426117015312 aconitate hydratase; Validated; Region: PRK07229 426117015313 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 426117015314 substrate binding site [chemical binding]; other site 426117015315 ligand binding site [chemical binding]; other site 426117015316 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 426117015317 substrate binding site [chemical binding]; other site 426117015318 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 426117015319 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 426117015320 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426117015321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117015322 active site 426117015323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015324 putative active site [active] 426117015325 heme pocket [chemical binding]; other site 426117015326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426117015327 Histidine kinase; Region: HisKA_3; pfam07730 426117015328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015329 ATP binding site [chemical binding]; other site 426117015330 Mg2+ binding site [ion binding]; other site 426117015331 G-X-G motif; other site 426117015332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117015333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117015334 active site 426117015335 phosphorylation site [posttranslational modification] 426117015336 intermolecular recognition site; other site 426117015337 dimerization interface [polypeptide binding]; other site 426117015338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117015339 DNA binding residues [nucleotide binding] 426117015340 dimerization interface [polypeptide binding]; other site 426117015341 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 426117015342 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117015343 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117015344 putative switch regulator; other site 426117015345 non-specific DNA interactions [nucleotide binding]; other site 426117015346 DNA binding site [nucleotide binding] 426117015347 sequence specific DNA binding site [nucleotide binding]; other site 426117015348 putative cAMP binding site [chemical binding]; other site 426117015349 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426117015350 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426117015351 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426117015352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117015353 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117015354 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 426117015355 Domain of unknown function DUF21; Region: DUF21; pfam01595 426117015356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426117015357 Transporter associated domain; Region: CorC_HlyC; smart01091 426117015358 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 426117015359 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 426117015360 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 426117015361 dinuclear metal binding motif [ion binding]; other site 426117015362 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 426117015363 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 426117015364 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 426117015365 Subunit I/III interface [polypeptide binding]; other site 426117015366 Subunit III/IV interface [polypeptide binding]; other site 426117015367 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426117015368 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 426117015369 D-pathway; other site 426117015370 Putative ubiquinol binding site [chemical binding]; other site 426117015371 Low-spin heme (heme b) binding site [chemical binding]; other site 426117015372 Putative water exit pathway; other site 426117015373 Binuclear center (heme o3/CuB) [ion binding]; other site 426117015374 K-pathway; other site 426117015375 Putative proton exit pathway; other site 426117015376 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 426117015377 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117015378 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 426117015379 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117015380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015381 putative substrate translocation pore; other site 426117015382 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426117015383 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 426117015384 CoenzymeA binding site [chemical binding]; other site 426117015385 subunit interaction site [polypeptide binding]; other site 426117015386 PHB binding site; other site 426117015387 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 426117015388 Phasin protein; Region: Phasin_2; cl11491 426117015389 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426117015390 HerA helicase [Replication, recombination, and repair]; Region: COG0433 426117015391 Domain of unknown function DUF87; Region: DUF87; pfam01935 426117015392 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 426117015393 aromatic arch; other site 426117015394 DCoH dimer interaction site [polypeptide binding]; other site 426117015395 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 426117015396 DCoH tetramer interaction site [polypeptide binding]; other site 426117015397 substrate binding site [chemical binding]; other site 426117015398 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426117015399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117015400 membrane-bound complex binding site; other site 426117015401 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426117015402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117015403 dimer interface [polypeptide binding]; other site 426117015404 conserved gate region; other site 426117015405 putative PBP binding loops; other site 426117015406 ABC-ATPase subunit interface; other site 426117015407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117015408 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 426117015409 Walker A/P-loop; other site 426117015410 ATP binding site [chemical binding]; other site 426117015411 Q-loop/lid; other site 426117015412 ABC transporter signature motif; other site 426117015413 Walker B; other site 426117015414 D-loop; other site 426117015415 H-loop/switch region; other site 426117015416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426117015417 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426117015418 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426117015419 Trp docking motif [polypeptide binding]; other site 426117015420 dimer interface [polypeptide binding]; other site 426117015421 active site 426117015422 small subunit binding site [polypeptide binding]; other site 426117015423 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 426117015424 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 426117015425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117015426 substrate binding pocket [chemical binding]; other site 426117015427 membrane-bound complex binding site; other site 426117015428 hinge residues; other site 426117015429 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426117015430 active site residue [active] 426117015431 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 426117015432 catalytic center binding site [active] 426117015433 ATP binding site [chemical binding]; other site 426117015434 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 426117015435 homooctamer interface [polypeptide binding]; other site 426117015436 active site 426117015437 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 426117015438 dihydropteroate synthase; Region: DHPS; TIGR01496 426117015439 substrate binding pocket [chemical binding]; other site 426117015440 dimer interface [polypeptide binding]; other site 426117015441 inhibitor binding site; inhibition site 426117015442 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 426117015443 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 426117015444 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 426117015445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426117015446 dimerization interface [polypeptide binding]; other site 426117015447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117015448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117015449 dimer interface [polypeptide binding]; other site 426117015450 phosphorylation site [posttranslational modification] 426117015451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015452 ATP binding site [chemical binding]; other site 426117015453 Mg2+ binding site [ion binding]; other site 426117015454 G-X-G motif; other site 426117015455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117015456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117015457 active site 426117015458 phosphorylation site [posttranslational modification] 426117015459 intermolecular recognition site; other site 426117015460 dimerization interface [polypeptide binding]; other site 426117015461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117015462 DNA binding site [nucleotide binding] 426117015463 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 426117015464 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 426117015465 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 426117015466 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 426117015467 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 426117015468 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 426117015469 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 426117015470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117015471 FeS/SAM binding site; other site 426117015472 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 426117015473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117015474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117015475 NAD(P) binding site [chemical binding]; other site 426117015476 active site 426117015477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117015478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117015479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117015480 dimerization interface [polypeptide binding]; other site 426117015481 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 426117015482 domain_subunit interface; other site 426117015483 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 426117015484 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 426117015485 FTR, proximal lobe; Region: FTR_C; pfam02741 426117015486 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 426117015487 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426117015488 active site 426117015489 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015490 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 426117015491 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 426117015492 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 426117015493 NAD(P) binding pocket [chemical binding]; other site 426117015494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117015495 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 426117015496 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 426117015497 trimer interface I [polypeptide binding]; other site 426117015498 putative substrate binding pocket [chemical binding]; other site 426117015499 trimer interface II [polypeptide binding]; other site 426117015500 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426117015501 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 426117015502 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 426117015503 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 426117015504 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 426117015505 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 426117015506 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 426117015507 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426117015508 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 426117015509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117015510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117015511 metal binding site [ion binding]; metal-binding site 426117015512 active site 426117015513 I-site; other site 426117015514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117015515 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 426117015516 putative active site pocket [active] 426117015517 dimerization interface [polypeptide binding]; other site 426117015518 putative catalytic residue [active] 426117015519 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 426117015520 Zn binding site [ion binding]; other site 426117015521 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 426117015522 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 426117015523 [2Fe-2S] cluster binding site [ion binding]; other site 426117015524 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 426117015525 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426117015526 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426117015527 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 426117015528 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 426117015529 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426117015530 aminotransferase; Validated; Region: PRK09148 426117015531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117015532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117015533 homodimer interface [polypeptide binding]; other site 426117015534 catalytic residue [active] 426117015535 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 426117015536 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426117015537 MarR family; Region: MarR_2; pfam12802 426117015538 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426117015539 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 426117015540 Cl- selectivity filter; other site 426117015541 Cl- binding residues [ion binding]; other site 426117015542 pore gating glutamate residue; other site 426117015543 dimer interface [polypeptide binding]; other site 426117015544 FOG: CBS domain [General function prediction only]; Region: COG0517 426117015545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 426117015546 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 426117015547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117015548 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 426117015549 Subunit I/III interface [polypeptide binding]; other site 426117015550 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426117015551 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 426117015552 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 426117015553 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426117015554 Cytochrome c; Region: Cytochrom_C; pfam00034 426117015555 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426117015556 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 426117015557 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 426117015558 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 426117015559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015560 molybdopterin cofactor binding site; other site 426117015561 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 426117015562 4Fe-4S binding domain; Region: Fer4_2; pfam12797 426117015563 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426117015564 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 426117015565 heme-binding residues [chemical binding]; other site 426117015566 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 426117015567 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426117015568 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 426117015569 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015570 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015571 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426117015573 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 426117015574 molybdopterin cofactor binding site; other site 426117015575 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 426117015576 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 426117015577 diiron binding motif [ion binding]; other site 426117015578 Uncharacterized conserved protein [Function unknown]; Region: COG1633 426117015579 CCC1-related protein family; Region: CCC1_like_1; cd02437 426117015580 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 426117015581 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 426117015582 motif 1; other site 426117015583 active site 426117015584 motif 2; other site 426117015585 motif 3; other site 426117015586 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426117015587 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 426117015588 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 426117015589 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 426117015590 NAD binding site [chemical binding]; other site 426117015591 substrate binding site [chemical binding]; other site 426117015592 homodimer interface [polypeptide binding]; other site 426117015593 active site 426117015594 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 426117015595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117015596 NAD(P) binding site [chemical binding]; other site 426117015597 active site 426117015598 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 426117015599 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 426117015600 substrate binding site; other site 426117015601 tetramer interface; other site 426117015602 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 426117015603 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 426117015604 active site 426117015605 HIGH motif; other site 426117015606 dimer interface [polypeptide binding]; other site 426117015607 KMSKS motif; other site 426117015608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 426117015609 RNA binding surface [nucleotide binding]; other site 426117015610 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 426117015611 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 426117015612 AMIN domain; Region: AMIN; pfam11741 426117015613 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 426117015614 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 426117015615 active site 426117015616 metal binding site [ion binding]; metal-binding site 426117015617 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 426117015618 Transglycosylase; Region: Transgly; pfam00912 426117015619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426117015620 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 426117015621 peptide chain release factor 2; Provisional; Region: PRK07342 426117015622 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426117015623 RF-1 domain; Region: RF-1; pfam00472 426117015624 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426117015625 Peptidase family M23; Region: Peptidase_M23; pfam01551 426117015626 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 426117015627 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117015628 catalytic triad [active] 426117015629 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426117015630 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 426117015631 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426117015632 substrate binding site [chemical binding]; other site 426117015633 ATP binding site [chemical binding]; other site 426117015634 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426117015635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117015636 DNA-binding site [nucleotide binding]; DNA binding site 426117015637 UTRA domain; Region: UTRA; pfam07702 426117015638 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426117015639 NAD-dependent deacetylase; Provisional; Region: PRK00481 426117015640 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 426117015641 NAD+ binding site [chemical binding]; other site 426117015642 substrate binding site [chemical binding]; other site 426117015643 Zn binding site [ion binding]; other site 426117015644 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426117015645 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 426117015646 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 426117015647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015648 putative substrate translocation pore; other site 426117015649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117015650 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 426117015651 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 426117015652 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 426117015653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117015654 dimer interface [polypeptide binding]; other site 426117015655 conserved gate region; other site 426117015656 putative PBP binding loops; other site 426117015657 ABC-ATPase subunit interface; other site 426117015658 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426117015659 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426117015660 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117015661 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 426117015662 Walker A/P-loop; other site 426117015663 ATP binding site [chemical binding]; other site 426117015664 Q-loop/lid; other site 426117015665 ABC transporter signature motif; other site 426117015666 Walker B; other site 426117015667 D-loop; other site 426117015668 H-loop/switch region; other site 426117015669 TOBE domain; Region: TOBE_2; pfam08402 426117015670 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 426117015671 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 426117015672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117015673 active site 426117015674 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 426117015675 Domain of unknown function DUF302; Region: DUF302; cl01364 426117015676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426117015677 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 426117015678 cystathionine beta-lyase; Provisional; Region: PRK05967 426117015679 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117015680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117015681 catalytic residue [active] 426117015682 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 426117015683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117015684 substrate binding pocket [chemical binding]; other site 426117015685 membrane-bound complex binding site; other site 426117015686 hinge residues; other site 426117015687 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 426117015688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117015689 conserved gate region; other site 426117015690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117015691 putative PBP binding loops; other site 426117015692 dimer interface [polypeptide binding]; other site 426117015693 ABC-ATPase subunit interface; other site 426117015694 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426117015695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117015696 dimer interface [polypeptide binding]; other site 426117015697 conserved gate region; other site 426117015698 putative PBP binding loops; other site 426117015699 ABC-ATPase subunit interface; other site 426117015700 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426117015701 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426117015702 Walker A/P-loop; other site 426117015703 ATP binding site [chemical binding]; other site 426117015704 Q-loop/lid; other site 426117015705 ABC transporter signature motif; other site 426117015706 Walker B; other site 426117015707 D-loop; other site 426117015708 H-loop/switch region; other site 426117015709 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 426117015710 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 426117015711 active site residue [active] 426117015712 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 426117015713 active site residue [active] 426117015714 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 426117015715 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 426117015716 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 426117015717 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 426117015718 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 426117015719 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 426117015720 HIGH motif; other site 426117015721 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426117015722 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 426117015723 active site 426117015724 KMSKS motif; other site 426117015725 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 426117015726 tRNA binding surface [nucleotide binding]; other site 426117015727 anticodon binding site; other site 426117015728 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 426117015729 Cytochrome P450; Region: p450; cl12078 426117015730 cyclase homology domain; Region: CHD; cd07302 426117015731 nucleotidyl binding site; other site 426117015732 metal binding site [ion binding]; metal-binding site 426117015733 dimer interface [polypeptide binding]; other site 426117015734 AAA ATPase domain; Region: AAA_16; pfam13191 426117015735 Uncharacterized conserved protein [Function unknown]; Region: COG1742 426117015736 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426117015737 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117015738 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117015739 protein binding site [polypeptide binding]; other site 426117015740 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426117015741 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117015742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117015743 putative substrate translocation pore; other site 426117015744 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 426117015745 enolase; Provisional; Region: eno; PRK00077 426117015746 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 426117015747 dimer interface [polypeptide binding]; other site 426117015748 metal binding site [ion binding]; metal-binding site 426117015749 substrate binding pocket [chemical binding]; other site 426117015750 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 426117015751 Septum formation initiator; Region: DivIC; pfam04977 426117015752 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 426117015753 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 426117015754 tetramer interface [polypeptide binding]; other site 426117015755 TPP-binding site [chemical binding]; other site 426117015756 heterodimer interface [polypeptide binding]; other site 426117015757 phosphorylation loop region [posttranslational modification] 426117015758 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 426117015759 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117015760 E3 interaction surface; other site 426117015761 lipoyl attachment site [posttranslational modification]; other site 426117015762 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 426117015763 alpha subunit interface [polypeptide binding]; other site 426117015764 TPP binding site [chemical binding]; other site 426117015765 heterodimer interface [polypeptide binding]; other site 426117015766 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426117015767 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426117015768 putative active site [active] 426117015769 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426117015770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117015771 E3 interaction surface; other site 426117015772 lipoyl attachment site [posttranslational modification]; other site 426117015773 e3 binding domain; Region: E3_binding; pfam02817 426117015774 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426117015775 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 426117015776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117015777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117015778 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426117015779 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117015780 TadE-like protein; Region: TadE; pfam07811 426117015781 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117015782 cyclase homology domain; Region: CHD; cd07302 426117015783 nucleotidyl binding site; other site 426117015784 metal binding site [ion binding]; metal-binding site 426117015785 dimer interface [polypeptide binding]; other site 426117015786 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117015787 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426117015788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015789 putative active site [active] 426117015790 PAS fold; Region: PAS_3; pfam08447 426117015791 heme pocket [chemical binding]; other site 426117015792 PAS domain S-box; Region: sensory_box; TIGR00229 426117015793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117015794 GAF domain; Region: GAF; pfam01590 426117015795 PAS domain S-box; Region: sensory_box; TIGR00229 426117015796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015797 putative active site [active] 426117015798 heme pocket [chemical binding]; other site 426117015799 Tetratricopeptide repeat; Region: TPR_16; pfam13432 426117015800 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426117015801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117015802 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117015803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117015804 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 426117015805 circadian clock protein KaiC; Reviewed; Region: PRK09302 426117015806 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 426117015807 Walker A motif; other site 426117015808 ATP binding site [chemical binding]; other site 426117015809 Walker B motif; other site 426117015810 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117015811 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117015812 Walker A motif; other site 426117015813 Walker A motif; other site 426117015814 ATP binding site [chemical binding]; other site 426117015815 Walker B motif; other site 426117015816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117015817 HWE histidine kinase; Region: HWE_HK; pfam07536 426117015818 Predicted membrane protein [Function unknown]; Region: COG2261 426117015819 lipoyl synthase; Provisional; Region: PRK05481 426117015820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117015821 FeS/SAM binding site; other site 426117015822 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 426117015823 putative coenzyme Q binding site [chemical binding]; other site 426117015824 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 426117015825 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 426117015826 substrate binding site; other site 426117015827 dimer interface; other site 426117015828 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 426117015829 homotrimer interaction site [polypeptide binding]; other site 426117015830 zinc binding site [ion binding]; other site 426117015831 CDP-binding sites; other site 426117015832 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 426117015833 FMN binding site [chemical binding]; other site 426117015834 active site 426117015835 catalytic residues [active] 426117015836 substrate binding site [chemical binding]; other site 426117015837 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117015838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117015839 dimer interface [polypeptide binding]; other site 426117015840 phosphorylation site [posttranslational modification] 426117015841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015842 ATP binding site [chemical binding]; other site 426117015843 Mg2+ binding site [ion binding]; other site 426117015844 G-X-G motif; other site 426117015845 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 426117015846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117015847 active site 426117015848 phosphorylation site [posttranslational modification] 426117015849 intermolecular recognition site; other site 426117015850 dimerization interface [polypeptide binding]; other site 426117015851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117015852 Walker A motif; other site 426117015853 ATP binding site [chemical binding]; other site 426117015854 Walker B motif; other site 426117015855 arginine finger; other site 426117015856 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 426117015857 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117015858 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 426117015859 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 426117015860 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 426117015861 Cu(I) binding site [ion binding]; other site 426117015862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117015863 NADH(P)-binding; Region: NAD_binding_10; pfam13460 426117015864 NAD(P) binding site [chemical binding]; other site 426117015865 active site 426117015866 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 426117015867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117015868 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 426117015869 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 426117015870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117015871 dimerization interface [polypeptide binding]; other site 426117015872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117015873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117015874 dimer interface [polypeptide binding]; other site 426117015875 phosphorylation site [posttranslational modification] 426117015876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117015877 ATP binding site [chemical binding]; other site 426117015878 Mg2+ binding site [ion binding]; other site 426117015879 G-X-G motif; other site 426117015880 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426117015881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117015882 active site 426117015883 phosphorylation site [posttranslational modification] 426117015884 intermolecular recognition site; other site 426117015885 dimerization interface [polypeptide binding]; other site 426117015886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117015887 Walker A motif; other site 426117015888 ATP binding site [chemical binding]; other site 426117015889 Walker B motif; other site 426117015890 arginine finger; other site 426117015891 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117015892 bacterial Hfq-like; Region: Hfq; cd01716 426117015893 hexamer interface [polypeptide binding]; other site 426117015894 Sm1 motif; other site 426117015895 RNA binding site [nucleotide binding]; other site 426117015896 Sm2 motif; other site 426117015897 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 426117015898 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 426117015899 HflX GTPase family; Region: HflX; cd01878 426117015900 G1 box; other site 426117015901 GTP/Mg2+ binding site [chemical binding]; other site 426117015902 Switch I region; other site 426117015903 G2 box; other site 426117015904 G3 box; other site 426117015905 Switch II region; other site 426117015906 G4 box; other site 426117015907 G5 box; other site 426117015908 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426117015909 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 426117015910 putative heme binding pocket [chemical binding]; other site 426117015911 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 426117015912 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 426117015913 homodimer interface [polypeptide binding]; other site 426117015914 metal binding site [ion binding]; metal-binding site 426117015915 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 426117015916 homodimer interface [polypeptide binding]; other site 426117015917 active site 426117015918 putative chemical substrate binding site [chemical binding]; other site 426117015919 metal binding site [ion binding]; metal-binding site 426117015920 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 426117015921 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 426117015922 Catalytic site [active] 426117015923 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 426117015924 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 426117015925 heterodimer interface [polypeptide binding]; other site 426117015926 homodimer interface [polypeptide binding]; other site 426117015927 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 426117015928 nucleophilic elbow; other site 426117015929 catalytic triad; other site 426117015930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 426117015931 Terminase-like family; Region: Terminase_6; pfam03237 426117015932 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 426117015933 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 426117015934 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 426117015935 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 426117015936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 426117015937 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 426117015938 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 426117015939 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 426117015940 Phage major tail protein 2; Region: Phage_tail_2; cl11463 426117015941 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 426117015942 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 426117015943 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 426117015944 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 426117015945 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 426117015946 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 426117015947 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 426117015948 NlpC/P60 family; Region: NLPC_P60; cl17555 426117015949 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 426117015950 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 426117015951 Putative phage tail protein; Region: Phage-tail_3; pfam13550 426117015952 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 426117015953 catalytic residue [active] 426117015954 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 426117015955 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 426117015956 GTP binding site; other site 426117015957 Domain of unknown function DUF59; Region: DUF59; cl00941 426117015958 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 426117015959 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426117015960 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 426117015961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117015962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117015963 DNA binding residues [nucleotide binding] 426117015964 von Willebrand factor; Region: vWF_A; pfam12450 426117015965 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 426117015966 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 426117015967 metal ion-dependent adhesion site (MIDAS); other site 426117015968 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 426117015969 short chain dehydrogenase; Provisional; Region: PRK08339 426117015970 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 426117015971 putative NAD(P) binding site [chemical binding]; other site 426117015972 putative active site [active] 426117015973 argininosuccinate lyase; Provisional; Region: PRK00855 426117015974 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 426117015975 active sites [active] 426117015976 tetramer interface [polypeptide binding]; other site 426117015977 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 426117015978 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426117015979 catalytic residues [active] 426117015980 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 426117015981 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 426117015982 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 426117015983 putative active site [active] 426117015984 putative PHP Thumb interface [polypeptide binding]; other site 426117015985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117015986 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 426117015987 generic binding surface II; other site 426117015988 generic binding surface I; other site 426117015989 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 426117015990 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 426117015991 CPxP motif; other site 426117015992 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426117015993 dimer interface [polypeptide binding]; other site 426117015994 ADP-ribose binding site [chemical binding]; other site 426117015995 active site 426117015996 nudix motif; other site 426117015997 metal binding site [ion binding]; metal-binding site 426117015998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117015999 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117016000 Cell division protein ZapA; Region: ZapA; pfam05164 426117016001 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 426117016002 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 426117016003 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426117016004 Phosphoglycerate kinase; Region: PGK; pfam00162 426117016005 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 426117016006 substrate binding site [chemical binding]; other site 426117016007 hinge regions; other site 426117016008 ADP binding site [chemical binding]; other site 426117016009 catalytic site [active] 426117016010 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 426117016011 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 426117016012 intersubunit interface [polypeptide binding]; other site 426117016013 active site 426117016014 zinc binding site [ion binding]; other site 426117016015 Na+ binding site [ion binding]; other site 426117016016 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426117016017 thiamine phosphate binding site [chemical binding]; other site 426117016018 active site 426117016019 pyrophosphate binding site [ion binding]; other site 426117016020 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117016021 Sel1-like repeats; Region: SEL1; smart00671 426117016022 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426117016023 Sel1-like repeats; Region: SEL1; smart00671 426117016024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426117016025 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 426117016026 active site 426117016027 dimerization interface [polypeptide binding]; other site 426117016028 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 426117016029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117016030 active site 426117016031 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 426117016032 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 426117016033 tetramer interface [polypeptide binding]; other site 426117016034 active site 426117016035 Mg2+/Mn2+ binding site [ion binding]; other site 426117016036 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426117016037 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117016038 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426117016039 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 426117016040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117016041 NAD(P) binding site [chemical binding]; other site 426117016042 active site 426117016043 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117016044 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 426117016045 putative NAD(P) binding site [chemical binding]; other site 426117016046 active site 426117016047 putative substrate binding site [chemical binding]; other site 426117016048 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 426117016049 HAMP domain; Region: HAMP; pfam00672 426117016050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117016051 dimer interface [polypeptide binding]; other site 426117016052 phosphorylation site [posttranslational modification] 426117016053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117016054 ATP binding site [chemical binding]; other site 426117016055 Mg2+ binding site [ion binding]; other site 426117016056 G-X-G motif; other site 426117016057 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 426117016058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016059 active site 426117016060 phosphorylation site [posttranslational modification] 426117016061 intermolecular recognition site; other site 426117016062 dimerization interface [polypeptide binding]; other site 426117016063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117016064 DNA binding site [nucleotide binding] 426117016065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117016066 MarR family; Region: MarR_2; pfam12802 426117016067 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 426117016068 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426117016069 homodimer interface [polypeptide binding]; other site 426117016070 substrate-cofactor binding pocket; other site 426117016071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117016072 catalytic residue [active] 426117016073 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 426117016074 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 426117016075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117016076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117016077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117016078 dimerization interface [polypeptide binding]; other site 426117016079 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117016080 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117016081 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 426117016082 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426117016083 TrkA-N domain; Region: TrkA_N; pfam02254 426117016084 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 426117016085 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 426117016086 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 426117016087 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 426117016088 putative active site [active] 426117016089 putative substrate binding site [chemical binding]; other site 426117016090 ATP binding site [chemical binding]; other site 426117016091 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117016092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117016093 DNA-binding site [nucleotide binding]; DNA binding site 426117016094 FCD domain; Region: FCD; pfam07729 426117016095 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426117016096 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 426117016097 DctM-like transporters; Region: DctM; pfam06808 426117016098 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 426117016099 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 426117016100 malonyl-CoA synthase; Validated; Region: PRK07514 426117016101 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 426117016102 acyl-activating enzyme (AAE) consensus motif; other site 426117016103 active site 426117016104 AMP binding site [chemical binding]; other site 426117016105 CoA binding site [chemical binding]; other site 426117016106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117016107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117016108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 426117016109 putative dimerization interface [polypeptide binding]; other site 426117016110 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 426117016111 Iron-sulfur protein interface; other site 426117016112 proximal quinone binding site [chemical binding]; other site 426117016113 SdhD (CybS) interface [polypeptide binding]; other site 426117016114 proximal heme binding site [chemical binding]; other site 426117016115 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 426117016116 putative SdhC subunit interface [polypeptide binding]; other site 426117016117 putative proximal heme binding site [chemical binding]; other site 426117016118 putative Iron-sulfur protein interface [polypeptide binding]; other site 426117016119 putative proximal quinone binding site; other site 426117016120 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 426117016121 L-aspartate oxidase; Provisional; Region: PRK06175 426117016122 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426117016123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117016124 S-adenosylmethionine binding site [chemical binding]; other site 426117016125 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 426117016126 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426117016127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 426117016128 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 426117016129 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426117016130 catalytic residue [active] 426117016131 hypothetical protein; Provisional; Region: PRK05409 426117016132 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 426117016133 Predicted permeases [General function prediction only]; Region: COG0679 426117016134 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 426117016135 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 426117016136 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 426117016137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117016138 S-adenosylmethionine binding site [chemical binding]; other site 426117016139 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426117016140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117016141 RNA binding surface [nucleotide binding]; other site 426117016142 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 426117016143 active site 426117016144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 426117016145 nucleoside/Zn binding site; other site 426117016146 dimer interface [polypeptide binding]; other site 426117016147 catalytic motif [active] 426117016148 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117016149 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426117016150 catalytic site [active] 426117016151 manganese transport protein MntH; Reviewed; Region: PRK00701 426117016152 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426117016153 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426117016154 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426117016155 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 426117016156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426117016157 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 426117016158 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 426117016159 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 426117016160 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 426117016161 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 426117016162 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 426117016163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 426117016164 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 426117016165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 426117016166 catalytic loop [active] 426117016167 iron binding site [ion binding]; other site 426117016168 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 426117016169 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 426117016170 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 426117016171 generic binding surface II; other site 426117016172 generic binding surface I; other site 426117016173 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426117016174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426117016175 catalytic loop [active] 426117016176 iron binding site [ion binding]; other site 426117016177 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426117016178 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426117016179 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117016180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426117016181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117016182 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426117016183 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 426117016184 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 426117016185 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 426117016186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117016187 active site 426117016188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 426117016189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 426117016190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 426117016191 RNA binding site [nucleotide binding]; other site 426117016192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 426117016193 RNA binding site [nucleotide binding]; other site 426117016194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 426117016195 RNA binding site [nucleotide binding]; other site 426117016196 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 426117016197 RNA binding site [nucleotide binding]; other site 426117016198 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 426117016199 RNA binding site [nucleotide binding]; other site 426117016200 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 426117016201 RNA binding site [nucleotide binding]; other site 426117016202 Phosphopantetheine attachment site; Region: PP-binding; cl09936 426117016203 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 426117016204 acyl-CoA synthetase; Validated; Region: PRK05850 426117016205 acyl-activating enzyme (AAE) consensus motif; other site 426117016206 active site 426117016207 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426117016208 B12 binding site [chemical binding]; other site 426117016209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117016210 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117016211 FeS/SAM binding site; other site 426117016212 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 426117016213 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 426117016214 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 426117016215 putative active site [active] 426117016216 putative metal binding residues [ion binding]; other site 426117016217 signature motif; other site 426117016218 putative dimer interface [polypeptide binding]; other site 426117016219 putative phosphate binding site [ion binding]; other site 426117016220 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117016221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117016222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117016223 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117016224 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 426117016225 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 426117016226 putative active site [active] 426117016227 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426117016228 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426117016229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117016230 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426117016231 AAA domain; Region: AAA_31; pfam13614 426117016232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117016233 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 426117016234 putative ADP-binding pocket [chemical binding]; other site 426117016235 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 426117016236 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 426117016237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117016238 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 426117016239 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426117016240 Predicted kinase [General function prediction only]; Region: COG0645 426117016241 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 426117016242 propionate/acetate kinase; Provisional; Region: PRK12379 426117016243 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 426117016244 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 426117016245 dimer interaction site [polypeptide binding]; other site 426117016246 substrate-binding tunnel; other site 426117016247 active site 426117016248 catalytic site [active] 426117016249 substrate binding site [chemical binding]; other site 426117016250 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 426117016251 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 426117016252 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426117016253 NAD binding site [chemical binding]; other site 426117016254 homotetramer interface [polypeptide binding]; other site 426117016255 homodimer interface [polypeptide binding]; other site 426117016256 substrate binding site [chemical binding]; other site 426117016257 active site 426117016258 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 426117016259 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 426117016260 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426117016261 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426117016262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117016263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117016264 Ligand Binding Site [chemical binding]; other site 426117016265 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426117016266 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 426117016267 putative dimer interface [polypeptide binding]; other site 426117016268 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 426117016269 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 426117016270 putative NAD(P) binding site [chemical binding]; other site 426117016271 putative substrate binding site [chemical binding]; other site 426117016272 catalytic Zn binding site [ion binding]; other site 426117016273 structural Zn binding site [ion binding]; other site 426117016274 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117016275 ligand binding site [chemical binding]; other site 426117016276 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117016277 putative switch regulator; other site 426117016278 non-specific DNA interactions [nucleotide binding]; other site 426117016279 DNA binding site [nucleotide binding] 426117016280 sequence specific DNA binding site [nucleotide binding]; other site 426117016281 putative cAMP binding site [chemical binding]; other site 426117016282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016283 active site 426117016284 phosphorylation site [posttranslational modification] 426117016285 intermolecular recognition site; other site 426117016286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016287 active site 426117016288 phosphorylation site [posttranslational modification] 426117016289 intermolecular recognition site; other site 426117016290 dimerization interface [polypeptide binding]; other site 426117016291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117016292 DNA binding residues [nucleotide binding] 426117016293 dimerization interface [polypeptide binding]; other site 426117016294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426117016295 PAS fold; Region: PAS_3; pfam08447 426117016296 putative active site [active] 426117016297 heme pocket [chemical binding]; other site 426117016298 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426117016299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117016300 putative active site [active] 426117016301 heme pocket [chemical binding]; other site 426117016302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117016303 dimer interface [polypeptide binding]; other site 426117016304 phosphorylation site [posttranslational modification] 426117016305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117016306 ATP binding site [chemical binding]; other site 426117016307 Mg2+ binding site [ion binding]; other site 426117016308 G-X-G motif; other site 426117016309 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 426117016310 putative active site [active] 426117016311 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 426117016312 RHS Repeat; Region: RHS_repeat; pfam05593 426117016313 RHS Repeat; Region: RHS_repeat; pfam05593 426117016314 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 426117016315 RHS Repeat; Region: RHS_repeat; cl11982 426117016316 RHS Repeat; Region: RHS_repeat; pfam05593 426117016317 RHS Repeat; Region: RHS_repeat; pfam05593 426117016318 RHS Repeat; Region: RHS_repeat; pfam05593 426117016319 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 426117016320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117016321 FeS/SAM binding site; other site 426117016322 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426117016323 selenophosphate synthetase; Provisional; Region: PRK00943 426117016324 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 426117016325 dimerization interface [polypeptide binding]; other site 426117016326 putative ATP binding site [chemical binding]; other site 426117016327 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 426117016328 heme-binding site [chemical binding]; other site 426117016329 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117016330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117016331 dimer interface [polypeptide binding]; other site 426117016332 putative CheW interface [polypeptide binding]; other site 426117016333 non-specific DNA binding site [nucleotide binding]; other site 426117016334 salt bridge; other site 426117016335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426117016336 sequence-specific DNA binding site [nucleotide binding]; other site 426117016337 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 426117016338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 426117016339 Helix-turn-helix domain; Region: HTH_18; pfam12833 426117016340 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426117016341 EamA-like transporter family; Region: EamA; pfam00892 426117016342 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426117016343 Ligand Binding Site [chemical binding]; other site 426117016344 Biofilm formation and stress response factor; Region: BsmA; pfam10014 426117016345 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 426117016346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117016347 ligand binding site [chemical binding]; other site 426117016348 flexible hinge region; other site 426117016349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117016350 putative switch regulator; other site 426117016351 non-specific DNA interactions [nucleotide binding]; other site 426117016352 DNA binding site [nucleotide binding] 426117016353 sequence specific DNA binding site [nucleotide binding]; other site 426117016354 putative cAMP binding site [chemical binding]; other site 426117016355 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426117016356 Ligand Binding Site [chemical binding]; other site 426117016357 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117016358 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 426117016359 ligand binding site [chemical binding]; other site 426117016360 flexible hinge region; other site 426117016361 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117016362 putative switch regulator; other site 426117016363 non-specific DNA interactions [nucleotide binding]; other site 426117016364 DNA binding site [nucleotide binding] 426117016365 sequence specific DNA binding site [nucleotide binding]; other site 426117016366 putative cAMP binding site [chemical binding]; other site 426117016367 Protein of unknown function (DUF465); Region: DUF465; pfam04325 426117016368 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426117016369 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426117016370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117016371 citrate-proton symporter; Provisional; Region: PRK15075 426117016372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117016373 putative substrate translocation pore; other site 426117016374 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426117016375 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 426117016376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016377 active site 426117016378 phosphorylation site [posttranslational modification] 426117016379 intermolecular recognition site; other site 426117016380 dimerization interface [polypeptide binding]; other site 426117016381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117016382 DNA binding site [nucleotide binding] 426117016383 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 426117016384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426117016385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117016386 dimer interface [polypeptide binding]; other site 426117016387 phosphorylation site [posttranslational modification] 426117016388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117016389 ATP binding site [chemical binding]; other site 426117016390 Mg2+ binding site [ion binding]; other site 426117016391 G-X-G motif; other site 426117016392 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426117016393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117016394 putative substrate translocation pore; other site 426117016395 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426117016396 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426117016397 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 426117016398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117016399 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 426117016400 putative dimerization interface [polypeptide binding]; other site 426117016401 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 426117016402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117016403 substrate binding pocket [chemical binding]; other site 426117016404 membrane-bound complex binding site; other site 426117016405 hinge residues; other site 426117016406 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426117016407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426117016408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117016409 catalytic residue [active] 426117016410 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426117016411 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426117016412 Bacterial transcriptional regulator; Region: IclR; pfam01614 426117016413 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117016414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117016415 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 426117016416 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426117016417 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 426117016418 Uncharacterized conserved protein [Function unknown]; Region: COG3391 426117016419 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 426117016420 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 426117016421 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 426117016422 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 426117016423 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 426117016424 Chromate transporter; Region: Chromate_transp; pfam02417 426117016425 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 426117016426 active site residue [active] 426117016427 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 426117016428 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117016429 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426117016430 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 426117016431 putative ion selectivity filter; other site 426117016432 putative pore gating glutamate residue; other site 426117016433 putative H+/Cl- coupling transport residue; other site 426117016434 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 426117016435 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426117016436 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 426117016437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117016438 NAD(P) binding site [chemical binding]; other site 426117016439 active site 426117016440 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426117016441 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426117016442 inhibitor site; inhibition site 426117016443 active site 426117016444 dimer interface [polypeptide binding]; other site 426117016445 catalytic residue [active] 426117016446 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426117016447 active site 426117016448 catalytic residues [active] 426117016449 metal binding site [ion binding]; metal-binding site 426117016450 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 426117016451 pyruvate kinase; Provisional; Region: PRK06247 426117016452 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426117016453 domain interfaces; other site 426117016454 active site 426117016455 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 426117016456 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 426117016457 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 426117016458 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 426117016459 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 426117016460 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 426117016461 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 426117016462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 426117016463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117016464 motif II; other site 426117016465 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 426117016466 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 426117016467 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426117016468 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117016469 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426117016470 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426117016471 substrate binding pocket [chemical binding]; other site 426117016472 membrane-bound complex binding site; other site 426117016473 hinge residues; other site 426117016474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117016475 putative CheW interface [polypeptide binding]; other site 426117016476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426117016477 dimerization interface [polypeptide binding]; other site 426117016478 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 426117016479 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 426117016480 NADP binding site [chemical binding]; other site 426117016481 dimer interface [polypeptide binding]; other site 426117016482 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 426117016483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117016484 FeS/SAM binding site; other site 426117016485 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 426117016486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 426117016487 GAF domain; Region: GAF; pfam01590 426117016488 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426117016489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117016490 PAS domain; Region: PAS_9; pfam13426 426117016491 putative active site [active] 426117016492 heme pocket [chemical binding]; other site 426117016493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117016494 metal binding site [ion binding]; metal-binding site 426117016495 active site 426117016496 I-site; other site 426117016497 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117016498 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 426117016499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117016500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 426117016501 putative dimerization interface [polypeptide binding]; other site 426117016502 putative substrate binding pocket [chemical binding]; other site 426117016503 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 426117016504 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 426117016505 active site 426117016506 tetramer interface [polypeptide binding]; other site 426117016507 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 426117016508 tartronate semialdehyde reductase; Provisional; Region: PRK15059 426117016509 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117016510 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117016511 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117016512 ligand binding site [chemical binding]; other site 426117016513 flexible hinge region; other site 426117016514 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117016515 putative switch regulator; other site 426117016516 non-specific DNA interactions [nucleotide binding]; other site 426117016517 DNA binding site [nucleotide binding] 426117016518 sequence specific DNA binding site [nucleotide binding]; other site 426117016519 putative cAMP binding site [chemical binding]; other site 426117016520 CheB methylesterase; Region: CheB_methylest; pfam01339 426117016521 CheB methylesterase; Region: CheB_methylest; pfam01339 426117016522 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426117016523 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426117016524 Protein of unknown function (DUF904); Region: DUF904; pfam06005 426117016525 PAS domain; Region: PAS_10; pfam13596 426117016526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117016527 HWE histidine kinase; Region: HWE_HK; smart00911 426117016528 Response regulator receiver domain; Region: Response_reg; pfam00072 426117016529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016530 active site 426117016531 phosphorylation site [posttranslational modification] 426117016532 intermolecular recognition site; other site 426117016533 dimerization interface [polypeptide binding]; other site 426117016534 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117016535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117016536 Walker A motif; other site 426117016537 ATP binding site [chemical binding]; other site 426117016538 Walker B motif; other site 426117016539 arginine finger; other site 426117016540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426117016541 catalytic core [active] 426117016542 YcjX-like family, DUF463; Region: DUF463; pfam04317 426117016543 Domain of unknown function (DUF697); Region: DUF697; cl12064 426117016544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426117016545 sequence-specific DNA binding site [nucleotide binding]; other site 426117016546 salt bridge; other site 426117016547 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 426117016548 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 426117016549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117016550 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117016551 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 426117016552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426117016553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426117016554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426117016555 active site 426117016556 catalytic tetrad [active] 426117016557 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 426117016558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117016559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117016560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117016561 Walker A/P-loop; other site 426117016562 ATP binding site [chemical binding]; other site 426117016563 Q-loop/lid; other site 426117016564 ABC transporter signature motif; other site 426117016565 Walker B; other site 426117016566 D-loop; other site 426117016567 H-loop/switch region; other site 426117016568 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 426117016569 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 426117016570 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 426117016571 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 426117016572 putative phosphate acyltransferase; Provisional; Region: PRK05331 426117016573 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 426117016574 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 426117016575 dimer interface [polypeptide binding]; other site 426117016576 active site 426117016577 CoA binding pocket [chemical binding]; other site 426117016578 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426117016579 IHF dimer interface [polypeptide binding]; other site 426117016580 IHF - DNA interface [nucleotide binding]; other site 426117016581 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 426117016582 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426117016583 DNA binding residues [nucleotide binding] 426117016584 PrkA family serine protein kinase; Provisional; Region: PRK15455 426117016585 AAA ATPase domain; Region: AAA_16; pfam13191 426117016586 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 426117016587 hypothetical protein; Provisional; Region: PRK05325 426117016588 SpoVR family protein; Provisional; Region: PRK11767 426117016589 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 426117016590 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 426117016591 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 426117016592 L-lactate permease; Region: Lactate_perm; cl00701 426117016593 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 426117016594 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117016595 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117016596 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 426117016597 putative N-terminal domain interface [polypeptide binding]; other site 426117016598 putative dimer interface [polypeptide binding]; other site 426117016599 putative substrate binding pocket (H-site) [chemical binding]; other site 426117016600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117016601 classical (c) SDRs; Region: SDR_c; cd05233 426117016602 NAD(P) binding site [chemical binding]; other site 426117016603 active site 426117016604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117016605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117016606 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 426117016607 putative effector binding pocket; other site 426117016608 putative dimerization interface [polypeptide binding]; other site 426117016609 HerA helicase [Replication, recombination, and repair]; Region: COG0433 426117016610 Domain of unknown function DUF87; Region: DUF87; pfam01935 426117016611 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 426117016612 Flavoprotein; Region: Flavoprotein; pfam02441 426117016613 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 426117016614 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426117016615 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426117016616 putative ligand binding site [chemical binding]; other site 426117016617 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 426117016618 ABC1 family; Region: ABC1; cl17513 426117016619 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 426117016620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117016621 S-adenosylmethionine binding site [chemical binding]; other site 426117016622 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 426117016623 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 426117016624 DNA binding site [nucleotide binding] 426117016625 catalytic residue [active] 426117016626 H2TH interface [polypeptide binding]; other site 426117016627 putative catalytic residues [active] 426117016628 turnover-facilitating residue; other site 426117016629 intercalation triad [nucleotide binding]; other site 426117016630 8OG recognition residue [nucleotide binding]; other site 426117016631 putative reading head residues; other site 426117016632 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 426117016633 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 426117016634 Uncharacterized conserved protein [Function unknown]; Region: COG2928 426117016635 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426117016636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117016637 active site 426117016638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117016639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117016640 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117016641 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 426117016642 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 426117016643 catalytic triad [active] 426117016644 dimer interface [polypeptide binding]; other site 426117016645 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 426117016646 hypothetical protein; Validated; Region: PRK00228 426117016647 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 426117016648 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 426117016649 nucleotide binding site [chemical binding]; other site 426117016650 NEF interaction site [polypeptide binding]; other site 426117016651 SBD interface [polypeptide binding]; other site 426117016652 chaperone protein DnaJ; Provisional; Region: PRK10767 426117016653 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426117016654 HSP70 interaction site [polypeptide binding]; other site 426117016655 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 426117016656 substrate binding site [polypeptide binding]; other site 426117016657 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 426117016658 Zn binding sites [ion binding]; other site 426117016659 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 426117016660 dimer interface [polypeptide binding]; other site 426117016661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117016662 S-adenosylmethionine binding site [chemical binding]; other site 426117016663 Domain of unknown function (DUF336); Region: DUF336; pfam03928 426117016664 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426117016665 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426117016666 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426117016667 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426117016668 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 426117016669 thymidylate kinase; Validated; Region: tmk; PRK00698 426117016670 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 426117016671 TMP-binding site; other site 426117016672 ATP-binding site [chemical binding]; other site 426117016673 DNA polymerase III subunit delta'; Validated; Region: PRK07471 426117016674 DNA polymerase III subunit delta'; Validated; Region: PRK08485 426117016675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117016676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426117016677 NAD(P) binding site [chemical binding]; other site 426117016678 active site 426117016679 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 426117016680 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426117016681 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 426117016682 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 426117016683 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426117016684 active site 426117016685 nucleotide binding site [chemical binding]; other site 426117016686 HIGH motif; other site 426117016687 KMSKS motif; other site 426117016688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117016689 Walker A/P-loop; other site 426117016690 ATP binding site [chemical binding]; other site 426117016691 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117016692 active site 426117016693 metal binding site [ion binding]; metal-binding site 426117016694 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426117016695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117016696 DNA-binding site [nucleotide binding]; DNA binding site 426117016697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117016698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117016699 homodimer interface [polypeptide binding]; other site 426117016700 catalytic residue [active] 426117016701 EamA-like transporter family; Region: EamA; pfam00892 426117016702 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 426117016703 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 426117016704 putative FMN binding site [chemical binding]; other site 426117016705 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 426117016706 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426117016707 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426117016708 catalytic residue [active] 426117016709 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 426117016710 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117016711 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117016712 E3 interaction surface; other site 426117016713 lipoyl attachment site [posttranslational modification]; other site 426117016714 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 426117016715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426117016716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426117016717 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426117016718 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426117016719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426117016720 E3 interaction surface; other site 426117016721 lipoyl attachment site [posttranslational modification]; other site 426117016722 e3 binding domain; Region: E3_binding; pfam02817 426117016723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426117016724 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 426117016725 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 426117016726 dimer interface [polypeptide binding]; other site 426117016727 TPP-binding site [chemical binding]; other site 426117016728 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426117016729 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 426117016730 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 426117016731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117016732 ATP binding site [chemical binding]; other site 426117016733 putative Mg++ binding site [ion binding]; other site 426117016734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117016735 nucleotide binding region [chemical binding]; other site 426117016736 ATP-binding site [chemical binding]; other site 426117016737 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 426117016738 Uncharacterized conserved protein [Function unknown]; Region: COG2938 426117016739 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 426117016740 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 426117016741 generic binding surface II; other site 426117016742 ssDNA binding site; other site 426117016743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117016744 ATP binding site [chemical binding]; other site 426117016745 putative Mg++ binding site [ion binding]; other site 426117016746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117016747 nucleotide binding region [chemical binding]; other site 426117016748 ATP-binding site [chemical binding]; other site 426117016749 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 426117016750 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426117016751 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 426117016752 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426117016753 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 426117016754 transmembrane helices; other site 426117016755 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426117016756 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426117016757 active site 426117016758 nucleophile elbow; other site 426117016759 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 426117016760 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 426117016761 GTP cyclohydrolase I; Provisional; Region: PLN03044 426117016762 active site 426117016763 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 426117016764 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 426117016765 trimerization site [polypeptide binding]; other site 426117016766 active site 426117016767 hypothetical protein; Validated; Region: PRK00041 426117016768 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 426117016769 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 426117016770 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426117016771 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 426117016772 active site 426117016773 dimer interface [polypeptide binding]; other site 426117016774 motif 1; other site 426117016775 motif 2; other site 426117016776 motif 3; other site 426117016777 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 426117016778 anticodon binding site; other site 426117016779 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 426117016780 PhnA protein; Region: PhnA; pfam03831 426117016781 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 426117016782 nudix motif; other site 426117016783 Response regulator receiver domain; Region: Response_reg; pfam00072 426117016784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016785 active site 426117016786 phosphorylation site [posttranslational modification] 426117016787 intermolecular recognition site; other site 426117016788 dimerization interface [polypeptide binding]; other site 426117016789 Dienelactone hydrolase family; Region: DLH; pfam01738 426117016790 putative glutathione S-transferase; Provisional; Region: PRK10357 426117016791 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 426117016792 putative C-terminal domain interface [polypeptide binding]; other site 426117016793 putative GSH binding site (G-site) [chemical binding]; other site 426117016794 putative dimer interface [polypeptide binding]; other site 426117016795 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 426117016796 dimer interface [polypeptide binding]; other site 426117016797 N-terminal domain interface [polypeptide binding]; other site 426117016798 putative substrate binding pocket (H-site) [chemical binding]; other site 426117016799 classical (c) SDRs; Region: SDR_c; cd05233 426117016800 NAD(P) binding site [chemical binding]; other site 426117016801 active site 426117016802 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 426117016803 Amidinotransferase; Region: Amidinotransf; cl12043 426117016804 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 426117016805 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 426117016806 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 426117016807 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 426117016808 ligand binding site; other site 426117016809 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 426117016810 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426117016811 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 426117016812 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 426117016813 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 426117016814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117016815 FeS/SAM binding site; other site 426117016816 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 426117016817 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 426117016818 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 426117016819 Uncharacterized conserved protein [Function unknown]; Region: COG1434 426117016820 putative active site [active] 426117016821 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 426117016822 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426117016823 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 426117016824 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 426117016825 Active site cavity [active] 426117016826 catalytic acid [active] 426117016827 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 426117016828 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426117016829 active site lid residues [active] 426117016830 substrate binding pocket [chemical binding]; other site 426117016831 catalytic residues [active] 426117016832 substrate-Mg2+ binding site; other site 426117016833 aspartate-rich region 1; other site 426117016834 aspartate-rich region 2; other site 426117016835 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426117016836 active site lid residues [active] 426117016837 substrate binding pocket [chemical binding]; other site 426117016838 catalytic residues [active] 426117016839 substrate-Mg2+ binding site; other site 426117016840 aspartate-rich region 1; other site 426117016841 aspartate-rich region 2; other site 426117016842 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 426117016843 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 426117016844 putative NADP binding site [chemical binding]; other site 426117016845 putative substrate binding site [chemical binding]; other site 426117016846 active site 426117016847 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 426117016848 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 426117016849 TPP-binding site; other site 426117016850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426117016851 PYR/PP interface [polypeptide binding]; other site 426117016852 dimer interface [polypeptide binding]; other site 426117016853 TPP binding site [chemical binding]; other site 426117016854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426117016855 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 426117016856 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 426117016857 active site 426117016858 substrate binding site [chemical binding]; other site 426117016859 Mg2+ binding site [ion binding]; other site 426117016860 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 426117016861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117016862 Walker A/P-loop; other site 426117016863 ATP binding site [chemical binding]; other site 426117016864 Q-loop/lid; other site 426117016865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117016866 ABC transporter signature motif; other site 426117016867 Walker B; other site 426117016868 D-loop; other site 426117016869 ABC transporter; Region: ABC_tran_2; pfam12848 426117016870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117016871 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 426117016872 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426117016873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117016874 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 426117016875 active site 426117016876 motif I; other site 426117016877 motif II; other site 426117016878 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 426117016879 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 426117016880 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426117016881 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426117016882 photolyase PhrII; Region: phr2; TIGR00591 426117016883 DNA photolyase; Region: DNA_photolyase; pfam00875 426117016884 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 426117016885 recombination factor protein RarA; Reviewed; Region: PRK13342 426117016886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117016887 ATP binding site [chemical binding]; other site 426117016888 Walker A motif; other site 426117016889 Walker B motif; other site 426117016890 arginine finger; other site 426117016891 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 426117016892 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426117016893 AAA domain; Region: AAA_31; pfam13614 426117016894 P-loop; other site 426117016895 Magnesium ion binding site [ion binding]; other site 426117016896 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426117016897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117016898 RNA binding surface [nucleotide binding]; other site 426117016899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426117016900 active site 426117016901 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426117016902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426117016903 motif II; other site 426117016904 ATP12 chaperone protein; Region: ATP12; cl02228 426117016905 LemA family; Region: LemA; pfam04011 426117016906 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 426117016907 Repair protein; Region: Repair_PSII; pfam04536 426117016908 Repair protein; Region: Repair_PSII; cl01535 426117016909 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 426117016910 nucleophile elbow; other site 426117016911 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426117016912 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426117016913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117016914 Walker A/P-loop; other site 426117016915 ATP binding site [chemical binding]; other site 426117016916 Q-loop/lid; other site 426117016917 ABC transporter signature motif; other site 426117016918 Walker B; other site 426117016919 D-loop; other site 426117016920 H-loop/switch region; other site 426117016921 TOBE domain; Region: TOBE_2; pfam08402 426117016922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117016923 dimer interface [polypeptide binding]; other site 426117016924 conserved gate region; other site 426117016925 putative PBP binding loops; other site 426117016926 ABC-ATPase subunit interface; other site 426117016927 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426117016928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117016929 dimer interface [polypeptide binding]; other site 426117016930 conserved gate region; other site 426117016931 putative PBP binding loops; other site 426117016932 ABC-ATPase subunit interface; other site 426117016933 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426117016934 TadE-like protein; Region: TadE; pfam07811 426117016935 Family of unknown function (DUF490); Region: DUF490; pfam04357 426117016936 Family of unknown function (DUF490); Region: DUF490; pfam04357 426117016937 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 426117016938 Surface antigen; Region: Bac_surface_Ag; pfam01103 426117016939 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426117016940 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 426117016941 putative active site [active] 426117016942 Zn binding site [ion binding]; other site 426117016943 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 426117016944 interface (dimer of trimers) [polypeptide binding]; other site 426117016945 Substrate-binding/catalytic site; other site 426117016946 Zn-binding sites [ion binding]; other site 426117016947 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 426117016948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117016949 TPR motif; other site 426117016950 binding surface 426117016951 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 426117016952 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 426117016953 TPP-binding site; other site 426117016954 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426117016955 PYR/PP interface [polypeptide binding]; other site 426117016956 dimer interface [polypeptide binding]; other site 426117016957 TPP binding site [chemical binding]; other site 426117016958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426117016959 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 426117016960 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 426117016961 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426117016962 ligand binding site [chemical binding]; other site 426117016963 NAD binding site [chemical binding]; other site 426117016964 dimerization interface [polypeptide binding]; other site 426117016965 catalytic site [active] 426117016966 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 426117016967 putative L-serine binding site [chemical binding]; other site 426117016968 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 426117016969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426117016970 catalytic residue [active] 426117016971 serC leader as predicted by Rfam (RF00517), score 51.09 426117016972 FAD binding domain; Region: FAD_binding_3; pfam01494 426117016973 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117016974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117016975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117016976 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 426117016977 Int/Topo IB signature motif; other site 426117016978 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426117016979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117016980 active site 426117016981 phosphorylation site [posttranslational modification] 426117016982 intermolecular recognition site; other site 426117016983 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 426117016984 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117016985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117016986 ligand binding site [chemical binding]; other site 426117016987 flexible hinge region; other site 426117016988 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117016989 non-specific DNA interactions [nucleotide binding]; other site 426117016990 DNA binding site [nucleotide binding] 426117016991 sequence specific DNA binding site [nucleotide binding]; other site 426117016992 putative cAMP binding site [chemical binding]; other site 426117016993 multiple promoter invertase; Provisional; Region: mpi; PRK13413 426117016994 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117016995 catalytic residues [active] 426117016996 catalytic nucleophile [active] 426117016997 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117016998 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117016999 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117017000 Synaptic Site I dimer interface [polypeptide binding]; other site 426117017001 DNA binding site [nucleotide binding] 426117017002 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426117017003 DNA-binding interface [nucleotide binding]; DNA binding site 426117017004 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426117017005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 426117017006 IS2 transposase TnpB; Reviewed; Region: PRK09409 426117017007 HTH-like domain; Region: HTH_21; pfam13276 426117017008 Integrase core domain; Region: rve; pfam00665 426117017009 Integrase core domain; Region: rve_3; cl15866 426117017010 Helix-turn-helix domain; Region: HTH_28; pfam13518 426117017011 Transposase; Region: HTH_Tnp_1; cl17663 426117017012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426117017013 HTH-like domain; Region: HTH_21; pfam13276 426117017014 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426117017015 Integrase core domain; Region: rve; pfam00665 426117017016 Integrase core domain; Region: rve_3; pfam13683 426117017017 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 426117017018 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017020 active site 426117017021 phosphorylation site [posttranslational modification] 426117017022 intermolecular recognition site; other site 426117017023 dimerization interface [polypeptide binding]; other site 426117017024 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426117017025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426117017026 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 426117017027 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 426117017028 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117017029 Cache domain; Region: Cache_1; pfam02743 426117017030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017031 dimerization interface [polypeptide binding]; other site 426117017032 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117017033 cyclase homology domain; Region: CHD; cd07302 426117017034 nucleotidyl binding site; other site 426117017035 metal binding site [ion binding]; metal-binding site 426117017036 dimer interface [polypeptide binding]; other site 426117017037 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 426117017038 HPP family; Region: HPP; pfam04982 426117017039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 426117017040 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426117017041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117017043 putative substrate translocation pore; other site 426117017044 cell density-dependent motility repressor; Provisional; Region: PRK10082 426117017045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117017046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426117017047 dimerization interface [polypeptide binding]; other site 426117017048 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 426117017049 Aspartase; Region: Aspartase; cd01357 426117017050 active sites [active] 426117017051 tetramer interface [polypeptide binding]; other site 426117017052 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 426117017053 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426117017054 RNA polymerase sigma factor; Provisional; Region: PRK11922 426117017055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117017056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117017057 DNA binding residues [nucleotide binding] 426117017058 Predicted outer membrane protein [Function unknown]; Region: COG3652 426117017059 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 426117017060 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 426117017061 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 426117017062 [4Fe-4S] binding site [ion binding]; other site 426117017063 molybdopterin cofactor binding site; other site 426117017064 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 426117017065 molybdopterin cofactor binding site; other site 426117017066 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117017067 cyclase homology domain; Region: CHD; cd07302 426117017068 nucleotidyl binding site; other site 426117017069 metal binding site [ion binding]; metal-binding site 426117017070 dimer interface [polypeptide binding]; other site 426117017071 Predicted integral membrane protein [Function unknown]; Region: COG5616 426117017072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117017073 TPR motif; other site 426117017074 binding surface 426117017075 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117017076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017077 dimerization interface [polypeptide binding]; other site 426117017078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017079 dimerization interface [polypeptide binding]; other site 426117017080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017081 dimerization interface [polypeptide binding]; other site 426117017082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017083 dimerization interface [polypeptide binding]; other site 426117017084 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117017085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017086 dimerization interface [polypeptide binding]; other site 426117017087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017088 dimerization interface [polypeptide binding]; other site 426117017089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017090 dimerization interface [polypeptide binding]; other site 426117017091 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426117017092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017093 dimerization interface [polypeptide binding]; other site 426117017094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017095 dimerization interface [polypeptide binding]; other site 426117017096 GAF domain; Region: GAF_2; pfam13185 426117017097 GAF domain; Region: GAF_3; pfam13492 426117017098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117017099 dimer interface [polypeptide binding]; other site 426117017100 phosphorylation site [posttranslational modification] 426117017101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017102 ATP binding site [chemical binding]; other site 426117017103 Mg2+ binding site [ion binding]; other site 426117017104 G-X-G motif; other site 426117017105 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017107 active site 426117017108 phosphorylation site [posttranslational modification] 426117017109 intermolecular recognition site; other site 426117017110 dimerization interface [polypeptide binding]; other site 426117017111 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017113 active site 426117017114 phosphorylation site [posttranslational modification] 426117017115 intermolecular recognition site; other site 426117017116 dimerization interface [polypeptide binding]; other site 426117017117 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017119 active site 426117017120 phosphorylation site [posttranslational modification] 426117017121 intermolecular recognition site; other site 426117017122 dimerization interface [polypeptide binding]; other site 426117017123 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017125 active site 426117017126 phosphorylation site [posttranslational modification] 426117017127 intermolecular recognition site; other site 426117017128 dimerization interface [polypeptide binding]; other site 426117017129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117017130 PAS fold; Region: PAS_3; pfam08447 426117017131 putative active site [active] 426117017132 heme pocket [chemical binding]; other site 426117017133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117017134 dimer interface [polypeptide binding]; other site 426117017135 phosphorylation site [posttranslational modification] 426117017136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017137 ATP binding site [chemical binding]; other site 426117017138 Mg2+ binding site [ion binding]; other site 426117017139 G-X-G motif; other site 426117017140 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117017141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017142 active site 426117017143 phosphorylation site [posttranslational modification] 426117017144 intermolecular recognition site; other site 426117017145 dimerization interface [polypeptide binding]; other site 426117017146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017147 ATP binding site [chemical binding]; other site 426117017148 Mg2+ binding site [ion binding]; other site 426117017149 G-X-G motif; other site 426117017150 Response regulator receiver domain; Region: Response_reg; pfam00072 426117017151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017152 active site 426117017153 phosphorylation site [posttranslational modification] 426117017154 intermolecular recognition site; other site 426117017155 dimerization interface [polypeptide binding]; other site 426117017156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117017157 PAS fold; Region: PAS_3; pfam08447 426117017158 putative active site [active] 426117017159 heme pocket [chemical binding]; other site 426117017160 PAS domain S-box; Region: sensory_box; TIGR00229 426117017161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426117017162 putative active site [active] 426117017163 heme pocket [chemical binding]; other site 426117017164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117017165 PAS fold; Region: PAS_3; pfam08447 426117017166 putative active site [active] 426117017167 heme pocket [chemical binding]; other site 426117017168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426117017169 dimer interface [polypeptide binding]; other site 426117017170 phosphorylation site [posttranslational modification] 426117017171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017172 ATP binding site [chemical binding]; other site 426117017173 Mg2+ binding site [ion binding]; other site 426117017174 G-X-G motif; other site 426117017175 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117017176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017177 active site 426117017178 phosphorylation site [posttranslational modification] 426117017179 intermolecular recognition site; other site 426117017180 dimerization interface [polypeptide binding]; other site 426117017181 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117017182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117017183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117017184 DNA binding residues [nucleotide binding] 426117017185 Predicted membrane protein [Function unknown]; Region: COG2855 426117017186 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426117017187 sulfite oxidase; Provisional; Region: PLN00177 426117017188 Moco binding site; other site 426117017189 metal coordination site [ion binding]; other site 426117017190 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426117017191 NAD binding site [chemical binding]; other site 426117017192 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 426117017193 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 426117017194 dimer interface [polypeptide binding]; other site 426117017195 active site 426117017196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426117017197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117017198 Walker A/P-loop; other site 426117017199 ATP binding site [chemical binding]; other site 426117017200 Q-loop/lid; other site 426117017201 ABC transporter signature motif; other site 426117017202 Walker B; other site 426117017203 D-loop; other site 426117017204 H-loop/switch region; other site 426117017205 FtsX-like permease family; Region: FtsX; pfam02687 426117017206 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 426117017207 dimerization interface [polypeptide binding]; other site 426117017208 metal binding site [ion binding]; metal-binding site 426117017209 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 426117017210 Cupin domain; Region: Cupin_2; cl17218 426117017211 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 426117017212 putative hydrolase; Provisional; Region: PRK02113 426117017213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 426117017214 active site 426117017215 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 426117017216 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 426117017217 active site 426117017218 HIGH motif; other site 426117017219 KMSKS motif; other site 426117017220 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 426117017221 tRNA binding surface [nucleotide binding]; other site 426117017222 anticodon binding site; other site 426117017223 Cytochrome c; Region: Cytochrom_C; cl11414 426117017224 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 426117017225 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 426117017226 putative ADP-binding pocket [chemical binding]; other site 426117017227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117017228 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426117017229 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426117017230 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117017231 Walker A/P-loop; other site 426117017232 ATP binding site [chemical binding]; other site 426117017233 Q-loop/lid; other site 426117017234 ABC transporter signature motif; other site 426117017235 Walker B; other site 426117017236 D-loop; other site 426117017237 H-loop/switch region; other site 426117017238 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117017239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426117017240 Walker A/P-loop; other site 426117017241 ATP binding site [chemical binding]; other site 426117017242 Q-loop/lid; other site 426117017243 ABC transporter signature motif; other site 426117017244 Walker B; other site 426117017245 D-loop; other site 426117017246 H-loop/switch region; other site 426117017247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426117017248 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 426117017249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426117017250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426117017251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017252 dimer interface [polypeptide binding]; other site 426117017253 conserved gate region; other site 426117017254 putative PBP binding loops; other site 426117017255 ABC-ATPase subunit interface; other site 426117017256 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 426117017257 microcin C ABC transporter permease; Provisional; Region: PRK15021 426117017258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017259 putative PBP binding loops; other site 426117017260 ABC-ATPase subunit interface; other site 426117017261 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 426117017262 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117017263 translocation protein TolB; Provisional; Region: tolB; PRK04922 426117017264 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426117017265 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 426117017266 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 426117017267 protein binding site [polypeptide binding]; other site 426117017268 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 426117017269 Domain interface; other site 426117017270 Peptide binding site; other site 426117017271 Active site tetrad [active] 426117017272 helicase 45; Provisional; Region: PTZ00424 426117017273 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426117017274 ATP binding site [chemical binding]; other site 426117017275 Mg++ binding site [ion binding]; other site 426117017276 motif III; other site 426117017277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117017278 nucleotide binding region [chemical binding]; other site 426117017279 ATP-binding site [chemical binding]; other site 426117017280 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 426117017281 FMN binding site [chemical binding]; other site 426117017282 substrate binding site [chemical binding]; other site 426117017283 putative catalytic residue [active] 426117017284 benzoate transport; Region: 2A0115; TIGR00895 426117017285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017286 putative substrate translocation pore; other site 426117017287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017288 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426117017289 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 426117017290 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426117017291 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426117017292 ligand binding site [chemical binding]; other site 426117017293 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117017294 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426117017295 TM-ABC transporter signature motif; other site 426117017296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426117017297 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426117017298 TM-ABC transporter signature motif; other site 426117017299 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426117017300 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426117017301 Walker A/P-loop; other site 426117017302 ATP binding site [chemical binding]; other site 426117017303 Q-loop/lid; other site 426117017304 ABC transporter signature motif; other site 426117017305 Walker B; other site 426117017306 D-loop; other site 426117017307 H-loop/switch region; other site 426117017308 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426117017309 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426117017310 Walker A/P-loop; other site 426117017311 ATP binding site [chemical binding]; other site 426117017312 Q-loop/lid; other site 426117017313 ABC transporter signature motif; other site 426117017314 Walker B; other site 426117017315 D-loop; other site 426117017316 H-loop/switch region; other site 426117017317 BolA-like protein; Region: BolA; pfam01722 426117017318 DnaJ domain; Region: DnaJ; pfam00226 426117017319 HSP70 interaction site [polypeptide binding]; other site 426117017320 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 426117017321 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 426117017322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426117017323 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 426117017324 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 426117017325 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 426117017326 metal ion-dependent adhesion site (MIDAS); other site 426117017327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426117017328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117017329 DNA binding site [nucleotide binding] 426117017330 PilZ domain; Region: PilZ; pfam07238 426117017331 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017332 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017333 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017334 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017335 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017336 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426117017337 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 426117017338 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117017339 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 426117017340 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 426117017341 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117017342 Walker A motif; other site 426117017343 ATP binding site [chemical binding]; other site 426117017344 Walker B motif; other site 426117017345 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 426117017346 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426117017347 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 426117017348 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117017349 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 426117017350 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426117017351 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 426117017352 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426117017353 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426117017354 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 426117017355 Flagellar protein FlaF; Region: FlaF; cl11454 426117017356 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 426117017357 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 426117017358 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 426117017359 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781 426117017360 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 426117017361 FHIPEP family; Region: FHIPEP; pfam00771 426117017362 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780 426117017363 Rod binding protein; Region: Rod-binding; pfam10135 426117017364 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 426117017365 thiamine pyrophosphate protein; Validated; Region: PRK08199 426117017366 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426117017367 PYR/PP interface [polypeptide binding]; other site 426117017368 dimer interface [polypeptide binding]; other site 426117017369 TPP binding site [chemical binding]; other site 426117017370 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426117017371 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 426117017372 TPP-binding site [chemical binding]; other site 426117017373 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426117017374 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426117017375 acyl-activating enzyme (AAE) consensus motif; other site 426117017376 AMP binding site [chemical binding]; other site 426117017377 active site 426117017378 CoA binding site [chemical binding]; other site 426117017379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426117017380 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426117017381 NAD(P) binding site [chemical binding]; other site 426117017382 active site 426117017383 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426117017384 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 426117017385 glutathione s-transferase; Provisional; Region: PTZ00057 426117017386 GSH binding site (G-site) [chemical binding]; other site 426117017387 C-terminal domain interface [polypeptide binding]; other site 426117017388 dimer interface [polypeptide binding]; other site 426117017389 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 426117017390 dimer interface [polypeptide binding]; other site 426117017391 N-terminal domain interface [polypeptide binding]; other site 426117017392 substrate binding pocket (H-site) [chemical binding]; other site 426117017393 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 426117017394 muropeptide transporter; Reviewed; Region: ampG; PRK11902 426117017395 muropeptide transporter; Validated; Region: ampG; cl17669 426117017396 hypothetical protein; Provisional; Region: PRK13559 426117017397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426117017398 putative active site [active] 426117017399 heme pocket [chemical binding]; other site 426117017400 Histidine kinase; Region: HisKA_2; pfam07568 426117017401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017402 ATP binding site [chemical binding]; other site 426117017403 Mg2+ binding site [ion binding]; other site 426117017404 G-X-G motif; other site 426117017405 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 426117017406 MutS domain I; Region: MutS_I; pfam01624 426117017407 MutS domain II; Region: MutS_II; pfam05188 426117017408 MutS domain III; Region: MutS_III; pfam05192 426117017409 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 426117017410 Walker A/P-loop; other site 426117017411 ATP binding site [chemical binding]; other site 426117017412 Q-loop/lid; other site 426117017413 ABC transporter signature motif; other site 426117017414 Walker B; other site 426117017415 D-loop; other site 426117017416 H-loop/switch region; other site 426117017417 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 426117017418 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 426117017419 dimerization interface [polypeptide binding]; other site 426117017420 domain crossover interface; other site 426117017421 redox-dependent activation switch; other site 426117017422 ornithine carbamoyltransferase; Provisional; Region: PRK00779 426117017423 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426117017424 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426117017425 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 426117017426 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426117017427 inhibitor-cofactor binding pocket; inhibition site 426117017428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117017429 catalytic residue [active] 426117017430 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 426117017431 homotrimer interaction site [polypeptide binding]; other site 426117017432 putative active site [active] 426117017433 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 426117017434 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426117017435 active site 426117017436 catalytic site [active] 426117017437 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 426117017438 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 426117017439 trimer interface [polypeptide binding]; other site 426117017440 active site 426117017441 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 426117017442 trimer interface [polypeptide binding]; other site 426117017443 active site 426117017444 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 426117017445 acetylornithine deacetylase; Provisional; Region: PRK07522 426117017446 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 426117017447 metal binding site [ion binding]; metal-binding site 426117017448 putative dimer interface [polypeptide binding]; other site 426117017449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117017450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117017451 metal binding site [ion binding]; metal-binding site 426117017452 active site 426117017453 I-site; other site 426117017454 LysE type translocator; Region: LysE; cl00565 426117017455 PRC-barrel domain; Region: PRC; pfam05239 426117017456 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 426117017457 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426117017458 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426117017459 putative NAD(P) binding site [chemical binding]; other site 426117017460 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 426117017461 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 426117017462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426117017463 ATP binding site [chemical binding]; other site 426117017464 putative Mg++ binding site [ion binding]; other site 426117017465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426117017466 nucleotide binding region [chemical binding]; other site 426117017467 ATP-binding site [chemical binding]; other site 426117017468 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 426117017469 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 426117017470 CMP-binding site; other site 426117017471 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 426117017472 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 426117017473 hinge; other site 426117017474 active site 426117017475 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 426117017476 TIGR02300 family protein; Region: FYDLN_acid 426117017477 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 426117017478 homodimer interface [polypeptide binding]; other site 426117017479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117017480 catalytic residue [active] 426117017481 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 426117017482 glycerate dehydrogenase; Provisional; Region: PRK06487 426117017483 putative ligand binding site [chemical binding]; other site 426117017484 putative NAD binding site [chemical binding]; other site 426117017485 catalytic site [active] 426117017486 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 426117017487 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 426117017488 NADP binding site [chemical binding]; other site 426117017489 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 426117017490 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 426117017491 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 426117017492 CoA-ligase; Region: Ligase_CoA; pfam00549 426117017493 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 426117017494 CoA binding domain; Region: CoA_binding; pfam02629 426117017495 CoA-ligase; Region: Ligase_CoA; pfam00549 426117017496 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 426117017497 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 426117017498 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426117017499 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426117017500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017501 putative substrate translocation pore; other site 426117017502 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426117017503 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117017504 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117017505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426117017506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117017507 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 426117017508 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 426117017509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 426117017510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 426117017511 ATP binding site [chemical binding]; other site 426117017512 Mg2+ binding site [ion binding]; other site 426117017513 G-X-G motif; other site 426117017514 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 426117017515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017516 Mg2+ binding site [ion binding]; other site 426117017517 G-X-G motif; other site 426117017518 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 426117017519 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 426117017520 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 426117017521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426117017522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117017523 ligand binding site [chemical binding]; other site 426117017524 flexible hinge region; other site 426117017525 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426117017526 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 426117017527 MgtC family; Region: MgtC; pfam02308 426117017528 EamA-like transporter family; Region: EamA; pfam00892 426117017529 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426117017530 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 426117017531 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426117017532 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 426117017533 SIR2-like domain; Region: SIR2_2; pfam13289 426117017534 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426117017535 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117017536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117017537 ABC transporter; Region: ABC_tran_2; pfam12848 426117017538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426117017539 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426117017540 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426117017541 Peptidase family M23; Region: Peptidase_M23; pfam01551 426117017542 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 426117017543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117017544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426117017545 S-adenosylmethionine binding site [chemical binding]; other site 426117017546 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 426117017547 seryl-tRNA synthetase; Provisional; Region: PRK05431 426117017548 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 426117017549 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 426117017550 dimer interface [polypeptide binding]; other site 426117017551 active site 426117017552 motif 1; other site 426117017553 motif 2; other site 426117017554 motif 3; other site 426117017555 hypothetical protein; Validated; Region: PRK00110 426117017556 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117017557 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 426117017558 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 426117017559 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 426117017560 trigger factor; Provisional; Region: tig; PRK01490 426117017561 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 426117017562 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 426117017563 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 426117017564 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 426117017565 oligomer interface [polypeptide binding]; other site 426117017566 active site residues [active] 426117017567 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 426117017568 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 426117017569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117017570 Walker A motif; other site 426117017571 ATP binding site [chemical binding]; other site 426117017572 Walker B motif; other site 426117017573 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426117017574 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 426117017575 Found in ATP-dependent protease La (LON); Region: LON; smart00464 426117017576 Found in ATP-dependent protease La (LON); Region: LON; smart00464 426117017577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117017578 Walker A motif; other site 426117017579 ATP binding site [chemical binding]; other site 426117017580 Walker B motif; other site 426117017581 arginine finger; other site 426117017582 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 426117017583 Uncharacterized conserved protein [Function unknown]; Region: COG0062 426117017584 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 426117017585 putative substrate binding site [chemical binding]; other site 426117017586 putative ATP binding site [chemical binding]; other site 426117017587 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 426117017588 Nitrogen regulatory protein P-II; Region: P-II; smart00938 426117017589 glutamine synthetase; Provisional; Region: glnA; PRK09469 426117017590 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426117017591 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426117017592 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426117017593 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426117017594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117017595 dimer interface [polypeptide binding]; other site 426117017596 putative CheW interface [polypeptide binding]; other site 426117017597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117017599 putative substrate translocation pore; other site 426117017600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017601 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426117017602 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117017603 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117017604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426117017605 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 426117017606 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426117017607 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426117017608 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 426117017609 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 426117017610 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 426117017611 active site 426117017612 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 426117017613 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 426117017614 Ligand Binding Site [chemical binding]; other site 426117017615 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 426117017616 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 426117017617 active site 426117017618 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 426117017619 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 426117017620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017621 metabolite-proton symporter; Region: 2A0106; TIGR00883 426117017622 putative substrate translocation pore; other site 426117017623 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 426117017624 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426117017625 active site 426117017626 catalytic site [active] 426117017627 substrate binding site [chemical binding]; other site 426117017628 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117017629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426117017630 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426117017631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117017632 dimer interface [polypeptide binding]; other site 426117017633 putative CheW interface [polypeptide binding]; other site 426117017634 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 426117017635 ligand binding site; other site 426117017636 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 426117017637 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 426117017638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426117017639 macrolide transporter subunit MacA; Provisional; Region: PRK11578 426117017640 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426117017641 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117017642 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 426117017643 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426117017644 Walker A/P-loop; other site 426117017645 ATP binding site [chemical binding]; other site 426117017646 Q-loop/lid; other site 426117017647 ABC transporter signature motif; other site 426117017648 Walker B; other site 426117017649 D-loop; other site 426117017650 H-loop/switch region; other site 426117017651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426117017652 FtsX-like permease family; Region: FtsX; pfam02687 426117017653 Outer membrane efflux protein; Region: OEP; pfam02321 426117017654 GTPase Era; Reviewed; Region: era; PRK00089 426117017655 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 426117017656 G1 box; other site 426117017657 GTP/Mg2+ binding site [chemical binding]; other site 426117017658 Switch I region; other site 426117017659 G2 box; other site 426117017660 Switch II region; other site 426117017661 G3 box; other site 426117017662 G4 box; other site 426117017663 G5 box; other site 426117017664 KH domain; Region: KH_2; pfam07650 426117017665 ribonuclease III; Reviewed; Region: rnc; PRK00102 426117017666 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 426117017667 dimerization interface [polypeptide binding]; other site 426117017668 active site 426117017669 metal binding site [ion binding]; metal-binding site 426117017670 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 426117017671 dsRNA binding site [nucleotide binding]; other site 426117017672 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 426117017673 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426117017674 Catalytic site [active] 426117017675 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426117017676 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 426117017677 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 426117017678 active site 426117017679 hydrophilic channel; other site 426117017680 dimerization interface [polypeptide binding]; other site 426117017681 catalytic residues [active] 426117017682 active site lid [active] 426117017683 PRC-barrel domain; Region: PRC; pfam05239 426117017684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117017685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117017686 putative substrate translocation pore; other site 426117017687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426117017688 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426117017689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426117017690 Walker A/P-loop; other site 426117017691 ATP binding site [chemical binding]; other site 426117017692 Q-loop/lid; other site 426117017693 ABC transporter signature motif; other site 426117017694 Walker B; other site 426117017695 D-loop; other site 426117017696 H-loop/switch region; other site 426117017697 Domain of unknown function (DUF4130; Region: DUF4130; pfam13566 426117017698 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 426117017699 Fe-S cluster binding site [ion binding]; other site 426117017700 active site 426117017701 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 426117017702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426117017703 FeS/SAM binding site; other site 426117017704 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426117017705 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426117017706 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 426117017707 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 426117017708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426117017709 ATP binding site [chemical binding]; other site 426117017710 Mg2+ binding site [ion binding]; other site 426117017711 G-X-G motif; other site 426117017712 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 426117017713 ATP binding site [chemical binding]; other site 426117017714 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 426117017715 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 426117017716 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426117017717 NAD(P) binding site [chemical binding]; other site 426117017718 active site 426117017719 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 426117017720 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 426117017721 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 426117017722 DsbD alpha interface [polypeptide binding]; other site 426117017723 catalytic residues [active] 426117017724 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 426117017725 putative catalytic residue [active] 426117017726 Protein of unknown function (DUF429); Region: DUF429; cl12046 426117017727 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 426117017728 nudix motif; other site 426117017729 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 426117017730 active site clefts [active] 426117017731 zinc binding site [ion binding]; other site 426117017732 dimer interface [polypeptide binding]; other site 426117017733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 426117017734 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 426117017735 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 426117017736 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 426117017737 gamma subunit interface [polypeptide binding]; other site 426117017738 epsilon subunit interface [polypeptide binding]; other site 426117017739 LBP interface [polypeptide binding]; other site 426117017740 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 426117017741 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426117017742 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 426117017743 alpha subunit interaction interface [polypeptide binding]; other site 426117017744 Walker A motif; other site 426117017745 ATP binding site [chemical binding]; other site 426117017746 Walker B motif; other site 426117017747 inhibitor binding site; inhibition site 426117017748 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426117017749 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 426117017750 core domain interface [polypeptide binding]; other site 426117017751 delta subunit interface [polypeptide binding]; other site 426117017752 epsilon subunit interface [polypeptide binding]; other site 426117017753 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 426117017754 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426117017755 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 426117017756 beta subunit interaction interface [polypeptide binding]; other site 426117017757 Walker A motif; other site 426117017758 ATP binding site [chemical binding]; other site 426117017759 Walker B motif; other site 426117017760 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426117017761 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 426117017762 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 426117017763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117017764 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426117017765 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 426117017766 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 426117017767 putative catalytic residue [active] 426117017768 argininosuccinate synthase; Provisional; Region: PRK13820 426117017769 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 426117017770 ANP binding site [chemical binding]; other site 426117017771 Substrate Binding Site II [chemical binding]; other site 426117017772 Substrate Binding Site I [chemical binding]; other site 426117017773 Transglycosylase; Region: Transgly; cl17702 426117017774 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426117017775 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426117017776 substrate binding pocket [chemical binding]; other site 426117017777 chain length determination region; other site 426117017778 substrate-Mg2+ binding site; other site 426117017779 catalytic residues [active] 426117017780 aspartate-rich region 1; other site 426117017781 active site lid residues [active] 426117017782 aspartate-rich region 2; other site 426117017783 tartrate dehydrogenase; Region: TTC; TIGR02089 426117017784 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 426117017785 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426117017786 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 426117017787 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426117017788 phosphate binding site [ion binding]; other site 426117017789 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426117017790 short chain dehydrogenase; Provisional; Region: PRK06197 426117017791 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 426117017792 putative NAD(P) binding site [chemical binding]; other site 426117017793 active site 426117017794 Protein of unknown function (DUF808); Region: DUF808; cl01002 426117017795 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 426117017796 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 426117017797 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 426117017798 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426117017799 Cytochrome P450; Region: p450; cl12078 426117017800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017801 putative PBP binding loops; other site 426117017802 dimer interface [polypeptide binding]; other site 426117017803 ABC-ATPase subunit interface; other site 426117017804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426117017805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017806 dimer interface [polypeptide binding]; other site 426117017807 conserved gate region; other site 426117017808 putative PBP binding loops; other site 426117017809 ABC-ATPase subunit interface; other site 426117017810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426117017811 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426117017812 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 426117017813 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 426117017814 active site 426117017815 metal binding site [ion binding]; metal-binding site 426117017816 hexamer interface [polypeptide binding]; other site 426117017817 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 426117017818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117017819 binding surface 426117017820 TPR motif; other site 426117017821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117017822 binding surface 426117017823 TPR motif; other site 426117017824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426117017825 binding surface 426117017826 TPR motif; other site 426117017827 TPR repeat; Region: TPR_11; pfam13414 426117017828 Caspase domain; Region: Peptidase_C14; pfam00656 426117017829 substrate pocket [chemical binding]; other site 426117017830 active site 426117017831 dimer interface [polypeptide binding]; other site 426117017832 proteolytic cleavage site; other site 426117017833 Autotransporter beta-domain; Region: Autotransporter; cl17461 426117017834 TraB family; Region: TraB; cl12050 426117017835 TraB family; Region: TraB; pfam01963 426117017836 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426117017837 HlyD family secretion protein; Region: HlyD_3; pfam13437 426117017838 ribonuclease R; Region: RNase_R; TIGR02063 426117017839 RNB domain; Region: RNB; pfam00773 426117017840 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 426117017841 RNA binding site [nucleotide binding]; other site 426117017842 Protein of unknown function (DUF983); Region: DUF983; cl02211 426117017843 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 426117017844 nudix motif; other site 426117017845 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426117017846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426117017847 dimerization interface [polypeptide binding]; other site 426117017848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117017849 putative CheW interface [polypeptide binding]; other site 426117017850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426117017851 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 426117017852 response regulator PleD; Reviewed; Region: pleD; PRK09581 426117017853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017854 active site 426117017855 phosphorylation site [posttranslational modification] 426117017856 intermolecular recognition site; other site 426117017857 dimerization interface [polypeptide binding]; other site 426117017858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017859 active site 426117017860 phosphorylation site [posttranslational modification] 426117017861 intermolecular recognition site; other site 426117017862 dimerization interface [polypeptide binding]; other site 426117017863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117017864 metal binding site [ion binding]; metal-binding site 426117017865 active site 426117017866 I-site; other site 426117017867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426117017868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017869 active site 426117017870 phosphorylation site [posttranslational modification] 426117017871 intermolecular recognition site; other site 426117017872 dimerization interface [polypeptide binding]; other site 426117017873 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 426117017874 DNA polymerase IV; Provisional; Region: PRK02794 426117017875 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 426117017876 active site 426117017877 DNA binding site [nucleotide binding] 426117017878 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 426117017879 GcrA cell cycle regulator; Region: GcrA; cl11564 426117017880 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 426117017881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117017882 active site 426117017883 phosphorylation site [posttranslational modification] 426117017884 intermolecular recognition site; other site 426117017885 dimerization interface [polypeptide binding]; other site 426117017886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426117017887 DNA binding site [nucleotide binding] 426117017888 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 426117017889 PhoU domain; Region: PhoU; pfam01895 426117017890 PhoU domain; Region: PhoU; pfam01895 426117017891 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 426117017892 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 426117017893 Walker A/P-loop; other site 426117017894 ATP binding site [chemical binding]; other site 426117017895 Q-loop/lid; other site 426117017896 ABC transporter signature motif; other site 426117017897 Walker B; other site 426117017898 D-loop; other site 426117017899 H-loop/switch region; other site 426117017900 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 426117017901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017902 dimer interface [polypeptide binding]; other site 426117017903 conserved gate region; other site 426117017904 putative PBP binding loops; other site 426117017905 ABC-ATPase subunit interface; other site 426117017906 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 426117017907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426117017908 dimer interface [polypeptide binding]; other site 426117017909 conserved gate region; other site 426117017910 putative PBP binding loops; other site 426117017911 ABC-ATPase subunit interface; other site 426117017912 PBP superfamily domain; Region: PBP_like_2; cl17296 426117017913 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117017914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117017915 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117017916 DNA binding residues [nucleotide binding] 426117017917 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 426117017918 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426117017919 Walker A/P-loop; other site 426117017920 ATP binding site [chemical binding]; other site 426117017921 Q-loop/lid; other site 426117017922 ABC transporter signature motif; other site 426117017923 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426117017924 ABC transporter signature motif; other site 426117017925 Walker B; other site 426117017926 D-loop; other site 426117017927 H-loop/switch region; other site 426117017928 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 426117017929 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 426117017930 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 426117017931 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 426117017932 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 426117017933 nucleotide binding site [chemical binding]; other site 426117017934 SulA interaction site; other site 426117017935 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 426117017936 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 426117017937 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 426117017938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 426117017939 nucleotide binding site [chemical binding]; other site 426117017940 Cell division protein FtsA; Region: FtsA; pfam14450 426117017941 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 426117017942 Cell division protein FtsQ; Region: FtsQ; pfam03799 426117017943 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 426117017944 FAD binding domain; Region: FAD_binding_4; pfam01565 426117017945 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 426117017946 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 426117017947 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426117017948 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426117017949 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426117017950 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 426117017951 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 426117017952 active site 426117017953 homodimer interface [polypeptide binding]; other site 426117017954 cell division protein FtsW; Region: ftsW; TIGR02614 426117017955 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 426117017956 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 426117017957 putative active site [active] 426117017958 catalytic residue [active] 426117017959 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 426117017960 active site 426117017961 dimer interface [polypeptide binding]; other site 426117017962 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 426117017963 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 426117017964 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426117017965 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 426117017966 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 426117017967 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 426117017968 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 426117017969 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 426117017970 putative active site [active] 426117017971 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 426117017972 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426117017973 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 426117017974 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 426117017975 FixH; Region: FixH; pfam05751 426117017976 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426117017977 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426117017978 metal-binding site [ion binding] 426117017979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426117017980 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 426117017981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426117017982 Zn2+ binding site [ion binding]; other site 426117017983 Mg2+ binding site [ion binding]; other site 426117017984 LexA repressor; Validated; Region: PRK00215 426117017985 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 426117017986 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426117017987 Catalytic site [active] 426117017988 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 426117017989 zinc binding site [ion binding]; other site 426117017990 putative ligand binding site [chemical binding]; other site 426117017991 integrase; Provisional; Region: PRK09692 426117017992 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 426117017993 active site 426117017994 Int/Topo IB signature motif; other site 426117017995 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 426117017996 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 426117017997 nucleotide binding site [chemical binding]; other site 426117017998 AAA domain; Region: AAA_25; pfam13481 426117017999 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426117018000 Walker A motif; other site 426117018001 ATP binding site [chemical binding]; other site 426117018002 Walker B motif; other site 426117018003 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 426117018004 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117018005 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117018006 Integrase core domain; Region: rve; pfam00665 426117018007 Transposase; Region: HTH_Tnp_1; cl17663 426117018008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 426117018009 Transposase; Region: DDE_Tnp_ISL3; pfam01610 426117018010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426117018011 DDE domain; Region: DDE_Tnp_IS240; pfam13610 426117018012 Integrase core domain; Region: rve; pfam00665 426117018013 CHRD domain; Region: CHRD; pfam07452 426117018014 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117018015 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117018016 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117018017 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117018018 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117018019 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426117018020 catalytic residues [active] 426117018021 catalytic nucleophile [active] 426117018022 Presynaptic Site I dimer interface [polypeptide binding]; other site 426117018023 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426117018024 Synaptic Flat tetramer interface [polypeptide binding]; other site 426117018025 Synaptic Site I dimer interface [polypeptide binding]; other site 426117018026 Uncharacterized conserved protein [Function unknown]; Region: COG1262 426117018027 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 426117018028 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 426117018029 Sulfatase; Region: Sulfatase; pfam00884 426117018030 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426117018031 Uncharacterized conserved protein [Function unknown]; Region: COG5361 426117018032 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 426117018033 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 426117018034 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426117018035 MULE transposase domain; Region: MULE; pfam10551 426117018036 salicylate hydroxylase; Provisional; Region: PRK08163 426117018037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117018038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 426117018039 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 426117018040 active site 426117018041 hypothetical protein; Reviewed; Region: PRK00024 426117018042 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 426117018043 MPN+ (JAMM) motif; other site 426117018044 Zinc-binding site [ion binding]; other site 426117018045 Uncharacterized conserved protein [Function unknown]; Region: COG2308 426117018046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 426117018047 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 426117018048 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426117018049 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426117018050 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426117018051 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 426117018052 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 426117018053 active site 426117018054 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426117018055 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 426117018056 ThiS interaction site; other site 426117018057 putative active site [active] 426117018058 tetramer interface [polypeptide binding]; other site 426117018059 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 426117018060 thiS-thiF/thiG interaction site; other site 426117018061 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 426117018062 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426117018063 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117018064 cyclase homology domain; Region: CHD; cd07302 426117018065 nucleotidyl binding site; other site 426117018066 metal binding site [ion binding]; metal-binding site 426117018067 dimer interface [polypeptide binding]; other site 426117018068 Hint domain; Region: Hint_2; pfam13403 426117018069 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 426117018070 active site 426117018071 Hint domain; Region: Hint_2; pfam13403 426117018072 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 426117018073 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 426117018074 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 426117018075 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 426117018076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117018077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 426117018078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117018079 DNA binding residues [nucleotide binding] 426117018080 DNA primase, catalytic core; Region: dnaG; TIGR01391 426117018081 CHC2 zinc finger; Region: zf-CHC2; pfam01807 426117018082 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 426117018083 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 426117018084 active site 426117018085 metal binding site [ion binding]; metal-binding site 426117018086 interdomain interaction site; other site 426117018087 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 426117018088 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 426117018089 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 426117018090 catalytic triad [active] 426117018091 Transglycosylase; Region: Transgly; pfam00912 426117018092 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426117018093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426117018094 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 426117018095 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 426117018096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426117018097 Histidine kinase; Region: HisKA_3; pfam07730 426117018098 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 426117018099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426117018100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426117018101 active site 426117018102 phosphorylation site [posttranslational modification] 426117018103 intermolecular recognition site; other site 426117018104 dimerization interface [polypeptide binding]; other site 426117018105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426117018106 DNA binding residues [nucleotide binding] 426117018107 dimerization interface [polypeptide binding]; other site 426117018108 pyruvate kinase; Provisional; Region: PRK06247 426117018109 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426117018110 domain interfaces; other site 426117018111 active site 426117018112 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 426117018113 tartrate dehydrogenase; Region: TTC; TIGR02089 426117018114 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117018115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117018116 putative substrate translocation pore; other site 426117018117 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117018118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117018119 DNA-binding site [nucleotide binding]; DNA binding site 426117018120 FCD domain; Region: FCD; pfam07729 426117018121 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426117018122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426117018123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426117018124 metal binding site [ion binding]; metal-binding site 426117018125 active site 426117018126 I-site; other site 426117018127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426117018128 pantothenate kinase; Provisional; Region: PRK05439 426117018129 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 426117018130 ATP-binding site [chemical binding]; other site 426117018131 CoA-binding site [chemical binding]; other site 426117018132 Mg2+-binding site [ion binding]; other site 426117018133 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 426117018134 metal binding site [ion binding]; metal-binding site 426117018135 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 426117018136 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 426117018137 substrate binding site [chemical binding]; other site 426117018138 glutamase interaction surface [polypeptide binding]; other site 426117018139 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 426117018140 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 426117018141 catalytic residues [active] 426117018142 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 426117018143 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 426117018144 putative active site [active] 426117018145 oxyanion strand; other site 426117018146 catalytic triad [active] 426117018147 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 426117018148 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 426117018149 putative active site pocket [active] 426117018150 4-fold oligomerization interface [polypeptide binding]; other site 426117018151 metal binding residues [ion binding]; metal-binding site 426117018152 3-fold/trimer interface [polypeptide binding]; other site 426117018153 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 426117018154 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 426117018155 cytochrome b; Provisional; Region: CYTB; MTH00191 426117018156 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 426117018157 Qi binding site; other site 426117018158 intrachain domain interface; other site 426117018159 interchain domain interface [polypeptide binding]; other site 426117018160 heme bH binding site [chemical binding]; other site 426117018161 heme bL binding site [chemical binding]; other site 426117018162 Qo binding site; other site 426117018163 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 426117018164 interchain domain interface [polypeptide binding]; other site 426117018165 intrachain domain interface; other site 426117018166 Qi binding site; other site 426117018167 Qo binding site; other site 426117018168 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 426117018169 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 426117018170 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 426117018171 [2Fe-2S] cluster binding site [ion binding]; other site 426117018172 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426117018173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426117018174 putative substrate translocation pore; other site 426117018175 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 426117018176 homopentamer interface [polypeptide binding]; other site 426117018177 active site 426117018178 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 426117018179 putative RNA binding site [nucleotide binding]; other site 426117018180 thiamine monophosphate kinase; Provisional; Region: PRK05731 426117018181 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 426117018182 ATP binding site [chemical binding]; other site 426117018183 dimerization interface [polypeptide binding]; other site 426117018184 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 426117018185 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 426117018186 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426117018187 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 426117018188 putative [4Fe-4S] binding site [ion binding]; other site 426117018189 putative molybdopterin cofactor binding site [chemical binding]; other site 426117018190 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 426117018191 putative molybdopterin cofactor binding site; other site 426117018192 aspartate aminotransferase; Provisional; Region: PRK06108 426117018193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426117018194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117018195 homodimer interface [polypeptide binding]; other site 426117018196 catalytic residue [active] 426117018197 glycogen branching enzyme; Provisional; Region: PRK05402 426117018198 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 426117018199 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 426117018200 active site 426117018201 catalytic site [active] 426117018202 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 426117018203 trehalose synthase; Region: treS_nterm; TIGR02456 426117018204 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 426117018205 active site 426117018206 catalytic site [active] 426117018207 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 426117018208 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 426117018209 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 426117018210 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 426117018211 active site 426117018212 catalytic site [active] 426117018213 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 426117018214 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 426117018215 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 426117018216 active site 426117018217 homodimer interface [polypeptide binding]; other site 426117018218 catalytic site [active] 426117018219 acceptor binding site [chemical binding]; other site 426117018220 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 426117018221 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 426117018222 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 426117018223 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 426117018224 active site 426117018225 catalytic site [active] 426117018226 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 426117018227 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 426117018228 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 426117018229 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 426117018230 catalytic site [active] 426117018231 active site 426117018232 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426117018233 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 426117018234 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 426117018235 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 426117018236 active site 426117018237 catalytic site [active] 426117018238 Protein of unknown function (DUF779); Region: DUF779; cl01432 426117018239 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 426117018240 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426117018241 NAD(P) binding site [chemical binding]; other site 426117018242 catalytic residues [active] 426117018243 GAF domain; Region: GAF; pfam01590 426117018244 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117018245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117018246 Walker A motif; other site 426117018247 ATP binding site [chemical binding]; other site 426117018248 Walker B motif; other site 426117018249 arginine finger; other site 426117018250 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426117018251 CHASE3 domain; Region: CHASE3; pfam05227 426117018252 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426117018253 cyclase homology domain; Region: CHD; cd07302 426117018254 nucleotidyl binding site; other site 426117018255 metal binding site [ion binding]; metal-binding site 426117018256 dimer interface [polypeptide binding]; other site 426117018257 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 426117018258 UV-endonuclease UvdE; Region: UvdE; cl10036 426117018259 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 426117018260 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117018261 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 426117018262 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 426117018263 active site 426117018264 homotetramer interface [polypeptide binding]; other site 426117018265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426117018266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426117018267 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 426117018268 putative effector binding pocket; other site 426117018269 putative dimerization interface [polypeptide binding]; other site 426117018270 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426117018271 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426117018272 Beta-lactamase; Region: Beta-lactamase; pfam00144 426117018273 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 426117018274 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 426117018275 Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072 426117018276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117018277 Walker A motif; other site 426117018278 ATP binding site [chemical binding]; other site 426117018279 Walker B motif; other site 426117018280 arginine finger; other site 426117018281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117018282 Walker A motif; other site 426117018283 ATP binding site [chemical binding]; other site 426117018284 Walker B motif; other site 426117018285 arginine finger; other site 426117018286 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426117018287 active site 426117018288 metal binding site [ion binding]; metal-binding site 426117018289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426117018290 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 426117018291 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 426117018292 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 426117018293 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 426117018294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117018295 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 426117018296 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 426117018297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426117018298 substrate binding site [chemical binding]; other site 426117018299 oxyanion hole (OAH) forming residues; other site 426117018300 trimer interface [polypeptide binding]; other site 426117018301 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 426117018302 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 426117018303 dimer interface [polypeptide binding]; other site 426117018304 allosteric magnesium binding site [ion binding]; other site 426117018305 active site 426117018306 aspartate-rich active site metal binding site; other site 426117018307 Schiff base residues; other site 426117018308 threonine dehydratase; Provisional; Region: PRK07334 426117018309 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426117018310 tetramer interface [polypeptide binding]; other site 426117018311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117018312 catalytic residue [active] 426117018313 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 426117018314 RDD family; Region: RDD; pfam06271 426117018315 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 426117018316 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 426117018317 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 426117018318 stage V sporulation protein K; Region: spore_V_K; TIGR02881 426117018319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117018320 Walker A motif; other site 426117018321 ATP binding site [chemical binding]; other site 426117018322 Walker B motif; other site 426117018323 arginine finger; other site 426117018324 adenylosuccinate lyase; Provisional; Region: PRK07492 426117018325 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 426117018326 tetramer interface [polypeptide binding]; other site 426117018327 active site 426117018328 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426117018329 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 426117018330 homodimer interface [polypeptide binding]; other site 426117018331 substrate-cofactor binding pocket; other site 426117018332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426117018333 catalytic residue [active] 426117018334 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 426117018335 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 426117018336 GDP-binding site [chemical binding]; other site 426117018337 ACT binding site; other site 426117018338 IMP binding site; other site 426117018339 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 426117018340 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 426117018341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117018342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117018343 DNA binding residues [nucleotide binding] 426117018344 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426117018345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426117018346 RNA binding surface [nucleotide binding]; other site 426117018347 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426117018348 active site 426117018349 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426117018350 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426117018351 Cupin domain; Region: Cupin_2; pfam07883 426117018352 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426117018353 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 426117018354 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 426117018355 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 426117018356 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 426117018357 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 426117018358 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 426117018359 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 426117018360 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 426117018361 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 426117018362 Coenzyme A transferase; Region: CoA_trans; cl17247 426117018363 Malonate transporter MadL subunit; Region: MadL; cl04273 426117018364 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 426117018365 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426117018366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426117018367 DNA-binding site [nucleotide binding]; DNA binding site 426117018368 FCD domain; Region: FCD; pfam07729 426117018369 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 426117018370 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 426117018371 Predicted transcriptional regulators [Transcription]; Region: COG1733 426117018372 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426117018373 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426117018374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117018375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117018376 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426117018377 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 426117018378 hydrophobic ligand binding site; other site 426117018379 RibD C-terminal domain; Region: RibD_C; cl17279 426117018380 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 426117018381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426117018382 active site 426117018383 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 426117018384 benzoate transport; Region: 2A0115; TIGR00895 426117018385 phenol 2-monooxygenase; Provisional; Region: PRK08294 426117018386 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426117018387 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 426117018388 dimer interface [polypeptide binding]; other site 426117018389 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426117018390 MarR family; Region: MarR; pfam01047 426117018391 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117018392 Homeodomain-like domain; Region: HTH_23; pfam13384 426117018393 Winged helix-turn helix; Region: HTH_29; pfam13551 426117018394 Homeodomain-like domain; Region: HTH_32; pfam13565 426117018395 RNA polymerase sigma factor; Provisional; Region: PRK12547 426117018396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426117018397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426117018398 DNA binding residues [nucleotide binding] 426117018399 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117018400 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 426117018401 catalytic residues [active] 426117018402 catalytic nucleophile [active] 426117018403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426117018404 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426117018405 PAS fold; Region: PAS_3; pfam08447 426117018406 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426117018407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426117018408 HWE histidine kinase; Region: HWE_HK; pfam07536 426117018409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117018410 PAS domain; Region: PAS_9; pfam13426 426117018411 putative active site [active] 426117018412 heme pocket [chemical binding]; other site 426117018413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426117018414 PAS fold; Region: PAS_3; pfam08447 426117018415 putative active site [active] 426117018416 heme pocket [chemical binding]; other site 426117018417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426117018418 dimer interface [polypeptide binding]; other site 426117018419 putative CheW interface [polypeptide binding]; other site 426117018420 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426117018421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 426117018422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 426117018423 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426117018424 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426117018425 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426117018426 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426117018427 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426117018428 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426117018429 catalytic residues [active] 426117018430 catalytic nucleophile [active] 426117018431 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117018432 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426117018433 Integrase core domain; Region: rve; pfam00665 426117018434 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426117018435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426117018436 Walker A motif; other site 426117018437 ATP binding site [chemical binding]; other site 426117018438 Walker B motif; other site 426117018439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 426117018440 Helix-turn-helix domain; Region: HTH_38; pfam13936 426117018441 Integrase core domain; Region: rve; pfam00665 426117018442 Helix-turn-helix domain; Region: HTH_17; pfam12728 426117018443 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426117018444 active site 426117018445 catalytic residues [active] 426117018446 DNA binding site [nucleotide binding] 426117018447 Int/Topo IB signature motif; other site 426117018448 Uncharacterized conserved protein [Function unknown]; Region: COG4274 426117018449 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426117018450 ligand binding site [chemical binding]; other site 426117018451 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426117018452 putative switch regulator; other site 426117018453 non-specific DNA interactions [nucleotide binding]; other site 426117018454 DNA binding site [nucleotide binding] 426117018455 sequence specific DNA binding site [nucleotide binding]; other site 426117018456 putative cAMP binding site [chemical binding]; other site 426117018457 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426117018458 Cytochrome c; Region: Cytochrom_C; pfam00034 426117018459 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 426117018460 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426117018461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117018462 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117018463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117018464 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426117018465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426117018466 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 426117018467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426117018468 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426117018469 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117018470 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 426117018471 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426117018472 minor groove reading motif; other site 426117018473 helix-hairpin-helix signature motif; other site 426117018474 substrate binding pocket [chemical binding]; other site 426117018475 active site 426117018476 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 426117018477 DNA binding and oxoG recognition site [nucleotide binding] 426117018478 Protein of unknown function (DUF721); Region: DUF721; cl02324 426117018479 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426117018480 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 426117018481 catalytic residues [active] 426117018482 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 426117018483 Walker A/P-loop; other site 426117018484 ATP binding site [chemical binding]; other site 426117018485 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 426117018486 ABC transporter signature motif; other site 426117018487 Walker B; other site 426117018488 D-loop; other site 426117018489 H-loop/switch region; other site 426117018490 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 426117018491 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 426117018492 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 426117018493 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 426117018494 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 426117018495 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 426117018496 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426117018497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426117018498 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426117018499 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426117018500 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 426117018501 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 426117018502 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 426117018503 putative MPT binding site; other site 426117018504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426117018505 active site 426117018506 short chain dehydrogenase; Provisional; Region: PRK07109 426117018507 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426117018508 putative NAD(P) binding site [chemical binding]; other site 426117018509 active site 426117018510 Cytochrome c; Region: Cytochrom_C; cl11414 426117018511 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 426117018512 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 426117018513 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 426117018514 Cytochrome c [Energy production and conversion]; Region: COG3258 426117018515 Cytochrome c [Energy production and conversion]; Region: COG3258 426117018516 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 426117018517 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 426117018518 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 426117018519 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 426117018520 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 426117018521 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 426117018522 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 426117018523 agmatinase; Region: agmatinase; TIGR01230 426117018524 oligomer interface [polypeptide binding]; other site 426117018525 putative active site [active] 426117018526 Mn binding site [ion binding]; other site