-- dump date   	20140619_144205
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
440085000001	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
440085000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
440085000003	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
440085000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085000005	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
440085000006	DnaA box-binding interface [nucleotide binding]; other site
440085000007	DNA polymerase III subunit beta; Validated; Region: PRK05643
440085000008	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
440085000009	putative DNA binding surface [nucleotide binding]; other site
440085000010	dimer interface [polypeptide binding]; other site
440085000011	beta-clamp/clamp loader binding surface; other site
440085000012	beta-clamp/translesion DNA polymerase binding surface; other site
440085000013	recombination protein F; Reviewed; Region: recF; PRK00064
440085000014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000015	Walker A/P-loop; other site
440085000016	ATP binding site [chemical binding]; other site
440085000017	Q-loop/lid; other site
440085000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000019	ABC transporter signature motif; other site
440085000020	Walker B; other site
440085000021	D-loop; other site
440085000022	H-loop/switch region; other site
440085000023	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
440085000024	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
440085000025	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
440085000026	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085000027	ATP binding site [chemical binding]; other site
440085000028	putative Mg++ binding site [ion binding]; other site
440085000029	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085000030	nucleotide binding region [chemical binding]; other site
440085000031	ATP-binding site [chemical binding]; other site
440085000032	RQC domain; Region: RQC; pfam09382
440085000033	HRDC domain; Region: HRDC; pfam00570
440085000034	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
440085000035	AAA domain; Region: AAA_30; pfam13604
440085000036	Family description; Region: UvrD_C_2; pfam13538
440085000037	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
440085000038	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
440085000039	dimerization interface [polypeptide binding]; other site
440085000040	ATP binding site [chemical binding]; other site
440085000041	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
440085000042	dimerization interface [polypeptide binding]; other site
440085000043	ATP binding site [chemical binding]; other site
440085000044	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
440085000045	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
440085000046	putative GSH binding site [chemical binding]; other site
440085000047	catalytic residues [active]
440085000048	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
440085000049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085000050	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
440085000051	PAS fold; Region: PAS_3; pfam08447
440085000052	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
440085000053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000054	dimer interface [polypeptide binding]; other site
440085000055	phosphorylation site [posttranslational modification]
440085000056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000057	ATP binding site [chemical binding]; other site
440085000058	Mg2+ binding site [ion binding]; other site
440085000059	G-X-G motif; other site
440085000060	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085000061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000062	active site
440085000063	phosphorylation site [posttranslational modification]
440085000064	intermolecular recognition site; other site
440085000065	dimerization interface [polypeptide binding]; other site
440085000066	circadian clock protein KaiC; Reviewed; Region: PRK09302
440085000067	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085000068	Walker A motif; other site
440085000069	ATP binding site [chemical binding]; other site
440085000070	Walker B motif; other site
440085000071	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085000072	ATP binding site [chemical binding]; other site
440085000073	Walker A motif; other site
440085000074	Walker B motif; other site
440085000075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
440085000076	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
440085000077	short chain dehydrogenase; Provisional; Region: PRK06181
440085000078	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
440085000079	putative NAD(P) binding site [chemical binding]; other site
440085000080	active site
440085000081	Transcriptional regulators [Transcription]; Region: GntR; COG1802
440085000082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085000083	DNA-binding site [nucleotide binding]; DNA binding site
440085000084	FCD domain; Region: FCD; pfam07729
440085000085	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
440085000086	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
440085000087	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
440085000088	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
440085000089	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
440085000090	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
440085000091	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
440085000092	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
440085000093	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
440085000094	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
440085000095	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
440085000096	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
440085000097	Cu(I) binding site [ion binding]; other site
440085000098	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
440085000099	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
440085000100	putative sugar binding sites [chemical binding]; other site
440085000101	Q-X-W motif; other site
440085000102	Galactose oxidase, central domain; Region: Kelch_3; cl02701
440085000103	Galactose oxidase, central domain; Region: Kelch_3; cl02701
440085000104	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
440085000105	transposase; Provisional; Region: PRK06526
440085000106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085000107	Walker A motif; other site
440085000108	ATP binding site [chemical binding]; other site
440085000109	Walker B motif; other site
440085000110	arginine finger; other site
440085000111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
440085000112	Integrase core domain; Region: rve; pfam00665
440085000113	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
440085000114	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
440085000115	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
440085000116	putative active site [active]
440085000117	putative active site [active]
440085000118	catalytic site [active]
440085000119	catalytic site [active]
440085000120	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
440085000121	putative active site [active]
440085000122	catalytic site [active]
440085000123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000124	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085000125	putative active site [active]
440085000126	heme pocket [chemical binding]; other site
440085000127	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
440085000128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000129	putative active site [active]
440085000130	heme pocket [chemical binding]; other site
440085000131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000132	dimer interface [polypeptide binding]; other site
440085000133	phosphorylation site [posttranslational modification]
440085000134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000135	ATP binding site [chemical binding]; other site
440085000136	Mg2+ binding site [ion binding]; other site
440085000137	G-X-G motif; other site
440085000138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085000139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000140	active site
440085000141	phosphorylation site [posttranslational modification]
440085000142	intermolecular recognition site; other site
440085000143	dimerization interface [polypeptide binding]; other site
440085000144	Response regulator receiver domain; Region: Response_reg; pfam00072
440085000145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000146	active site
440085000147	phosphorylation site [posttranslational modification]
440085000148	intermolecular recognition site; other site
440085000149	dimerization interface [polypeptide binding]; other site
440085000150	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
440085000151	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
440085000152	oligomer interface [polypeptide binding]; other site
440085000153	active site
440085000154	metal binding site [ion binding]; metal-binding site
440085000155	Transposase, Mutator family; Region: Transposase_mut; pfam00872
440085000156	MULE transposase domain; Region: MULE; pfam10551
440085000157	response regulator; Provisional; Region: PRK13435
440085000158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000159	active site
440085000160	phosphorylation site [posttranslational modification]
440085000161	intermolecular recognition site; other site
440085000162	dimerization interface [polypeptide binding]; other site
440085000163	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085000164	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085000165	ligand binding site [chemical binding]; other site
440085000166	flexible hinge region; other site
440085000167	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085000168	putative switch regulator; other site
440085000169	non-specific DNA interactions [nucleotide binding]; other site
440085000170	DNA binding site [nucleotide binding]
440085000171	sequence specific DNA binding site [nucleotide binding]; other site
440085000172	putative cAMP binding site [chemical binding]; other site
440085000173	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085000174	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085000175	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085000176	GAF domain; Region: GAF; pfam01590
440085000177	PAS fold; Region: PAS_4; pfam08448
440085000178	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000179	putative active site [active]
440085000180	heme pocket [chemical binding]; other site
440085000181	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000182	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085000183	putative active site [active]
440085000184	heme pocket [chemical binding]; other site
440085000185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000186	dimer interface [polypeptide binding]; other site
440085000187	phosphorylation site [posttranslational modification]
440085000188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000189	ATP binding site [chemical binding]; other site
440085000190	Mg2+ binding site [ion binding]; other site
440085000191	G-X-G motif; other site
440085000192	Response regulator receiver domain; Region: Response_reg; pfam00072
440085000193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000194	active site
440085000195	phosphorylation site [posttranslational modification]
440085000196	intermolecular recognition site; other site
440085000197	dimerization interface [polypeptide binding]; other site
440085000198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085000199	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
440085000200	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
440085000201	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
440085000202	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085000203	active site
440085000204	catalytic residues [active]
440085000205	DNA binding site [nucleotide binding]
440085000206	Int/Topo IB signature motif; other site
440085000207	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
440085000208	Competence protein CoiA-like family; Region: CoiA; cl11541
440085000209	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
440085000210	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
440085000211	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085000212	Mrr N-terminal domain; Region: Mrr_N; pfam14338
440085000213	Restriction endonuclease; Region: Mrr_cat; pfam04471
440085000214	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
440085000215	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085000216	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085000217	active site
440085000218	catalytic residues [active]
440085000219	DNA binding site [nucleotide binding]
440085000220	Int/Topo IB signature motif; other site
440085000221	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085000222	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
440085000223	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
440085000224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000225	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085000226	active site
440085000227	phosphorylation site [posttranslational modification]
440085000228	intermolecular recognition site; other site
440085000229	dimerization interface [polypeptide binding]; other site
440085000230	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
440085000231	Homeodomain-like domain; Region: HTH_32; pfam13565
440085000232	DDE superfamily endonuclease; Region: DDE_3; pfam13358
440085000233	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
440085000234	Phasin protein; Region: Phasin_2; cl11491
440085000235	hypothetical protein; Provisional; Region: PRK13560
440085000236	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085000237	Ligand Binding Site [chemical binding]; other site
440085000238	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
440085000239	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085000240	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
440085000241	putative heme binding site [chemical binding]; other site
440085000242	putative substrate binding site [chemical binding]; other site
440085000243	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
440085000244	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
440085000245	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085000246	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
440085000247	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
440085000248	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085000249	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085000250	active site
440085000251	catalytic residues [active]
440085000252	DNA binding site [nucleotide binding]
440085000253	Int/Topo IB signature motif; other site
440085000254	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
440085000255	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
440085000256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085000257	catalytic residue [active]
440085000258	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
440085000259	active site
440085000260	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
440085000261	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
440085000262	IHF dimer interface [polypeptide binding]; other site
440085000263	IHF - DNA interface [nucleotide binding]; other site
440085000264	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
440085000265	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
440085000266	tandem repeat interface [polypeptide binding]; other site
440085000267	oligomer interface [polypeptide binding]; other site
440085000268	active site residues [active]
440085000269	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
440085000270	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
440085000271	RNA binding site [nucleotide binding]; other site
440085000272	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
440085000273	RNA binding site [nucleotide binding]; other site
440085000274	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
440085000275	RNA binding site [nucleotide binding]; other site
440085000276	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
440085000277	RNA binding site [nucleotide binding]; other site
440085000278	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
440085000279	RNA binding site [nucleotide binding]; other site
440085000280	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
440085000281	RNA binding site [nucleotide binding]; other site
440085000282	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
440085000283	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
440085000284	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
440085000285	Pirin-related protein [General function prediction only]; Region: COG1741
440085000286	Pirin; Region: Pirin; pfam02678
440085000287	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
440085000288	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
440085000289	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
440085000290	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
440085000291	TrkA-N domain; Region: TrkA_N; pfam02254
440085000292	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
440085000293	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
440085000294	minor groove reading motif; other site
440085000295	helix-hairpin-helix signature motif; other site
440085000296	substrate binding pocket [chemical binding]; other site
440085000297	active site
440085000298	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085000299	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085000300	dimer interface [polypeptide binding]; other site
440085000301	putative CheW interface [polypeptide binding]; other site
440085000302	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
440085000303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000304	Walker A/P-loop; other site
440085000305	ATP binding site [chemical binding]; other site
440085000306	Q-loop/lid; other site
440085000307	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085000308	ABC transporter signature motif; other site
440085000309	Walker B; other site
440085000310	D-loop; other site
440085000311	ABC transporter; Region: ABC_tran_2; pfam12848
440085000312	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085000313	Protein of unknown function (DUF419); Region: DUF419; pfam04237
440085000314	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
440085000315	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085000316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085000317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085000318	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
440085000319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085000320	putative ADP-binding pocket [chemical binding]; other site
440085000321	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
440085000322	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
440085000323	putative ADP-binding pocket [chemical binding]; other site
440085000324	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
440085000325	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085000326	active site
440085000327	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
440085000328	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
440085000329	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085000330	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085000331	active site
440085000332	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085000333	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
440085000334	putative ADP-binding pocket [chemical binding]; other site
440085000335	Methyltransferase domain; Region: Methyltransf_24; pfam13578
440085000336	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
440085000337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000338	active site
440085000339	phosphorylation site [posttranslational modification]
440085000340	intermolecular recognition site; other site
440085000341	dimerization interface [polypeptide binding]; other site
440085000342	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085000343	Zn2+ binding site [ion binding]; other site
440085000344	Mg2+ binding site [ion binding]; other site
440085000345	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
440085000346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000347	Walker A/P-loop; other site
440085000348	ATP binding site [chemical binding]; other site
440085000349	Q-loop/lid; other site
440085000350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000351	ABC transporter signature motif; other site
440085000352	Walker B; other site
440085000353	D-loop; other site
440085000354	H-loop/switch region; other site
440085000355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000356	Walker A/P-loop; other site
440085000357	ATP binding site [chemical binding]; other site
440085000358	Q-loop/lid; other site
440085000359	ABC transporter signature motif; other site
440085000360	Walker B; other site
440085000361	D-loop; other site
440085000362	H-loop/switch region; other site
440085000363	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085000364	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
440085000365	conserved cys residue [active]
440085000366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085000367	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
440085000368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085000369	NAD(P) binding site [chemical binding]; other site
440085000370	active site
440085000371	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
440085000372	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085000373	catalytic loop [active]
440085000374	iron binding site [ion binding]; other site
440085000375	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085000376	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085000377	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085000378	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085000379	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085000380	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085000381	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
440085000382	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
440085000383	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
440085000384	ligand binding site [chemical binding]; other site
440085000385	NAD binding site [chemical binding]; other site
440085000386	tetramer interface [polypeptide binding]; other site
440085000387	catalytic site [active]
440085000388	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
440085000389	L-serine binding site [chemical binding]; other site
440085000390	ACT domain interface; other site
440085000391	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
440085000392	FAD binding domain; Region: FAD_binding_4; pfam01565
440085000393	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
440085000394	heme-binding residues [chemical binding]; other site
440085000395	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
440085000396	molybdopterin cofactor binding site; other site
440085000397	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
440085000398	4Fe-4S binding domain; Region: Fer4_2; pfam12797
440085000399	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
440085000400	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
440085000401	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
440085000402	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
440085000403	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
440085000404	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
440085000405	Cytochrome c; Region: Cytochrom_C; pfam00034
440085000406	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
440085000407	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
440085000408	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
440085000409	Subunit I/III interface [polypeptide binding]; other site
440085000410	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
440085000411	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
440085000412	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085000413	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085000414	DNA binding residues [nucleotide binding]
440085000415	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
440085000416	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
440085000417	putative heme binding pocket [chemical binding]; other site
440085000418	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
440085000419	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
440085000420	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
440085000421	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085000422	Soluble P-type ATPase [General function prediction only]; Region: COG4087
440085000423	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
440085000424	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
440085000425	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
440085000426	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
440085000427	Ligand Binding Site [chemical binding]; other site
440085000428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000429	dimer interface [polypeptide binding]; other site
440085000430	phosphorylation site [posttranslational modification]
440085000431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000432	ATP binding site [chemical binding]; other site
440085000433	Mg2+ binding site [ion binding]; other site
440085000434	G-X-G motif; other site
440085000435	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085000436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000437	active site
440085000438	phosphorylation site [posttranslational modification]
440085000439	intermolecular recognition site; other site
440085000440	dimerization interface [polypeptide binding]; other site
440085000441	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085000442	DNA binding site [nucleotide binding]
440085000443	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
440085000444	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
440085000445	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
440085000446	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085000447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085000448	S-adenosylmethionine binding site [chemical binding]; other site
440085000449	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
440085000450	catalytic core [active]
440085000451	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
440085000452	catalytic core [active]
440085000453	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
440085000454	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
440085000455	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
440085000456	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085000457	NAD binding site [chemical binding]; other site
440085000458	putative substrate binding site 2 [chemical binding]; other site
440085000459	putative substrate binding site 1 [chemical binding]; other site
440085000460	active site
440085000461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
440085000462	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
440085000463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
440085000464	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
440085000465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
440085000466	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085000467	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
440085000468	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085000469	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
440085000470	B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295
440085000471	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
440085000472	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085000473	FeS/SAM binding site; other site
440085000474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085000475	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085000476	NAD(P) binding site [chemical binding]; other site
440085000477	active site
440085000478	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085000479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085000480	NAD(P) binding site [chemical binding]; other site
440085000481	active site
440085000482	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
440085000483	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
440085000484	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
440085000485	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
440085000486	catalytic residues [active]
440085000487	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
440085000488	Arginase family; Region: Arginase; cd09989
440085000489	active site
440085000490	Mn binding site [ion binding]; other site
440085000491	oligomer interface [polypeptide binding]; other site
440085000492	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
440085000493	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
440085000494	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085000495	catalytic residue [active]
440085000496	Secretin and TonB N terminus short domain; Region: STN; smart00965
440085000497	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
440085000498	FecR protein; Region: FecR; pfam04773
440085000499	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
440085000500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085000501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085000502	DNA binding residues [nucleotide binding]
440085000503	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085000504	Domain of unknown function DUF20; Region: UPF0118; pfam01594
440085000505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
440085000506	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085000507	putative active site [active]
440085000508	heme pocket [chemical binding]; other site
440085000509	PAS domain; Region: PAS; smart00091
440085000510	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085000511	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
440085000512	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085000513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085000514	DNA binding residues [nucleotide binding]
440085000515	dimerization interface [polypeptide binding]; other site
440085000516	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
440085000517	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
440085000518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085000519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085000520	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
440085000521	putative effector binding pocket; other site
440085000522	putative dimerization interface [polypeptide binding]; other site
440085000523	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085000524	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085000525	active site
440085000526	catalytic tetrad [active]
440085000527	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085000528	GAF domain; Region: GAF; pfam01590
440085000529	PAS domain; Region: PAS_9; pfam13426
440085000530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085000531	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085000532	metal binding site [ion binding]; metal-binding site
440085000533	active site
440085000534	I-site; other site
440085000535	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085000536	GAF domain; Region: GAF; pfam01590
440085000537	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085000538	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
440085000539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
440085000540	dimerization interface [polypeptide binding]; other site
440085000541	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
440085000542	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
440085000543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085000544	PilZ domain; Region: PilZ; pfam07238
440085000545	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085000546	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085000547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
440085000548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085000549	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
440085000550	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
440085000551	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
440085000552	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085000553	active site
440085000554	DNA binding site [nucleotide binding]
440085000555	Int/Topo IB signature motif; other site
440085000556	integrase; Provisional; Region: PRK09692
440085000557	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
440085000558	active site
440085000559	Int/Topo IB signature motif; other site
440085000560	Helix-turn-helix domain; Region: HTH_17; pfam12728
440085000561	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
440085000562	Active Sites [active]
440085000563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085000564	non-specific DNA binding site [nucleotide binding]; other site
440085000565	salt bridge; other site
440085000566	sequence-specific DNA binding site [nucleotide binding]; other site
440085000567	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
440085000568	active site
440085000569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085000570	non-specific DNA binding site [nucleotide binding]; other site
440085000571	Predicted transcriptional regulator [Transcription]; Region: COG2932
440085000572	salt bridge; other site
440085000573	sequence-specific DNA binding site [nucleotide binding]; other site
440085000574	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
440085000575	Catalytic site [active]
440085000576	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
440085000577	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
440085000578	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085000579	Transcription termination factor nusG; Region: NusG; pfam02357
440085000580	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
440085000581	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085000582	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085000583	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000584	PAS domain; Region: PAS_9; pfam13426
440085000585	putative active site [active]
440085000586	heme pocket [chemical binding]; other site
440085000587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000588	dimer interface [polypeptide binding]; other site
440085000589	phosphorylation site [posttranslational modification]
440085000590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000591	ATP binding site [chemical binding]; other site
440085000592	G-X-G motif; other site
440085000593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000594	active site
440085000595	phosphorylation site [posttranslational modification]
440085000596	intermolecular recognition site; other site
440085000597	dimerization interface [polypeptide binding]; other site
440085000598	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
440085000599	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
440085000600	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
440085000601	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
440085000602	tandem repeat interface [polypeptide binding]; other site
440085000603	oligomer interface [polypeptide binding]; other site
440085000604	active site residues [active]
440085000605	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
440085000606	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
440085000607	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
440085000608	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
440085000609	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
440085000610	Phage-related minor tail protein [Function unknown]; Region: COG5281
440085000611	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085000612	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085000613	catalytic residue [active]
440085000614	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
440085000615	PilZ domain; Region: PilZ; pfam07238
440085000616	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085000617	TIGR02594 family protein; Region: TIGR02594
440085000618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085000619	metal binding site [ion binding]; metal-binding site
440085000620	active site
440085000621	I-site; other site
440085000622	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085000623	hypothetical protein; Provisional; Region: PRK01184
440085000624	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
440085000625	active site
440085000626	Zn binding site [ion binding]; other site
440085000627	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
440085000628	Catalytic site [active]
440085000629	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
440085000630	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
440085000631	active site
440085000632	DNA binding site [nucleotide binding]
440085000633	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
440085000634	Staphylococcal nuclease homologues; Region: SNc; smart00318
440085000635	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
440085000636	Catalytic site; other site
440085000637	recombination factor protein RarA; Reviewed; Region: PRK13342
440085000638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085000639	Walker A motif; other site
440085000640	ATP binding site [chemical binding]; other site
440085000641	Walker B motif; other site
440085000642	arginine finger; other site
440085000643	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
440085000644	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
440085000645	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
440085000646	active site
440085000647	Zn binding site [ion binding]; other site
440085000648	putative chaperone; Provisional; Region: PRK11678
440085000649	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
440085000650	nucleotide binding site [chemical binding]; other site
440085000651	putative NEF/HSP70 interaction site [polypeptide binding]; other site
440085000652	SBD interface [polypeptide binding]; other site
440085000653	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
440085000654	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085000655	RNA binding surface [nucleotide binding]; other site
440085000656	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
440085000657	active site
440085000658	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
440085000659	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
440085000660	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085000661	motif II; other site
440085000662	ATP12 chaperone protein; Region: ATP12; cl02228
440085000663	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
440085000664	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
440085000665	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
440085000666	tellurium resistance terB-like protein; Region: terB_like; cd07177
440085000667	metal binding site [ion binding]; metal-binding site
440085000668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085000669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085000670	ketol-acid reductoisomerase; Provisional; Region: PRK05479
440085000671	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
440085000672	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
440085000673	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
440085000674	Methyltransferase domain; Region: Methyltransf_24; pfam13578
440085000675	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
440085000676	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
440085000677	putative NAD(P) binding site [chemical binding]; other site
440085000678	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
440085000679	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
440085000680	tetramer interface [polypeptide binding]; other site
440085000681	heme binding pocket [chemical binding]; other site
440085000682	NADPH binding site [chemical binding]; other site
440085000683	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681
440085000684	putative active site [active]
440085000685	putative substrate binding site [chemical binding]; other site
440085000686	putative coenzyme B12 binding site [chemical binding]; other site
440085000687	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
440085000688	B12 binding site [chemical binding]; other site
440085000689	cobalt ligand [ion binding]; other site
440085000690	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
440085000691	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
440085000692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085000693	NAD(P) binding site [chemical binding]; other site
440085000694	active site
440085000695	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085000696	dimerization interface [polypeptide binding]; other site
440085000697	putative DNA binding site [nucleotide binding]; other site
440085000698	putative Zn2+ binding site [ion binding]; other site
440085000699	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
440085000700	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
440085000701	active site
440085000702	HIGH motif; other site
440085000703	dimer interface [polypeptide binding]; other site
440085000704	KMSKS motif; other site
440085000705	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
440085000706	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
440085000707	substrate binding site [chemical binding]; other site
440085000708	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
440085000709	putative substrate binding pocket [chemical binding]; other site
440085000710	AC domain interface; other site
440085000711	catalytic triad [active]
440085000712	AB domain interface; other site
440085000713	membrane ATPase/protein kinase; Provisional; Region: PRK09435
440085000714	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
440085000715	Walker A; other site
440085000716	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
440085000717	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
440085000718	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085000719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085000720	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085000721	exonuclease subunit SbcD; Provisional; Region: PRK10966
440085000722	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
440085000723	active site
440085000724	metal binding site [ion binding]; metal-binding site
440085000725	DNA binding site [nucleotide binding]
440085000726	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
440085000727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000728	Walker A/P-loop; other site
440085000729	ATP binding site [chemical binding]; other site
440085000730	Q-loop/lid; other site
440085000731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085000732	ABC transporter signature motif; other site
440085000733	Walker B; other site
440085000734	D-loop; other site
440085000735	H-loop/switch region; other site
440085000736	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
440085000737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085000738	putative substrate translocation pore; other site
440085000739	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
440085000740	Methyltransferase domain; Region: Methyltransf_11; pfam08241
440085000741	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
440085000742	Domain of unknown function (DUF427); Region: DUF427; pfam04248
440085000743	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
440085000744	active site
440085000745	8-oxo-dGMP binding site [chemical binding]; other site
440085000746	nudix motif; other site
440085000747	metal binding site [ion binding]; metal-binding site
440085000748	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
440085000749	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
440085000750	heterotetramer interface [polypeptide binding]; other site
440085000751	active site pocket [active]
440085000752	cleavage site
440085000753	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
440085000754	catalytic residues [active]
440085000755	dimer interface [polypeptide binding]; other site
440085000756	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
440085000757	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
440085000758	Proline dehydrogenase; Region: Pro_dh; pfam01619
440085000759	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
440085000760	Glutamate binding site [chemical binding]; other site
440085000761	NAD binding site [chemical binding]; other site
440085000762	catalytic residues [active]
440085000763	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
440085000764	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
440085000765	Part of AAA domain; Region: AAA_19; pfam13245
440085000766	Family description; Region: UvrD_C_2; pfam13538
440085000767	PhoH-like protein; Region: PhoH; pfam02562
440085000768	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
440085000769	amphipathic channel; other site
440085000770	Asn-Pro-Ala signature motifs; other site
440085000771	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
440085000772	active site
440085000773	catalytic site [active]
440085000774	substrate binding site [chemical binding]; other site
440085000775	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
440085000776	Cupin; Region: Cupin_1; smart00835
440085000777	Cupin; Region: Cupin_1; smart00835
440085000778	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
440085000779	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
440085000780	metal binding triad; other site
440085000781	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
440085000782	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
440085000783	metal binding triad; other site
440085000784	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
440085000785	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
440085000786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085000787	dimerization interface [polypeptide binding]; other site
440085000788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085000789	dimer interface [polypeptide binding]; other site
440085000790	phosphorylation site [posttranslational modification]
440085000791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085000792	ATP binding site [chemical binding]; other site
440085000793	Mg2+ binding site [ion binding]; other site
440085000794	G-X-G motif; other site
440085000795	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085000796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000797	active site
440085000798	phosphorylation site [posttranslational modification]
440085000799	intermolecular recognition site; other site
440085000800	dimerization interface [polypeptide binding]; other site
440085000801	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085000802	DNA binding site [nucleotide binding]
440085000803	OsmC-like protein; Region: OsmC; pfam02566
440085000804	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085000805	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085000806	Walker A/P-loop; other site
440085000807	ATP binding site [chemical binding]; other site
440085000808	Q-loop/lid; other site
440085000809	ABC transporter signature motif; other site
440085000810	Walker B; other site
440085000811	D-loop; other site
440085000812	H-loop/switch region; other site
440085000813	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
440085000814	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085000815	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085000816	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085000817	substrate binding pocket [chemical binding]; other site
440085000818	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
440085000819	membrane-bound complex binding site; other site
440085000820	PII uridylyl-transferase; Provisional; Region: PRK05092
440085000821	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
440085000822	metal binding triad; other site
440085000823	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
440085000824	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085000825	Zn2+ binding site [ion binding]; other site
440085000826	Mg2+ binding site [ion binding]; other site
440085000827	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
440085000828	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
440085000829	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
440085000830	dimer interface [polypeptide binding]; other site
440085000831	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
440085000832	prephenate dehydratase; Provisional; Region: PRK11899
440085000833	Prephenate dehydratase; Region: PDT; pfam00800
440085000834	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
440085000835	putative L-Phe binding site [chemical binding]; other site
440085000836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085000837	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
440085000838	active site
440085000839	Cytochrome c2 [Energy production and conversion]; Region: COG3474
440085000840	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
440085000841	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
440085000842	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
440085000843	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
440085000844	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
440085000845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085000846	dimer interface [polypeptide binding]; other site
440085000847	conserved gate region; other site
440085000848	putative PBP binding loops; other site
440085000849	ABC-ATPase subunit interface; other site
440085000850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085000851	Coenzyme A binding pocket [chemical binding]; other site
440085000852	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
440085000853	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085000854	acyl-activating enzyme (AAE) consensus motif; other site
440085000855	AMP binding site [chemical binding]; other site
440085000856	active site
440085000857	CoA binding site [chemical binding]; other site
440085000858	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
440085000859	putative metal binding site; other site
440085000860	PAS domain; Region: PAS_9; pfam13426
440085000861	PAS domain S-box; Region: sensory_box; TIGR00229
440085000862	PAS domain S-box; Region: sensory_box; TIGR00229
440085000863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085000864	putative active site [active]
440085000865	heme pocket [chemical binding]; other site
440085000866	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085000867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085000868	DNA binding residues [nucleotide binding]
440085000869	dimerization interface [polypeptide binding]; other site
440085000870	CsbD-like; Region: CsbD; cl17424
440085000871	CsbD-like; Region: CsbD; pfam05532
440085000872	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
440085000873	CsbD-like; Region: CsbD; pfam05532
440085000874	CsbD-like; Region: CsbD; pfam05532
440085000875	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
440085000876	acetylornithine deacetylase; Provisional; Region: PRK07522
440085000877	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
440085000878	metal binding site [ion binding]; metal-binding site
440085000879	putative dimer interface [polypeptide binding]; other site
440085000880	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
440085000881	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
440085000882	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
440085000883	trimer interface [polypeptide binding]; other site
440085000884	active site
440085000885	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
440085000886	trimer interface [polypeptide binding]; other site
440085000887	active site
440085000888	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
440085000889	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
440085000890	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
440085000891	putative MPT binding site; other site
440085000892	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
440085000893	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
440085000894	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085000895	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085000896	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
440085000897	ABC-2 type transporter; Region: ABC2_membrane; cl17235
440085000898	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
440085000899	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
440085000900	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
440085000901	Walker A/P-loop; other site
440085000902	ATP binding site [chemical binding]; other site
440085000903	Q-loop/lid; other site
440085000904	ABC transporter signature motif; other site
440085000905	Walker B; other site
440085000906	D-loop; other site
440085000907	H-loop/switch region; other site
440085000908	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
440085000909	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
440085000910	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
440085000911	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
440085000912	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
440085000913	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
440085000914	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
440085000915	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
440085000916	[4Fe-4S] binding site [ion binding]; other site
440085000917	molybdopterin cofactor binding site; other site
440085000918	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
440085000919	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
440085000920	molybdopterin cofactor binding site; other site
440085000921	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
440085000922	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
440085000923	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
440085000924	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
440085000925	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
440085000926	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085000927	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
440085000928	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085000929	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085000930	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085000931	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085000932	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
440085000933	ribonuclease PH; Reviewed; Region: rph; PRK00173
440085000934	Ribonuclease PH; Region: RNase_PH_bact; cd11362
440085000935	hexamer interface [polypeptide binding]; other site
440085000936	active site
440085000937	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
440085000938	active site
440085000939	dimerization interface [polypeptide binding]; other site
440085000940	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
440085000941	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085000942	FeS/SAM binding site; other site
440085000943	HemN C-terminal domain; Region: HemN_C; pfam06969
440085000944	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085000945	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
440085000946	putative ligand binding site [chemical binding]; other site
440085000947	Predicted methyltransferases [General function prediction only]; Region: COG0313
440085000948	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
440085000949	putative SAM binding site [chemical binding]; other site
440085000950	putative homodimer interface [polypeptide binding]; other site
440085000951	hypothetical protein; Provisional; Region: PRK14679
440085000952	Response regulator receiver domain; Region: Response_reg; pfam00072
440085000953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000954	active site
440085000955	phosphorylation site [posttranslational modification]
440085000956	intermolecular recognition site; other site
440085000957	dimerization interface [polypeptide binding]; other site
440085000958	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
440085000959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085000960	putative PBP binding loops; other site
440085000961	ABC-ATPase subunit interface; other site
440085000962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085000963	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085000964	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
440085000965	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
440085000966	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
440085000967	active site
440085000968	Zn binding site [ion binding]; other site
440085000969	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
440085000970	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
440085000971	Potassium binding sites [ion binding]; other site
440085000972	Cesium cation binding sites [ion binding]; other site
440085000973	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
440085000974	metal-binding site [ion binding]
440085000975	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085000976	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
440085000977	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
440085000978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085000979	active site
440085000980	phosphorylation site [posttranslational modification]
440085000981	intermolecular recognition site; other site
440085000982	dimerization interface [polypeptide binding]; other site
440085000983	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
440085000984	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
440085000985	active site
440085000986	Riboflavin kinase; Region: Flavokinase; pfam01687
440085000987	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
440085000988	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
440085000989	dimerization interface [polypeptide binding]; other site
440085000990	ligand binding site [chemical binding]; other site
440085000991	NADP binding site [chemical binding]; other site
440085000992	catalytic site [active]
440085000993	Bacterial SH3 domain; Region: SH3_4; pfam06347
440085000994	Bacterial SH3 domain; Region: SH3_4; pfam06347
440085000995	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
440085000996	metal binding site 2 [ion binding]; metal-binding site
440085000997	putative DNA binding helix; other site
440085000998	metal binding site 1 [ion binding]; metal-binding site
440085000999	dimer interface [polypeptide binding]; other site
440085001000	structural Zn2+ binding site [ion binding]; other site
440085001001	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
440085001002	active site 1 [active]
440085001003	dimer interface [polypeptide binding]; other site
440085001004	active site 2 [active]
440085001005	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
440085001006	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
440085001007	dimer interface [polypeptide binding]; other site
440085001008	active site
440085001009	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
440085001010	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
440085001011	NAD binding site [chemical binding]; other site
440085001012	homotetramer interface [polypeptide binding]; other site
440085001013	homodimer interface [polypeptide binding]; other site
440085001014	substrate binding site [chemical binding]; other site
440085001015	active site
440085001016	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
440085001017	Predicted membrane protein [Function unknown]; Region: COG2259
440085001018	hypothetical protein; Provisional; Region: PRK13663
440085001019	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
440085001020	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085001021	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085001022	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
440085001023	PAS domain S-box; Region: sensory_box; TIGR00229
440085001024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001025	putative active site [active]
440085001026	heme pocket [chemical binding]; other site
440085001027	Histidine kinase; Region: HisKA_2; pfam07568
440085001028	PAS fold; Region: PAS_4; pfam08448
440085001029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001030	PAS fold; Region: PAS_3; pfam08447
440085001031	putative active site [active]
440085001032	heme pocket [chemical binding]; other site
440085001033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001034	PAS fold; Region: PAS_3; pfam08447
440085001035	putative active site [active]
440085001036	heme pocket [chemical binding]; other site
440085001037	GAF domain; Region: GAF; pfam01590
440085001038	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085001039	PAS fold; Region: PAS_4; pfam08448
440085001040	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001041	putative active site [active]
440085001042	heme pocket [chemical binding]; other site
440085001043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001044	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085001045	putative active site [active]
440085001046	heme pocket [chemical binding]; other site
440085001047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001048	dimer interface [polypeptide binding]; other site
440085001049	phosphorylation site [posttranslational modification]
440085001050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001051	ATP binding site [chemical binding]; other site
440085001052	Mg2+ binding site [ion binding]; other site
440085001053	G-X-G motif; other site
440085001054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001055	Response regulator receiver domain; Region: Response_reg; pfam00072
440085001056	active site
440085001057	phosphorylation site [posttranslational modification]
440085001058	intermolecular recognition site; other site
440085001059	dimerization interface [polypeptide binding]; other site
440085001060	PAS domain; Region: PAS; smart00091
440085001061	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
440085001062	dimer interface [polypeptide binding]; other site
440085001063	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085001064	active site
440085001065	metal binding site [ion binding]; metal-binding site
440085001066	glutathione binding site [chemical binding]; other site
440085001067	aminopeptidase N; Provisional; Region: pepN; PRK14015
440085001068	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
440085001069	Zn binding site [ion binding]; other site
440085001070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001071	PAS fold; Region: PAS_3; pfam08447
440085001072	putative active site [active]
440085001073	heme pocket [chemical binding]; other site
440085001074	PAS fold; Region: PAS_7; pfam12860
440085001075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085001076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001077	dimer interface [polypeptide binding]; other site
440085001078	phosphorylation site [posttranslational modification]
440085001079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001080	ATP binding site [chemical binding]; other site
440085001081	Mg2+ binding site [ion binding]; other site
440085001082	G-X-G motif; other site
440085001083	Arginase family; Region: Arginase; cd09989
440085001084	active site
440085001085	Mn binding site [ion binding]; other site
440085001086	oligomer interface [polypeptide binding]; other site
440085001087	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
440085001088	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
440085001089	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
440085001090	PilZ domain; Region: PilZ; pfam07238
440085001091	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
440085001092	ATP-NAD kinase; Region: NAD_kinase; pfam01513
440085001093	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
440085001094	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
440085001095	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
440085001096	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
440085001097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085001098	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
440085001099	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
440085001100	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
440085001101	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085001102	catalytic residue [active]
440085001103	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
440085001104	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
440085001105	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
440085001106	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
440085001107	homotetramer interface [polypeptide binding]; other site
440085001108	NAD(P) binding site [chemical binding]; other site
440085001109	homodimer interface [polypeptide binding]; other site
440085001110	active site
440085001111	acyl carrier protein; Provisional; Region: acpP; PRK00982
440085001112	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
440085001113	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
440085001114	dimer interface [polypeptide binding]; other site
440085001115	active site
440085001116	YceG-like family; Region: YceG; pfam02618
440085001117	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
440085001118	dimerization interface [polypeptide binding]; other site
440085001119	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
440085001120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085001121	motif II; other site
440085001122	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
440085001123	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
440085001124	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
440085001125	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
440085001126	Acetokinase family; Region: Acetate_kinase; cl17229
440085001127	propionate/acetate kinase; Provisional; Region: PRK12379
440085001128	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085001129	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
440085001130	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085001131	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
440085001132	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
440085001133	Walker A/P-loop; other site
440085001134	ATP binding site [chemical binding]; other site
440085001135	Q-loop/lid; other site
440085001136	ABC transporter signature motif; other site
440085001137	Walker B; other site
440085001138	D-loop; other site
440085001139	H-loop/switch region; other site
440085001140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085001141	Walker A/P-loop; other site
440085001142	ATP binding site [chemical binding]; other site
440085001143	Q-loop/lid; other site
440085001144	ABC transporter signature motif; other site
440085001145	Walker B; other site
440085001146	D-loop; other site
440085001147	H-loop/switch region; other site
440085001148	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
440085001149	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
440085001150	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
440085001151	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
440085001152	ABC-2 type transporter; Region: ABC2_membrane; cl17235
440085001153	putative phosphoketolase; Provisional; Region: PRK05261
440085001154	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
440085001155	TPP-binding site; other site
440085001156	XFP C-terminal domain; Region: XFP_C; pfam09363
440085001157	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
440085001158	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
440085001159	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085001160	active site
440085001161	DNA binding site [nucleotide binding]
440085001162	Int/Topo IB signature motif; other site
440085001163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001164	PAS domain; Region: PAS_9; pfam13426
440085001165	putative active site [active]
440085001166	heme pocket [chemical binding]; other site
440085001167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085001168	HWE histidine kinase; Region: HWE_HK; smart00911
440085001169	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
440085001170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085001171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085001172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001173	dimer interface [polypeptide binding]; other site
440085001174	phosphorylation site [posttranslational modification]
440085001175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001176	ATP binding site [chemical binding]; other site
440085001177	Mg2+ binding site [ion binding]; other site
440085001178	G-X-G motif; other site
440085001179	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085001180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001181	active site
440085001182	phosphorylation site [posttranslational modification]
440085001183	intermolecular recognition site; other site
440085001184	dimerization interface [polypeptide binding]; other site
440085001185	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
440085001186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085001187	ATP binding site [chemical binding]; other site
440085001188	Mg2+ binding site [ion binding]; other site
440085001189	G-X-G motif; other site
440085001190	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
440085001191	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
440085001192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085001193	ATP binding site [chemical binding]; other site
440085001194	Mg2+ binding site [ion binding]; other site
440085001195	G-X-G motif; other site
440085001196	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
440085001197	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
440085001198	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
440085001199	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085001200	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085001201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085001202	Histidine kinase; Region: HisKA_2; pfam07568
440085001203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001204	ATP binding site [chemical binding]; other site
440085001205	Mg2+ binding site [ion binding]; other site
440085001206	G-X-G motif; other site
440085001207	Response regulator receiver domain; Region: Response_reg; pfam00072
440085001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001209	active site
440085001210	phosphorylation site [posttranslational modification]
440085001211	intermolecular recognition site; other site
440085001212	dimerization interface [polypeptide binding]; other site
440085001213	CHASE3 domain; Region: CHASE3; pfam05227
440085001214	PAS fold; Region: PAS_7; pfam12860
440085001215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001216	dimer interface [polypeptide binding]; other site
440085001217	phosphorylation site [posttranslational modification]
440085001218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001219	ATP binding site [chemical binding]; other site
440085001220	Mg2+ binding site [ion binding]; other site
440085001221	G-X-G motif; other site
440085001222	Response regulator receiver domain; Region: Response_reg; pfam00072
440085001223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001224	active site
440085001225	phosphorylation site [posttranslational modification]
440085001226	intermolecular recognition site; other site
440085001227	dimerization interface [polypeptide binding]; other site
440085001228	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085001229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085001230	metal binding site [ion binding]; metal-binding site
440085001231	active site
440085001232	I-site; other site
440085001233	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
440085001234	dimer interface [polypeptide binding]; other site
440085001235	substrate binding site [chemical binding]; other site
440085001236	metal binding sites [ion binding]; metal-binding site
440085001237	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085001238	PAS fold; Region: PAS; pfam00989
440085001239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001240	putative active site [active]
440085001241	heme pocket [chemical binding]; other site
440085001242	Sensors of blue-light using FAD; Region: BLUF; pfam04940
440085001243	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
440085001244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001245	active site
440085001246	phosphorylation site [posttranslational modification]
440085001247	intermolecular recognition site; other site
440085001248	dimerization interface [polypeptide binding]; other site
440085001249	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
440085001250	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085001251	PAS domain S-box; Region: sensory_box; TIGR00229
440085001252	PAS domain; Region: PAS_8; pfam13188
440085001253	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085001254	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085001255	metal binding site [ion binding]; metal-binding site
440085001256	active site
440085001257	I-site; other site
440085001258	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085001259	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085001260	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085001261	NAD binding site [chemical binding]; other site
440085001262	catalytic Zn binding site [ion binding]; other site
440085001263	structural Zn binding site [ion binding]; other site
440085001264	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
440085001265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085001266	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085001267	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
440085001268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001269	active site
440085001270	phosphorylation site [posttranslational modification]
440085001271	intermolecular recognition site; other site
440085001272	dimerization interface [polypeptide binding]; other site
440085001273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085001274	Zn2+ binding site [ion binding]; other site
440085001275	Mg2+ binding site [ion binding]; other site
440085001276	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001277	PAS domain; Region: PAS_9; pfam13426
440085001278	putative active site [active]
440085001279	heme pocket [chemical binding]; other site
440085001280	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085001281	GAF domain; Region: GAF; pfam01590
440085001282	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085001283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001284	putative active site [active]
440085001285	heme pocket [chemical binding]; other site
440085001286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001287	putative active site [active]
440085001288	heme pocket [chemical binding]; other site
440085001289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001290	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085001291	putative active site [active]
440085001292	heme pocket [chemical binding]; other site
440085001293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001294	dimer interface [polypeptide binding]; other site
440085001295	phosphorylation site [posttranslational modification]
440085001296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001297	ATP binding site [chemical binding]; other site
440085001298	Mg2+ binding site [ion binding]; other site
440085001299	G-X-G motif; other site
440085001300	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085001301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001302	active site
440085001303	phosphorylation site [posttranslational modification]
440085001304	intermolecular recognition site; other site
440085001305	dimerization interface [polypeptide binding]; other site
440085001306	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085001307	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085001308	TadE-like protein; Region: TadE; pfam07811
440085001309	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085001310	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
440085001311	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
440085001312	Uncharacterized conserved protein [Function unknown]; Region: COG2135
440085001313	Cupin domain; Region: Cupin_2; pfam07883
440085001314	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
440085001315	dimer interface [polypeptide binding]; other site
440085001316	catalytic triad [active]
440085001317	peroxidatic and resolving cysteines [active]
440085001318	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
440085001319	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
440085001320	4Fe-4S binding domain; Region: Fer4_5; pfam12801
440085001321	4Fe-4S binding domain; Region: Fer4_5; pfam12801
440085001322	MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397
440085001323	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
440085001324	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
440085001325	amicyanin; Region: amicyanin; TIGR02657
440085001326	methylamine dehydrogenase (amicyanin) light chain; Region: TTQ_MADH_Lt; TIGR02659
440085001327	Methylamine utilization (mau) D family; mauD protein is the translation product of the mauD gene found in methylotrophic bacteria, which are able to use methylamine as a sole carbon source and a nitrogen source. mauD is an essential accessory protein for...; Region: mauD; cd02967
440085001328	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
440085001329	catalytic residues [active]
440085001330	Methylamine utilisation protein MauE; Region: MauE; pfam07291
440085001331	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
440085001332	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085001333	N-terminal plug; other site
440085001334	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085001335	ligand-binding site [chemical binding]; other site
440085001336	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
440085001337	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
440085001338	RNA ligase; Region: RNA_lig_T4_1; cl09743
440085001339	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
440085001340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085001341	Walker A/P-loop; other site
440085001342	ATP binding site [chemical binding]; other site
440085001343	Q-loop/lid; other site
440085001344	ABC transporter signature motif; other site
440085001345	Walker B; other site
440085001346	D-loop; other site
440085001347	H-loop/switch region; other site
440085001348	TOBE domain; Region: TOBE_2; pfam08402
440085001349	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
440085001350	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
440085001351	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
440085001352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085001353	ABC-ATPase subunit interface; other site
440085001354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085001355	putative PBP binding loops; other site
440085001356	dimer interface [polypeptide binding]; other site
440085001357	ABC-ATPase subunit interface; other site
440085001358	CysZ-like protein; Reviewed; Region: PRK12768
440085001359	Kelch motif; Region: Kelch_1; pfam01344
440085001360	Kelch motif; Region: Kelch_6; pfam13964
440085001361	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
440085001362	Galactose oxidase, central domain; Region: Kelch_3; cl02701
440085001363	Kelch domain; Region: Kelch; smart00612
440085001364	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
440085001365	Kelch domain; Region: Kelch; smart00612
440085001366	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
440085001367	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
440085001368	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
440085001369	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085001370	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085001371	ligand binding site [chemical binding]; other site
440085001372	flexible hinge region; other site
440085001373	Cupin domain; Region: Cupin_2; cl17218
440085001374	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
440085001375	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
440085001376	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
440085001377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085001378	dimer interface [polypeptide binding]; other site
440085001379	conserved gate region; other site
440085001380	putative PBP binding loops; other site
440085001381	ABC-ATPase subunit interface; other site
440085001382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085001383	dimer interface [polypeptide binding]; other site
440085001384	conserved gate region; other site
440085001385	putative PBP binding loops; other site
440085001386	ABC-ATPase subunit interface; other site
440085001387	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
440085001388	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
440085001389	Walker A/P-loop; other site
440085001390	ATP binding site [chemical binding]; other site
440085001391	Q-loop/lid; other site
440085001392	ABC transporter signature motif; other site
440085001393	Walker B; other site
440085001394	D-loop; other site
440085001395	H-loop/switch region; other site
440085001396	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
440085001397	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
440085001398	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
440085001399	minor groove reading motif; other site
440085001400	helix-hairpin-helix signature motif; other site
440085001401	substrate binding pocket [chemical binding]; other site
440085001402	active site
440085001403	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
440085001404	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
440085001405	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
440085001406	ATP binding site [chemical binding]; other site
440085001407	active site
440085001408	substrate binding site [chemical binding]; other site
440085001409	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085001410	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085001411	Probable Catalytic site; other site
440085001412	metal-binding site
440085001413	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085001414	active site
440085001415	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085001416	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085001417	Probable Catalytic site; other site
440085001418	metal-binding site
440085001419	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
440085001420	Protein of unknown function DUF45; Region: DUF45; pfam01863
440085001421	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
440085001422	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
440085001423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085001424	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001425	dimer interface [polypeptide binding]; other site
440085001426	phosphorylation site [posttranslational modification]
440085001427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001428	ATP binding site [chemical binding]; other site
440085001429	Mg2+ binding site [ion binding]; other site
440085001430	G-X-G motif; other site
440085001431	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
440085001432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001433	active site
440085001434	phosphorylation site [posttranslational modification]
440085001435	intermolecular recognition site; other site
440085001436	dimerization interface [polypeptide binding]; other site
440085001437	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
440085001438	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
440085001439	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
440085001440	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
440085001441	putative active site [active]
440085001442	catalytic triad [active]
440085001443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085001444	active site
440085001445	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
440085001446	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
440085001447	active site
440085001448	dimerization interface [polypeptide binding]; other site
440085001449	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
440085001450	active site
440085001451	pyrophosphate binding site [ion binding]; other site
440085001452	thiamine phosphate binding site [chemical binding]; other site
440085001453	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
440085001454	ThiS interaction site; other site
440085001455	putative active site [active]
440085001456	tetramer interface [polypeptide binding]; other site
440085001457	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
440085001458	thiS-thiF/thiG interaction site; other site
440085001459	hydroxyglutarate oxidase; Provisional; Region: PRK11728
440085001460	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
440085001461	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085001462	cyclase homology domain; Region: CHD; cd07302
440085001463	nucleotidyl binding site; other site
440085001464	metal binding site [ion binding]; metal-binding site
440085001465	dimer interface [polypeptide binding]; other site
440085001466	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
440085001467	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
440085001468	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
440085001469	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
440085001470	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
440085001471	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085001472	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
440085001473	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085001474	DNA binding residues [nucleotide binding]
440085001475	DNA primase, catalytic core; Region: dnaG; TIGR01391
440085001476	CHC2 zinc finger; Region: zf-CHC2; pfam01807
440085001477	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
440085001478	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
440085001479	active site
440085001480	metal binding site [ion binding]; metal-binding site
440085001481	interdomain interaction site; other site
440085001482	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
440085001483	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
440085001484	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085001485	Major royal jelly protein; Region: MRJP; pfam03022
440085001486	Yqey-like protein; Region: YqeY; pfam09424
440085001487	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
440085001488	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
440085001489	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
440085001490	catalytic site [active]
440085001491	subunit interface [polypeptide binding]; other site
440085001492	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
440085001493	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085001494	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
440085001495	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085001496	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
440085001497	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
440085001498	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085001499	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085001500	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
440085001501	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
440085001502	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
440085001503	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
440085001504	Flagellar P-ring protein; Region: FlgI; pfam02119
440085001505	Uncharacterized conserved protein [Function unknown]; Region: COG3334
440085001506	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
440085001507	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
440085001508	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
440085001509	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783
440085001510	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
440085001511	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
440085001512	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
440085001513	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
440085001514	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085001515	ligand binding site [chemical binding]; other site
440085001516	chemotaxis protein; Reviewed; Region: PRK12798
440085001517	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
440085001518	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
440085001519	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085001520	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085001521	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
440085001522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001523	active site
440085001524	dimerization interface [polypeptide binding]; other site
440085001525	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085001526	DNA binding site [nucleotide binding]
440085001527	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
440085001528	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
440085001529	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
440085001530	FliG C-terminal domain; Region: FliG_C; pfam01706
440085001531	flagellar motor switch protein FliN; Region: fliN; TIGR02480
440085001532	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
440085001533	Flagellar motor switch protein FliM; Region: FliM; pfam02154
440085001534	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
440085001535	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
440085001536	flagellar motor protein MotA; Validated; Region: PRK09110
440085001537	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
440085001538	active site
440085001539	HslU subunit interaction site [polypeptide binding]; other site
440085001540	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
440085001541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085001542	Walker A motif; other site
440085001543	ATP binding site [chemical binding]; other site
440085001544	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
440085001545	Walker B motif; other site
440085001546	arginine finger; other site
440085001547	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
440085001548	threonine and homoserine efflux system; Provisional; Region: PRK10532
440085001549	EamA-like transporter family; Region: EamA; pfam00892
440085001550	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
440085001551	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
440085001552	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085001553	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
440085001554	[2Fe-2S] cluster binding site [ion binding]; other site
440085001555	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
440085001556	hydrophobic ligand binding site; other site
440085001557	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
440085001558	signal recognition particle protein; Provisional; Region: PRK10867
440085001559	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
440085001560	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
440085001561	P loop; other site
440085001562	GTP binding site [chemical binding]; other site
440085001563	Signal peptide binding domain; Region: SRP_SPB; pfam02978
440085001564	chorismate mutase; Provisional; Region: PRK09239
440085001565	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
440085001566	RimM N-terminal domain; Region: RimM; pfam01782
440085001567	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
440085001568	PRC-barrel domain; Region: PRC; pfam05239
440085001569	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
440085001570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085001571	S-adenosylmethionine binding site [chemical binding]; other site
440085001572	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
440085001573	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
440085001574	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085001575	catalytic residue [active]
440085001576	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
440085001577	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
440085001578	ligand binding site [chemical binding]; other site
440085001579	NAD binding site [chemical binding]; other site
440085001580	dimerization interface [polypeptide binding]; other site
440085001581	catalytic site [active]
440085001582	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
440085001583	putative L-serine binding site [chemical binding]; other site
440085001584	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
440085001585	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
440085001586	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
440085001587	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
440085001588	multidrug efflux protein; Reviewed; Region: PRK01766
440085001589	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
440085001590	cation binding site [ion binding]; other site
440085001591	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085001592	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
440085001593	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
440085001594	Walker A/P-loop; other site
440085001595	ATP binding site [chemical binding]; other site
440085001596	Q-loop/lid; other site
440085001597	ABC transporter signature motif; other site
440085001598	Walker B; other site
440085001599	D-loop; other site
440085001600	H-loop/switch region; other site
440085001601	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
440085001602	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085001603	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085001604	dimer interface [polypeptide binding]; other site
440085001605	putative CheW interface [polypeptide binding]; other site
440085001606	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
440085001607	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
440085001608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
440085001609	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
440085001610	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
440085001611	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085001612	N-terminal plug; other site
440085001613	ligand-binding site [chemical binding]; other site
440085001614	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
440085001615	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
440085001616	AAA domain; Region: AAA_30; pfam13604
440085001617	Family description; Region: UvrD_C_2; pfam13538
440085001618	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
440085001619	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085001620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085001621	homodimer interface [polypeptide binding]; other site
440085001622	catalytic residue [active]
440085001623	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085001624	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085001625	DNA binding site [nucleotide binding]
440085001626	PilZ domain; Region: PilZ; pfam07238
440085001627	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
440085001628	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
440085001629	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
440085001630	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
440085001631	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
440085001632	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085001633	Walker A motif; other site
440085001634	ATP binding site [chemical binding]; other site
440085001635	Walker B motif; other site
440085001636	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
440085001637	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085001638	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
440085001639	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085001640	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
440085001641	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
440085001642	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
440085001643	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
440085001644	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
440085001645	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
440085001646	Flagellar protein FlaF; Region: FlaF; pfam07309
440085001647	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
440085001648	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
440085001649	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
440085001650	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781
440085001651	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
440085001652	FHIPEP family; Region: FHIPEP; pfam00771
440085001653	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780
440085001654	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
440085001655	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
440085001656	inhibitor site; inhibition site
440085001657	active site
440085001658	dimer interface [polypeptide binding]; other site
440085001659	catalytic residue [active]
440085001660	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
440085001661	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085001662	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085001663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001664	putative active site [active]
440085001665	heme pocket [chemical binding]; other site
440085001666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085001667	dimer interface [polypeptide binding]; other site
440085001668	phosphorylation site [posttranslational modification]
440085001669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085001670	ATP binding site [chemical binding]; other site
440085001671	Mg2+ binding site [ion binding]; other site
440085001672	G-X-G motif; other site
440085001673	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
440085001674	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
440085001675	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
440085001676	Predicted transcriptional regulators [Transcription]; Region: COG1733
440085001677	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
440085001678	Transglycosylase; Region: Transgly; pfam00912
440085001679	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
440085001680	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
440085001681	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085001682	dimer interface [polypeptide binding]; other site
440085001683	putative CheW interface [polypeptide binding]; other site
440085001684	AMP nucleosidase; Provisional; Region: PRK08292
440085001685	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
440085001686	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
440085001687	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
440085001688	homodimer interaction site [polypeptide binding]; other site
440085001689	cofactor binding site; other site
440085001690	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
440085001691	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
440085001692	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
440085001693	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
440085001694	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
440085001695	putative active site [active]
440085001696	Zn binding site [ion binding]; other site
440085001697	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
440085001698	ligand binding site; other site
440085001699	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
440085001700	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
440085001701	ethanolamine permease; Region: 2A0305; TIGR00908
440085001702	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
440085001703	Fatty acid desaturase; Region: FA_desaturase; pfam00487
440085001704	Di-iron ligands [ion binding]; other site
440085001705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085001706	dimerization interface [polypeptide binding]; other site
440085001707	putative DNA binding site [nucleotide binding]; other site
440085001708	putative Zn2+ binding site [ion binding]; other site
440085001709	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
440085001710	catalytic triad [active]
440085001711	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085001712	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085001713	active site
440085001714	catalytic tetrad [active]
440085001715	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
440085001716	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
440085001717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085001718	Predicted membrane protein [Function unknown]; Region: COG1238
440085001719	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
440085001720	Putative ParB-like nuclease; Region: ParBc_2; cl17538
440085001721	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
440085001722	EVE domain; Region: EVE; pfam01878
440085001723	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
440085001724	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
440085001725	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
440085001726	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001727	PAS domain; Region: PAS_9; pfam13426
440085001728	putative active site [active]
440085001729	heme pocket [chemical binding]; other site
440085001730	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085001731	dimer interface [polypeptide binding]; other site
440085001732	putative CheW interface [polypeptide binding]; other site
440085001733	UGMP family protein; Validated; Region: PRK09604
440085001734	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
440085001735	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
440085001736	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
440085001737	active site
440085001738	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
440085001739	HemY protein N-terminus; Region: HemY_N; pfam07219
440085001740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085001741	dimer interface [polypeptide binding]; other site
440085001742	putative CheW interface [polypeptide binding]; other site
440085001743	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
440085001744	DEAD/DEAH box helicase; Region: DEAD; pfam00270
440085001745	ATP binding site [chemical binding]; other site
440085001746	putative Mg++ binding site [ion binding]; other site
440085001747	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085001748	nucleotide binding region [chemical binding]; other site
440085001749	ATP-binding site [chemical binding]; other site
440085001750	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
440085001751	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
440085001752	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
440085001753	putative NAD(P) binding site [chemical binding]; other site
440085001754	active site
440085001755	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
440085001756	MFS_1 like family; Region: MFS_1_like; pfam12832
440085001757	primosome assembly protein PriA; Validated; Region: PRK05580
440085001758	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085001759	ATP binding site [chemical binding]; other site
440085001760	putative Mg++ binding site [ion binding]; other site
440085001761	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
440085001762	short chain dehydrogenase; Provisional; Region: PRK07109
440085001763	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
440085001764	putative NAD(P) binding site [chemical binding]; other site
440085001765	active site
440085001766	Isochorismatase family; Region: Isochorismatase; pfam00857
440085001767	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
440085001768	catalytic triad [active]
440085001769	conserved cis-peptide bond; other site
440085001770	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085001771	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085001772	NAD binding site [chemical binding]; other site
440085001773	catalytic Zn binding site [ion binding]; other site
440085001774	structural Zn binding site [ion binding]; other site
440085001775	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
440085001776	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
440085001777	short chain dehydrogenase; Provisional; Region: PRK06701
440085001778	NAD binding site [chemical binding]; other site
440085001779	metal binding site [ion binding]; metal-binding site
440085001780	active site
440085001781	short chain dehydrogenase; Provisional; Region: PRK06139
440085001782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085001783	NAD(P) binding site [chemical binding]; other site
440085001784	active site
440085001785	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
440085001786	ABC1 family; Region: ABC1; pfam03109
440085001787	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
440085001788	active site
440085001789	ATP binding site [chemical binding]; other site
440085001790	envelope glycoprotein C; Provisional; Region: PHA03269
440085001791	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
440085001792	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
440085001793	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
440085001794	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
440085001795	RNA binding site [nucleotide binding]; other site
440085001796	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
440085001797	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
440085001798	Walker A/P-loop; other site
440085001799	ATP binding site [chemical binding]; other site
440085001800	Q-loop/lid; other site
440085001801	ABC transporter signature motif; other site
440085001802	Walker B; other site
440085001803	D-loop; other site
440085001804	H-loop/switch region; other site
440085001805	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
440085001806	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
440085001807	FHIPEP family; Region: FHIPEP; pfam00771
440085001808	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
440085001809	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
440085001810	dimerization interface [polypeptide binding]; other site
440085001811	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085001812	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085001813	dimer interface [polypeptide binding]; other site
440085001814	putative CheW interface [polypeptide binding]; other site
440085001815	Predicted integral membrane protein [Function unknown]; Region: COG0392
440085001816	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
440085001817	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
440085001818	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
440085001819	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
440085001820	Walker A motif/ATP binding site; other site
440085001821	Walker B motif; other site
440085001822	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085001823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001824	active site
440085001825	phosphorylation site [posttranslational modification]
440085001826	intermolecular recognition site; other site
440085001827	dimerization interface [polypeptide binding]; other site
440085001828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085001829	DNA binding site [nucleotide binding]
440085001830	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
440085001831	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
440085001832	trimer interface [polypeptide binding]; other site
440085001833	active site
440085001834	substrate binding site [chemical binding]; other site
440085001835	CoA binding site [chemical binding]; other site
440085001836	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
440085001837	Malic enzyme, N-terminal domain; Region: malic; pfam00390
440085001838	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
440085001839	putative NAD(P) binding site [chemical binding]; other site
440085001840	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
440085001841	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
440085001842	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085001843	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085001844	Probable Catalytic site; other site
440085001845	metal-binding site
440085001846	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085001847	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
440085001848	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
440085001849	hypothetical protein; Validated; Region: PRK09104
440085001850	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
440085001851	metal binding site [ion binding]; metal-binding site
440085001852	putative dimer interface [polypeptide binding]; other site
440085001853	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
440085001854	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
440085001855	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085001856	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
440085001857	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
440085001858	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085001859	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085001860	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085001861	camphor resistance protein CrcB; Provisional; Region: PRK14198
440085001862	Predicted membrane protein [Function unknown]; Region: COG2510
440085001863	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
440085001864	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
440085001865	MarR family; Region: MarR_2; pfam12802
440085001866	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085001867	active site
440085001868	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085001869	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085001870	Probable Catalytic site; other site
440085001871	metal-binding site
440085001872	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
440085001873	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
440085001874	substrate binding site; other site
440085001875	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
440085001876	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
440085001877	NAD binding site [chemical binding]; other site
440085001878	homotetramer interface [polypeptide binding]; other site
440085001879	homodimer interface [polypeptide binding]; other site
440085001880	substrate binding site [chemical binding]; other site
440085001881	active site
440085001882	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
440085001883	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085001884	Methyltransferase domain; Region: Methyltransf_12; pfam08242
440085001885	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
440085001886	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
440085001887	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085001888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085001889	NAD(P) binding site [chemical binding]; other site
440085001890	active site
440085001891	Response regulator receiver domain; Region: Response_reg; pfam00072
440085001892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085001893	active site
440085001894	phosphorylation site [posttranslational modification]
440085001895	intermolecular recognition site; other site
440085001896	dimerization interface [polypeptide binding]; other site
440085001897	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
440085001898	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
440085001899	inhibitor-cofactor binding pocket; inhibition site
440085001900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085001901	catalytic residue [active]
440085001902	glycine dehydrogenase; Provisional; Region: PRK05367
440085001903	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085001904	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085001905	catalytic residue [active]
440085001906	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
440085001907	tetramer interface [polypeptide binding]; other site
440085001908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085001909	catalytic residue [active]
440085001910	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
440085001911	lipoyl attachment site [posttranslational modification]; other site
440085001912	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
440085001913	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
440085001914	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
440085001915	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085001916	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085001917	catalytic residue [active]
440085001918	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
440085001919	NlpC/P60 family; Region: NLPC_P60; pfam00877
440085001920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085001921	C factor cell-cell signaling protein; Provisional; Region: PRK09009
440085001922	NAD(P) binding site [chemical binding]; other site
440085001923	active site
440085001924	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
440085001925	MgtC family; Region: MgtC; pfam02308
440085001926	MoxR-like ATPases [General function prediction only]; Region: COG0714
440085001927	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
440085001928	Protein of unknown function DUF58; Region: DUF58; pfam01882
440085001929	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
440085001930	metal ion-dependent adhesion site (MIDAS); other site
440085001931	von Willebrand factor type A domain; Region: VWA_2; pfam13519
440085001932	metal ion-dependent adhesion site (MIDAS); other site
440085001933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085001934	TPR motif; other site
440085001935	binding surface
440085001936	TPR repeat; Region: TPR_11; pfam13414
440085001937	Oxygen tolerance; Region: BatD; pfam13584
440085001938	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
440085001939	putative heme binding pocket [chemical binding]; other site
440085001940	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
440085001941	EamA-like transporter family; Region: EamA; pfam00892
440085001942	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
440085001943	putative active site; other site
440085001944	putative triphosphate binding site [ion binding]; other site
440085001945	methionine sulfoxide reductase B; Provisional; Region: PRK00222
440085001946	SelR domain; Region: SelR; pfam01641
440085001947	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
440085001948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001949	PAS domain; Region: PAS_9; pfam13426
440085001950	putative active site [active]
440085001951	heme pocket [chemical binding]; other site
440085001952	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085001953	PAS domain; Region: PAS_9; pfam13426
440085001954	putative active site [active]
440085001955	heme pocket [chemical binding]; other site
440085001956	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085001957	HWE histidine kinase; Region: HWE_HK; pfam07536
440085001958	malonyl-CoA synthase; Validated; Region: PRK07514
440085001959	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
440085001960	acyl-activating enzyme (AAE) consensus motif; other site
440085001961	active site
440085001962	AMP binding site [chemical binding]; other site
440085001963	CoA binding site [chemical binding]; other site
440085001964	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
440085001965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085001966	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
440085001967	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
440085001968	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
440085001969	intracellular protease, PfpI family; Region: PfpI; TIGR01382
440085001970	proposed catalytic triad [active]
440085001971	conserved cys residue [active]
440085001972	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085001973	DNA-binding site [nucleotide binding]; DNA binding site
440085001974	RNA-binding motif; other site
440085001975	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
440085001976	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
440085001977	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
440085001978	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
440085001979	Permease; Region: Permease; pfam02405
440085001980	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
440085001981	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
440085001982	Walker A/P-loop; other site
440085001983	ATP binding site [chemical binding]; other site
440085001984	Q-loop/lid; other site
440085001985	ABC transporter signature motif; other site
440085001986	Walker B; other site
440085001987	D-loop; other site
440085001988	H-loop/switch region; other site
440085001989	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
440085001990	mce related protein; Region: MCE; pfam02470
440085001991	Protein of unknown function (DUF330); Region: DUF330; cl01135
440085001992	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
440085001993	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
440085001994	active site
440085001995	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
440085001996	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
440085001997	UbiA prenyltransferase family; Region: UbiA; pfam01040
440085001998	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
440085001999	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
440085002000	active site
440085002001	homotetramer interface [polypeptide binding]; other site
440085002002	homodimer interface [polypeptide binding]; other site
440085002003	glutamate--cysteine ligase; Region: PLN02611
440085002004	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
440085002005	CPxP  motif; other site
440085002006	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
440085002007	dimer interface [polypeptide binding]; other site
440085002008	ADP-ribose binding site [chemical binding]; other site
440085002009	active site
440085002010	nudix motif; other site
440085002011	metal binding site [ion binding]; metal-binding site
440085002012	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
440085002013	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
440085002014	primary metal binding site; other site
440085002015	catalytic residues [active]
440085002016	Predicted aspartyl protease [General function prediction only]; Region: COG3577
440085002017	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
440085002018	catalytic motif [active]
440085002019	Catalytic residue [active]
440085002020	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
440085002021	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
440085002022	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
440085002023	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
440085002024	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
440085002025	putative dimer interface [polypeptide binding]; other site
440085002026	active site pocket [active]
440085002027	putative cataytic base [active]
440085002028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085002029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085002030	dimer interface [polypeptide binding]; other site
440085002031	phosphorylation site [posttranslational modification]
440085002032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085002033	ATP binding site [chemical binding]; other site
440085002034	Mg2+ binding site [ion binding]; other site
440085002035	G-X-G motif; other site
440085002036	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
440085002037	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085002038	catalytic loop [active]
440085002039	iron binding site [ion binding]; other site
440085002040	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085002041	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085002042	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085002043	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085002044	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085002045	PAS domain S-box; Region: sensory_box; TIGR00229
440085002046	PAS domain; Region: PAS; smart00091
440085002047	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085002048	GAF domain; Region: GAF; pfam01590
440085002049	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085002050	GAF domain; Region: GAF; cl17456
440085002051	PAS domain; Region: PAS_9; pfam13426
440085002052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085002053	putative active site [active]
440085002054	heme pocket [chemical binding]; other site
440085002055	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085002056	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085002057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085002058	PAS fold; Region: PAS_3; pfam08447
440085002059	putative active site [active]
440085002060	heme pocket [chemical binding]; other site
440085002061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085002062	HWE histidine kinase; Region: HWE_HK; smart00911
440085002063	Amidase; Region: Amidase; cl11426
440085002064	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
440085002065	Amidase; Region: Amidase; cl11426
440085002066	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
440085002067	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
440085002068	B1 nucleotide binding pocket [chemical binding]; other site
440085002069	B2 nucleotide binding pocket [chemical binding]; other site
440085002070	CAS motifs; other site
440085002071	active site
440085002072	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
440085002073	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
440085002074	FAD binding domain; Region: FAD_binding_4; pfam01565
440085002075	Cytochrome c; Region: Cytochrom_C; cl11414
440085002076	Transcriptional regulators [Transcription]; Region: MarR; COG1846
440085002077	MarR family; Region: MarR; pfam01047
440085002078	Predicted integral membrane protein [Function unknown]; Region: COG5436
440085002079	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
440085002080	Transglycosylase; Region: Transgly; pfam00912
440085002081	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
440085002082	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
440085002083	hypothetical protein; Provisional; Region: PRK05170
440085002084	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085002085	TadE-like protein; Region: TadE; pfam07811
440085002086	Predicted ATPase [General function prediction only]; Region: COG1485
440085002087	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
440085002088	active site
440085002089	DNA binding site [nucleotide binding]
440085002090	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
440085002091	RNA/DNA hybrid binding site [nucleotide binding]; other site
440085002092	active site
440085002093	glutathione synthetase; Provisional; Region: PRK05246
440085002094	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
440085002095	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
440085002096	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
440085002097	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
440085002098	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
440085002099	amidase catalytic site [active]
440085002100	Zn binding residues [ion binding]; other site
440085002101	substrate binding site [chemical binding]; other site
440085002102	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085002103	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
440085002104	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
440085002105	putative metal binding site [ion binding]; other site
440085002106	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
440085002107	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
440085002108	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
440085002109	FMN binding site [chemical binding]; other site
440085002110	active site
440085002111	catalytic residues [active]
440085002112	substrate binding site [chemical binding]; other site
440085002113	PAS fold; Region: PAS_7; pfam12860
440085002114	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085002115	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085002116	metal binding site [ion binding]; metal-binding site
440085002117	active site
440085002118	I-site; other site
440085002119	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085002120	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
440085002121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085002122	active site
440085002123	phosphorylation site [posttranslational modification]
440085002124	intermolecular recognition site; other site
440085002125	dimerization interface [polypeptide binding]; other site
440085002126	Sensors of blue-light using FAD; Region: BLUF; pfam04940
440085002127	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
440085002128	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085002129	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
440085002130	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085002131	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
440085002132	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085002133	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
440085002134	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
440085002135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085002136	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
440085002137	peptide chain release factor 1; Validated; Region: prfA; PRK00591
440085002138	This domain is found in peptide chain release factors; Region: PCRF; smart00937
440085002139	RF-1 domain; Region: RF-1; pfam00472
440085002140	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
440085002141	GAF domain; Region: GAF; pfam01590
440085002142	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
440085002143	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
440085002144	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
440085002145	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
440085002146	aspartate kinase; Reviewed; Region: PRK06635
440085002147	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
440085002148	putative nucleotide binding site [chemical binding]; other site
440085002149	putative catalytic residues [active]
440085002150	putative Mg ion binding site [ion binding]; other site
440085002151	putative aspartate binding site [chemical binding]; other site
440085002152	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
440085002153	putative allosteric regulatory site; other site
440085002154	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
440085002155	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
440085002156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085002157	S-adenosylmethionine binding site [chemical binding]; other site
440085002158	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
440085002159	substrate binding site [chemical binding]; other site
440085002160	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
440085002161	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
440085002162	NAD(P) binding site [chemical binding]; other site
440085002163	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
440085002164	active site
440085002165	putative DNA-binding cleft [nucleotide binding]; other site
440085002166	dimer interface [polypeptide binding]; other site
440085002167	Uncharacterized conserved protein [Function unknown]; Region: COG2353
440085002168	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
440085002169	RuvA N terminal domain; Region: RuvA_N; pfam01330
440085002170	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
440085002171	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085002172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085002173	active site
440085002174	phosphorylation site [posttranslational modification]
440085002175	intermolecular recognition site; other site
440085002176	dimerization interface [polypeptide binding]; other site
440085002177	response regulator PleD; Reviewed; Region: pleD; PRK09581
440085002178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085002179	active site
440085002180	phosphorylation site [posttranslational modification]
440085002181	intermolecular recognition site; other site
440085002182	dimerization interface [polypeptide binding]; other site
440085002183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085002184	active site
440085002185	phosphorylation site [posttranslational modification]
440085002186	intermolecular recognition site; other site
440085002187	dimerization interface [polypeptide binding]; other site
440085002188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085002189	metal binding site [ion binding]; metal-binding site
440085002190	active site
440085002191	I-site; other site
440085002192	Predicted transcriptional regulator [Transcription]; Region: COG1959
440085002193	Transcriptional regulator; Region: Rrf2; cl17282
440085002194	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
440085002195	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
440085002196	heme-binding site [chemical binding]; other site
440085002197	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
440085002198	FAD binding pocket [chemical binding]; other site
440085002199	FAD binding motif [chemical binding]; other site
440085002200	phosphate binding motif [ion binding]; other site
440085002201	beta-alpha-beta structure motif; other site
440085002202	NAD binding pocket [chemical binding]; other site
440085002203	Heme binding  pocket [chemical binding]; other site
440085002204	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
440085002205	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
440085002206	dimer interface [polypeptide binding]; other site
440085002207	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085002208	catalytic residue [active]
440085002209	META domain; Region: META; pfam03724
440085002210	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
440085002211	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085002212	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085002213	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002215	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
440085002216	putative dimerization interface [polypeptide binding]; other site
440085002217	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
440085002218	metal binding site [ion binding]; metal-binding site
440085002219	active site
440085002220	phosphoribulokinase; Provisional; Region: PRK15453
440085002221	active site
440085002222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085002223	H-loop/switch region; other site
440085002224	hypothetical protein; Validated; Region: PRK00110
440085002225	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085002226	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
440085002227	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
440085002228	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
440085002229	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
440085002230	oxyanion hole [active]
440085002231	OpgC protein; Region: OpgC_C; pfam10129
440085002232	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
440085002233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085002234	motif II; other site
440085002235	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
440085002236	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
440085002237	substrate binding site [chemical binding]; other site
440085002238	hexamer interface [polypeptide binding]; other site
440085002239	metal binding site [ion binding]; metal-binding site
440085002240	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
440085002241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085002242	Coenzyme A binding pocket [chemical binding]; other site
440085002243	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
440085002244	ornithine decarboxylase; Provisional; Region: PRK13578
440085002245	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085002246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085002247	catalytic residue [active]
440085002248	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
440085002249	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
440085002250	MPT binding site; other site
440085002251	trimer interface [polypeptide binding]; other site
440085002252	adenylosuccinate lyase; Provisional; Region: PRK07492
440085002253	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
440085002254	tetramer interface [polypeptide binding]; other site
440085002255	active site
440085002256	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
440085002257	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
440085002258	homodimer interface [polypeptide binding]; other site
440085002259	substrate-cofactor binding pocket; other site
440085002260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085002261	catalytic residue [active]
440085002262	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
440085002263	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
440085002264	GDP-binding site [chemical binding]; other site
440085002265	ACT binding site; other site
440085002266	IMP binding site; other site
440085002267	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
440085002268	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
440085002269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085002270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085002271	DNA binding residues [nucleotide binding]
440085002272	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085002273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085002274	metal binding site [ion binding]; metal-binding site
440085002275	active site
440085002276	I-site; other site
440085002277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085002278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085002279	Coenzyme A binding pocket [chemical binding]; other site
440085002280	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
440085002281	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085002282	RNA binding surface [nucleotide binding]; other site
440085002283	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
440085002284	active site
440085002285	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085002286	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085002287	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085002288	DNA binding site [nucleotide binding]
440085002289	Int/Topo IB signature motif; other site
440085002290	active site
440085002291	catalytic residues [active]
440085002292	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085002293	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085002294	active site
440085002295	catalytic residues [active]
440085002296	DNA binding site [nucleotide binding]
440085002297	Int/Topo IB signature motif; other site
440085002298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
440085002299	sequence-specific DNA binding site [nucleotide binding]; other site
440085002300	salt bridge; other site
440085002301	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085002302	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085002303	non-specific DNA binding site [nucleotide binding]; other site
440085002304	salt bridge; other site
440085002305	sequence-specific DNA binding site [nucleotide binding]; other site
440085002306	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
440085002307	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085002308	N-terminal plug; other site
440085002309	ligand-binding site [chemical binding]; other site
440085002310	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
440085002311	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
440085002312	catalytic residues [active]
440085002313	catalytic nucleophile [active]
440085002314	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085002315	Recombinase; Region: Recombinase; pfam07508
440085002316	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
440085002317	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
440085002318	catalytic residues [active]
440085002319	catalytic nucleophile [active]
440085002320	Recombinase; Region: Recombinase; pfam07508
440085002321	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
440085002322	putative active site [active]
440085002323	putative metal binding site [ion binding]; other site
440085002324	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085002325	non-specific DNA binding site [nucleotide binding]; other site
440085002326	salt bridge; other site
440085002327	sequence-specific DNA binding site [nucleotide binding]; other site
440085002328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085002329	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085002330	Walker A motif; other site
440085002331	ATP binding site [chemical binding]; other site
440085002332	Walker B motif; other site
440085002333	arginine finger; other site
440085002334	Peptidase family M41; Region: Peptidase_M41; pfam01434
440085002335	YCII-related domain; Region: YCII; cl00999
440085002336	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
440085002337	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002338	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085002339	Protein export membrane protein; Region: SecD_SecF; cl14618
440085002340	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085002341	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
440085002342	dimerization interface [polypeptide binding]; other site
440085002343	YHS domain; Region: YHS; pfam04945
440085002344	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
440085002345	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085002346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085002347	motif II; other site
440085002348	Protein of unknown function, DUF; Region: DUF411; cl01142
440085002349	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085002350	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085002351	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
440085002352	putative homodimer interface [polypeptide binding]; other site
440085002353	putative homotetramer interface [polypeptide binding]; other site
440085002354	putative allosteric switch controlling residues; other site
440085002355	putative metal binding site [ion binding]; other site
440085002356	putative homodimer-homodimer interface [polypeptide binding]; other site
440085002357	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
440085002358	metal-binding site [ion binding]
440085002359	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085002360	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085002361	YHS domain; Region: YHS; pfam04945
440085002362	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
440085002363	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
440085002364	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085002365	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085002366	catalytic residue [active]
440085002367	Protein of unknown function, DUF; Region: DUF411; cl01142
440085002368	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085002369	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
440085002370	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002371	YtkA-like; Region: YtkA; pfam13115
440085002372	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
440085002373	RNA polymerase sigma factor; Provisional; Region: PRK12539
440085002374	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085002375	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
440085002376	DNA binding residues [nucleotide binding]
440085002377	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085002378	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
440085002379	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
440085002380	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
440085002381	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
440085002382	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
440085002383	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
440085002384	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
440085002385	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
440085002386	MOFRL family; Region: MOFRL; pfam05161
440085002387	pyruvate kinase; Provisional; Region: PRK06247
440085002388	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
440085002389	domain interfaces; other site
440085002390	active site
440085002391	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
440085002392	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085002393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085002394	dimerization interface [polypeptide binding]; other site
440085002395	putative DNA binding site [nucleotide binding]; other site
440085002396	putative Zn2+ binding site [ion binding]; other site
440085002397	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
440085002398	Low molecular weight phosphatase family; Region: LMWPc; cd00115
440085002399	active site
440085002400	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
440085002401	ArsC family; Region: ArsC; pfam03960
440085002402	catalytic residues [active]
440085002403	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
440085002404	arsenical-resistance protein; Region: acr3; TIGR00832
440085002405	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
440085002406	active site
440085002407	catalytic triad [active]
440085002408	Transposase; Region: HTH_Tnp_1; pfam01527
440085002409	putative transposase OrfB; Reviewed; Region: PHA02517
440085002410	HTH-like domain; Region: HTH_21; pfam13276
440085002411	Integrase core domain; Region: rve; pfam00665
440085002412	Integrase core domain; Region: rve_3; pfam13683
440085002413	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085002414	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085002415	DNA binding residues [nucleotide binding]
440085002416	Fic/DOC family; Region: Fic; pfam02661
440085002417	Fic/DOC family; Region: Fic; cl00960
440085002418	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
440085002419	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085002420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085002421	active site
440085002422	phosphorylation site [posttranslational modification]
440085002423	intermolecular recognition site; other site
440085002424	dimerization interface [polypeptide binding]; other site
440085002425	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085002426	DNA binding site [nucleotide binding]
440085002427	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085002428	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085002429	dimerization interface [polypeptide binding]; other site
440085002430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085002431	ATP binding site [chemical binding]; other site
440085002432	Mg2+ binding site [ion binding]; other site
440085002433	G-X-G motif; other site
440085002434	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
440085002435	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002436	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
440085002437	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
440085002438	Pleiotropic Drug Resistance (PDR) Family protein; Region: 3a01205; TIGR00956
440085002439	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
440085002440	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
440085002441	Abi-like protein; Region: Abi_2; pfam07751
440085002442	putative transposase OrfB; Reviewed; Region: PHA02517
440085002443	HTH-like domain; Region: HTH_21; pfam13276
440085002444	Integrase core domain; Region: rve; pfam00665
440085002445	Integrase core domain; Region: rve_3; pfam13683
440085002446	Transposase; Region: HTH_Tnp_1; pfam01527
440085002447	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085002448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085002449	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085002450	putative transposase OrfB; Reviewed; Region: PHA02517
440085002451	HTH-like domain; Region: HTH_21; pfam13276
440085002452	Integrase core domain; Region: rve; pfam00665
440085002453	Integrase core domain; Region: rve_2; pfam13333
440085002454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
440085002455	Homeodomain-like domain; Region: HTH_32; pfam13565
440085002456	DDE superfamily endonuclease; Region: DDE_3; pfam13358
440085002457	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
440085002458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
440085002459	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
440085002460	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
440085002461	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
440085002462	metal-binding site [ion binding]
440085002463	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085002464	Soluble P-type ATPase [General function prediction only]; Region: COG4087
440085002465	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
440085002466	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
440085002467	DNA binding residues [nucleotide binding]
440085002468	dimer interface [polypeptide binding]; other site
440085002469	putative metal binding site [ion binding]; other site
440085002470	YHS domain; Region: YHS; pfam04945
440085002471	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
440085002472	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085002473	Soluble P-type ATPase [General function prediction only]; Region: COG4087
440085002474	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085002475	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
440085002476	dimerization interface [polypeptide binding]; other site
440085002477	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085002478	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085002479	Protein export membrane protein; Region: SecD_SecF; cl14618
440085002480	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
440085002481	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002482	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
440085002483	metal-binding site [ion binding]
440085002484	LabA_like proteins; Region: LabA_like; cd06167
440085002485	putative metal binding site [ion binding]; other site
440085002486	Protein of unknown function, DUF; Region: DUF411; cl01142
440085002487	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085002488	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
440085002489	DNA-binding interface [nucleotide binding]; DNA binding site
440085002490	putative transposase OrfB; Reviewed; Region: PHA02517
440085002491	HTH-like domain; Region: HTH_21; pfam13276
440085002492	Integrase core domain; Region: rve; pfam00665
440085002493	Integrase core domain; Region: rve_3; pfam13683
440085002494	Cenp-O kinetochore centromere component; Region: CENP-O; pfam09496
440085002495	Transposase, Mutator family; Region: Transposase_mut; pfam00872
440085002496	MULE transposase domain; Region: MULE; pfam10551
440085002497	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
440085002498	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
440085002499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085002500	non-specific DNA binding site [nucleotide binding]; other site
440085002501	salt bridge; other site
440085002502	sequence-specific DNA binding site [nucleotide binding]; other site
440085002503	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
440085002504	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002506	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
440085002507	putative effector binding pocket; other site
440085002508	putative dimerization interface [polypeptide binding]; other site
440085002509	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
440085002510	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
440085002511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085002512	putative substrate translocation pore; other site
440085002513	classical (c) SDRs; Region: SDR_c; cd05233
440085002514	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
440085002515	NAD(P) binding site [chemical binding]; other site
440085002516	active site
440085002517	Uncharacterized conserved protein [Function unknown]; Region: COG4925
440085002518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002520	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
440085002521	putative effector binding pocket; other site
440085002522	putative dimerization interface [polypeptide binding]; other site
440085002523	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
440085002524	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085002525	catalytic loop [active]
440085002526	iron binding site [ion binding]; other site
440085002527	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085002528	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
440085002529	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
440085002530	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085002531	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085002532	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085002533	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
440085002534	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
440085002535	GTPase/Zn-binding domain interface [polypeptide binding]; other site
440085002536	GTP/Mg2+ binding site [chemical binding]; other site
440085002537	G4 box; other site
440085002538	G5 box; other site
440085002539	G1 box; other site
440085002540	Switch I region; other site
440085002541	G2 box; other site
440085002542	G3 box; other site
440085002543	Switch II region; other site
440085002544	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
440085002545	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085002546	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
440085002547	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
440085002548	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
440085002549	active site
440085002550	HIGH motif; other site
440085002551	nucleotide binding site [chemical binding]; other site
440085002552	active site
440085002553	KMSKS motif; other site
440085002554	heat shock protein 90; Provisional; Region: PRK05218
440085002555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085002556	ATP binding site [chemical binding]; other site
440085002557	Mg2+ binding site [ion binding]; other site
440085002558	G-X-G motif; other site
440085002559	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
440085002560	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
440085002561	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
440085002562	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
440085002563	DAK2 domain; Region: Dak2; pfam02734
440085002564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085002565	S-adenosylmethionine binding site [chemical binding]; other site
440085002566	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085002567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085002568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085002569	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
440085002570	active site
440085002571	putative homodimer interface [polypeptide binding]; other site
440085002572	SAM binding site [chemical binding]; other site
440085002573	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
440085002574	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
440085002575	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
440085002576	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085002577	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085002578	metal binding site [ion binding]; metal-binding site
440085002579	active site
440085002580	I-site; other site
440085002581	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
440085002584	dimerization interface [polypeptide binding]; other site
440085002585	Predicted membrane protein [Function unknown]; Region: COG4125
440085002586	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
440085002587	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
440085002588	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
440085002589	active site
440085002590	SAM binding site [chemical binding]; other site
440085002591	homodimer interface [polypeptide binding]; other site
440085002592	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
440085002593	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085002594	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
440085002595	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085002596	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085002597	non-specific DNA binding site [nucleotide binding]; other site
440085002598	salt bridge; other site
440085002599	sequence-specific DNA binding site [nucleotide binding]; other site
440085002600	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
440085002601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085002602	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085002603	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
440085002604	Bacterial sugar transferase; Region: Bac_transf; pfam02397
440085002605	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
440085002606	metal binding site 2 [ion binding]; metal-binding site
440085002607	putative DNA binding helix; other site
440085002608	metal binding site 1 [ion binding]; metal-binding site
440085002609	dimer interface [polypeptide binding]; other site
440085002610	structural Zn2+ binding site [ion binding]; other site
440085002611	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
440085002612	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
440085002613	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
440085002614	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
440085002615	ABC-ATPase subunit  interface; other site
440085002616	dimer interface [polypeptide binding]; other site
440085002617	putative PBP binding regions; other site
440085002618	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
440085002619	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
440085002620	putative active site [active]
440085002621	putative PHP Thumb interface [polypeptide binding]; other site
440085002622	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
440085002623	generic binding surface II; other site
440085002624	generic binding surface I; other site
440085002625	lytic murein transglycosylase; Region: MltB_2; TIGR02283
440085002626	murein hydrolase B; Provisional; Region: PRK10760; cl17906
440085002627	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
440085002628	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
440085002629	putative active site pocket [active]
440085002630	dimerization interface [polypeptide binding]; other site
440085002631	putative catalytic residue [active]
440085002632	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
440085002633	Recombination protein O N terminal; Region: RecO_N; pfam11967
440085002634	Recombination protein O C terminal; Region: RecO_C; pfam02565
440085002635	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
440085002636	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
440085002637	CAP-like domain; other site
440085002638	active site
440085002639	primary dimer interface [polypeptide binding]; other site
440085002640	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
440085002641	rRNA binding site [nucleotide binding]; other site
440085002642	predicted 30S ribosome binding site; other site
440085002643	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
440085002644	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
440085002645	dimerization interface [polypeptide binding]; other site
440085002646	ligand binding site [chemical binding]; other site
440085002647	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
440085002648	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
440085002649	XdhC Rossmann domain; Region: XdhC_C; pfam13478
440085002650	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
440085002651	MPT binding site; other site
440085002652	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
440085002653	Ligand binding site; other site
440085002654	metal-binding site
440085002655	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
440085002656	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
440085002657	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
440085002658	active site
440085002659	cosubstrate binding site; other site
440085002660	substrate binding site [chemical binding]; other site
440085002661	catalytic site [active]
440085002662	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
440085002663	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
440085002664	classical (c) SDRs; Region: SDR_c; cd05233
440085002665	NAD(P) binding site [chemical binding]; other site
440085002666	active site
440085002667	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
440085002668	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
440085002669	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
440085002670	Walker A/P-loop; other site
440085002671	ATP binding site [chemical binding]; other site
440085002672	Q-loop/lid; other site
440085002673	ABC transporter signature motif; other site
440085002674	Walker B; other site
440085002675	D-loop; other site
440085002676	H-loop/switch region; other site
440085002677	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
440085002678	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
440085002679	FtsX-like permease family; Region: FtsX; pfam02687
440085002680	prolyl-tRNA synthetase; Provisional; Region: PRK12325
440085002681	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
440085002682	dimer interface [polypeptide binding]; other site
440085002683	motif 1; other site
440085002684	active site
440085002685	motif 2; other site
440085002686	motif 3; other site
440085002687	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
440085002688	anticodon binding site; other site
440085002689	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
440085002690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085002691	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
440085002692	dimer interface [polypeptide binding]; other site
440085002693	substrate binding site [chemical binding]; other site
440085002694	metal binding site [ion binding]; metal-binding site
440085002695	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
440085002696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085002697	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
440085002698	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
440085002699	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
440085002700	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
440085002701	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
440085002702	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
440085002703	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
440085002704	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
440085002705	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
440085002706	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
440085002707	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
440085002708	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
440085002709	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
440085002710	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
440085002711	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
440085002712	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
440085002713	4Fe-4S binding domain; Region: Fer4; pfam00037
440085002714	4Fe-4S binding domain; Region: Fer4; pfam00037
440085002715	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
440085002716	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
440085002717	NADH dehydrogenase subunit G; Validated; Region: PRK09130
440085002718	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085002719	catalytic loop [active]
440085002720	iron binding site [ion binding]; other site
440085002721	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
440085002722	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
440085002723	molybdopterin cofactor binding site; other site
440085002724	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
440085002725	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
440085002726	SLBB domain; Region: SLBB; pfam10531
440085002727	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
440085002728	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
440085002729	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
440085002730	putative dimer interface [polypeptide binding]; other site
440085002731	[2Fe-2S] cluster binding site [ion binding]; other site
440085002732	Uncharacterized conserved protein [Function unknown]; Region: COG3743
440085002733	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
440085002734	NADH dehydrogenase subunit D; Validated; Region: PRK06075
440085002735	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
440085002736	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
440085002737	NADH dehydrogenase subunit B; Validated; Region: PRK06411
440085002738	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
440085002739	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
440085002740	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
440085002741	pseudoazurin; Region: pseudoazurin; TIGR02375
440085002742	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
440085002743	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
440085002744	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085002745	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
440085002746	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
440085002747	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085002748	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
440085002749	IMP binding site; other site
440085002750	dimer interface [polypeptide binding]; other site
440085002751	partial ornithine binding site; other site
440085002752	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
440085002753	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
440085002754	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085002755	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
440085002756	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
440085002757	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
440085002758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085002759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085002760	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002761	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002762	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085002763	putative effector binding pocket; other site
440085002764	dimerization interface [polypeptide binding]; other site
440085002765	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
440085002766	Dehydroquinase class II; Region: DHquinase_II; pfam01220
440085002767	trimer interface [polypeptide binding]; other site
440085002768	active site
440085002769	dimer interface [polypeptide binding]; other site
440085002770	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
440085002771	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
440085002772	carboxyltransferase (CT) interaction site; other site
440085002773	biotinylation site [posttranslational modification]; other site
440085002774	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
440085002775	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
440085002776	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
440085002777	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
440085002778	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
440085002779	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085002780	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085002781	WHG domain; Region: WHG; pfam13305
440085002782	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
440085002783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
440085002784	NADH dehydrogenase; Validated; Region: PRK08183
440085002785	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
440085002786	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
440085002787	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
440085002788	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
440085002789	active site
440085002790	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
440085002791	TSCPD domain; Region: TSCPD; pfam12637
440085002792	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
440085002793	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
440085002794	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
440085002795	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
440085002796	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085002797	putative active site [active]
440085002798	putative metal binding site [ion binding]; other site
440085002799	Domain of unknown function (DUF892); Region: DUF892; pfam05974
440085002800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
440085002801	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
440085002802	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
440085002803	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
440085002804	active site
440085002805	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
440085002806	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
440085002807	active site
440085002808	ATP binding site [chemical binding]; other site
440085002809	substrate binding site [chemical binding]; other site
440085002810	activation loop (A-loop); other site
440085002811	Cellulose synthase-like protein; Region: PLN02893
440085002812	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
440085002813	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
440085002814	DXD motif; other site
440085002815	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
440085002816	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002817	PRC-barrel domain; Region: PRC; pfam05239
440085002818	Ion channel; Region: Ion_trans_2; pfam07885
440085002819	Predicted membrane protein [Function unknown]; Region: COG2323
440085002820	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
440085002821	homotrimer interaction site [polypeptide binding]; other site
440085002822	putative active site [active]
440085002823	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
440085002824	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
440085002825	active site
440085002826	FMN binding site [chemical binding]; other site
440085002827	substrate binding site [chemical binding]; other site
440085002828	putative catalytic residue [active]
440085002829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002831	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085002832	putative effector binding pocket; other site
440085002833	dimerization interface [polypeptide binding]; other site
440085002834	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
440085002835	primary metal binding site; other site
440085002836	catalytic residues [active]
440085002837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002839	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085002840	dimerization interface [polypeptide binding]; other site
440085002841	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085002842	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085002843	membrane-bound complex binding site; other site
440085002844	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085002845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085002846	dimer interface [polypeptide binding]; other site
440085002847	conserved gate region; other site
440085002848	putative PBP binding loops; other site
440085002849	ABC-ATPase subunit interface; other site
440085002850	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085002851	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085002852	Walker A/P-loop; other site
440085002853	ATP binding site [chemical binding]; other site
440085002854	Q-loop/lid; other site
440085002855	ABC transporter signature motif; other site
440085002856	Walker B; other site
440085002857	D-loop; other site
440085002858	H-loop/switch region; other site
440085002859	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
440085002860	allophanate hydrolase; Provisional; Region: PRK08186
440085002861	Amidase; Region: Amidase; cl11426
440085002862	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
440085002863	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085002864	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
440085002865	NAD(P) binding site [chemical binding]; other site
440085002866	active site
440085002867	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085002868	GAF domain; Region: GAF; pfam01590
440085002869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085002870	putative active site [active]
440085002871	PAS fold; Region: PAS_3; pfam08447
440085002872	heme pocket [chemical binding]; other site
440085002873	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085002874	HWE histidine kinase; Region: HWE_HK; smart00911
440085002875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085002876	NAD(P) binding site [chemical binding]; other site
440085002877	active site
440085002878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085002879	S-adenosylmethionine binding site [chemical binding]; other site
440085002880	Methyltransferase domain; Region: Methyltransf_11; pfam08241
440085002881	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
440085002882	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085002883	cyclase homology domain; Region: CHD; cd07302
440085002884	nucleotidyl binding site; other site
440085002885	metal binding site [ion binding]; metal-binding site
440085002886	dimer interface [polypeptide binding]; other site
440085002887	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085002888	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
440085002889	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
440085002890	SurA N-terminal domain; Region: SurA_N; pfam09312
440085002891	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085002892	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
440085002893	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
440085002894	putative ligand binding site [chemical binding]; other site
440085002895	putative NAD binding site [chemical binding]; other site
440085002896	catalytic site [active]
440085002897	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
440085002898	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
440085002899	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
440085002900	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
440085002901	Predicted permease [General function prediction only]; Region: COG2985
440085002902	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
440085002903	TrkA-C domain; Region: TrkA_C; pfam02080
440085002904	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
440085002905	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
440085002906	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
440085002907	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
440085002908	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
440085002909	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
440085002910	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085002911	putative phosphoketolase; Provisional; Region: PRK05261
440085002912	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
440085002913	TPP-binding site; other site
440085002914	XFP C-terminal domain; Region: XFP_C; pfam09363
440085002915	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
440085002916	Helix-turn-helix domain; Region: HTH_18; pfam12833
440085002917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085002918	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
440085002919	Helix-turn-helix domain; Region: HTH_18; pfam12833
440085002920	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085002921	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
440085002922	primary metal binding site; other site
440085002923	catalytic residues [active]
440085002924	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
440085002925	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
440085002926	Sulfate transporter family; Region: Sulfate_transp; pfam00916
440085002927	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
440085002928	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
440085002929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085002930	Coenzyme A binding pocket [chemical binding]; other site
440085002931	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
440085002932	phosphate acetyltransferase; Provisional; Region: PRK11890
440085002933	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
440085002934	propionate/acetate kinase; Provisional; Region: PRK12379
440085002935	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
440085002936	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085002937	HlyD family secretion protein; Region: HlyD; pfam00529
440085002938	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085002939	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
440085002940	Predicted transporter component [General function prediction only]; Region: COG2391
440085002941	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
440085002942	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085002943	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085002944	dimerization interface [polypeptide binding]; other site
440085002945	putative Zn2+ binding site [ion binding]; other site
440085002946	putative DNA binding site [nucleotide binding]; other site
440085002947	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085002948	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085002949	Walker A/P-loop; other site
440085002950	ATP binding site [chemical binding]; other site
440085002951	Q-loop/lid; other site
440085002952	ABC transporter signature motif; other site
440085002953	Walker B; other site
440085002954	D-loop; other site
440085002955	H-loop/switch region; other site
440085002956	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085002957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085002958	dimer interface [polypeptide binding]; other site
440085002959	conserved gate region; other site
440085002960	putative PBP binding loops; other site
440085002961	ABC-ATPase subunit interface; other site
440085002962	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085002963	NMT1-like family; Region: NMT1_2; pfam13379
440085002964	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
440085002965	Rubredoxin; Region: Rubredoxin; pfam00301
440085002966	iron binding site [ion binding]; other site
440085002967	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
440085002968	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085002969	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085002970	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085002971	OsmC-like protein; Region: OsmC; pfam02566
440085002972	Nif-specific regulatory protein; Region: nifA; TIGR01817
440085002973	GAF domain; Region: GAF; pfam01590
440085002974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085002975	Walker A motif; other site
440085002976	ATP binding site [chemical binding]; other site
440085002977	Walker B motif; other site
440085002978	arginine finger; other site
440085002979	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085002980	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085002981	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
440085002982	conserved cys residue [active]
440085002983	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085002984	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
440085002985	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
440085002986	conserved cys residue [active]
440085002987	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
440085002988	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
440085002989	Na binding site [ion binding]; other site
440085002990	Protein of unknown function, DUF485; Region: DUF485; pfam04341
440085002991	Predicted amidohydrolase [General function prediction only]; Region: COG0388
440085002992	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
440085002993	putative active site [active]
440085002994	catalytic triad [active]
440085002995	putative dimer interface [polypeptide binding]; other site
440085002996	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085002997	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085002998	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085002999	dimerization interface [polypeptide binding]; other site
440085003000	RNA polymerase sigma factor; Provisional; Region: PRK12547
440085003001	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085003002	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085003003	DNA binding residues [nucleotide binding]
440085003004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085003005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085003006	non-specific DNA binding site [nucleotide binding]; other site
440085003007	salt bridge; other site
440085003008	sequence-specific DNA binding site [nucleotide binding]; other site
440085003009	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
440085003010	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
440085003011	Walker A/P-loop; other site
440085003012	ATP binding site [chemical binding]; other site
440085003013	Q-loop/lid; other site
440085003014	ABC transporter signature motif; other site
440085003015	Walker B; other site
440085003016	D-loop; other site
440085003017	H-loop/switch region; other site
440085003018	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
440085003019	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085003020	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085003021	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
440085003022	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
440085003023	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
440085003024	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
440085003025	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
440085003026	DXD motif; other site
440085003027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085003028	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
440085003029	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085003030	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085003031	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085003032	Walker A/P-loop; other site
440085003033	ATP binding site [chemical binding]; other site
440085003034	Q-loop/lid; other site
440085003035	ABC transporter signature motif; other site
440085003036	Walker B; other site
440085003037	D-loop; other site
440085003038	H-loop/switch region; other site
440085003039	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085003040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085003041	dimer interface [polypeptide binding]; other site
440085003042	conserved gate region; other site
440085003043	putative PBP binding loops; other site
440085003044	ABC-ATPase subunit interface; other site
440085003045	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085003046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
440085003047	substrate binding pocket [chemical binding]; other site
440085003048	membrane-bound complex binding site; other site
440085003049	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
440085003050	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
440085003051	active site
440085003052	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
440085003053	active site
440085003054	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
440085003055	dimer interface [polypeptide binding]; other site
440085003056	non-prolyl cis peptide bond; other site
440085003057	insertion regions; other site
440085003058	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085003059	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085003060	membrane-bound complex binding site; other site
440085003061	hinge residues; other site
440085003062	Cupin domain; Region: Cupin_2; cl17218
440085003063	serine acetyltransferase; Provisional; Region: cysE; PRK11132
440085003064	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
440085003065	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
440085003066	trimer interface [polypeptide binding]; other site
440085003067	active site
440085003068	substrate binding site [chemical binding]; other site
440085003069	CoA binding site [chemical binding]; other site
440085003070	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085003071	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085003072	ligand binding site [chemical binding]; other site
440085003073	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
440085003074	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
440085003075	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085003076	catalytic residue [active]
440085003077	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
440085003078	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085003079	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
440085003080	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
440085003081	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
440085003082	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085003083	DNA-binding site [nucleotide binding]; DNA binding site
440085003084	RNA-binding motif; other site
440085003085	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
440085003086	GAF domain; Region: GAF; pfam01590
440085003087	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085003088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003089	PAS domain; Region: PAS_9; pfam13426
440085003090	putative active site [active]
440085003091	heme pocket [chemical binding]; other site
440085003092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003093	PAS domain; Region: PAS_9; pfam13426
440085003094	putative active site [active]
440085003095	heme pocket [chemical binding]; other site
440085003096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003097	PAS fold; Region: PAS_3; pfam08447
440085003098	putative active site [active]
440085003099	heme pocket [chemical binding]; other site
440085003100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003101	PAS fold; Region: PAS_3; pfam08447
440085003102	putative active site [active]
440085003103	heme pocket [chemical binding]; other site
440085003104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003105	PAS fold; Region: PAS_3; pfam08447
440085003106	putative active site [active]
440085003107	heme pocket [chemical binding]; other site
440085003108	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085003109	HWE histidine kinase; Region: HWE_HK; pfam07536
440085003110	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
440085003111	myosin-cross-reactive antigen; Provisional; Region: PRK13977
440085003112	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
440085003113	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
440085003114	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
440085003115	dimer interface [polypeptide binding]; other site
440085003116	catalytic residues [active]
440085003117	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
440085003118	UreF; Region: UreF; pfam01730
440085003119	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
440085003120	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
440085003121	alpha-gamma subunit interface [polypeptide binding]; other site
440085003122	beta-gamma subunit interface [polypeptide binding]; other site
440085003123	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
440085003124	alpha-beta subunit interface [polypeptide binding]; other site
440085003125	urease subunit alpha; Reviewed; Region: ureC; PRK13308
440085003126	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
440085003127	subunit interactions [polypeptide binding]; other site
440085003128	active site
440085003129	flap region; other site
440085003130	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085003131	UreD urease accessory protein; Region: UreD; pfam01774
440085003132	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085003133	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
440085003134	putative ligand binding site [chemical binding]; other site
440085003135	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085003136	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085003137	N-terminal plug; other site
440085003138	ligand-binding site [chemical binding]; other site
440085003139	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
440085003140	SnoaL-like domain; Region: SnoaL_2; pfam12680
440085003141	OsmC-like protein; Region: OsmC; pfam02566
440085003142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003143	PAS domain; Region: PAS_9; pfam13426
440085003144	putative active site [active]
440085003145	heme pocket [chemical binding]; other site
440085003146	formyl-coenzyme A transferase; Provisional; Region: PRK05398
440085003147	CoA-transferase family III; Region: CoA_transf_3; pfam02515
440085003148	Predicted esterase [General function prediction only]; Region: COG0400
440085003149	putative hydrolase; Provisional; Region: PRK11460
440085003150	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
440085003151	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085003152	PYR/PP interface [polypeptide binding]; other site
440085003153	dimer interface [polypeptide binding]; other site
440085003154	TPP binding site [chemical binding]; other site
440085003155	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085003156	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
440085003157	TPP-binding site; other site
440085003158	dimer interface [polypeptide binding]; other site
440085003159	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
440085003160	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085003161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085003162	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085003163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085003164	putative substrate translocation pore; other site
440085003165	FOG: CBS domain [General function prediction only]; Region: COG0517
440085003166	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
440085003167	Zeta toxin; Region: Zeta_toxin; pfam06414
440085003168	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853
440085003169	formyl-coenzyme A transferase; Provisional; Region: PRK05398
440085003170	CoA-transferase family III; Region: CoA_transf_3; pfam02515
440085003171	Transcriptional regulators [Transcription]; Region: GntR; COG1802
440085003172	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085003173	DNA-binding site [nucleotide binding]; DNA binding site
440085003174	FCD domain; Region: FCD; pfam07729
440085003175	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
440085003176	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085003177	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
440085003178	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
440085003179	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
440085003180	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
440085003181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085003182	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
440085003183	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
440085003184	active site
440085003185	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
440085003186	Ligand Binding Site [chemical binding]; other site
440085003187	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
440085003188	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085003189	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085003190	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
440085003191	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085003192	active site
440085003193	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
440085003194	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085003195	putative ADP-binding pocket [chemical binding]; other site
440085003196	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
440085003197	regulatory protein interface [polypeptide binding]; other site
440085003198	active site
440085003199	regulatory phosphorylation site [posttranslational modification]; other site
440085003200	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
440085003201	active pocket/dimerization site; other site
440085003202	active site
440085003203	phosphorylation site [posttranslational modification]
440085003204	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
440085003205	active site
440085003206	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
440085003207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085003208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085003209	dimerization interface [polypeptide binding]; other site
440085003210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085003211	dimer interface [polypeptide binding]; other site
440085003212	phosphorylation site [posttranslational modification]
440085003213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003214	ATP binding site [chemical binding]; other site
440085003215	Mg2+ binding site [ion binding]; other site
440085003216	G-X-G motif; other site
440085003217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085003218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003219	active site
440085003220	phosphorylation site [posttranslational modification]
440085003221	intermolecular recognition site; other site
440085003222	dimerization interface [polypeptide binding]; other site
440085003223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085003224	DNA binding site [nucleotide binding]
440085003225	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
440085003226	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
440085003227	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
440085003228	GTP-binding protein LepA; Provisional; Region: PRK05433
440085003229	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
440085003230	G1 box; other site
440085003231	putative GEF interaction site [polypeptide binding]; other site
440085003232	GTP/Mg2+ binding site [chemical binding]; other site
440085003233	Switch I region; other site
440085003234	G2 box; other site
440085003235	G3 box; other site
440085003236	Switch II region; other site
440085003237	G4 box; other site
440085003238	G5 box; other site
440085003239	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
440085003240	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
440085003241	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
440085003242	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085003243	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085003244	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085003245	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
440085003246	Transglycosylase; Region: Transgly; pfam00912
440085003247	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
440085003248	flagellin; Reviewed; Region: PRK12688
440085003249	flagellin; Reviewed; Region: PRK12688
440085003250	Flagellar protein FlbT; Region: FlbT; pfam07378
440085003251	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
440085003252	Predicted membrane protein [Function unknown]; Region: COG4763
440085003253	Acyltransferase family; Region: Acyl_transf_3; pfam01757
440085003254	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
440085003255	HD domain; Region: HD_5; pfam13487
440085003256	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
440085003257	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085003258	Zn2+ binding site [ion binding]; other site
440085003259	Mg2+ binding site [ion binding]; other site
440085003260	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
440085003261	Putative phosphatase (DUF442); Region: DUF442; cl17385
440085003262	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
440085003263	active site
440085003264	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
440085003265	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085003266	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
440085003267	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085003268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003269	active site
440085003270	phosphorylation site [posttranslational modification]
440085003271	intermolecular recognition site; other site
440085003272	dimerization interface [polypeptide binding]; other site
440085003273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085003274	Walker A motif; other site
440085003275	ATP binding site [chemical binding]; other site
440085003276	Walker B motif; other site
440085003277	arginine finger; other site
440085003278	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085003279	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
440085003280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085003281	dimer interface [polypeptide binding]; other site
440085003282	phosphorylation site [posttranslational modification]
440085003283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003284	ATP binding site [chemical binding]; other site
440085003285	Mg2+ binding site [ion binding]; other site
440085003286	G-X-G motif; other site
440085003287	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085003288	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085003289	Walker A/P-loop; other site
440085003290	ATP binding site [chemical binding]; other site
440085003291	Q-loop/lid; other site
440085003292	ABC transporter signature motif; other site
440085003293	Walker B; other site
440085003294	D-loop; other site
440085003295	H-loop/switch region; other site
440085003296	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085003297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085003298	dimer interface [polypeptide binding]; other site
440085003299	conserved gate region; other site
440085003300	putative PBP binding loops; other site
440085003301	ABC-ATPase subunit interface; other site
440085003302	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085003303	NMT1/THI5 like; Region: NMT1; pfam09084
440085003304	substrate binding pocket [chemical binding]; other site
440085003305	membrane-bound complex binding site; other site
440085003306	septum formation inhibitor; Reviewed; Region: minC; PRK05177
440085003307	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
440085003308	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
440085003309	Predicted membrane protein [Function unknown]; Region: COG4325
440085003310	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
440085003311	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
440085003312	G1 box; other site
440085003313	putative GEF interaction site [polypeptide binding]; other site
440085003314	GTP/Mg2+ binding site [chemical binding]; other site
440085003315	Switch I region; other site
440085003316	G2 box; other site
440085003317	G3 box; other site
440085003318	Switch II region; other site
440085003319	G4 box; other site
440085003320	G5 box; other site
440085003321	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
440085003322	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
440085003323	CHASE3 domain; Region: CHASE3; pfam05227
440085003324	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085003325	dimer interface [polypeptide binding]; other site
440085003326	putative CheW interface [polypeptide binding]; other site
440085003327	septum formation inhibitor; Reviewed; Region: minC; PRK05177
440085003328	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
440085003329	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
440085003330	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
440085003331	Switch I; other site
440085003332	Switch II; other site
440085003333	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
440085003334	Cytochrome P450; Region: p450; cl12078
440085003335	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
440085003336	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
440085003337	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
440085003338	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
440085003339	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
440085003340	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
440085003341	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
440085003342	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
440085003343	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
440085003344	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
440085003345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085003346	dimer interface [polypeptide binding]; other site
440085003347	conserved gate region; other site
440085003348	putative PBP binding loops; other site
440085003349	ABC-ATPase subunit interface; other site
440085003350	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
440085003351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085003352	dimer interface [polypeptide binding]; other site
440085003353	conserved gate region; other site
440085003354	putative PBP binding loops; other site
440085003355	ABC-ATPase subunit interface; other site
440085003356	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
440085003357	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085003358	Walker A/P-loop; other site
440085003359	ATP binding site [chemical binding]; other site
440085003360	Q-loop/lid; other site
440085003361	ABC transporter signature motif; other site
440085003362	Walker B; other site
440085003363	D-loop; other site
440085003364	H-loop/switch region; other site
440085003365	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085003366	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085003367	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
440085003368	Walker A/P-loop; other site
440085003369	ATP binding site [chemical binding]; other site
440085003370	Q-loop/lid; other site
440085003371	ABC transporter signature motif; other site
440085003372	Walker B; other site
440085003373	D-loop; other site
440085003374	H-loop/switch region; other site
440085003375	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085003376	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
440085003377	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
440085003378	tetrameric interface [polypeptide binding]; other site
440085003379	NAD binding site [chemical binding]; other site
440085003380	catalytic residues [active]
440085003381	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
440085003382	putative hydrophobic ligand binding site [chemical binding]; other site
440085003383	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
440085003384	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
440085003385	Walker A/P-loop; other site
440085003386	ATP binding site [chemical binding]; other site
440085003387	Q-loop/lid; other site
440085003388	ABC transporter signature motif; other site
440085003389	Walker B; other site
440085003390	D-loop; other site
440085003391	H-loop/switch region; other site
440085003392	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
440085003393	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
440085003394	Walker A/P-loop; other site
440085003395	ATP binding site [chemical binding]; other site
440085003396	Q-loop/lid; other site
440085003397	ABC transporter signature motif; other site
440085003398	Walker B; other site
440085003399	D-loop; other site
440085003400	H-loop/switch region; other site
440085003401	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
440085003402	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
440085003403	TM-ABC transporter signature motif; other site
440085003404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085003405	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
440085003406	TM-ABC transporter signature motif; other site
440085003407	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085003408	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
440085003409	putative ligand binding site [chemical binding]; other site
440085003410	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085003411	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085003412	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085003413	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
440085003414	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085003415	catalytic loop [active]
440085003416	iron binding site [ion binding]; other site
440085003417	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085003418	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
440085003419	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
440085003420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085003421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085003422	allantoate amidohydrolase; Reviewed; Region: PRK09290
440085003423	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
440085003424	active site
440085003425	metal binding site [ion binding]; metal-binding site
440085003426	dimer interface [polypeptide binding]; other site
440085003427	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
440085003428	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
440085003429	inhibitor-cofactor binding pocket; inhibition site
440085003430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085003431	catalytic residue [active]
440085003432	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
440085003433	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
440085003434	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085003435	ATP binding site [chemical binding]; other site
440085003436	putative Mg++ binding site [ion binding]; other site
440085003437	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085003438	nucleotide binding region [chemical binding]; other site
440085003439	ATP-binding site [chemical binding]; other site
440085003440	TRCF domain; Region: TRCF; pfam03461
440085003441	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
440085003442	urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441
440085003443	UreD urease accessory protein; Region: UreD; pfam01774
440085003444	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
440085003445	G1 box; other site
440085003446	GTP/Mg2+ binding site [chemical binding]; other site
440085003447	G2 box; other site
440085003448	Switch I region; other site
440085003449	Switch II region; other site
440085003450	G4 box; other site
440085003451	G5 box; other site
440085003452	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
440085003453	UreF; Region: UreF; pfam01730
440085003454	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
440085003455	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
440085003456	dimer interface [polypeptide binding]; other site
440085003457	catalytic residues [active]
440085003458	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
440085003459	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
440085003460	urease subunit alpha; Reviewed; Region: ureC; PRK13207
440085003461	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
440085003462	subunit interactions [polypeptide binding]; other site
440085003463	active site
440085003464	flap region; other site
440085003465	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
440085003466	alpha-beta subunit interface [polypeptide binding]; other site
440085003467	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
440085003468	alpha-gamma subunit interface [polypeptide binding]; other site
440085003469	beta-gamma subunit interface [polypeptide binding]; other site
440085003470	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085003471	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
440085003472	Protein of unknown function DUF72; Region: DUF72; pfam01904
440085003473	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085003474	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
440085003475	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085003476	Zn2+ binding site [ion binding]; other site
440085003477	Mg2+ binding site [ion binding]; other site
440085003478	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085003479	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
440085003480	conserved cys residue [active]
440085003481	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085003482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085003483	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
440085003484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085003485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003486	ATP binding site [chemical binding]; other site
440085003487	Mg2+ binding site [ion binding]; other site
440085003488	G-X-G motif; other site
440085003489	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
440085003490	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
440085003491	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
440085003492	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085003493	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
440085003494	DNA binding residues [nucleotide binding]
440085003495	dimerization interface [polypeptide binding]; other site
440085003496	HTH-like domain; Region: HTH_21; pfam13276
440085003497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
440085003498	Integrase core domain; Region: rve; pfam00665
440085003499	Integrase core domain; Region: rve_3; pfam13683
440085003500	Transposase; Region: HTH_Tnp_1; cl17663
440085003501	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
440085003502	Sel1-like repeats; Region: SEL1; smart00671
440085003503	Sel1-like repeats; Region: SEL1; smart00671
440085003504	Sel1-like repeats; Region: SEL1; smart00671
440085003505	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
440085003506	iron-sulfur cluster [ion binding]; other site
440085003507	[2Fe-2S] cluster binding site [ion binding]; other site
440085003508	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
440085003509	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
440085003510	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
440085003511	Walker A/P-loop; other site
440085003512	ATP binding site [chemical binding]; other site
440085003513	Q-loop/lid; other site
440085003514	ABC transporter signature motif; other site
440085003515	Walker B; other site
440085003516	D-loop; other site
440085003517	H-loop/switch region; other site
440085003518	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
440085003519	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
440085003520	Walker A/P-loop; other site
440085003521	ATP binding site [chemical binding]; other site
440085003522	Q-loop/lid; other site
440085003523	ABC transporter signature motif; other site
440085003524	Walker B; other site
440085003525	D-loop; other site
440085003526	H-loop/switch region; other site
440085003527	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
440085003528	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
440085003529	TM-ABC transporter signature motif; other site
440085003530	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
440085003531	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085003532	TM-ABC transporter signature motif; other site
440085003533	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085003534	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
440085003535	ligand binding site [chemical binding]; other site
440085003536	SnoaL-like domain; Region: SnoaL_2; pfam12680
440085003537	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
440085003538	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
440085003539	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085003540	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
440085003541	catalytic site [active]
440085003542	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
440085003543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
440085003544	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
440085003545	short chain dehydrogenase; Provisional; Region: PRK05993
440085003546	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
440085003547	NADP binding site [chemical binding]; other site
440085003548	active site
440085003549	steroid binding site; other site
440085003550	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085003551	catalytic core [active]
440085003552	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
440085003553	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
440085003554	classical (c) SDRs; Region: SDR_c; cd05233
440085003555	NAD(P) binding site [chemical binding]; other site
440085003556	active site
440085003557	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
440085003558	PAS domain S-box; Region: sensory_box; TIGR00229
440085003559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003560	putative active site [active]
440085003561	heme pocket [chemical binding]; other site
440085003562	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085003563	GAF domain; Region: GAF; pfam01590
440085003564	GAF domain; Region: GAF; pfam01590
440085003565	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
440085003566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003567	putative active site [active]
440085003568	heme pocket [chemical binding]; other site
440085003569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085003570	dimer interface [polypeptide binding]; other site
440085003571	phosphorylation site [posttranslational modification]
440085003572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003573	ATP binding site [chemical binding]; other site
440085003574	Mg2+ binding site [ion binding]; other site
440085003575	G-X-G motif; other site
440085003576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003577	Response regulator receiver domain; Region: Response_reg; pfam00072
440085003578	active site
440085003579	phosphorylation site [posttranslational modification]
440085003580	intermolecular recognition site; other site
440085003581	dimerization interface [polypeptide binding]; other site
440085003582	Cytochrome P450; Region: p450; cl12078
440085003583	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
440085003584	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003585	PAS domain; Region: PAS_9; pfam13426
440085003586	putative active site [active]
440085003587	heme pocket [chemical binding]; other site
440085003588	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085003589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085003590	metal binding site [ion binding]; metal-binding site
440085003591	active site
440085003592	I-site; other site
440085003593	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085003594	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
440085003595	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
440085003596	ApbE family; Region: ApbE; pfam02424
440085003597	FMN-binding domain; Region: FMN_bind; cl01081
440085003598	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
440085003599	4Fe-4S binding domain; Region: Fer4_5; pfam12801
440085003600	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
440085003601	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085003602	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085003603	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085003604	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
440085003605	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085003606	ligand binding site [chemical binding]; other site
440085003607	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
440085003608	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
440085003609	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085003610	substrate binding pocket [chemical binding]; other site
440085003611	membrane-bound complex binding site; other site
440085003612	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
440085003613	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
440085003614	dimer interface [polypeptide binding]; other site
440085003615	Trp docking motif [polypeptide binding]; other site
440085003616	active site
440085003617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085003618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085003619	putative substrate translocation pore; other site
440085003620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085003621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
440085003622	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
440085003623	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
440085003624	short chain dehydrogenase; Provisional; Region: PRK06172
440085003625	classical (c) SDRs; Region: SDR_c; cd05233
440085003626	NAD(P) binding site [chemical binding]; other site
440085003627	active site
440085003628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085003629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085003630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085003631	dimerization interface [polypeptide binding]; other site
440085003632	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
440085003633	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085003634	Ligand Binding Site [chemical binding]; other site
440085003635	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
440085003636	Cytochrome c; Region: Cytochrom_C; pfam00034
440085003637	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085003638	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085003639	ligand binding site [chemical binding]; other site
440085003640	flexible hinge region; other site
440085003641	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085003642	putative switch regulator; other site
440085003643	non-specific DNA interactions [nucleotide binding]; other site
440085003644	DNA binding site [nucleotide binding]
440085003645	sequence specific DNA binding site [nucleotide binding]; other site
440085003646	putative cAMP binding site [chemical binding]; other site
440085003647	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
440085003648	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
440085003649	Walker A/P-loop; other site
440085003650	ATP binding site [chemical binding]; other site
440085003651	Q-loop/lid; other site
440085003652	ABC transporter signature motif; other site
440085003653	Walker B; other site
440085003654	D-loop; other site
440085003655	H-loop/switch region; other site
440085003656	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
440085003657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085003658	Walker A/P-loop; other site
440085003659	ATP binding site [chemical binding]; other site
440085003660	Q-loop/lid; other site
440085003661	ABC transporter signature motif; other site
440085003662	Walker B; other site
440085003663	D-loop; other site
440085003664	H-loop/switch region; other site
440085003665	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
440085003666	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
440085003667	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
440085003668	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
440085003669	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
440085003670	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
440085003671	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
440085003672	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
440085003673	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
440085003674	Amidase; Region: Amidase; cl11426
440085003675	Response regulator receiver domain; Region: Response_reg; pfam00072
440085003676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003677	active site
440085003678	phosphorylation site [posttranslational modification]
440085003679	intermolecular recognition site; other site
440085003680	dimerization interface [polypeptide binding]; other site
440085003681	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
440085003682	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
440085003683	DXD motif; other site
440085003684	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
440085003685	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
440085003686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
440085003687	TPR motif; other site
440085003688	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
440085003689	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085003690	TIGR02594 family protein; Region: TIGR02594
440085003691	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
440085003692	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
440085003693	Phage-related minor tail protein [Function unknown]; Region: COG5281
440085003694	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085003695	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085003696	catalytic residue [active]
440085003697	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
440085003698	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
440085003699	Phage capsid family; Region: Phage_capsid; pfam05065
440085003700	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
440085003701	Phage-related protein [Function unknown]; Region: COG4695
440085003702	Phage portal protein; Region: Phage_portal; pfam04860
440085003703	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
440085003704	Terminase small subunit; Region: Terminase_2; pfam03592
440085003705	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
440085003706	active site
440085003707	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085003708	MT-A70; Region: MT-A70; cl01947
440085003709	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
440085003710	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
440085003711	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
440085003712	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085003713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085003714	non-specific DNA binding site [nucleotide binding]; other site
440085003715	salt bridge; other site
440085003716	sequence-specific DNA binding site [nucleotide binding]; other site
440085003717	Predicted transcriptional regulator [Transcription]; Region: COG2932
440085003718	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
440085003719	Catalytic site [active]
440085003720	recombination endonuclease VII; Provisional; Region: 49; PHA02565
440085003721	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085003722	non-specific DNA binding site [nucleotide binding]; other site
440085003723	salt bridge; other site
440085003724	sequence-specific DNA binding site [nucleotide binding]; other site
440085003725	Helix-turn-helix domain; Region: HTH_17; pfam12728
440085003726	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085003727	active site
440085003728	catalytic residues [active]
440085003729	DNA binding site [nucleotide binding]
440085003730	Int/Topo IB signature motif; other site
440085003731	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
440085003732	Putative zinc-finger; Region: zf-HC2; pfam13490
440085003733	RNA polymerase sigma factor; Provisional; Region: PRK12511
440085003734	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085003735	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085003736	DNA binding residues [nucleotide binding]
440085003737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
440085003738	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085003739	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085003740	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
440085003741	Protein of unknown function (DUF461); Region: DUF461; pfam04314
440085003742	Protein of unknown function (DUF461); Region: DUF461; pfam04314
440085003743	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
440085003744	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
440085003745	Cu(I) binding site [ion binding]; other site
440085003746	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085003747	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085003748	N-terminal plug; other site
440085003749	ligand-binding site [chemical binding]; other site
440085003750	Caspase domain; Region: Peptidase_C14; pfam00656
440085003751	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
440085003752	Transcriptional regulators [Transcription]; Region: GntR; COG1802
440085003753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085003754	DNA-binding site [nucleotide binding]; DNA binding site
440085003755	FCD domain; Region: FCD; pfam07729
440085003756	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
440085003757	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
440085003758	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
440085003759	DctM-like transporters; Region: DctM; pfam06808
440085003760	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
440085003761	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
440085003762	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
440085003763	dimer interface [polypeptide binding]; other site
440085003764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085003765	catalytic residue [active]
440085003766	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
440085003767	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085003768	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
440085003769	MG2 domain; Region: A2M_N; pfam01835
440085003770	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
440085003771	surface patch; other site
440085003772	thioester region; other site
440085003773	specificity defining residues; other site
440085003774	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
440085003775	Transglycosylase; Region: Transgly; pfam00912
440085003776	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
440085003777	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
440085003778	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
440085003779	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085003780	non-specific DNA binding site [nucleotide binding]; other site
440085003781	salt bridge; other site
440085003782	sequence-specific DNA binding site [nucleotide binding]; other site
440085003783	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
440085003784	active site
440085003785	catalytic site [active]
440085003786	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
440085003787	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
440085003788	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
440085003789	metal ion-dependent adhesion site (MIDAS); other site
440085003790	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085003791	catalytic core [active]
440085003792	High-affinity nickel-transport protein; Region: NicO; cl00964
440085003793	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
440085003794	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
440085003795	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
440085003796	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
440085003797	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
440085003798	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
440085003799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
440085003800	TPR motif; other site
440085003801	binding surface
440085003802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
440085003803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003804	ATP binding site [chemical binding]; other site
440085003805	Mg2+ binding site [ion binding]; other site
440085003806	G-X-G motif; other site
440085003807	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085003808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003809	active site
440085003810	phosphorylation site [posttranslational modification]
440085003811	intermolecular recognition site; other site
440085003812	dimerization interface [polypeptide binding]; other site
440085003813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085003814	DNA binding site [nucleotide binding]
440085003815	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
440085003816	catalytic residues [active]
440085003817	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
440085003818	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
440085003819	Putative phage tail protein; Region: Phage-tail_3; pfam13550
440085003820	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
440085003821	NlpC/P60 family; Region: NLPC_P60; cl17555
440085003822	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
440085003823	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
440085003824	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
440085003825	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
440085003826	Phage-related minor tail protein [Function unknown]; Region: COG5281
440085003827	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
440085003828	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
440085003829	Phage major tail protein 2; Region: Phage_tail_2; cl11463
440085003830	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
440085003831	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
440085003832	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
440085003833	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
440085003834	cleavage site
440085003835	active site
440085003836	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
440085003837	active site
440085003838	substrate binding sites [chemical binding]; other site
440085003839	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
440085003840	Phage capsid family; Region: Phage_capsid; pfam05065
440085003841	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
440085003842	Phage-related protein [Function unknown]; Region: COG4695
440085003843	Phage portal protein; Region: Phage_portal; pfam04860
440085003844	Uncharacterized conserved protein [Function unknown]; Region: COG5323
440085003845	Terminase-like family; Region: Terminase_6; pfam03237
440085003846	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
440085003847	active site
440085003848	SAM binding site [chemical binding]; other site
440085003849	homodimer interface [polypeptide binding]; other site
440085003850	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
440085003851	active site
440085003852	SAM binding site [chemical binding]; other site
440085003853	homodimer interface [polypeptide binding]; other site
440085003854	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
440085003855	Precorrin-8X methylmutase; Region: CbiC; pfam02570
440085003856	precorrin-3B synthase; Region: CobG; TIGR02435
440085003857	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
440085003858	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
440085003859	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
440085003860	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
440085003861	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
440085003862	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
440085003863	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
440085003864	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
440085003865	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
440085003866	cobalt transporter subunit CbtA (proposed); Region: CbtA; TIGR02458
440085003867	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
440085003868	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
440085003869	MarR family; Region: MarR_2; pfam12802
440085003870	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
440085003871	homotrimer interface [polypeptide binding]; other site
440085003872	Walker A motif; other site
440085003873	GTP binding site [chemical binding]; other site
440085003874	Walker B motif; other site
440085003875	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
440085003876	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
440085003877	fumarate hydratase; Reviewed; Region: fumC; PRK00485
440085003878	Class II fumarases; Region: Fumarase_classII; cd01362
440085003879	active site
440085003880	tetramer interface [polypeptide binding]; other site
440085003881	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
440085003882	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085003883	HAMP domain; Region: HAMP; pfam00672
440085003884	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085003885	dimer interface [polypeptide binding]; other site
440085003886	putative CheW interface [polypeptide binding]; other site
440085003887	PAS fold; Region: PAS_4; pfam08448
440085003888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
440085003889	PAS fold; Region: PAS_3; pfam08447
440085003890	putative active site [active]
440085003891	heme pocket [chemical binding]; other site
440085003892	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003893	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085003894	putative active site [active]
440085003895	heme pocket [chemical binding]; other site
440085003896	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085003897	putative active site [active]
440085003898	heme pocket [chemical binding]; other site
440085003899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085003900	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085003901	dimer interface [polypeptide binding]; other site
440085003902	phosphorylation site [posttranslational modification]
440085003903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085003904	ATP binding site [chemical binding]; other site
440085003905	Mg2+ binding site [ion binding]; other site
440085003906	G-X-G motif; other site
440085003907	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085003908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085003909	active site
440085003910	phosphorylation site [posttranslational modification]
440085003911	intermolecular recognition site; other site
440085003912	dimerization interface [polypeptide binding]; other site
440085003913	EamA-like transporter family; Region: EamA; pfam00892
440085003914	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
440085003915	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
440085003916	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085003917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085003918	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
440085003919	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
440085003920	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
440085003921	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
440085003922	Protein of unknown function DUF58; Region: DUF58; pfam01882
440085003923	MoxR-like ATPases [General function prediction only]; Region: COG0714
440085003924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085003925	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
440085003926	CoenzymeA binding site [chemical binding]; other site
440085003927	subunit interaction site [polypeptide binding]; other site
440085003928	PHB binding site; other site
440085003929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
440085003930	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
440085003931	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
440085003932	putative active site [active]
440085003933	putative CoA binding site [chemical binding]; other site
440085003934	nudix motif; other site
440085003935	metal binding site [ion binding]; metal-binding site
440085003936	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
440085003937	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
440085003938	active site
440085003939	NTP binding site [chemical binding]; other site
440085003940	metal binding triad [ion binding]; metal-binding site
440085003941	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
440085003942	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736
440085003943	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
440085003944	gamma subunit interface [polypeptide binding]; other site
440085003945	epsilon subunit interface [polypeptide binding]; other site
440085003946	LBP interface [polypeptide binding]; other site
440085003947	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
440085003948	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
440085003949	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
440085003950	alpha subunit interaction interface [polypeptide binding]; other site
440085003951	Walker A motif; other site
440085003952	ATP binding site [chemical binding]; other site
440085003953	Walker B motif; other site
440085003954	inhibitor binding site; inhibition site
440085003955	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
440085003956	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
440085003957	core domain interface [polypeptide binding]; other site
440085003958	delta subunit interface [polypeptide binding]; other site
440085003959	epsilon subunit interface [polypeptide binding]; other site
440085003960	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
440085003961	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
440085003962	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
440085003963	beta subunit interaction interface [polypeptide binding]; other site
440085003964	Walker A motif; other site
440085003965	ATP binding site [chemical binding]; other site
440085003966	Walker B motif; other site
440085003967	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
440085003968	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
440085003969	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
440085003970	ferrochelatase; Reviewed; Region: hemH; PRK00035
440085003971	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
440085003972	C-terminal domain interface [polypeptide binding]; other site
440085003973	active site
440085003974	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
440085003975	active site
440085003976	N-terminal domain interface [polypeptide binding]; other site
440085003977	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085003978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085003979	S-adenosylmethionine binding site [chemical binding]; other site
440085003980	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085003981	active site
440085003982	metal binding site [ion binding]; metal-binding site
440085003983	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
440085003984	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
440085003985	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
440085003986	ligand binding site [chemical binding]; other site
440085003987	active site
440085003988	UGI interface [polypeptide binding]; other site
440085003989	catalytic site [active]
440085003990	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
440085003991	active site residue [active]
440085003992	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
440085003993	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
440085003994	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
440085003995	Chromate transporter; Region: Chromate_transp; pfam02417
440085003996	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
440085003997	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
440085003998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
440085003999	ATP binding site [chemical binding]; other site
440085004000	putative Mg++ binding site [ion binding]; other site
440085004001	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
440085004002	SEC-C motif; Region: SEC-C; pfam02810
440085004003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085004004	Coenzyme A binding pocket [chemical binding]; other site
440085004005	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
440085004006	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
440085004007	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
440085004008	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
440085004009	nudix motif; other site
440085004010	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
440085004011	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
440085004012	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
440085004013	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
440085004014	active site
440085004015	catalytic site [active]
440085004016	substrate binding site [chemical binding]; other site
440085004017	Protein of unknown function (DUF497); Region: DUF497; pfam04365
440085004018	Predicted transcriptional regulator [Transcription]; Region: COG2944
440085004019	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085004020	non-specific DNA binding site [nucleotide binding]; other site
440085004021	salt bridge; other site
440085004022	sequence-specific DNA binding site [nucleotide binding]; other site
440085004023	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
440085004024	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
440085004025	CoA-binding site [chemical binding]; other site
440085004026	ATP-binding [chemical binding]; other site
440085004027	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
440085004028	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
440085004029	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
440085004030	NAD(P) binding site [chemical binding]; other site
440085004031	shikimate binding site; other site
440085004032	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
440085004033	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
440085004034	putative active site [active]
440085004035	Protein of unknown function (DUF563); Region: DUF563; pfam04577
440085004036	PEP synthetase regulatory protein; Provisional; Region: PRK05339
440085004037	uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115
440085004038	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
440085004039	nudix motif; other site
440085004040	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
440085004041	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
440085004042	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
440085004043	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
440085004044	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
440085004045	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
440085004046	motif 1; other site
440085004047	dimer interface [polypeptide binding]; other site
440085004048	active site
440085004049	motif 2; other site
440085004050	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
440085004051	active site
440085004052	motif 3; other site
440085004053	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
440085004054	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
440085004055	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
440085004056	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085004057	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
440085004058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085004059	putative substrate translocation pore; other site
440085004060	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
440085004061	putative acyl-acceptor binding pocket; other site
440085004062	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085004063	acyl-activating enzyme (AAE) consensus motif; other site
440085004064	AMP binding site [chemical binding]; other site
440085004065	active site
440085004066	CoA binding site [chemical binding]; other site
440085004067	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
440085004068	Predicted transcriptional regulator [Transcription]; Region: COG2944
440085004069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085004070	non-specific DNA binding site [nucleotide binding]; other site
440085004071	salt bridge; other site
440085004072	sequence-specific DNA binding site [nucleotide binding]; other site
440085004073	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
440085004074	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085004075	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
440085004076	diiron binding motif [ion binding]; other site
440085004077	Uncharacterized conserved protein [Function unknown]; Region: COG1633
440085004078	CCC1-related protein family; Region: CCC1_like_1; cd02437
440085004079	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
440085004080	trimer interface [polypeptide binding]; other site
440085004081	putative metal binding site [ion binding]; other site
440085004082	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
440085004083	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
440085004084	trimer interface [polypeptide binding]; other site
440085004085	putative metal binding site [ion binding]; other site
440085004086	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
440085004087	MoaE homodimer interface [polypeptide binding]; other site
440085004088	MoaD interaction [polypeptide binding]; other site
440085004089	active site residues [active]
440085004090	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085004091	malate:quinone oxidoreductase; Validated; Region: PRK05257
440085004092	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
440085004093	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
440085004094	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
440085004095	metal ion-dependent adhesion site (MIDAS); other site
440085004096	MoxR-like ATPases [General function prediction only]; Region: COG0714
440085004097	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
440085004098	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
440085004099	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
440085004100	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
440085004101	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
440085004102	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
440085004103	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
440085004104	ligand binding site [chemical binding]; other site
440085004105	active site
440085004106	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
440085004107	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
440085004108	active site
440085004109	dimer interface [polypeptide binding]; other site
440085004110	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
440085004111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085004112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085004113	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
440085004114	trimer interface [polypeptide binding]; other site
440085004115	active site
440085004116	Protein of unknown function (DUF429); Region: DUF429; cl12046
440085004117	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
440085004118	nudix motif; other site
440085004119	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
440085004120	active site clefts [active]
440085004121	zinc binding site [ion binding]; other site
440085004122	dimer interface [polypeptide binding]; other site
440085004123	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
440085004124	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
440085004125	active site
440085004126	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
440085004127	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
440085004128	putative binding surface; other site
440085004129	active site
440085004130	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
440085004131	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
440085004132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085004133	ATP binding site [chemical binding]; other site
440085004134	Mg2+ binding site [ion binding]; other site
440085004135	G-X-G motif; other site
440085004136	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
440085004137	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085004138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004139	active site
440085004140	phosphorylation site [posttranslational modification]
440085004141	intermolecular recognition site; other site
440085004142	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
440085004143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004144	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004145	active site
440085004146	phosphorylation site [posttranslational modification]
440085004147	intermolecular recognition site; other site
440085004148	dimerization interface [polypeptide binding]; other site
440085004149	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
440085004150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004151	active site
440085004152	phosphorylation site [posttranslational modification]
440085004153	intermolecular recognition site; other site
440085004154	dimerization interface [polypeptide binding]; other site
440085004155	CheB methylesterase; Region: CheB_methylest; pfam01339
440085004156	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
440085004157	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
440085004158	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
440085004159	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
440085004160	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
440085004161	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
440085004162	UV-endonuclease UvdE; Region: UvdE; cl10036
440085004163	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
440085004164	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
440085004165	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
440085004166	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
440085004167	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
440085004168	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
440085004169	Ligand binding site [chemical binding]; other site
440085004170	Electron transfer flavoprotein domain; Region: ETF; pfam01012
440085004171	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
440085004172	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
440085004173	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
440085004174	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
440085004175	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
440085004176	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
440085004177	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
440085004178	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
440085004179	NAD(P) binding site [chemical binding]; other site
440085004180	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085004181	active site
440085004182	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
440085004183	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
440085004184	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
440085004185	active site
440085004186	catalytic site [active]
440085004187	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
440085004188	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
440085004189	active site
440085004190	homotetramer interface [polypeptide binding]; other site
440085004191	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
440085004192	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
440085004193	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
440085004194	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
440085004195	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
440085004196	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
440085004197	dimer interface [polypeptide binding]; other site
440085004198	motif 1; other site
440085004199	active site
440085004200	motif 2; other site
440085004201	motif 3; other site
440085004202	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
440085004203	anticodon binding site; other site
440085004204	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
440085004205	dimer interface [polypeptide binding]; other site
440085004206	putative tRNA-binding site [nucleotide binding]; other site
440085004207	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
440085004208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085004209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085004210	preprotein translocase subunit SecB; Validated; Region: PRK05751
440085004211	SecA binding site; other site
440085004212	Preprotein binding site; other site
440085004213	Tim44-like domain; Region: Tim44; pfam04280
440085004214	MltA specific insert domain; Region: MltA; smart00925
440085004215	3D domain; Region: 3D; pfam06725
440085004216	Smr domain; Region: Smr; pfam01713
440085004217	transcription termination factor Rho; Provisional; Region: rho; PRK09376
440085004218	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
440085004219	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
440085004220	RNA binding site [nucleotide binding]; other site
440085004221	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
440085004222	multimer interface [polypeptide binding]; other site
440085004223	Walker A motif; other site
440085004224	ATP binding site [chemical binding]; other site
440085004225	Walker B motif; other site
440085004226	pyruvate dehydrogenase; Provisional; Region: PRK09124
440085004227	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
440085004228	PYR/PP interface [polypeptide binding]; other site
440085004229	dimer interface [polypeptide binding]; other site
440085004230	tetramer interface [polypeptide binding]; other site
440085004231	TPP binding site [chemical binding]; other site
440085004232	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085004233	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
440085004234	TPP-binding site [chemical binding]; other site
440085004235	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
440085004236	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
440085004237	putative lipid kinase; Reviewed; Region: PRK13057
440085004238	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
440085004239	active site
440085004240	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
440085004241	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085004242	Predicted transcriptional regulator [Transcription]; Region: COG2944
440085004243	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085004244	non-specific DNA binding site [nucleotide binding]; other site
440085004245	salt bridge; other site
440085004246	sequence-specific DNA binding site [nucleotide binding]; other site
440085004247	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
440085004248	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
440085004249	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
440085004250	trimer interface [polypeptide binding]; other site
440085004251	active site
440085004252	substrate binding site [chemical binding]; other site
440085004253	CoA binding site [chemical binding]; other site
440085004254	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085004255	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085004256	ligand binding site [chemical binding]; other site
440085004257	flexible hinge region; other site
440085004258	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085004259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004260	active site
440085004261	phosphorylation site [posttranslational modification]
440085004262	intermolecular recognition site; other site
440085004263	dimerization interface [polypeptide binding]; other site
440085004264	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085004265	DNA binding site [nucleotide binding]
440085004266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
440085004267	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
440085004268	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
440085004269	catalytic residue [active]
440085004270	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
440085004271	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
440085004272	HIGH motif; other site
440085004273	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
440085004274	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
440085004275	active site
440085004276	KMSKS motif; other site
440085004277	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
440085004278	tRNA binding surface [nucleotide binding]; other site
440085004279	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
440085004280	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
440085004281	trmE is a tRNA modification GTPase; Region: trmE; cd04164
440085004282	G1 box; other site
440085004283	GTP/Mg2+ binding site [chemical binding]; other site
440085004284	Switch I region; other site
440085004285	G2 box; other site
440085004286	Switch II region; other site
440085004287	G3 box; other site
440085004288	G4 box; other site
440085004289	G5 box; other site
440085004290	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
440085004291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
440085004292	PAS fold; Region: PAS_3; pfam08447
440085004293	putative active site [active]
440085004294	heme pocket [chemical binding]; other site
440085004295	PAS fold; Region: PAS_3; pfam08447
440085004296	Helix-turn-helix; Region: HTH_3; pfam01381
440085004297	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
440085004298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085004299	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
440085004300	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
440085004301	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
440085004302	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
440085004303	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
440085004304	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085004305	P-loop; other site
440085004306	Magnesium ion binding site [ion binding]; other site
440085004307	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085004308	Magnesium ion binding site [ion binding]; other site
440085004309	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
440085004310	ParB-like nuclease domain; Region: ParB; smart00470
440085004311	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
440085004312	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
440085004313	Lipopolysaccharide-assembly; Region: LptE; cl01125
440085004314	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
440085004315	B-block binding subunit of TFIIIC; Region: B-block_TFIIIC; pfam04182
440085004316	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
440085004317	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
440085004318	prephenate dehydrogenase; Validated; Region: PRK08507
440085004319	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
440085004320	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085004321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085004322	homodimer interface [polypeptide binding]; other site
440085004323	catalytic residue [active]
440085004324	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
440085004325	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085004326	N-terminal plug; other site
440085004327	ligand-binding site [chemical binding]; other site
440085004328	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
440085004329	potassium uptake protein; Region: kup; TIGR00794
440085004330	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
440085004331	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
440085004332	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
440085004333	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
440085004334	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
440085004335	active site
440085004336	nucleophile elbow; other site
440085004337	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085004338	putative DNA binding site [nucleotide binding]; other site
440085004339	putative Zn2+ binding site [ion binding]; other site
440085004340	Methyltransferase domain; Region: Methyltransf_31; pfam13847
440085004341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085004342	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
440085004343	FAD binding site [chemical binding]; other site
440085004344	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
440085004345	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
440085004346	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
440085004347	substrate binding pocket [chemical binding]; other site
440085004348	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
440085004349	B12 binding site [chemical binding]; other site
440085004350	cobalt ligand [ion binding]; other site
440085004351	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
440085004352	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
440085004353	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
440085004354	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
440085004355	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
440085004356	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
440085004357	putative active site [active]
440085004358	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
440085004359	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
440085004360	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
440085004361	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
440085004362	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
440085004363	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
440085004364	ThiC-associated domain; Region: ThiC-associated; pfam13667
440085004365	ThiC family; Region: ThiC; pfam01964
440085004366	FlaG protein; Region: FlaG; cl00591
440085004367	Flagellar protein FlaF; Region: FlaF; cl11454
440085004368	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
440085004369	putative active site [active]
440085004370	putative metal binding site [ion binding]; other site
440085004371	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
440085004372	TolR protein; Region: tolR; TIGR02801
440085004373	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
440085004374	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
440085004375	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
440085004376	putative dimer interface [polypeptide binding]; other site
440085004377	Uncharacterized small protein [Function unknown]; Region: COG5568
440085004378	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085004379	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
440085004380	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
440085004381	putative ADP-binding pocket [chemical binding]; other site
440085004382	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085004383	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
440085004384	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
440085004385	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
440085004386	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
440085004387	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
440085004388	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085004389	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
440085004390	putative ADP-binding pocket [chemical binding]; other site
440085004391	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
440085004392	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
440085004393	23S rRNA binding site [nucleotide binding]; other site
440085004394	L21 binding site [polypeptide binding]; other site
440085004395	L13 binding site [polypeptide binding]; other site
440085004396	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
440085004397	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
440085004398	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
440085004399	dimer interface [polypeptide binding]; other site
440085004400	motif 1; other site
440085004401	active site
440085004402	motif 2; other site
440085004403	motif 3; other site
440085004404	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
440085004405	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
440085004406	putative tRNA-binding site [nucleotide binding]; other site
440085004407	B3/4 domain; Region: B3_4; pfam03483
440085004408	tRNA synthetase B5 domain; Region: B5; smart00874
440085004409	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
440085004410	dimer interface [polypeptide binding]; other site
440085004411	motif 1; other site
440085004412	motif 3; other site
440085004413	motif 2; other site
440085004414	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
440085004415	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
440085004416	SEC-C motif; Region: SEC-C; pfam02810
440085004417	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
440085004418	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
440085004419	ATP binding site [chemical binding]; other site
440085004420	substrate interface [chemical binding]; other site
440085004421	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
440085004422	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
440085004423	metal binding site [ion binding]; metal-binding site
440085004424	dimer interface [polypeptide binding]; other site
440085004425	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
440085004426	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
440085004427	dimerization interface 3.5A [polypeptide binding]; other site
440085004428	active site
440085004429	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
440085004430	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
440085004431	putative active site [active]
440085004432	substrate binding site [chemical binding]; other site
440085004433	putative cosubstrate binding site; other site
440085004434	catalytic site [active]
440085004435	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
440085004436	substrate binding site [chemical binding]; other site
440085004437	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
440085004438	active site
440085004439	catalytic residues [active]
440085004440	metal binding site [ion binding]; metal-binding site
440085004441	recombination protein RecR; Reviewed; Region: recR; PRK00076
440085004442	RecR protein; Region: RecR; pfam02132
440085004443	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
440085004444	putative active site [active]
440085004445	putative metal-binding site [ion binding]; other site
440085004446	tetramer interface [polypeptide binding]; other site
440085004447	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
440085004448	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
440085004449	active site
440085004450	substrate-binding site [chemical binding]; other site
440085004451	metal-binding site [ion binding]
440085004452	ATP binding site [chemical binding]; other site
440085004453	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
440085004454	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085004455	FeS/SAM binding site; other site
440085004456	shikimate kinase; Provisional; Region: PRK13946
440085004457	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
440085004458	ADP binding site [chemical binding]; other site
440085004459	magnesium binding site [ion binding]; other site
440085004460	putative shikimate binding site; other site
440085004461	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
440085004462	active site
440085004463	dimer interface [polypeptide binding]; other site
440085004464	metal binding site [ion binding]; metal-binding site
440085004465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085004466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085004467	malate dehydrogenase; Reviewed; Region: PRK06223
440085004468	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
440085004469	NAD(P) binding site [chemical binding]; other site
440085004470	dimer interface [polypeptide binding]; other site
440085004471	tetramer (dimer of dimers) interface [polypeptide binding]; other site
440085004472	substrate binding site [chemical binding]; other site
440085004473	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
440085004474	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
440085004475	CoA-ligase; Region: Ligase_CoA; pfam00549
440085004476	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
440085004477	CoA binding domain; Region: CoA_binding; smart00881
440085004478	CoA-ligase; Region: Ligase_CoA; pfam00549
440085004479	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
440085004480	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
440085004481	TPP-binding site [chemical binding]; other site
440085004482	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
440085004483	dimer interface [polypeptide binding]; other site
440085004484	PYR/PP interface [polypeptide binding]; other site
440085004485	TPP binding site [chemical binding]; other site
440085004486	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
440085004487	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
440085004488	E3 interaction surface; other site
440085004489	lipoyl attachment site [posttranslational modification]; other site
440085004490	e3 binding domain; Region: E3_binding; pfam02817
440085004491	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
440085004492	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
440085004493	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
440085004494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085004495	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
440085004496	histidine kinase; Provisional; Region: PRK13557
440085004497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085004498	putative active site [active]
440085004499	heme pocket [chemical binding]; other site
440085004500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085004501	dimer interface [polypeptide binding]; other site
440085004502	phosphorylation site [posttranslational modification]
440085004503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085004504	ATP binding site [chemical binding]; other site
440085004505	Mg2+ binding site [ion binding]; other site
440085004506	G-X-G motif; other site
440085004507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004508	active site
440085004509	phosphorylation site [posttranslational modification]
440085004510	intermolecular recognition site; other site
440085004511	dimerization interface [polypeptide binding]; other site
440085004512	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
440085004513	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
440085004514	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
440085004515	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
440085004516	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
440085004517	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
440085004518	hydroxyglutarate oxidase; Provisional; Region: PRK11728
440085004519	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085004520	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
440085004521	conserved cys residue [active]
440085004522	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
440085004523	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
440085004524	active site
440085004525	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
440085004526	domain_subunit interface; other site
440085004527	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
440085004528	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
440085004529	active site
440085004530	FMN binding site [chemical binding]; other site
440085004531	substrate binding site [chemical binding]; other site
440085004532	3Fe-4S cluster binding site [ion binding]; other site
440085004533	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
440085004534	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
440085004535	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
440085004536	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
440085004537	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
440085004538	active site
440085004539	metal binding site [ion binding]; metal-binding site
440085004540	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085004541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085004542	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085004543	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
440085004544	Virulence factor SrfB; Region: SrfB; pfam07520
440085004545	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
440085004546	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085004547	Sporulation related domain; Region: SPOR; cl10051
440085004548	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
440085004549	amidase catalytic site [active]
440085004550	Zn binding residues [ion binding]; other site
440085004551	substrate binding site [chemical binding]; other site
440085004552	hypothetical protein; Provisional; Region: PRK14709
440085004553	D5 N terminal like; Region: D5_N; smart00885
440085004554	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085004555	active site
440085004556	DNA binding site [nucleotide binding]
440085004557	Int/Topo IB signature motif; other site
440085004558	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085004559	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085004560	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
440085004561	putative heme binding site [chemical binding]; other site
440085004562	putative substrate binding site [chemical binding]; other site
440085004563	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
440085004564	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085004565	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085004566	heme binding site [chemical binding]; other site
440085004567	substrate binding site [chemical binding]; other site
440085004568	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085004569	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
440085004570	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085004571	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
440085004572	Walker A/P-loop; other site
440085004573	ATP binding site [chemical binding]; other site
440085004574	Q-loop/lid; other site
440085004575	ABC transporter signature motif; other site
440085004576	Walker B; other site
440085004577	D-loop; other site
440085004578	H-loop/switch region; other site
440085004579	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085004580	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
440085004581	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085004582	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085004583	Predicted transcriptional regulator [Transcription]; Region: COG2345
440085004584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
440085004585	Histidine kinase; Region: HisKA_3; pfam07730
440085004586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085004587	ATP binding site [chemical binding]; other site
440085004588	Mg2+ binding site [ion binding]; other site
440085004589	G-X-G motif; other site
440085004590	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085004591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004592	active site
440085004593	phosphorylation site [posttranslational modification]
440085004594	intermolecular recognition site; other site
440085004595	dimerization interface [polypeptide binding]; other site
440085004596	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085004597	DNA binding residues [nucleotide binding]
440085004598	dimerization interface [polypeptide binding]; other site
440085004599	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085004600	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
440085004601	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085004602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085004603	S-adenosylmethionine binding site [chemical binding]; other site
440085004604	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085004605	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004606	dimerization interface [polypeptide binding]; other site
440085004607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004608	dimerization interface [polypeptide binding]; other site
440085004609	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004610	dimerization interface [polypeptide binding]; other site
440085004611	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085004612	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004613	dimerization interface [polypeptide binding]; other site
440085004614	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004615	dimerization interface [polypeptide binding]; other site
440085004616	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004617	dimerization interface [polypeptide binding]; other site
440085004618	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004619	dimerization interface [polypeptide binding]; other site
440085004620	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085004621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004622	dimerization interface [polypeptide binding]; other site
440085004623	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085004624	dimerization interface [polypeptide binding]; other site
440085004625	GAF domain; Region: GAF_2; pfam13185
440085004626	GAF domain; Region: GAF_3; pfam13492
440085004627	pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696
440085004628	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085004629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085004630	dimer interface [polypeptide binding]; other site
440085004631	phosphorylation site [posttranslational modification]
440085004632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085004633	ATP binding site [chemical binding]; other site
440085004634	Mg2+ binding site [ion binding]; other site
440085004635	G-X-G motif; other site
440085004636	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004638	active site
440085004639	phosphorylation site [posttranslational modification]
440085004640	intermolecular recognition site; other site
440085004641	dimerization interface [polypeptide binding]; other site
440085004642	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004644	active site
440085004645	phosphorylation site [posttranslational modification]
440085004646	intermolecular recognition site; other site
440085004647	dimerization interface [polypeptide binding]; other site
440085004648	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004650	active site
440085004651	phosphorylation site [posttranslational modification]
440085004652	intermolecular recognition site; other site
440085004653	dimerization interface [polypeptide binding]; other site
440085004654	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004656	active site
440085004657	phosphorylation site [posttranslational modification]
440085004658	intermolecular recognition site; other site
440085004659	dimerization interface [polypeptide binding]; other site
440085004660	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085004661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085004662	putative active site [active]
440085004663	heme pocket [chemical binding]; other site
440085004664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085004665	dimer interface [polypeptide binding]; other site
440085004666	phosphorylation site [posttranslational modification]
440085004667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085004668	ATP binding site [chemical binding]; other site
440085004669	Mg2+ binding site [ion binding]; other site
440085004670	G-X-G motif; other site
440085004671	Response regulator receiver domain; Region: Response_reg; pfam00072
440085004672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085004673	active site
440085004674	phosphorylation site [posttranslational modification]
440085004675	intermolecular recognition site; other site
440085004676	dimerization interface [polypeptide binding]; other site
440085004677	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
440085004678	NmrA-like family; Region: NmrA; pfam05368
440085004679	NADP binding site [chemical binding]; other site
440085004680	active site
440085004681	regulatory binding site [polypeptide binding]; other site
440085004682	LysR family transcriptional regulator; Provisional; Region: PRK14997
440085004683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004684	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085004685	putative effector binding pocket; other site
440085004686	dimerization interface [polypeptide binding]; other site
440085004687	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
440085004688	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
440085004689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085004690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004691	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085004692	dimerization interface [polypeptide binding]; other site
440085004693	Isochorismatase family; Region: Isochorismatase; pfam00857
440085004694	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
440085004695	catalytic triad [active]
440085004696	dimer interface [polypeptide binding]; other site
440085004697	conserved cis-peptide bond; other site
440085004698	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
440085004699	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
440085004700	putative NAD(P) binding site [chemical binding]; other site
440085004701	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
440085004702	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004703	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
440085004704	dimerization interface [polypeptide binding]; other site
440085004705	substrate binding pocket [chemical binding]; other site
440085004706	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
440085004707	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085004708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085004709	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085004710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085004712	dimerization interface [polypeptide binding]; other site
440085004713	Uncharacterized conserved protein [Function unknown]; Region: COG1359
440085004714	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
440085004715	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
440085004716	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
440085004717	putative NAD(P) binding site [chemical binding]; other site
440085004718	dimer interface [polypeptide binding]; other site
440085004719	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
440085004720	EamA-like transporter family; Region: EamA; pfam00892
440085004721	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085004722	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085004723	metal binding site [ion binding]; metal-binding site
440085004724	active site
440085004725	I-site; other site
440085004726	Amidase; Region: Amidase; cl11426
440085004727	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
440085004728	HYR domain; Region: HYR; pfam02494
440085004729	HYR domain; Region: HYR; pfam02494
440085004730	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
440085004731	xanthine permease; Region: pbuX; TIGR03173
440085004732	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
440085004733	amidase; Provisional; Region: PRK09201
440085004734	Amidase; Region: Amidase; pfam01425
440085004735	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
440085004736	Isochorismatase family; Region: Isochorismatase; pfam00857
440085004737	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
440085004738	catalytic triad [active]
440085004739	conserved cis-peptide bond; other site
440085004740	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
440085004741	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
440085004742	active site
440085004743	putative substrate binding pocket [chemical binding]; other site
440085004744	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
440085004745	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
440085004746	Walker A/P-loop; other site
440085004747	ATP binding site [chemical binding]; other site
440085004748	Q-loop/lid; other site
440085004749	ABC transporter signature motif; other site
440085004750	Walker B; other site
440085004751	D-loop; other site
440085004752	H-loop/switch region; other site
440085004753	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
440085004754	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085004755	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
440085004756	TM-ABC transporter signature motif; other site
440085004757	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
440085004758	TM-ABC transporter signature motif; other site
440085004759	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
440085004760	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
440085004761	putative ligand binding site [chemical binding]; other site
440085004762	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
440085004763	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085004764	TM-ABC transporter signature motif; other site
440085004765	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085004766	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
440085004767	TM-ABC transporter signature motif; other site
440085004768	formamidase; Provisional; Region: amiF; PRK13287
440085004769	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
440085004770	multimer interface [polypeptide binding]; other site
440085004771	active site
440085004772	catalytic triad [active]
440085004773	dimer interface [polypeptide binding]; other site
440085004774	Isochorismatase family; Region: Isochorismatase; pfam00857
440085004775	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
440085004776	catalytic triad [active]
440085004777	conserved cis-peptide bond; other site
440085004778	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
440085004779	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
440085004780	Walker A/P-loop; other site
440085004781	ATP binding site [chemical binding]; other site
440085004782	Q-loop/lid; other site
440085004783	ABC transporter signature motif; other site
440085004784	Walker B; other site
440085004785	D-loop; other site
440085004786	H-loop/switch region; other site
440085004787	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
440085004788	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
440085004789	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
440085004790	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
440085004791	putative ligand binding site [chemical binding]; other site
440085004792	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
440085004793	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
440085004794	Creatinine amidohydrolase; Region: Creatininase; pfam02633
440085004795	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
440085004796	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085004797	acyl-activating enzyme (AAE) consensus motif; other site
440085004798	AMP binding site [chemical binding]; other site
440085004799	active site
440085004800	CoA binding site [chemical binding]; other site
440085004801	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
440085004802	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
440085004803	FAD binding domain; Region: FAD_binding_4; pfam01565
440085004804	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
440085004805	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
440085004806	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
440085004807	NMT1/THI5 like; Region: NMT1; pfam09084
440085004808	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
440085004809	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085004810	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
440085004811	iron-sulfur cluster [ion binding]; other site
440085004812	[2Fe-2S] cluster binding site [ion binding]; other site
440085004813	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
440085004814	hydrophobic ligand binding site; other site
440085004815	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085004816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085004817	dimer interface [polypeptide binding]; other site
440085004818	conserved gate region; other site
440085004819	putative PBP binding loops; other site
440085004820	ABC-ATPase subunit interface; other site
440085004821	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085004822	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085004823	Walker A/P-loop; other site
440085004824	ATP binding site [chemical binding]; other site
440085004825	Q-loop/lid; other site
440085004826	ABC transporter signature motif; other site
440085004827	Walker B; other site
440085004828	D-loop; other site
440085004829	H-loop/switch region; other site
440085004830	NMT1/THI5 like; Region: NMT1; pfam09084
440085004831	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085004832	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004833	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085004834	dimerization interface [polypeptide binding]; other site
440085004835	cytosine deaminase-like protein; Validated; Region: PRK07583
440085004836	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
440085004837	active site
440085004838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085004839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004840	LysR substrate binding domain; Region: LysR_substrate; pfam03466
440085004841	dimerization interface [polypeptide binding]; other site
440085004842	guanine deaminase; Provisional; Region: PRK09228
440085004843	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
440085004844	active site
440085004845	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
440085004846	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085004847	catalytic loop [active]
440085004848	iron binding site [ion binding]; other site
440085004849	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085004850	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085004851	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085004852	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085004853	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
440085004854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
440085004855	NMT1/THI5 like; Region: NMT1; pfam09084
440085004856	substrate binding pocket [chemical binding]; other site
440085004857	membrane-bound complex binding site; other site
440085004858	hinge residues; other site
440085004859	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085004860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085004861	dimer interface [polypeptide binding]; other site
440085004862	conserved gate region; other site
440085004863	putative PBP binding loops; other site
440085004864	ABC-ATPase subunit interface; other site
440085004865	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085004866	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
440085004867	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085004868	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
440085004869	Walker A/P-loop; other site
440085004870	ATP binding site [chemical binding]; other site
440085004871	Q-loop/lid; other site
440085004872	ABC transporter signature motif; other site
440085004873	Walker B; other site
440085004874	D-loop; other site
440085004875	H-loop/switch region; other site
440085004876	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
440085004877	pyrimidine utilization protein D; Region: RutD; TIGR03611
440085004878	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085004879	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
440085004880	homotrimer interaction site [polypeptide binding]; other site
440085004881	putative active site [active]
440085004882	Isochorismatase family; Region: Isochorismatase; pfam00857
440085004883	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
440085004884	catalytic triad [active]
440085004885	conserved cis-peptide bond; other site
440085004886	pyrimidine utilization protein A; Region: RutA; TIGR03612
440085004887	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
440085004888	active site
440085004889	dimer interface [polypeptide binding]; other site
440085004890	non-prolyl cis peptide bond; other site
440085004891	insertion regions; other site
440085004892	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
440085004893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085004894	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
440085004895	ureidoglycolate hydrolase; Provisional; Region: PRK03606
440085004896	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
440085004897	hypothetical protein; Provisional; Region: PRK11171
440085004898	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
440085004899	Cupin domain; Region: Cupin_2; pfam07883
440085004900	Predicted membrane protein [Function unknown]; Region: COG3748
440085004901	Protein of unknown function (DUF989); Region: DUF989; pfam06181
440085004902	Cytochrome c; Region: Cytochrom_C; pfam00034
440085004903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085004904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004905	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085004906	putative effector binding pocket; other site
440085004907	dimerization interface [polypeptide binding]; other site
440085004908	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
440085004909	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
440085004910	active site
440085004911	catalytic site [active]
440085004912	tetramer interface [polypeptide binding]; other site
440085004913	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
440085004914	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
440085004915	active site
440085004916	homotetramer interface [polypeptide binding]; other site
440085004917	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
440085004918	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085004919	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
440085004920	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
440085004921	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
440085004922	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085004923	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085004924	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085004925	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
440085004926	hydrophobic ligand binding site; other site
440085004927	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
440085004928	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
440085004929	active site
440085004930	putative substrate binding pocket [chemical binding]; other site
440085004931	choline dehydrogenase; Validated; Region: PRK02106
440085004932	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
440085004933	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
440085004934	TPP-binding site [chemical binding]; other site
440085004935	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085004936	PYR/PP interface [polypeptide binding]; other site
440085004937	dimer interface [polypeptide binding]; other site
440085004938	TPP binding site [chemical binding]; other site
440085004939	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085004940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085004941	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085004942	dimerization interface [polypeptide binding]; other site
440085004943	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085004944	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085004945	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
440085004946	dimer interface [polypeptide binding]; other site
440085004947	N-terminal domain interface [polypeptide binding]; other site
440085004948	substrate binding pocket (H-site) [chemical binding]; other site
440085004949	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085004950	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
440085004951	[2Fe-2S] cluster binding site [ion binding]; other site
440085004952	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
440085004953	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
440085004954	putative ligand binding site [chemical binding]; other site
440085004955	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
440085004956	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
440085004957	Walker A/P-loop; other site
440085004958	ATP binding site [chemical binding]; other site
440085004959	Q-loop/lid; other site
440085004960	ABC transporter signature motif; other site
440085004961	Walker B; other site
440085004962	D-loop; other site
440085004963	H-loop/switch region; other site
440085004964	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
440085004965	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085004966	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
440085004967	TM-ABC transporter signature motif; other site
440085004968	Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079
440085004969	TM-ABC transporter signature motif; other site
440085004970	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
440085004971	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
440085004972	active site
440085004973	putative substrate binding pocket [chemical binding]; other site
440085004974	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085004975	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
440085004976	hydrophobic ligand binding site; other site
440085004977	Protein of unknown function (DUF808); Region: DUF808; cl01002
440085004978	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085004979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085004980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085004981	metal binding site [ion binding]; metal-binding site
440085004982	active site
440085004983	I-site; other site
440085004984	OmpW family; Region: OmpW; cl17427
440085004985	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
440085004986	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
440085004987	Phosphotransferase enzyme family; Region: APH; pfam01636
440085004988	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
440085004989	active site
440085004990	substrate binding site [chemical binding]; other site
440085004991	ATP binding site [chemical binding]; other site
440085004992	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
440085004993	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
440085004994	putative acyl-acceptor binding pocket; other site
440085004995	Protein of unknown function (DUF497); Region: DUF497; pfam04365
440085004996	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
440085004997	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085004998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085004999	S-adenosylmethionine binding site [chemical binding]; other site
440085005000	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
440085005001	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
440085005002	methionine sulfoxide reductase B; Provisional; Region: PRK00222
440085005003	SelR domain; Region: SelR; pfam01641
440085005004	methionine sulfoxide reductase A; Provisional; Region: PRK13014
440085005005	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
440085005006	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
440085005007	heme binding site [chemical binding]; other site
440085005008	ferroxidase pore; other site
440085005009	ferroxidase diiron center [ion binding]; other site
440085005010	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
440085005011	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085005012	Ligand Binding Site [chemical binding]; other site
440085005013	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
440085005014	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
440085005015	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
440085005016	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
440085005017	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
440085005018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085005019	FeS/SAM binding site; other site
440085005020	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
440085005021	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
440085005022	active site
440085005023	oligomerization interface [polypeptide binding]; other site
440085005024	metal binding site [ion binding]; metal-binding site
440085005025	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
440085005026	catalytic residues [active]
440085005027	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
440085005028	active site residue [active]
440085005029	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
440085005030	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
440085005031	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085005032	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085005033	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085005034	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
440085005035	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
440085005036	P-loop, Walker A motif; other site
440085005037	Base recognition motif; other site
440085005038	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
440085005039	GAF domain; Region: GAF_2; pfam13185
440085005040	GAF domain; Region: GAF; pfam01590
440085005041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005042	putative active site [active]
440085005043	PAS fold; Region: PAS_3; pfam08447
440085005044	heme pocket [chemical binding]; other site
440085005045	PAS domain S-box; Region: sensory_box; TIGR00229
440085005046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005047	putative active site [active]
440085005048	heme pocket [chemical binding]; other site
440085005049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005050	PAS fold; Region: PAS_3; pfam08447
440085005051	putative active site [active]
440085005052	heme pocket [chemical binding]; other site
440085005053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085005054	dimer interface [polypeptide binding]; other site
440085005055	phosphorylation site [posttranslational modification]
440085005056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085005057	ATP binding site [chemical binding]; other site
440085005058	Mg2+ binding site [ion binding]; other site
440085005059	G-X-G motif; other site
440085005060	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085005061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005062	active site
440085005063	phosphorylation site [posttranslational modification]
440085005064	intermolecular recognition site; other site
440085005065	dimerization interface [polypeptide binding]; other site
440085005066	YcjX-like family, DUF463; Region: DUF463; pfam04317
440085005067	hypothetical protein; Provisional; Region: PRK05415
440085005068	Domain of unknown function (DUF697); Region: DUF697; cl12064
440085005069	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
440085005070	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085005071	diaminopimelate decarboxylase; Region: lysA; TIGR01048
440085005072	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
440085005073	active site
440085005074	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
440085005075	substrate binding site [chemical binding]; other site
440085005076	catalytic residues [active]
440085005077	dimer interface [polypeptide binding]; other site
440085005078	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
440085005079	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
440085005080	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
440085005081	RNA/DNA hybrid binding site [nucleotide binding]; other site
440085005082	active site
440085005083	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
440085005084	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085005085	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
440085005086	putative active site [active]
440085005087	putative metal binding site [ion binding]; other site
440085005088	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
440085005089	homodimer interface [polypeptide binding]; other site
440085005090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085005091	catalytic residue [active]
440085005092	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
440085005093	glycerate dehydrogenase; Provisional; Region: PRK06487
440085005094	putative ligand binding site [chemical binding]; other site
440085005095	putative NAD binding site [chemical binding]; other site
440085005096	catalytic site [active]
440085005097	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
440085005098	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
440085005099	NADP binding site [chemical binding]; other site
440085005100	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
440085005101	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
440085005102	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
440085005103	CoA-ligase; Region: Ligase_CoA; pfam00549
440085005104	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
440085005105	CoA binding domain; Region: CoA_binding; pfam02629
440085005106	CoA-ligase; Region: Ligase_CoA; pfam00549
440085005107	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
440085005108	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
440085005109	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
440085005110	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
440085005111	Dienelactone hydrolase family; Region: DLH; pfam01738
440085005112	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
440085005113	aromatic arch; other site
440085005114	DCoH dimer interaction site [polypeptide binding]; other site
440085005115	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
440085005116	DCoH tetramer interaction site [polypeptide binding]; other site
440085005117	substrate binding site [chemical binding]; other site
440085005118	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085005119	substrate binding pocket [chemical binding]; other site
440085005120	membrane-bound complex binding site; other site
440085005121	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085005122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085005123	dimer interface [polypeptide binding]; other site
440085005124	conserved gate region; other site
440085005125	putative PBP binding loops; other site
440085005126	ABC-ATPase subunit interface; other site
440085005127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085005128	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
440085005129	Walker A/P-loop; other site
440085005130	ATP binding site [chemical binding]; other site
440085005131	Q-loop/lid; other site
440085005132	ABC transporter signature motif; other site
440085005133	Walker B; other site
440085005134	D-loop; other site
440085005135	H-loop/switch region; other site
440085005136	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
440085005137	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
440085005138	Trp docking motif [polypeptide binding]; other site
440085005139	dimer interface [polypeptide binding]; other site
440085005140	active site
440085005141	small subunit binding site [polypeptide binding]; other site
440085005142	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
440085005143	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
440085005144	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085005145	substrate binding pocket [chemical binding]; other site
440085005146	membrane-bound complex binding site; other site
440085005147	hinge residues; other site
440085005148	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
440085005149	catalytic center binding site [active]
440085005150	ATP binding site [chemical binding]; other site
440085005151	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
440085005152	homooctamer interface [polypeptide binding]; other site
440085005153	active site
440085005154	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
440085005155	dihydropteroate synthase; Region: DHPS; TIGR01496
440085005156	substrate binding pocket [chemical binding]; other site
440085005157	dimer interface [polypeptide binding]; other site
440085005158	inhibitor binding site; inhibition site
440085005159	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
440085005160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085005161	FeS/SAM binding site; other site
440085005162	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
440085005163	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
440085005164	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
440085005165	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
440085005166	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
440085005167	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085005168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005169	active site
440085005170	phosphorylation site [posttranslational modification]
440085005171	intermolecular recognition site; other site
440085005172	dimerization interface [polypeptide binding]; other site
440085005173	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085005174	DNA binding site [nucleotide binding]
440085005175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085005176	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085005177	dimer interface [polypeptide binding]; other site
440085005178	phosphorylation site [posttranslational modification]
440085005179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085005180	ATP binding site [chemical binding]; other site
440085005181	Mg2+ binding site [ion binding]; other site
440085005182	G-X-G motif; other site
440085005183	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
440085005184	domain_subunit interface; other site
440085005185	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
440085005186	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
440085005187	FTR, proximal lobe; Region: FTR_C; pfam02741
440085005188	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
440085005189	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
440085005190	active site
440085005191	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
440085005192	molybdopterin cofactor binding site; other site
440085005193	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
440085005194	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
440085005195	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
440085005196	NADP binding site [chemical binding]; other site
440085005197	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085005198	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
440085005199	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
440085005200	trimer interface I [polypeptide binding]; other site
440085005201	putative substrate binding pocket [chemical binding]; other site
440085005202	trimer interface II [polypeptide binding]; other site
440085005203	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
440085005204	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085005205	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
440085005206	formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126
440085005207	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
440085005208	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
440085005209	active site
440085005210	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
440085005211	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
440085005212	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005213	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005214	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005215	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005216	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
440085005217	putative hydrophobic ligand binding site [chemical binding]; other site
440085005218	protein interface [polypeptide binding]; other site
440085005219	gate; other site
440085005220	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
440085005221	putative hydrophobic ligand binding site [chemical binding]; other site
440085005222	protein interface [polypeptide binding]; other site
440085005223	gate; other site
440085005224	Protein of unknown function (DUF447); Region: DUF447; pfam04289
440085005225	dihydropteroate synthase-related protein; Region: TIGR00284
440085005226	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
440085005227	substrate binding pocket [chemical binding]; other site
440085005228	dimer interface [polypeptide binding]; other site
440085005229	inhibitor binding site; inhibition site
440085005230	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
440085005231	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
440085005232	nucleotide binding site [chemical binding]; other site
440085005233	substrate binding site [chemical binding]; other site
440085005234	hypothetical protein; Provisional; Region: PRK02227
440085005235	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
440085005236	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
440085005237	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085005238	ligand binding site [chemical binding]; other site
440085005239	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
440085005240	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005241	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005242	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005243	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085005244	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
440085005245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085005246	Walker A/P-loop; other site
440085005247	ATP binding site [chemical binding]; other site
440085005248	Q-loop/lid; other site
440085005249	ABC transporter signature motif; other site
440085005250	Walker B; other site
440085005251	D-loop; other site
440085005252	H-loop/switch region; other site
440085005253	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
440085005254	ABC-2 type transporter; Region: ABC2_membrane; cl17235
440085005255	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085005256	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085005257	EF-hand domain pair; Region: EF_hand_5; pfam13499
440085005258	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
440085005259	Ca2+ binding site [ion binding]; other site
440085005260	hypothetical protein; Validated; Region: PRK00068
440085005261	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
440085005262	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
440085005263	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085005264	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
440085005265	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
440085005266	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
440085005267	SLBB domain; Region: SLBB; pfam10531
440085005268	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
440085005269	Chain length determinant protein; Region: Wzz; pfam02706
440085005270	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
440085005271	hypothetical protein; Validated; Region: PRK00153
440085005272	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
440085005273	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
440085005274	active site
440085005275	DNA polymerase III subunit delta'; Validated; Region: PRK08485
440085005276	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
440085005277	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
440085005278	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
440085005279	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
440085005280	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
440085005281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085005282	Walker A motif; other site
440085005283	ATP binding site [chemical binding]; other site
440085005284	Walker B motif; other site
440085005285	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
440085005286	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085005287	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
440085005288	putative C-terminal domain interface [polypeptide binding]; other site
440085005289	putative GSH binding site (G-site) [chemical binding]; other site
440085005290	putative dimer interface [polypeptide binding]; other site
440085005291	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
440085005292	N-terminal domain interface [polypeptide binding]; other site
440085005293	Uncharacterized conserved protein [Function unknown]; Region: COG3287
440085005294	FIST N domain; Region: FIST; pfam08495
440085005295	FIST C domain; Region: FIST_C; pfam10442
440085005296	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085005297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085005298	dimer interface [polypeptide binding]; other site
440085005299	phosphorylation site [posttranslational modification]
440085005300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085005301	ATP binding site [chemical binding]; other site
440085005302	Mg2+ binding site [ion binding]; other site
440085005303	G-X-G motif; other site
440085005304	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085005305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005306	active site
440085005307	phosphorylation site [posttranslational modification]
440085005308	intermolecular recognition site; other site
440085005309	dimerization interface [polypeptide binding]; other site
440085005310	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
440085005311	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
440085005312	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
440085005313	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
440085005314	substrate binding pocket [chemical binding]; other site
440085005315	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085005316	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
440085005317	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085005318	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085005319	catalytic residue [active]
440085005320	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
440085005321	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
440085005322	putative [4Fe-4S] binding site [ion binding]; other site
440085005323	putative molybdopterin cofactor binding site [chemical binding]; other site
440085005324	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
440085005325	molybdopterin cofactor binding site; other site
440085005326	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
440085005327	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085005328	Walker A/P-loop; other site
440085005329	ATP binding site [chemical binding]; other site
440085005330	Q-loop/lid; other site
440085005331	ABC transporter signature motif; other site
440085005332	Walker B; other site
440085005333	D-loop; other site
440085005334	H-loop/switch region; other site
440085005335	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085005336	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085005337	Walker A/P-loop; other site
440085005338	ATP binding site [chemical binding]; other site
440085005339	Q-loop/lid; other site
440085005340	ABC transporter signature motif; other site
440085005341	Walker B; other site
440085005342	D-loop; other site
440085005343	H-loop/switch region; other site
440085005344	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085005345	phosphopentomutase; Provisional; Region: PRK05362
440085005346	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
440085005347	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
440085005348	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085005349	Walker A/P-loop; other site
440085005350	ATP binding site [chemical binding]; other site
440085005351	Q-loop/lid; other site
440085005352	ABC transporter signature motif; other site
440085005353	Walker B; other site
440085005354	D-loop; other site
440085005355	H-loop/switch region; other site
440085005356	ABC transporter; Region: ABC_tran_2; pfam12848
440085005357	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085005358	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
440085005359	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
440085005360	active site
440085005361	substrate binding site [chemical binding]; other site
440085005362	Mg2+ binding site [ion binding]; other site
440085005363	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
440085005364	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
440085005365	TPP-binding site; other site
440085005366	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
440085005367	PYR/PP interface [polypeptide binding]; other site
440085005368	dimer interface [polypeptide binding]; other site
440085005369	TPP binding site [chemical binding]; other site
440085005370	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
440085005371	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
440085005372	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
440085005373	putative NADP binding site [chemical binding]; other site
440085005374	putative substrate binding site [chemical binding]; other site
440085005375	active site
440085005376	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
440085005377	active site lid residues [active]
440085005378	substrate binding pocket [chemical binding]; other site
440085005379	catalytic residues [active]
440085005380	substrate-Mg2+ binding site; other site
440085005381	aspartate-rich region 1; other site
440085005382	aspartate-rich region 2; other site
440085005383	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
440085005384	active site lid residues [active]
440085005385	substrate binding pocket [chemical binding]; other site
440085005386	catalytic residues [active]
440085005387	substrate-Mg2+ binding site; other site
440085005388	aspartate-rich region 1; other site
440085005389	aspartate-rich region 2; other site
440085005390	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
440085005391	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
440085005392	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
440085005393	Active site cavity [active]
440085005394	catalytic acid [active]
440085005395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085005396	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
440085005397	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
440085005398	substrate-cofactor binding pocket; other site
440085005399	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085005400	catalytic residue [active]
440085005401	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
440085005402	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
440085005403	active site
440085005404	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
440085005405	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
440085005406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085005407	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
440085005408	Enoylreductase; Region: PKS_ER; smart00829
440085005409	NAD(P) binding site [chemical binding]; other site
440085005410	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
440085005411	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
440085005412	putative NADP binding site [chemical binding]; other site
440085005413	active site
440085005414	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
440085005415	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
440085005416	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
440085005417	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
440085005418	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
440085005419	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
440085005420	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
440085005421	Probable Catalytic site; other site
440085005422	metal-binding site
440085005423	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085005424	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085005425	Probable Catalytic site; other site
440085005426	metal-binding site
440085005427	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
440085005428	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085005429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085005430	putative substrate translocation pore; other site
440085005431	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
440085005432	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
440085005433	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
440085005434	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
440085005435	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
440085005436	Sel1-like repeats; Region: SEL1; smart00671
440085005437	Sel1-like repeats; Region: SEL1; smart00671
440085005438	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
440085005439	putative catalytic site [active]
440085005440	putative phosphate binding site [ion binding]; other site
440085005441	active site
440085005442	metal binding site A [ion binding]; metal-binding site
440085005443	DNA binding site [nucleotide binding]
440085005444	putative AP binding site [nucleotide binding]; other site
440085005445	putative metal binding site B [ion binding]; other site
440085005446	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
440085005447	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085005448	acyl-activating enzyme (AAE) consensus motif; other site
440085005449	AMP binding site [chemical binding]; other site
440085005450	active site
440085005451	CoA binding site [chemical binding]; other site
440085005452	Uncharacterized small protein [Function unknown]; Region: COG5570
440085005453	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
440085005454	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
440085005455	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
440085005456	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
440085005457	ATP-grasp domain; Region: ATP-grasp; pfam02222
440085005458	TPR repeat; Region: TPR_11; pfam13414
440085005459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085005460	binding surface
440085005461	TPR motif; other site
440085005462	TPR repeat; Region: TPR_11; pfam13414
440085005463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085005464	binding surface
440085005465	TPR motif; other site
440085005466	TPR repeat; Region: TPR_11; pfam13414
440085005467	Response regulator receiver domain; Region: Response_reg; pfam00072
440085005468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005469	active site
440085005470	phosphorylation site [posttranslational modification]
440085005471	intermolecular recognition site; other site
440085005472	dimerization interface [polypeptide binding]; other site
440085005473	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
440085005474	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
440085005475	putative active site [active]
440085005476	homoserine dehydrogenase; Provisional; Region: PRK06349
440085005477	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
440085005478	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
440085005479	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
440085005480	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
440085005481	Nucleoside recognition; Region: Gate; pfam07670
440085005482	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
440085005483	Predicted methyltransferase [General function prediction only]; Region: COG3897
440085005484	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
440085005485	putative ADP-binding pocket [chemical binding]; other site
440085005486	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085005487	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
440085005488	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
440085005489	active site
440085005490	DNA binding site [nucleotide binding]
440085005491	Int/Topo IB signature motif; other site
440085005492	catalytic residues [active]
440085005493	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085005494	dimer interface [polypeptide binding]; other site
440085005495	putative CheW interface [polypeptide binding]; other site
440085005496	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
440085005497	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085005498	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085005499	DNA binding residues [nucleotide binding]
440085005500	dimerization interface [polypeptide binding]; other site
440085005501	Response regulator receiver domain; Region: Response_reg; pfam00072
440085005502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005503	active site
440085005504	phosphorylation site [posttranslational modification]
440085005505	intermolecular recognition site; other site
440085005506	dimerization interface [polypeptide binding]; other site
440085005507	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085005508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085005509	metal binding site [ion binding]; metal-binding site
440085005510	active site
440085005511	I-site; other site
440085005512	Iron permease FTR1 family; Region: FTR1; cl00475
440085005513	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
440085005514	Low molecular weight phosphatase family; Region: LMWPc; cd00115
440085005515	active site
440085005516	hypothetical protein; Provisional; Region: PRK02853
440085005517	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
440085005518	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
440085005519	NAD binding site [chemical binding]; other site
440085005520	dimerization interface [polypeptide binding]; other site
440085005521	product binding site; other site
440085005522	substrate binding site [chemical binding]; other site
440085005523	zinc binding site [ion binding]; other site
440085005524	catalytic residues [active]
440085005525	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
440085005526	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
440085005527	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
440085005528	hinge; other site
440085005529	active site
440085005530	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
440085005531	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
440085005532	substrate-cofactor binding pocket; other site
440085005533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085005534	catalytic residue [active]
440085005535	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
440085005536	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
440085005537	PhnA protein; Region: PhnA; pfam03831
440085005538	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
440085005539	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
440085005540	hypothetical protein; Provisional; Region: PRK11820
440085005541	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
440085005542	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
440085005543	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
440085005544	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
440085005545	catalytic site [active]
440085005546	G-X2-G-X-G-K; other site
440085005547	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
440085005548	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085005549	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
440085005550	Walker A/P-loop; other site
440085005551	ATP binding site [chemical binding]; other site
440085005552	Q-loop/lid; other site
440085005553	ABC transporter signature motif; other site
440085005554	Walker B; other site
440085005555	D-loop; other site
440085005556	H-loop/switch region; other site
440085005557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085005558	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085005559	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
440085005560	putative FMN binding site [chemical binding]; other site
440085005561	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
440085005562	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085005563	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085005564	N-terminal plug; other site
440085005565	ligand-binding site [chemical binding]; other site
440085005566	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
440085005567	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
440085005568	active site
440085005569	intersubunit interface [polypeptide binding]; other site
440085005570	catalytic residue [active]
440085005571	phosphogluconate dehydratase; Validated; Region: PRK09054
440085005572	6-phosphogluconate dehydratase; Region: edd; TIGR01196
440085005573	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
440085005574	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
440085005575	dimerization interface [polypeptide binding]; other site
440085005576	domain crossover interface; other site
440085005577	redox-dependent activation switch; other site
440085005578	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
440085005579	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
440085005580	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
440085005581	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
440085005582	active site
440085005583	multimer interface [polypeptide binding]; other site
440085005584	Peptidase family M48; Region: Peptidase_M48; cl12018
440085005585	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
440085005586	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
440085005587	Protein of unknown function (DUF466); Region: DUF466; pfam04328
440085005588	carbon starvation protein A; Provisional; Region: PRK15015
440085005589	Carbon starvation protein CstA; Region: CstA; pfam02554
440085005590	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
440085005591	Repair protein; Region: Repair_PSII; cl01535
440085005592	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
440085005593	Repair protein; Region: Repair_PSII; pfam04536
440085005594	LemA family; Region: LemA; pfam04011
440085005595	Rdx family; Region: Rdx; cl01407
440085005596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005597	PAS domain; Region: PAS_9; pfam13426
440085005598	putative active site [active]
440085005599	heme pocket [chemical binding]; other site
440085005600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085005601	HWE histidine kinase; Region: HWE_HK; pfam07536
440085005602	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085005603	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085005604	active site
440085005605	catalytic tetrad [active]
440085005606	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085005607	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085005608	ligand binding site [chemical binding]; other site
440085005609	flexible hinge region; other site
440085005610	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085005611	putative switch regulator; other site
440085005612	non-specific DNA interactions [nucleotide binding]; other site
440085005613	DNA binding site [nucleotide binding]
440085005614	sequence specific DNA binding site [nucleotide binding]; other site
440085005615	putative cAMP binding site [chemical binding]; other site
440085005616	glycogen synthase; Provisional; Region: glgA; PRK00654
440085005617	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
440085005618	ADP-binding pocket [chemical binding]; other site
440085005619	homodimer interface [polypeptide binding]; other site
440085005620	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
440085005621	active site
440085005622	catalytic site [active]
440085005623	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
440085005624	homodimer interface [polypeptide binding]; other site
440085005625	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
440085005626	active site pocket [active]
440085005627	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
440085005628	FAD binding pocket [chemical binding]; other site
440085005629	FAD binding motif [chemical binding]; other site
440085005630	phosphate binding motif [ion binding]; other site
440085005631	beta-alpha-beta structure motif; other site
440085005632	NAD binding pocket [chemical binding]; other site
440085005633	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
440085005634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005635	PAS fold; Region: PAS_3; pfam08447
440085005636	putative active site [active]
440085005637	heme pocket [chemical binding]; other site
440085005638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085005639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085005640	metal binding site [ion binding]; metal-binding site
440085005641	active site
440085005642	I-site; other site
440085005643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085005644	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
440085005645	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
440085005646	Mg++ binding site [ion binding]; other site
440085005647	putative catalytic motif [active]
440085005648	putative substrate binding site [chemical binding]; other site
440085005649	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085005650	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
440085005651	NAD(P) binding site [chemical binding]; other site
440085005652	active site
440085005653	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
440085005654	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085005655	Predicted transcriptional regulators [Transcription]; Region: COG1733
440085005656	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
440085005657	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
440085005658	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
440085005659	NAD(P) binding site [chemical binding]; other site
440085005660	homodimer interface [polypeptide binding]; other site
440085005661	substrate binding site [chemical binding]; other site
440085005662	active site
440085005663	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
440085005664	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
440085005665	putative active site [active]
440085005666	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
440085005667	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
440085005668	Predicted acetyltransferase [General function prediction only]; Region: COG3153
440085005669	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
440085005670	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
440085005671	dimer interface [polypeptide binding]; other site
440085005672	active site
440085005673	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
440085005674	catalytic residues [active]
440085005675	substrate binding site [chemical binding]; other site
440085005676	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
440085005677	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
440085005678	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
440085005679	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
440085005680	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
440085005681	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
440085005682	FMN binding site [chemical binding]; other site
440085005683	active site
440085005684	substrate binding site [chemical binding]; other site
440085005685	catalytic residue [active]
440085005686	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
440085005687	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085005688	motif II; other site
440085005689	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
440085005690	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
440085005691	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
440085005692	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
440085005693	putative phosphate acyltransferase; Provisional; Region: PRK05331
440085005694	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
440085005695	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
440085005696	dimer interface [polypeptide binding]; other site
440085005697	active site
440085005698	CoA binding pocket [chemical binding]; other site
440085005699	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
440085005700	IHF dimer interface [polypeptide binding]; other site
440085005701	IHF - DNA interface [nucleotide binding]; other site
440085005702	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
440085005703	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
440085005704	DNA binding residues [nucleotide binding]
440085005705	PrkA family serine protein kinase; Provisional; Region: PRK15455
440085005706	AAA ATPase domain; Region: AAA_16; pfam13191
440085005707	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
440085005708	hypothetical protein; Provisional; Region: PRK05325
440085005709	SpoVR family protein; Provisional; Region: PRK11767
440085005710	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
440085005711	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
440085005712	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
440085005713	active site
440085005714	substrate binding site [chemical binding]; other site
440085005715	cosubstrate binding site; other site
440085005716	catalytic site [active]
440085005717	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
440085005718	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
440085005719	dimerization interface [polypeptide binding]; other site
440085005720	putative ATP binding site [chemical binding]; other site
440085005721	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085005722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085005723	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
440085005724	polyphosphate kinase; Provisional; Region: PRK05443
440085005725	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
440085005726	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
440085005727	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
440085005728	putative domain interface [polypeptide binding]; other site
440085005729	putative active site [active]
440085005730	catalytic site [active]
440085005731	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
440085005732	putative domain interface [polypeptide binding]; other site
440085005733	putative active site [active]
440085005734	catalytic site [active]
440085005735	exopolyphosphatase; Region: exo_poly_only; TIGR03706
440085005736	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
440085005737	aspartate aminotransferase; Provisional; Region: PRK05764
440085005738	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085005739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085005740	homodimer interface [polypeptide binding]; other site
440085005741	catalytic residue [active]
440085005742	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
440085005743	Coenzyme A transferase; Region: CoA_trans; smart00882
440085005744	Coenzyme A transferase; Region: CoA_trans; cl17247
440085005745	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085005746	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085005747	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085005748	dimerization interface [polypeptide binding]; other site
440085005749	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085005750	dimer interface [polypeptide binding]; other site
440085005751	putative CheW interface [polypeptide binding]; other site
440085005752	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
440085005753	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
440085005754	rRNA interaction site [nucleotide binding]; other site
440085005755	S8 interaction site; other site
440085005756	putative laminin-1 binding site; other site
440085005757	Uncharacterized conserved protein [Function unknown]; Region: COG3743
440085005758	elongation factor Ts; Provisional; Region: tsf; PRK09377
440085005759	UBA/TS-N domain; Region: UBA; pfam00627
440085005760	Elongation factor TS; Region: EF_TS; pfam00889
440085005761	Elongation factor TS; Region: EF_TS; pfam00889
440085005762	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
440085005763	putative nucleotide binding site [chemical binding]; other site
440085005764	uridine monophosphate binding site [chemical binding]; other site
440085005765	homohexameric interface [polypeptide binding]; other site
440085005766	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
440085005767	dimer interface [polypeptide binding]; other site
440085005768	substrate binding site [chemical binding]; other site
440085005769	metal binding sites [ion binding]; metal-binding site
440085005770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085005771	Coenzyme A binding pocket [chemical binding]; other site
440085005772	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
440085005773	Putative phosphatase (DUF442); Region: DUF442; cl17385
440085005774	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
440085005775	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
440085005776	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
440085005777	trimer interface [polypeptide binding]; other site
440085005778	active site
440085005779	UDP-GlcNAc binding site [chemical binding]; other site
440085005780	lipid binding site [chemical binding]; lipid-binding site
440085005781	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
440085005782	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085005783	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085005784	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085005785	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085005786	Surface antigen; Region: Bac_surface_Ag; pfam01103
440085005787	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
440085005788	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
440085005789	active site
440085005790	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
440085005791	protein binding site [polypeptide binding]; other site
440085005792	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
440085005793	putative substrate binding region [chemical binding]; other site
440085005794	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
440085005795	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
440085005796	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
440085005797	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
440085005798	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
440085005799	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
440085005800	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
440085005801	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
440085005802	catalytic residue [active]
440085005803	putative FPP diphosphate  binding site; other site
440085005804	putative FPP binding hydrophobic cleft; other site
440085005805	dimer interface [polypeptide binding]; other site
440085005806	putative IPP diphosphate binding site; other site
440085005807	ribosome recycling factor; Reviewed; Region: frr; PRK00083
440085005808	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
440085005809	hinge region; other site
440085005810	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
440085005811	HPP family; Region: HPP; pfam04982
440085005812	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
440085005813	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
440085005814	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
440085005815	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
440085005816	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085005817	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
440085005818	dimerization interface [polypeptide binding]; other site
440085005819	substrate binding pocket [chemical binding]; other site
440085005820	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
440085005821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085005822	NAD(P) binding site [chemical binding]; other site
440085005823	active site
440085005824	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
440085005825	TPP-binding site [chemical binding]; other site
440085005826	dimer interface [polypeptide binding]; other site
440085005827	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
440085005828	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
440085005829	PYR/PP interface [polypeptide binding]; other site
440085005830	dimer interface [polypeptide binding]; other site
440085005831	TPP binding site [chemical binding]; other site
440085005832	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
440085005833	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
440085005834	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
440085005835	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
440085005836	DctM-like transporters; Region: DctM; pfam06808
440085005837	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
440085005838	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085005839	Calx-beta domain; Region: Calx-beta; cl02522
440085005840	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
440085005841	generic binding surface II; other site
440085005842	generic binding surface I; other site
440085005843	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
440085005844	putative active site [active]
440085005845	putative catalytic site [active]
440085005846	putative Mg binding site IVb [ion binding]; other site
440085005847	putative phosphate binding site [ion binding]; other site
440085005848	putative DNA binding site [nucleotide binding]; other site
440085005849	putative Mg binding site IVa [ion binding]; other site
440085005850	Bacterial Ig-like domain; Region: Big_5; pfam13205
440085005851	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085005852	active site
440085005853	metal binding site [ion binding]; metal-binding site
440085005854	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
440085005855	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
440085005856	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
440085005857	active site
440085005858	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
440085005859	catalytic triad [active]
440085005860	dimer interface [polypeptide binding]; other site
440085005861	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
440085005862	Nitrogen regulatory protein P-II; Region: P-II; smart00938
440085005863	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
440085005864	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
440085005865	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
440085005866	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
440085005867	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
440085005868	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
440085005869	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085005870	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085005871	PAS fold; Region: PAS_4; pfam08448
440085005872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005873	PAS fold; Region: PAS_3; pfam08447
440085005874	putative active site [active]
440085005875	heme pocket [chemical binding]; other site
440085005876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085005877	HWE histidine kinase; Region: HWE_HK; smart00911
440085005878	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
440085005879	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
440085005880	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
440085005881	putative molybdopterin cofactor binding site [chemical binding]; other site
440085005882	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
440085005883	putative molybdopterin cofactor binding site; other site
440085005884	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
440085005885	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
440085005886	quinone interaction residues [chemical binding]; other site
440085005887	active site
440085005888	catalytic residues [active]
440085005889	FMN binding site [chemical binding]; other site
440085005890	substrate binding site [chemical binding]; other site
440085005891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
440085005892	Predicted transcriptional regulator [Transcription]; Region: COG2932
440085005893	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
440085005894	Catalytic site [active]
440085005895	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
440085005896	serine acetyltransferase; Provisional; Region: cysE; PRK11132
440085005897	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
440085005898	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
440085005899	trimer interface [polypeptide binding]; other site
440085005900	active site
440085005901	substrate binding site [chemical binding]; other site
440085005902	CoA binding site [chemical binding]; other site
440085005903	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
440085005904	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085005905	non-specific DNA binding site [nucleotide binding]; other site
440085005906	salt bridge; other site
440085005907	sequence-specific DNA binding site [nucleotide binding]; other site
440085005908	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
440085005909	ADP binding site [chemical binding]; other site
440085005910	magnesium binding site [ion binding]; other site
440085005911	putative shikimate binding site; other site
440085005912	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085005913	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
440085005914	dimer interface [polypeptide binding]; other site
440085005915	phosphorylation site [posttranslational modification]
440085005916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085005917	ATP binding site [chemical binding]; other site
440085005918	Mg2+ binding site [ion binding]; other site
440085005919	G-X-G motif; other site
440085005920	osmolarity response regulator; Provisional; Region: ompR; PRK09468
440085005921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085005922	active site
440085005923	phosphorylation site [posttranslational modification]
440085005924	intermolecular recognition site; other site
440085005925	dimerization interface [polypeptide binding]; other site
440085005926	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085005927	DNA binding site [nucleotide binding]
440085005928	Response regulator receiver domain; Region: Response_reg; pfam00072
440085005929	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
440085005930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085005931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085005932	dimer interface [polypeptide binding]; other site
440085005933	phosphorylation site [posttranslational modification]
440085005934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085005935	ATP binding site [chemical binding]; other site
440085005936	Mg2+ binding site [ion binding]; other site
440085005937	G-X-G motif; other site
440085005938	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
440085005939	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085005940	active site
440085005941	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085005942	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
440085005943	ligand binding site [chemical binding]; other site
440085005944	flexible hinge region; other site
440085005945	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085005946	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
440085005947	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
440085005948	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085005949	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085005950	N-terminal plug; other site
440085005951	ligand-binding site [chemical binding]; other site
440085005952	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
440085005953	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
440085005954	Moco binding site; other site
440085005955	metal coordination site [ion binding]; other site
440085005956	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
440085005957	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
440085005958	FAD binding pocket [chemical binding]; other site
440085005959	FAD binding motif [chemical binding]; other site
440085005960	phosphate binding motif [ion binding]; other site
440085005961	beta-alpha-beta structure motif; other site
440085005962	NAD binding pocket [chemical binding]; other site
440085005963	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
440085005964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
440085005965	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
440085005966	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
440085005967	hinge; other site
440085005968	active site
440085005969	cytidylate kinase; Provisional; Region: cmk; PRK00023
440085005970	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
440085005971	CMP-binding site; other site
440085005972	The sites determining sugar specificity; other site
440085005973	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
440085005974	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
440085005975	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
440085005976	homodimer interface [polypeptide binding]; other site
440085005977	active site
440085005978	TDP-binding site; other site
440085005979	acceptor substrate-binding pocket; other site
440085005980	Creatinine amidohydrolase; Region: Creatininase; pfam02633
440085005981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085005982	PAS domain; Region: PAS_9; pfam13426
440085005983	putative active site [active]
440085005984	heme pocket [chemical binding]; other site
440085005985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085005986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085005987	metal binding site [ion binding]; metal-binding site
440085005988	active site
440085005989	I-site; other site
440085005990	CsbD-like; Region: CsbD; pfam05532
440085005991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
440085005992	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085005993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085005994	putative substrate translocation pore; other site
440085005995	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
440085005996	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
440085005997	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
440085005998	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
440085005999	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
440085006000	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
440085006001	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
440085006002	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085006003	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
440085006004	acyl-activating enzyme (AAE) consensus motif; other site
440085006005	acyl-activating enzyme (AAE) consensus motif; other site
440085006006	putative AMP binding site [chemical binding]; other site
440085006007	putative active site [active]
440085006008	putative CoA binding site [chemical binding]; other site
440085006009	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
440085006010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085006011	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
440085006012	dimerization interface [polypeptide binding]; other site
440085006013	substrate binding pocket [chemical binding]; other site
440085006014	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
440085006015	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
440085006016	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
440085006017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085006018	motif II; other site
440085006019	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085006020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085006021	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085006022	putative effector binding pocket; other site
440085006023	dimerization interface [polypeptide binding]; other site
440085006024	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
440085006025	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085006026	Zn binding site [ion binding]; other site
440085006027	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
440085006028	Zn binding site [ion binding]; other site
440085006029	Predicted esterase [General function prediction only]; Region: COG0400
440085006030	putative hydrolase; Provisional; Region: PRK11460
440085006031	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
440085006032	AAA domain; Region: AAA_23; pfam13476
440085006033	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
440085006034	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
440085006035	S17 interaction site [polypeptide binding]; other site
440085006036	S8 interaction site; other site
440085006037	16S rRNA interaction site [nucleotide binding]; other site
440085006038	streptomycin interaction site [chemical binding]; other site
440085006039	23S rRNA interaction site [nucleotide binding]; other site
440085006040	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
440085006041	30S ribosomal protein S7; Validated; Region: PRK05302
440085006042	elongation factor G; Reviewed; Region: PRK00007
440085006043	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
440085006044	G1 box; other site
440085006045	putative GEF interaction site [polypeptide binding]; other site
440085006046	GTP/Mg2+ binding site [chemical binding]; other site
440085006047	Switch I region; other site
440085006048	G2 box; other site
440085006049	G3 box; other site
440085006050	Switch II region; other site
440085006051	G4 box; other site
440085006052	G5 box; other site
440085006053	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
440085006054	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
440085006055	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
440085006056	elongation factor Tu; Reviewed; Region: PRK00049
440085006057	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
440085006058	G1 box; other site
440085006059	GEF interaction site [polypeptide binding]; other site
440085006060	GTP/Mg2+ binding site [chemical binding]; other site
440085006061	Switch I region; other site
440085006062	G2 box; other site
440085006063	G3 box; other site
440085006064	Switch II region; other site
440085006065	G4 box; other site
440085006066	G5 box; other site
440085006067	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
440085006068	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
440085006069	Antibiotic Binding Site [chemical binding]; other site
440085006070	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
440085006071	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
440085006072	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
440085006073	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
440085006074	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
440085006075	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
440085006076	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
440085006077	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
440085006078	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
440085006079	putative translocon binding site; other site
440085006080	protein-rRNA interface [nucleotide binding]; other site
440085006081	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
440085006082	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
440085006083	G-X-X-G motif; other site
440085006084	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
440085006085	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
440085006086	23S rRNA interface [nucleotide binding]; other site
440085006087	5S rRNA interface [nucleotide binding]; other site
440085006088	putative antibiotic binding site [chemical binding]; other site
440085006089	L25 interface [polypeptide binding]; other site
440085006090	L27 interface [polypeptide binding]; other site
440085006091	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
440085006092	23S rRNA interface [nucleotide binding]; other site
440085006093	putative translocon interaction site; other site
440085006094	signal recognition particle (SRP54) interaction site; other site
440085006095	L23 interface [polypeptide binding]; other site
440085006096	trigger factor interaction site; other site
440085006097	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
440085006098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006099	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085006100	Walker A motif; other site
440085006101	ATP binding site [chemical binding]; other site
440085006102	Walker B motif; other site
440085006103	arginine finger; other site
440085006104	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
440085006105	nudix motif; other site
440085006106	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
440085006107	MarR family; Region: MarR; pfam01047
440085006108	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
440085006109	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
440085006110	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
440085006111	alphaNTD - beta interaction site [polypeptide binding]; other site
440085006112	alphaNTD homodimer interface [polypeptide binding]; other site
440085006113	alphaNTD - beta' interaction site [polypeptide binding]; other site
440085006114	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
440085006115	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
440085006116	30S ribosomal protein S11; Validated; Region: PRK05309
440085006117	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
440085006118	30S ribosomal protein S13; Region: bact_S13; TIGR03631
440085006119	adenylate kinase; Reviewed; Region: adk; PRK00279
440085006120	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
440085006121	AMP-binding site [chemical binding]; other site
440085006122	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
440085006123	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
440085006124	SecY translocase; Region: SecY; pfam00344
440085006125	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
440085006126	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
440085006127	23S rRNA binding site [nucleotide binding]; other site
440085006128	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
440085006129	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
440085006130	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
440085006131	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
440085006132	5S rRNA interface [nucleotide binding]; other site
440085006133	23S rRNA interface [nucleotide binding]; other site
440085006134	L5 interface [polypeptide binding]; other site
440085006135	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
440085006136	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
440085006137	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
440085006138	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
440085006139	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
440085006140	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
440085006141	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
440085006142	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
440085006143	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
440085006144	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
440085006145	RNA binding site [nucleotide binding]; other site
440085006146	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
440085006147	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
440085006148	Catalytic site; other site
440085006149	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
440085006150	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085006151	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085006152	metal binding site [ion binding]; metal-binding site
440085006153	active site
440085006154	I-site; other site
440085006155	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
440085006156	salicylate hydroxylase; Provisional; Region: PRK08163
440085006157	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
440085006158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
440085006159	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
440085006160	active site
440085006161	hypothetical protein; Reviewed; Region: PRK00024
440085006162	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
440085006163	MPN+ (JAMM) motif; other site
440085006164	Zinc-binding site [ion binding]; other site
440085006165	Uncharacterized conserved protein [Function unknown]; Region: COG2308
440085006166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
440085006167	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
440085006168	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
440085006169	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
440085006170	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
440085006171	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
440085006172	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
440085006173	active site
440085006174	NAD-dependent deacetylase; Provisional; Region: PRK00481
440085006175	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
440085006176	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
440085006177	Domain of unknown function DUF21; Region: DUF21; pfam01595
440085006178	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
440085006179	Transporter associated domain; Region: CorC_HlyC; smart01091
440085006180	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085006181	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085006182	Probable Catalytic site; other site
440085006183	metal-binding site
440085006184	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085006185	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085006186	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
440085006187	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085006188	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085006189	protein binding site [polypeptide binding]; other site
440085006190	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085006191	protein binding site [polypeptide binding]; other site
440085006192	Phasin protein; Region: Phasin_2; cl11491
440085006193	phasin; Region: phasin_2; TIGR01985
440085006194	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085006195	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085006196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085006197	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
440085006198	PAS domain S-box; Region: sensory_box; TIGR00229
440085006199	PAS domain; Region: PAS; smart00091
440085006200	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085006201	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085006202	metal binding site [ion binding]; metal-binding site
440085006203	active site
440085006204	I-site; other site
440085006205	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085006206	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085006207	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085006208	active site
440085006209	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
440085006210	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
440085006211	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
440085006212	CysD dimerization site [polypeptide binding]; other site
440085006213	G1 box; other site
440085006214	putative GEF interaction site [polypeptide binding]; other site
440085006215	GTP/Mg2+ binding site [chemical binding]; other site
440085006216	Switch I region; other site
440085006217	G2 box; other site
440085006218	G3 box; other site
440085006219	Switch II region; other site
440085006220	G4 box; other site
440085006221	G5 box; other site
440085006222	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
440085006223	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
440085006224	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
440085006225	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
440085006226	Active Sites [active]
440085006227	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
440085006228	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
440085006229	Active Sites [active]
440085006230	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
440085006231	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085006232	dimerization interface [polypeptide binding]; other site
440085006233	putative DNA binding site [nucleotide binding]; other site
440085006234	putative Zn2+ binding site [ion binding]; other site
440085006235	AsnC family; Region: AsnC_trans_reg; pfam01037
440085006236	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
440085006237	Flavodoxin; Region: Flavodoxin_1; pfam00258
440085006238	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
440085006239	FAD binding pocket [chemical binding]; other site
440085006240	FAD binding motif [chemical binding]; other site
440085006241	catalytic residues [active]
440085006242	NAD binding pocket [chemical binding]; other site
440085006243	phosphate binding motif [ion binding]; other site
440085006244	beta-alpha-beta structure motif; other site
440085006245	sulfite reductase subunit beta; Provisional; Region: PRK13504
440085006246	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
440085006247	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
440085006248	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085006249	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085006250	N-terminal plug; other site
440085006251	ligand-binding site [chemical binding]; other site
440085006252	pantoate--beta-alanine ligase; Region: panC; TIGR00018
440085006253	Pantoate-beta-alanine ligase; Region: PanC; cd00560
440085006254	active site
440085006255	ATP-binding site [chemical binding]; other site
440085006256	pantoate-binding site; other site
440085006257	HXXH motif; other site
440085006258	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
440085006259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085006260	non-specific DNA binding site [nucleotide binding]; other site
440085006261	salt bridge; other site
440085006262	sequence-specific DNA binding site [nucleotide binding]; other site
440085006263	Cupin domain; Region: Cupin_2; pfam07883
440085006264	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
440085006265	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
440085006266	dimer interface [polypeptide binding]; other site
440085006267	ssDNA binding site [nucleotide binding]; other site
440085006268	tetramer (dimer of dimers) interface [polypeptide binding]; other site
440085006269	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
440085006270	Prostaglandin dehydrogenases; Region: PGDH; cd05288
440085006271	NAD(P) binding site [chemical binding]; other site
440085006272	substrate binding site [chemical binding]; other site
440085006273	dimer interface [polypeptide binding]; other site
440085006274	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
440085006275	Predicted periplasmic protein [Function unknown]; Region: COG3698
440085006276	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
440085006277	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
440085006278	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
440085006279	active site
440085006280	FMN binding site [chemical binding]; other site
440085006281	substrate binding site [chemical binding]; other site
440085006282	homotetramer interface [polypeptide binding]; other site
440085006283	catalytic residue [active]
440085006284	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
440085006285	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
440085006286	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
440085006287	putative dimer interface [polypeptide binding]; other site
440085006288	N-terminal domain interface [polypeptide binding]; other site
440085006289	putative substrate binding pocket (H-site) [chemical binding]; other site
440085006290	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
440085006291	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085006292	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
440085006293	Uncharacterized conserved protein [Function unknown]; Region: COG2835
440085006294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
440085006295	PAS domain; Region: PAS_9; pfam13426
440085006296	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085006297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085006298	dimer interface [polypeptide binding]; other site
440085006299	phosphorylation site [posttranslational modification]
440085006300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085006301	ATP binding site [chemical binding]; other site
440085006302	Mg2+ binding site [ion binding]; other site
440085006303	G-X-G motif; other site
440085006304	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
440085006305	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
440085006306	PilZ domain; Region: PilZ; pfam07238
440085006307	PilZ domain; Region: PilZ; pfam07238
440085006308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
440085006309	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
440085006310	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085006311	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
440085006312	FOG: CBS domain [General function prediction only]; Region: COG0517
440085006313	hypothetical protein; Provisional; Region: PRK10279
440085006314	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
440085006315	active site
440085006316	nucleophile elbow; other site
440085006317	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
440085006318	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
440085006319	GTP cyclohydrolase I; Provisional; Region: PLN03044
440085006320	active site
440085006321	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
440085006322	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
440085006323	trimerization site [polypeptide binding]; other site
440085006324	active site
440085006325	hypothetical protein; Validated; Region: PRK00041
440085006326	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
440085006327	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
440085006328	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
440085006329	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
440085006330	FtsX-like permease family; Region: FtsX; pfam02687
440085006331	FtsX-like permease family; Region: FtsX; pfam02687
440085006332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085006333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085006334	ATP binding site [chemical binding]; other site
440085006335	Mg2+ binding site [ion binding]; other site
440085006336	G-X-G motif; other site
440085006337	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
440085006338	active site
440085006339	hydrophilic channel; other site
440085006340	dimerization interface [polypeptide binding]; other site
440085006341	catalytic residues [active]
440085006342	active site lid [active]
440085006343	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
440085006344	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
440085006345	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
440085006346	Catalytic site [active]
440085006347	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
440085006348	Catalytic site [active]
440085006349	ribonuclease III; Reviewed; Region: rnc; PRK00102
440085006350	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
440085006351	dimerization interface [polypeptide binding]; other site
440085006352	active site
440085006353	metal binding site [ion binding]; metal-binding site
440085006354	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
440085006355	dsRNA binding site [nucleotide binding]; other site
440085006356	GTPase Era; Reviewed; Region: era; PRK00089
440085006357	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
440085006358	G1 box; other site
440085006359	GTP/Mg2+ binding site [chemical binding]; other site
440085006360	Switch I region; other site
440085006361	G2 box; other site
440085006362	Switch II region; other site
440085006363	G3 box; other site
440085006364	G4 box; other site
440085006365	G5 box; other site
440085006366	KH domain; Region: KH_2; pfam07650
440085006367	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
440085006368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085006369	S-adenosylmethionine binding site [chemical binding]; other site
440085006370	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
440085006371	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085006372	RNA binding surface [nucleotide binding]; other site
440085006373	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
440085006374	active site
440085006375	uracil binding [chemical binding]; other site
440085006376	Sel1-like repeats; Region: SEL1; smart00671
440085006377	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
440085006378	Sel1-like repeats; Region: SEL1; smart00671
440085006379	Sel1 repeat; Region: Sel1; cl02723
440085006380	Sel1-like repeats; Region: SEL1; smart00671
440085006381	Sel1-like repeats; Region: SEL1; smart00671
440085006382	Sel1-like repeats; Region: SEL1; smart00671
440085006383	Sel1-like repeats; Region: SEL1; smart00671
440085006384	potassium uptake protein; Region: kup; TIGR00794
440085006385	K+ potassium transporter; Region: K_trans; pfam02705
440085006386	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
440085006387	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
440085006388	putative active site [active]
440085006389	Ap4A binding site [chemical binding]; other site
440085006390	nudix motif; other site
440085006391	putative metal binding site [ion binding]; other site
440085006392	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085006393	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085006394	putative CheW interface [polypeptide binding]; other site
440085006395	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
440085006396	NodB motif; other site
440085006397	putative active site [active]
440085006398	putative catalytic site [active]
440085006399	Zn binding site [ion binding]; other site
440085006400	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
440085006401	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
440085006402	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
440085006403	protein binding site [polypeptide binding]; other site
440085006404	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
440085006405	Catalytic dyad [active]
440085006406	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
440085006407	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085006408	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
440085006409	citrate-proton symporter; Provisional; Region: PRK15075
440085006410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085006411	putative substrate translocation pore; other site
440085006412	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
440085006413	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085006414	metal binding site [ion binding]; metal-binding site
440085006415	active site
440085006416	I-site; other site
440085006417	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085006418	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
440085006419	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
440085006420	putative catalytic residue [active]
440085006421	argininosuccinate synthase; Provisional; Region: PRK13820
440085006422	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
440085006423	ANP binding site [chemical binding]; other site
440085006424	Substrate Binding Site II [chemical binding]; other site
440085006425	Substrate Binding Site I [chemical binding]; other site
440085006426	phosphoglycolate phosphatase; Provisional; Region: PRK13222
440085006427	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085006428	motif II; other site
440085006429	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
440085006430	tetramer (dimer of dimers) interface [polypeptide binding]; other site
440085006431	active site
440085006432	dimer interface [polypeptide binding]; other site
440085006433	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
440085006434	O-Antigen ligase; Region: Wzy_C; pfam04932
440085006435	glutathione reductase; Validated; Region: PRK06116
440085006436	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085006437	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085006438	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
440085006439	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
440085006440	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
440085006441	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
440085006442	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
440085006443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085006444	FeS/SAM binding site; other site
440085006445	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
440085006446	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
440085006447	Fe-S cluster binding site [ion binding]; other site
440085006448	active site
440085006449	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085006450	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085006451	NAD binding site [chemical binding]; other site
440085006452	catalytic Zn binding site [ion binding]; other site
440085006453	structural Zn binding site [ion binding]; other site
440085006454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
440085006455	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
440085006456	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085006457	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085006458	catalytic residue [active]
440085006459	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
440085006460	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085006461	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
440085006462	putative C-terminal domain interface [polypeptide binding]; other site
440085006463	putative GSH binding site (G-site) [chemical binding]; other site
440085006464	putative dimer interface [polypeptide binding]; other site
440085006465	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
440085006466	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
440085006467	putative heme binding pocket [chemical binding]; other site
440085006468	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
440085006469	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
440085006470	putative FMN binding site [chemical binding]; other site
440085006471	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085006472	DNA-binding site [nucleotide binding]; DNA binding site
440085006473	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
440085006474	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085006475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085006476	homodimer interface [polypeptide binding]; other site
440085006477	catalytic residue [active]
440085006478	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
440085006479	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
440085006480	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
440085006481	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
440085006482	active site
440085006483	dimer interface [polypeptide binding]; other site
440085006484	motif 1; other site
440085006485	motif 2; other site
440085006486	motif 3; other site
440085006487	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
440085006488	anticodon binding site; other site
440085006489	fructokinase; Reviewed; Region: PRK09557
440085006490	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
440085006491	nucleotide binding site [chemical binding]; other site
440085006492	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
440085006493	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
440085006494	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
440085006495	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
440085006496	active site
440085006497	HIGH motif; other site
440085006498	nucleotide binding site [chemical binding]; other site
440085006499	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
440085006500	active site
440085006501	KMSKS motif; other site
440085006502	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
440085006503	tRNA binding surface [nucleotide binding]; other site
440085006504	anticodon binding site; other site
440085006505	lipoprotein signal peptidase; Provisional; Region: PRK14796
440085006506	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
440085006507	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
440085006508	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
440085006509	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
440085006510	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
440085006511	YcfA-like protein; Region: YcfA; pfam07927
440085006512	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
440085006513	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
440085006514	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
440085006515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085006516	Zn binding site [ion binding]; other site
440085006517	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
440085006518	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085006519	Zn binding site [ion binding]; other site
440085006520	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
440085006521	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
440085006522	FAD binding pocket [chemical binding]; other site
440085006523	FAD binding motif [chemical binding]; other site
440085006524	phosphate binding motif [ion binding]; other site
440085006525	beta-alpha-beta structure motif; other site
440085006526	NAD binding pocket [chemical binding]; other site
440085006527	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
440085006528	AAA domain; Region: AAA_26; pfam13500
440085006529	Response regulator receiver domain; Region: Response_reg; pfam00072
440085006530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085006531	active site
440085006532	phosphorylation site [posttranslational modification]
440085006533	intermolecular recognition site; other site
440085006534	dimerization interface [polypeptide binding]; other site
440085006535	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
440085006536	FOG: WD40 repeat [General function prediction only]; Region: COG2319
440085006537	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085006538	structural tetrad; other site
440085006539	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
440085006540	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
440085006541	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
440085006542	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
440085006543	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
440085006544	feedback inhibition sensing region; other site
440085006545	homohexameric interface [polypeptide binding]; other site
440085006546	nucleotide binding site [chemical binding]; other site
440085006547	N-acetyl-L-glutamate binding site [chemical binding]; other site
440085006548	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
440085006549	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
440085006550	MOSC domain; Region: MOSC; pfam03473
440085006551	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
440085006552	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
440085006553	MOSC domain; Region: MOSC; pfam03473
440085006554	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
440085006555	Clp amino terminal domain; Region: Clp_N; pfam02861
440085006556	Clp amino terminal domain; Region: Clp_N; pfam02861
440085006557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006558	Walker A motif; other site
440085006559	ATP binding site [chemical binding]; other site
440085006560	Walker B motif; other site
440085006561	arginine finger; other site
440085006562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006563	Walker A motif; other site
440085006564	ATP binding site [chemical binding]; other site
440085006565	Walker B motif; other site
440085006566	arginine finger; other site
440085006567	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
440085006568	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
440085006569	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085006570	active site
440085006571	metal binding site [ion binding]; metal-binding site
440085006572	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
440085006573	Protein of unknown function (DUF423); Region: DUF423; cl01008
440085006574	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
440085006575	G1 box; other site
440085006576	GTP/Mg2+ binding site [chemical binding]; other site
440085006577	Switch I region; other site
440085006578	G2 box; other site
440085006579	G3 box; other site
440085006580	Switch II region; other site
440085006581	G4 box; other site
440085006582	G5 box; other site
440085006583	membrane protein insertase; Provisional; Region: PRK01318
440085006584	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
440085006585	Ribonuclease P; Region: Ribonuclease_P; pfam00825
440085006586	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
440085006587	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
440085006588	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
440085006589	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
440085006590	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085006591	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
440085006592	Walker A/P-loop; other site
440085006593	ATP binding site [chemical binding]; other site
440085006594	Q-loop/lid; other site
440085006595	ABC transporter signature motif; other site
440085006596	Walker B; other site
440085006597	D-loop; other site
440085006598	H-loop/switch region; other site
440085006599	D-cysteine desulfhydrase; Validated; Region: PRK03910
440085006600	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
440085006601	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085006602	catalytic residue [active]
440085006603	hypothetical protein; Validated; Region: PRK09039
440085006604	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085006605	ligand binding site [chemical binding]; other site
440085006606	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
440085006607	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085006608	putative active site [active]
440085006609	metal binding site [ion binding]; metal-binding site
440085006610	homodimer binding site [polypeptide binding]; other site
440085006611	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
440085006612	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
440085006613	Cell division protein ZapA; Region: ZapA; pfam05164
440085006614	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
440085006615	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
440085006616	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
440085006617	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
440085006618	Phosphoglycerate kinase; Region: PGK; pfam00162
440085006619	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
440085006620	substrate binding site [chemical binding]; other site
440085006621	hinge regions; other site
440085006622	ADP binding site [chemical binding]; other site
440085006623	catalytic site [active]
440085006624	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
440085006625	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
440085006626	intersubunit interface [polypeptide binding]; other site
440085006627	active site
440085006628	zinc binding site [ion binding]; other site
440085006629	Na+ binding site [ion binding]; other site
440085006630	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
440085006631	active site
440085006632	thiamine phosphate binding site [chemical binding]; other site
440085006633	pyrophosphate binding site [ion binding]; other site
440085006634	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
440085006635	Sel1-like repeats; Region: SEL1; smart00671
440085006636	Sel1 repeat; Region: Sel1; cl02723
440085006637	Sel1-like repeats; Region: SEL1; smart00671
440085006638	amino acid transporter; Region: 2A0306; TIGR00909
440085006639	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
440085006640	Uncharacterized conserved protein [Function unknown]; Region: COG0062
440085006641	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
440085006642	putative substrate binding site [chemical binding]; other site
440085006643	putative ATP binding site [chemical binding]; other site
440085006644	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
440085006645	Nitrogen regulatory protein P-II; Region: P-II; smart00938
440085006646	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
440085006647	glutaminase; Provisional; Region: PRK00971
440085006648	glutamine synthetase; Region: PLN02284
440085006649	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
440085006650	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
440085006651	glutamine synthetase; Provisional; Region: glnA; PRK09469
440085006652	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
440085006653	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
440085006654	Predicted flavoprotein [General function prediction only]; Region: COG0431
440085006655	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085006656	ribonuclease R; Region: RNase_R; TIGR02063
440085006657	RNB domain; Region: RNB; pfam00773
440085006658	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
440085006659	RNA binding site [nucleotide binding]; other site
440085006660	Protein of unknown function (DUF983); Region: DUF983; cl02211
440085006661	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
440085006662	nudix motif; other site
440085006663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085006664	PAS domain; Region: PAS_9; pfam13426
440085006665	putative active site [active]
440085006666	heme pocket [chemical binding]; other site
440085006667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085006668	PAS domain; Region: PAS_9; pfam13426
440085006669	putative active site [active]
440085006670	heme pocket [chemical binding]; other site
440085006671	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085006672	PAS domain; Region: PAS_9; pfam13426
440085006673	putative active site [active]
440085006674	heme pocket [chemical binding]; other site
440085006675	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085006676	dimer interface [polypeptide binding]; other site
440085006677	putative CheW interface [polypeptide binding]; other site
440085006678	PilZ domain; Region: PilZ; pfam07238
440085006679	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
440085006680	putative NAD(P) binding site [chemical binding]; other site
440085006681	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085006682	epoxyqueuosine reductase; Region: TIGR00276
440085006683	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
440085006684	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085006685	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
440085006686	C-terminal domain interface [polypeptide binding]; other site
440085006687	GSH binding site (G-site) [chemical binding]; other site
440085006688	dimer interface [polypeptide binding]; other site
440085006689	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
440085006690	N-terminal domain interface [polypeptide binding]; other site
440085006691	dimer interface [polypeptide binding]; other site
440085006692	substrate binding pocket (H-site) [chemical binding]; other site
440085006693	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
440085006694	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
440085006695	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
440085006696	heterodimer interface [polypeptide binding]; other site
440085006697	substrate interaction site [chemical binding]; other site
440085006698	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
440085006699	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
440085006700	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
440085006701	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
440085006702	NAD binding site [chemical binding]; other site
440085006703	substrate binding site [chemical binding]; other site
440085006704	homodimer interface [polypeptide binding]; other site
440085006705	active site
440085006706	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
440085006707	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
440085006708	NADP binding site [chemical binding]; other site
440085006709	active site
440085006710	putative substrate binding site [chemical binding]; other site
440085006711	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
440085006712	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
440085006713	substrate binding site; other site
440085006714	tetramer interface; other site
440085006715	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085006716	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085006717	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
440085006718	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
440085006719	Multicopper oxidase; Region: Cu-oxidase; pfam00394
440085006720	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
440085006721	trigger factor; Provisional; Region: tig; PRK01490
440085006722	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
440085006723	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
440085006724	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
440085006725	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
440085006726	oligomer interface [polypeptide binding]; other site
440085006727	active site residues [active]
440085006728	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
440085006729	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
440085006730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006731	Walker A motif; other site
440085006732	ATP binding site [chemical binding]; other site
440085006733	Walker B motif; other site
440085006734	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
440085006735	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
440085006736	Found in ATP-dependent protease La (LON); Region: LON; smart00464
440085006737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006738	Walker A motif; other site
440085006739	ATP binding site [chemical binding]; other site
440085006740	Walker B motif; other site
440085006741	arginine finger; other site
440085006742	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
440085006743	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
440085006744	putative ADP-binding pocket [chemical binding]; other site
440085006745	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085006746	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
440085006747	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
440085006748	Methyltransferase domain; Region: Methyltransf_31; pfam13847
440085006749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085006750	S-adenosylmethionine binding site [chemical binding]; other site
440085006751	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
440085006752	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
440085006753	OPT oligopeptide transporter protein; Region: OPT; cl14607
440085006754	putative oligopeptide transporter, OPT family; Region: TIGR00733
440085006755	ABC-2 type transporter; Region: ABC2_membrane; cl17235
440085006756	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
440085006757	5'-3' exonuclease; Region: 53EXOc; smart00475
440085006758	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
440085006759	active site
440085006760	metal binding site 1 [ion binding]; metal-binding site
440085006761	putative 5' ssDNA interaction site; other site
440085006762	metal binding site 3; metal-binding site
440085006763	metal binding site 2 [ion binding]; metal-binding site
440085006764	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
440085006765	putative DNA binding site [nucleotide binding]; other site
440085006766	putative metal binding site [ion binding]; other site
440085006767	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
440085006768	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
440085006769	active site
440085006770	catalytic site [active]
440085006771	substrate binding site [chemical binding]; other site
440085006772	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
440085006773	active site
440085006774	DNA binding site [nucleotide binding]
440085006775	catalytic site [active]
440085006776	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
440085006777	Active_site [active]
440085006778	GTP-binding protein YchF; Reviewed; Region: PRK09601
440085006779	YchF GTPase; Region: YchF; cd01900
440085006780	G1 box; other site
440085006781	GTP/Mg2+ binding site [chemical binding]; other site
440085006782	Switch I region; other site
440085006783	G2 box; other site
440085006784	Switch II region; other site
440085006785	G3 box; other site
440085006786	G4 box; other site
440085006787	G5 box; other site
440085006788	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
440085006789	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
440085006790	putative active site [active]
440085006791	catalytic residue [active]
440085006792	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
440085006793	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
440085006794	5S rRNA interface [nucleotide binding]; other site
440085006795	CTC domain interface [polypeptide binding]; other site
440085006796	L16 interface [polypeptide binding]; other site
440085006797	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
440085006798	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
440085006799	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
440085006800	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
440085006801	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
440085006802	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
440085006803	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
440085006804	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
440085006805	Type IV pili component [Cell motility and secretion]; Region: COG5461
440085006806	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
440085006807	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
440085006808	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
440085006809	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
440085006810	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
440085006811	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
440085006812	ATP binding site [chemical binding]; other site
440085006813	Walker A motif; other site
440085006814	hexamer interface [polypeptide binding]; other site
440085006815	Walker B motif; other site
440085006816	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
440085006817	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
440085006818	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
440085006819	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
440085006820	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
440085006821	putative active site [active]
440085006822	putative catalytic site [active]
440085006823	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
440085006824	putative active site [active]
440085006825	putative catalytic site [active]
440085006826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085006827	metabolite-proton symporter; Region: 2A0106; TIGR00883
440085006828	putative substrate translocation pore; other site
440085006829	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
440085006830	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
440085006831	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
440085006832	CoenzymeA binding site [chemical binding]; other site
440085006833	subunit interaction site [polypeptide binding]; other site
440085006834	PHB binding site; other site
440085006835	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085006836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085006837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085006838	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085006839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085006840	metal binding site [ion binding]; metal-binding site
440085006841	active site
440085006842	I-site; other site
440085006843	BA14K-like protein; Region: BA14K; pfam07886
440085006844	CsbD-like; Region: CsbD; pfam05532
440085006845	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
440085006846	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
440085006847	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
440085006848	catalytic site [active]
440085006849	putative active site [active]
440085006850	putative substrate binding site [chemical binding]; other site
440085006851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
440085006852	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
440085006853	OstA-like protein; Region: OstA; pfam03968
440085006854	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
440085006855	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
440085006856	Walker A/P-loop; other site
440085006857	ATP binding site [chemical binding]; other site
440085006858	Q-loop/lid; other site
440085006859	ABC transporter signature motif; other site
440085006860	Walker B; other site
440085006861	D-loop; other site
440085006862	H-loop/switch region; other site
440085006863	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
440085006864	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
440085006865	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
440085006866	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
440085006867	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
440085006868	30S subunit binding site; other site
440085006869	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
440085006870	active site
440085006871	phosphorylation site [posttranslational modification]
440085006872	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
440085006873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085006874	Walker A motif; other site
440085006875	ATP binding site [chemical binding]; other site
440085006876	Walker B motif; other site
440085006877	arginine finger; other site
440085006878	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085006879	catalytic core [active]
440085006880	dihydrodipicolinate reductase; Provisional; Region: PRK00048
440085006881	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
440085006882	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
440085006883	MarC family integral membrane protein; Region: MarC; cl00919
440085006884	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085006885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085006886	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
440085006887	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
440085006888	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085006889	active site
440085006890	DNA binding site [nucleotide binding]
440085006891	Int/Topo IB signature motif; other site
440085006892	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085006893	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085006894	metal binding site [ion binding]; metal-binding site
440085006895	active site
440085006896	I-site; other site
440085006897	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
440085006898	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
440085006899	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
440085006900	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
440085006901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085006902	dimer interface [polypeptide binding]; other site
440085006903	conserved gate region; other site
440085006904	ABC-ATPase subunit interface; other site
440085006905	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
440085006906	hypothetical protein; Provisional; Region: PRK08912
440085006907	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085006908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085006909	homodimer interface [polypeptide binding]; other site
440085006910	catalytic residue [active]
440085006911	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085006912	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085006913	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085006914	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
440085006915	Protein export membrane protein; Region: SecD_SecF; cl14618
440085006916	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
440085006917	Protein export membrane protein; Region: SecD_SecF; cl14618
440085006918	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
440085006919	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
440085006920	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
440085006921	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
440085006922	tartrate dehydrogenase; Region: TTC; TIGR02089
440085006923	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
440085006924	benzoylformate decarboxylase; Reviewed; Region: PRK07092
440085006925	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085006926	PYR/PP interface [polypeptide binding]; other site
440085006927	dimer interface [polypeptide binding]; other site
440085006928	TPP binding site [chemical binding]; other site
440085006929	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085006930	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
440085006931	TPP-binding site [chemical binding]; other site
440085006932	dimer interface [polypeptide binding]; other site
440085006933	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
440085006934	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
440085006935	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
440085006936	substrate binding pocket [chemical binding]; other site
440085006937	chain length determination region; other site
440085006938	substrate-Mg2+ binding site; other site
440085006939	catalytic residues [active]
440085006940	aspartate-rich region 1; other site
440085006941	active site lid residues [active]
440085006942	aspartate-rich region 2; other site
440085006943	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
440085006944	Transglycosylase; Region: Transgly; cl17702
440085006945	photolyase PhrII; Region: phr2; TIGR00591
440085006946	DNA photolyase; Region: DNA_photolyase; pfam00875
440085006947	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
440085006948	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
440085006949	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
440085006950	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
440085006951	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
440085006952	dimerization interface [polypeptide binding]; other site
440085006953	ligand binding site [chemical binding]; other site
440085006954	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
440085006955	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
440085006956	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
440085006957	Sulfatase; Region: Sulfatase; cl17466
440085006958	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
440085006959	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
440085006960	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
440085006961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085006962	NAD(P) binding site [chemical binding]; other site
440085006963	active site
440085006964	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
440085006965	active site
440085006966	cosubstrate binding site; other site
440085006967	substrate binding site [chemical binding]; other site
440085006968	catalytic site [active]
440085006969	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
440085006970	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
440085006971	homodimer interface [polypeptide binding]; other site
440085006972	substrate-cofactor binding pocket; other site
440085006973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085006974	catalytic residue [active]
440085006975	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
440085006976	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
440085006977	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
440085006978	[2Fe-2S] cluster binding site [ion binding]; other site
440085006979	cytochrome b; Provisional; Region: CYTB; MTH00191
440085006980	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
440085006981	Qi binding site; other site
440085006982	intrachain domain interface; other site
440085006983	interchain domain interface [polypeptide binding]; other site
440085006984	heme bH binding site [chemical binding]; other site
440085006985	heme bL binding site [chemical binding]; other site
440085006986	Qo binding site; other site
440085006987	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
440085006988	interchain domain interface [polypeptide binding]; other site
440085006989	intrachain domain interface; other site
440085006990	Qi binding site; other site
440085006991	Qo binding site; other site
440085006992	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
440085006993	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
440085006994	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
440085006995	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085006996	active site
440085006997	metal binding site [ion binding]; metal-binding site
440085006998	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
440085006999	putative active site pocket [active]
440085007000	4-fold oligomerization interface [polypeptide binding]; other site
440085007001	metal binding residues [ion binding]; metal-binding site
440085007002	3-fold/trimer interface [polypeptide binding]; other site
440085007003	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
440085007004	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
440085007005	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
440085007006	putative active site [active]
440085007007	oxyanion strand; other site
440085007008	catalytic triad [active]
440085007009	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
440085007010	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
440085007011	catalytic residues [active]
440085007012	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
440085007013	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
440085007014	substrate binding site [chemical binding]; other site
440085007015	glutamase interaction surface [polypeptide binding]; other site
440085007016	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
440085007017	metal binding site [ion binding]; metal-binding site
440085007018	pantothenate kinase; Provisional; Region: PRK05439
440085007019	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
440085007020	ATP-binding site [chemical binding]; other site
440085007021	CoA-binding site [chemical binding]; other site
440085007022	Mg2+-binding site [ion binding]; other site
440085007023	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085007024	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085007025	dimerization interface [polypeptide binding]; other site
440085007026	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085007027	dimer interface [polypeptide binding]; other site
440085007028	putative CheW interface [polypeptide binding]; other site
440085007029	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085007030	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085007031	catalytic residue [active]
440085007032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007033	Response regulator receiver domain; Region: Response_reg; pfam00072
440085007034	active site
440085007035	phosphorylation site [posttranslational modification]
440085007036	intermolecular recognition site; other site
440085007037	dimerization interface [polypeptide binding]; other site
440085007038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085007039	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085007040	phasin; Region: phasin_2; TIGR01985
440085007041	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085007042	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085007043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085007044	putative active site [active]
440085007045	heme pocket [chemical binding]; other site
440085007046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007047	dimer interface [polypeptide binding]; other site
440085007048	phosphorylation site [posttranslational modification]
440085007049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007050	ATP binding site [chemical binding]; other site
440085007051	Mg2+ binding site [ion binding]; other site
440085007052	G-X-G motif; other site
440085007053	acetyl-CoA synthetase; Provisional; Region: PRK00174
440085007054	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
440085007055	active site
440085007056	CoA binding site [chemical binding]; other site
440085007057	acyl-activating enzyme (AAE) consensus motif; other site
440085007058	AMP binding site [chemical binding]; other site
440085007059	acetate binding site [chemical binding]; other site
440085007060	Protein of unknown function, DUF485; Region: DUF485; pfam04341
440085007061	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
440085007062	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
440085007063	Na binding site [ion binding]; other site
440085007064	metabolite-proton symporter; Region: 2A0106; TIGR00883
440085007065	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
440085007066	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
440085007067	purine monophosphate binding site [chemical binding]; other site
440085007068	dimer interface [polypeptide binding]; other site
440085007069	putative catalytic residues [active]
440085007070	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
440085007071	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
440085007072	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
440085007073	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
440085007074	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
440085007075	active site residue [active]
440085007076	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
440085007077	active site residue [active]
440085007078	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085007079	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
440085007080	DEAD-like helicases superfamily; Region: DEXDc; smart00487
440085007081	ATP binding site [chemical binding]; other site
440085007082	Mg++ binding site [ion binding]; other site
440085007083	motif III; other site
440085007084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085007085	nucleotide binding region [chemical binding]; other site
440085007086	ATP-binding site [chemical binding]; other site
440085007087	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
440085007088	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
440085007089	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
440085007090	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
440085007091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007092	Mg2+ binding site [ion binding]; other site
440085007093	G-X-G motif; other site
440085007094	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
440085007095	anchoring element; other site
440085007096	dimer interface [polypeptide binding]; other site
440085007097	ATP binding site [chemical binding]; other site
440085007098	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
440085007099	active site
440085007100	putative metal-binding site [ion binding]; other site
440085007101	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
440085007102	RNA polymerase sigma factor; Provisional; Region: PRK12547
440085007103	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085007104	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085007105	DNA binding residues [nucleotide binding]
440085007106	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
440085007107	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
440085007108	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
440085007109	aspartate aminotransferase; Provisional; Region: PRK05764
440085007110	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085007111	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085007112	homodimer interface [polypeptide binding]; other site
440085007113	catalytic residue [active]
440085007114	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085007115	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
440085007116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007117	dimer interface [polypeptide binding]; other site
440085007118	phosphorylation site [posttranslational modification]
440085007119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007120	ATP binding site [chemical binding]; other site
440085007121	Mg2+ binding site [ion binding]; other site
440085007122	G-X-G motif; other site
440085007123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085007124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007125	active site
440085007126	phosphorylation site [posttranslational modification]
440085007127	intermolecular recognition site; other site
440085007128	dimerization interface [polypeptide binding]; other site
440085007129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085007130	DNA binding site [nucleotide binding]
440085007131	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
440085007132	MarR family; Region: MarR_2; pfam12802
440085007133	branched-chain amino acid aminotransferase; Validated; Region: PRK07544
440085007134	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
440085007135	homodimer interface [polypeptide binding]; other site
440085007136	substrate-cofactor binding pocket; other site
440085007137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085007138	catalytic residue [active]
440085007139	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
440085007140	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
440085007141	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
440085007142	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
440085007143	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
440085007144	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
440085007145	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
440085007146	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
440085007147	TrkA-N domain; Region: TrkA_N; pfam02254
440085007148	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
440085007149	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
440085007150	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
440085007151	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
440085007152	putative active site [active]
440085007153	putative substrate binding site [chemical binding]; other site
440085007154	ATP binding site [chemical binding]; other site
440085007155	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
440085007156	catalytic triad [active]
440085007157	dimer interface [polypeptide binding]; other site
440085007158	hypothetical protein; Validated; Region: PRK00228
440085007159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
440085007160	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
440085007161	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
440085007162	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
440085007163	motif 1; other site
440085007164	active site
440085007165	motif 2; other site
440085007166	motif 3; other site
440085007167	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
440085007168	Predicted transcriptional regulator [Transcription]; Region: COG2378
440085007169	HTH domain; Region: HTH_11; pfam08279
440085007170	WYL domain; Region: WYL; pfam13280
440085007171	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085007172	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085007173	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
440085007174	dimer interface [polypeptide binding]; other site
440085007175	N-terminal domain interface [polypeptide binding]; other site
440085007176	putative substrate binding pocket (H-site) [chemical binding]; other site
440085007177	recombinase A; Provisional; Region: recA; PRK09354
440085007178	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
440085007179	hexamer interface [polypeptide binding]; other site
440085007180	Walker A motif; other site
440085007181	ATP binding site [chemical binding]; other site
440085007182	Walker B motif; other site
440085007183	PAS domain; Region: PAS_9; pfam13426
440085007184	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085007185	PAS domain; Region: PAS_8; pfam13188
440085007186	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085007187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007188	dimer interface [polypeptide binding]; other site
440085007189	phosphorylation site [posttranslational modification]
440085007190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007191	ATP binding site [chemical binding]; other site
440085007192	Mg2+ binding site [ion binding]; other site
440085007193	G-X-G motif; other site
440085007194	Response regulator receiver domain; Region: Response_reg; pfam00072
440085007195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007196	active site
440085007197	phosphorylation site [posttranslational modification]
440085007198	intermolecular recognition site; other site
440085007199	dimerization interface [polypeptide binding]; other site
440085007200	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
440085007201	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
440085007202	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
440085007203	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
440085007204	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
440085007205	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
440085007206	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085007207	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085007208	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
440085007209	Predicted dehydrogenase [General function prediction only]; Region: COG0579
440085007210	hydroxyglutarate oxidase; Provisional; Region: PRK11728
440085007211	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
440085007212	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
440085007213	heme exporter protein CcmC; Region: ccmC; TIGR01191
440085007214	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
440085007215	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
440085007216	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
440085007217	catalytic residues [active]
440085007218	central insert; other site
440085007219	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
440085007220	Cysteine-rich domain; Region: CCG; pfam02754
440085007221	Cysteine-rich domain; Region: CCG; pfam02754
440085007222	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
440085007223	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
440085007224	4Fe-4S binding domain; Region: Fer4; pfam00037
440085007225	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
440085007226	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
440085007227	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
440085007228	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
440085007229	23S rRNA interface [nucleotide binding]; other site
440085007230	L3 interface [polypeptide binding]; other site
440085007231	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
440085007232	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
440085007233	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
440085007234	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
440085007235	active site
440085007236	catalytic residues [active]
440085007237	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
440085007238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085007239	Walker A/P-loop; other site
440085007240	ATP binding site [chemical binding]; other site
440085007241	Q-loop/lid; other site
440085007242	ABC transporter signature motif; other site
440085007243	Walker B; other site
440085007244	D-loop; other site
440085007245	H-loop/switch region; other site
440085007246	Domain of unknown function (DUF329); Region: DUF329; cl01144
440085007247	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
440085007248	active site
440085007249	dimer interface [polypeptide binding]; other site
440085007250	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085007251	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085007252	N-terminal plug; other site
440085007253	ligand-binding site [chemical binding]; other site
440085007254	heme exporter protein CcmB; Region: ccmB; TIGR01190
440085007255	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
440085007256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085007257	Walker A/P-loop; other site
440085007258	ATP binding site [chemical binding]; other site
440085007259	Q-loop/lid; other site
440085007260	ABC transporter signature motif; other site
440085007261	Walker B; other site
440085007262	D-loop; other site
440085007263	H-loop/switch region; other site
440085007264	aconitate hydratase; Validated; Region: PRK09277
440085007265	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
440085007266	substrate binding site [chemical binding]; other site
440085007267	ligand binding site [chemical binding]; other site
440085007268	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
440085007269	substrate binding site [chemical binding]; other site
440085007270	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
440085007271	maleylacetoacetate isomerase; Region: maiA; TIGR01262
440085007272	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
440085007273	C-terminal domain interface [polypeptide binding]; other site
440085007274	GSH binding site (G-site) [chemical binding]; other site
440085007275	putative dimer interface [polypeptide binding]; other site
440085007276	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
440085007277	dimer interface [polypeptide binding]; other site
440085007278	N-terminal domain interface [polypeptide binding]; other site
440085007279	substrate binding pocket (H-site) [chemical binding]; other site
440085007280	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
440085007281	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085007282	EthD domain; Region: EthD; cl17553
440085007283	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
440085007284	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085007285	dimer interface [polypeptide binding]; other site
440085007286	putative CheW interface [polypeptide binding]; other site
440085007287	quinolinate synthetase; Provisional; Region: PRK09375
440085007288	L-aspartate oxidase; Provisional; Region: PRK07512
440085007289	L-aspartate oxidase; Provisional; Region: PRK06175
440085007290	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
440085007291	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
440085007292	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
440085007293	dimerization interface [polypeptide binding]; other site
440085007294	active site
440085007295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085007296	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085007297	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
440085007298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
440085007299	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
440085007300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085007301	FeS/SAM binding site; other site
440085007302	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
440085007303	GSCFA family; Region: GSCFA; pfam08885
440085007304	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
440085007305	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
440085007306	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
440085007307	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
440085007308	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
440085007309	Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488
440085007310	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
440085007311	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085007312	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085007313	protein binding site [polypeptide binding]; other site
440085007314	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085007315	protein binding site [polypeptide binding]; other site
440085007316	HflC protein; Region: hflC; TIGR01932
440085007317	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
440085007318	HflK protein; Region: hflK; TIGR01933
440085007319	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
440085007320	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
440085007321	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
440085007322	folate binding site [chemical binding]; other site
440085007323	NADP+ binding site [chemical binding]; other site
440085007324	thymidylate synthase; Reviewed; Region: thyA; PRK01827
440085007325	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
440085007326	dimerization interface [polypeptide binding]; other site
440085007327	active site
440085007328	CAAX protease self-immunity; Region: Abi; cl00558
440085007329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
440085007330	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
440085007331	Cytochrome P450; Region: p450; cl12078
440085007332	fumarate hydratase; Reviewed; Region: fumC; PRK00485
440085007333	Class II fumarases; Region: Fumarase_classII; cd01362
440085007334	active site
440085007335	tetramer interface [polypeptide binding]; other site
440085007336	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
440085007337	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
440085007338	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
440085007339	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
440085007340	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
440085007341	intersubunit interface [polypeptide binding]; other site
440085007342	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
440085007343	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
440085007344	pyridoxamine kinase; Validated; Region: PRK05756
440085007345	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
440085007346	dimer interface [polypeptide binding]; other site
440085007347	pyridoxal binding site [chemical binding]; other site
440085007348	ATP binding site [chemical binding]; other site
440085007349	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
440085007350	2-isopropylmalate synthase; Validated; Region: PRK00915
440085007351	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
440085007352	active site
440085007353	catalytic residues [active]
440085007354	metal binding site [ion binding]; metal-binding site
440085007355	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
440085007356	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
440085007357	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
440085007358	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
440085007359	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
440085007360	active site
440085007361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085007362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085007363	catalytic residue [active]
440085007364	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
440085007365	HD domain; Region: HD_3; cl17350
440085007366	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085007367	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085007368	S-adenosylmethionine binding site [chemical binding]; other site
440085007369	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
440085007370	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
440085007371	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
440085007372	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
440085007373	YcaO-like family; Region: YcaO; pfam02624
440085007374	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
440085007375	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
440085007376	DNA interaction; other site
440085007377	Metal-binding active site; metal-binding site
440085007378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085007379	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
440085007380	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
440085007381	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
440085007382	putative uracil binding site [chemical binding]; other site
440085007383	putative active site [active]
440085007384	Predicted integral membrane protein [Function unknown]; Region: COG0392
440085007385	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
440085007386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
440085007387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007388	dimer interface [polypeptide binding]; other site
440085007389	phosphorylation site [posttranslational modification]
440085007390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007391	ATP binding site [chemical binding]; other site
440085007392	Mg2+ binding site [ion binding]; other site
440085007393	G-X-G motif; other site
440085007394	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
440085007395	metal-binding site [ion binding]
440085007396	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
440085007397	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
440085007398	metal-binding site [ion binding]
440085007399	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
440085007400	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
440085007401	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
440085007402	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
440085007403	DNA binding residues [nucleotide binding]
440085007404	dimer interface [polypeptide binding]; other site
440085007405	copper binding site [ion binding]; other site
440085007406	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
440085007407	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
440085007408	metal binding site [ion binding]; metal-binding site
440085007409	putative dimer interface [polypeptide binding]; other site
440085007410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
440085007411	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085007412	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
440085007413	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
440085007414	RNA binding site [nucleotide binding]; other site
440085007415	active site
440085007416	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
440085007417	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
440085007418	translation initiation factor IF-2; Region: IF-2; TIGR00487
440085007419	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
440085007420	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
440085007421	G1 box; other site
440085007422	putative GEF interaction site [polypeptide binding]; other site
440085007423	GTP/Mg2+ binding site [chemical binding]; other site
440085007424	Switch I region; other site
440085007425	G2 box; other site
440085007426	G3 box; other site
440085007427	Switch II region; other site
440085007428	G4 box; other site
440085007429	G5 box; other site
440085007430	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
440085007431	Translation-initiation factor 2; Region: IF-2; pfam11987
440085007432	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
440085007433	hypothetical protein; Provisional; Region: PRK09190
440085007434	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
440085007435	putative RNA binding cleft [nucleotide binding]; other site
440085007436	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
440085007437	NusA N-terminal domain; Region: NusA_N; pfam08529
440085007438	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
440085007439	RNA binding site [nucleotide binding]; other site
440085007440	homodimer interface [polypeptide binding]; other site
440085007441	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
440085007442	G-X-X-G motif; other site
440085007443	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
440085007444	G-X-X-G motif; other site
440085007445	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
440085007446	ribosome maturation protein RimP; Reviewed; Region: PRK00092
440085007447	Sm and related proteins; Region: Sm_like; cl00259
440085007448	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
440085007449	putative oligomer interface [polypeptide binding]; other site
440085007450	putative RNA binding site [nucleotide binding]; other site
440085007451	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
440085007452	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
440085007453	trimer interface [polypeptide binding]; other site
440085007454	active site
440085007455	substrate binding site [chemical binding]; other site
440085007456	CoA binding site [chemical binding]; other site
440085007457	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
440085007458	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
440085007459	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
440085007460	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
440085007461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085007462	Coenzyme A binding pocket [chemical binding]; other site
440085007463	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
440085007464	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
440085007465	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
440085007466	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
440085007467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085007468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085007469	WHG domain; Region: WHG; pfam13305
440085007470	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
440085007471	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
440085007472	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
440085007473	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
440085007474	catalytic site [active]
440085007475	active site
440085007476	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
440085007477	putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507
440085007478	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
440085007479	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
440085007480	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
440085007481	active site
440085007482	catalytic site [active]
440085007483	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
440085007484	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
440085007485	active site
440085007486	catalytic site [active]
440085007487	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
440085007488	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
440085007489	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
440085007490	active site
440085007491	homodimer interface [polypeptide binding]; other site
440085007492	catalytic site [active]
440085007493	acceptor binding site [chemical binding]; other site
440085007494	trehalose synthase; Region: treS_nterm; TIGR02456
440085007495	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
440085007496	active site
440085007497	catalytic site [active]
440085007498	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
440085007499	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
440085007500	glycogen branching enzyme; Provisional; Region: PRK05402
440085007501	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
440085007502	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
440085007503	active site
440085007504	catalytic site [active]
440085007505	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
440085007506	hypothetical protein; Provisional; Region: PRK02237
440085007507	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
440085007508	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085007509	FeS/SAM binding site; other site
440085007510	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
440085007511	endonuclease III; Region: ENDO3c; smart00478
440085007512	minor groove reading motif; other site
440085007513	helix-hairpin-helix signature motif; other site
440085007514	substrate binding pocket [chemical binding]; other site
440085007515	active site
440085007516	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
440085007517	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
440085007518	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
440085007519	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
440085007520	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
440085007521	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
440085007522	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085007523	FeS/SAM binding site; other site
440085007524	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
440085007525	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
440085007526	active site
440085007527	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
440085007528	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
440085007529	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
440085007530	P loop; other site
440085007531	GTP binding site [chemical binding]; other site
440085007532	intracellular septation protein A; Reviewed; Region: PRK00259
440085007533	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
440085007534	phytoene desaturase; Region: crtI_fam; TIGR02734
440085007535	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
440085007536	substrate binding pocket [chemical binding]; other site
440085007537	chain length determination region; other site
440085007538	substrate-Mg2+ binding site; other site
440085007539	catalytic residues [active]
440085007540	aspartate-rich region 1; other site
440085007541	active site lid residues [active]
440085007542	aspartate-rich region 2; other site
440085007543	O-methyltransferase; Region: Methyltransf_2; pfam00891
440085007544	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
440085007545	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
440085007546	putative NAD(P) binding site [chemical binding]; other site
440085007547	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085007548	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
440085007549	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
440085007550	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
440085007551	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
440085007552	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
440085007553	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
440085007554	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
440085007555	subunit M interface; other site
440085007556	subunit H interface; other site
440085007557	quinone binding site; other site
440085007558	bacteriopheophytin binding site; other site
440085007559	bacteriochlorophyll binding site; other site
440085007560	cytochrome C subunit interface; other site
440085007561	Fe binding site [ion binding]; other site
440085007562	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
440085007563	subunit H interface; other site
440085007564	subunit L interface; other site
440085007565	bacteriopheophytin binding site; other site
440085007566	carotenoid binding site; other site
440085007567	bacteriochlorophyll binding site; other site
440085007568	cytochrome C interface; other site
440085007569	quinone binding site; other site
440085007570	Fe binding site [ion binding]; other site
440085007571	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
440085007572	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085007573	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
440085007574	Walker A/P-loop; other site
440085007575	ATP binding site [chemical binding]; other site
440085007576	Q-loop/lid; other site
440085007577	ABC transporter signature motif; other site
440085007578	Walker B; other site
440085007579	D-loop; other site
440085007580	H-loop/switch region; other site
440085007581	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
440085007582	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085007583	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085007584	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
440085007585	TPR repeat; Region: TPR_11; pfam13414
440085007586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085007587	binding surface
440085007588	TPR motif; other site
440085007589	TPR repeat; Region: TPR_11; pfam13414
440085007590	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085007591	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085007592	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
440085007593	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
440085007594	catalytic site [active]
440085007595	pyruvate kinase; Provisional; Region: PRK06247
440085007596	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
440085007597	domain interfaces; other site
440085007598	active site
440085007599	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
440085007600	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
440085007601	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
440085007602	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
440085007603	MOFRL family; Region: MOFRL; pfam05161
440085007604	N-formylglutamate amidohydrolase; Region: FGase; cl01522
440085007605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
440085007606	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
440085007607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
440085007608	Peptidase M15; Region: Peptidase_M15_3; cl01194
440085007609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
440085007610	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085007611	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085007612	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085007613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007614	active site
440085007615	phosphorylation site [posttranslational modification]
440085007616	intermolecular recognition site; other site
440085007617	dimerization interface [polypeptide binding]; other site
440085007618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085007619	Walker A motif; other site
440085007620	ATP binding site [chemical binding]; other site
440085007621	Walker B motif; other site
440085007622	arginine finger; other site
440085007623	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085007624	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
440085007625	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
440085007626	active site
440085007627	Zn binding site [ion binding]; other site
440085007628	putative addiction module antidote; Region: doc_partner; TIGR02609
440085007629	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
440085007630	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
440085007631	ABC1 family; Region: ABC1; cl17513
440085007632	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
440085007633	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
440085007634	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
440085007635	ligand binding site [chemical binding]; other site
440085007636	homodimer interface [polypeptide binding]; other site
440085007637	NAD(P) binding site [chemical binding]; other site
440085007638	trimer interface B [polypeptide binding]; other site
440085007639	trimer interface A [polypeptide binding]; other site
440085007640	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
440085007641	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
440085007642	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
440085007643	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
440085007644	DHH family; Region: DHH; pfam01368
440085007645	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085007646	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085007647	ligand binding site [chemical binding]; other site
440085007648	flexible hinge region; other site
440085007649	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085007650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085007651	HWE histidine kinase; Region: HWE_HK; smart00911
440085007652	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
440085007653	Surface antigen; Region: Bac_surface_Ag; pfam01103
440085007654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
440085007655	Family of unknown function (DUF490); Region: DUF490; pfam04357
440085007656	cyanate hydratase; Validated; Region: PRK02866
440085007657	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
440085007658	oligomer interface [polypeptide binding]; other site
440085007659	active site
440085007660	PAS domain S-box; Region: sensory_box; TIGR00229
440085007661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085007662	putative active site [active]
440085007663	heme pocket [chemical binding]; other site
440085007664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085007665	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085007666	Walker A motif; other site
440085007667	ATP binding site [chemical binding]; other site
440085007668	Walker B motif; other site
440085007669	arginine finger; other site
440085007670	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
440085007671	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
440085007672	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
440085007673	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
440085007674	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085007675	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085007676	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085007677	dimerization interface [polypeptide binding]; other site
440085007678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085007679	PAS fold; Region: PAS_7; pfam12860
440085007680	putative active site [active]
440085007681	heme pocket [chemical binding]; other site
440085007682	PAS domain; Region: PAS; smart00091
440085007683	PAS fold; Region: PAS_7; pfam12860
440085007684	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085007685	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085007686	metal binding site [ion binding]; metal-binding site
440085007687	active site
440085007688	I-site; other site
440085007689	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085007690	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
440085007691	dimanganese center [ion binding]; other site
440085007692	Domain of unknown function (DUF892); Region: DUF892; pfam05974
440085007693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085007694	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
440085007695	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
440085007696	Cl- selectivity filter; other site
440085007697	Cl- binding residues [ion binding]; other site
440085007698	pore gating glutamate residue; other site
440085007699	dimer interface [polypeptide binding]; other site
440085007700	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
440085007701	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
440085007702	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
440085007703	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
440085007704	enolase; Provisional; Region: eno; PRK00077
440085007705	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
440085007706	dimer interface [polypeptide binding]; other site
440085007707	metal binding site [ion binding]; metal-binding site
440085007708	substrate binding pocket [chemical binding]; other site
440085007709	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
440085007710	Septum formation initiator; Region: DivIC; cl17659
440085007711	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
440085007712	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
440085007713	tetramer interface [polypeptide binding]; other site
440085007714	TPP-binding site [chemical binding]; other site
440085007715	heterodimer interface [polypeptide binding]; other site
440085007716	phosphorylation loop region [posttranslational modification]
440085007717	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
440085007718	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
440085007719	E3 interaction surface; other site
440085007720	lipoyl attachment site [posttranslational modification]; other site
440085007721	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
440085007722	alpha subunit interface [polypeptide binding]; other site
440085007723	TPP binding site [chemical binding]; other site
440085007724	heterodimer interface [polypeptide binding]; other site
440085007725	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
440085007726	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
440085007727	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
440085007728	E3 interaction surface; other site
440085007729	lipoyl attachment site [posttranslational modification]; other site
440085007730	e3 binding domain; Region: E3_binding; pfam02817
440085007731	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
440085007732	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
440085007733	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
440085007734	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085007735	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
440085007736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085007737	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085007738	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
440085007739	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
440085007740	lipoyl synthase; Provisional; Region: PRK05481
440085007741	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085007742	FeS/SAM binding site; other site
440085007743	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
440085007744	putative coenzyme Q binding site [chemical binding]; other site
440085007745	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
440085007746	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
440085007747	putative DNA binding site [nucleotide binding]; other site
440085007748	putative Zn2+ binding site [ion binding]; other site
440085007749	AsnC family; Region: AsnC_trans_reg; pfam01037
440085007750	ornithine cyclodeaminase; Validated; Region: PRK07589
440085007751	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
440085007752	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
440085007753	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
440085007754	dimer interface [polypeptide binding]; other site
440085007755	active site
440085007756	CoA binding pocket [chemical binding]; other site
440085007757	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
440085007758	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
440085007759	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
440085007760	dimer interface [polypeptide binding]; other site
440085007761	active site
440085007762	CoA binding pocket [chemical binding]; other site
440085007763	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
440085007764	classical (c) SDRs; Region: SDR_c; cd05233
440085007765	NAD(P) binding site [chemical binding]; other site
440085007766	active site
440085007767	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085007768	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
440085007769	iron-sulfur cluster [ion binding]; other site
440085007770	[2Fe-2S] cluster binding site [ion binding]; other site
440085007771	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
440085007772	alpha subunit interface [polypeptide binding]; other site
440085007773	active site
440085007774	substrate binding site [chemical binding]; other site
440085007775	Fe binding site [ion binding]; other site
440085007776	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
440085007777	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
440085007778	putative trimer interface [polypeptide binding]; other site
440085007779	putative CoA binding site [chemical binding]; other site
440085007780	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
440085007781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085007782	binding surface
440085007783	TPR motif; other site
440085007784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085007785	binding surface
440085007786	TPR motif; other site
440085007787	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
440085007788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085007789	TPR motif; other site
440085007790	binding surface
440085007791	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085007792	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
440085007793	active site
440085007794	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
440085007795	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
440085007796	Walker A/P-loop; other site
440085007797	ATP binding site [chemical binding]; other site
440085007798	Q-loop/lid; other site
440085007799	ABC transporter signature motif; other site
440085007800	Walker B; other site
440085007801	D-loop; other site
440085007802	H-loop/switch region; other site
440085007803	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
440085007804	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
440085007805	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085007806	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
440085007807	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
440085007808	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085007809	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085007810	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085007811	Competence-damaged protein; Region: CinA; pfam02464
440085007812	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
440085007813	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
440085007814	substrate binding site; other site
440085007815	dimer interface; other site
440085007816	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
440085007817	homotrimer interaction site [polypeptide binding]; other site
440085007818	zinc binding site [ion binding]; other site
440085007819	CDP-binding sites; other site
440085007820	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
440085007821	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
440085007822	FMN binding site [chemical binding]; other site
440085007823	active site
440085007824	catalytic residues [active]
440085007825	substrate binding site [chemical binding]; other site
440085007826	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085007827	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007828	dimer interface [polypeptide binding]; other site
440085007829	phosphorylation site [posttranslational modification]
440085007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007831	ATP binding site [chemical binding]; other site
440085007832	Mg2+ binding site [ion binding]; other site
440085007833	G-X-G motif; other site
440085007834	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
440085007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007836	active site
440085007837	phosphorylation site [posttranslational modification]
440085007838	intermolecular recognition site; other site
440085007839	dimerization interface [polypeptide binding]; other site
440085007840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085007841	Walker A motif; other site
440085007842	ATP binding site [chemical binding]; other site
440085007843	Walker B motif; other site
440085007844	arginine finger; other site
440085007845	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
440085007846	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
440085007847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085007848	putative Mg++ binding site [ion binding]; other site
440085007849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085007850	nucleotide binding region [chemical binding]; other site
440085007851	ATP-binding site [chemical binding]; other site
440085007852	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
440085007853	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085007854	dimerization interface [polypeptide binding]; other site
440085007855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085007856	putative active site [active]
440085007857	heme pocket [chemical binding]; other site
440085007858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007859	dimer interface [polypeptide binding]; other site
440085007860	phosphorylation site [posttranslational modification]
440085007861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007862	ATP binding site [chemical binding]; other site
440085007863	Mg2+ binding site [ion binding]; other site
440085007864	G-X-G motif; other site
440085007865	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085007866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007867	active site
440085007868	phosphorylation site [posttranslational modification]
440085007869	intermolecular recognition site; other site
440085007870	dimerization interface [polypeptide binding]; other site
440085007871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085007872	Walker A motif; other site
440085007873	ATP binding site [chemical binding]; other site
440085007874	Walker B motif; other site
440085007875	arginine finger; other site
440085007876	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085007877	bacterial Hfq-like; Region: Hfq; cd01716
440085007878	hexamer interface [polypeptide binding]; other site
440085007879	Sm1 motif; other site
440085007880	RNA binding site [nucleotide binding]; other site
440085007881	Sm2 motif; other site
440085007882	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
440085007883	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
440085007884	HflX GTPase family; Region: HflX; cd01878
440085007885	G1 box; other site
440085007886	GTP/Mg2+ binding site [chemical binding]; other site
440085007887	Switch I region; other site
440085007888	G2 box; other site
440085007889	G3 box; other site
440085007890	Switch II region; other site
440085007891	G4 box; other site
440085007892	G5 box; other site
440085007893	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
440085007894	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
440085007895	Sulfate transporter family; Region: Sulfate_transp; pfam00916
440085007896	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
440085007897	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
440085007898	active site clefts [active]
440085007899	zinc binding site [ion binding]; other site
440085007900	dimer interface [polypeptide binding]; other site
440085007901	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085007902	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085007903	Protein export membrane protein; Region: SecD_SecF; cl14618
440085007904	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
440085007905	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085007906	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085007907	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
440085007908	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
440085007909	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
440085007910	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
440085007911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085007912	dimerization interface [polypeptide binding]; other site
440085007913	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
440085007914	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085007915	dimer interface [polypeptide binding]; other site
440085007916	putative CheW interface [polypeptide binding]; other site
440085007917	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
440085007918	putative binding surface; other site
440085007919	active site
440085007920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007921	ATP binding site [chemical binding]; other site
440085007922	Mg2+ binding site [ion binding]; other site
440085007923	G-X-G motif; other site
440085007924	CheW-like domain; Region: CheW; pfam01584
440085007925	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085007926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007927	active site
440085007928	phosphorylation site [posttranslational modification]
440085007929	intermolecular recognition site; other site
440085007930	dimerization interface [polypeptide binding]; other site
440085007931	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
440085007932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007933	active site
440085007934	phosphorylation site [posttranslational modification]
440085007935	intermolecular recognition site; other site
440085007936	dimerization interface [polypeptide binding]; other site
440085007937	CheB methylesterase; Region: CheB_methylest; pfam01339
440085007938	Response regulator receiver domain; Region: Response_reg; pfam00072
440085007939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007940	active site
440085007941	phosphorylation site [posttranslational modification]
440085007942	intermolecular recognition site; other site
440085007943	dimerization interface [polypeptide binding]; other site
440085007944	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085007945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085007946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007947	dimer interface [polypeptide binding]; other site
440085007948	phosphorylation site [posttranslational modification]
440085007949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007950	ATP binding site [chemical binding]; other site
440085007951	Mg2+ binding site [ion binding]; other site
440085007952	G-X-G motif; other site
440085007953	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085007954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007955	active site
440085007956	phosphorylation site [posttranslational modification]
440085007957	intermolecular recognition site; other site
440085007958	dimerization interface [polypeptide binding]; other site
440085007959	PAS fold; Region: PAS_4; pfam08448
440085007960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085007961	dimer interface [polypeptide binding]; other site
440085007962	phosphorylation site [posttranslational modification]
440085007963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085007964	ATP binding site [chemical binding]; other site
440085007965	Mg2+ binding site [ion binding]; other site
440085007966	G-X-G motif; other site
440085007967	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085007968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085007969	active site
440085007970	phosphorylation site [posttranslational modification]
440085007971	intermolecular recognition site; other site
440085007972	dimerization interface [polypeptide binding]; other site
440085007973	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
440085007974	FOG: WD40 repeat [General function prediction only]; Region: COG2319
440085007975	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
440085007976	structural tetrad; other site
440085007977	Cytochrome c; Region: Cytochrom_C; cl11414
440085007978	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
440085007979	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
440085007980	MPT binding site; other site
440085007981	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
440085007982	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
440085007983	dimer interface [polypeptide binding]; other site
440085007984	putative functional site; other site
440085007985	putative MPT binding site; other site
440085007986	PBP superfamily domain; Region: PBP_like; pfam12727
440085007987	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
440085007988	Walker A motif; other site
440085007989	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
440085007990	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
440085007991	dimer interface [polypeptide binding]; other site
440085007992	putative functional site; other site
440085007993	putative MPT binding site; other site
440085007994	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
440085007995	PBP superfamily domain; Region: PBP_like; pfam12727
440085007996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
440085007997	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
440085007998	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
440085007999	Walker A/P-loop; other site
440085008000	ATP binding site [chemical binding]; other site
440085008001	Q-loop/lid; other site
440085008002	ABC transporter signature motif; other site
440085008003	Walker B; other site
440085008004	D-loop; other site
440085008005	H-loop/switch region; other site
440085008006	PBP superfamily domain; Region: PBP_like_2; pfam12849
440085008007	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
440085008008	PRC-barrel domain; Region: PRC; pfam05239
440085008009	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
440085008010	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
440085008011	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
440085008012	Ligand binding site; other site
440085008013	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
440085008014	DXD motif; other site
440085008015	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
440085008016	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085008017	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085008018	catalytic residue [active]
440085008019	TspO/MBR family; Region: TspO_MBR; pfam03073
440085008020	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085008021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008022	active site
440085008023	phosphorylation site [posttranslational modification]
440085008024	intermolecular recognition site; other site
440085008025	dimerization interface [polypeptide binding]; other site
440085008026	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
440085008027	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085008028	active site
440085008029	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
440085008030	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
440085008031	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
440085008032	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
440085008033	Walker A/P-loop; other site
440085008034	ATP binding site [chemical binding]; other site
440085008035	Q-loop/lid; other site
440085008036	ABC transporter signature motif; other site
440085008037	Walker B; other site
440085008038	D-loop; other site
440085008039	H-loop/switch region; other site
440085008040	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
440085008041	Uncharacterized conserved protein [Function unknown]; Region: COG1434
440085008042	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
440085008043	putative active site [active]
440085008044	Response regulator receiver domain; Region: Response_reg; pfam00072
440085008045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008046	active site
440085008047	phosphorylation site [posttranslational modification]
440085008048	intermolecular recognition site; other site
440085008049	dimerization interface [polypeptide binding]; other site
440085008050	gamma-glutamyl kinase; Provisional; Region: PRK05429
440085008051	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
440085008052	nucleotide binding site [chemical binding]; other site
440085008053	homotetrameric interface [polypeptide binding]; other site
440085008054	putative phosphate binding site [ion binding]; other site
440085008055	putative allosteric binding site; other site
440085008056	PUA domain; Region: PUA; pfam01472
440085008057	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
440085008058	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
440085008059	putative catalytic cysteine [active]
440085008060	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
440085008061	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
440085008062	active site
440085008063	(T/H)XGH motif; other site
440085008064	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
440085008065	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
440085008066	Predicted transcriptional regulators [Transcription]; Region: COG1510
440085008067	MarR family; Region: MarR_2; pfam12802
440085008068	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
440085008069	active site
440085008070	catalytic residues [active]
440085008071	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
440085008072	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085008073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085008074	Walker A/P-loop; other site
440085008075	ATP binding site [chemical binding]; other site
440085008076	Q-loop/lid; other site
440085008077	ABC transporter signature motif; other site
440085008078	Walker B; other site
440085008079	D-loop; other site
440085008080	H-loop/switch region; other site
440085008081	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
440085008082	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
440085008083	metal binding site [ion binding]; metal-binding site
440085008084	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
440085008085	MoaE interaction surface [polypeptide binding]; other site
440085008086	MoeB interaction surface [polypeptide binding]; other site
440085008087	thiocarboxylated glycine; other site
440085008088	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
440085008089	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
440085008090	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
440085008091	GIY-YIG motif/motif A; other site
440085008092	active site
440085008093	catalytic site [active]
440085008094	putative DNA binding site [nucleotide binding]; other site
440085008095	metal binding site [ion binding]; metal-binding site
440085008096	UvrB/uvrC motif; Region: UVR; pfam02151
440085008097	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
440085008098	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
440085008099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085008100	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085008101	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
440085008102	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
440085008103	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
440085008104	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
440085008105	Uncharacterized conserved protein [Function unknown]; Region: COG1565
440085008106	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
440085008107	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
440085008108	MgtC family; Region: MgtC; pfam02308
440085008109	phosphoglucomutase; Region: PLN02307
440085008110	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
440085008111	active site
440085008112	substrate binding site [chemical binding]; other site
440085008113	metal binding site [ion binding]; metal-binding site
440085008114	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
440085008115	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
440085008116	pyruvate phosphate dikinase; Provisional; Region: PRK09279
440085008117	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
440085008118	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
440085008119	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
440085008120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085008121	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085008122	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
440085008123	dimer interface [polypeptide binding]; other site
440085008124	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085008125	metal binding site [ion binding]; metal-binding site
440085008126	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008127	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085008128	ligand binding site [chemical binding]; other site
440085008129	flexible hinge region; other site
440085008130	Phosphoprotein; Region: PP_M1; pfam03012
440085008131	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
440085008132	MarR family; Region: MarR; pfam01047
440085008133	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
440085008134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085008135	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
440085008136	two-component response regulator; Provisional; Region: PRK09191
440085008137	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
440085008138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008139	active site
440085008140	phosphorylation site [posttranslational modification]
440085008141	intermolecular recognition site; other site
440085008142	dimerization interface [polypeptide binding]; other site
440085008143	Flagellin N-methylase; Region: FliB; cl00497
440085008144	aminotransferase; Provisional; Region: PRK06105
440085008145	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
440085008146	inhibitor-cofactor binding pocket; inhibition site
440085008147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085008148	catalytic residue [active]
440085008149	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
440085008150	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085008151	putative active site [active]
440085008152	putative metal binding site [ion binding]; other site
440085008153	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
440085008154	AlkA N-terminal domain; Region: AlkA_N; pfam06029
440085008155	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
440085008156	minor groove reading motif; other site
440085008157	helix-hairpin-helix signature motif; other site
440085008158	active site
440085008159	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
440085008160	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
440085008161	catalytic site [active]
440085008162	putative active site [active]
440085008163	putative substrate binding site [chemical binding]; other site
440085008164	HRDC domain; Region: HRDC; pfam00570
440085008165	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
440085008166	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
440085008167	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
440085008168	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
440085008169	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
440085008170	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
440085008171	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
440085008172	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
440085008173	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085008174	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085008175	N-terminal plug; other site
440085008176	ligand-binding site [chemical binding]; other site
440085008177	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
440085008178	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
440085008179	Walker A/P-loop; other site
440085008180	ATP binding site [chemical binding]; other site
440085008181	Q-loop/lid; other site
440085008182	ABC transporter signature motif; other site
440085008183	Walker B; other site
440085008184	D-loop; other site
440085008185	H-loop/switch region; other site
440085008186	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
440085008187	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
440085008188	ABC-ATPase subunit  interface; other site
440085008189	dimer interface [polypeptide binding]; other site
440085008190	putative PBP binding regions; other site
440085008191	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
440085008192	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
440085008193	intersubunit interface [polypeptide binding]; other site
440085008194	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
440085008195	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
440085008196	GMP synthase; Reviewed; Region: guaA; PRK00074
440085008197	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
440085008198	AMP/PPi binding site [chemical binding]; other site
440085008199	candidate oxyanion hole; other site
440085008200	catalytic triad [active]
440085008201	potential glutamine specificity residues [chemical binding]; other site
440085008202	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
440085008203	ATP Binding subdomain [chemical binding]; other site
440085008204	Ligand Binding sites [chemical binding]; other site
440085008205	Dimerization subdomain; other site
440085008206	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
440085008207	active site
440085008208	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
440085008209	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085008210	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
440085008211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085008212	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
440085008213	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
440085008214	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
440085008215	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
440085008216	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
440085008217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
440085008218	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
440085008219	active site
440085008220	cell division protein FtsW; Region: ftsW; TIGR02614
440085008221	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
440085008222	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
440085008223	active site
440085008224	homodimer interface [polypeptide binding]; other site
440085008225	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
440085008226	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
440085008227	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085008228	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
440085008229	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
440085008230	salt bridge; other site
440085008231	non-specific DNA binding site [nucleotide binding]; other site
440085008232	sequence-specific DNA binding site [nucleotide binding]; other site
440085008233	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
440085008234	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
440085008235	FAD binding domain; Region: FAD_binding_4; pfam01565
440085008236	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
440085008237	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
440085008238	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
440085008239	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085008240	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
440085008241	Cell division protein FtsQ; Region: FtsQ; pfam03799
440085008242	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
440085008243	Cell division protein FtsA; Region: FtsA; smart00842
440085008244	Cell division protein FtsA; Region: FtsA; pfam14450
440085008245	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
440085008246	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
440085008247	nucleotide binding site [chemical binding]; other site
440085008248	SulA interaction site; other site
440085008249	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
440085008250	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
440085008251	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
440085008252	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
440085008253	active site
440085008254	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
440085008255	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
440085008256	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
440085008257	Walker A/P-loop; other site
440085008258	ATP binding site [chemical binding]; other site
440085008259	Q-loop/lid; other site
440085008260	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
440085008261	ABC transporter signature motif; other site
440085008262	Walker B; other site
440085008263	D-loop; other site
440085008264	H-loop/switch region; other site
440085008265	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
440085008266	yiaA/B two helix domain; Region: YiaAB; cl01759
440085008267	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
440085008268	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
440085008269	putative molybdopterin cofactor binding site [chemical binding]; other site
440085008270	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
440085008271	putative molybdopterin cofactor binding site; other site
440085008272	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
440085008273	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
440085008274	nucleotide binding site [chemical binding]; other site
440085008275	NEF interaction site [polypeptide binding]; other site
440085008276	SBD interface [polypeptide binding]; other site
440085008277	chaperone protein DnaJ; Provisional; Region: PRK10767
440085008278	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
440085008279	HSP70 interaction site [polypeptide binding]; other site
440085008280	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
440085008281	substrate binding site [polypeptide binding]; other site
440085008282	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
440085008283	Zn binding sites [ion binding]; other site
440085008284	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
440085008285	dimer interface [polypeptide binding]; other site
440085008286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085008287	S-adenosylmethionine binding site [chemical binding]; other site
440085008288	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
440085008289	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
440085008290	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
440085008291	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
440085008292	intersubunit interface [polypeptide binding]; other site
440085008293	active site
440085008294	catalytic residue [active]
440085008295	purine nucleoside phosphorylase; Provisional; Region: PRK08202
440085008296	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
440085008297	active site
440085008298	catalytic motif [active]
440085008299	Zn binding site [ion binding]; other site
440085008300	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
440085008301	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
440085008302	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
440085008303	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
440085008304	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
440085008305	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
440085008306	putative acyl-acceptor binding pocket; other site
440085008307	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085008308	active site
440085008309	metal binding site [ion binding]; metal-binding site
440085008310	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085008311	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
440085008312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008313	active site
440085008314	phosphorylation site [posttranslational modification]
440085008315	intermolecular recognition site; other site
440085008316	dimerization interface [polypeptide binding]; other site
440085008317	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085008318	DNA-binding site [nucleotide binding]; DNA binding site
440085008319	RNA-binding motif; other site
440085008320	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085008321	DNA-binding site [nucleotide binding]; DNA binding site
440085008322	RNA-binding motif; other site
440085008323	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
440085008324	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
440085008325	interface (dimer of trimers) [polypeptide binding]; other site
440085008326	Substrate-binding/catalytic site; other site
440085008327	Zn-binding sites [ion binding]; other site
440085008328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085008329	TPR motif; other site
440085008330	binding surface
440085008331	TPR repeat; Region: TPR_11; pfam13414
440085008332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085008333	binding surface
440085008334	TPR motif; other site
440085008335	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
440085008336	Predicted permeases [General function prediction only]; Region: COG0679
440085008337	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
440085008338	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
440085008339	active site
440085008340	nucleotide binding site [chemical binding]; other site
440085008341	HIGH motif; other site
440085008342	KMSKS motif; other site
440085008343	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
440085008344	peptide chain release factor 2; Provisional; Region: PRK07342
440085008345	This domain is found in peptide chain release factors; Region: PCRF; smart00937
440085008346	RF-1 domain; Region: RF-1; pfam00472
440085008347	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
440085008348	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085008349	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
440085008350	catalytic triad [active]
440085008351	Protein of unknown function; Region: DUF3971; pfam13116
440085008352	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
440085008353	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
440085008354	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
440085008355	putative di-iron ligands [ion binding]; other site
440085008356	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
440085008357	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
440085008358	active site
440085008359	HIGH motif; other site
440085008360	dimer interface [polypeptide binding]; other site
440085008361	KMSKS motif; other site
440085008362	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085008363	RNA binding surface [nucleotide binding]; other site
440085008364	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
440085008365	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
440085008366	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
440085008367	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
440085008368	Tetramer interface [polypeptide binding]; other site
440085008369	active site
440085008370	FMN-binding site [chemical binding]; other site
440085008371	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
440085008372	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
440085008373	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
440085008374	dimerization interface [polypeptide binding]; other site
440085008375	active site
440085008376	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
440085008377	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
440085008378	putative active site [active]
440085008379	Zn binding site [ion binding]; other site
440085008380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085008381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085008382	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
440085008383	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
440085008384	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
440085008385	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
440085008386	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
440085008387	carboxyltransferase (CT) interaction site; other site
440085008388	biotinylation site [posttranslational modification]; other site
440085008389	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
440085008390	putative active site pocket [active]
440085008391	dimerization interface [polypeptide binding]; other site
440085008392	putative catalytic residue [active]
440085008393	Acylphosphatase; Region: Acylphosphatase; pfam00708
440085008394	Protein of unknown function, DUF599; Region: DUF599; pfam04654
440085008395	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
440085008396	Uncharacterized conserved protein [Function unknown]; Region: COG1434
440085008397	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
440085008398	putative active site [active]
440085008399	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085008400	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
440085008401	putative C-terminal domain interface [polypeptide binding]; other site
440085008402	putative GSH binding site (G-site) [chemical binding]; other site
440085008403	putative dimer interface [polypeptide binding]; other site
440085008404	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
440085008405	N-terminal domain interface [polypeptide binding]; other site
440085008406	dimer interface [polypeptide binding]; other site
440085008407	substrate binding pocket (H-site) [chemical binding]; other site
440085008408	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085008409	Radical SAM superfamily; Region: Radical_SAM; pfam04055
440085008410	FeS/SAM binding site; other site
440085008411	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
440085008412	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
440085008413	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
440085008414	motif 1; other site
440085008415	dimer interface [polypeptide binding]; other site
440085008416	active site
440085008417	motif 2; other site
440085008418	motif 3; other site
440085008419	elongation factor P; Validated; Region: PRK00529
440085008420	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
440085008421	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
440085008422	RNA binding site [nucleotide binding]; other site
440085008423	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
440085008424	RNA binding site [nucleotide binding]; other site
440085008425	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
440085008426	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085008427	DNA-binding site [nucleotide binding]; DNA binding site
440085008428	RNA-binding motif; other site
440085008429	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085008430	DNA-binding site [nucleotide binding]; DNA binding site
440085008431	RNA-binding motif; other site
440085008432	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
440085008433	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
440085008434	phytoene desaturase; Region: crtI_fam; TIGR02734
440085008435	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
440085008436	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
440085008437	active site lid residues [active]
440085008438	substrate binding pocket [chemical binding]; other site
440085008439	catalytic residues [active]
440085008440	substrate-Mg2+ binding site; other site
440085008441	aspartate-rich region 1; other site
440085008442	aspartate-rich region 2; other site
440085008443	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085008444	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
440085008445	UreF; Region: UreF; pfam01730
440085008446	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
440085008447	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
440085008448	dimer interface [polypeptide binding]; other site
440085008449	catalytic residues [active]
440085008450	Domain of unknown function DUF29; Region: DUF29; pfam01724
440085008451	urease subunit alpha; Reviewed; Region: ureC; PRK13207
440085008452	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
440085008453	subunit interactions [polypeptide binding]; other site
440085008454	active site
440085008455	flap region; other site
440085008456	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
440085008457	HD domain; Region: HD_4; pfam13328
440085008458	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
440085008459	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
440085008460	alpha-gamma subunit interface [polypeptide binding]; other site
440085008461	beta-gamma subunit interface [polypeptide binding]; other site
440085008462	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
440085008463	alpha-beta subunit interface [polypeptide binding]; other site
440085008464	UreD urease accessory protein; Region: UreD; pfam01774
440085008465	Flavin Reductases; Region: FlaRed; cl00801
440085008466	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
440085008467	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
440085008468	active site
440085008469	putative substrate binding pocket [chemical binding]; other site
440085008470	GcrA cell cycle regulator; Region: GcrA; cl11564
440085008471	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085008472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085008473	NAD(P) binding site [chemical binding]; other site
440085008474	active site
440085008475	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
440085008476	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
440085008477	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
440085008478	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
440085008479	threonine dehydratase; Reviewed; Region: PRK09224
440085008480	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
440085008481	tetramer interface [polypeptide binding]; other site
440085008482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085008483	catalytic residue [active]
440085008484	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
440085008485	putative Ile/Val binding site [chemical binding]; other site
440085008486	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
440085008487	putative Ile/Val binding site [chemical binding]; other site
440085008488	PilZ domain; Region: PilZ; pfam07238
440085008489	SlyX; Region: SlyX; pfam04102
440085008490	Porin subfamily; Region: Porin_2; pfam02530
440085008491	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
440085008492	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
440085008493	Class II flagellar assembly regulator; Region: FliX; pfam10768
440085008494	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
440085008495	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
440085008496	Rod binding protein; Region: Rod-binding; cl01626
440085008497	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
440085008498	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
440085008499	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
440085008500	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
440085008501	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
440085008502	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
440085008503	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085008504	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
440085008505	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
440085008506	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
440085008507	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
440085008508	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
440085008509	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
440085008510	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
440085008511	Uncharacterized conserved protein [Function unknown]; Region: COG3334
440085008512	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
440085008513	catalytic residues [active]
440085008514	dimer interface [polypeptide binding]; other site
440085008515	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
440085008516	Transglycosylase SLT domain; Region: SLT_2; pfam13406
440085008517	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085008518	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085008519	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085008520	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
440085008521	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085008522	Elongation factor G, domain IV; Region: EFG_IV; smart00889
440085008523	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
440085008524	Uncharacterized conserved protein [Function unknown]; Region: COG3791
440085008525	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
440085008526	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
440085008527	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
440085008528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008529	dimer interface [polypeptide binding]; other site
440085008530	phosphorylation site [posttranslational modification]
440085008531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008532	ATP binding site [chemical binding]; other site
440085008533	Mg2+ binding site [ion binding]; other site
440085008534	G-X-G motif; other site
440085008535	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085008536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008537	active site
440085008538	phosphorylation site [posttranslational modification]
440085008539	intermolecular recognition site; other site
440085008540	dimerization interface [polypeptide binding]; other site
440085008541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085008542	ATP binding site [chemical binding]; other site
440085008543	Walker A motif; other site
440085008544	Walker B motif; other site
440085008545	arginine finger; other site
440085008546	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085008547	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085008548	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085008549	metal binding site [ion binding]; metal-binding site
440085008550	active site
440085008551	I-site; other site
440085008552	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085008553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008554	PAS fold; Region: PAS_3; pfam08447
440085008555	putative active site [active]
440085008556	heme pocket [chemical binding]; other site
440085008557	PAS fold; Region: PAS_7; pfam12860
440085008558	PAS domain S-box; Region: sensory_box; TIGR00229
440085008559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085008560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085008561	metal binding site [ion binding]; metal-binding site
440085008562	active site
440085008563	I-site; other site
440085008564	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085008565	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
440085008566	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
440085008567	GatB domain; Region: GatB_Yqey; smart00845
440085008568	Cation efflux family; Region: Cation_efflux; pfam01545
440085008569	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
440085008570	hypothetical protein; Provisional; Region: PRK06184
440085008571	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
440085008572	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
440085008573	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
440085008574	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
440085008575	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
440085008576	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
440085008577	DDE superfamily endonuclease; Region: DDE_3; pfam13358
440085008578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
440085008579	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
440085008580	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085008581	ligand binding site [chemical binding]; other site
440085008582	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
440085008583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085008584	ATP binding site [chemical binding]; other site
440085008585	putative Mg++ binding site [ion binding]; other site
440085008586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085008587	nucleotide binding region [chemical binding]; other site
440085008588	ATP-binding site [chemical binding]; other site
440085008589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085008590	EVE domain; Region: EVE; cl00728
440085008591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085008592	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
440085008593	Uncharacterized conserved protein [Function unknown]; Region: COG1479
440085008594	Protein of unknown function DUF262; Region: DUF262; pfam03235
440085008595	Protein of unknown function DUF262; Region: DUF262; pfam03235
440085008596	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
440085008597	T5orf172 domain; Region: T5orf172; pfam10544
440085008598	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
440085008599	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
440085008600	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
440085008601	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
440085008602	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085008603	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085008604	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085008605	active site
440085008606	DNA binding site [nucleotide binding]
440085008607	Int/Topo IB signature motif; other site
440085008608	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085008609	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085008610	TIGR02594 family protein; Region: TIGR02594
440085008611	PAS domain; Region: PAS_9; pfam13426
440085008612	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085008613	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085008614	metal binding site [ion binding]; metal-binding site
440085008615	active site
440085008616	I-site; other site
440085008617	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085008618	PAS fold; Region: PAS_4; pfam08448
440085008619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008620	PAS domain; Region: PAS_9; pfam13426
440085008621	putative active site [active]
440085008622	heme pocket [chemical binding]; other site
440085008623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008624	PAS domain; Region: PAS_9; pfam13426
440085008625	putative active site [active]
440085008626	heme pocket [chemical binding]; other site
440085008627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008628	PAS fold; Region: PAS_3; pfam08447
440085008629	putative active site [active]
440085008630	heme pocket [chemical binding]; other site
440085008631	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085008632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008633	dimer interface [polypeptide binding]; other site
440085008634	phosphorylation site [posttranslational modification]
440085008635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008636	ATP binding site [chemical binding]; other site
440085008637	Mg2+ binding site [ion binding]; other site
440085008638	G-X-G motif; other site
440085008639	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085008640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008641	active site
440085008642	phosphorylation site [posttranslational modification]
440085008643	intermolecular recognition site; other site
440085008644	dimerization interface [polypeptide binding]; other site
440085008645	PAS fold; Region: PAS_4; pfam08448
440085008646	PAS fold; Region: PAS_4; pfam08448
440085008647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008648	putative active site [active]
440085008649	heme pocket [chemical binding]; other site
440085008650	PAS fold; Region: PAS_3; pfam08447
440085008651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008652	PAS fold; Region: PAS_3; pfam08447
440085008653	putative active site [active]
440085008654	heme pocket [chemical binding]; other site
440085008655	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008656	histidine kinase; Provisional; Region: PRK13557
440085008657	putative active site [active]
440085008658	heme pocket [chemical binding]; other site
440085008659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008660	dimer interface [polypeptide binding]; other site
440085008661	phosphorylation site [posttranslational modification]
440085008662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008663	ATP binding site [chemical binding]; other site
440085008664	Mg2+ binding site [ion binding]; other site
440085008665	G-X-G motif; other site
440085008666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008667	active site
440085008668	phosphorylation site [posttranslational modification]
440085008669	intermolecular recognition site; other site
440085008670	dimerization interface [polypeptide binding]; other site
440085008671	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
440085008672	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
440085008673	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
440085008674	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
440085008675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085008676	ATP binding site [chemical binding]; other site
440085008677	Mg2+ binding site [ion binding]; other site
440085008678	G-X-G motif; other site
440085008679	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
440085008680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085008681	ATP binding site [chemical binding]; other site
440085008682	Mg2+ binding site [ion binding]; other site
440085008683	G-X-G motif; other site
440085008684	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
440085008685	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
440085008686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
440085008687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008688	dimer interface [polypeptide binding]; other site
440085008689	phosphorylation site [posttranslational modification]
440085008690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008691	ATP binding site [chemical binding]; other site
440085008692	Mg2+ binding site [ion binding]; other site
440085008693	G-X-G motif; other site
440085008694	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085008695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008696	active site
440085008697	phosphorylation site [posttranslational modification]
440085008698	intermolecular recognition site; other site
440085008699	dimerization interface [polypeptide binding]; other site
440085008700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008701	PAS domain; Region: PAS_9; pfam13426
440085008702	putative active site [active]
440085008703	heme pocket [chemical binding]; other site
440085008704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085008705	HWE histidine kinase; Region: HWE_HK; pfam07536
440085008706	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
440085008707	Predicted membrane protein [Function unknown]; Region: COG4325
440085008708	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
440085008709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085008710	S-adenosylmethionine binding site [chemical binding]; other site
440085008711	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
440085008712	Predicted membrane protein [Function unknown]; Region: COG2323
440085008713	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
440085008714	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085008715	active site
440085008716	catalytic residues [active]
440085008717	DNA binding site [nucleotide binding]
440085008718	Int/Topo IB signature motif; other site
440085008719	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085008720	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085008721	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085008722	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
440085008723	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
440085008724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008725	PAS fold; Region: PAS; pfam00989
440085008726	putative active site [active]
440085008727	heme pocket [chemical binding]; other site
440085008728	Sensors of blue-light using FAD; Region: BLUF; pfam04940
440085008729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008730	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085008731	dimer interface [polypeptide binding]; other site
440085008732	phosphorylation site [posttranslational modification]
440085008733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008734	ATP binding site [chemical binding]; other site
440085008735	Mg2+ binding site [ion binding]; other site
440085008736	G-X-G motif; other site
440085008737	Response regulator receiver domain; Region: Response_reg; pfam00072
440085008738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008739	active site
440085008740	phosphorylation site [posttranslational modification]
440085008741	intermolecular recognition site; other site
440085008742	dimerization interface [polypeptide binding]; other site
440085008743	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085008744	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085008745	NAD binding site [chemical binding]; other site
440085008746	catalytic Zn binding site [ion binding]; other site
440085008747	structural Zn binding site [ion binding]; other site
440085008748	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
440085008749	active site
440085008750	oxyanion hole [active]
440085008751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008752	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085008753	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008754	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085008755	ligand binding site [chemical binding]; other site
440085008756	flexible hinge region; other site
440085008757	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085008758	HTH-like domain; Region: HTH_21; pfam13276
440085008759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
440085008760	Integrase core domain; Region: rve; pfam00665
440085008761	Integrase core domain; Region: rve_3; pfam13683
440085008762	response regulator; Provisional; Region: PRK13435
440085008763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008764	active site
440085008765	phosphorylation site [posttranslational modification]
440085008766	intermolecular recognition site; other site
440085008767	dimerization interface [polypeptide binding]; other site
440085008768	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085008769	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008770	ligand binding site [chemical binding]; other site
440085008771	flexible hinge region; other site
440085008772	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085008773	putative switch regulator; other site
440085008774	non-specific DNA interactions [nucleotide binding]; other site
440085008775	DNA binding site [nucleotide binding]
440085008776	sequence specific DNA binding site [nucleotide binding]; other site
440085008777	putative cAMP binding site [chemical binding]; other site
440085008778	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008779	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
440085008780	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085008781	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085008782	ligand binding site [chemical binding]; other site
440085008783	flexible hinge region; other site
440085008784	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085008785	non-specific DNA interactions [nucleotide binding]; other site
440085008786	DNA binding site [nucleotide binding]
440085008787	sequence specific DNA binding site [nucleotide binding]; other site
440085008788	putative cAMP binding site [chemical binding]; other site
440085008789	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
440085008790	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
440085008791	active site
440085008792	Int/Topo IB signature motif; other site
440085008793	Leucine rich repeat; Region: LRR_8; pfam13855
440085008794	Leucine rich repeat; Region: LRR_8; pfam13855
440085008795	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
440085008796	active site
440085008797	ATP binding site [chemical binding]; other site
440085008798	substrate binding site [chemical binding]; other site
440085008799	activation loop (A-loop); other site
440085008800	Uncharacterized conserved protein [Function unknown]; Region: COG3025
440085008801	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
440085008802	putative active site [active]
440085008803	putative metal binding residues [ion binding]; other site
440085008804	signature motif; other site
440085008805	putative triphosphate binding site [ion binding]; other site
440085008806	CHAD domain; Region: CHAD; pfam05235
440085008807	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
440085008808	putative active site [active]
440085008809	putative metal binding residues [ion binding]; other site
440085008810	signature motif; other site
440085008811	putative dimer interface [polypeptide binding]; other site
440085008812	putative phosphate binding site [ion binding]; other site
440085008813	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
440085008814	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085008815	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
440085008816	DNA binding residues [nucleotide binding]
440085008817	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
440085008818	Uncharacterized conserved protein [Function unknown]; Region: COG2128
440085008819	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
440085008820	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
440085008821	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085008822	catalytic loop [active]
440085008823	iron binding site [ion binding]; other site
440085008824	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085008825	cyclase homology domain; Region: CHD; cd07302
440085008826	nucleotidyl binding site; other site
440085008827	metal binding site [ion binding]; metal-binding site
440085008828	dimer interface [polypeptide binding]; other site
440085008829	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085008830	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085008831	Major royal jelly protein; Region: MRJP; pfam03022
440085008832	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
440085008833	putative heme binding pocket [chemical binding]; other site
440085008834	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
440085008835	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
440085008836	aminotransferase; Validated; Region: PRK09148
440085008837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085008838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085008839	homodimer interface [polypeptide binding]; other site
440085008840	catalytic residue [active]
440085008841	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
440085008842	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
440085008843	putative cation:proton antiport protein; Provisional; Region: PRK10669
440085008844	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
440085008845	TrkA-N domain; Region: TrkA_N; pfam02254
440085008846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
440085008847	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
440085008848	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
440085008849	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
440085008850	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
440085008851	dimer interface [polypeptide binding]; other site
440085008852	motif 1; other site
440085008853	active site
440085008854	motif 2; other site
440085008855	motif 3; other site
440085008856	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085008857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085008858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
440085008859	SnoaL-like domain; Region: SnoaL_2; pfam12680
440085008860	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
440085008861	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
440085008862	tandem repeat interface [polypeptide binding]; other site
440085008863	oligomer interface [polypeptide binding]; other site
440085008864	active site residues [active]
440085008865	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
440085008866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085008867	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
440085008868	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
440085008869	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
440085008870	substrate binding pocket [chemical binding]; other site
440085008871	chain length determination region; other site
440085008872	substrate-Mg2+ binding site; other site
440085008873	catalytic residues [active]
440085008874	aspartate-rich region 1; other site
440085008875	active site lid residues [active]
440085008876	aspartate-rich region 2; other site
440085008877	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
440085008878	Porin subfamily; Region: Porin_2; pfam02530
440085008879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085008880	binding surface
440085008881	TPR motif; other site
440085008882	TPR repeat; Region: TPR_11; pfam13414
440085008883	TPR repeat; Region: TPR_11; pfam13414
440085008884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
440085008885	binding surface
440085008886	TPR motif; other site
440085008887	TPR repeat; Region: TPR_11; pfam13414
440085008888	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
440085008889	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
440085008890	active site
440085008891	non-prolyl cis peptide bond; other site
440085008892	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
440085008893	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
440085008894	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085008895	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
440085008896	Walker A/P-loop; other site
440085008897	ATP binding site [chemical binding]; other site
440085008898	Q-loop/lid; other site
440085008899	ABC transporter signature motif; other site
440085008900	Walker B; other site
440085008901	D-loop; other site
440085008902	H-loop/switch region; other site
440085008903	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
440085008904	putative active site [active]
440085008905	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
440085008906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008907	ATP binding site [chemical binding]; other site
440085008908	Mg2+ binding site [ion binding]; other site
440085008909	G-X-G motif; other site
440085008910	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
440085008911	anchoring element; other site
440085008912	dimer interface [polypeptide binding]; other site
440085008913	ATP binding site [chemical binding]; other site
440085008914	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
440085008915	active site
440085008916	metal binding site [ion binding]; metal-binding site
440085008917	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
440085008918	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
440085008919	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
440085008920	tetramer interface [polypeptide binding]; other site
440085008921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085008922	catalytic residue [active]
440085008923	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
440085008924	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085008925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085008926	Walker A/P-loop; other site
440085008927	ATP binding site [chemical binding]; other site
440085008928	Q-loop/lid; other site
440085008929	ABC transporter signature motif; other site
440085008930	Walker B; other site
440085008931	D-loop; other site
440085008932	H-loop/switch region; other site
440085008933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085008934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085008935	putative substrate translocation pore; other site
440085008936	PRC-barrel domain; Region: PRC; pfam05239
440085008937	SWIB/MDM2 domain; Region: SWIB; pfam02201
440085008938	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
440085008939	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085008940	NAD(P) binding site [chemical binding]; other site
440085008941	active site
440085008942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085008943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085008944	putative substrate translocation pore; other site
440085008945	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085008946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085008947	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
440085008948	catalytic site [active]
440085008949	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
440085008950	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
440085008951	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
440085008952	C-terminal domain interface [polypeptide binding]; other site
440085008953	GSH binding site (G-site) [chemical binding]; other site
440085008954	dimer interface [polypeptide binding]; other site
440085008955	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
440085008956	N-terminal domain interface [polypeptide binding]; other site
440085008957	putative dimer interface [polypeptide binding]; other site
440085008958	active site
440085008959	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
440085008960	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
440085008961	nucleoside/Zn binding site; other site
440085008962	dimer interface [polypeptide binding]; other site
440085008963	catalytic motif [active]
440085008964	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
440085008965	Short C-terminal domain; Region: SHOCT; pfam09851
440085008966	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
440085008967	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
440085008968	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
440085008969	active site
440085008970	catalytic site [active]
440085008971	histidine kinase; Provisional; Region: PRK13557
440085008972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085008973	putative active site [active]
440085008974	heme pocket [chemical binding]; other site
440085008975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085008976	dimer interface [polypeptide binding]; other site
440085008977	phosphorylation site [posttranslational modification]
440085008978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085008979	ATP binding site [chemical binding]; other site
440085008980	Mg2+ binding site [ion binding]; other site
440085008981	G-X-G motif; other site
440085008982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085008983	active site
440085008984	phosphorylation site [posttranslational modification]
440085008985	intermolecular recognition site; other site
440085008986	dimerization interface [polypeptide binding]; other site
440085008987	isocitrate dehydrogenase; Validated; Region: PRK08299
440085008988	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
440085008989	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
440085008990	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
440085008991	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
440085008992	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
440085008993	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
440085008994	putative NAD(P) binding site [chemical binding]; other site
440085008995	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085008996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085008997	dimerization interface [polypeptide binding]; other site
440085008998	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
440085008999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085009000	dimer interface [polypeptide binding]; other site
440085009001	putative CheW interface [polypeptide binding]; other site
440085009002	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085009003	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
440085009004	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
440085009005	homodimer interface [polypeptide binding]; other site
440085009006	substrate-cofactor binding pocket; other site
440085009007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085009008	catalytic residue [active]
440085009009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009010	active site
440085009011	phosphorylation site [posttranslational modification]
440085009012	intermolecular recognition site; other site
440085009013	dimerization interface [polypeptide binding]; other site
440085009014	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
440085009015	Cysteine-rich domain; Region: CCG; pfam02754
440085009016	Cysteine-rich domain; Region: CCG; pfam02754
440085009017	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
440085009018	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
440085009019	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
440085009020	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085009021	ATP binding site [chemical binding]; other site
440085009022	putative Mg++ binding site [ion binding]; other site
440085009023	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085009024	nucleotide binding region [chemical binding]; other site
440085009025	ATP-binding site [chemical binding]; other site
440085009026	DEAD/H associated; Region: DEAD_assoc; pfam08494
440085009027	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085009028	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
440085009029	putative active site [active]
440085009030	putative metal binding site [ion binding]; other site
440085009031	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
440085009032	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
440085009033	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
440085009034	putative ion selectivity filter; other site
440085009035	putative pore gating glutamate residue; other site
440085009036	putative H+/Cl- coupling transport residue; other site
440085009037	short chain dehydrogenase; Provisional; Region: PRK06197
440085009038	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
440085009039	putative NAD(P) binding site [chemical binding]; other site
440085009040	active site
440085009041	thiamine monophosphate kinase; Provisional; Region: PRK05731
440085009042	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
440085009043	ATP binding site [chemical binding]; other site
440085009044	dimerization interface [polypeptide binding]; other site
440085009045	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
440085009046	putative RNA binding site [nucleotide binding]; other site
440085009047	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
440085009048	homopentamer interface [polypeptide binding]; other site
440085009049	active site
440085009050	hypothetical protein; Validated; Region: PRK08238
440085009051	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
440085009052	Predicted membrane protein [Function unknown]; Region: COG2246
440085009053	GtrA-like protein; Region: GtrA; pfam04138
440085009054	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
440085009055	Lumazine binding domain; Region: Lum_binding; pfam00677
440085009056	Lumazine binding domain; Region: Lum_binding; pfam00677
440085009057	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
440085009058	catalytic motif [active]
440085009059	Zn binding site [ion binding]; other site
440085009060	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
440085009061	RibD C-terminal domain; Region: RibD_C; cl17279
440085009062	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
440085009063	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
440085009064	ATP cone domain; Region: ATP-cone; pfam03477
440085009065	Transcriptional regulator; Region: Rrf2; cl17282
440085009066	Predicted transcriptional regulator [Transcription]; Region: COG1959
440085009067	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
440085009068	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
440085009069	dimer interface [polypeptide binding]; other site
440085009070	active site
440085009071	glycine-pyridoxal phosphate binding site [chemical binding]; other site
440085009072	folate binding site [chemical binding]; other site
440085009073	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
440085009074	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
440085009075	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
440085009076	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
440085009077	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
440085009078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
440085009079	Thioredoxin; Region: Thioredoxin_4; pfam13462
440085009080	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
440085009081	Protein of unknown function (DUF721); Region: DUF721; cl02324
440085009082	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
440085009083	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
440085009084	minor groove reading motif; other site
440085009085	helix-hairpin-helix signature motif; other site
440085009086	substrate binding pocket [chemical binding]; other site
440085009087	active site
440085009088	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
440085009089	DNA binding and oxoG recognition site [nucleotide binding]
440085009090	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
440085009091	DNA methylase; Region: N6_N4_Mtase; pfam01555
440085009092	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
440085009093	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
440085009094	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
440085009095	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085009096	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085009097	Porin subfamily; Region: Porin_2; pfam02530
440085009098	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
440085009099	ligand binding site [chemical binding]; other site
440085009100	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085009101	cyclase homology domain; Region: CHD; cd07302
440085009102	nucleotidyl binding site; other site
440085009103	metal binding site [ion binding]; metal-binding site
440085009104	dimer interface [polypeptide binding]; other site
440085009105	HD domain; Region: HD_3; pfam13023
440085009106	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
440085009107	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085009108	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085009109	catalytic residue [active]
440085009110	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
440085009111	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
440085009112	dimer interface [polypeptide binding]; other site
440085009113	active site
440085009114	catalytic residue [active]
440085009115	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
440085009116	SmpB-tmRNA interface; other site
440085009117	Uncharacterized conserved protein [Function unknown]; Region: COG1432
440085009118	LabA_like proteins; Region: LabA; cd10911
440085009119	putative metal binding site [ion binding]; other site
440085009120	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085009121	active site
440085009122	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
440085009123	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085009124	Zn2+ binding site [ion binding]; other site
440085009125	Mg2+ binding site [ion binding]; other site
440085009126	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
440085009127	synthetase active site [active]
440085009128	NTP binding site [chemical binding]; other site
440085009129	metal binding site [ion binding]; metal-binding site
440085009130	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
440085009131	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
440085009132	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
440085009133	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
440085009134	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
440085009135	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
440085009136	Glycoprotease family; Region: Peptidase_M22; pfam00814
440085009137	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
440085009138	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
440085009139	Coenzyme A binding pocket [chemical binding]; other site
440085009140	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
440085009141	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
440085009142	putative acyl-acceptor binding pocket; other site
440085009143	MEKHLA domain; Region: MEKHLA; pfam08670
440085009144	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009145	putative active site [active]
440085009146	heme pocket [chemical binding]; other site
440085009147	Bacterial PH domain; Region: DUF304; pfam03703
440085009148	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
440085009149	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
440085009150	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085009151	FeS/SAM binding site; other site
440085009152	TRAM domain; Region: TRAM; cl01282
440085009153	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
440085009154	PhoH-like protein; Region: PhoH; pfam02562
440085009155	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
440085009156	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
440085009157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
440085009158	Transporter associated domain; Region: CorC_HlyC; smart01091
440085009159	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
440085009160	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
440085009161	putative active site [active]
440085009162	catalytic triad [active]
440085009163	putative dimer interface [polypeptide binding]; other site
440085009164	BA14K-like protein; Region: BA14K; pfam07886
440085009165	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
440085009166	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
440085009167	tetramer interface [polypeptide binding]; other site
440085009168	heme binding pocket [chemical binding]; other site
440085009169	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
440085009170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085009171	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
440085009172	dimerization interface [polypeptide binding]; other site
440085009173	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
440085009174	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
440085009175	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
440085009176	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
440085009177	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
440085009178	putative active site [active]
440085009179	putative metal binding site [ion binding]; other site
440085009180	glutamate racemase; Provisional; Region: PRK00865
440085009181	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
440085009182	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
440085009183	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
440085009184	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
440085009185	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
440085009186	active site
440085009187	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085009188	Protein of unknown function (DUF779); Region: DUF779; pfam05610
440085009189	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
440085009190	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
440085009191	[4Fe-4S] binding site [ion binding]; other site
440085009192	molybdopterin cofactor binding site; other site
440085009193	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
440085009194	molybdopterin cofactor binding site; other site
440085009195	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
440085009196	siroheme synthase; Provisional; Region: cysG; PRK10637
440085009197	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
440085009198	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
440085009199	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
440085009200	active site
440085009201	SAM binding site [chemical binding]; other site
440085009202	homodimer interface [polypeptide binding]; other site
440085009203	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
440085009204	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
440085009205	Cu(I) binding site [ion binding]; other site
440085009206	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085009207	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085009208	active site
440085009209	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
440085009210	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009211	substrate binding pocket [chemical binding]; other site
440085009212	membrane-bound complex binding site; other site
440085009213	hinge residues; other site
440085009214	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
440085009215	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
440085009216	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
440085009217	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
440085009218	metal ion-dependent adhesion site (MIDAS); other site
440085009219	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
440085009220	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
440085009221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085009222	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
440085009223	HSP70 interaction site [polypeptide binding]; other site
440085009224	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
440085009225	hypothetical protein; Provisional; Region: PRK09256
440085009226	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
440085009227	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
440085009228	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085009229	S-adenosylmethionine binding site [chemical binding]; other site
440085009230	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
440085009231	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
440085009232	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
440085009233	active site
440085009234	DNA binding site [nucleotide binding]
440085009235	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
440085009236	DNA binding site [nucleotide binding]
440085009237	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
440085009238	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085009239	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
440085009240	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
440085009241	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
440085009242	substrate binding site [chemical binding]; other site
440085009243	oxyanion hole (OAH) forming residues; other site
440085009244	trimer interface [polypeptide binding]; other site
440085009245	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
440085009246	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
440085009247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085009248	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
440085009249	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
440085009250	dimer interface [polypeptide binding]; other site
440085009251	active site
440085009252	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
440085009253	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
440085009254	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
440085009255	FAD binding site [chemical binding]; other site
440085009256	substrate binding site [chemical binding]; other site
440085009257	catalytic residues [active]
440085009258	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
440085009259	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
440085009260	Sel1-like repeats; Region: SEL1; smart00671
440085009261	Sel1-like repeats; Region: SEL1; smart00671
440085009262	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
440085009263	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
440085009264	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
440085009265	active site
440085009266	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
440085009267	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
440085009268	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
440085009269	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
440085009270	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
440085009271	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
440085009272	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
440085009273	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
440085009274	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
440085009275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085009276	catalytic residue [active]
440085009277	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
440085009278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
440085009279	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
440085009280	Subunit III/VIIa interface [polypeptide binding]; other site
440085009281	Phospholipid binding site [chemical binding]; other site
440085009282	Subunit I/III interface [polypeptide binding]; other site
440085009283	Subunit III/VIb interface [polypeptide binding]; other site
440085009284	Subunit III/VIa interface; other site
440085009285	Subunit III/Vb interface [polypeptide binding]; other site
440085009286	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
440085009287	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
440085009288	UbiA prenyltransferase family; Region: UbiA; pfam01040
440085009289	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
440085009290	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
440085009291	Subunit I/III interface [polypeptide binding]; other site
440085009292	D-pathway; other site
440085009293	Subunit I/VIIc interface [polypeptide binding]; other site
440085009294	Subunit I/IV interface [polypeptide binding]; other site
440085009295	Subunit I/II interface [polypeptide binding]; other site
440085009296	Low-spin heme (heme a) binding site [chemical binding]; other site
440085009297	Subunit I/VIIa interface [polypeptide binding]; other site
440085009298	Subunit I/VIa interface [polypeptide binding]; other site
440085009299	Dimer interface; other site
440085009300	Putative water exit pathway; other site
440085009301	Binuclear center (heme a3/CuB) [ion binding]; other site
440085009302	K-pathway; other site
440085009303	Subunit I/Vb interface [polypeptide binding]; other site
440085009304	Putative proton exit pathway; other site
440085009305	Subunit I/VIb interface; other site
440085009306	Subunit I/VIc interface [polypeptide binding]; other site
440085009307	Electron transfer pathway; other site
440085009308	Subunit I/VIIIb interface [polypeptide binding]; other site
440085009309	Subunit I/VIIb interface [polypeptide binding]; other site
440085009310	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
440085009311	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
440085009312	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
440085009313	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
440085009314	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
440085009315	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
440085009316	active site
440085009317	dimer interface [polypeptide binding]; other site
440085009318	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
440085009319	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
440085009320	active site
440085009321	FMN binding site [chemical binding]; other site
440085009322	substrate binding site [chemical binding]; other site
440085009323	3Fe-4S cluster binding site [ion binding]; other site
440085009324	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
440085009325	domain interface; other site
440085009326	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
440085009327	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
440085009328	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
440085009329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
440085009330	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085009331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009332	active site
440085009333	phosphorylation site [posttranslational modification]
440085009334	intermolecular recognition site; other site
440085009335	dimerization interface [polypeptide binding]; other site
440085009336	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085009337	DNA binding residues [nucleotide binding]
440085009338	dimerization interface [polypeptide binding]; other site
440085009339	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
440085009340	active site
440085009341	catalytic triad [active]
440085009342	oxyanion hole [active]
440085009343	Transglycosylase SLT domain; Region: SLT_2; pfam13406
440085009344	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085009345	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085009346	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085009347	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
440085009348	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
440085009349	NAD binding site [chemical binding]; other site
440085009350	homodimer interface [polypeptide binding]; other site
440085009351	active site
440085009352	substrate binding site [chemical binding]; other site
440085009353	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
440085009354	active site
440085009355	tetramer interface; other site
440085009356	N-formylglutamate amidohydrolase; Region: FGase; cl01522
440085009357	Response regulator receiver domain; Region: Response_reg; pfam00072
440085009358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009359	active site
440085009360	phosphorylation site [posttranslational modification]
440085009361	intermolecular recognition site; other site
440085009362	dimerization interface [polypeptide binding]; other site
440085009363	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
440085009364	GSH binding site [chemical binding]; other site
440085009365	catalytic residues [active]
440085009366	Predicted amidohydrolase [General function prediction only]; Region: COG0388
440085009367	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
440085009368	putative active site [active]
440085009369	catalytic triad [active]
440085009370	dimer interface [polypeptide binding]; other site
440085009371	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
440085009372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009373	PAS domain; Region: PAS_9; pfam13426
440085009374	putative active site [active]
440085009375	heme pocket [chemical binding]; other site
440085009376	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085009377	Histidine kinase; Region: HisKA_2; pfam07568
440085009378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085009379	ATP binding site [chemical binding]; other site
440085009380	Mg2+ binding site [ion binding]; other site
440085009381	G-X-G motif; other site
440085009382	methionine sulfoxide reductase A; Provisional; Region: PRK00058
440085009383	hypothetical protein; Provisional; Region: PRK05208
440085009384	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
440085009385	PRC-barrel domain; Region: PRC; pfam05239
440085009386	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
440085009387	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
440085009388	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
440085009389	catalytic residues [active]
440085009390	argininosuccinate lyase; Provisional; Region: PRK00855
440085009391	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
440085009392	active sites [active]
440085009393	tetramer interface [polypeptide binding]; other site
440085009394	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
440085009395	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085009396	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
440085009397	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
440085009398	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
440085009399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085009400	motif II; other site
440085009401	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
440085009402	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
440085009403	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
440085009404	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
440085009405	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
440085009406	PAS domain; Region: PAS_8; pfam13188
440085009407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009408	PAS fold; Region: PAS_3; pfam08447
440085009409	putative active site [active]
440085009410	heme pocket [chemical binding]; other site
440085009411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009412	PAS fold; Region: PAS_3; pfam08447
440085009413	putative active site [active]
440085009414	heme pocket [chemical binding]; other site
440085009415	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085009416	HWE histidine kinase; Region: HWE_HK; pfam07536
440085009417	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085009418	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085009419	Probable Catalytic site; other site
440085009420	metal-binding site
440085009421	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085009422	active site
440085009423	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
440085009424	Peptidase family M48; Region: Peptidase_M48; pfam01435
440085009425	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
440085009426	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085009427	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085009428	non-specific DNA binding site [nucleotide binding]; other site
440085009429	salt bridge; other site
440085009430	sequence-specific DNA binding site [nucleotide binding]; other site
440085009431	S-adenosylmethionine synthetase; Validated; Region: PRK05250
440085009432	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
440085009433	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
440085009434	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
440085009435	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
440085009436	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
440085009437	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
440085009438	active site
440085009439	interdomain interaction site; other site
440085009440	putative metal-binding site [ion binding]; other site
440085009441	nucleotide binding site [chemical binding]; other site
440085009442	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
440085009443	domain I; other site
440085009444	DNA binding groove [nucleotide binding]
440085009445	phosphate binding site [ion binding]; other site
440085009446	domain II; other site
440085009447	domain III; other site
440085009448	nucleotide binding site [chemical binding]; other site
440085009449	catalytic site [active]
440085009450	domain IV; other site
440085009451	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
440085009452	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
440085009453	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
440085009454	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
440085009455	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
440085009456	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
440085009457	Moco binding site; other site
440085009458	metal coordination site [ion binding]; other site
440085009459	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
440085009460	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
440085009461	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
440085009462	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
440085009463	dihydroorotase; Validated; Region: PRK09059
440085009464	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085009465	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
440085009466	active site
440085009467	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
440085009468	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
440085009469	DNA protecting protein DprA; Region: dprA; TIGR00732
440085009470	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
440085009471	active site
440085009472	catalytic triad [active]
440085009473	oxyanion hole [active]
440085009474	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
440085009475	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
440085009476	conserved cys residue [active]
440085009477	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
440085009478	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
440085009479	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
440085009480	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
440085009481	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
440085009482	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
440085009483	GIY-YIG motif/motif A; other site
440085009484	putative active site [active]
440085009485	putative metal binding site [ion binding]; other site
440085009486	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
440085009487	Protein export membrane protein; Region: SecD_SecF; cl14618
440085009488	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085009489	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085009490	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085009491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085009492	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085009493	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
440085009494	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085009495	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085009496	catalytic residue [active]
440085009497	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
440085009498	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
440085009499	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
440085009500	Usg-like family; Region: Usg; cl11567
440085009501	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
440085009502	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
440085009503	ring oligomerisation interface [polypeptide binding]; other site
440085009504	ATP/Mg binding site [chemical binding]; other site
440085009505	stacking interactions; other site
440085009506	hinge regions; other site
440085009507	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
440085009508	oligomerisation interface [polypeptide binding]; other site
440085009509	mobile loop; other site
440085009510	roof hairpin; other site
440085009511	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
440085009512	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085009513	active site
440085009514	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085009515	NMT1-like family; Region: NMT1_2; pfam13379
440085009516	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
440085009517	Moco binding site; other site
440085009518	metal coordination site [ion binding]; other site
440085009519	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085009520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009521	membrane-bound complex binding site; other site
440085009522	hinge residues; other site
440085009523	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
440085009524	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
440085009525	xanthine permease; Region: pbuX; TIGR03173
440085009526	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
440085009527	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
440085009528	putative catalytic residue [active]
440085009529	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085009530	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085009531	Walker A/P-loop; other site
440085009532	ATP binding site [chemical binding]; other site
440085009533	Q-loop/lid; other site
440085009534	ABC transporter signature motif; other site
440085009535	Walker B; other site
440085009536	D-loop; other site
440085009537	H-loop/switch region; other site
440085009538	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085009539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085009540	dimer interface [polypeptide binding]; other site
440085009541	conserved gate region; other site
440085009542	putative PBP binding loops; other site
440085009543	ABC-ATPase subunit interface; other site
440085009544	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085009545	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009546	substrate binding pocket [chemical binding]; other site
440085009547	membrane-bound complex binding site; other site
440085009548	NosL; Region: NosL; cl01769
440085009549	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085009550	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
440085009551	ligand binding site [chemical binding]; other site
440085009552	flexible hinge region; other site
440085009553	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085009554	putative switch regulator; other site
440085009555	non-specific DNA interactions [nucleotide binding]; other site
440085009556	DNA binding site [nucleotide binding]
440085009557	sequence specific DNA binding site [nucleotide binding]; other site
440085009558	putative cAMP binding site [chemical binding]; other site
440085009559	HEAT repeats; Region: HEAT_2; pfam13646
440085009560	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
440085009561	protein binding surface [polypeptide binding]; other site
440085009562	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
440085009563	putative oxidoreductase; Provisional; Region: PRK08275
440085009564	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
440085009565	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
440085009566	Protein of unknown function (DUF971); Region: DUF971; pfam06155
440085009567	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085009568	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085009569	metal binding site [ion binding]; metal-binding site
440085009570	active site
440085009571	I-site; other site
440085009572	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085009573	Methyltransferase domain; Region: Methyltransf_25; pfam13649
440085009574	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
440085009575	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
440085009576	multimer interface [polypeptide binding]; other site
440085009577	active site
440085009578	catalytic triad [active]
440085009579	dimer interface [polypeptide binding]; other site
440085009580	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
440085009581	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
440085009582	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
440085009583	hypothetical protein; Validated; Region: PRK07581
440085009584	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
440085009585	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
440085009586	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
440085009587	Walker A/P-loop; other site
440085009588	ATP binding site [chemical binding]; other site
440085009589	Q-loop/lid; other site
440085009590	ABC transporter signature motif; other site
440085009591	Walker B; other site
440085009592	D-loop; other site
440085009593	H-loop/switch region; other site
440085009594	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
440085009595	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
440085009596	Walker A/P-loop; other site
440085009597	ATP binding site [chemical binding]; other site
440085009598	Q-loop/lid; other site
440085009599	ABC transporter signature motif; other site
440085009600	Walker B; other site
440085009601	D-loop; other site
440085009602	H-loop/switch region; other site
440085009603	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
440085009604	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
440085009605	TM-ABC transporter signature motif; other site
440085009606	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
440085009607	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
440085009608	TM-ABC transporter signature motif; other site
440085009609	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085009610	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
440085009611	putative ligand binding site [chemical binding]; other site
440085009612	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
440085009613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085009614	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085009615	dimer interface [polypeptide binding]; other site
440085009616	phosphorylation site [posttranslational modification]
440085009617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085009618	ATP binding site [chemical binding]; other site
440085009619	Mg2+ binding site [ion binding]; other site
440085009620	G-X-G motif; other site
440085009621	Response regulator receiver domain; Region: Response_reg; pfam00072
440085009622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009623	active site
440085009624	phosphorylation site [posttranslational modification]
440085009625	intermolecular recognition site; other site
440085009626	dimerization interface [polypeptide binding]; other site
440085009627	Response regulator receiver domain; Region: Response_reg; pfam00072
440085009628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009629	active site
440085009630	phosphorylation site [posttranslational modification]
440085009631	intermolecular recognition site; other site
440085009632	dimerization interface [polypeptide binding]; other site
440085009633	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085009634	DNA binding residues [nucleotide binding]
440085009635	dimerization interface [polypeptide binding]; other site
440085009636	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
440085009637	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
440085009638	active site
440085009639	SAM binding site [chemical binding]; other site
440085009640	homodimer interface [polypeptide binding]; other site
440085009641	Predicted periplasmic protein [Function unknown]; Region: COG3904
440085009642	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
440085009643	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085009644	P-loop; other site
440085009645	Magnesium ion binding site [ion binding]; other site
440085009646	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
440085009647	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
440085009648	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
440085009649	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
440085009650	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
440085009651	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
440085009652	active site
440085009653	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
440085009654	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
440085009655	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
440085009656	active site
440085009657	HIGH motif; other site
440085009658	KMSK motif region; other site
440085009659	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
440085009660	tRNA binding surface [nucleotide binding]; other site
440085009661	anticodon binding site; other site
440085009662	Sporulation related domain; Region: SPOR; pfam05036
440085009663	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
440085009664	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
440085009665	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
440085009666	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
440085009667	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
440085009668	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
440085009669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085009670	putative substrate translocation pore; other site
440085009671	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
440085009672	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085009673	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085009674	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009675	substrate binding pocket [chemical binding]; other site
440085009676	membrane-bound complex binding site; other site
440085009677	hinge residues; other site
440085009678	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085009679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085009680	dimer interface [polypeptide binding]; other site
440085009681	conserved gate region; other site
440085009682	putative PBP binding loops; other site
440085009683	ABC-ATPase subunit interface; other site
440085009684	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
440085009685	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085009686	Walker A/P-loop; other site
440085009687	ATP binding site [chemical binding]; other site
440085009688	Q-loop/lid; other site
440085009689	ABC transporter signature motif; other site
440085009690	Walker B; other site
440085009691	D-loop; other site
440085009692	H-loop/switch region; other site
440085009693	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
440085009694	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
440085009695	active site
440085009696	dimer interface [polypeptide binding]; other site
440085009697	non-prolyl cis peptide bond; other site
440085009698	insertion regions; other site
440085009699	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085009700	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009701	substrate binding pocket [chemical binding]; other site
440085009702	membrane-bound complex binding site; other site
440085009703	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085009704	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085009705	substrate binding pocket [chemical binding]; other site
440085009706	membrane-bound complex binding site; other site
440085009707	hinge residues; other site
440085009708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
440085009709	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
440085009710	cytidine deaminase; Provisional; Region: PRK09027
440085009711	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
440085009712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
440085009713	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
440085009714	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
440085009715	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
440085009716	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
440085009717	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
440085009718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
440085009719	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
440085009720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
440085009721	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
440085009722	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
440085009723	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
440085009724	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
440085009725	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085009726	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085009727	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
440085009728	classical (c) SDRs; Region: SDR_c; cd05233
440085009729	NAD(P) binding site [chemical binding]; other site
440085009730	active site
440085009731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085009732	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
440085009733	putative substrate translocation pore; other site
440085009734	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
440085009735	Beta-lactamase; Region: Beta-lactamase; pfam00144
440085009736	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
440085009737	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
440085009738	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
440085009739	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
440085009740	NAD(P) binding site [chemical binding]; other site
440085009741	catalytic residues [active]
440085009742	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085009743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085009744	dimerization interface [polypeptide binding]; other site
440085009745	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085009746	dimer interface [polypeptide binding]; other site
440085009747	putative CheW interface [polypeptide binding]; other site
440085009748	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
440085009749	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
440085009750	dimer interface [polypeptide binding]; other site
440085009751	active site
440085009752	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
440085009753	catalytic residues [active]
440085009754	substrate binding site [chemical binding]; other site
440085009755	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
440085009756	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085009757	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085009758	acyl-activating enzyme (AAE) consensus motif; other site
440085009759	acyl-activating enzyme (AAE) consensus motif; other site
440085009760	AMP binding site [chemical binding]; other site
440085009761	active site
440085009762	CoA binding site [chemical binding]; other site
440085009763	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
440085009764	Predicted membrane protein [Function unknown]; Region: COG2259
440085009765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085009766	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085009767	putative substrate translocation pore; other site
440085009768	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
440085009769	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
440085009770	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085009771	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085009772	active site
440085009773	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
440085009774	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
440085009775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085009776	S-adenosylmethionine binding site [chemical binding]; other site
440085009777	exopolyphosphatase; Region: exo_poly_only; TIGR03706
440085009778	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
440085009779	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
440085009780	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085009781	active site
440085009782	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
440085009783	putative acyl-acceptor binding pocket; other site
440085009784	phytoene desaturase; Region: crtI_fam; TIGR02734
440085009785	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
440085009786	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
440085009787	catalytic triad [active]
440085009788	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
440085009789	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
440085009790	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
440085009791	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
440085009792	Walker A/P-loop; other site
440085009793	ATP binding site [chemical binding]; other site
440085009794	Q-loop/lid; other site
440085009795	ABC transporter signature motif; other site
440085009796	Walker B; other site
440085009797	D-loop; other site
440085009798	H-loop/switch region; other site
440085009799	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
440085009800	phytoene desaturase; Region: crtI_fam; TIGR02734
440085009801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085009802	HerA helicase [Replication, recombination, and repair]; Region: COG0433
440085009803	Domain of unknown function DUF87; Region: DUF87; pfam01935
440085009804	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
440085009805	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
440085009806	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
440085009807	dimer interaction site [polypeptide binding]; other site
440085009808	substrate-binding tunnel; other site
440085009809	active site
440085009810	catalytic site [active]
440085009811	substrate binding site [chemical binding]; other site
440085009812	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
440085009813	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
440085009814	putative active site [active]
440085009815	putative metal binding site [ion binding]; other site
440085009816	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085009817	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
440085009818	putative C-terminal domain interface [polypeptide binding]; other site
440085009819	putative GSH binding site (G-site) [chemical binding]; other site
440085009820	putative dimer interface [polypeptide binding]; other site
440085009821	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
440085009822	dimer interface [polypeptide binding]; other site
440085009823	N-terminal domain interface [polypeptide binding]; other site
440085009824	putative substrate binding pocket (H-site) [chemical binding]; other site
440085009825	Amidinotransferase; Region: Amidinotransf; cl12043
440085009826	putative membrane protein; Region: HpnL; TIGR03476
440085009827	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
440085009828	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
440085009829	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
440085009830	ligand binding site; other site
440085009831	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
440085009832	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
440085009833	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085009834	FeS/SAM binding site; other site
440085009835	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
440085009836	putative active site [active]
440085009837	YdjC motif; other site
440085009838	Mg binding site [ion binding]; other site
440085009839	putative homodimer interface [polypeptide binding]; other site
440085009840	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
440085009841	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
440085009842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085009843	FeS/SAM binding site; other site
440085009844	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
440085009845	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
440085009846	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
440085009847	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
440085009848	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
440085009849	AAA domain; Region: AAA_33; pfam13671
440085009850	ATP-binding site [chemical binding]; other site
440085009851	Gluconate-6-phosphate binding site [chemical binding]; other site
440085009852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085009853	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
440085009854	active site
440085009855	motif I; other site
440085009856	motif II; other site
440085009857	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
440085009858	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085009859	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085009860	catalytic residue [active]
440085009861	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
440085009862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
440085009863	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
440085009864	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
440085009865	putative acyltransferase; Provisional; Region: PRK05790
440085009866	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
440085009867	dimer interface [polypeptide binding]; other site
440085009868	active site
440085009869	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
440085009870	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
440085009871	NAD(P) binding site [chemical binding]; other site
440085009872	homotetramer interface [polypeptide binding]; other site
440085009873	homodimer interface [polypeptide binding]; other site
440085009874	active site
440085009875	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
440085009876	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
440085009877	putative acyl-acceptor binding pocket; other site
440085009878	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
440085009879	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
440085009880	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
440085009881	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
440085009882	FAD binding domain; Region: FAD_binding_4; pfam01565
440085009883	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
440085009884	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
440085009885	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
440085009886	nudix motif; other site
440085009887	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
440085009888	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
440085009889	inhibitor-cofactor binding pocket; inhibition site
440085009890	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085009891	catalytic residue [active]
440085009892	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
440085009893	catalytic residues [active]
440085009894	catalytic nucleophile [active]
440085009895	Recombinase; Region: Recombinase; pfam07508
440085009896	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
440085009897	PBP superfamily domain; Region: PBP_like; pfam12727
440085009898	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085009899	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085009900	ligand binding site [chemical binding]; other site
440085009901	flexible hinge region; other site
440085009902	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085009903	putative switch regulator; other site
440085009904	non-specific DNA interactions [nucleotide binding]; other site
440085009905	DNA binding site [nucleotide binding]
440085009906	sequence specific DNA binding site [nucleotide binding]; other site
440085009907	putative cAMP binding site [chemical binding]; other site
440085009908	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085009909	OsmC-like protein; Region: OsmC; pfam02566
440085009910	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085009911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
440085009912	NMT1-like family; Region: NMT1_2; pfam13379
440085009913	NMT1/THI5 like; Region: NMT1; pfam09084
440085009914	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085009915	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085009916	Walker A/P-loop; other site
440085009917	ATP binding site [chemical binding]; other site
440085009918	Q-loop/lid; other site
440085009919	ABC transporter signature motif; other site
440085009920	Walker B; other site
440085009921	D-loop; other site
440085009922	H-loop/switch region; other site
440085009923	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
440085009924	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
440085009925	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
440085009926	active site
440085009927	non-prolyl cis peptide bond; other site
440085009928	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
440085009929	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
440085009930	Walker A/P-loop; other site
440085009931	ATP binding site [chemical binding]; other site
440085009932	Q-loop/lid; other site
440085009933	ABC transporter signature motif; other site
440085009934	Walker B; other site
440085009935	D-loop; other site
440085009936	H-loop/switch region; other site
440085009937	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
440085009938	TM-ABC transporter signature motif; other site
440085009939	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
440085009940	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
440085009941	TM-ABC transporter signature motif; other site
440085009942	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
440085009943	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
440085009944	putative ligand binding site [chemical binding]; other site
440085009945	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
440085009946	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
440085009947	Walker A/P-loop; other site
440085009948	ATP binding site [chemical binding]; other site
440085009949	Q-loop/lid; other site
440085009950	ABC transporter signature motif; other site
440085009951	Walker B; other site
440085009952	D-loop; other site
440085009953	H-loop/switch region; other site
440085009954	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
440085009955	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085009956	active site
440085009957	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
440085009958	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
440085009959	putative dimer interface [polypeptide binding]; other site
440085009960	Universal stress protein family; Region: Usp; pfam00582
440085009961	Ligand Binding Site [chemical binding]; other site
440085009962	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085009963	Ligand Binding Site [chemical binding]; other site
440085009964	Protein required for attachment to host cells; Region: Host_attach; pfam10116
440085009965	BON domain; Region: BON; cl02771
440085009966	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085009967	Ligand Binding Site [chemical binding]; other site
440085009968	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085009969	ligand binding site [chemical binding]; other site
440085009970	flexible hinge region; other site
440085009971	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085009972	putative switch regulator; other site
440085009973	non-specific DNA interactions [nucleotide binding]; other site
440085009974	DNA binding site [nucleotide binding]
440085009975	sequence specific DNA binding site [nucleotide binding]; other site
440085009976	putative cAMP binding site [chemical binding]; other site
440085009977	response regulator FixJ; Provisional; Region: fixJ; PRK09390
440085009978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085009979	active site
440085009980	phosphorylation site [posttranslational modification]
440085009981	intermolecular recognition site; other site
440085009982	dimerization interface [polypeptide binding]; other site
440085009983	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085009984	DNA binding residues [nucleotide binding]
440085009985	dimerization interface [polypeptide binding]; other site
440085009986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009987	PAS fold; Region: PAS_3; pfam08447
440085009988	putative active site [active]
440085009989	heme pocket [chemical binding]; other site
440085009990	PAS domain S-box; Region: sensory_box; TIGR00229
440085009991	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085009992	putative active site [active]
440085009993	heme pocket [chemical binding]; other site
440085009994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085009995	dimer interface [polypeptide binding]; other site
440085009996	phosphorylation site [posttranslational modification]
440085009997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085009998	ATP binding site [chemical binding]; other site
440085009999	Mg2+ binding site [ion binding]; other site
440085010000	G-X-G motif; other site
440085010001	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085010002	Ligand Binding Site [chemical binding]; other site
440085010003	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085010004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010005	active site
440085010006	phosphorylation site [posttranslational modification]
440085010007	intermolecular recognition site; other site
440085010008	dimerization interface [polypeptide binding]; other site
440085010009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085010010	Zn2+ binding site [ion binding]; other site
440085010011	Mg2+ binding site [ion binding]; other site
440085010012	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
440085010013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085010014	dimer interface [polypeptide binding]; other site
440085010015	phosphorylation site [posttranslational modification]
440085010016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085010017	ATP binding site [chemical binding]; other site
440085010018	Mg2+ binding site [ion binding]; other site
440085010019	G-X-G motif; other site
440085010020	Response regulator receiver domain; Region: Response_reg; pfam00072
440085010021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010022	active site
440085010023	phosphorylation site [posttranslational modification]
440085010024	intermolecular recognition site; other site
440085010025	dimerization interface [polypeptide binding]; other site
440085010026	Hpt domain; Region: Hpt; pfam01627
440085010027	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
440085010028	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085010029	TadE-like protein; Region: TadE; pfam07811
440085010030	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
440085010031	TadE-like protein; Region: TadE; pfam07811
440085010032	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
440085010033	trimer interface [polypeptide binding]; other site
440085010034	active site
440085010035	substrate binding site [chemical binding]; other site
440085010036	CoA binding site [chemical binding]; other site
440085010037	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
440085010038	ligand-binding site [chemical binding]; other site
440085010039	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085010040	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085010041	TIGR02594 family protein; Region: TIGR02594
440085010042	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
440085010043	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
440085010044	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
440085010045	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
440085010046	ABC-2 type transporter; Region: ABC2_membrane; cl17235
440085010047	Protein of unknown function (DUF563); Region: DUF563; pfam04577
440085010048	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
440085010049	Protein of unknown function (DUF563); Region: DUF563; pfam04577
440085010050	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
440085010051	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
440085010052	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085010053	active site
440085010054	catalytic residues [active]
440085010055	DNA binding site [nucleotide binding]
440085010056	Int/Topo IB signature motif; other site
440085010057	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
440085010058	putative catalytic site [active]
440085010059	putative metal binding site [ion binding]; other site
440085010060	putative phosphate binding site [ion binding]; other site
440085010061	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
440085010062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
440085010063	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085010064	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
440085010065	manganese transport regulator MntR; Provisional; Region: PRK11050
440085010066	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
440085010067	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
440085010068	manganese transport protein MntH; Reviewed; Region: PRK00701
440085010069	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
440085010070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085010071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085010072	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
440085010073	putative dimerization interface [polypeptide binding]; other site
440085010074	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
440085010075	transmembrane helices; other site
440085010076	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
440085010077	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
440085010078	Iron-sulfur protein interface; other site
440085010079	proximal quinone binding site [chemical binding]; other site
440085010080	SdhD (CybS) interface [polypeptide binding]; other site
440085010081	proximal heme binding site [chemical binding]; other site
440085010082	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
440085010083	putative SdhC subunit interface [polypeptide binding]; other site
440085010084	putative proximal heme binding site [chemical binding]; other site
440085010085	putative Iron-sulfur protein interface [polypeptide binding]; other site
440085010086	putative proximal quinone binding site; other site
440085010087	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
440085010088	L-aspartate oxidase; Provisional; Region: PRK06175
440085010089	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
440085010090	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
440085010091	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
440085010092	Protease inhibitor Inh; Region: Inh; pfam02974
440085010093	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
440085010094	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
440085010095	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
440085010096	putative active site [active]
440085010097	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
440085010098	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085010099	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
440085010100	substrate binding site [chemical binding]; other site
440085010101	oxyanion hole (OAH) forming residues; other site
440085010102	trimer interface [polypeptide binding]; other site
440085010103	short chain dehydrogenase; Provisional; Region: PRK08303
440085010104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085010105	NAD(P) binding site [chemical binding]; other site
440085010106	active site
440085010107	short chain dehydrogenase; Provisional; Region: PRK08278
440085010108	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
440085010109	NAD(P) binding site [chemical binding]; other site
440085010110	homodimer interface [polypeptide binding]; other site
440085010111	active site
440085010112	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
440085010113	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
440085010114	Cl binding site [ion binding]; other site
440085010115	oligomer interface [polypeptide binding]; other site
440085010116	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
440085010117	dimerization interface [polypeptide binding]; other site
440085010118	metal binding site [ion binding]; metal-binding site
440085010119	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085010120	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085010121	dimer interface [polypeptide binding]; other site
440085010122	putative CheW interface [polypeptide binding]; other site
440085010123	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
440085010124	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085010125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085010126	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085010127	dimerization interface [polypeptide binding]; other site
440085010128	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
440085010129	GAF domain; Region: GAF; pfam01590
440085010130	GAF domain; Region: GAF_2; pfam13185
440085010131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085010132	dimer interface [polypeptide binding]; other site
440085010133	phosphorylation site [posttranslational modification]
440085010134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085010135	ATP binding site [chemical binding]; other site
440085010136	Mg2+ binding site [ion binding]; other site
440085010137	G-X-G motif; other site
440085010138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085010139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010140	active site
440085010141	phosphorylation site [posttranslational modification]
440085010142	intermolecular recognition site; other site
440085010143	dimerization interface [polypeptide binding]; other site
440085010144	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085010145	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085010146	Domain of unknown function (DUF892); Region: DUF892; cl17410
440085010147	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
440085010148	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
440085010149	minor groove reading motif; other site
440085010150	helix-hairpin-helix signature motif; other site
440085010151	substrate binding pocket [chemical binding]; other site
440085010152	active site
440085010153	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
440085010154	short chain dehydrogenase; Provisional; Region: PRK06197
440085010155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085010156	NAD(P) binding site [chemical binding]; other site
440085010157	active site
440085010158	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
440085010159	Fasciclin domain; Region: Fasciclin; pfam02469
440085010160	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085010161	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085010162	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
440085010163	Uncharacterized conserved protein [Function unknown]; Region: COG3791
440085010164	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085010165	GAF domain; Region: GAF; cl17456
440085010166	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
440085010167	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
440085010168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010169	dimer interface [polypeptide binding]; other site
440085010170	conserved gate region; other site
440085010171	putative PBP binding loops; other site
440085010172	ABC-ATPase subunit interface; other site
440085010173	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085010174	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
440085010175	putative C-terminal domain interface [polypeptide binding]; other site
440085010176	putative GSH binding site (G-site) [chemical binding]; other site
440085010177	putative dimer interface [polypeptide binding]; other site
440085010178	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
440085010179	putative N-terminal domain interface [polypeptide binding]; other site
440085010180	putative dimer interface [polypeptide binding]; other site
440085010181	putative substrate binding pocket (H-site) [chemical binding]; other site
440085010182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085010183	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
440085010184	Walker A/P-loop; other site
440085010185	ATP binding site [chemical binding]; other site
440085010186	Q-loop/lid; other site
440085010187	ABC transporter signature motif; other site
440085010188	Walker B; other site
440085010189	D-loop; other site
440085010190	H-loop/switch region; other site
440085010191	TOBE domain; Region: TOBE; cl01440
440085010192	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
440085010193	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
440085010194	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
440085010195	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
440085010196	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085010197	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085010198	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085010199	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
440085010200	DXD motif; other site
440085010201	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085010202	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
440085010203	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
440085010204	Sulfate transporter family; Region: Sulfate_transp; pfam00916
440085010205	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
440085010206	LrgB-like family; Region: LrgB; pfam04172
440085010207	LrgA family; Region: LrgA; pfam03788
440085010208	tellurium resistance terB-like protein; Region: terB_like; cl11965
440085010209	metal binding site [ion binding]; metal-binding site
440085010210	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085010211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085010212	S-adenosylmethionine binding site [chemical binding]; other site
440085010213	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
440085010214	OstA-like protein; Region: OstA; cl00844
440085010215	Organic solvent tolerance protein; Region: OstA_C; pfam04453
440085010216	Predicted permeases [General function prediction only]; Region: COG0795
440085010217	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
440085010218	Predicted permeases [General function prediction only]; Region: COG0795
440085010219	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
440085010220	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
440085010221	multifunctional aminopeptidase A; Provisional; Region: PRK00913
440085010222	interface (dimer of trimers) [polypeptide binding]; other site
440085010223	Substrate-binding/catalytic site; other site
440085010224	Zn-binding sites [ion binding]; other site
440085010225	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
440085010226	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
440085010227	acyl-activating enzyme (AAE) consensus motif; other site
440085010228	putative AMP binding site [chemical binding]; other site
440085010229	putative active site [active]
440085010230	putative CoA binding site [chemical binding]; other site
440085010231	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
440085010232	Mechanosensitive ion channel; Region: MS_channel; pfam00924
440085010233	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
440085010234	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
440085010235	catalytic residues [active]
440085010236	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085010237	Zn2+ binding site [ion binding]; other site
440085010238	Mg2+ binding site [ion binding]; other site
440085010239	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
440085010240	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
440085010241	hypothetical protein; Provisional; Region: PRK08960
440085010242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085010243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085010244	homodimer interface [polypeptide binding]; other site
440085010245	catalytic residue [active]
440085010246	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
440085010247	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
440085010248	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
440085010249	AMIN domain; Region: AMIN; pfam11741
440085010250	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
440085010251	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
440085010252	active site
440085010253	metal binding site [ion binding]; metal-binding site
440085010254	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
440085010255	Transglycosylase; Region: Transgly; pfam00912
440085010256	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
440085010257	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
440085010258	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
440085010259	active site
440085010260	dimer interface [polypeptide binding]; other site
440085010261	non-prolyl cis peptide bond; other site
440085010262	insertion regions; other site
440085010263	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
440085010264	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
440085010265	Flavin binding site [chemical binding]; other site
440085010266	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
440085010267	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085010268	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
440085010269	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
440085010270	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085010271	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085010272	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085010273	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
440085010274	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
440085010275	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
440085010276	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
440085010277	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
440085010278	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
440085010279	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
440085010280	Ligand binding site; other site
440085010281	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
440085010282	DXD motif; other site
440085010283	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
440085010284	Transposase; Region: DDE_Tnp_ISL3; pfam01610
440085010285	Transposase; Region: DDE_Tnp_ISL3; pfam01610
440085010286	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
440085010287	catalytic triad [active]
440085010288	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
440085010289	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
440085010290	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
440085010291	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
440085010292	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
440085010293	Substrate binding site; other site
440085010294	metal-binding site
440085010295	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
440085010296	NeuB family; Region: NeuB; pfam03102
440085010297	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
440085010298	NeuB binding interface [polypeptide binding]; other site
440085010299	putative substrate binding site [chemical binding]; other site
440085010300	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
440085010301	putative trimer interface [polypeptide binding]; other site
440085010302	putative CoA binding site [chemical binding]; other site
440085010303	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
440085010304	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
440085010305	active site
440085010306	homodimer interface [polypeptide binding]; other site
440085010307	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
440085010308	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971
440085010309	putative active site [active]
440085010310	putative metal binding site [ion binding]; other site
440085010311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085010312	NAD(P) binding site [chemical binding]; other site
440085010313	active site
440085010314	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
440085010315	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
440085010316	inhibitor-cofactor binding pocket; inhibition site
440085010317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085010318	catalytic residue [active]
440085010319	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
440085010320	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
440085010321	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
440085010322	ligand binding site; other site
440085010323	tetramer interface; other site
440085010324	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085010325	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085010326	Probable Catalytic site; other site
440085010327	metal-binding site
440085010328	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010329	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085010330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010331	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
440085010332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085010333	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085010334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085010335	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085010336	HTH-like domain; Region: HTH_21; pfam13276
440085010337	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
440085010338	Integrase core domain; Region: rve; pfam00665
440085010339	Integrase core domain; Region: rve_3; pfam13683
440085010340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085010341	S-adenosylmethionine binding site [chemical binding]; other site
440085010342	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
440085010343	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
440085010344	substrate binding site; other site
440085010345	tetramer interface; other site
440085010346	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
440085010347	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
440085010348	NADP binding site [chemical binding]; other site
440085010349	active site
440085010350	putative substrate binding site [chemical binding]; other site
440085010351	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
440085010352	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
440085010353	NAD binding site [chemical binding]; other site
440085010354	substrate binding site [chemical binding]; other site
440085010355	homodimer interface [polypeptide binding]; other site
440085010356	active site
440085010357	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
440085010358	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
440085010359	Probable Catalytic site; other site
440085010360	metal-binding site
440085010361	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085010362	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085010363	Probable Catalytic site; other site
440085010364	metal-binding site
440085010365	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
440085010366	allophanate hydrolase; Provisional; Region: PRK08186
440085010367	Amidase; Region: Amidase; cl11426
440085010368	urea carboxylase; Region: urea_carbox; TIGR02712
440085010369	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
440085010370	ATP-grasp domain; Region: ATP-grasp_4; cl17255
440085010371	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
440085010372	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
440085010373	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
440085010374	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
440085010375	carboxyltransferase (CT) interaction site; other site
440085010376	biotinylation site [posttranslational modification]; other site
440085010377	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
440085010378	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
440085010379	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
440085010380	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
440085010381	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
440085010382	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
440085010383	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
440085010384	Creatinine amidohydrolase; Region: Creatininase; pfam02633
440085010385	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085010386	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085010387	Walker A/P-loop; other site
440085010388	ATP binding site [chemical binding]; other site
440085010389	Q-loop/lid; other site
440085010390	ABC transporter signature motif; other site
440085010391	Walker B; other site
440085010392	D-loop; other site
440085010393	H-loop/switch region; other site
440085010394	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085010395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010396	dimer interface [polypeptide binding]; other site
440085010397	conserved gate region; other site
440085010398	putative PBP binding loops; other site
440085010399	ABC-ATPase subunit interface; other site
440085010400	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085010401	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
440085010402	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
440085010403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085010404	Walker A/P-loop; other site
440085010405	ATP binding site [chemical binding]; other site
440085010406	Q-loop/lid; other site
440085010407	ABC transporter signature motif; other site
440085010408	Walker B; other site
440085010409	D-loop; other site
440085010410	H-loop/switch region; other site
440085010411	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
440085010412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010413	dimer interface [polypeptide binding]; other site
440085010414	conserved gate region; other site
440085010415	putative PBP binding loops; other site
440085010416	ABC-ATPase subunit interface; other site
440085010417	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
440085010418	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
440085010419	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085010420	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
440085010421	conserved cys residue [active]
440085010422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085010423	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
440085010424	hydroxyglutarate oxidase; Provisional; Region: PRK11728
440085010425	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
440085010426	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
440085010427	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
440085010428	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085010429	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
440085010430	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
440085010431	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
440085010432	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
440085010433	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
440085010434	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
440085010435	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
440085010436	putative deacylase active site [active]
440085010437	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
440085010438	Electron transfer flavoprotein domain; Region: ETF; smart00893
440085010439	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
440085010440	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
440085010441	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
440085010442	4Fe-4S binding domain; Region: Fer4; cl02805
440085010443	Cysteine-rich domain; Region: CCG; pfam02754
440085010444	Cysteine-rich domain; Region: CCG; pfam02754
440085010445	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
440085010446	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
440085010447	putative active site [active]
440085010448	putative FMN binding site [chemical binding]; other site
440085010449	putative substrate binding site [chemical binding]; other site
440085010450	putative catalytic residue [active]
440085010451	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085010452	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
440085010453	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
440085010454	FAD binding pocket [chemical binding]; other site
440085010455	FAD binding motif [chemical binding]; other site
440085010456	phosphate binding motif [ion binding]; other site
440085010457	beta-alpha-beta structure motif; other site
440085010458	NAD binding pocket [chemical binding]; other site
440085010459	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085010460	catalytic loop [active]
440085010461	iron binding site [ion binding]; other site
440085010462	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
440085010463	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
440085010464	[2Fe-2S] cluster binding site [ion binding]; other site
440085010465	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
440085010466	putative alpha subunit interface [polypeptide binding]; other site
440085010467	putative active site [active]
440085010468	putative substrate binding site [chemical binding]; other site
440085010469	Fe binding site [ion binding]; other site
440085010470	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
440085010471	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
440085010472	active site
440085010473	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
440085010474	Phosphotransferase enzyme family; Region: APH; pfam01636
440085010475	active site
440085010476	ATP binding site [chemical binding]; other site
440085010477	substrate binding site [chemical binding]; other site
440085010478	dimer interface [polypeptide binding]; other site
440085010479	Phosphotransferase enzyme family; Region: APH; pfam01636
440085010480	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
440085010481	substrate binding site [chemical binding]; other site
440085010482	allantoate amidohydrolase; Reviewed; Region: PRK09290
440085010483	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
440085010484	active site
440085010485	metal binding site [ion binding]; metal-binding site
440085010486	dimer interface [polypeptide binding]; other site
440085010487	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
440085010488	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085010489	Walker A/P-loop; other site
440085010490	ATP binding site [chemical binding]; other site
440085010491	Q-loop/lid; other site
440085010492	ABC transporter signature motif; other site
440085010493	Walker B; other site
440085010494	D-loop; other site
440085010495	H-loop/switch region; other site
440085010496	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085010497	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
440085010498	Walker A/P-loop; other site
440085010499	ATP binding site [chemical binding]; other site
440085010500	Q-loop/lid; other site
440085010501	ABC transporter signature motif; other site
440085010502	Walker B; other site
440085010503	D-loop; other site
440085010504	H-loop/switch region; other site
440085010505	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
440085010506	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
440085010507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010508	dimer interface [polypeptide binding]; other site
440085010509	conserved gate region; other site
440085010510	putative PBP binding loops; other site
440085010511	ABC-ATPase subunit interface; other site
440085010512	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
440085010513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010514	dimer interface [polypeptide binding]; other site
440085010515	conserved gate region; other site
440085010516	putative PBP binding loops; other site
440085010517	ABC-ATPase subunit interface; other site
440085010518	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
440085010519	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
440085010520	Secretin and TonB N terminus short domain; Region: STN; smart00965
440085010521	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085010522	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085010523	N-terminal plug; other site
440085010524	ligand-binding site [chemical binding]; other site
440085010525	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
440085010526	FecR protein; Region: FecR; pfam04773
440085010527	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
440085010528	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085010529	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085010530	DNA binding residues [nucleotide binding]
440085010531	IucA / IucC family; Region: IucA_IucC; pfam04183
440085010532	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
440085010533	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
440085010534	IucA / IucC family; Region: IucA_IucC; pfam04183
440085010535	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
440085010536	acyl-CoA synthetase; Validated; Region: PRK08308
440085010537	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085010538	acyl-activating enzyme (AAE) consensus motif; other site
440085010539	AMP binding site [chemical binding]; other site
440085010540	active site
440085010541	CoA binding site [chemical binding]; other site
440085010542	acyl carrier protein; Provisional; Region: PRK07639
440085010543	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
440085010544	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085010545	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
440085010546	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
440085010547	putative acetyltransferase YhhY; Provisional; Region: PRK10140
440085010548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085010549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
440085010550	Coenzyme A binding pocket [chemical binding]; other site
440085010551	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
440085010552	TetR family transcriptional regulator; Provisional; Region: PRK14996
440085010553	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
440085010554	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
440085010555	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
440085010556	Membrane fusogenic activity; Region: BMFP; pfam04380
440085010557	osmolarity response regulator; Provisional; Region: ompR; PRK09468
440085010558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010559	active site
440085010560	phosphorylation site [posttranslational modification]
440085010561	intermolecular recognition site; other site
440085010562	dimerization interface [polypeptide binding]; other site
440085010563	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085010564	DNA binding site [nucleotide binding]
440085010565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085010566	dimer interface [polypeptide binding]; other site
440085010567	phosphorylation site [posttranslational modification]
440085010568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085010569	ATP binding site [chemical binding]; other site
440085010570	Mg2+ binding site [ion binding]; other site
440085010571	G-X-G motif; other site
440085010572	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085010573	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085010574	metal binding site [ion binding]; metal-binding site
440085010575	active site
440085010576	I-site; other site
440085010577	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
440085010578	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085010579	putative C-terminal domain interface [polypeptide binding]; other site
440085010580	putative GSH binding site (G-site) [chemical binding]; other site
440085010581	putative dimer interface [polypeptide binding]; other site
440085010582	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
440085010583	putative N-terminal domain interface [polypeptide binding]; other site
440085010584	putative substrate binding pocket (H-site) [chemical binding]; other site
440085010585	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
440085010586	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
440085010587	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
440085010588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010589	active site
440085010590	phosphorylation site [posttranslational modification]
440085010591	intermolecular recognition site; other site
440085010592	dimerization interface [polypeptide binding]; other site
440085010593	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
440085010594	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
440085010595	putative active site [active]
440085010596	putative dimer interface [polypeptide binding]; other site
440085010597	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
440085010598	hypothetical protein; Provisional; Region: PRK10621
440085010599	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
440085010600	putative active site [active]
440085010601	putative catalytic site [active]
440085010602	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
440085010603	putative active site [active]
440085010604	putative catalytic site [active]
440085010605	YGGT family; Region: YGGT; pfam02325
440085010606	HD domain; Region: HD_4; pfam13328
440085010607	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
440085010608	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
440085010609	RNA/DNA hybrid binding site [nucleotide binding]; other site
440085010610	active site
440085010611	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
440085010612	N-acetyl-D-glucosamine binding site [chemical binding]; other site
440085010613	catalytic residue [active]
440085010614	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
440085010615	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085010616	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
440085010617	catalytic residues [active]
440085010618	catalytic nucleophile [active]
440085010619	Presynaptic Site I dimer interface [polypeptide binding]; other site
440085010620	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
440085010621	Synaptic Flat tetramer interface [polypeptide binding]; other site
440085010622	Synaptic Site I dimer interface [polypeptide binding]; other site
440085010623	DNA binding site [nucleotide binding]
440085010624	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085010625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
440085010626	active site
440085010627	intermolecular recognition site; other site
440085010628	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
440085010629	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085010630	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085010631	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085010632	active site
440085010633	DNA binding site [nucleotide binding]
440085010634	Int/Topo IB signature motif; other site
440085010635	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085010636	active site
440085010637	DNA binding site [nucleotide binding]
440085010638	Int/Topo IB signature motif; other site
440085010639	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
440085010640	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
440085010641	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
440085010642	Sulfate transporter family; Region: Sulfate_transp; pfam00916
440085010643	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
440085010644	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085010645	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085010646	NAD binding site [chemical binding]; other site
440085010647	catalytic Zn binding site [ion binding]; other site
440085010648	structural Zn binding site [ion binding]; other site
440085010649	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
440085010650	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
440085010651	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085010652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085010653	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085010654	putative active site [active]
440085010655	heme pocket [chemical binding]; other site
440085010656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085010657	dimer interface [polypeptide binding]; other site
440085010658	phosphorylation site [posttranslational modification]
440085010659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085010660	ATP binding site [chemical binding]; other site
440085010661	Mg2+ binding site [ion binding]; other site
440085010662	G-X-G motif; other site
440085010663	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085010664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085010665	active site
440085010666	phosphorylation site [posttranslational modification]
440085010667	intermolecular recognition site; other site
440085010668	dimerization interface [polypeptide binding]; other site
440085010669	short chain dehydrogenase; Provisional; Region: PRK06179
440085010670	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
440085010671	NADP binding site [chemical binding]; other site
440085010672	active site
440085010673	steroid binding site; other site
440085010674	Transcriptional regulators [Transcription]; Region: MarR; COG1846
440085010675	MarR family; Region: MarR_2; pfam12802
440085010676	DoxX-like family; Region: DoxX_2; pfam13564
440085010677	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
440085010678	putative efflux protein, MATE family; Region: matE; TIGR00797
440085010679	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
440085010680	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085010681	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085010682	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085010683	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
440085010684	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
440085010685	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
440085010686	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
440085010687	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
440085010688	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085010689	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
440085010690	TAP-like protein; Region: Abhydrolase_4; pfam08386
440085010691	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085010692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085010693	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085010694	dimerization interface [polypeptide binding]; other site
440085010695	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
440085010696	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085010697	GAF domain; Region: GAF; pfam01590
440085010698	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085010699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085010700	non-specific DNA binding site [nucleotide binding]; other site
440085010701	salt bridge; other site
440085010702	sequence-specific DNA binding site [nucleotide binding]; other site
440085010703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085010704	PAS domain; Region: PAS_9; pfam13426
440085010705	putative active site [active]
440085010706	heme pocket [chemical binding]; other site
440085010707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085010708	PAS domain; Region: PAS_9; pfam13426
440085010709	putative active site [active]
440085010710	heme pocket [chemical binding]; other site
440085010711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085010712	PAS domain; Region: PAS_9; pfam13426
440085010713	putative active site [active]
440085010714	heme pocket [chemical binding]; other site
440085010715	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085010716	dimer interface [polypeptide binding]; other site
440085010717	putative CheW interface [polypeptide binding]; other site
440085010718	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085010719	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085010720	protein binding site [polypeptide binding]; other site
440085010721	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085010722	protein binding site [polypeptide binding]; other site
440085010723	acid-resistance protein; Provisional; Region: PRK10208
440085010724	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
440085010725	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
440085010726	Cl- selectivity filter; other site
440085010727	Cl- binding residues [ion binding]; other site
440085010728	pore gating glutamate residue; other site
440085010729	dimer interface [polypeptide binding]; other site
440085010730	H+/Cl- coupling transport residue; other site
440085010731	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
440085010732	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085010733	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085010734	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
440085010735	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
440085010736	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
440085010737	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
440085010738	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085010739	dimerization interface [polypeptide binding]; other site
440085010740	putative DNA binding site [nucleotide binding]; other site
440085010741	putative Zn2+ binding site [ion binding]; other site
440085010742	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
440085010743	peroxiredoxin; Provisional; Region: PRK13189
440085010744	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085010745	Putative phosphatase (DUF442); Region: DUF442; cl17385
440085010746	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
440085010747	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085010748	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
440085010749	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
440085010750	putative metal binding site [ion binding]; other site
440085010751	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
440085010752	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
440085010753	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
440085010754	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
440085010755	ABC-ATPase subunit  interface; other site
440085010756	dimer interface [polypeptide binding]; other site
440085010757	putative PBP binding regions; other site
440085010758	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
440085010759	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
440085010760	Walker A/P-loop; other site
440085010761	ATP binding site [chemical binding]; other site
440085010762	Q-loop/lid; other site
440085010763	ABC transporter signature motif; other site
440085010764	Walker B; other site
440085010765	D-loop; other site
440085010766	H-loop/switch region; other site
440085010767	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
440085010768	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
440085010769	Moco binding site; other site
440085010770	metal coordination site [ion binding]; other site
440085010771	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
440085010772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085010773	S-adenosylmethionine binding site [chemical binding]; other site
440085010774	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085010775	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085010776	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085010777	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085010778	active site
440085010779	catalytic tetrad [active]
440085010780	Isochorismatase family; Region: Isochorismatase; pfam00857
440085010781	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
440085010782	catalytic triad [active]
440085010783	conserved cis-peptide bond; other site
440085010784	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085010785	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085010786	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085010787	TLC ATP/ADP transporter; Region: TLC; cl03940
440085010788	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
440085010789	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
440085010790	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085010791	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085010792	active site
440085010793	catalytic tetrad [active]
440085010794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085010795	S-adenosylmethionine binding site [chemical binding]; other site
440085010796	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
440085010797	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085010798	RNA binding surface [nucleotide binding]; other site
440085010799	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
440085010800	active site
440085010801	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
440085010802	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085010803	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085010804	dimerization interface [polypeptide binding]; other site
440085010805	putative DNA binding site [nucleotide binding]; other site
440085010806	putative Zn2+ binding site [ion binding]; other site
440085010807	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
440085010808	ArsC family; Region: ArsC; pfam03960
440085010809	catalytic residues [active]
440085010810	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
440085010811	arsenical-resistance protein; Region: acr3; TIGR00832
440085010812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085010813	PAS domain; Region: PAS_9; pfam13426
440085010814	putative active site [active]
440085010815	heme pocket [chemical binding]; other site
440085010816	PAS fold; Region: PAS_7; pfam12860
440085010817	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085010818	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085010819	metal binding site [ion binding]; metal-binding site
440085010820	active site
440085010821	I-site; other site
440085010822	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085010823	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
440085010824	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
440085010825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085010826	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
440085010827	NAD(P) binding site [chemical binding]; other site
440085010828	active site
440085010829	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
440085010830	nucleoside/Zn binding site; other site
440085010831	dimer interface [polypeptide binding]; other site
440085010832	catalytic motif [active]
440085010833	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
440085010834	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
440085010835	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
440085010836	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
440085010837	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
440085010838	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
440085010839	generic binding surface II; other site
440085010840	generic binding surface I; other site
440085010841	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
440085010842	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
440085010843	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
440085010844	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085010845	active site
440085010846	transcription elongation factor regulatory protein; Validated; Region: PRK06342
440085010847	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085010848	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
440085010849	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
440085010850	NADP binding site [chemical binding]; other site
440085010851	dimer interface [polypeptide binding]; other site
440085010852	Ferredoxin [Energy production and conversion]; Region: COG1146
440085010853	4Fe-4S binding domain; Region: Fer4; pfam00037
440085010854	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
440085010855	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
440085010856	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
440085010857	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085010858	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085010859	DNA binding residues [nucleotide binding]
440085010860	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085010861	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
440085010862	catalytic residues [active]
440085010863	catalytic nucleophile [active]
440085010864	Recombinase; Region: Recombinase; pfam07508
440085010865	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
440085010866	Protein of unknown function (DUF971); Region: DUF971; pfam06155
440085010867	putative oxidoreductase; Provisional; Region: PRK08275
440085010868	L-aspartate oxidase; Provisional; Region: PRK06175
440085010869	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
440085010870	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
440085010871	HEAT repeats; Region: HEAT_2; pfam13646
440085010872	HEAT repeats; Region: HEAT_2; pfam13646
440085010873	HEAT repeats; Region: HEAT_2; pfam13646
440085010874	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085010875	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085010876	ligand binding site [chemical binding]; other site
440085010877	flexible hinge region; other site
440085010878	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085010879	putative switch regulator; other site
440085010880	non-specific DNA interactions [nucleotide binding]; other site
440085010881	DNA binding site [nucleotide binding]
440085010882	sequence specific DNA binding site [nucleotide binding]; other site
440085010883	putative cAMP binding site [chemical binding]; other site
440085010884	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085010885	NMT1-like family; Region: NMT1_2; pfam13379
440085010886	substrate binding pocket [chemical binding]; other site
440085010887	membrane-bound complex binding site; other site
440085010888	hinge residues; other site
440085010889	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085010890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085010891	dimer interface [polypeptide binding]; other site
440085010892	conserved gate region; other site
440085010893	putative PBP binding loops; other site
440085010894	ABC-ATPase subunit interface; other site
440085010895	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085010896	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085010897	Walker A/P-loop; other site
440085010898	ATP binding site [chemical binding]; other site
440085010899	Q-loop/lid; other site
440085010900	ABC transporter signature motif; other site
440085010901	Walker B; other site
440085010902	D-loop; other site
440085010903	H-loop/switch region; other site
440085010904	Ferredoxin [Energy production and conversion]; Region: COG1146
440085010905	4Fe-4S binding domain; Region: Fer4; pfam00037
440085010906	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
440085010907	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
440085010908	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
440085010909	FAD binding pocket [chemical binding]; other site
440085010910	FAD binding motif [chemical binding]; other site
440085010911	phosphate binding motif [ion binding]; other site
440085010912	beta-alpha-beta structure motif; other site
440085010913	NAD binding pocket [chemical binding]; other site
440085010914	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
440085010915	CoA binding domain; Region: CoA_binding; smart00881
440085010916	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
440085010917	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
440085010918	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
440085010919	CoA-ligase; Region: Ligase_CoA; pfam00549
440085010920	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
440085010921	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
440085010922	putative catalytic cysteine [active]
440085010923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085010924	D-galactonate transporter; Region: 2A0114; TIGR00893
440085010925	putative substrate translocation pore; other site
440085010926	choline dehydrogenase; Validated; Region: PRK02106
440085010927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085010928	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
440085010929	metabolite-proton symporter; Region: 2A0106; TIGR00883
440085010930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085010931	putative substrate translocation pore; other site
440085010932	Predicted membrane protein [Function unknown]; Region: COG2855
440085010933	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
440085010934	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085010935	PYR/PP interface [polypeptide binding]; other site
440085010936	dimer interface [polypeptide binding]; other site
440085010937	TPP binding site [chemical binding]; other site
440085010938	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085010939	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
440085010940	TPP-binding site; other site
440085010941	Transcriptional regulator [Transcription]; Region: IclR; COG1414
440085010942	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
440085010943	Bacterial transcriptional regulator; Region: IclR; pfam01614
440085010944	propionate/acetate kinase; Provisional; Region: PRK12379
440085010945	Acetokinase family; Region: Acetate_kinase; cl17229
440085010946	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
440085010947	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
440085010948	Moco binding site; other site
440085010949	metal coordination site [ion binding]; other site
440085010950	dimerization interface [polypeptide binding]; other site
440085010951	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
440085010952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
440085010953	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085010954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085010955	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085010956	dimerization interface [polypeptide binding]; other site
440085010957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010958	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
440085010959	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
440085010960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085010961	S-adenosylmethionine binding site [chemical binding]; other site
440085010962	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
440085010963	Bacterial sugar transferase; Region: Bac_transf; pfam02397
440085010964	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
440085010965	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
440085010966	Chain length determinant protein; Region: Wzz; cl15801
440085010967	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
440085010968	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010970	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
440085010971	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085010972	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
440085010973	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
440085010974	Glucose inhibited division protein A; Region: GIDA; pfam01134
440085010975	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
440085010976	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
440085010977	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085010978	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085010979	protein binding site [polypeptide binding]; other site
440085010980	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
440085010981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085010982	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085010983	DNA binding residues [nucleotide binding]
440085010984	Anti-sigma-K factor rskA; Region: RskA; pfam10099
440085010985	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085010986	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
440085010987	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
440085010988	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
440085010989	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
440085010990	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085010991	putative CheW interface [polypeptide binding]; other site
440085010992	Nitrate and nitrite sensing; Region: NIT; pfam08376
440085010993	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
440085010994	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085010995	dimer interface [polypeptide binding]; other site
440085010996	putative CheW interface [polypeptide binding]; other site
440085010997	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085010998	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085010999	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085011000	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
440085011001	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
440085011002	Response regulator receiver domain; Region: Response_reg; pfam00072
440085011003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
440085011004	active site
440085011005	phosphorylation site [posttranslational modification]
440085011006	intermolecular recognition site; other site
440085011007	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085011008	GAF domain; Region: GAF; pfam01590
440085011009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011010	PAS fold; Region: PAS_3; pfam08447
440085011011	putative active site [active]
440085011012	heme pocket [chemical binding]; other site
440085011013	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011014	PAS fold; Region: PAS_3; pfam08447
440085011015	putative active site [active]
440085011016	heme pocket [chemical binding]; other site
440085011017	PAS domain S-box; Region: sensory_box; TIGR00229
440085011018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011019	putative active site [active]
440085011020	heme pocket [chemical binding]; other site
440085011021	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085011022	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085011023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085011024	HWE histidine kinase; Region: HWE_HK; pfam07536
440085011025	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085011026	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
440085011027	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085011028	non-specific DNA interactions [nucleotide binding]; other site
440085011029	DNA binding site [nucleotide binding]
440085011030	sequence specific DNA binding site [nucleotide binding]; other site
440085011031	putative cAMP binding site [chemical binding]; other site
440085011032	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
440085011033	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
440085011034	active site
440085011035	Protein of unknown function, DUF488; Region: DUF488; pfam04343
440085011036	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
440085011037	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
440085011038	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
440085011039	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
440085011040	NADP binding site [chemical binding]; other site
440085011041	dimer interface [polypeptide binding]; other site
440085011042	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
440085011043	Isochorismatase family; Region: Isochorismatase; pfam00857
440085011044	catalytic triad [active]
440085011045	metal binding site [ion binding]; metal-binding site
440085011046	conserved cis-peptide bond; other site
440085011047	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
440085011048	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
440085011049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085011050	catalytic residue [active]
440085011051	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
440085011052	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
440085011053	glutamine binding [chemical binding]; other site
440085011054	catalytic triad [active]
440085011055	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
440085011056	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
440085011057	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
440085011058	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
440085011059	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
440085011060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085011061	FeS/SAM binding site; other site
440085011062	Predicted membrane protein [Function unknown]; Region: COG4270
440085011063	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
440085011064	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
440085011065	homodimer interface [polypeptide binding]; other site
440085011066	metal binding site [ion binding]; metal-binding site
440085011067	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
440085011068	homodimer interface [polypeptide binding]; other site
440085011069	active site
440085011070	putative chemical substrate binding site [chemical binding]; other site
440085011071	metal binding site [ion binding]; metal-binding site
440085011072	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
440085011073	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
440085011074	active site
440085011075	nucleophile elbow; other site
440085011076	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
440085011077	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
440085011078	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085011079	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085011080	metal binding site [ion binding]; metal-binding site
440085011081	active site
440085011082	I-site; other site
440085011083	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085011084	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085011085	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085011086	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085011087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085011088	Zn2+ binding site [ion binding]; other site
440085011089	Mg2+ binding site [ion binding]; other site
440085011090	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
440085011091	oligomer interface [polypeptide binding]; other site
440085011092	putative active site [active]
440085011093	Mn binding site [ion binding]; other site
440085011094	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
440085011095	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
440085011096	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
440085011097	Flavoprotein; Region: Flavoprotein; pfam02441
440085011098	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
440085011099	ABC1 family; Region: ABC1; cl17513
440085011100	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
440085011101	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
440085011102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085011103	S-adenosylmethionine binding site [chemical binding]; other site
440085011104	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
440085011105	folate binding site [chemical binding]; other site
440085011106	NADP+ binding site [chemical binding]; other site
440085011107	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
440085011108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085011109	NAD(P) binding site [chemical binding]; other site
440085011110	active site
440085011111	amidophosphoribosyltransferase; Provisional; Region: PRK09123
440085011112	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
440085011113	active site
440085011114	tetramer interface [polypeptide binding]; other site
440085011115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
440085011116	active site
440085011117	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
440085011118	Colicin V production protein; Region: Colicin_V; pfam02674
440085011119	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
440085011120	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
440085011121	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
440085011122	Cu(I) binding site [ion binding]; other site
440085011123	DNA repair protein RadA; Provisional; Region: PRK11823
440085011124	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
440085011125	Walker A motif/ATP binding site; other site
440085011126	ATP binding site [chemical binding]; other site
440085011127	Walker B motif; other site
440085011128	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
440085011129	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
440085011130	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
440085011131	active site
440085011132	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
440085011133	dimer interface [polypeptide binding]; other site
440085011134	substrate binding site [chemical binding]; other site
440085011135	catalytic residues [active]
440085011136	replicative DNA helicase; Provisional; Region: PRK09165
440085011137	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
440085011138	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
440085011139	Walker A motif; other site
440085011140	ATP binding site [chemical binding]; other site
440085011141	Walker B motif; other site
440085011142	DNA binding loops [nucleotide binding]
440085011143	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
440085011144	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
440085011145	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
440085011146	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
440085011147	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
440085011148	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
440085011149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085011150	Coenzyme A binding pocket [chemical binding]; other site
440085011151	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
440085011152	pentamer interface [polypeptide binding]; other site
440085011153	dodecaamer interface [polypeptide binding]; other site
440085011154	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085011155	DNA-binding site [nucleotide binding]; DNA binding site
440085011156	RNA-binding motif; other site
440085011157	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
440085011158	active site
440085011159	catalytic residues [active]
440085011160	metal binding site [ion binding]; metal-binding site
440085011161	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085011162	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085011163	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
440085011164	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
440085011165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085011166	Coenzyme A binding pocket [chemical binding]; other site
440085011167	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
440085011168	fructuronate transporter; Provisional; Region: PRK10034; cl15264
440085011169	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
440085011170	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
440085011171	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
440085011172	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
440085011173	NAD(P) binding site [chemical binding]; other site
440085011174	active site
440085011175	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
440085011176	Aspartase; Region: Aspartase; cd01357
440085011177	active sites [active]
440085011178	tetramer interface [polypeptide binding]; other site
440085011179	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
440085011180	Porin subfamily; Region: Porin_2; pfam02530
440085011181	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
440085011182	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085011183	substrate binding pocket [chemical binding]; other site
440085011184	membrane-bound complex binding site; other site
440085011185	hinge residues; other site
440085011186	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
440085011187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085011188	dimer interface [polypeptide binding]; other site
440085011189	conserved gate region; other site
440085011190	putative PBP binding loops; other site
440085011191	ABC-ATPase subunit interface; other site
440085011192	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
440085011193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085011194	dimer interface [polypeptide binding]; other site
440085011195	conserved gate region; other site
440085011196	putative PBP binding loops; other site
440085011197	ABC-ATPase subunit interface; other site
440085011198	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
440085011199	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
440085011200	Walker A/P-loop; other site
440085011201	ATP binding site [chemical binding]; other site
440085011202	Q-loop/lid; other site
440085011203	ABC transporter signature motif; other site
440085011204	Walker B; other site
440085011205	D-loop; other site
440085011206	H-loop/switch region; other site
440085011207	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085011208	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085011209	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
440085011210	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
440085011211	transmembrane helices; other site
440085011212	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
440085011213	nudix motif; other site
440085011214	SPFH domain / Band 7 family; Region: Band_7; pfam01145
440085011215	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
440085011216	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
440085011217	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
440085011218	acyl-activating enzyme (AAE) consensus motif; other site
440085011219	AMP binding site [chemical binding]; other site
440085011220	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
440085011221	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
440085011222	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
440085011223	putative trimer interface [polypeptide binding]; other site
440085011224	putative CoA binding site [chemical binding]; other site
440085011225	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
440085011226	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
440085011227	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
440085011228	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
440085011229	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085011230	catalytic residue [active]
440085011231	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
440085011232	putative ABC transporter; Region: ycf24; CHL00085
440085011233	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
440085011234	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
440085011235	Walker A/P-loop; other site
440085011236	ATP binding site [chemical binding]; other site
440085011237	Q-loop/lid; other site
440085011238	ABC transporter signature motif; other site
440085011239	Walker B; other site
440085011240	D-loop; other site
440085011241	H-loop/switch region; other site
440085011242	FeS assembly protein SufD; Region: sufD; TIGR01981
440085011243	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
440085011244	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
440085011245	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
440085011246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085011247	catalytic residue [active]
440085011248	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
440085011249	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
440085011250	putative active site [active]
440085011251	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
440085011252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085011253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085011254	metal binding site [ion binding]; metal-binding site
440085011255	active site
440085011256	I-site; other site
440085011257	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
440085011258	DEAD-like helicases superfamily; Region: DEXDc; smart00487
440085011259	ATP binding site [chemical binding]; other site
440085011260	Mg++ binding site [ion binding]; other site
440085011261	motif III; other site
440085011262	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085011263	nucleotide binding region [chemical binding]; other site
440085011264	ATP-binding site [chemical binding]; other site
440085011265	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
440085011266	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
440085011267	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
440085011268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
440085011269	motif II; other site
440085011270	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
440085011271	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
440085011272	Walker A/P-loop; other site
440085011273	ATP binding site [chemical binding]; other site
440085011274	Q-loop/lid; other site
440085011275	ABC transporter signature motif; other site
440085011276	Walker B; other site
440085011277	D-loop; other site
440085011278	H-loop/switch region; other site
440085011279	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
440085011280	active site
440085011281	catalytic triad [active]
440085011282	oxyanion hole [active]
440085011283	switch loop; other site
440085011284	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
440085011285	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
440085011286	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
440085011287	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
440085011288	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
440085011289	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
440085011290	putative homodimer interface [polypeptide binding]; other site
440085011291	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
440085011292	heterodimer interface [polypeptide binding]; other site
440085011293	homodimer interface [polypeptide binding]; other site
440085011294	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
440085011295	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
440085011296	23S rRNA interface [nucleotide binding]; other site
440085011297	L7/L12 interface [polypeptide binding]; other site
440085011298	putative thiostrepton binding site; other site
440085011299	L25 interface [polypeptide binding]; other site
440085011300	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
440085011301	mRNA/rRNA interface [nucleotide binding]; other site
440085011302	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
440085011303	Cytochrome P450; Region: p450; cl12078
440085011304	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
440085011305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085011306	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
440085011307	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
440085011308	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
440085011309	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085011310	Probable Catalytic site; other site
440085011311	metal-binding site
440085011312	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
440085011313	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
440085011314	dimer interface [polypeptide binding]; other site
440085011315	anticodon binding site; other site
440085011316	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
440085011317	motif 1; other site
440085011318	dimer interface [polypeptide binding]; other site
440085011319	active site
440085011320	motif 2; other site
440085011321	GAD domain; Region: GAD; pfam02938
440085011322	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
440085011323	active site
440085011324	motif 3; other site
440085011325	biotin synthase; Region: bioB; TIGR00433
440085011326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
440085011327	FeS/SAM binding site; other site
440085011328	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
440085011329	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
440085011330	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
440085011331	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
440085011332	arogenate dehydrogenase; Region: PLN02256
440085011333	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
440085011334	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
440085011335	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085011336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011337	PAS domain; Region: PAS_9; pfam13426
440085011338	putative active site [active]
440085011339	heme pocket [chemical binding]; other site
440085011340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085011341	metal binding site [ion binding]; metal-binding site
440085011342	active site
440085011343	I-site; other site
440085011344	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085011345	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
440085011346	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
440085011347	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
440085011348	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
440085011349	23S rRNA interface [nucleotide binding]; other site
440085011350	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
440085011351	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
440085011352	L11 interface [polypeptide binding]; other site
440085011353	putative EF-Tu interaction site [polypeptide binding]; other site
440085011354	putative EF-G interaction site [polypeptide binding]; other site
440085011355	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
440085011356	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
440085011357	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
440085011358	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
440085011359	RPB11 interaction site [polypeptide binding]; other site
440085011360	RPB12 interaction site [polypeptide binding]; other site
440085011361	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
440085011362	RPB3 interaction site [polypeptide binding]; other site
440085011363	RPB1 interaction site [polypeptide binding]; other site
440085011364	RPB11 interaction site [polypeptide binding]; other site
440085011365	RPB10 interaction site [polypeptide binding]; other site
440085011366	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
440085011367	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
440085011368	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
440085011369	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
440085011370	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
440085011371	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
440085011372	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
440085011373	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
440085011374	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
440085011375	DNA binding site [nucleotide binding]
440085011376	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
440085011377	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
440085011378	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
440085011379	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
440085011380	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
440085011381	homotrimer interaction site [polypeptide binding]; other site
440085011382	putative active site [active]
440085011383	Predicted membrane protein [Function unknown]; Region: COG2261
440085011384	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
440085011385	NmrA-like family; Region: NmrA; pfam05368
440085011386	NADP binding site [chemical binding]; other site
440085011387	Predicted transcriptional regulators [Transcription]; Region: COG1733
440085011388	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
440085011389	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085011390	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
440085011391	putative C-terminal domain interface [polypeptide binding]; other site
440085011392	putative GSH binding site (G-site) [chemical binding]; other site
440085011393	putative dimer interface [polypeptide binding]; other site
440085011394	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
440085011395	dimer interface [polypeptide binding]; other site
440085011396	N-terminal domain interface [polypeptide binding]; other site
440085011397	putative substrate binding pocket (H-site) [chemical binding]; other site
440085011398	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
440085011399	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085011400	N-terminal plug; other site
440085011401	ligand-binding site [chemical binding]; other site
440085011402	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
440085011403	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
440085011404	RNase E interface [polypeptide binding]; other site
440085011405	trimer interface [polypeptide binding]; other site
440085011406	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
440085011407	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
440085011408	RNase E interface [polypeptide binding]; other site
440085011409	trimer interface [polypeptide binding]; other site
440085011410	active site
440085011411	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
440085011412	putative nucleic acid binding region [nucleotide binding]; other site
440085011413	G-X-X-G motif; other site
440085011414	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
440085011415	RNA binding site [nucleotide binding]; other site
440085011416	domain interface; other site
440085011417	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
440085011418	16S/18S rRNA binding site [nucleotide binding]; other site
440085011419	S13e-L30e interaction site [polypeptide binding]; other site
440085011420	25S rRNA binding site [nucleotide binding]; other site
440085011421	amino acid transporter; Region: 2A0306; TIGR00909
440085011422	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
440085011423	putative catalytic site [active]
440085011424	putative phosphate binding site [ion binding]; other site
440085011425	active site
440085011426	metal binding site A [ion binding]; metal-binding site
440085011427	DNA binding site [nucleotide binding]
440085011428	putative AP binding site [nucleotide binding]; other site
440085011429	putative metal binding site B [ion binding]; other site
440085011430	Sensors of blue-light using FAD; Region: BLUF; pfam04940
440085011431	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085011432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085011433	metal binding site [ion binding]; metal-binding site
440085011434	active site
440085011435	I-site; other site
440085011436	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085011437	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
440085011438	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
440085011439	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
440085011440	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
440085011441	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
440085011442	NAD synthetase; Reviewed; Region: nadE; PRK02628
440085011443	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
440085011444	multimer interface [polypeptide binding]; other site
440085011445	active site
440085011446	catalytic triad [active]
440085011447	protein interface 1 [polypeptide binding]; other site
440085011448	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
440085011449	homodimer interface [polypeptide binding]; other site
440085011450	NAD binding pocket [chemical binding]; other site
440085011451	ATP binding pocket [chemical binding]; other site
440085011452	Mg binding site [ion binding]; other site
440085011453	active-site loop [active]
440085011454	response regulator; Provisional; Region: PRK13435
440085011455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011456	active site
440085011457	phosphorylation site [posttranslational modification]
440085011458	intermolecular recognition site; other site
440085011459	dimerization interface [polypeptide binding]; other site
440085011460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011461	PAS domain; Region: PAS_9; pfam13426
440085011462	putative active site [active]
440085011463	heme pocket [chemical binding]; other site
440085011464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085011465	Histidine kinase; Region: HisKA_2; pfam07568
440085011466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011467	ATP binding site [chemical binding]; other site
440085011468	Mg2+ binding site [ion binding]; other site
440085011469	G-X-G motif; other site
440085011470	muropeptide transporter; Validated; Region: ampG; cl17669
440085011471	EcsC protein family; Region: EcsC; pfam12787
440085011472	NnrU protein; Region: NnrU; pfam07298
440085011473	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
440085011474	GTP-binding protein Der; Reviewed; Region: PRK00093
440085011475	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
440085011476	G1 box; other site
440085011477	GTP/Mg2+ binding site [chemical binding]; other site
440085011478	Switch I region; other site
440085011479	G2 box; other site
440085011480	Switch II region; other site
440085011481	G3 box; other site
440085011482	G4 box; other site
440085011483	G5 box; other site
440085011484	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
440085011485	G1 box; other site
440085011486	GTP/Mg2+ binding site [chemical binding]; other site
440085011487	Switch I region; other site
440085011488	G2 box; other site
440085011489	G3 box; other site
440085011490	Switch II region; other site
440085011491	G4 box; other site
440085011492	G5 box; other site
440085011493	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
440085011494	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
440085011495	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
440085011496	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
440085011497	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
440085011498	DNA binding site [nucleotide binding]
440085011499	catalytic residue [active]
440085011500	H2TH interface [polypeptide binding]; other site
440085011501	putative catalytic residues [active]
440085011502	turnover-facilitating residue; other site
440085011503	intercalation triad [nucleotide binding]; other site
440085011504	8OG recognition residue [nucleotide binding]; other site
440085011505	putative reading head residues; other site
440085011506	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
440085011507	Predicted transcriptional regulator [Transcription]; Region: COG1959
440085011508	Transcriptional regulator; Region: Rrf2; pfam02082
440085011509	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
440085011510	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
440085011511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085011512	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
440085011513	Beta-lactamase; Region: Beta-lactamase; pfam00144
440085011514	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
440085011515	PAS fold; Region: PAS_4; pfam08448
440085011516	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085011517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011518	putative active site [active]
440085011519	heme pocket [chemical binding]; other site
440085011520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085011521	dimer interface [polypeptide binding]; other site
440085011522	phosphorylation site [posttranslational modification]
440085011523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011524	ATP binding site [chemical binding]; other site
440085011525	Mg2+ binding site [ion binding]; other site
440085011526	G-X-G motif; other site
440085011527	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085011528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011529	active site
440085011530	phosphorylation site [posttranslational modification]
440085011531	intermolecular recognition site; other site
440085011532	dimerization interface [polypeptide binding]; other site
440085011533	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
440085011534	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085011535	GSH binding site (G-site) [chemical binding]; other site
440085011536	C-terminal domain interface [polypeptide binding]; other site
440085011537	dimer interface [polypeptide binding]; other site
440085011538	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
440085011539	dimer interface [polypeptide binding]; other site
440085011540	N-terminal domain interface [polypeptide binding]; other site
440085011541	substrate binding pocket (H-site) [chemical binding]; other site
440085011542	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
440085011543	excinuclease ABC subunit B; Provisional; Region: PRK05298
440085011544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085011545	ATP binding site [chemical binding]; other site
440085011546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085011547	nucleotide binding region [chemical binding]; other site
440085011548	ATP-binding site [chemical binding]; other site
440085011549	Ultra-violet resistance protein B; Region: UvrB; pfam12344
440085011550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085011551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085011552	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
440085011553	putative effector binding pocket; other site
440085011554	dimerization interface [polypeptide binding]; other site
440085011555	Predicted membrane protein [Function unknown]; Region: COG2259
440085011556	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
440085011557	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085011558	putative metal binding site [ion binding]; other site
440085011559	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
440085011560	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839
440085011561	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
440085011562	catalytic residue [active]
440085011563	putative FPP diphosphate  binding site; other site
440085011564	putative FPP binding hydrophobic cleft; other site
440085011565	dimer interface [polypeptide binding]; other site
440085011566	putative IPP diphosphate binding site; other site
440085011567	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
440085011568	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
440085011569	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
440085011570	glycerol kinase; Provisional; Region: glpK; PRK00047
440085011571	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
440085011572	N- and C-terminal domain interface [polypeptide binding]; other site
440085011573	active site
440085011574	MgATP binding site [chemical binding]; other site
440085011575	catalytic site [active]
440085011576	metal binding site [ion binding]; metal-binding site
440085011577	putative homotetramer interface [polypeptide binding]; other site
440085011578	glycerol binding site [chemical binding]; other site
440085011579	homodimer interface [polypeptide binding]; other site
440085011580	hypothetical protein; Provisional; Region: PRK06489
440085011581	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
440085011582	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085011583	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085011584	dimer interface [polypeptide binding]; other site
440085011585	putative CheW interface [polypeptide binding]; other site
440085011586	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
440085011587	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
440085011588	active site
440085011589	catalytic site [active]
440085011590	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
440085011591	homotrimer interaction site [polypeptide binding]; other site
440085011592	putative active site [active]
440085011593	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
440085011594	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
440085011595	putative active site [active]
440085011596	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085011597	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
440085011598	Walker A/P-loop; other site
440085011599	ATP binding site [chemical binding]; other site
440085011600	Q-loop/lid; other site
440085011601	ABC transporter signature motif; other site
440085011602	Walker B; other site
440085011603	D-loop; other site
440085011604	H-loop/switch region; other site
440085011605	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
440085011606	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
440085011607	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085011608	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
440085011609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085011610	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
440085011611	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
440085011612	inhibitor-cofactor binding pocket; inhibition site
440085011613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085011614	catalytic residue [active]
440085011615	ornithine carbamoyltransferase; Provisional; Region: PRK00779
440085011616	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
440085011617	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
440085011618	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
440085011619	putative hydrophobic ligand binding site [chemical binding]; other site
440085011620	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
440085011621	putative dimer interface [polypeptide binding]; other site
440085011622	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085011623	short chain dehydrogenase; Provisional; Region: PRK06523
440085011624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085011625	NAD(P) binding site [chemical binding]; other site
440085011626	active site
440085011627	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
440085011628	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085011629	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085011630	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
440085011631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085011632	putative active site [active]
440085011633	heme pocket [chemical binding]; other site
440085011634	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
440085011635	GAF domain; Region: GAF; pfam01590
440085011636	Phytochrome region; Region: PHY; pfam00360
440085011637	Histidine kinase; Region: HisKA_2; pfam07568
440085011638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011639	ATP binding site [chemical binding]; other site
440085011640	Mg2+ binding site [ion binding]; other site
440085011641	G-X-G motif; other site
440085011642	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
440085011643	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
440085011644	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
440085011645	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
440085011646	PAP2 superfamily; Region: PAP2_3; pfam14378
440085011647	active site
440085011648	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085011649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085011650	Walker A motif; other site
440085011651	ATP binding site [chemical binding]; other site
440085011652	Walker B motif; other site
440085011653	arginine finger; other site
440085011654	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085011655	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
440085011656	flagellar assembly protein H; Validated; Region: fliH; PRK06032
440085011657	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
440085011658	FliG C-terminal domain; Region: FliG_C; pfam01706
440085011659	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
440085011660	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
440085011661	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
440085011662	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
440085011663	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
440085011664	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
440085011665	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
440085011666	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
440085011667	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
440085011668	Ligand Binding Site [chemical binding]; other site
440085011669	Methyltransferase domain; Region: Methyltransf_31; pfam13847
440085011670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085011671	S-adenosylmethionine binding site [chemical binding]; other site
440085011672	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
440085011673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085011674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011675	ATP binding site [chemical binding]; other site
440085011676	Mg2+ binding site [ion binding]; other site
440085011677	G-X-G motif; other site
440085011678	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
440085011679	active site clefts [active]
440085011680	zinc binding site [ion binding]; other site
440085011681	dimer interface [polypeptide binding]; other site
440085011682	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
440085011683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085011684	putative substrate translocation pore; other site
440085011685	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
440085011686	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085011687	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085011688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085011689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085011690	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
440085011691	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
440085011692	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085011693	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085011694	active site
440085011695	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
440085011696	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
440085011697	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
440085011698	PAS domain; Region: PAS; smart00091
440085011699	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085011700	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085011701	dimer interface [polypeptide binding]; other site
440085011702	phosphorylation site [posttranslational modification]
440085011703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011704	ATP binding site [chemical binding]; other site
440085011705	Mg2+ binding site [ion binding]; other site
440085011706	G-X-G motif; other site
440085011707	Response regulator receiver domain; Region: Response_reg; pfam00072
440085011708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011709	active site
440085011710	phosphorylation site [posttranslational modification]
440085011711	intermolecular recognition site; other site
440085011712	dimerization interface [polypeptide binding]; other site
440085011713	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
440085011714	tetramer interface [polypeptide binding]; other site
440085011715	dimer interface [polypeptide binding]; other site
440085011716	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
440085011717	tetramer interface [polypeptide binding]; other site
440085011718	dimer interface [polypeptide binding]; other site
440085011719	circadian clock protein KaiC; Reviewed; Region: PRK09302
440085011720	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085011721	Walker A motif; other site
440085011722	ATP binding site [chemical binding]; other site
440085011723	Walker B motif; other site
440085011724	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085011725	Walker A motif; other site
440085011726	ATP binding site [chemical binding]; other site
440085011727	Walker B motif; other site
440085011728	Response regulator receiver domain; Region: Response_reg; pfam00072
440085011729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011730	active site
440085011731	phosphorylation site [posttranslational modification]
440085011732	intermolecular recognition site; other site
440085011733	dimerization interface [polypeptide binding]; other site
440085011734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085011735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011736	ATP binding site [chemical binding]; other site
440085011737	Mg2+ binding site [ion binding]; other site
440085011738	G-X-G motif; other site
440085011739	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085011740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011741	active site
440085011742	phosphorylation site [posttranslational modification]
440085011743	intermolecular recognition site; other site
440085011744	dimerization interface [polypeptide binding]; other site
440085011745	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085011746	DNA binding site [nucleotide binding]
440085011747	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
440085011748	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
440085011749	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
440085011750	Catalytic site; other site
440085011751	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
440085011752	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
440085011753	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
440085011754	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
440085011755	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
440085011756	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085011757	N-terminal plug; other site
440085011758	ligand-binding site [chemical binding]; other site
440085011759	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
440085011760	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
440085011761	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
440085011762	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
440085011763	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
440085011764	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
440085011765	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
440085011766	active site
440085011767	substrate binding site [chemical binding]; other site
440085011768	metal binding site [ion binding]; metal-binding site
440085011769	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
440085011770	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
440085011771	Right handed beta helix region; Region: Beta_helix; pfam13229
440085011772	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
440085011773	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
440085011774	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
440085011775	Bacterial sugar transferase; Region: Bac_transf; pfam02397
440085011776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085011777	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085011778	NAD(P) binding site [chemical binding]; other site
440085011779	active site
440085011780	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
440085011781	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
440085011782	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
440085011783	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085011784	NAD binding site [chemical binding]; other site
440085011785	putative substrate binding site 2 [chemical binding]; other site
440085011786	putative substrate binding site 1 [chemical binding]; other site
440085011787	active site
440085011788	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
440085011789	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
440085011790	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
440085011791	Substrate binding site; other site
440085011792	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
440085011793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085011794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011795	active site
440085011796	phosphorylation site [posttranslational modification]
440085011797	intermolecular recognition site; other site
440085011798	dimerization interface [polypeptide binding]; other site
440085011799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085011800	DNA binding residues [nucleotide binding]
440085011801	dimerization interface [polypeptide binding]; other site
440085011802	Uncharacterized conserved protein [Function unknown]; Region: COG3391
440085011803	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085011804	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085011805	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085011806	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085011807	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
440085011808	putative hydrophobic ligand binding site [chemical binding]; other site
440085011809	protein interface [polypeptide binding]; other site
440085011810	gate; other site
440085011811	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
440085011812	metal ion-dependent adhesion site (MIDAS); other site
440085011813	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
440085011814	metal ion-dependent adhesion site (MIDAS); other site
440085011815	Protein of unknown function DUF58; Region: DUF58; pfam01882
440085011816	MoxR-like ATPases [General function prediction only]; Region: COG0714
440085011817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085011818	Walker A motif; other site
440085011819	ATP binding site [chemical binding]; other site
440085011820	Walker B motif; other site
440085011821	arginine finger; other site
440085011822	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
440085011823	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
440085011824	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
440085011825	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
440085011826	substrate binding pocket [chemical binding]; other site
440085011827	membrane-bound complex binding site; other site
440085011828	hinge residues; other site
440085011829	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
440085011830	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
440085011831	Trp docking motif [polypeptide binding]; other site
440085011832	dimer interface [polypeptide binding]; other site
440085011833	active site
440085011834	small subunit binding site [polypeptide binding]; other site
440085011835	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085011836	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
440085011837	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085011838	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
440085011839	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
440085011840	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
440085011841	Substrate binding site; other site
440085011842	Mg++ binding site; other site
440085011843	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
440085011844	putative trimer interface [polypeptide binding]; other site
440085011845	putative CoA binding site [chemical binding]; other site
440085011846	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
440085011847	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
440085011848	glutaminase active site [active]
440085011849	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
440085011850	dimer interface [polypeptide binding]; other site
440085011851	active site
440085011852	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
440085011853	dimer interface [polypeptide binding]; other site
440085011854	active site
440085011855	Domain of unknown function (DUF336); Region: DUF336; pfam03928
440085011856	Uncharacterized conserved protein [Function unknown]; Region: COG2928
440085011857	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
440085011858	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
440085011859	generic binding surface II; other site
440085011860	ssDNA binding site; other site
440085011861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085011862	ATP binding site [chemical binding]; other site
440085011863	putative Mg++ binding site [ion binding]; other site
440085011864	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085011865	nucleotide binding region [chemical binding]; other site
440085011866	ATP-binding site [chemical binding]; other site
440085011867	Uncharacterized conserved protein [Function unknown]; Region: COG2938
440085011868	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
440085011869	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
440085011870	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085011871	ATP binding site [chemical binding]; other site
440085011872	putative Mg++ binding site [ion binding]; other site
440085011873	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085011874	nucleotide binding region [chemical binding]; other site
440085011875	ATP-binding site [chemical binding]; other site
440085011876	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
440085011877	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
440085011878	DNA-binding site [nucleotide binding]; DNA binding site
440085011879	RNA-binding motif; other site
440085011880	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
440085011881	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085011882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
440085011883	dimer interface [polypeptide binding]; other site
440085011884	phosphorylation site [posttranslational modification]
440085011885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011886	ATP binding site [chemical binding]; other site
440085011887	Mg2+ binding site [ion binding]; other site
440085011888	G-X-G motif; other site
440085011889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085011890	active site
440085011891	phosphorylation site [posttranslational modification]
440085011892	intermolecular recognition site; other site
440085011893	acyl-CoA synthetase; Validated; Region: PRK08162
440085011894	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
440085011895	acyl-activating enzyme (AAE) consensus motif; other site
440085011896	putative active site [active]
440085011897	AMP binding site [chemical binding]; other site
440085011898	putative CoA binding site [chemical binding]; other site
440085011899	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
440085011900	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
440085011901	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
440085011902	Ligand binding site; other site
440085011903	Putative Catalytic site; other site
440085011904	DXD motif; other site
440085011905	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
440085011906	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
440085011907	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
440085011908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
440085011909	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
440085011910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085011911	NAD(P) binding site [chemical binding]; other site
440085011912	active site
440085011913	hypothetical protein; Validated; Region: PRK00029
440085011914	Uncharacterized conserved protein [Function unknown]; Region: COG0397
440085011915	Protein of unknown function (DUF433); Region: DUF433; pfam04255
440085011916	EamA-like transporter family; Region: EamA; pfam00892
440085011917	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
440085011918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085011919	Histidine kinase; Region: HisKA_2; pfam07568
440085011920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085011921	ATP binding site [chemical binding]; other site
440085011922	Mg2+ binding site [ion binding]; other site
440085011923	G-X-G motif; other site
440085011924	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
440085011925	active site
440085011926	oxyanion hole [active]
440085011927	catalytic triad [active]
440085011928	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
440085011929	heme-binding site [chemical binding]; other site
440085011930	putative hydrolase; Provisional; Region: PRK02113
440085011931	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
440085011932	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
440085011933	active site
440085011934	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
440085011935	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
440085011936	active site
440085011937	HIGH motif; other site
440085011938	KMSKS motif; other site
440085011939	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
440085011940	tRNA binding surface [nucleotide binding]; other site
440085011941	anticodon binding site; other site
440085011942	DNA polymerase III subunit delta'; Validated; Region: PRK07471
440085011943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
440085011944	DNA polymerase III subunit delta'; Validated; Region: PRK08485
440085011945	thymidylate kinase; Validated; Region: tmk; PRK00698
440085011946	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
440085011947	TMP-binding site; other site
440085011948	ATP-binding site [chemical binding]; other site
440085011949	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
440085011950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085011951	dimer interface [polypeptide binding]; other site
440085011952	conserved gate region; other site
440085011953	putative PBP binding loops; other site
440085011954	ABC-ATPase subunit interface; other site
440085011955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
440085011956	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
440085011957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085011958	Walker A/P-loop; other site
440085011959	ATP binding site [chemical binding]; other site
440085011960	Q-loop/lid; other site
440085011961	ABC transporter signature motif; other site
440085011962	Walker B; other site
440085011963	D-loop; other site
440085011964	H-loop/switch region; other site
440085011965	TOBE domain; Region: TOBE_2; pfam08402
440085011966	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085011967	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
440085011968	ligand binding site [chemical binding]; other site
440085011969	flexible hinge region; other site
440085011970	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
440085011971	Predicted membrane protein [Function unknown]; Region: COG5373
440085011972	Predicted membrane protein [Function unknown]; Region: COG5373
440085011973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085011974	D-galactonate transporter; Region: 2A0114; TIGR00893
440085011975	putative substrate translocation pore; other site
440085011976	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
440085011977	homodimer interface [polypeptide binding]; other site
440085011978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085011979	catalytic residue [active]
440085011980	Transcriptional regulators [Transcription]; Region: GntR; COG1802
440085011981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085011982	DNA-binding site [nucleotide binding]; DNA binding site
440085011983	FCD domain; Region: FCD; pfam07729
440085011984	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
440085011985	short chain dehydrogenase; Provisional; Region: PRK06701
440085011986	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
440085011987	NAD binding site [chemical binding]; other site
440085011988	metal binding site [ion binding]; metal-binding site
440085011989	active site
440085011990	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
440085011991	FAD binding domain; Region: FAD_binding_4; pfam01565
440085011992	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
440085011993	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
440085011994	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
440085011995	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
440085011996	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
440085011997	tetramerization interface [polypeptide binding]; other site
440085011998	NAD(P) binding site [chemical binding]; other site
440085011999	catalytic residues [active]
440085012000	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
440085012001	Chain length determinant protein; Region: Wzz; pfam02706
440085012002	O-Antigen ligase; Region: Wzy_C; pfam04932
440085012003	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
440085012004	lipoate-protein ligase B; Provisional; Region: PRK14341
440085012005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
440085012006	active site
440085012007	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085012008	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085012009	Domain of unknown function DUF20; Region: UPF0118; pfam01594
440085012010	Response regulator receiver domain; Region: Response_reg; pfam00072
440085012011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012012	active site
440085012013	phosphorylation site [posttranslational modification]
440085012014	intermolecular recognition site; other site
440085012015	dimerization interface [polypeptide binding]; other site
440085012016	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
440085012017	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
440085012018	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
440085012019	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
440085012020	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
440085012021	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
440085012022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012023	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085012024	putative active site [active]
440085012025	heme pocket [chemical binding]; other site
440085012026	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012027	putative active site [active]
440085012028	heme pocket [chemical binding]; other site
440085012029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085012030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085012031	dimer interface [polypeptide binding]; other site
440085012032	phosphorylation site [posttranslational modification]
440085012033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012034	ATP binding site [chemical binding]; other site
440085012035	Mg2+ binding site [ion binding]; other site
440085012036	G-X-G motif; other site
440085012037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012038	active site
440085012039	phosphorylation site [posttranslational modification]
440085012040	intermolecular recognition site; other site
440085012041	dimerization interface [polypeptide binding]; other site
440085012042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012043	active site
440085012044	phosphorylation site [posttranslational modification]
440085012045	intermolecular recognition site; other site
440085012046	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085012047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012048	active site
440085012049	phosphorylation site [posttranslational modification]
440085012050	intermolecular recognition site; other site
440085012051	dimerization interface [polypeptide binding]; other site
440085012052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085012053	DNA binding residues [nucleotide binding]
440085012054	dimerization interface [polypeptide binding]; other site
440085012055	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
440085012056	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
440085012057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
440085012058	L-lactate permease; Region: Lactate_perm; cl00701
440085012059	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
440085012060	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
440085012061	dimanganese center [ion binding]; other site
440085012062	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
440085012063	substrate binding pocket [chemical binding]; other site
440085012064	substrate-Mg2+ binding site; other site
440085012065	aspartate-rich region 2; other site
440085012066	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
440085012067	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
440085012068	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
440085012069	Protein export membrane protein; Region: SecD_SecF; pfam02355
440085012070	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
440085012071	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
440085012072	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
440085012073	Preprotein translocase subunit; Region: YajC; pfam02699
440085012074	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
440085012075	Protein of unknown function (DUF815); Region: DUF815; pfam05673
440085012076	Walker A motif; other site
440085012077	ATP binding site [chemical binding]; other site
440085012078	Walker B motif; other site
440085012079	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
440085012080	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085012081	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
440085012082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085012083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085012084	S-adenosylmethionine binding site [chemical binding]; other site
440085012085	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
440085012086	seryl-tRNA synthetase; Provisional; Region: PRK05431
440085012087	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
440085012088	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
440085012089	dimer interface [polypeptide binding]; other site
440085012090	active site
440085012091	motif 1; other site
440085012092	motif 2; other site
440085012093	motif 3; other site
440085012094	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
440085012095	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
440085012096	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
440085012097	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
440085012098	substrate binding site [chemical binding]; other site
440085012099	oxyanion hole (OAH) forming residues; other site
440085012100	trimer interface [polypeptide binding]; other site
440085012101	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
440085012102	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
440085012103	dimer interface [polypeptide binding]; other site
440085012104	allosteric magnesium binding site [ion binding]; other site
440085012105	active site
440085012106	aspartate-rich active site metal binding site; other site
440085012107	Schiff base residues; other site
440085012108	RDD family; Region: RDD; pfam06271
440085012109	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
440085012110	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
440085012111	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
440085012112	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
440085012113	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
440085012114	maltose O-acetyltransferase; Provisional; Region: PRK10092
440085012115	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
440085012116	active site
440085012117	substrate binding site [chemical binding]; other site
440085012118	trimer interface [polypeptide binding]; other site
440085012119	CoA binding site [chemical binding]; other site
440085012120	Predicted metalloprotease [General function prediction only]; Region: COG2321
440085012121	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
440085012122	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
440085012123	Fe-S cluster binding site [ion binding]; other site
440085012124	active site
440085012125	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
440085012126	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
440085012127	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
440085012128	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
440085012129	putative active site pocket [active]
440085012130	cleavage site
440085012131	Predicted permeases [General function prediction only]; Region: RarD; COG2962
440085012132	cystathionine beta-lyase; Provisional; Region: PRK05967
440085012133	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085012134	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085012135	catalytic residue [active]
440085012136	Uncharacterized conserved protein [Function unknown]; Region: COG5361
440085012137	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
440085012138	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
440085012139	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
440085012140	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
440085012141	PAS fold; Region: PAS_4; pfam08448
440085012142	PAS domain; Region: PAS; smart00091
440085012143	PAS fold; Region: PAS_4; pfam08448
440085012144	PAS domain S-box; Region: sensory_box; TIGR00229
440085012145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012146	putative active site [active]
440085012147	heme pocket [chemical binding]; other site
440085012148	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085012149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012150	putative active site [active]
440085012151	heme pocket [chemical binding]; other site
440085012152	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085012153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012154	putative active site [active]
440085012155	heme pocket [chemical binding]; other site
440085012156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085012157	dimer interface [polypeptide binding]; other site
440085012158	phosphorylation site [posttranslational modification]
440085012159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012160	ATP binding site [chemical binding]; other site
440085012161	Mg2+ binding site [ion binding]; other site
440085012162	G-X-G motif; other site
440085012163	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085012164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012165	active site
440085012166	phosphorylation site [posttranslational modification]
440085012167	intermolecular recognition site; other site
440085012168	dimerization interface [polypeptide binding]; other site
440085012169	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
440085012170	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
440085012171	Probable Catalytic site; other site
440085012172	metal-binding site
440085012173	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
440085012174	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
440085012175	Probable Catalytic site; other site
440085012176	metal-binding site
440085012177	Cupin domain; Region: Cupin_2; cl17218
440085012178	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
440085012179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085012180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085012181	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
440085012182	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
440085012183	putative dimer interface [polypeptide binding]; other site
440085012184	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
440085012185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012186	ATP binding site [chemical binding]; other site
440085012187	Mg2+ binding site [ion binding]; other site
440085012188	G-X-G motif; other site
440085012189	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
440085012190	ATP binding site [chemical binding]; other site
440085012191	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
440085012192	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085012193	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085012194	active site
440085012195	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
440085012196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085012197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085012198	ABC transporter; Region: ABC_tran_2; pfam12848
440085012199	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
440085012200	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085012201	RibD C-terminal domain; Region: RibD_C; cl17279
440085012202	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
440085012203	OsmC-like protein; Region: OsmC; cl00767
440085012204	Domain of unknown function (DUF336); Region: DUF336; cl01249
440085012205	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
440085012206	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
440085012207	peptide binding site [polypeptide binding]; other site
440085012208	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
440085012209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085012210	dimer interface [polypeptide binding]; other site
440085012211	conserved gate region; other site
440085012212	putative PBP binding loops; other site
440085012213	ABC-ATPase subunit interface; other site
440085012214	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
440085012215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085012216	ABC-ATPase subunit interface; other site
440085012217	benzoate transport; Region: 2A0115; TIGR00895
440085012218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
440085012221	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085012222	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085012223	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085012224	dimerization interface [polypeptide binding]; other site
440085012225	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
440085012226	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
440085012227	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
440085012228	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
440085012229	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
440085012230	DsbD alpha interface [polypeptide binding]; other site
440085012231	catalytic residues [active]
440085012232	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
440085012233	MutS domain I; Region: MutS_I; pfam01624
440085012234	MutS domain II; Region: MutS_II; pfam05188
440085012235	MutS domain III; Region: MutS_III; pfam05192
440085012236	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
440085012237	Walker A/P-loop; other site
440085012238	ATP binding site [chemical binding]; other site
440085012239	Q-loop/lid; other site
440085012240	ABC transporter signature motif; other site
440085012241	Walker B; other site
440085012242	D-loop; other site
440085012243	H-loop/switch region; other site
440085012244	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
440085012245	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085012246	ATP binding site [chemical binding]; other site
440085012247	putative Mg++ binding site [ion binding]; other site
440085012248	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085012249	nucleotide binding region [chemical binding]; other site
440085012250	ATP-binding site [chemical binding]; other site
440085012251	Helicase associated domain (HA2); Region: HA2; pfam04408
440085012252	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
440085012253	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
440085012254	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
440085012255	active site
440085012256	dimer interface [polypeptide binding]; other site
440085012257	metal binding site [ion binding]; metal-binding site
440085012258	glutathione binding site [chemical binding]; other site
440085012259	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
440085012260	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085012261	active site
440085012262	DNA binding site [nucleotide binding]
440085012263	Int/Topo IB signature motif; other site
440085012264	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085012265	catalytic core [active]
440085012266	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
440085012267	Predicted ATPase [General function prediction only]; Region: COG4637
440085012268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085012269	Walker A/P-loop; other site
440085012270	ATP binding site [chemical binding]; other site
440085012271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
440085012272	MOSC domain; Region: MOSC; pfam03473
440085012273	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
440085012274	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
440085012275	NAD binding site [chemical binding]; other site
440085012276	homotetramer interface [polypeptide binding]; other site
440085012277	homodimer interface [polypeptide binding]; other site
440085012278	substrate binding site [chemical binding]; other site
440085012279	active site
440085012280	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
440085012281	HSP70 interaction site [polypeptide binding]; other site
440085012282	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
440085012283	substrate binding site [polypeptide binding]; other site
440085012284	dimer interface [polypeptide binding]; other site
440085012285	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
440085012286	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
440085012287	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
440085012288	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
440085012289	Response regulator receiver domain; Region: Response_reg; pfam00072
440085012290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012291	active site
440085012292	phosphorylation site [posttranslational modification]
440085012293	intermolecular recognition site; other site
440085012294	dimerization interface [polypeptide binding]; other site
440085012295	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
440085012296	classical (c) SDRs; Region: SDR_c; cd05233
440085012297	NAD(P) binding site [chemical binding]; other site
440085012298	active site
440085012299	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
440085012300	nudix motif; other site
440085012301	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
440085012302	dihydroorotase; Validated; Region: PRK09060
440085012303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085012304	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
440085012305	active site
440085012306	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
440085012307	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
440085012308	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
440085012309	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
440085012310	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
440085012311	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
440085012312	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
440085012313	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
440085012314	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
440085012315	TPP-binding site; other site
440085012316	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
440085012317	PYR/PP interface [polypeptide binding]; other site
440085012318	dimer interface [polypeptide binding]; other site
440085012319	TPP binding site [chemical binding]; other site
440085012320	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
440085012321	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
440085012322	E-class dimer interface [polypeptide binding]; other site
440085012323	P-class dimer interface [polypeptide binding]; other site
440085012324	active site
440085012325	Cu2+ binding site [ion binding]; other site
440085012326	Zn2+ binding site [ion binding]; other site
440085012327	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
440085012328	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085012329	RNA binding surface [nucleotide binding]; other site
440085012330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085012331	S-adenosylmethionine binding site [chemical binding]; other site
440085012332	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
440085012333	Protein of unknown function (DUF563); Region: DUF563; pfam04577
440085012334	DHHW protein; Region: DHHW; pfam14286
440085012335	Uncharacterized conserved protein [Function unknown]; Region: COG2135
440085012336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
440085012337	Protein of unknown function, DUF482; Region: DUF482; pfam04339
440085012338	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
440085012339	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
440085012340	metal binding site [ion binding]; metal-binding site
440085012341	putative dimer interface [polypeptide binding]; other site
440085012342	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
440085012343	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
440085012344	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
440085012345	DNA binding site [nucleotide binding]
440085012346	active site
440085012347	Cation efflux family; Region: Cation_efflux; pfam01545
440085012348	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
440085012349	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
440085012350	HIT family signature motif; other site
440085012351	catalytic residue [active]
440085012352	PilZ domain; Region: PilZ; pfam07238
440085012353	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
440085012354	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
440085012355	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
440085012356	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085012357	active site
440085012358	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
440085012359	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
440085012360	dimer interface [polypeptide binding]; other site
440085012361	active site
440085012362	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
440085012363	dimer interface [polypeptide binding]; other site
440085012364	active site
440085012365	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
440085012366	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
440085012367	putative active site [active]
440085012368	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
440085012369	putative catalytic site [active]
440085012370	putative metal binding site [ion binding]; other site
440085012371	putative phosphate binding site [ion binding]; other site
440085012372	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
440085012373	active site
440085012374	homotetramer interface [polypeptide binding]; other site
440085012375	homodimer interface [polypeptide binding]; other site
440085012376	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
440085012377	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
440085012378	putative active site [active]
440085012379	catalytic site [active]
440085012380	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
440085012381	putative active site [active]
440085012382	catalytic site [active]
440085012383	Uncharacterized conserved protein [Function unknown]; Region: COG0398
440085012384	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
440085012385	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
440085012386	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
440085012387	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
440085012388	Subunit I/III interface [polypeptide binding]; other site
440085012389	Subunit III/IV interface [polypeptide binding]; other site
440085012390	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
440085012391	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
440085012392	D-pathway; other site
440085012393	Putative ubiquinol binding site [chemical binding]; other site
440085012394	Low-spin heme (heme b) binding site [chemical binding]; other site
440085012395	Putative water exit pathway; other site
440085012396	Binuclear center (heme o3/CuB) [ion binding]; other site
440085012397	K-pathway; other site
440085012398	Putative proton exit pathway; other site
440085012399	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
440085012400	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
440085012401	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
440085012402	metabolite-proton symporter; Region: 2A0106; TIGR00883
440085012403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012404	putative substrate translocation pore; other site
440085012405	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
440085012406	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085012407	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085012408	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085012409	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085012410	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085012411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085012412	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085012413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012414	active site
440085012415	phosphorylation site [posttranslational modification]
440085012416	intermolecular recognition site; other site
440085012417	dimerization interface [polypeptide binding]; other site
440085012418	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085012419	DNA binding residues [nucleotide binding]
440085012420	dimerization interface [polypeptide binding]; other site
440085012421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
440085012422	Histidine kinase; Region: HisKA_3; pfam07730
440085012423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012424	ATP binding site [chemical binding]; other site
440085012425	Mg2+ binding site [ion binding]; other site
440085012426	G-X-G motif; other site
440085012427	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085012428	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085012429	DNA binding residues [nucleotide binding]
440085012430	dimerization interface [polypeptide binding]; other site
440085012431	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085012432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012433	active site
440085012434	phosphorylation site [posttranslational modification]
440085012435	intermolecular recognition site; other site
440085012436	dimerization interface [polypeptide binding]; other site
440085012437	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085012438	DNA binding residues [nucleotide binding]
440085012439	dimerization interface [polypeptide binding]; other site
440085012440	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085012441	active site
440085012442	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
440085012443	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085012444	Int/Topo IB signature motif; other site
440085012445	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085012446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085012447	non-specific DNA binding site [nucleotide binding]; other site
440085012448	salt bridge; other site
440085012449	sequence-specific DNA binding site [nucleotide binding]; other site
440085012450	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
440085012451	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
440085012452	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
440085012453	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
440085012454	PLD-like domain; Region: PLDc_2; pfam13091
440085012455	homodimer interface [polypeptide binding]; other site
440085012456	putative active site [active]
440085012457	catalytic site [active]
440085012458	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
440085012459	putative homodimer interface [polypeptide binding]; other site
440085012460	putative homotetramer interface [polypeptide binding]; other site
440085012461	putative metal binding site [ion binding]; other site
440085012462	putative homodimer-homodimer interface [polypeptide binding]; other site
440085012463	putative allosteric switch controlling residues; other site
440085012464	H+ Antiporter protein; Region: 2A0121; TIGR00900
440085012465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012466	putative substrate translocation pore; other site
440085012467	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
440085012468	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085012469	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085012470	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
440085012471	active site residue [active]
440085012472	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
440085012473	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
440085012474	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
440085012475	Chromate transporter; Region: Chromate_transp; pfam02417
440085012476	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
440085012477	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
440085012478	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
440085012479	Part of AAA domain; Region: AAA_19; pfam13245
440085012480	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
440085012481	AAA domain; Region: AAA_12; pfam13087
440085012482	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
440085012483	putative active site [active]
440085012484	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
440085012485	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
440085012486	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
440085012487	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
440085012488	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
440085012489	putative ligand binding site [chemical binding]; other site
440085012490	putative NAD binding site [chemical binding]; other site
440085012491	catalytic site [active]
440085012492	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085012493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085012494	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
440085012495	putative dimerization interface [polypeptide binding]; other site
440085012496	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
440085012497	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
440085012498	putative ligand binding site [chemical binding]; other site
440085012499	NAD binding site [chemical binding]; other site
440085012500	catalytic site [active]
440085012501	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
440085012502	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
440085012503	substrate binding site [chemical binding]; other site
440085012504	ligand binding site [chemical binding]; other site
440085012505	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085012506	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085012507	active site
440085012508	catalytic residues [active]
440085012509	DNA binding site [nucleotide binding]
440085012510	Int/Topo IB signature motif; other site
440085012511	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
440085012512	putative active site [active]
440085012513	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
440085012514	ligand-binding site [chemical binding]; other site
440085012515	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
440085012516	active site
440085012517	oxyanion hole [active]
440085012518	catalytic triad [active]
440085012519	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
440085012520	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
440085012521	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085012522	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085012523	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085012524	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
440085012525	Surface antigen; Region: Bac_surface_Ag; pfam01103
440085012526	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012527	PAS fold; Region: PAS; pfam00989
440085012528	putative active site [active]
440085012529	heme pocket [chemical binding]; other site
440085012530	Sensors of blue-light using FAD; Region: BLUF; pfam04940
440085012531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085012532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085012533	dimer interface [polypeptide binding]; other site
440085012534	phosphorylation site [posttranslational modification]
440085012535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012536	ATP binding site [chemical binding]; other site
440085012537	Mg2+ binding site [ion binding]; other site
440085012538	G-X-G motif; other site
440085012539	Response regulator receiver domain; Region: Response_reg; pfam00072
440085012540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012541	active site
440085012542	phosphorylation site [posttranslational modification]
440085012543	intermolecular recognition site; other site
440085012544	dimerization interface [polypeptide binding]; other site
440085012545	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
440085012546	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085012547	PAS domain S-box; Region: sensory_box; TIGR00229
440085012548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012549	putative active site [active]
440085012550	heme pocket [chemical binding]; other site
440085012551	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085012552	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085012553	metal binding site [ion binding]; metal-binding site
440085012554	active site
440085012555	I-site; other site
440085012556	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085012557	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
440085012558	active site
440085012559	catalytic residues [active]
440085012560	DNA binding site [nucleotide binding]
440085012561	Int/Topo IB signature motif; other site
440085012562	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085012563	dimerization interface [polypeptide binding]; other site
440085012564	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085012565	dimer interface [polypeptide binding]; other site
440085012566	putative CheW interface [polypeptide binding]; other site
440085012567	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
440085012568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012570	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085012571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085012572	non-specific DNA binding site [nucleotide binding]; other site
440085012573	salt bridge; other site
440085012574	sequence-specific DNA binding site [nucleotide binding]; other site
440085012575	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
440085012576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012577	active site
440085012578	phosphorylation site [posttranslational modification]
440085012579	intermolecular recognition site; other site
440085012580	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085012581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012582	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
440085012583	putative active site [active]
440085012584	heme pocket [chemical binding]; other site
440085012585	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012586	putative active site [active]
440085012587	heme pocket [chemical binding]; other site
440085012588	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085012589	HWE histidine kinase; Region: HWE_HK; smart00911
440085012590	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
440085012591	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085012592	N-terminal plug; other site
440085012593	ligand-binding site [chemical binding]; other site
440085012594	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
440085012595	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
440085012596	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
440085012597	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
440085012598	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
440085012599	DXD motif; other site
440085012600	Response regulator receiver domain; Region: Response_reg; pfam00072
440085012601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012602	active site
440085012603	phosphorylation site [posttranslational modification]
440085012604	intermolecular recognition site; other site
440085012605	dimerization interface [polypeptide binding]; other site
440085012606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
440085012607	Transposase; Region: DDE_Tnp_ISL3; pfam01610
440085012608	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
440085012609	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
440085012610	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085012611	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085012612	GAF domain; Region: GAF; pfam01590
440085012613	PAS domain S-box; Region: sensory_box; TIGR00229
440085012614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012615	putative active site [active]
440085012616	heme pocket [chemical binding]; other site
440085012617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085012618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085012619	metal binding site [ion binding]; metal-binding site
440085012620	active site
440085012621	I-site; other site
440085012622	PAS fold; Region: PAS_4; pfam08448
440085012623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012624	PAS fold; Region: PAS_3; pfam08447
440085012625	putative active site [active]
440085012626	heme pocket [chemical binding]; other site
440085012627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012628	PAS fold; Region: PAS_3; pfam08447
440085012629	putative active site [active]
440085012630	heme pocket [chemical binding]; other site
440085012631	PAS fold; Region: PAS_3; pfam08447
440085012632	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
440085012633	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085012634	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085012635	metal binding site [ion binding]; metal-binding site
440085012636	active site
440085012637	I-site; other site
440085012638	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085012639	Transposase; Region: HTH_Tnp_1; cl17663
440085012640	HTH-like domain; Region: HTH_21; pfam13276
440085012641	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
440085012642	Integrase core domain; Region: rve; pfam00665
440085012643	Integrase core domain; Region: rve_3; pfam13683
440085012644	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
440085012645	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
440085012646	putative heme binding pocket [chemical binding]; other site
440085012647	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085012648	Ligand Binding Site [chemical binding]; other site
440085012649	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085012650	dimer interface [polypeptide binding]; other site
440085012651	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085012652	putative CheW interface [polypeptide binding]; other site
440085012653	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
440085012654	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
440085012655	conserved cys residue [active]
440085012656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085012657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085012658	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
440085012659	hexamer interface [polypeptide binding]; other site
440085012660	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
440085012661	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
440085012662	putative heme binding site [chemical binding]; other site
440085012663	putative substrate binding site [chemical binding]; other site
440085012664	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
440085012665	Protein of unknown function (DUF587); Region: DUF587; pfam04532
440085012666	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085012667	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085012668	non-specific DNA binding site [nucleotide binding]; other site
440085012669	salt bridge; other site
440085012670	sequence-specific DNA binding site [nucleotide binding]; other site
440085012671	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
440085012672	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
440085012673	potential catalytic triad [active]
440085012674	conserved cys residue [active]
440085012675	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
440085012676	Amidase; Region: Amidase; pfam01425
440085012677	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
440085012678	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085012679	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085012680	ligand binding site [chemical binding]; other site
440085012681	flexible hinge region; other site
440085012682	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
440085012683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085012684	Cupin; Region: Cupin_6; pfam12852
440085012685	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085012686	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
440085012687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
440085012688	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
440085012689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
440085012690	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
440085012691	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
440085012692	conserved cys residue [active]
440085012693	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
440085012694	NMT1-like family; Region: NMT1_2; pfam13379
440085012695	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
440085012696	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085012697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085012698	dimer interface [polypeptide binding]; other site
440085012699	conserved gate region; other site
440085012700	putative PBP binding loops; other site
440085012701	ABC-ATPase subunit interface; other site
440085012702	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085012703	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085012704	Walker A/P-loop; other site
440085012705	ATP binding site [chemical binding]; other site
440085012706	Q-loop/lid; other site
440085012707	ABC transporter signature motif; other site
440085012708	Walker B; other site
440085012709	D-loop; other site
440085012710	H-loop/switch region; other site
440085012711	tellurite resistance protein terB; Region: terB; cd07176
440085012712	putative metal binding site [ion binding]; other site
440085012713	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
440085012714	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
440085012715	G1 box; other site
440085012716	putative GEF interaction site [polypeptide binding]; other site
440085012717	GTP/Mg2+ binding site [chemical binding]; other site
440085012718	Switch I region; other site
440085012719	G2 box; other site
440085012720	G3 box; other site
440085012721	Switch II region; other site
440085012722	G4 box; other site
440085012723	G5 box; other site
440085012724	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
440085012725	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
440085012726	classical (c) SDRs; Region: SDR_c; cd05233
440085012727	NAD(P) binding site [chemical binding]; other site
440085012728	active site
440085012729	elongation factor Tu; Reviewed; Region: PRK00049
440085012730	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
440085012731	G1 box; other site
440085012732	GEF interaction site [polypeptide binding]; other site
440085012733	GTP/Mg2+ binding site [chemical binding]; other site
440085012734	Switch I region; other site
440085012735	G2 box; other site
440085012736	G3 box; other site
440085012737	Switch II region; other site
440085012738	G4 box; other site
440085012739	G5 box; other site
440085012740	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
440085012741	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
440085012742	Antibiotic Binding Site [chemical binding]; other site
440085012743	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085012744	RNA binding surface [nucleotide binding]; other site
440085012745	DEAD/DEAH box helicase; Region: DEAD; pfam00270
440085012746	ATP binding site [chemical binding]; other site
440085012747	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
440085012748	putative Mg++ binding site [ion binding]; other site
440085012749	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085012750	nucleotide binding region [chemical binding]; other site
440085012751	ATP-binding site [chemical binding]; other site
440085012752	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
440085012753	Heme NO binding; Region: HNOB; pfam07700
440085012754	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085012755	metal binding site [ion binding]; metal-binding site
440085012756	active site
440085012757	I-site; other site
440085012758	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
440085012759	Glucokinase; Region: Glucokinase; cl17310
440085012760	glucokinase, proteobacterial type; Region: glk; TIGR00749
440085012761	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
440085012762	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
440085012763	Domain of unknown function (DUF427); Region: DUF427; pfam04248
440085012764	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
440085012765	Beta-lactamase; Region: Beta-lactamase; pfam00144
440085012766	BCCT family transporter; Region: BCCT; pfam02028
440085012767	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
440085012768	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
440085012769	putative dimer interface [polypeptide binding]; other site
440085012770	[2Fe-2S] cluster binding site [ion binding]; other site
440085012771	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
440085012772	putative dimer interface [polypeptide binding]; other site
440085012773	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
440085012774	SLBB domain; Region: SLBB; pfam10531
440085012775	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
440085012776	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
440085012777	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085012778	catalytic loop [active]
440085012779	iron binding site [ion binding]; other site
440085012780	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
440085012781	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
440085012782	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
440085012783	[4Fe-4S] binding site [ion binding]; other site
440085012784	molybdopterin cofactor binding site; other site
440085012785	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
440085012786	molybdopterin cofactor binding site; other site
440085012787	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
440085012788	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085012789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085012790	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
440085012791	dimerization interface [polypeptide binding]; other site
440085012792	GTPase CgtA; Reviewed; Region: obgE; PRK12299
440085012793	GTP1/OBG; Region: GTP1_OBG; pfam01018
440085012794	Obg GTPase; Region: Obg; cd01898
440085012795	G1 box; other site
440085012796	GTP/Mg2+ binding site [chemical binding]; other site
440085012797	Switch I region; other site
440085012798	G2 box; other site
440085012799	G3 box; other site
440085012800	Switch II region; other site
440085012801	G4 box; other site
440085012802	G5 box; other site
440085012803	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
440085012804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
440085012805	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
440085012806	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
440085012807	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
440085012808	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
440085012809	Putative hemolysin [General function prediction only]; Region: COG3176
440085012810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085012811	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085012812	putative substrate translocation pore; other site
440085012813	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
440085012814	nucleophile elbow; other site
440085012815	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
440085012816	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
440085012817	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
440085012818	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
440085012819	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085012820	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085012821	active site
440085012822	metal binding site [ion binding]; metal-binding site
440085012823	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
440085012824	Na binding site [ion binding]; other site
440085012825	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
440085012826	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085012827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085012828	putative active site [active]
440085012829	heme pocket [chemical binding]; other site
440085012830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085012831	dimer interface [polypeptide binding]; other site
440085012832	phosphorylation site [posttranslational modification]
440085012833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012834	ATP binding site [chemical binding]; other site
440085012835	Mg2+ binding site [ion binding]; other site
440085012836	G-X-G motif; other site
440085012837	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085012838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012839	active site
440085012840	phosphorylation site [posttranslational modification]
440085012841	intermolecular recognition site; other site
440085012842	dimerization interface [polypeptide binding]; other site
440085012843	tellurite resistance protein terB; Region: terB; cd07176
440085012844	putative metal binding site [ion binding]; other site
440085012845	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
440085012846	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
440085012847	Substrate binding site; other site
440085012848	metal-binding site
440085012849	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
440085012850	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
440085012851	Phosphotransferase enzyme family; Region: APH; pfam01636
440085012852	PAS fold; Region: PAS_7; pfam12860
440085012853	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
440085012854	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085012855	dimer interface [polypeptide binding]; other site
440085012856	phosphorylation site [posttranslational modification]
440085012857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012858	ATP binding site [chemical binding]; other site
440085012859	Mg2+ binding site [ion binding]; other site
440085012860	G-X-G motif; other site
440085012861	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
440085012862	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
440085012863	homotetramer interface [polypeptide binding]; other site
440085012864	ligand binding site [chemical binding]; other site
440085012865	catalytic site [active]
440085012866	NAD binding site [chemical binding]; other site
440085012867	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
440085012868	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085012869	acyl-activating enzyme (AAE) consensus motif; other site
440085012870	AMP binding site [chemical binding]; other site
440085012871	active site
440085012872	CoA binding site [chemical binding]; other site
440085012873	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
440085012874	putative FMN binding site [chemical binding]; other site
440085012875	enoyl-CoA hydratase; Validated; Region: PRK08139
440085012876	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
440085012877	substrate binding site [chemical binding]; other site
440085012878	oxyanion hole (OAH) forming residues; other site
440085012879	trimer interface [polypeptide binding]; other site
440085012880	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
440085012881	putative catalytic site [active]
440085012882	putative metal binding site [ion binding]; other site
440085012883	putative phosphate binding site [ion binding]; other site
440085012884	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
440085012885	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
440085012886	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
440085012887	putative active site [active]
440085012888	catalytic site [active]
440085012889	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
440085012890	putative active site [active]
440085012891	catalytic site [active]
440085012892	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
440085012893	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
440085012894	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
440085012895	Family description; Region: UvrD_C_2; pfam13538
440085012896	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
440085012897	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
440085012898	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
440085012899	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
440085012900	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
440085012901	catalytic residues [active]
440085012902	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
440085012903	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085012904	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
440085012905	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
440085012906	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
440085012907	substrate binding site [chemical binding]; other site
440085012908	active site
440085012909	catalytic residues [active]
440085012910	heterodimer interface [polypeptide binding]; other site
440085012911	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
440085012912	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
440085012913	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
440085012914	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
440085012915	putative NADH binding site [chemical binding]; other site
440085012916	putative active site [active]
440085012917	nudix motif; other site
440085012918	putative metal binding site [ion binding]; other site
440085012919	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
440085012920	nucleotide binding site/active site [active]
440085012921	HIT family signature motif; other site
440085012922	catalytic residue [active]
440085012923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
440085012924	active site
440085012925	phosphorylation site [posttranslational modification]
440085012926	intermolecular recognition site; other site
440085012927	dimerization interface [polypeptide binding]; other site
440085012928	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
440085012929	Zn2+ binding site [ion binding]; other site
440085012930	Mg2+ binding site [ion binding]; other site
440085012931	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
440085012932	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
440085012933	ATP binding site [chemical binding]; other site
440085012934	putative Mg++ binding site [ion binding]; other site
440085012935	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
440085012936	nucleotide binding region [chemical binding]; other site
440085012937	ATP-binding site [chemical binding]; other site
440085012938	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
440085012939	RNA binding site [nucleotide binding]; other site
440085012940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085012941	dimerization interface [polypeptide binding]; other site
440085012942	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
440085012943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085012944	ATP binding site [chemical binding]; other site
440085012945	G-X-G motif; other site
440085012946	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085012947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085012948	active site
440085012949	phosphorylation site [posttranslational modification]
440085012950	intermolecular recognition site; other site
440085012951	dimerization interface [polypeptide binding]; other site
440085012952	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085012953	DNA binding residues [nucleotide binding]
440085012954	dimerization interface [polypeptide binding]; other site
440085012955	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
440085012956	amino acid transporter; Region: 2A0306; TIGR00909
440085012957	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
440085012958	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
440085012959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
440085012960	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085012961	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
440085012962	Walker A/P-loop; other site
440085012963	ATP binding site [chemical binding]; other site
440085012964	Q-loop/lid; other site
440085012965	ABC transporter signature motif; other site
440085012966	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
440085012967	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
440085012968	putative active site [active]
440085012969	putative dimer interface [polypeptide binding]; other site
440085012970	RNA polymerase sigma factor; Provisional; Region: PRK12547
440085012971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085012972	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085012973	DNA binding residues [nucleotide binding]
440085012974	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085012975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
440085012976	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
440085012977	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
440085012978	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
440085012979	putative binding surface; other site
440085012980	active site
440085012981	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
440085012982	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
440085012983	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085012984	non-specific DNA binding site [nucleotide binding]; other site
440085012985	salt bridge; other site
440085012986	sequence-specific DNA binding site [nucleotide binding]; other site
440085012987	Cupin domain; Region: Cupin_2; pfam07883
440085012988	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
440085012989	dimer interface [polypeptide binding]; other site
440085012990	substrate binding site [chemical binding]; other site
440085012991	ATP binding site [chemical binding]; other site
440085012992	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
440085012993	active site
440085012994	thiamine phosphate binding site [chemical binding]; other site
440085012995	pyrophosphate binding site [ion binding]; other site
440085012996	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
440085012997	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085012998	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
440085012999	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
440085013000	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
440085013001	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
440085013002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085013003	S-adenosylmethionine binding site [chemical binding]; other site
440085013004	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
440085013005	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
440085013006	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
440085013007	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
440085013008	active site
440085013009	Low molecular weight phosphatase family; Region: LMWPc; cd00115
440085013010	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
440085013011	active site
440085013012	Fructosamine kinase; Region: Fructosamin_kin; cl17579
440085013013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
440085013014	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
440085013015	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
440085013016	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
440085013017	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
440085013018	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
440085013019	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
440085013020	putative C-terminal domain interface [polypeptide binding]; other site
440085013021	putative GSH binding site (G-site) [chemical binding]; other site
440085013022	putative dimer interface [polypeptide binding]; other site
440085013023	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
440085013024	putative N-terminal domain interface [polypeptide binding]; other site
440085013025	putative dimer interface [polypeptide binding]; other site
440085013026	putative substrate binding pocket (H-site) [chemical binding]; other site
440085013027	transcriptional regulator; Provisional; Region: PRK10632
440085013028	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085013029	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
440085013030	putative effector binding pocket; other site
440085013031	putative dimerization interface [polypeptide binding]; other site
440085013032	sulfite reductase; Provisional; Region: PRK06214
440085013033	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
440085013034	FAD binding pocket [chemical binding]; other site
440085013035	FAD binding motif [chemical binding]; other site
440085013036	catalytic residues [active]
440085013037	NAD binding pocket [chemical binding]; other site
440085013038	phosphate binding motif [ion binding]; other site
440085013039	beta-alpha-beta structure motif; other site
440085013040	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
440085013041	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
440085013042	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
440085013043	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
440085013044	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
440085013045	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
440085013046	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
440085013047	Walker A/P-loop; other site
440085013048	ATP binding site [chemical binding]; other site
440085013049	Q-loop/lid; other site
440085013050	ABC transporter signature motif; other site
440085013051	Walker B; other site
440085013052	D-loop; other site
440085013053	H-loop/switch region; other site
440085013054	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
440085013055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085013056	dimer interface [polypeptide binding]; other site
440085013057	conserved gate region; other site
440085013058	putative PBP binding loops; other site
440085013059	ABC-ATPase subunit interface; other site
440085013060	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085013061	NMT1-like family; Region: NMT1_2; pfam13379
440085013062	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
440085013063	NMT1-like family; Region: NMT1_2; pfam13379
440085013064	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
440085013065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
440085013066	active site
440085013067	phosphorylation site [posttranslational modification]
440085013068	intermolecular recognition site; other site
440085013069	ANTAR domain; Region: ANTAR; pfam03861
440085013070	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
440085013071	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
440085013072	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
440085013073	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
440085013074	TPP-binding site [chemical binding]; other site
440085013075	dimer interface [polypeptide binding]; other site
440085013076	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
440085013077	PYR/PP interface [polypeptide binding]; other site
440085013078	dimer interface [polypeptide binding]; other site
440085013079	TPP binding site [chemical binding]; other site
440085013080	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
440085013081	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
440085013082	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
440085013083	putative active site [active]
440085013084	catalytic residue [active]
440085013085	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
440085013086	active site
440085013087	dimer interface [polypeptide binding]; other site
440085013088	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
440085013089	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
440085013090	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
440085013091	PAS domain; Region: PAS_9; pfam13426
440085013092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085013093	putative active site [active]
440085013094	heme pocket [chemical binding]; other site
440085013095	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
440085013096	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085013097	dimer interface [polypeptide binding]; other site
440085013098	putative CheW interface [polypeptide binding]; other site
440085013099	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
440085013100	short chain dehydrogenase; Provisional; Region: PRK07109
440085013101	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
440085013102	putative NAD(P) binding site [chemical binding]; other site
440085013103	active site
440085013104	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
440085013105	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085013106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
440085013107	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085013108	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
440085013109	active site residue [active]
440085013110	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
440085013111	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085013112	Autoinducer synthetase; Region: Autoind_synth; cl17404
440085013113	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
440085013114	Autoinducer binding domain; Region: Autoind_bind; pfam03472
440085013115	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085013116	DNA binding residues [nucleotide binding]
440085013117	dimerization interface [polypeptide binding]; other site
440085013118	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085013119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085013120	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
440085013121	putative substrate binding pocket [chemical binding]; other site
440085013122	putative dimerization interface [polypeptide binding]; other site
440085013123	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085013124	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085013125	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
440085013126	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
440085013127	Trp docking motif [polypeptide binding]; other site
440085013128	active site
440085013129	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085013130	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085013131	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085013132	Histidine kinase; Region: HisKA_2; pfam07568
440085013133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085013134	ATP binding site [chemical binding]; other site
440085013135	Mg2+ binding site [ion binding]; other site
440085013136	G-X-G motif; other site
440085013137	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
440085013138	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085013139	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
440085013140	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085013141	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
440085013142	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
440085013143	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085013144	catalytic loop [active]
440085013145	iron binding site [ion binding]; other site
440085013146	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
440085013147	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
440085013148	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
440085013149	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
440085013150	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
440085013151	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
440085013152	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
440085013153	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
440085013154	Protein of unknown function, DUF606; Region: DUF606; pfam04657
440085013155	Transcriptional regulator [Transcription]; Region: LysR; COG0583
440085013156	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
440085013157	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
440085013158	dimerization interface [polypeptide binding]; other site
440085013159	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
440085013160	Enoylreductase; Region: PKS_ER; smart00829
440085013161	NAD(P) binding site [chemical binding]; other site
440085013162	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085013163	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085013164	PAS domain S-box; Region: sensory_box; TIGR00229
440085013165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085013166	putative active site [active]
440085013167	heme pocket [chemical binding]; other site
440085013168	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085013169	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
440085013170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085013171	PAS fold; Region: PAS_3; pfam08447
440085013172	putative active site [active]
440085013173	heme pocket [chemical binding]; other site
440085013174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085013175	HWE histidine kinase; Region: HWE_HK; smart00911
440085013176	response regulator; Provisional; Region: PRK13435
440085013177	Bacterial SH3 domain; Region: SH3_3; pfam08239
440085013178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085013179	NAD(P) binding site [chemical binding]; other site
440085013180	active site
440085013181	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
440085013182	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
440085013183	dimer interface [polypeptide binding]; other site
440085013184	active site
440085013185	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
440085013186	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
440085013187	active site
440085013188	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
440085013189	active site 2 [active]
440085013190	active site 1 [active]
440085013191	acyl carrier protein; Provisional; Region: PRK06508
440085013192	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085013193	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085013194	active site
440085013195	metal binding site [ion binding]; metal-binding site
440085013196	I-site; other site
440085013197	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085013198	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
440085013199	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
440085013200	Cupin domain; Region: Cupin_2; cl17218
440085013201	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
440085013202	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
440085013203	putative dimer interface [polypeptide binding]; other site
440085013204	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
440085013205	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085013206	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
440085013207	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
440085013208	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
440085013209	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
440085013210	active site
440085013211	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
440085013212	Domain of unknown function DUF20; Region: UPF0118; pfam01594
440085013213	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
440085013214	putative active site [active]
440085013215	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
440085013216	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
440085013217	active site
440085013218	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
440085013219	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
440085013220	Domain of unknown function DUF59; Region: DUF59; pfam01883
440085013221	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
440085013222	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085013223	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
440085013224	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
440085013225	GTP binding site; other site
440085013226	DNA gyrase subunit A; Validated; Region: PRK05560
440085013227	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
440085013228	CAP-like domain; other site
440085013229	active site
440085013230	primary dimer interface [polypeptide binding]; other site
440085013231	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
440085013232	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
440085013233	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
440085013234	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
440085013235	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
440085013236	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
440085013237	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
440085013238	active site
440085013239	(T/H)XGH motif; other site
440085013240	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
440085013241	active site
440085013242	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
440085013243	active site
440085013244	Response regulator receiver domain; Region: Response_reg; pfam00072
440085013245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085013246	active site
440085013247	phosphorylation site [posttranslational modification]
440085013248	intermolecular recognition site; other site
440085013249	dimerization interface [polypeptide binding]; other site
440085013250	Uncharacterized conserved protein [Function unknown]; Region: COG4544
440085013251	DNA Polymerase Y-family; Region: PolY_like; cd03468
440085013252	active site
440085013253	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
440085013254	DNA binding site [nucleotide binding]
440085013255	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
440085013256	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
440085013257	putative active site [active]
440085013258	putative PHP Thumb interface [polypeptide binding]; other site
440085013259	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
440085013260	generic binding surface I; other site
440085013261	generic binding surface II; other site
440085013262	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
440085013263	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
440085013264	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
440085013265	active site
440085013266	nucleophile elbow; other site
440085013267	Patatin phospholipase; Region: DUF3734; pfam12536
440085013268	Ion channel; Region: Ion_trans_2; pfam07885
440085013269	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
440085013270	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
440085013271	putative dimer interface [polypeptide binding]; other site
440085013272	[2Fe-2S] cluster binding site [ion binding]; other site
440085013273	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
440085013274	SLBB domain; Region: SLBB; pfam10531
440085013275	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
440085013276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085013277	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
440085013278	catalytic loop [active]
440085013279	iron binding site [ion binding]; other site
440085013280	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
440085013281	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
440085013282	[4Fe-4S] binding site [ion binding]; other site
440085013283	molybdopterin cofactor binding site; other site
440085013284	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
440085013285	molybdopterin cofactor binding site; other site
440085013286	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
440085013287	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
440085013288	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
440085013289	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
440085013290	putative active site [active]
440085013291	putative metal binding site [ion binding]; other site
440085013292	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
440085013293	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085013294	Right handed beta helix region; Region: Beta_helix; pfam13229
440085013295	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
440085013296	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
440085013297	classical (c) SDRs; Region: SDR_c; cd05233
440085013298	NAD(P) binding site [chemical binding]; other site
440085013299	active site
440085013300	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
440085013301	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085013302	AMP binding site [chemical binding]; other site
440085013303	active site
440085013304	acyl-activating enzyme (AAE) consensus motif; other site
440085013305	CoA binding site [chemical binding]; other site
440085013306	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
440085013307	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
440085013308	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
440085013309	dimer interface [polypeptide binding]; other site
440085013310	active site
440085013311	motif 2; other site
440085013312	motif 3; other site
440085013313	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
440085013314	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
440085013315	active site
440085013316	acyl carrier protein; Provisional; Region: PRK07081
440085013317	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
440085013318	thiamine pyrophosphate protein; Validated; Region: PRK08199
440085013319	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085013320	PYR/PP interface [polypeptide binding]; other site
440085013321	dimer interface [polypeptide binding]; other site
440085013322	TPP binding site [chemical binding]; other site
440085013323	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085013324	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
440085013325	TPP-binding site [chemical binding]; other site
440085013326	aminotransferase; Provisional; Region: PRK13356
440085013327	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
440085013328	homodimer interface [polypeptide binding]; other site
440085013329	substrate-cofactor binding pocket; other site
440085013330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085013331	catalytic residue [active]
440085013332	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
440085013333	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
440085013334	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
440085013335	homodimer interface [polypeptide binding]; other site
440085013336	substrate-cofactor binding pocket; other site
440085013337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085013338	catalytic residue [active]
440085013339	homoserine O-succinyltransferase; Provisional; Region: PRK05368
440085013340	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
440085013341	conserved cys residue [active]
440085013342	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
440085013343	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
440085013344	acyl-activating enzyme (AAE) consensus motif; other site
440085013345	putative AMP binding site [chemical binding]; other site
440085013346	putative active site [active]
440085013347	putative CoA binding site [chemical binding]; other site
440085013348	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
440085013349	Pectate lyase; Region: Pec_lyase_C; cl01593
440085013350	Right handed beta helix region; Region: Beta_helix; pfam13229
440085013351	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
440085013352	Hint domain; Region: Hint_2; pfam13403
440085013353	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
440085013354	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
440085013355	active site
440085013356	hypothetical protein; Provisional; Region: PRK01254
440085013357	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
440085013358	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
440085013359	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
440085013360	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
440085013361	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
440085013362	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
440085013363	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
440085013364	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
440085013365	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
440085013366	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
440085013367	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
440085013368	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
440085013369	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
440085013370	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
440085013371	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
440085013372	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
440085013373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085013374	NAD(P) binding site [chemical binding]; other site
440085013375	active site
440085013376	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
440085013377	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
440085013378	NADP binding site [chemical binding]; other site
440085013379	active site
440085013380	putative substrate binding site [chemical binding]; other site
440085013381	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
440085013382	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
440085013383	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
440085013384	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
440085013385	Condensation domain; Region: Condensation; pfam00668
440085013386	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
440085013387	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
440085013388	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
440085013389	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
440085013390	Condensation domain; Region: Condensation; pfam00668
440085013391	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
440085013392	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
440085013393	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
440085013394	acyl-activating enzyme (AAE) consensus motif; other site
440085013395	AMP binding site [chemical binding]; other site
440085013396	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
440085013397	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085013398	catalytic core [active]
440085013399	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085013400	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085013401	active site
440085013402	catalytic tetrad [active]
440085013403	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085013404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085013405	Walker A motif; other site
440085013406	ATP binding site [chemical binding]; other site
440085013407	Walker B motif; other site
440085013408	arginine finger; other site
440085013409	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085013410	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
440085013411	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
440085013412	TrkA-N domain; Region: TrkA_N; pfam02254
440085013413	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
440085013414	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
440085013415	NAD binding site [chemical binding]; other site
440085013416	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085013417	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
440085013418	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
440085013419	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
440085013420	Mg++ binding site [ion binding]; other site
440085013421	putative catalytic motif [active]
440085013422	putative substrate binding site [chemical binding]; other site
440085013423	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
440085013424	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
440085013425	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085013426	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
440085013427	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
440085013428	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085013429	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
440085013430	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
440085013431	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
440085013432	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
440085013433	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
440085013434	MraW methylase family; Region: Methyltransf_5; cl17771
440085013435	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
440085013436	Ligase N family; Region: LIGANc; smart00532
440085013437	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
440085013438	nucleotide binding pocket [chemical binding]; other site
440085013439	K-X-D-G motif; other site
440085013440	catalytic site [active]
440085013441	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
440085013442	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
440085013443	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
440085013444	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
440085013445	Dimer interface [polypeptide binding]; other site
440085013446	BRCT sequence motif; other site
440085013447	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
440085013448	putative active site [active]
440085013449	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
440085013450	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
440085013451	substrate binding site [chemical binding]; other site
440085013452	ATP binding site [chemical binding]; other site
440085013453	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
440085013454	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
440085013455	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
440085013456	CoA-transferase family III; Region: CoA_transf_3; pfam02515
440085013457	enoyl-CoA hydratase; Provisional; Region: PRK06144
440085013458	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
440085013459	substrate binding site [chemical binding]; other site
440085013460	oxyanion hole (OAH) forming residues; other site
440085013461	trimer interface [polypeptide binding]; other site
440085013462	Transcriptional regulators [Transcription]; Region: FadR; COG2186
440085013463	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085013464	DNA-binding site [nucleotide binding]; DNA binding site
440085013465	FCD domain; Region: FCD; pfam07729
440085013466	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085013467	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
440085013468	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085013469	catalytic residue [active]
440085013470	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
440085013471	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
440085013472	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
440085013473	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
440085013474	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
440085013475	DNA polymerase III subunit chi; Validated; Region: PRK05728
440085013476	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
440085013477	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
440085013478	Predicted membrane protein [Function unknown]; Region: COG3766
440085013479	CTP synthetase; Validated; Region: pyrG; PRK05380
440085013480	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
440085013481	Catalytic site [active]
440085013482	active site
440085013483	UTP binding site [chemical binding]; other site
440085013484	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
440085013485	active site
440085013486	putative oxyanion hole; other site
440085013487	catalytic triad [active]
440085013488	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
440085013489	catalytic triad [active]
440085013490	conserved cis-peptide bond; other site
440085013491	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
440085013492	triosephosphate isomerase; Provisional; Region: PRK14565
440085013493	substrate binding site [chemical binding]; other site
440085013494	dimer interface [polypeptide binding]; other site
440085013495	catalytic triad [active]
440085013496	periplasmic folding chaperone; Provisional; Region: PRK10788
440085013497	SurA N-terminal domain; Region: SurA_N_3; cl07813
440085013498	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
440085013499	anthranilate synthase component I; Provisional; Region: PRK13573
440085013500	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
440085013501	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
440085013502	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085013503	dimerization interface [polypeptide binding]; other site
440085013504	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085013505	dimer interface [polypeptide binding]; other site
440085013506	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085013507	putative CheW interface [polypeptide binding]; other site
440085013508	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
440085013509	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
440085013510	glutamine binding [chemical binding]; other site
440085013511	catalytic triad [active]
440085013512	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
440085013513	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
440085013514	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
440085013515	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
440085013516	active site
440085013517	ribulose/triose binding site [chemical binding]; other site
440085013518	phosphate binding site [ion binding]; other site
440085013519	substrate (anthranilate) binding pocket [chemical binding]; other site
440085013520	product (indole) binding pocket [chemical binding]; other site
440085013521	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
440085013522	trimer interface [polypeptide binding]; other site
440085013523	dimer interface [polypeptide binding]; other site
440085013524	putative active site [active]
440085013525	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
440085013526	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
440085013527	dimer interface [polypeptide binding]; other site
440085013528	putative functional site; other site
440085013529	putative MPT binding site; other site
440085013530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085013531	salt bridge; other site
440085013532	non-specific DNA binding site [nucleotide binding]; other site
440085013533	sequence-specific DNA binding site [nucleotide binding]; other site
440085013534	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
440085013535	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
440085013536	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
440085013537	active site
440085013538	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
440085013539	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
440085013540	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
440085013541	hypothetical protein; Validated; Region: PRK00124
440085013542	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
440085013543	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
440085013544	dimer interface [polypeptide binding]; other site
440085013545	active site
440085013546	citrylCoA binding site [chemical binding]; other site
440085013547	NADH binding [chemical binding]; other site
440085013548	cationic pore residues; other site
440085013549	oxalacetate/citrate binding site [chemical binding]; other site
440085013550	coenzyme A binding site [chemical binding]; other site
440085013551	catalytic triad [active]
440085013552	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
440085013553	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
440085013554	active site
440085013555	HIGH motif; other site
440085013556	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
440085013557	active site
440085013558	KMSKS motif; other site
440085013559	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
440085013560	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
440085013561	Competence protein; Region: Competence; pfam03772
440085013562	LexA repressor; Validated; Region: PRK00215
440085013563	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
440085013564	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
440085013565	Catalytic site [active]
440085013566	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
440085013567	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
440085013568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085013569	putative substrate translocation pore; other site
440085013570	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
440085013571	tartrate dehydrogenase; Region: TTC; TIGR02089
440085013572	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
440085013573	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
440085013574	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
440085013575	active site
440085013576	catalytic tetrad [active]
440085013577	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
440085013578	dimerization interface [polypeptide binding]; other site
440085013579	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085013580	dimer interface [polypeptide binding]; other site
440085013581	putative CheW interface [polypeptide binding]; other site
440085013582	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
440085013583	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085013584	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085013585	protein binding site [polypeptide binding]; other site
440085013586	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085013587	protein binding site [polypeptide binding]; other site
440085013588	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
440085013589	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
440085013590	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
440085013591	active site
440085013592	HIGH motif; other site
440085013593	nucleotide binding site [chemical binding]; other site
440085013594	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
440085013595	active site
440085013596	KMSKS motif; other site
440085013597	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
440085013598	tRNA binding surface [nucleotide binding]; other site
440085013599	anticodon binding site; other site
440085013600	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
440085013601	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
440085013602	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
440085013603	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
440085013604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085013605	S-adenosylmethionine binding site [chemical binding]; other site
440085013606	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
440085013607	chaperone protein DnaJ; Provisional; Region: PRK10767
440085013608	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
440085013609	putative substrate binding site [chemical binding]; other site
440085013610	putative ATP binding site [chemical binding]; other site
440085013611	PBP superfamily domain; Region: PBP_like_2; cl17296
440085013612	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
440085013613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085013614	dimer interface [polypeptide binding]; other site
440085013615	conserved gate region; other site
440085013616	putative PBP binding loops; other site
440085013617	ABC-ATPase subunit interface; other site
440085013618	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
440085013619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085013620	dimer interface [polypeptide binding]; other site
440085013621	conserved gate region; other site
440085013622	putative PBP binding loops; other site
440085013623	ABC-ATPase subunit interface; other site
440085013624	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
440085013625	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
440085013626	Walker A/P-loop; other site
440085013627	ATP binding site [chemical binding]; other site
440085013628	Q-loop/lid; other site
440085013629	ABC transporter signature motif; other site
440085013630	Walker B; other site
440085013631	D-loop; other site
440085013632	H-loop/switch region; other site
440085013633	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
440085013634	PhoU domain; Region: PhoU; pfam01895
440085013635	PhoU domain; Region: PhoU; pfam01895
440085013636	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
440085013637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085013638	active site
440085013639	phosphorylation site [posttranslational modification]
440085013640	intermolecular recognition site; other site
440085013641	dimerization interface [polypeptide binding]; other site
440085013642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085013643	DNA binding site [nucleotide binding]
440085013644	GcrA cell cycle regulator; Region: GcrA; cl11564
440085013645	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
440085013646	DNA polymerase IV; Provisional; Region: PRK02794
440085013647	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
440085013648	active site
440085013649	DNA binding site [nucleotide binding]
440085013650	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
440085013651	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
440085013652	cobyric acid synthase; Provisional; Region: PRK00784
440085013653	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085013654	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
440085013655	catalytic triad [active]
440085013656	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
440085013657	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
440085013658	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
440085013659	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085013660	catalytic residue [active]
440085013661	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
440085013662	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
440085013663	CsbD-like; Region: CsbD; pfam05532
440085013664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
440085013665	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
440085013666	NAD(P) binding site [chemical binding]; other site
440085013667	active site
440085013668	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
440085013669	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
440085013670	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
440085013671	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
440085013672	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
440085013673	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
440085013674	active site
440085013675	NTP binding site [chemical binding]; other site
440085013676	metal binding triad [ion binding]; metal-binding site
440085013677	Transglycosylase SLT domain; Region: SLT_2; pfam13406
440085013678	murein hydrolase B; Provisional; Region: PRK10760; cl17906
440085013679	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085013680	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
440085013681	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
440085013682	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
440085013683	RNA binding surface [nucleotide binding]; other site
440085013684	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
440085013685	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
440085013686	FMN binding site [chemical binding]; other site
440085013687	substrate binding site [chemical binding]; other site
440085013688	putative catalytic residue [active]
440085013689	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
440085013690	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
440085013691	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
440085013692	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085013693	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
440085013694	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
440085013695	Walker A/P-loop; other site
440085013696	ATP binding site [chemical binding]; other site
440085013697	Q-loop/lid; other site
440085013698	ABC transporter signature motif; other site
440085013699	Walker B; other site
440085013700	D-loop; other site
440085013701	H-loop/switch region; other site
440085013702	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
440085013703	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
440085013704	Methyltransferase domain; Region: Methyltransf_24; pfam13578
440085013705	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
440085013706	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
440085013707	active site
440085013708	HIGH motif; other site
440085013709	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
440085013710	KMSKS motif; other site
440085013711	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
440085013712	tRNA binding surface [nucleotide binding]; other site
440085013713	anticodon binding site; other site
440085013714	CreA protein; Region: CreA; pfam05981
440085013715	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
440085013716	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
440085013717	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085013718	ligand binding site [chemical binding]; other site
440085013719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085013720	putative substrate translocation pore; other site
440085013721	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085013722	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
440085013723	dimer interface [polypeptide binding]; other site
440085013724	Methyltransferase domain; Region: Methyltransf_31; pfam13847
440085013725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085013726	S-adenosylmethionine binding site [chemical binding]; other site
440085013727	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
440085013728	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
440085013729	active site
440085013730	HIGH motif; other site
440085013731	nucleotide binding site [chemical binding]; other site
440085013732	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
440085013733	active site
440085013734	KMSKS motif; other site
440085013735	multidrug resistance protein MdtN; Provisional; Region: PRK10476
440085013736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085013737	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085013738	Fusaric acid resistance protein family; Region: FUSC; pfam04632
440085013739	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
440085013740	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
440085013741	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
440085013742	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
440085013743	C-terminal domain interface [polypeptide binding]; other site
440085013744	GSH binding site (G-site) [chemical binding]; other site
440085013745	dimer interface [polypeptide binding]; other site
440085013746	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
440085013747	N-terminal domain interface [polypeptide binding]; other site
440085013748	putative dimer interface [polypeptide binding]; other site
440085013749	active site
440085013750	translocation protein TolB; Provisional; Region: tolB; PRK05137
440085013751	TolB amino-terminal domain; Region: TolB_N; pfam04052
440085013752	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
440085013753	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
440085013754	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
440085013755	TolA protein; Region: tolA_full; TIGR02794
440085013756	TolR protein; Region: tolR; TIGR02801
440085013757	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
440085013758	TolQ protein; Region: tolQ; TIGR02796
440085013759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085013760	dimer interface [polypeptide binding]; other site
440085013761	putative CheW interface [polypeptide binding]; other site
440085013762	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
440085013763	active site
440085013764	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
440085013765	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
440085013766	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085013767	putative active site [active]
440085013768	putative metal binding site [ion binding]; other site
440085013769	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
440085013770	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
440085013771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085013772	Walker A motif; other site
440085013773	ATP binding site [chemical binding]; other site
440085013774	Walker B motif; other site
440085013775	arginine finger; other site
440085013776	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
440085013777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
440085013778	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
440085013779	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
440085013780	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
440085013781	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
440085013782	dimerization interface [polypeptide binding]; other site
440085013783	DPS ferroxidase diiron center [ion binding]; other site
440085013784	ion pore; other site
440085013785	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
440085013786	CoA binding domain; Region: CoA_binding_2; pfam13380
440085013787	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
440085013788	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
440085013789	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
440085013790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085013791	Coenzyme A binding pocket [chemical binding]; other site
440085013792	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
440085013793	intersubunit interface [polypeptide binding]; other site
440085013794	active site
440085013795	Zn2+ binding site [ion binding]; other site
440085013796	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085013797	Restriction endonuclease; Region: Mrr_cat; pfam04471
440085013798	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
440085013799	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
440085013800	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
440085013801	Transglycosylase; Region: Transgly; pfam00912
440085013802	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
440085013803	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
440085013804	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085013805	cyclase homology domain; Region: CHD; cd07302
440085013806	nucleotidyl binding site; other site
440085013807	metal binding site [ion binding]; metal-binding site
440085013808	dimer interface [polypeptide binding]; other site
440085013809	MAPEG family; Region: MAPEG; cl09190
440085013810	AAA domain; Region: AAA_31; pfam13614
440085013811	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085013812	P-loop; other site
440085013813	Magnesium ion binding site [ion binding]; other site
440085013814	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085013815	Magnesium ion binding site [ion binding]; other site
440085013816	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
440085013817	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
440085013818	ring oligomerisation interface [polypeptide binding]; other site
440085013819	ATP/Mg binding site [chemical binding]; other site
440085013820	stacking interactions; other site
440085013821	hinge regions; other site
440085013822	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
440085013823	oligomerisation interface [polypeptide binding]; other site
440085013824	mobile loop; other site
440085013825	roof hairpin; other site
440085013826	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
440085013827	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
440085013828	Cl binding site [ion binding]; other site
440085013829	oligomer interface [polypeptide binding]; other site
440085013830	MarC family integral membrane protein; Region: MarC; cl00919
440085013831	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
440085013832	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
440085013833	FAD binding domain; Region: FAD_binding_4; pfam01565
440085013834	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
440085013835	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
440085013836	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
440085013837	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
440085013838	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
440085013839	Substrate binding site; other site
440085013840	Cupin domain; Region: Cupin_2; cl17218
440085013841	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
440085013842	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
440085013843	active site
440085013844	substrate binding site [chemical binding]; other site
440085013845	coenzyme B12 binding site [chemical binding]; other site
440085013846	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
440085013847	B12 binding site [chemical binding]; other site
440085013848	cobalt ligand [ion binding]; other site
440085013849	Protein of unknown function (DUF817); Region: DUF817; pfam05675
440085013850	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
440085013851	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
440085013852	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
440085013853	protein binding site [polypeptide binding]; other site
440085013854	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
440085013855	HSP70 interaction site [polypeptide binding]; other site
440085013856	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
440085013857	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
440085013858	Sporulation related domain; Region: SPOR; pfam05036
440085013859	Uncharacterized conserved protein [Function unknown]; Region: COG2127
440085013860	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
440085013861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085013862	Walker A motif; other site
440085013863	ATP binding site [chemical binding]; other site
440085013864	Walker B motif; other site
440085013865	arginine finger; other site
440085013866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085013867	Walker A motif; other site
440085013868	ATP binding site [chemical binding]; other site
440085013869	Walker B motif; other site
440085013870	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
440085013871	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
440085013872	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
440085013873	substrate-cofactor binding pocket; other site
440085013874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085013875	catalytic residue [active]
440085013876	putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055
440085013877	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
440085013878	diiron binding motif [ion binding]; other site
440085013879	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
440085013880	Bacterial PH domain; Region: DUF304; pfam03703
440085013881	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
440085013882	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
440085013883	subunit C interaction residues; other site
440085013884	subunit M interaction residues [polypeptide binding]; other site
440085013885	subunit L interaction residues [polypeptide binding]; other site
440085013886	putative proton transfer pathway, P1; other site
440085013887	putative proton transfer pathway, P2; other site
440085013888	PUCC protein; Region: PUCC; pfam03209
440085013889	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
440085013890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085013891	S-adenosylmethionine binding site [chemical binding]; other site
440085013892	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
440085013893	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
440085013894	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
440085013895	P-loop; other site
440085013896	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
440085013897	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
440085013898	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
440085013899	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
440085013900	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
440085013901	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
440085013902	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
440085013903	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
440085013904	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
440085013905	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
440085013906	B12 binding domain; Region: B12-binding; pfam02310
440085013907	B12 binding site [chemical binding]; other site
440085013908	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
440085013909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085013910	putative active site [active]
440085013911	heme pocket [chemical binding]; other site
440085013912	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085013913	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
440085013914	UbiA prenyltransferase family; Region: UbiA; pfam01040
440085013915	PUCC protein; Region: PUCC; pfam03209
440085013916	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
440085013917	TspO/MBR family; Region: TspO_MBR; pfam03073
440085013918	Cytochrome c; Region: Cytochrom_C; pfam00034
440085013919	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
440085013920	Cytochrome c; Region: Cytochrom_C; pfam00034
440085013921	Cytochrome c; Region: Cytochrom_C; pfam00034
440085013922	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
440085013923	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
440085013924	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
440085013925	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
440085013926	putative active site [active]
440085013927	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
440085013928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
440085013929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085013930	Walker A/P-loop; other site
440085013931	ATP binding site [chemical binding]; other site
440085013932	Q-loop/lid; other site
440085013933	ABC transporter signature motif; other site
440085013934	Walker B; other site
440085013935	D-loop; other site
440085013936	H-loop/switch region; other site
440085013937	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
440085013938	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
440085013939	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
440085013940	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
440085013941	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085013942	ligand binding site [chemical binding]; other site
440085013943	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
440085013944	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
440085013945	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
440085013946	Mechanosensitive ion channel; Region: MS_channel; pfam00924
440085013947	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
440085013948	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
440085013949	active site
440085013950	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
440085013951	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
440085013952	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
440085013953	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
440085013954	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
440085013955	active site
440085013956	substrate binding site [chemical binding]; other site
440085013957	metal binding site [ion binding]; metal-binding site
440085013958	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
440085013959	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
440085013960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085013961	Walker A motif; other site
440085013962	ATP binding site [chemical binding]; other site
440085013963	Walker B motif; other site
440085013964	arginine finger; other site
440085013965	Peptidase family M41; Region: Peptidase_M41; pfam01434
440085013966	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
440085013967	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
440085013968	Ligand Binding Site [chemical binding]; other site
440085013969	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
440085013970	Tetratricopeptide repeat; Region: TPR_6; pfam13174
440085013971	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
440085013972	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
440085013973	ligand binding site [chemical binding]; other site
440085013974	Response regulator receiver domain; Region: Response_reg; pfam00072
440085013975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085013976	active site
440085013977	phosphorylation site [posttranslational modification]
440085013978	intermolecular recognition site; other site
440085013979	dimerization interface [polypeptide binding]; other site
440085013980	GSCFA family; Region: GSCFA; pfam08885
440085013981	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
440085013982	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
440085013983	domain interfaces; other site
440085013984	active site
440085013985	integrase; Provisional; Region: int; PHA02601
440085013986	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085013987	active site
440085013988	DNA binding site [nucleotide binding]
440085013989	Int/Topo IB signature motif; other site
440085013990	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
440085013991	AAA domain; Region: AAA_30; pfam13604
440085013992	Family description; Region: UvrD_C_2; pfam13538
440085013993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085013994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085013995	integrase; Provisional; Region: int; PHA02601
440085013996	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085013997	active site
440085013998	DNA binding site [nucleotide binding]
440085013999	Int/Topo IB signature motif; other site
440085014000	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
440085014001	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
440085014002	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
440085014003	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
440085014004	putative active site [active]
440085014005	putative catalytic site [active]
440085014006	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
440085014007	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
440085014008	TM-ABC transporter signature motif; other site
440085014009	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
440085014010	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
440085014011	Walker A/P-loop; other site
440085014012	ATP binding site [chemical binding]; other site
440085014013	Q-loop/lid; other site
440085014014	ABC transporter signature motif; other site
440085014015	Walker B; other site
440085014016	D-loop; other site
440085014017	H-loop/switch region; other site
440085014018	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
440085014019	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
440085014020	Walker A/P-loop; other site
440085014021	ATP binding site [chemical binding]; other site
440085014022	Q-loop/lid; other site
440085014023	ABC transporter signature motif; other site
440085014024	Walker B; other site
440085014025	D-loop; other site
440085014026	H-loop/switch region; other site
440085014027	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
440085014028	TM-ABC transporter signature motif; other site
440085014029	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
440085014030	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
440085014031	putative ligand binding site [chemical binding]; other site
440085014032	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
440085014033	Transcriptional regulators [Transcription]; Region: GntR; COG1802
440085014034	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085014035	DNA-binding site [nucleotide binding]; DNA binding site
440085014036	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
440085014037	PAS fold; Region: PAS_3; pfam08447
440085014038	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
440085014039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085014040	non-specific DNA binding site [nucleotide binding]; other site
440085014041	salt bridge; other site
440085014042	sequence-specific DNA binding site [nucleotide binding]; other site
440085014043	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
440085014044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
440085014045	putative substrate translocation pore; other site
440085014046	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
440085014047	dimerization interface [polypeptide binding]; other site
440085014048	metal binding site [ion binding]; metal-binding site
440085014049	hypothetical protein; Validated; Region: PRK00029
440085014050	Uncharacterized conserved protein [Function unknown]; Region: COG0397
440085014051	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
440085014052	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
440085014053	PYR/PP interface [polypeptide binding]; other site
440085014054	dimer interface [polypeptide binding]; other site
440085014055	TPP binding site [chemical binding]; other site
440085014056	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
440085014057	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
440085014058	TPP-binding site [chemical binding]; other site
440085014059	dimer interface [polypeptide binding]; other site
440085014060	Methyltransferase domain; Region: Methyltransf_23; pfam13489
440085014061	Methyltransferase domain; Region: Methyltransf_12; pfam08242
440085014062	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
440085014063	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
440085014064	putative valine binding site [chemical binding]; other site
440085014065	dimer interface [polypeptide binding]; other site
440085014066	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
440085014067	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
440085014068	glutathionine S-transferase; Provisional; Region: PRK10542
440085014069	C-terminal domain interface [polypeptide binding]; other site
440085014070	GSH binding site (G-site) [chemical binding]; other site
440085014071	dimer interface [polypeptide binding]; other site
440085014072	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
440085014073	dimer interface [polypeptide binding]; other site
440085014074	substrate binding pocket (H-site) [chemical binding]; other site
440085014075	N-terminal domain interface [polypeptide binding]; other site
440085014076	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
440085014077	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
440085014078	active site
440085014079	dimer interface [polypeptide binding]; other site
440085014080	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
440085014081	Ligand Binding Site [chemical binding]; other site
440085014082	Molecular Tunnel; other site
440085014083	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
440085014084	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
440085014085	putative active site [active]
440085014086	putative dimer interface [polypeptide binding]; other site
440085014087	RNA polymerase sigma factor; Provisional; Region: PRK12546
440085014088	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085014089	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085014090	DNA binding residues [nucleotide binding]
440085014091	Response regulator receiver domain; Region: Response_reg; pfam00072
440085014092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014093	active site
440085014094	phosphorylation site [posttranslational modification]
440085014095	intermolecular recognition site; other site
440085014096	dimerization interface [polypeptide binding]; other site
440085014097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
440085014098	Histidine kinase; Region: HisKA_2; pfam07568
440085014099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085014100	ATP binding site [chemical binding]; other site
440085014101	Mg2+ binding site [ion binding]; other site
440085014102	G-X-G motif; other site
440085014103	Response regulator receiver domain; Region: Response_reg; pfam00072
440085014104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014105	active site
440085014106	phosphorylation site [posttranslational modification]
440085014107	intermolecular recognition site; other site
440085014108	dimerization interface [polypeptide binding]; other site
440085014109	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
440085014110	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085014111	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
440085014112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085014113	putative active site [active]
440085014114	PAS fold; Region: PAS_3; pfam08447
440085014115	heme pocket [chemical binding]; other site
440085014116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
440085014117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085014118	dimer interface [polypeptide binding]; other site
440085014119	phosphorylation site [posttranslational modification]
440085014120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085014121	ATP binding site [chemical binding]; other site
440085014122	Mg2+ binding site [ion binding]; other site
440085014123	G-X-G motif; other site
440085014124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085014125	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085014126	ligand binding site [chemical binding]; other site
440085014127	flexible hinge region; other site
440085014128	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
440085014129	putative switch regulator; other site
440085014130	non-specific DNA interactions [nucleotide binding]; other site
440085014131	DNA binding site [nucleotide binding]
440085014132	sequence specific DNA binding site [nucleotide binding]; other site
440085014133	putative cAMP binding site [chemical binding]; other site
440085014134	GAF domain; Region: GAF; pfam01590
440085014135	GAF domain; Region: GAF_2; pfam13185
440085014136	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085014137	PAS fold; Region: PAS_3; pfam08447
440085014138	putative active site [active]
440085014139	heme pocket [chemical binding]; other site
440085014140	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
440085014141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014142	active site
440085014143	phosphorylation site [posttranslational modification]
440085014144	intermolecular recognition site; other site
440085014145	dimerization interface [polypeptide binding]; other site
440085014146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085014147	DNA binding residues [nucleotide binding]
440085014148	dimerization interface [polypeptide binding]; other site
440085014149	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085014150	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
440085014151	catalytic residues [active]
440085014152	catalytic nucleophile [active]
440085014153	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
440085014154	DNA-binding interface [nucleotide binding]; DNA binding site
440085014155	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085014156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
440085014157	dimerization interface [polypeptide binding]; other site
440085014158	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
440085014159	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085014160	dimer interface [polypeptide binding]; other site
440085014161	putative CheW interface [polypeptide binding]; other site
440085014162	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
440085014163	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
440085014164	putative transposase OrfB; Reviewed; Region: PHA02517
440085014165	HTH-like domain; Region: HTH_21; pfam13276
440085014166	Integrase core domain; Region: rve; pfam00665
440085014167	Integrase core domain; Region: rve_3; pfam13683
440085014168	Transposase; Region: HTH_Tnp_1; pfam01527
440085014169	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
440085014170	PAS domain; Region: PAS_9; pfam13426
440085014171	putative active site [active]
440085014172	heme pocket [chemical binding]; other site
440085014173	PAS fold; Region: PAS_3; pfam08447
440085014174	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
440085014175	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
440085014176	GAF domain; Region: GAF; pfam01590
440085014177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085014178	dimer interface [polypeptide binding]; other site
440085014179	phosphorylation site [posttranslational modification]
440085014180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085014181	ATP binding site [chemical binding]; other site
440085014182	Mg2+ binding site [ion binding]; other site
440085014183	G-X-G motif; other site
440085014184	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
440085014185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014186	active site
440085014187	phosphorylation site [posttranslational modification]
440085014188	intermolecular recognition site; other site
440085014189	dimerization interface [polypeptide binding]; other site
440085014190	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
440085014191	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
440085014192	acyl-activating enzyme (AAE) consensus motif; other site
440085014193	AMP binding site [chemical binding]; other site
440085014194	active site
440085014195	CoA binding site [chemical binding]; other site
440085014196	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085014197	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085014198	active site
440085014199	DNA binding site [nucleotide binding]
440085014200	Int/Topo IB signature motif; other site
440085014201	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
440085014202	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085014203	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
440085014204	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
440085014205	sulfite oxidase; Provisional; Region: PLN00177
440085014206	Moco binding site; other site
440085014207	metal coordination site [ion binding]; other site
440085014208	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
440085014209	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
440085014210	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085014211	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085014212	DNA binding residues [nucleotide binding]
440085014213	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
440085014214	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
440085014215	DNA-binding site [nucleotide binding]; DNA binding site
440085014216	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085014217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085014218	homodimer interface [polypeptide binding]; other site
440085014219	catalytic residue [active]
440085014220	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
440085014221	Predicted amidohydrolase [General function prediction only]; Region: COG0388
440085014222	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
440085014223	putative active site [active]
440085014224	catalytic triad [active]
440085014225	putative dimer interface [polypeptide binding]; other site
440085014226	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
440085014227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
440085014228	Coenzyme A binding pocket [chemical binding]; other site
440085014229	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
440085014230	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
440085014231	dimerization interface [polypeptide binding]; other site
440085014232	putative ATP binding site [chemical binding]; other site
440085014233	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
440085014234	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
440085014235	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
440085014236	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
440085014237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
440085014238	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
440085014239	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085014240	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
440085014241	catalytic residues [active]
440085014242	Recombinase; Region: Recombinase; pfam07508
440085014243	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085014244	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
440085014245	catalytic residues [active]
440085014246	catalytic nucleophile [active]
440085014247	Recombinase; Region: Recombinase; pfam07508
440085014248	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
440085014249	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014250	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
440085014251	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
440085014252	putative ion selectivity filter; other site
440085014253	putative pore gating glutamate residue; other site
440085014254	putative H+/Cl- coupling transport residue; other site
440085014255	TIR domain; Region: TIR_2; pfam13676
440085014256	TIR domain; Region: TIR_2; cl17458
440085014257	Uncharacterized conserved protein [Function unknown]; Region: COG1262
440085014258	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
440085014259	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
440085014260	Part of AAA domain; Region: AAA_19; pfam13245
440085014261	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
440085014262	DEAD-like helicases superfamily; Region: DEXDc; smart00487
440085014263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
440085014264	ATP binding site [chemical binding]; other site
440085014265	putative Mg++ binding site [ion binding]; other site
440085014266	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
440085014267	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
440085014268	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
440085014269	tellurite resistance protein terB; Region: terB; cd07176
440085014270	putative metal binding site [ion binding]; other site
440085014271	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
440085014272	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
440085014273	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
440085014274	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
440085014275	active site
440085014276	catalytic site [active]
440085014277	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
440085014278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085014279	S-adenosylmethionine binding site [chemical binding]; other site
440085014280	TIR domain; Region: TIR_2; pfam13676
440085014281	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
440085014282	TIR domain; Region: TIR_2; pfam13676
440085014283	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
440085014284	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
440085014285	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085014286	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085014287	active site
440085014288	DNA binding site [nucleotide binding]
440085014289	Int/Topo IB signature motif; other site
440085014290	Transposase, Mutator family; Region: Transposase_mut; pfam00872
440085014291	MULE transposase domain; Region: MULE; pfam10551
440085014292	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085014293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085014294	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085014295	Transposase, Mutator family; Region: Transposase_mut; pfam00872
440085014296	MULE transposase domain; Region: MULE; pfam10551
440085014297	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
440085014298	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
440085014299	Trp docking motif [polypeptide binding]; other site
440085014300	dimer interface [polypeptide binding]; other site
440085014301	active site
440085014302	small subunit binding site [polypeptide binding]; other site
440085014303	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085014304	dimerization interface [polypeptide binding]; other site
440085014305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
440085014306	Histidine kinase; Region: HisKA_3; pfam07730
440085014307	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
440085014308	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
440085014309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014310	active site
440085014311	phosphorylation site [posttranslational modification]
440085014312	intermolecular recognition site; other site
440085014313	dimerization interface [polypeptide binding]; other site
440085014314	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
440085014315	DNA binding residues [nucleotide binding]
440085014316	dimerization interface [polypeptide binding]; other site
440085014317	Integrase core domain; Region: rve; pfam00665
440085014318	Integrase core domain; Region: rve_3; pfam13683
440085014319	HTH-like domain; Region: HTH_21; pfam13276
440085014320	Integrase core domain; Region: rve; pfam00665
440085014321	DDE domain; Region: DDE_Tnp_IS240; pfam13610
440085014322	Integrase core domain; Region: rve_3; pfam13683
440085014323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014324	Transposase; Region: HTH_Tnp_1; pfam01527
440085014325	Helix-turn-helix domain; Region: HTH_28; pfam13518
440085014326	putative transposase OrfB; Reviewed; Region: PHA02517
440085014327	Homeodomain-like domain; Region: HTH_32; pfam13565
440085014328	Integrase core domain; Region: rve; pfam00665
440085014329	Integrase core domain; Region: rve_3; pfam13683
440085014330	Transposase; Region: HTH_Tnp_1; pfam01527
440085014331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014332	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085014333	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085014334	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085014335	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
440085014336	HPP family; Region: HPP; pfam04982
440085014337	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
440085014338	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
440085014339	homotrimer interaction site [polypeptide binding]; other site
440085014340	zinc binding site [ion binding]; other site
440085014341	CDP-binding sites; other site
440085014342	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
440085014343	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
440085014344	active site
440085014345	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
440085014346	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
440085014347	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
440085014348	NAD(P) binding site [chemical binding]; other site
440085014349	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
440085014350	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
440085014351	catalytic residue [active]
440085014352	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
440085014353	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
440085014354	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
440085014355	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
440085014356	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
440085014357	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085014358	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
440085014359	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085014360	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
440085014361	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085014362	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
440085014363	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
440085014364	Helix-turn-helix domain; Region: HTH_37; pfam13744
440085014365	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085014366	Ligand Binding Site [chemical binding]; other site
440085014367	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
440085014368	Ligand Binding Site [chemical binding]; other site
440085014369	Helix-turn-helix domain; Region: HTH_28; pfam13518
440085014370	Winged helix-turn helix; Region: HTH_29; pfam13551
440085014371	Homeodomain-like domain; Region: HTH_32; pfam13565
440085014372	Winged helix-turn helix; Region: HTH_33; pfam13592
440085014373	DDE superfamily endonuclease; Region: DDE_3; pfam13358
440085014374	AAA domain; Region: AAA_23; pfam13476
440085014375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085014376	Walker A/P-loop; other site
440085014377	ATP binding site [chemical binding]; other site
440085014378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014379	Transposase; Region: HTH_Tnp_1; pfam01527
440085014380	HTH-like domain; Region: HTH_21; pfam13276
440085014381	Integrase core domain; Region: rve; pfam00665
440085014382	DDE domain; Region: DDE_Tnp_IS240; pfam13610
440085014383	Integrase core domain; Region: rve_3; pfam13683
440085014384	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
440085014385	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
440085014386	active site
440085014387	catalytic triad [active]
440085014388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014389	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085014390	Walker A motif; other site
440085014391	ATP binding site [chemical binding]; other site
440085014392	Walker B motif; other site
440085014393	arginine finger; other site
440085014394	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
440085014395	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
440085014396	Active site cavity [active]
440085014397	catalytic acid [active]
440085014398	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085014399	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085014400	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
440085014401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
440085014402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
440085014403	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085014404	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085014405	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085014406	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
440085014407	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085014408	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085014409	dimerization interface [polypeptide binding]; other site
440085014410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
440085014411	dimer interface [polypeptide binding]; other site
440085014412	phosphorylation site [posttranslational modification]
440085014413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085014414	ATP binding site [chemical binding]; other site
440085014415	Mg2+ binding site [ion binding]; other site
440085014416	G-X-G motif; other site
440085014417	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
440085014418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014419	active site
440085014420	phosphorylation site [posttranslational modification]
440085014421	intermolecular recognition site; other site
440085014422	dimerization interface [polypeptide binding]; other site
440085014423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014424	Walker A motif; other site
440085014425	ATP binding site [chemical binding]; other site
440085014426	Walker B motif; other site
440085014427	arginine finger; other site
440085014428	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085014429	Major Facilitator Superfamily; Region: MFS_1; pfam07690
440085014430	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
440085014431	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085014432	N-terminal plug; other site
440085014433	ligand-binding site [chemical binding]; other site
440085014434	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014435	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014436	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014437	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
440085014438	Helix-turn-helix domain; Region: HTH_28; pfam13518
440085014439	putative transposase OrfB; Reviewed; Region: PHA02517
440085014440	Homeodomain-like domain; Region: HTH_32; pfam13565
440085014441	Integrase core domain; Region: rve; pfam00665
440085014442	Integrase core domain; Region: rve_3; pfam13683
440085014443	Transposase; Region: HTH_Tnp_1; pfam01527
440085014444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014445	Avidin family; Region: Avidin; pfam01382
440085014446	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
440085014447	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
440085014448	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
440085014449	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
440085014450	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
440085014451	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
440085014452	dimer interface [polypeptide binding]; other site
440085014453	putative functional site; other site
440085014454	putative MPT binding site; other site
440085014455	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
440085014456	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
440085014457	putative NAD(P) binding site [chemical binding]; other site
440085014458	putative substrate binding site [chemical binding]; other site
440085014459	catalytic Zn binding site [ion binding]; other site
440085014460	structural Zn binding site [ion binding]; other site
440085014461	dimer interface [polypeptide binding]; other site
440085014462	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
440085014463	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
440085014464	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
440085014465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
440085014466	dimer interface [polypeptide binding]; other site
440085014467	conserved gate region; other site
440085014468	putative PBP binding loops; other site
440085014469	ABC-ATPase subunit interface; other site
440085014470	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
440085014471	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
440085014472	Walker A/P-loop; other site
440085014473	ATP binding site [chemical binding]; other site
440085014474	Q-loop/lid; other site
440085014475	ABC transporter signature motif; other site
440085014476	Walker B; other site
440085014477	D-loop; other site
440085014478	H-loop/switch region; other site
440085014479	TOBE domain; Region: TOBE; cl01440
440085014480	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
440085014481	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085014482	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
440085014483	catalytic residues [active]
440085014484	catalytic nucleophile [active]
440085014485	Presynaptic Site I dimer interface [polypeptide binding]; other site
440085014486	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
440085014487	Synaptic Flat tetramer interface [polypeptide binding]; other site
440085014488	Synaptic Site I dimer interface [polypeptide binding]; other site
440085014489	DNA binding site [nucleotide binding]
440085014490	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
440085014491	DNA-binding interface [nucleotide binding]; DNA binding site
440085014492	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085014493	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
440085014494	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
440085014495	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
440085014496	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
440085014497	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
440085014498	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
440085014499	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
440085014500	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
440085014501	GAF domain; Region: GAF; pfam01590
440085014502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014503	Walker A motif; other site
440085014504	ATP binding site [chemical binding]; other site
440085014505	Walker B motif; other site
440085014506	arginine finger; other site
440085014507	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
440085014508	putative transposase OrfB; Reviewed; Region: PHA02517
440085014509	HTH-like domain; Region: HTH_21; pfam13276
440085014510	Integrase core domain; Region: rve; pfam00665
440085014511	Integrase core domain; Region: rve_3; pfam13683
440085014512	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
440085014513	DNA-binding interface [nucleotide binding]; DNA binding site
440085014514	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
440085014515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
440085014516	metal binding site [ion binding]; metal-binding site
440085014517	active site
440085014518	I-site; other site
440085014519	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085014520	Protein of unknown function (DUF736); Region: DUF736; pfam05284
440085014521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085014522	putative DNA binding site [nucleotide binding]; other site
440085014523	putative Zn2+ binding site [ion binding]; other site
440085014524	WYL domain; Region: WYL; pfam13280
440085014525	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
440085014526	homotrimer interaction site [polypeptide binding]; other site
440085014527	putative active site [active]
440085014528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014529	Transposase; Region: HTH_Tnp_1; pfam01527
440085014530	HTH-like domain; Region: HTH_21; pfam13276
440085014531	Integrase core domain; Region: rve; pfam00665
440085014532	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085014533	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085014534	Phosphotransferase enzyme family; Region: APH; pfam01636
440085014535	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
440085014536	active site
440085014537	substrate binding site [chemical binding]; other site
440085014538	ATP binding site [chemical binding]; other site
440085014539	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
440085014540	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
440085014541	homodimer interface [polypeptide binding]; other site
440085014542	active site
440085014543	TDP-binding site; other site
440085014544	acceptor substrate-binding pocket; other site
440085014545	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
440085014546	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
440085014547	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
440085014548	putative active site [active]
440085014549	Protein of unknown function (DUF736); Region: DUF736; pfam05284
440085014550	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
440085014551	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
440085014552	HAMP domain; Region: HAMP; pfam00672
440085014553	dimerization interface [polypeptide binding]; other site
440085014554	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085014555	dimer interface [polypeptide binding]; other site
440085014556	putative CheW interface [polypeptide binding]; other site
440085014557	Transposase, Mutator family; Region: Transposase_mut; pfam00872
440085014558	MULE transposase domain; Region: MULE; pfam10551
440085014559	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
440085014560	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
440085014561	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
440085014562	ParB-like nuclease domain; Region: ParB; smart00470
440085014563	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
440085014564	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085014565	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
440085014566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
440085014567	S-adenosylmethionine binding site [chemical binding]; other site
440085014568	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
440085014569	Helicase_C-like; Region: Helicase_C_4; pfam13871
440085014570	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
440085014571	active site
440085014572	metal binding site [ion binding]; metal-binding site
440085014573	interdomain interaction site; other site
440085014574	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
440085014575	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
440085014576	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085014577	Walker A motif; other site
440085014578	ATP binding site [chemical binding]; other site
440085014579	Walker B motif; other site
440085014580	Conjugal transfer protein TraD; Region: TraD; pfam06412
440085014581	TraC-like protein; Region: TraC; cl06725
440085014582	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
440085014583	MobA/MobL family; Region: MobA_MobL; pfam03389
440085014584	AAA domain; Region: AAA_30; pfam13604
440085014585	Family description; Region: UvrD_C_2; pfam13538
440085014586	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
440085014587	Fic/DOC family; Region: Fic; pfam02661
440085014588	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014589	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014590	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014591	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
440085014592	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
440085014593	NAD binding site [chemical binding]; other site
440085014594	catalytic Zn binding site [ion binding]; other site
440085014595	structural Zn binding site [ion binding]; other site
440085014596	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
440085014597	catalytic core [active]
440085014598	ParA-like protein; Provisional; Region: PHA02518
440085014599	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085014600	P-loop; other site
440085014601	Magnesium ion binding site [ion binding]; other site
440085014602	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014603	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014604	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014605	AAA-like domain; Region: AAA_10; pfam12846
440085014606	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
440085014607	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
440085014608	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
440085014609	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
440085014610	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
440085014611	Walker A motif; other site
440085014612	ATP binding site [chemical binding]; other site
440085014613	Walker B motif; other site
440085014614	Peptidase M15; Region: Peptidase_M15_3; cl01194
440085014615	Peptidase family M23; Region: Peptidase_M23; pfam01551
440085014616	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
440085014617	Homeodomain-like domain; Region: HTH_23; cl17451
440085014618	Winged helix-turn helix; Region: HTH_29; pfam13551
440085014619	Helix-turn-helix domain; Region: HTH_38; pfam13936
440085014620	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
440085014621	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
440085014622	DNA binding residues [nucleotide binding]
440085014623	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085014624	P-loop; other site
440085014625	Magnesium ion binding site [ion binding]; other site
440085014626	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085014627	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
440085014628	ParB-like nuclease domain; Region: ParBc; pfam02195
440085014629	replication initiation protein RepC; Provisional; Region: PRK13824
440085014630	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
440085014631	putative DNA binding site [nucleotide binding]; other site
440085014632	putative Zn2+ binding site [ion binding]; other site
440085014633	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
440085014634	Helix-turn-helix domain; Region: HTH_28; pfam13518
440085014635	Winged helix-turn helix; Region: HTH_29; pfam13551
440085014636	Homeodomain-like domain; Region: HTH_32; pfam13565
440085014637	Winged helix-turn helix; Region: HTH_33; pfam13592
440085014638	DDE superfamily endonuclease; Region: DDE_3; pfam13358
440085014639	Integrase core domain; Region: rve; pfam00665
440085014640	transposase; Validated; Region: PRK08181
440085014641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014642	Walker A motif; other site
440085014643	ATP binding site [chemical binding]; other site
440085014644	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
440085014645	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014646	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014647	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014648	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
440085014649	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
440085014650	catalytic residues [active]
440085014651	catalytic nucleophile [active]
440085014652	Presynaptic Site I dimer interface [polypeptide binding]; other site
440085014653	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
440085014654	Synaptic Flat tetramer interface [polypeptide binding]; other site
440085014655	Synaptic Site I dimer interface [polypeptide binding]; other site
440085014656	DNA binding site [nucleotide binding]
440085014657	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
440085014658	DNA-binding interface [nucleotide binding]; DNA binding site
440085014659	Protein of unknown function (DUF497); Region: DUF497; pfam04365
440085014660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
440085014661	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014662	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014663	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
440085014664	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014665	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
440085014666	PLD-like domain; Region: PLDc_2; pfam13091
440085014667	homodimer interface [polypeptide binding]; other site
440085014668	putative active site [active]
440085014669	catalytic site [active]
440085014670	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
440085014671	Methyltransferase domain; Region: Methyltransf_26; pfam13659
440085014672	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
440085014673	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014674	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
440085014675	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
440085014676	Major royal jelly protein; Region: MRJP; pfam03022
440085014677	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085014678	Transposase; Region: DEDD_Tnp_IS110; pfam01548
440085014679	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
440085014680	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
440085014681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
440085014682	Transposase; Region: HTH_Tnp_1; pfam01527
440085014683	HTH-like domain; Region: HTH_21; pfam13276
440085014684	Integrase core domain; Region: rve; pfam00665
440085014685	DDE domain; Region: DDE_Tnp_IS240; pfam13610
440085014686	Integrase core domain; Region: rve_3; pfam13683
440085014687	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
440085014688	putative active site [active]
440085014689	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
440085014690	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
440085014691	DNA binding site [nucleotide binding]
440085014692	dimer interface [polypeptide binding]; other site
440085014693	active site
440085014694	Int/Topo IB signature motif; other site
440085014695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085014696	non-specific DNA binding site [nucleotide binding]; other site
440085014697	salt bridge; other site
440085014698	sequence-specific DNA binding site [nucleotide binding]; other site
440085014699	Domain of unknown function (DUF955); Region: DUF955; pfam06114
440085014700	cyclase homology domain; Region: CHD; cd07302
440085014701	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
440085014702	cyclase homology domain; Region: CHD; cd07302
440085014703	nucleotidyl binding site; other site
440085014704	metal binding site [ion binding]; metal-binding site
440085014705	dimer interface [polypeptide binding]; other site
440085014706	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
440085014707	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
440085014708	ligand binding site [chemical binding]; other site
440085014709	flexible hinge region; other site
440085014710	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
440085014711	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
440085014712	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
440085014713	active site
440085014714	catalytic triad [active]
440085014715	catalytic residues [active]
440085014716	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
440085014717	CENP-B N-terminal DNA-binding domain; Region: CENP-B_N; pfam04218
440085014718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
440085014719	Integrase core domain; Region: rve; pfam00665
440085014720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
440085014721	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
440085014722	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
440085014723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014724	Walker A motif; other site
440085014725	ATP binding site [chemical binding]; other site
440085014726	Walker B motif; other site
440085014727	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
440085014728	putative active site [active]
440085014729	catalytic site [active]
440085014730	SIR2-like domain; Region: SIR2_2; pfam13289
440085014731	Transposase domain (DUF772); Region: DUF772; pfam05598
440085014732	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
440085014733	SIR2-like domain; Region: SIR2_2; pfam13289
440085014734	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
440085014735	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
440085014736	active site
440085014737	catalytic residues [active]
440085014738	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
440085014739	Zn binding site [ion binding]; other site
440085014740	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
440085014741	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
440085014742	putative active site [active]
440085014743	putative metal binding site [ion binding]; other site
440085014744	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
440085014745	active site
440085014746	catalytic site [active]
440085014747	substrate binding site [chemical binding]; other site
440085014748	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
440085014749	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
440085014750	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
440085014751	Walker A motif; other site
440085014752	ATP binding site [chemical binding]; other site
440085014753	Walker B motif; other site
440085014754	arginine finger; other site
440085014755	Peptidase family M41; Region: Peptidase_M41; pfam01434
440085014756	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085014757	TIR domain; Region: TIR_2; cl17458
440085014758	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085014759	PQQ-like domain; Region: PQQ_2; pfam13360
440085014760	structural tetrad; other site
440085014761	TIR domain; Region: TIR_2; pfam13676
440085014762	FOG: WD40 repeat [General function prediction only]; Region: COG2319
440085014763	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085014764	structural tetrad; other site
440085014765	FOG: WD40 repeat [General function prediction only]; Region: COG2319
440085014766	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
440085014767	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
440085014768	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
440085014769	N-terminal plug; other site
440085014770	ligand-binding site [chemical binding]; other site
440085014771	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
440085014772	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
440085014773	intersubunit interface [polypeptide binding]; other site
440085014774	FecCD transport family; Region: FecCD; pfam01032
440085014775	putative PBP binding regions; other site
440085014776	ABC-ATPase subunit  interface; other site
440085014777	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
440085014778	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
440085014779	Walker A/P-loop; other site
440085014780	ATP binding site [chemical binding]; other site
440085014781	Q-loop/lid; other site
440085014782	ABC transporter signature motif; other site
440085014783	Walker B; other site
440085014784	D-loop; other site
440085014785	H-loop/switch region; other site
440085014786	AAA domain; Region: AAA_33; pfam13671
440085014787	AAA domain; Region: AAA_17; pfam13207
440085014788	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
440085014789	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
440085014790	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
440085014791	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
440085014792	MOFRL family; Region: MOFRL; pfam05161
440085014793	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
440085014794	active site
440085014795	SAM binding site [chemical binding]; other site
440085014796	homodimer interface [polypeptide binding]; other site
440085014797	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
440085014798	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
440085014799	active site
440085014800	putative homodimer interface [polypeptide binding]; other site
440085014801	SAM binding site [chemical binding]; other site
440085014802	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
440085014803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
440085014804	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
440085014805	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
440085014806	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
440085014807	active site
440085014808	SAM binding site [chemical binding]; other site
440085014809	homodimer interface [polypeptide binding]; other site
440085014810	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
440085014811	active site
440085014812	SAM binding site [chemical binding]; other site
440085014813	homodimer interface [polypeptide binding]; other site
440085014814	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
440085014815	Precorrin-8X methylmutase; Region: CbiC; pfam02570
440085014816	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085014817	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
440085014818	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
440085014819	imidazolonepropionase; Validated; Region: PRK09356
440085014820	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
440085014821	active site
440085014822	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
440085014823	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
440085014824	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
440085014825	B12 binding site [chemical binding]; other site
440085014826	cobalt ligand [ion binding]; other site
440085014827	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
440085014828	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
440085014829	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
440085014830	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
440085014831	putative active site [active]
440085014832	putative substrate binding site [chemical binding]; other site
440085014833	putative cosubstrate binding site; other site
440085014834	catalytic site [active]
440085014835	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
440085014836	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
440085014837	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
440085014838	homodimer interface [polypeptide binding]; other site
440085014839	NADP binding site [chemical binding]; other site
440085014840	substrate binding site [chemical binding]; other site
440085014841	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
440085014842	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
440085014843	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
440085014844	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
440085014845	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
440085014846	putative dimer interface [polypeptide binding]; other site
440085014847	active site pocket [active]
440085014848	putative cataytic base [active]
440085014849	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085014850	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
440085014851	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
440085014852	active site
440085014853	metal binding site [ion binding]; metal-binding site
440085014854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
440085014855	non-specific DNA binding site [nucleotide binding]; other site
440085014856	salt bridge; other site
440085014857	sequence-specific DNA binding site [nucleotide binding]; other site
440085014858	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
440085014859	dimerization interface [polypeptide binding]; other site
440085014860	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
440085014861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
440085014862	ATP binding site [chemical binding]; other site
440085014863	Mg2+ binding site [ion binding]; other site
440085014864	G-X-G motif; other site
440085014865	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
440085014866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
440085014867	active site
440085014868	phosphorylation site [posttranslational modification]
440085014869	intermolecular recognition site; other site
440085014870	dimerization interface [polypeptide binding]; other site
440085014871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
440085014872	DNA binding site [nucleotide binding]
440085014873	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
440085014874	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
440085014875	HlyD family secretion protein; Region: HlyD_3; pfam13437
440085014876	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
440085014877	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
440085014878	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
440085014879	FAD binding pocket [chemical binding]; other site
440085014880	FAD binding motif [chemical binding]; other site
440085014881	phosphate binding motif [ion binding]; other site
440085014882	beta-alpha-beta structure motif; other site
440085014883	NAD(p) ribose binding residues [chemical binding]; other site
440085014884	NAD binding pocket [chemical binding]; other site
440085014885	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
440085014886	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
440085014887	catalytic loop [active]
440085014888	iron binding site [ion binding]; other site
440085014889	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
440085014890	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
440085014891	gating phenylalanine in ion channel; other site
440085014892	HPP family; Region: HPP; pfam04982
440085014893	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
440085014894	heme-binding site [chemical binding]; other site
440085014895	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
440085014896	dimer interface [polypeptide binding]; other site
440085014897	putative CheW interface [polypeptide binding]; other site
440085014898	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
440085014899	homotrimer interface [polypeptide binding]; other site
440085014900	Walker A motif; other site
440085014901	GTP binding site [chemical binding]; other site
440085014902	Walker B motif; other site
440085014903	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
440085014904	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
440085014905	cobyric acid synthase; Provisional; Region: PRK00784
440085014906	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
440085014907	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
440085014908	catalytic triad [active]
440085014909	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
440085014910	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
440085014911	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
440085014912	DNA binding residues [nucleotide binding]
440085014913	dimer interface [polypeptide binding]; other site
440085014914	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
440085014915	FAD binding site [chemical binding]; other site
440085014916	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
440085014917	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
440085014918	CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309
440085014919	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
440085014920	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
440085014921	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
440085014922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
440085014923	homodimer interface [polypeptide binding]; other site
440085014924	catalytic residue [active]
440085014925	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
440085014926	active site
440085014927	SAM binding site [chemical binding]; other site
440085014928	homodimer interface [polypeptide binding]; other site
440085014929	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
440085014930	putative FMN binding site [chemical binding]; other site
440085014931	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
440085014932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
440085014933	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
440085014934	DNA binding residues [nucleotide binding]
440085014935	Domain of unknown function (DUF305); Region: DUF305; cl17794
440085014936	Helix-turn-helix domain; Region: HTH_36; pfam13730
440085014937	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
440085014938	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
440085014939	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
440085014940	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
440085014941	Flagellar protein FlbT; Region: FlbT; cl11455
440085014942	unknown domain/lipoate-protein ligase A fusion protein; Provisional; Region: PRK14061
440085014943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
440085014944	non-specific DNA binding site [nucleotide binding]; other site
440085014945	salt bridge; other site
440085014946	sequence-specific DNA binding site [nucleotide binding]; other site
440085014947	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
440085014948	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
440085014949	P-loop; other site
440085014950	Magnesium ion binding site [ion binding]; other site
440085014951	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
440085014952	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
440085014953	active site
440085014954	DNA binding site [nucleotide binding]
440085014955	Int/Topo IB signature motif; other site
440085014956	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
440085014957	Flagellar protein FlbT; Region: FlbT; cl11455
440085014958	Family of unknown function (DUF1028); Region: DUF1028; pfam06267